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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CYP2F1 Gene

protein-coding   GIFtS: 66
GCID: GC19P041620

Cytochrome P450, Family 2, Subfamily F, Polypeptide 1

(Previous names: cytochrome P450, subfamily IIF, polypeptide 1)
(Previous symbol: CYP2F)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Cytochrome P450, Family 2, Subfamily F, Polypeptide 11 2     C2F12
CYP2F1 2     Cytochrome P450 2F12
Cytochrome P450, Subfamily IIF, Polypeptide 11 2     Flavoprotein-Linked Monooxygenase2
CYPIIF12 3     Microsomal Monooxygenase2
EC 1.14.14.13 8     Xenobiotic Monooxygenase2

External Ids:    HGNC: 26321   Entrez Gene: 15722   Ensembl: ENSG000001974467   OMIM: 1240705   UniProtKB: P249033   

Export aliases for CYP2F1 gene to outside databases

Previous GC identifers: GC19P042259 GC19P042012 GC19P046109 GC19P046125 GC19P046129 GC19P046312 GC19P038052


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CYP2F1 Gene:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are
monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids
and other lipids. This protein localizes to the endoplasmic reticulum and is known to dehydrogenate
3-methylindole, an endogenous toxin derived from the fermentation of tryptophan, as well as xenobiotic substrates
such as naphthalene and ethoxycoumarin. This gene is part of a large cluster of cytochrome P450 genes from the
CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. (provided by RefSeq, Jul 2008)

GeneCards Summary for CYP2F1 Gene: 
CYP2F1 (cytochrome P450, family 2, subfamily F, polypeptide 1) is a protein-coding gene. Diseases associated with CYP2F1 include vaccinia, and cytochrome p450, and among its related super-pathways are Cytochrome P450 - arranged by substrate type and Phase II conjugation. GO annotations related to this gene include electron carrier activity and heme binding. An important paralog of this gene is CYP2W1.

UniProtKB/Swiss-Prot: CP2F1_HUMAN, P24903
Function: May be involved in the metabolism of various pneumotoxicants including naphthalene. Is able to
dealkylate ethoxycoumarin, propoxycoumarin, and pentoxyresorufin but possesses no activity toward ethoxyresorufin
and only trace dearylation activity toward benzyloxyresorufin. Bioactivates 3-methylindole (3MI) by
dehydrogenation to the putative electrophile 3-methylene-indolenine

Gene Wiki entry for CYP2F1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011109.16  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CYP2F1 gene promoter:
         Sp1   HNF-4alpha1   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCYP2F1 promoter sequence
   Search SABiosciences Chromatin IP Primers for CYP2F1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CYP2F1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.2   Ensembl cytogenetic band:  19q13.2   HGNC cytogenetic band: 19q13.1-q13.2

CYP2F1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CYP2F1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P041620:  view genomic region     (about GC identifiers)

Start:
41,620,337 bp from pter      End:
41,634,281 bp from pter
Size:
13,945 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CP2F1_HUMAN, P24903 (See protein sequence)
Recommended Name: Cytochrome P450 2F1  
Size: 491 amino acids; 55501 Da
Cofactor: Heme group (By similarity)
Subcellular location: Endoplasmic reticulum membrane; Peripheral membrane protein (Probable). Microsome membrane;
Peripheral membrane protein
Secondary accessions: A7KAU6 A7KAU7 A7KAU8 A7KAU9 A7KAV0 Q8WWJ2

Explore the universe of human proteins at neXtProt for CYP2F1: NX_P24903

Explore proteomics data for CYP2F1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P24903

  • 4/13 DME Specific Peptides for CYP2F1 (P24903) (see all 13)
     GKLPPGP  FGMGKRS  EEFSGRG  VKEALVD 

    CYP2F1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CYP2F1 Protein Expression
    REFSEQ proteins: NP_000765.2  
    ENSEMBL proteins: 
     ENSP00000333534   ENSP00000471416   ENSP00000470136   ENSP00000443424  
    Reactome Protein details: P24903
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    Cloud-Clone Corp. Proteins for CYP2F1 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0043231intracellular membrane-bounded organelle IDA10383923

    CYP2F1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CYP: Cytochrome P450s

    IUPHAR Guide to PHARMACOLOGY protein family classification: CYP2F1 
    CYP2 family

    4 InterPro protein domains:
     IPR001128 Cyt_P450
     IPR017972 Cyt_P450_CS
     IPR002401 Cyt_P450_E_grp-I
     IPR020469 Cyt_P450_CYP2_fam

    Graphical View of Domain Structure for InterPro Entry P24903

    ProtoNet protein and cluster: P24903

    2 Blocks protein domains:
    IPB002401 E-class P450 group I signature
    IPB008068 CYP2B P450 family signature


    UniProtKB/Swiss-Prot: CP2F1_HUMAN, P24903
    Similarity: Belongs to the cytochrome P450 family


