CYP2E1 Gene
protein-coding GIFtS : 69 GCID: GC10 P135352
cytochrome P450, family 2, subfamily E, polypeptide 1 cytochrome P450, subfamily IIE (ethanol-inducible), polypeptide... CYP2E )
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Aliasesfor CYP2E1 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Cytochrome P450, Family 2, Subfamily E, Polypeptide 1 1 2 P450-J2 CYP2E1 2 3 5 Cytochrome P450 2E12 Cytochrome P450, Subfamily IIE (Ethanol-Inducible), Polypeptide 11 2 Flavoprotein-Linked Monooxygenase2 Cytochrome P450-J2 3 Microsomal Monooxygenase2 4-Nitrophenol 2-Hydroxylase2 3 Xenobiotic Monooxygenase2 CYPIIE12 3 EC 1.14.13.-3 P450C2E2 5 EC 1.14.13.N71 CPE12 EC 1.14.14.18
Export aliases for CYP2E1 gene to outside databases Previous GC identifers: GC10P134255 GC10P134470 GC10P135256 GC10P134814 GC10P135229 GC10P128882
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Summariesfor CYP2E1 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for CYP2E1 : This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is induced by ethanol, the diabetic state, and starvation. The enzyme metabolizes both endogenous substrates, such as ethanol, acetone, and acetal, as well as exogenous substrates including benzene, carbon tetrachloride, ethylene glycol, and nitrosamines which are premutagens found in cigarette smoke. Due to its many substrates, this enzyme may be involved in such varied processes as gluconeogenesis, hepatic cirrhosis, diabetes, and cancer. (provided by RefSeq, Jul 2008) UniProtKB/Swiss-Prot: CP2E1_HUMAN, P05181 Function : Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number ofdrugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms Gene Wiki entry for CYP2E1 PharmGKB "VIP " summary for
CYP2E1
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Genomic Viewsfor CYP2E1 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,miRBase ,UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000010.10 NC_018921.1 NT_008818.16 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the CYP2E1 gene promoter:AhR Max1 STAT1 AP-1 ATF-2 Lmo2 HSF2 ARP-1 c-Jun c-Myc Other transcription factors Search SABiosciences Chromatin IP Primers for CYP2E1 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 10q24.3-qter Ensembl cytogenetic band: 10q26.3 HGNC chromosome: 10 CYP2E1 Gene in genomic location: bands according to Ensembl, locations according to
Entrez Gene Ensembl GeneLoc information about chromosome 10 GeneLoc Exon Structure
GeneLoc location for GC10P135352: view genomic region
(about GC identifiers )
Start: 135,333,910 bp from pter End:
135,374,724 bp from pter
Size: 40,815 bases Orientation:
plus strand
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Proteinsfor CYP2E1 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: CP2E1_HUMAN, P05181 See
protein sequence )Recommended Name: Size : 493 amino acids; 56849 DaCofactor : Heme groupSubcellular location : Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheralmembrane protein
6 PDB 3D structures from :3E4E (3D) 3E6I (3D) 3GPH (3D) 3KOH (3D) 3LC4 (3D) 3T3Z (3D) Secondary accessions : Q5VZD5 Q9UK47Explore the universe of human proteins at neXtProt for CYP2E1: NX_P05181 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_P05181 4/7 DME Specific Peptides for CYP2E1 (P05181 ) (see all 7 )CYP2E1 Protein expression data from MOPED and PaxDb : About this image REFSEQ proteins: NP_000764.1 ENSEMBL proteins: ENSP00000440689 ENSP00000437799 ENSP00000444958 ENSP00000412754 ENSP00000397299 ENSP00000252945 Reactome Protein details: P05181 Human Recombinant Protein Products: Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6 ): About this table
About GeneDecksing CYP2E1 Antibody Products: Assay Products for CYP2E1:
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Protein
Domains /for CYP2E1 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section About GeneDecksing 4 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry P05181 ProtoNet protein and cluster: P05181
2 Blocks protein families : IPB002401 IPB008070 UniProtKB/Swiss-Prot: CP2E1_HUMAN, P05181 Similarity : Belongs to the cytochrome P450 family
