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Aliases for CYP2E1 Gene

Aliases for CYP2E1 Gene

  • Cytochrome P450, Family 2, Subfamily E, Polypeptide 1 2 3
  • CYP2E 3 4 6
  • Cytochrome P450, Subfamily IIE (Ethanol-Inducible), Polypeptide 1 2 3
  • 4-Nitrophenol 2-Hydroxylase 3 4
  • Cytochrome P450-J 3 4
  • P450C2E 3 6
  • CYPIIE1 3 4
  • Flavoprotein-Linked Monooxygenase 3
  • Microsomal Monooxygenase 3
  • Xenobiotic Monooxygenase 3
  • Cytochrome P450 2E1 3
  • EC 1.14.13.n7 4
  • EC 1.14.14.1 64
  • EC 1.14.13.- 4
  • P450-J 3
  • CPE1 3

External Ids for CYP2E1 Gene

Previous Symbols for CYP2E1 Gene

  • CYP2E

Summaries for CYP2E1 Gene

Entrez Gene Summary for CYP2E1 Gene

  • This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is induced by ethanol, the diabetic state, and starvation. The enzyme metabolizes both endogenous substrates, such as ethanol, acetone, and acetal, as well as exogenous substrates including benzene, carbon tetrachloride, ethylene glycol, and nitrosamines which are premutagens found in cigarette smoke. Due to its many substrates, this enzyme may be involved in such varied processes as gluconeogenesis, hepatic cirrhosis, diabetes, and cancer. [provided by RefSeq, Jul 2008]

GeneCards Summary for CYP2E1 Gene

CYP2E1 (Cytochrome P450, Family 2, Subfamily E, Polypeptide 1) is a Protein Coding gene. Diseases associated with CYP2E1 include alcoholic hepatitis and drug-induced hepatitis. Among its related pathways are GPCR Pathway and Metabolism. GO annotations related to this gene include enzyme binding and iron ion binding. An important paralog of this gene is CYP2C19.

UniProtKB/Swiss-Prot for CYP2E1 Gene

  • Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms

Gene Wiki entry for CYP2E1 Gene

PharmGKB "VIP" Summary for CYP2E1 Gene

No data available for Tocris Summary , fRNAdb sequence ontologies and piRNA Summary for CYP2E1 Gene

Genomics for CYP2E1 Gene

Genomic Location for CYP2E1 Gene

Start:
133,520,406 bp from pter
End:
133,561,220 bp from pter
Size:
40,815 bases
Orientation:
Plus strand

Genomic View for CYP2E1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CYP2E1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYP2E1 Gene

Regulatory Elements for CYP2E1 Gene

Proteins for CYP2E1 Gene

  • Protein details for CYP2E1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P05181-CP2E1_HUMAN
    Recommended name:
    Cytochrome P450 2E1
    Protein Accession:
    P05181
    Secondary Accessions:
    • Q5VZD5
    • Q6NWT9
    • Q9UK47

    Protein attributes for CYP2E1 Gene

    Size:
    493 amino acids
    Molecular mass:
    56849 Da
    Cofactor:
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CYP2E1 Gene

neXtProt entry for CYP2E1 Gene

Proteomics data for CYP2E1 Gene at MOPED

Selected DME Specific Peptides for CYP2E1 Gene

Post-translational modifications for CYP2E1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CYP2E1 Gene

Domains for CYP2E1 Gene

Gene Families for CYP2E1 Gene

HGNC:
  • CYP :Cytochrome P450s
IUPHAR :

UniProtKB/Swiss-Prot:

CP2E1_HUMAN
Family:
  • Belongs to the cytochrome P450 family.:
    • P05181
genes like me logo Genes that share domains with CYP2E1: view

Function for CYP2E1 Gene

Molecular function for CYP2E1 Gene

UniProtKB/Swiss-Prot CatalyticActivity: 4-nitrophenol + NADPH + O(2) = 4-nitrocatechol + NADP(+) + H(2)O.
UniProtKB/Swiss-Prot Function: Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms
UniProtKB/Swiss-Prot Induction: By ethanol and isoniazid

Enzyme Numbers (IUBMB) for CYP2E1 Gene

Gene Ontology (GO) - Molecular Function for CYP2E1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004497 monooxygenase activity IDA 19651758
GO:0005506 iron ion binding IEA --
GO:0008392 arachidonic acid epoxygenase activity IBA --
GO:0008395 steroid hydroxylase activity IBA --
GO:0016491 oxidoreductase activity IDA 16401082
genes like me logo Genes that share ontologies with CYP2E1: view
genes like me logo Genes that share phenotypes with CYP2E1: view

Animal Models for CYP2E1 Gene

MGI Knock Outs for CYP2E1:

miRNA for CYP2E1 Gene

No data available for Transcription Factor Targeting and HOMER Transcription for CYP2E1 Gene

Localization for CYP2E1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYP2E1 Gene

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CYP2E1 Gene COMPARTMENTS Subcellular localization image for CYP2E1 gene
Compartment Confidence
endoplasmic reticulum 5
mitochondrion 3
cytosol 2
extracellular 2
golgi apparatus 2
nucleus 2
peroxisome 2
lysosome 1
plasma membrane 1
vacuole 1