    CYP2F1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CP2F1_HUMAN, P24903
    Function: May be involved in the metabolism of various pneumotoxicants including naphthalene. Is able to
    dealkylate ethoxycoumarin, propoxycoumarin, and pentoxyresorufin but possesses no activity toward ethoxyresorufin
    and only trace dearylation activity toward benzyloxyresorufin. Bioactivates 3-methylindole (3MI) by
    dehydrogenation to the putative electrophile 3-methylene-indolenine
    Catalytic activity: RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O
    Biophysicochemical properties: Kinetic parameters: KM=0.018 mM for 3-methylindole; Vmax=51.2 pmol/min/mg enzyme
    toward ethoxy-coumarin; Vmax=24.3 pmol/min/mg enzyme toward propoxy-coumarin; Vmax=22 pmol/min/mg enzyme toward
    pentoxy-resorufin; Vmax=2.29 pmol/min/mg enzyme toward benzyloxy-resorufin;

         Genatlas biochemistry entry for CYP2F1:
    cytochrome P450,subfamily IIF,member 1,tightly linked to a full size LTR of human endogenous retroviruses
    HERV-K,component of a CYP2@ within 240kb,?order

         Enzyme Number (IUBMB): EC 1.14.14.11 2

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004497monooxygenase activity TAS1974816
    GO:0005506iron ion binding IEA--
    GO:0009055electron carrier activity IEA--
    GO:0016705oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen ----
    GO:0016712oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IDA10383923
         
    CYP2F1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CYP2F1:
     Decreased nuclei size in G2M 

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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CYP2F1 About   (see all 10)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Cytochrome P450 - arranged by substrate type
    Cytochrome P450 - arranged by substrate type0.75
    Phase 1 - Functionalization of compounds0.74
    cytochrome P4500.75
    2Biological oxidations
    Biological oxidations0.55
    metapathway biotransformation0.41
    3Xenobiotics
    Xenobiotics0.55
    CYP2E1 reactions0.55
    4Drug metabolism - cytochrome P450
    Metabolism of xenobiotics by cytochrome P4500.77
    5Fatty acids
    Fatty acids0.50

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 EMD Millipore Pathways for CYP2F1
        Dichloroethylene metabolism
    2-Naphthylamine and 2-Nitronaphtalene metabolism
    Naphthalene metabolism


    3 GeneGo (Thomson Reuters) Pathways for CYP2F1
        Naphthalene metabolism
    2-Naphthylamine and 2-Nitronaphtalene metabolism
    Dichloroethylene metabolism

    3 BioSystems Pathways for CYP2F1
        cytochrome P450
    metapathway biotransformation
    Tryptophan metabolism

    5/7        Reactome Pathways for CYP2F1 (see all 7)
        Cytochrome P450 - arranged by substrate type
    Fatty acids
    Xenobiotics
    Metabolism
    Biological oxidations


    1         Kegg Pathway  (Kegg details for CYP2F1):
        Metabolism of xenobiotics by cytochrome P450


    CYP2F1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CYP2F1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/53 Interacting proteins for CYP2F1 (ENSP000003335344) via UniProtKB, MINT, STRING, and/or I2D (see all 53)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ADH1AENSP000002096684STRING: ENSP00000209668
    ADH1BENSP000003066064STRING: ENSP00000306606
    ALDH1A3ENSP000003322564STRING: ENSP00000332256
    EPHX1ENSP000002721674STRING: ENSP00000272167
    GSTA1ENSP000003356204STRING: ENSP00000335620
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006805xenobiotic metabolic process TAS--
    GO:0009636response to toxic substance IEA--
    GO:0018931naphthalene metabolic process IDA10383923
    GO:0018979trichloroethylene metabolic process IEA--
    GO:0044281small molecule metabolic process TAS--

    CYP2F1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CYP2F1 (CP2F1)

    10/50 HMDB Compounds for CYP2F1 (see all 50)    About this table
    CompoundSynonyms CAS #PubMed Ids
    10-HETE10-hydroxyeicosa-all-cis-5,8,11,14-tetraenoate (see all 2)167697-52-1--
    11,12,15-THETA11,12,15-Trihydroxyicosatrienoic acid (see all 5)----
    11,12-Epoxyeicosatrienoic acid10-(3-(2-octenyl)oxiranyl)-5,8-Decadienoic acid (see all 15)81276-02-0--
    11,14,15-THETA(5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoic acid (see all 8)----
    11H-14,15-EETA14,15-Ep-11-HETrE (see all 11)219535-29-2--
    11beta-Hydroxytestosterone11beta,17beta-dihydroxyandrost-4-en-3-one 1816-85-9--
    12,13-EpOMEVernolic acid (see all 12)----
    13-HETE13-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoate (see all 2)151910-72-4--
    14,15-Epoxy-5,8,11-eicosatrienoic acid(5Z,8Z,11Z)-14,15-Epoxyicosa-5.8.11-trienoic acid (see all 11)81276-03-1--
    15(S)-HPETE(5Z,8Z,11Z,13E)-(15S)-15-Hydroperoxyicosa-5,8,11,13-tetraenoate (see all 8)70981-96-3--

