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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CYP2F1 Gene

protein-coding GIFtS: 65
GCID: GC19P041620

cytochrome P450, family 2, subfamily F, polypeptide 1

(Previous names: cytochrome P450, subfamily IIF, polypeptide 1 )
(Previous symbol: CYP2F)

Explore 4 diseases affiliated with
CYP2F1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Cytochrome P450, Family 2, Subfamily F, Polypeptide 1¹ ²		C2F1²
CYP2F¹ ²		Cytochrome P450 2F1²
Cytochrome P450, Subfamily IIF, Polypeptide 1¹ ²		Flavoprotein-Linked Monooxygenase²
CYPIIF1² ³		Microsomal Monooxygenase²
EC 1.14.14.1³ ⁸		Xenobiotic Monooxygenase²

External Ids:	HGNC: 2632¹	Entrez Gene: 1572²	Ensembl: ENSG00000197446⁷	OMIM: 124070⁵	UniProtKB: P24903³

Export aliases for CYP2F1 gene to outside databases

Previous GC identifers: GC19P042259 GC19P042012 GC19P046109 GC19P046125 GC19P046129 GC19P046312 GC19P038052

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CYP2F1:

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are

monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and

other lipids. This protein localizes to the endoplasmic reticulum and is known to dehydrogenate 3-methylindole, an

endogenous toxin derived from the fermentation of tryptophan, as well as xenobiotic substrates such as naphthalene and

ethoxycoumarin. This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F

subfamilies on chromosome 19q. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CP2F1_HUMAN, P24903

Function: May be involved in the metabolism of various pneumotoxicants including naphthalene. Is able to dealkylate

ethoxycoumarin, propoxycoumarin, and pentoxyresorufin but possesses no activity toward ethoxyresorufin and only trace

dearylation activity toward benzyloxyresorufin. Bioactivates 3-methylindole (3MI) by dehydrogenation to the putative

electrophile 3-methylene-indolenine

Gene Wiki entry for CYP2F1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000019.9 NC_018930.1 NT_011109.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CYP2F1 gene promoter:
Sp1 HNF-4alpha1 C/EBPalpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CYP2F1 promoter sequence

Search SABiosciences Chromatin IP Primers for CYP2F1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CYP2F1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.2 Ensembl cytogenetic band: 19q13.2 HGNC cytogenetic band: 19q13.1-q13.2

CYP2F1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CYP2F1 gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19P041620: view genomic region (about GC identifiers)

Start:	41,620,337 bp from pter	End:	41,634,281 bp from pter
Size:	13,945 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CP2F1_HUMAN, P24903 (See protein sequence)

Recommended Name: Cytochrome P450 2F1

Size: 491 amino acids; 55501 Da

Cofactor: Heme group (By similarity)

Subcellular location: Endoplasmic reticulum membrane; Peripheral membrane protein (Probable). Microsome membrane;

Peripheral membrane protein

Secondary accessions: A7KAU6 A7KAU7 A7KAU8 A7KAU9 A7KAV0 Q8WWJ2

Explore the universe of human proteins at neXtProt for CYP2F1: NX_P24903

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P24903

4/13 DME Specific Peptides for CYP2F1 (P24903) (see all 13)

GKLPPGP

FGMGKRS

EEFSGRG

VKEALVD

CYP2F1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_000765.2

ENSEMBL proteins:

ENSP00000437320 ENSP00000333534 ENSP00000443424

Reactome Protein details: P24903
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	Uscn Proteins for CYP2F1

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005789	endoplasmic reticulum membrane	TAS	--
GO:0005792	microsome	--	--
GO:0043231	intracellular membrane-bounded organelle	IDA	10383923

CYP2F1 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for CYP2F1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CYP2F1 for domains About GeneDecksing

4 InterPro domains/families:

IPR001128 Cyt_P450

IPR017972 Cyt_P450_CS

IPR002401 Cyt_P450_E_grp-I

IPR020469 Cyt_P450_CYP2_fam

Graphical View of Domain Structure for InterPro Entry P24903

ProtoNet protein and cluster: P24903

2 Blocks protein families:

IPB002401 E-class P450 group I signature

IPB008068 CYP2B P450 family signature

UniProtKB/Swiss-Prot: CP2F1_HUMAN, P24903

Similarity: Belongs to the cytochrome P450 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: CP2F1_HUMAN, P24903

