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Aliases for CYP2F1 Gene

Aliases for CYP2F1 Gene

  • Cytochrome P450, Family 2, Subfamily F, Polypeptide 1 2 3
  • Cytochrome P450, Subfamily IIF, Polypeptide 1 2 3
  • EC 1.14.14.1 4 63
  • CYPIIF1 3 4
  • Flavoprotein-Linked Monooxygenase 3
  • Microsomal Monooxygenase 3
  • Xenobiotic Monooxygenase 3
  • Cytochrome P450 2F1 3
  • CYP2F 3
  • C2F1 3

External Ids for CYP2F1 Gene

Previous HGNC Symbols for CYP2F1 Gene

  • CYP2F

Previous GeneCards Identifiers for CYP2F1 Gene

  • GC19P042259
  • GC19P042012
  • GC19P046109
  • GC19P046125
  • GC19P046129
  • GC19P046312
  • GC19P041620
  • GC19P038052

Summaries for CYP2F1 Gene

Entrez Gene Summary for CYP2F1 Gene

  • This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to dehydrogenate 3-methylindole, an endogenous toxin derived from the fermentation of tryptophan, as well as xenobiotic substrates such as naphthalene and ethoxycoumarin. This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. [provided by RefSeq, Jul 2008]

GeneCards Summary for CYP2F1 Gene

CYP2F1 (Cytochrome P450, Family 2, Subfamily F, Polypeptide 1) is a Protein Coding gene. Among its related pathways are Metabolism and Biological oxidations. GO annotations related to this gene include electron carrier activity and heme binding. An important paralog of this gene is CYP2C19.

UniProtKB/Swiss-Prot for CYP2F1 Gene

  • May be involved in the metabolism of various pneumotoxicants including naphthalene. Is able to dealkylate ethoxycoumarin, propoxycoumarin, and pentoxyresorufin but possesses no activity toward ethoxyresorufin and only trace dearylation activity toward benzyloxyresorufin. Bioactivates 3-methylindole (3MI) by dehydrogenation to the putative electrophile 3-methylene-indolenine.

Gene Wiki entry for CYP2F1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYP2F1 Gene

Genomics for CYP2F1 Gene

Regulatory Elements for CYP2F1 Gene

Genomic Location for CYP2F1 Gene

Start:
41,114,432 bp from pter
End:
41,128,376 bp from pter
Size:
13,945 bases
Orientation:
Plus strand

Genomic View for CYP2F1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CYP2F1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYP2F1 Gene

Proteins for CYP2F1 Gene

  • Protein details for CYP2F1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P24903-CP2F1_HUMAN
    Recommended name:
    Cytochrome P450 2F1
    Protein Accession:
    P24903
    Secondary Accessions:
    • A7KAU6
    • A7KAU7
    • A7KAU8
    • A7KAU9
    • A7KAV0
    • Q32MN5
    • Q8WWJ2

    Protein attributes for CYP2F1 Gene

    Size:
    491 amino acids
    Molecular mass:
    55501 Da
    Cofactor:
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CYP2F1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CYP2F1 Gene

Proteomics data for CYP2F1 Gene at MOPED

Post-translational modifications for CYP2F1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CYP2F1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for CYP2F1 Gene

Gene Families for CYP2F1 Gene

HGNC:
  • CYP :Cytochrome P450s
IUPHAR :

Suggested Antigen Peptide Sequences for CYP2F1 Gene

Graphical View of Domain Structure for InterPro Entry

P24903

UniProtKB/Swiss-Prot:

CP2F1_HUMAN :
  • P24903
Family:
  • Belongs to the cytochrome P450 family.
genes like me logo Genes that share domains with CYP2F1: view

Function for CYP2F1 Gene

Molecular function for CYP2F1 Gene

GENATLAS Biochemistry: cytochrome P450,subfamily IIF,member 1,tightly linked to a full size LTR of human endogenous retroviruses HERV-K,component of a CYP2@ within 240kb,?order
UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=0.018 mM for 3-methylindole {ECO:0000269 PubMed:10383923, ECO:0000269 PubMed:1974816}; Vmax=51.2 pmol/min/mg enzyme toward ethoxy-coumarin {ECO:0000269 PubMed:10383923, ECO:0000269 PubMed:1974816}; Vmax=24.3 pmol/min/mg enzyme toward propoxy-coumarin {ECO:0000269 PubMed:10383923, ECO:0000269 PubMed:1974816}; Vmax=22 pmol/min/mg enzyme toward pentoxy-resorufin {ECO:0000269 PubMed:10383923, ECO:0000269 PubMed:1974816}; Vmax=2.29 pmol/min/mg enzyme toward benzyloxy-resorufin {ECO:0000269 PubMed:10383923, ECO:0000269 PubMed:1974816};
UniProtKB/Swiss-Prot CatalyticActivity: RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O.
UniProtKB/Swiss-Prot Function: May be involved in the metabolism of various pneumotoxicants including naphthalene. Is able to dealkylate ethoxycoumarin, propoxycoumarin, and pentoxyresorufin but possesses no activity toward ethoxyresorufin and only trace dearylation activity toward benzyloxyresorufin. Bioactivates 3-methylindole (3MI) by dehydrogenation to the putative electrophile 3-methylene-indolenine.