    Search CenterWatch for drugs/clinical trials and news about CYP2F1 / CP2F1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CYP2F1 gene: 
    NM_000774.3  

    Unigene Cluster for CYP2F1:

    Cytochrome P450, family 2, subfamily F, polypeptide 1
    Hs.558318  [show with all ESTs]
    Unigene Representative Sequence: AK298082
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000526093(uc021uuv.1) ENST00000531409(uc010xvv.1) ENST00000331105(uc002opu.1 uc002opv.1)
    ENST00000532164 ENST00000534009 ENST00000439903
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    Additional mRNA sequence: 

    AK296884.1 AK298082.1 AK316498.1 BC109056.1 BC109057.1 J02906.1 

    4 DOTS entries:

    DT.102624  DT.121503462  DT.99996904  DT.95094345 

    7 AceView cDNA sequences:

    CB306453 NM_000774 J02906 BM968957 BE829867 BI063387 CD688412 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for CYP2F1    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
    SP1:                                                                        
    SP2:                                                                        


    ECgene alternative splicing isoforms for CYP2F1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CYP2F1 expression in normal human tissues (normalized intensities)      CYP2F1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CYP2F1 Expression
    About this image


    CYP2F1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/7 selected tissues (see all 7) fully expand
     
     Nose (Sensory Organs)    fully expand to see all 2 entries
             sensory organ/nose/nasal cavity   
     
     Lung (Respiratory System)    fully expand to see all 2 entries
             Stem Bronchi
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Inner Cell Mass (Early Embryonic Tissues)
             Line H9 (WA09)
     
     Liver (Hepatobiliary System)
             Periportal Hepatocytes Liver Lobule

    See CYP2F1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CYP2F1

    SOURCE GeneReport for Unigene cluster: Hs.558318

    UniProtKB/Swiss-Prot: CP2F1_HUMAN, P24903
    Tissue specificity: Expressed in lung. Rarely detected in liver and placenta

        SABiosciences Expression via Pathway-Focused PCR Arrays including CYP2F1: 
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CYP2F1 gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cyp2f21 , 5 cytochrome P450, family 2, subfamily f, polypeptide more1, 5 82.62(n)1
    81.87(a)1
      7 (15.82 cM)5
    131071  NM_007817.21  NP_031843.21 
     271199095 
    lizard
    (Anolis carolinensis)
    Reptilia CYP2F16
    --
    (see all 11)
    Uncharacterized protein
    (see all 11)
    60(a)
    52(a)
    (see all 11)
    1 ↔ 1
    possible ortholog
    (see all 11)
    LGf(2898626-2917434)
    LGf(2919159-2936531)
    zebrafish
    (Danio rerio)
    Actinopterygii cyp2y36
    CU928854.16
    Uncharacterized protein
    47(a)
    46(a)
    1 ↔ many
    1 ↔ many
    15(65144-71354)
    15(54297-58832)


    ENSEMBL Gene Tree for CYP2F1 (if available)
    TreeFam Gene Tree for CYP2F1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CYP2F1 gene
    CYP2W12  CYP2C82  CYP2A62  CYP2A72  CYP2B62  CYP2C192  CYP2R12  CYP2J22  
    CYP2U12  CYP2S12  CYP2E12  CYP2C92  CYP2D62  CYP2C182  CYP2A132  
    18/29 SIMAP similar genes for CYP2F1 using alignment to 4 protein entries:     CP2F1_HUMAN (see all proteins) (see all similar genes):
    CYP2A13    CYP2A6    CYP2A6V2    CYP2C19    CYP 2C    CYP2C18
    CYP2E1    CYP2B7    CYP2C9    CYP2A7    CYP2B    CYP2C8
    CYP2G1P    CYP2B6    CYP2S1    CYP2J2    DKFZp686I24235    CYP2W1

    CYP2F1 for paralogs           About GeneDecksing


    4 Pseudogenes.org Pseudogenes for CYP2F1
    PGOHUM00000234318 PGOHUM00000259331 PGOHUM00000258061 PGOHUM00000234700


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: CP2F1_HUMAN, P24903
    Polymorphism: Eight non disease-associated alleles are known: CYP2F1*1, CYP2F1*2A, CYP2F1*2B, CYP2F1*3, CYP2F1*4,
    CYP2F1*5A, CYP2F1*5B and CYP2F1*6. The sequence shown corresponds to allele CYP2F1*1