Function: May be involved in the metabolism of various pneumotoxicants including naphthalene. Is able to dealkylate

ethoxycoumarin, propoxycoumarin, and pentoxyresorufin but possesses no activity toward ethoxyresorufin and only trace

dearylation activity toward benzyloxyresorufin. Bioactivates 3-methylindole (3MI) by dehydrogenation to the putative

electrophile 3-methylene-indolenine

Catalytic activity: RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O

Biophysicochemical properties: Kinetic parameters: KM=0.018 mM for 3-methylindole; Vmax=51.2 pmol/min/mg enzyme toward

ethoxy-coumarin; Vmax=24.3 pmol/min/mg enzyme toward propoxy-coumarin; Vmax=22 pmol/min/mg enzyme toward

pentoxy-resorufin; Vmax=2.29 pmol/min/mg enzyme toward benzyloxy-resorufin;

Genatlas biochemistry entry for CYP2F1:

cytochrome P450,subfamily IIF,member 1,tightly linked to a full size LTR of human endogenous retroviruses

HERV-K,component of a CYP2@ within 240kb,?order

Enzyme Number (IUBMB): EC 1.14.14.1¹ ²

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYP2F1

Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004497	monooxygenase activity	TAS	1974816
GO:0005506	iron ion binding	IEA	--
GO:0009055	electron carrier activity	IEA	--
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	--	--
GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	IDA	10383923

CYP2F1 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for CYP2F1:

Decreased nuclei size in G2M

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/9 super-pathways (see all 9) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Cytochrome P450 - arranged by substrate type

	Cytochrome P450 - arranged by substrate type	1.00			cytochrome P450	0.73
	Phase 1 - Functionalization of compounds	0.74

2-Naphthylamine and 2-Nitronaphtalene metabolism

2-Naphthylamine and 2-Nitronaphtalene metabolism

1.00

2-Naphthylamine and 2-Nitronaphtalene metabolism

0.95

Dichloroethylene metabolism

Dichloroethylene metabolism

1.00

Dichloroethylene metabolism

1.00

Xenobiotics

Xenobiotics

1.00

CYP2E1 reactions

0.65

Naphthalene metabolism

Naphthalene metabolism

1.00

Naphthalene metabolism

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

3 EMD Millipore Pathways for CYP2F1

	Dichloroethylene metabolism
	2-Naphthylamine and 2-Nitronaphtalene metabolism
	Naphthalene metabolism

3 GeneGo (Thomson Reuters) Pathways for CYP2F1

	Naphthalene metabolism
	2-Naphthylamine and 2-Nitronaphtalene metabolism
	Dichloroethylene metabolism

3 BioSystems Pathways for CYP2F1

	cytochrome P450
	metapathway biotransformation
	Tryptophan metabolism

5/6 Reactome Pathways for CYP2F1 (see all 6)

	Cytochrome P450 - arranged by substrate type
	Xenobiotics
	Metabolism
	Biological oxidations
	Phase 1 - Functionalization of compounds

1 Kegg Pathway (Kegg details for CYP2F1):

Metabolism of xenobiotics by cytochrome P450

CYP2F1 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for CYP2F1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/53 Interacting proteins for CYP2F1 (ENSP00000333534⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 53)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ADH1A	ENSP00000209668⁴	STRING: ENSP00000209668
ADH1B	ENSP00000306606⁴	STRING: ENSP00000306606
ALDH1A3	ENSP00000332256⁴	STRING: ENSP00000332256
EPHX1	ENSP00000272167⁴	STRING: ENSP00000272167
GSTA1	ENSP00000335620⁴	STRING: ENSP00000335620

About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006805	xenobiotic metabolic process	TAS	--
GO:0009636	response to toxin	IEA	--
GO:0018931	naphthalene metabolic process	IDA	10383923
GO:0018979	trichloroethylene metabolic process	IEA	--
GO:0044281	small molecule metabolic process	TAS	--

CYP2F1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CYP2F1

10/50 HMDB Compounds for CYP2F1 (see all 50) About this table

Compound	Synonyms	CAS #	PubMed Ids
10-HETE	10-hydroxyeicosa-all-cis-5,8,11,14-tetraenoate (see all 2)	167697-52-1	--
11,12,15-THETA	11,12,15-Trihydroxyicosatrienoic acid (see all 5)	--	--
11,12-Epoxyeicosatrienoic acid	10-(3-(2-octenyl)oxiranyl)-5,8-Decadienoic acid (see all 15)	81276-02-0	--
11,14,15-THETA	(5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoic acid (see all 8)	--	--
11H-14,15-EETA	14,15-Ep-11-HETrE (see all 11)	219535-29-2	--
11beta-Hydroxytestosterone	11beta,17beta-dihydroxyandrost-4-en-3-one	1816-85-9	--
12,13-EpOME	Vernolic acid (see all 12)	--	--
13-HETE	13-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoate (see all 2)	151910-72-4	--
14,15-Epoxy-5,8,11-eicosatrienoic acid	(5Z,8Z,11Z)-14,15-Epoxyicosa-5.8.11-trienoic acid (see all 11)	81276-03-1	--
15(S)-HPETE	(5Z,8Z,11Z,13E)-(15S)-15-Hydroperoxyicosa-5,8,11,13-tetraenoate (see all 8)	70981-96-3	--