Enzyme Numbers (IUBMB) for CYP2F1 Gene

Gene Ontology (GO) - Molecular Function for CYP2F1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004497 monooxygenase activity TAS 1974816
GO:0005506 iron ion binding IEA --
GO:0008392 arachidonic acid epoxygenase activity IBA --
GO:0008395 steroid hydroxylase activity IBA --
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen --
genes like me logo Genes that share ontologies with CYP2F1: view

Phenotypes for CYP2F1 Gene

MGI mutant phenotypes for CYP2F1:
inferred from 1 alleles
GenomeRNAi human phenotypes for CYP2F1:
genes like me logo Genes that share phenotypes with CYP2F1: view

Animal Models for CYP2F1 Gene

MGI Knock Outs for CYP2F1:

miRNA for CYP2F1 Gene

miRTarBase miRNAs that target CYP2F1

No data available for Transcription Factor Targeting and HOMER Transcription for CYP2F1 Gene

Localization for CYP2F1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYP2F1 Gene

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CYP2F1 Gene COMPARTMENTS Subcellular localization image for CYP2F1 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 2
nucleus 1

Gene Ontology (GO) - Cellular Components for CYP2F1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0043231 intracellular membrane-bounded organelle IDA 10383923
genes like me logo Genes that share ontologies with CYP2F1: view

Pathways for CYP2F1 Gene

genes like me logo Genes that share pathways with CYP2F1: view

Interacting Proteins for CYP2F1 Gene

Gene Ontology (GO) - Biological Process for CYP2F1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006805 xenobiotic metabolic process TAS --
GO:0009636 response to toxic substance IEA --
GO:0018931 naphthalene metabolic process IDA 10383923
GO:0018979 trichloroethylene metabolic process IEA --
GO:0019373 epoxygenase P450 pathway IBA --
genes like me logo Genes that share ontologies with CYP2F1: view

Compounds for CYP2F1 Gene

(50) HMDB Compounds for CYP2F1 Gene

Compound Synonyms Cas Number PubMed IDs
10-HETE
  • 10-hydroxyeicosa-all-cis-5,8,11,14-tetraenoate
167697-52-1
11,12,15-THETA
  • 11,12,15-Trihydroxyicosatrienoic acid
Not Available
11,12-Epoxyeicosatrienoic acid
  • 10-(3-(2-octenyl)oxiranyl)-5,8-Decadienoic acid
81276-02-0
11,14,15-THETA
  • (5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoic acid
Not Available
11beta-Hydroxytestosterone
  • 11beta,17beta-dihydroxyandrost-4-en-3-one
1816-85-9
genes like me logo Genes that share compounds with CYP2F1: view

Transcripts for CYP2F1 Gene

mRNA/cDNA for CYP2F1 Gene

(7) REFSEQ mRNAs :
(7) Selected AceView cDNA sequences:
(6) Additional mRNA sequences :
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CYP2F1 Gene

Cytochrome P450, family 2, subfamily F, polypeptide 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CYP2F1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
SP1:
SP2:

Relevant External Links for CYP2F1 Gene

GeneLoc Exon Structure for
CYP2F1
ECgene alternative splicing isoforms for
CYP2F1

Expression for CYP2F1 Gene

mRNA expression in normal human tissues for CYP2F1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CYP2F1 Gene

This gene is overexpressed in Minor Salivary Gland (14.3), Testis (12.5), Vagina (9.1), Lung (7.5), and Esophagus - Mucosa (6.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CYP2F1 Gene

SOURCE GeneReport for Unigene cluster for CYP2F1 Gene Hs.558318

mRNA Expression by UniProt/SwissProt for CYP2F1 Gene

P24903-CP2F1_HUMAN
Tissue specificity: Expressed in lung. Rarely detected in liver and placenta.
genes like me logo Genes that share expressions with CYP2F1: view