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Functionfor CYP2E1 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: CP2E1_HUMAN, P05181 Function : Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number ofdrugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms Catalytic activity : 4-nitrophenol + NADPH + O(2) = 4-nitrocatechol + NADP(+) + H(2)OInduction : By ethanol and isoniazidEnzyme Numbers (IUBMB): EC 1.14.13.n7 1 EC 1.14.14.1 2 EC 1.14.13.- 1
Clone Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 3 )human mouse rat OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: CYP2E1 (NM_000773 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CYP2E1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat CYP2E1
In Situ AssayAdvanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYP2E1
Gene Ontology (GO): 5/10 molecular function terms (GO ID links to tree view) (see all 10 ): About this table
About GeneDecksing Animal Models: Cyp2e1 tm1Gonz for CYP2E16 MGI mutant phenotypes (inferred from 1 allele(MGI details for Cyp2e1) :About GeneDecksing
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Pathways & Interactionsfor CYP2E1 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways - 5/22 super-pathways (see all 22 ) About this table See pathways by source Super-pathway contained gene-specific pathways 1 Acetaminophen Pathway, Pharmacokinetics 2 Xenobiotics 3 Cytochrome P450 - arranged by substrate type 4 Arachidonic acid metabolism 5 Retinol metabolism
Pathway sources See GeneCards unified pathways Show all pathways 5/7 (see all 7 )5/6 (see all 6 )5/10 (see all 10 ) 5/6 (see all 6 )5/7 CYP2E1 (see all 7 )5 (Kegg details for CYP2E1) :About GeneDecksing Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CYP2E1 STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)5/116 Interacting proteins for CYP2E1 (P05181 3 ENSP00000252945 4 via UniProtKB, MINT, STRING , and/or I2D (see all 116 )About this table Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12 ): About this table
About GeneDecksing
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Drugs & Compoundsfor CYP2E1 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section About GeneDecksing Browse Tocris compounds for CYP2E1 10/47 HMDB Compounds for CYP2E1 (see all 47 )About this table Compound Synonyms
CAS
# PubMed Ids 11,12,15-THETA 11,12,15-Trihydroxyicosatrienoic acid (see all 5 ) -- -- 11,12-Epoxyeicosatrienoic acid 10-(3-(2-octenyl)oxiranyl)-5,8-Decadienoic acid (see all 15 ) 81276-02-0 -- 11,14,15-THETA (5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoic acid (see all 8 ) -- -- 11H-14,15-EETA 14,15-Ep-11-HETrE (see all 11 ) 219535-29-2 -- 12,13-EpOME Vernolic acid (see all 12 ) -- -- 13-HETE 13-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoate (see all 2 ) 151910-72-4 -- 14,15-Epoxy-5,8,11-eicosatrienoic acid (5Z,8Z,11Z)-14,15-Epoxyicosa-5.8.11-trienoic acid (see all 11 ) 81276-03-1 -- 15(S)-HPETE (5Z,8Z,11Z,13E)-(15S)-15-Hydroperoxyicosa-5,8,11,13-tetraenoate (see all 8 ) 70981-96-3 -- 15H-11,12-EETA 15-Hydroxy-11,12-epoxyeicosatrienoic acid (see all 9 ) 877878-78-9 -- 16(R)-HETE 16R-HETE (see all 4 ) -- --
10/112 DrugBank Compounds for CYP2E1 (see all 112 )About this table 10/162 Novoseek chemical compound relationships for CYP2E1 gene (see all 162 ) About this table
Compound
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
chlorzoxazone
95.3
190
16393464 (4), 9531516 (4), 15255802 (4), 11602665 (3) (see all 91 )
6-hydroxychlorzoxazone
91.7
22
10490907 (2), 12585472 (2), 17119944 (1), 9322481 (1) (see all 16 )
rsai
88
55
8547826 (4), 7534543 (4), 9825833 (3), 8977352 (2) (see all 33 )
dimethylnitrosamine
80.9
23
8622629 (1), 9675256 (1), 17567472 (1), 18378564 (1) (see all 20 )
p-nitrophenol
80.7
42
15135088 (4), 17584020 (2), 14669323 (2), 14556645 (2) (see all 28 )
furafylline
77
2
9394024 (1), 10821163 (1)
acetaldehyde
76.3
54
16365683 (4), 16553429 (4), 17590984 (2), 12940444 (2) (see all 27 )
nitrosamines
75
29
15242818 (4), 17146594 (2), 9806171 (2), 18818195 (1) (see all 18 )