Search CenterWatch for drugs/clinical trials and news about CYP2F1 / CP2F1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CYP2F1 gene:

NM_000774.3

Unigene Cluster for CYP2F1:

Cytochrome P450, family 2, subfamily F, polypeptide 1

Hs.558318 [show with all ESTs]

Unigene Representative Sequence: AK298082

7 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000526093(uc021uuv.1) ENST00000531409(uc010xvv.1) ENST00000527768

ENST00000331105(uc002opu.1 uc002opv.1) ENST00000532164 ENST00000534009

ENST00000439903

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Additional cDNA sequence:

AK296884.1 AK298082.1 AK316498.1 BC109056.1 BC109057.1 J02906.1

4 DOTS entries:

DT.102624 DT.121503462 DT.99996904 DT.95094345

7 AceView cDNA sequences:

NM_000774 CB306453 J02906 BE829867 BM968957 BI063387 CD688412

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for CYP2F1 About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4a	·	4b	^	5	^	6	^	7	^	8	^	9	^	10
SP1:
SP2:

ECgene alternative splicing isoforms for CYP2F1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CYP2F1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

CYP2F1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

3 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Liver

Liver Lobule

Periportal Hepatocytes

Liver

Adipose

Body Subcutaneous White Adipose

Adipose

Lung

Trachea

Lung

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See CYP2F1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CYP2F1

SOURCE GeneReport for Unigene cluster: Hs.558318

UniProtKB/Swiss-Prot: CP2F1_HUMAN, P24903

Tissue specificity: Expressed in lung. Rarely detected in liver and placenta

SABiosciences Expression via Pathway-Focused PCR Arrays including CYP2F1:

Drug Metabolism: Phase I Enzymes in human mouse rat

Cellular Stress Responses in human mouse rat

Drug Metabolism in human mouse rat

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CYP2F1 gene from 2/9 species (see all 9) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	CYP2F1⁶ --	--	60(a) 40(a)	1 ↔ 1 possible ortholog	LGf(2899785-2917334) 2(106117970-106140417)
zebrafish (Danio rerio)	Actinopterygii	cyp2y3⁶ CU928854.1⁶	--	47(a) 46(a)	many ↔ many many ↔ many	15(65144-71354) 15(54297-58832)

ENSEMBL Gene Tree for CYP2F1 (if available)
TreeFam Gene Tree for CYP2F1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CYP2F1 gene

CYP2W1² CYP2C8² CYP2A7² CYP2R1² CYP2U1² CYP2J2² CYP2E1² CYP2D6²

CYP2B7P1² CYP2A6² CYP2B6² CYP2C19² CYP2S1² CYP2C9² CYP2C18² CYP2A13²

18/29 SIMAP similar genes for CYP2F1 using alignment to 4 protein entries: CP2F1_HUMAN (see all proteins) (see all similar genes):

CYP2A13 CYP2A6 CYP2A6V2 CYP2C19 CYP 2C CYP2C18

CYP2E1 CYP2B7 CYP2C9 CYP2A7 CYP2B CYP2C8

CYP2G1P CYP2S1 CYP2B6 CYP2J2 DKFZp686I24235 CYP2W1

CYP2F1 for paralogs About GeneDecksing

4 Pseudogenes.org Pseudogenes for CYP2F1
PGOHUM00000234318 PGOHUM00000259331 PGOHUM00000258061 PGOHUM00000234700

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

UniProtKB/Swiss-Prot: CP2F1_HUMAN, P24903

Polymorphism: Eight non disease-associated alleles are known: CYP2F1*1, CYP2F1*2A, CYP2F1*2B, CYP2F1*3, CYP2F1*4,

CYP2F1*5A, CYP2F1*5B and CYP2F1*6. The sequence shown corresponds to allele CYP2F1*1

SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs79925814^1,2	F,	--	38050631(+)	`GAGCTA/GTATAA`	1	--	us2k¹		1		WA	118
rs62117443^1,2		--	38050675(+)	`CCTGCC/ACCAAC`	1	--	us2k¹		2		NA	122
rs1709115^1,2	C,F,A,H,	--	38051475(-)	`AGCCAA/GGCTGA`	1	--	us2k¹		19		NS EA NA WA CSA	2221
rs62117444^1,2		--	38051750(+)	`ACCCAC/TGGCAA`	1	--	us2k¹		2		NA	122
rs114141619^1,2	C,F,	--	38051849(+)	`GGGCCA/CCTCGG`	1	--	us2k¹		1		WA	118
rs112123000^1,2	F	--	38051929(+)	`CAGCCG/CCCATC`	1	--	us2k¹		2		CSA	4
rs34903717^1,2	C,	--	38051958(+)	`AGCCC-/CATGAC`	1	--	us2k¹		0	--	--	--	--
rs1709113^1,2	C,	--	38052020(-)	`TCTTTC/GTTTGT`	1	--	us2k¹ trp³		2		WA	120
rs1645711^1,2	C,F,H,	--	38052077(+)	`TCCCAC/TGGCAC`	1	--	us2k¹		13		NS EA WA NA	1528
rs77890115^1,2	F,	--	38052111(+)	`AGGGCC/TGCAGG`	1	--	us2k¹		1		NA	120

HapMap Linkage Disequilibrium report for CYP2F1 (41620337 - 41634281 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for CYP2F1
1 CNV: 67548
Human Gene Mutation Database (HGMD): CYP2F1

Locus Specific Mutation Databases (LSDB): CYP2F1

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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CYP2F1 for disorders           About GeneDecksing

OMIM gene information: 124070    OMIM disorders: --

4 diseases for CYP2F1:    About MalaCards

cholesterol vaccinia ovarian cancer colorectal cancer

1 Novoseek disease relationship for CYP2F1 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
metastasis	0	2	15897573 (1)

Human Genome Epidemiology (HuGE) Navigator: CYP2F1 (6 documents)

Export disorders for CYP2F1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for CYP2F1 gene, integrated from 9 sources (see all 32):
(articles sorted by number of sources associating them with CYP2F1)

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Identification and cross-species comparisons of CYP2F subfamily genes in mammals. (PubMed id 11827709)^{1, 2, 9} Chen N.... Hoffman S.M.G. (2002)
The human CYP2F gene subfamily: identification of a cDNA encoding a new cytochrome P450, cDNA-directed expression, and chromosome mapping. (PubMed id 1974816)^{1, 2, 9} Nhamburo P.T....Gonzalez F.J. (1990)
Molecular analysis of the CYP2F1 gene: identification of a frequent non-functional allelic variant. (PubMed id 17327131)^{1, 2} Tournel G....Lo-Guidice J.-M. (2007)
Specific dehydrogenation of 3-methylindole and epoxidation of naphthalene by recombinant human CYP2F1 expressed in lymphoblastoid cells. (PubMed id 10383923)^{1, 2} Lanza D.L.... Yost G.S. (1999)
Expression of xenobiotic-metabolizing cytochrome P450 forms in human full-term placenta. (PubMed id 8619884)^{1, 2} Hakkola J....Raunio H. (1996)
CYP2F1 genetic polymorphism: identification of interethnic variations. (PubMed id 17943660)^{1, 9} Tournel G....Lo-Guidice J.M. (2007)
Characterization of the human lung CYP2F1 gene and identification of a novel lung-specific binding motif. (PubMed id 12598524)^{1, 9} Carr B.A....Yost G.S. (2003)
Quantification of multiple human cytochrome P450 mRNA molecules using competitive reverse transcriptase-PCR. (PubMed id 9539103)^{1, 9} Andersen M.R....Omiecinski C.J. (1998)
[Polymorphic markers of the CYP1B1 (4326C > G), CY P2F1 (c.14_15insC), CYP2J2 (-76G > T), and CYP2S1 (13106C > T and 13255A > G) genes and genetic predisposition to chronic respiratory diseases induce d by smoking and occupational factors]. (PubMed id 22232929)¹ Akhmadishina L.A....Victorova T.V. (2011)
[The CYP1B1 and CYP2F1 genes polymorphisms frequency in three ethnic groups of Bashkortostan and chronic obstructive pulmonary disea se patients] (PubMed id 20198857)¹ Korytina G.F....Viktorova T.V. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 1572	HGNC: 2632	AceView: CYP2F1	Ensembl:ENSG00000197446	euGenes: HUgn1572
ECgene: CYP2F1	Kegg: 1572	H-InvDB: CYP2F1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for CYP2F1	Pharmacogenomics, SNPs, Pathways
Cytochrome P450 Allele Nomenclature Committee	http://www.cypalleles.ki.se/cyp2f1.htm

Intellectual Property for CYP2F1 gene
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Patent Information for CYP2F1 gene:
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cytochrome P450, family 2, subfamily F, polypeptide 1

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cytochrome P450, family 2, subfamily F, polypeptide 1

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