Orthologs for CYP2F1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CYP2F1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC738883 35
  • 94.77 (n)
  • 93.39 (a)
cow
(Bos Taurus)
Mammalia CYP2F1 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CYP2F1 36
  • 89 (a)
OneToOne
LOC612477 35
  • 88.46 (n)
  • 88.8 (a)
mouse
(Mus musculus)
Mammalia Cyp2f2 35
  • 82.62 (n)
  • 81.87 (a)
Cyp2f2 16
Cyp2f2 36
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CYP2F1 36
  • 72 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cyp2f4 35
  • 82.76 (n)
  • 83.06 (a)
lizard
(Anolis carolinensis)
Reptilia CYP2F1 36
  • 60 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Cyp304a1 37
  • 30 (a)
Cyp307a1 37
  • 27 (a)
Cyp18a1 37
  • 34 (a)
worm
(Caenorhabditis elegans)
Secernentea F14H3.10 37
  • 29 (a)
B0213.12 37
  • 30 (a)
T10H4.11 37
  • 32 (a)
Y5H2B.6 37
  • 30 (a)
F42A9.5 37
  • 32 (a)
Y49C4A.9 37
  • 32 (a)
B0213.16 37
  • 29 (a)
B0213.10 37
  • 29 (a)
K09A11.4 37
  • 34 (a)
C03G6.14 37
  • 26 (a)
B0213.14 37
  • 29 (a)
C25E10.2 37
  • 30 (a)
K09D9.2 37
  • 29 (a)
C12D5.7 37
  • 32 (a)
K07C6.5 37
  • 27 (a)
C49G7.8 37
  • 28 (a)
B0213.15 37
  • 28 (a)
C03G6.15 37
  • 29 (a)
B0213.11 37
  • 33 (a)
T09H2.1 37
  • 30 (a)
T10H4.10 37
  • 30 (a)
Species with no ortholog for CYP2F1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for CYP2F1 Gene

ENSEMBL:
Gene Tree for CYP2F1 (if available)
TreeFam:
Gene Tree for CYP2F1 (if available)

Paralogs for CYP2F1 Gene

Pseudogenes.org Pseudogenes for CYP2F1 Gene

genes like me logo Genes that share paralogs with CYP2F1: view

Variants for CYP2F1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for CYP2F1 Gene

P24903-CP2F1_HUMAN
Eight non disease-associated alleles are known: CYP2F1*1, CYP2F1*2A, CYP2F1*2B, CYP2F1*3, CYP2F1*4, CYP2F1*5A, CYP2F1*5B and CYP2F1*6. The sequence shown corresponds to allele CYP2F1*1

Sequence variations from dbSNP and Humsavar for CYP2F1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs3920 -- 41,128,246(+) TCTGT(A/G)CCCCG utr-variant-3-prime, nc-transcript-variant
rs184247 -- 41,115,066(+) tgccc(A/G)gccTC intron-variant, upstream-variant-2KB
rs305967 -- 41,115,784(+) aagaa(A/G)gaaaa intron-variant, upstream-variant-2KB
rs305968 -- 41,116,284(+) CCTCC(A/G)GGACC synonymous-codon, reference, nc-transcript-variant
rs305969 -- 41,117,378(+) ccacc(C/T)acctc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CYP2F1 Gene

Variant ID Type Subtype PubMed ID
nsv2492 CNV Insertion 18451855
esv28334 CNV Loss 19812545

Relevant External Links for CYP2F1 Gene

HapMap Linkage Disequilibrium report
CYP2F1
Human Gene Mutation Database (HGMD)
CYP2F1
Locus Specific Mutation Databases (LSDB)
CYP2F1
The Human Cytochrome P450 Allele Nomenclature Database
CYP2F1

Disorders for CYP2F1 Gene

(1) Novoseek inferred disease relationships for CYP2F1 Gene

Disease -log(P) Hits PubMed IDs
metastasis 0 1

Relevant External Links for CYP2F1

Genetic Association Database (GAD)
CYP2F1
Human Genome Epidemiology (HuGE) Navigator
CYP2F1
genes like me logo Genes that share disorders with CYP2F1: view

No data available for UniProtKB/Swiss-Prot for CYP2F1 Gene

Publications for CYP2F1 Gene

  1. Identification and cross-species comparisons of CYP2F subfamily genes in mammals. (PMID: 11827709) Chen N. … Hoffman S.M.G. (Mutat. Res. 2002) 3 4 23
  2. The human CYP2F gene subfamily: identification of a cDNA encoding a new cytochrome P450, cDNA-directed expression, and chromosome mapping. (PMID: 1974816) Nhamburo P.T. … Gonzalez F.J. (Biochemistry 1990) 3 4 23
  3. CYP2F1 genetic polymorphism: identification of interethnic variations. (PMID: 17943660) Tournel G. … Lo-Guidice J.-. (Xenobiotica 2007) 3 23 48
  4. Molecular analysis of the CYP2F1 gene: identification of a frequent non-functional allelic variant. (PMID: 17327131) Tournel G. … Lo-Guidice J.-M. (Mutat. Res. 2007) 3 4 48
  5. Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PMID: 19343046) Saito A. … Kamatani N. (J. Hum. Genet. 2009) 3 48

Products for CYP2F1 Gene

Sources for CYP2F1 Gene

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