chlorodifluoroacetic acid
74.7
2
12451447 (1)
epoxide
74.3
31
8232220 (2), 16039674 (2), 8377657 (1), 8236284 (1) (see all 27 )
CYP2E1 / CP2E1
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Transcriptsfor CYP2E1 gene (Secondary structures according to
fRNAdb ,Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC , GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,EMD Millipore ,
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for CYP2E1 gene: NM_000773.3 Unigene Cluster for CYP2E1:
Cytochrome P450, family 2, subfamily E, polypeptide 1 Hs.12907 [show with all ESTs ] Unigene Representative Sequence: NM_000773 10 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000463117 ENST00000541261 ENST00000477500 ENST00000541080 ENST00000421586 ENST00000418356 ENST00000480558 ENST00000368520 (uc001lnl.1 ) ENST00000469258 ENST00000252945 (uc001lnj.1 uc001lnk.1 uc009ybl.1 uc009ybm.1 )Clone OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 3 )human mouse rat OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: CYP2E1 (NM_000773 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CYP2E1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat CYP2E1
Additional cDNA sequence: AF084225.1 AF182276.1 AJ853939.1 AJ853940.1 AJ877238.1 AK290822.1 BC067433.1 BC067435.1 DQ149222.1 J02625.1 S77873.1
14 DOTS entries : DT.444621 DT.99987835
DT.92449334 DT.121278796 DT.91699780 DT.92449330 DT.100772634 DT.100798406 DT.40296356 DT.40227062 DT.92449335 DT.100798402 DT.100798404 DT.92449336 24/154 AceView cDNA sequences (see all 154 ):
BX449120 CR622294 AL558632 T64762 BQ879759 AL531476 CR618024 BX951454 CR603555 CR592801 CB124845 CR621945 CB154278 CR626746 AV697094 CA311379 CR626742 AV686395 AV697059 BG618593 AV697100 AW204407 H46449 T16253 GeneLoc Exon Structure 5/8 Alternative Splicing Database (ASD) splice patterns (SP) for CYP2E1 (see all 8 ) About this scheme ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b SP1 : - - - SP2 : - - - - - SP3 : - - - - - - SP4 : - - - - - - - - SP5 :
ECgene alternative splicing isoforms for CYP2E1
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Expression for CYP2E1 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section CYP2E1 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: AGTGTGTGGA
About this image CYP2E1 expression in embryonic tissues and stem cells About this table See CYP2E1 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for CYP2E1 SOURCE GeneReport for Unigene cluster: Hs.12907 SABiosciences Expression via Pathway-Focused PCR Arrays including CYP2E1 (see all 6 ): Primer OriGene genome-wide validated SYBR primer pairs in human mouse rat Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat In Situ Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYP2E1
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Orthologsfor CYP2E1 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section Orthologs for CYP2E1 gene from 3/11 species (see all 11 ) About this table
ENSEMBL Gene Tree for CYP2E1 (if available)TreeFam Gene Tree for CYP2E1 (if available)
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Paralogsfor CYP2E1 gene (Paralogs according to
1 HomoloGene ,2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for CYP2E1 gene CYP2W1 2 CYP2C8 2 CYP2F1 2 CYP2A7 2 CYP2R1 2 CYP2U1 2 CYP2J2 2 CYP2D6 2 CYP2B7P1 2 CYP2A6 2 CYP2B6 2 CYP2C19 2 CYP2S1 2 CYP2C9 2 CYP2C18 2 CYP2A13 2 18/43 SIMAP similar genes for CYP2E1 using alignment to 12 protein entries: CP2E1_HUMAN (see all proteins )
(see all similar genes ):CYP2C19 CYP 2C CYP2C9 CYP2C8 CYP2C18 CYP2G1P CYP2A13 CYP2A6 CYP2A6V2 CYP2F1 CYP2B CYP2A7 CYP2B6 CYP2B7 DKFZp686I24235 CYP2S1 CYP2R1 CYP2J2 About GeneDecksing
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Genomic Variantsfor CYP2E1 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical Chr 10 pos Sequence # AA Type More # Allele Pop Total More
and Proteopedia 
for CYP2E1:
Browse Tocris compounds for 
Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine 
Anatomical Compartment 
Negative
Selective marker
In-situ hybridization