    10/531 SNPs in CYP2F1 are shown (see all 531)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0588664
    ----see VAR_0588662 Q H mis40--------
    rs674941891,2
    C--38050992(+) TCTTC-/T/TT  
            
    TTTTT
    1 -- us2k11NA 2
    rs112983631,2
    C--41619091(+) TTTTT-/TTTTTT 1 -- us2k1 trp31Minor allele frequency- T:0.00NA 2
    rs1134669871,2
    C,F--41620831(+) CACCAC/TGCCTG 1 -- int11Minor allele frequency- T:0.50CSA 2
    rs105992451,2
    C--41621443(+) GTGAT-/A/GATA
            
    GATAG
    1 -- int10--------
    rs38332211,2
    C--41622107(+) ATAAGC/-CACAG 2 /T /H fra11Minor allele frequency- -:0.00NA 2
    rs108537471,2
    C,A,H--41625628(+) tctctA/Ctatat 1 -- int1 trp31Minor allele frequency- C:0.00NA 2
    rs590363701,2
    C--41630151(+) CTCTTC/TCCCCC 1 -- int10--------
    rs17091191,2
    C,F,A--41634229(-) AAGCCC/TAGAAA 1 -- ut31 ese32Minor allele frequency- T:0.50NA WA 4
    rs717938721,2
    C--41634255(+) ACATT-/TGTAAT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for CYP2F1 (41620337 - 41634281 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CYP2F1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv2492CNV Insertion18451855
    esv28334CNV Loss19812545


    Human Gene Mutation Database (HGMD): CYP2F1

    Locus Specific Mutation Databases (LSDB): CYP2F1
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CYP2F1
    DNA2.0 Custom Variant and Variant Library Synthesis for CYP2F1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 124070    OMIM disorders: --

    4 diseases for CYP2F1:    About MalaCards
    vaccinia    cytochrome p450    colorectal cancer    ovarian cancer


    CYP2F1 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for CYP2F1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    metastasis 0 2 15897573 (1)

    Genetic Association Database (GAD): CYP2F1
    Human Genome Epidemiology (HuGE) Navigator: CYP2F1 (6 documents)

    Export disorders for CYP2F1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CYP2F1 gene, integrated from 9 sources (see all 34):
    (articles sorted by number of sources associating them with CYP2F1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular analysis of the CYP2F1 gene: identification of a frequent non-functional allelic variant. (PubMed id 17327131)1, 2, 4 Tournel G....Lo-Guidice J.-M. (2007)
    2. CYP2F1 genetic polymorphism: identification of interethnic variations. (PubMed id 17943660)1, 4, 9 Tournel G....Lo-Guidice J.M. (2007)
    3. Identification and cross-species comparisons of CYP2F subfamily genes in mammals. (PubMed id 11827709)1, 2, 9 Chen N.... Hoffman S.M.G. (2002)
    4. The human CYP2F gene subfamily: identification of a cDNA encoding a new cytochrome P450, cDNA-directed expression, and chromosome mapping. (PubMed id 1974816)1, 2, 9 Nhamburo P.T....Gonzalez F.J. (1990)
    5. [The CYP1B1 and CYP2F1 genes polymorphisms frequency in three ethnic groups of Bashkortostan and chronic obstructive pulmonary disea se patients] (PubMed id 20198857)1, 4 Korytina G.F....Viktorova T.V. (2010)
    6. Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PubMed id 19343046)1, 4 Saito A....Kamatani N. (2009)
    7. [Study on genetic polymorphisms of CYP2F1 gene in Guangdong population of China] (PubMed id 16883522)1, 4 Jiang J.H....Zeng Y.X. (2006)
    8. Specific dehydrogenation of 3-methylindole and epoxidation of naphthalene by recombinant human CYP2F1 expressed in lymphoblastoid cells. (PubMed id 10383923)1, 2 Lanza D.L.... Yost G.S. (1999)
    9. Expression of xenobiotic-metabolizing cytochrome P450 forms in human full-term placenta. (PubMed id 8619884)1, 2 Hakkola J....Raunio H. (1996)
    10. Characterization of the human lung CYP2F1 gene and identification of a novel lung-specific binding motif. (PubMed id 12598524)1, 9 Carr B.A....Yost G.S. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1572 HGNC: 2632 AceView: CYP2F1 Ensembl:ENSG00000197446 euGenes: HUgn1572
    ECgene: CYP2F1 Kegg: 1572 H-InvDB: CYP2F1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CYP2F1 Pharmacogenomics, SNPs, Pathways
    Cytochrome P450 Allele Nomenclature Committeehttp://www.cypalleles.ki.se/cyp2f1.htm

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CYP2F1 gene:
    Search GeneIP for patents involving CYP2F1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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