Gene Ontology (GO) - Cellular Components for CYP2E1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005737 cytoplasm IBA --
GO:0005739 mitochondrion IEA --
GO:0005783 endoplasmic reticulum --
GO:0005789 endoplasmic reticulum membrane TAS --
genes like me logo Genes that share ontologies with CYP2E1: view

Pathways for CYP2E1 Gene

genes like me logo Genes that share pathways with CYP2E1: view

Gene Ontology (GO) - Biological Process for CYP2E1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006641 triglyceride metabolic process IEA --
GO:0006805 xenobiotic metabolic process TAS --
GO:0008202 steroid metabolic process IMP 18356043
GO:0010193 response to ozone IEA --
GO:0010243 response to organonitrogen compound IEA --
genes like me logo Genes that share ontologies with CYP2E1: view

Compounds for CYP2E1 Gene

(47) HMDB Compounds for CYP2E1 Gene

Compound Synonyms Cas Number PubMed IDs
11,12,15-THETA
  • 11,12,15-Trihydroxyicosatrienoic acid
Not Available
11,12-Epoxyeicosatrienoic acid
  • 10-(3-(2-octenyl)oxiranyl)-5,8-Decadienoic acid
81276-02-0
11,14,15-THETA
  • (5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoic acid
Not Available
11H-14,15-EETA
  • 14,15-Ep-11-HETrE
219535-29-2
12,13-EpOME
  • Vernolic acid
Not Available

(124) Drugbank Compounds for CYP2E1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Acetaminophen
  • Acetaminofen
103-90-2 enzyme substrate
Aldesleukin
  • IL-2
85898-30-2 enzyme inhibitor
Almotriptan
181183-52-8 enzyme substrate
Alosetron
122852-42-0 enzyme inhibitor
Aminophylline
  • Aminophyllin
317-34-0 enzyme substrate

(162) Novoseek inferred chemical compound relationships for CYP2E1 Gene

Compound -log(P) Hits PubMed IDs
chlorzoxazone 95.3 138
6-hydroxychlorzoxazone 91.7 18
rsai 88 50
dimethylnitrosamine 80.9 20
p-nitrophenol 80.7 34
genes like me logo Genes that share compounds with CYP2E1: view

Transcripts for CYP2E1 Gene

mRNA/cDNA for CYP2E1 Gene

Unigene Clusters for CYP2E1 Gene

Cytochrome P450, family 2, subfamily E, polypeptide 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CYP2E1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b
SP1: - - -
SP2: - - - - -
SP3: - - - - - -
SP4: - - - - - - - -
SP5:
SP6: -
SP7:
SP8:

Relevant External Links for CYP2E1 Gene

GeneLoc Exon Structure for
CYP2E1
ECgene alternative splicing isoforms for
CYP2E1

Expression for CYP2E1 Gene

mRNA expression in normal human tissues for CYP2E1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CYP2E1 Gene

This gene is overexpressed in Liver (50.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CYP2E1 Gene

SOURCE GeneReport for Unigene cluster for CYP2E1 Gene Hs.12907

genes like me logo Genes that share expressions with CYP2E1: view

Orthologs for CYP2E1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CYP2E1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CYP2E1 37
  • 94 (a)
OneToOne
LOC450857 36
  • 99 (n)
  • 98.29 (a)
cow
(Bos Taurus)
Mammalia CYP2E1 36
  • 80.73 (n)
  • 77.89 (a)
CYP2E1 37
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CYP2E1 36
  • 79.99 (n)
  • 77.28 (a)
CYP2E1 37
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cyp2e1 36
  • 79.45 (n)
  • 78.09 (a)
Cyp2e1 16
Cyp2e1 37
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CYP2E1 37
  • 67 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cyp2e1 36
  • 80.05 (n)
  • 78.7 (a)
Species with no ortholog for CYP2E1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CYP2E1 Gene

ENSEMBL:
Gene Tree for CYP2E1 (if available)
TreeFam:
Gene Tree for CYP2E1 (if available)

Paralogs for CYP2E1 Gene

genes like me logo Genes that share paralogs with CYP2E1: view

Variants for CYP2E1 Gene

Sequence variations from dbSNP and Humsavar for CYP2E1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs743534 -- 133,535,722(-) TGATG(G/T)AAGTA intron-variant
rs743535 -- 133,535,863(-) GAATA(C/T)TGTGC intron-variant
rs915906 -- 133,530,234(+) CTGAG(C/T)ACAGG intron-variant
rs915907 -- 133,533,423(+) GCAGA(A/C)ACTAG intron-variant
rs915908 -- 133,533,455(+) CAGGA(A/G)CCGTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CYP2E1 Gene

Variant ID Type Subtype PubMed ID
nsv528260 CNV Loss 19592680
essv9566 CNV CNV 17122850
nsv428243 CNV Gain 18775914
esv2750853 CNV Gain 17911159
nsv470981 CNV Gain 18288195
dgv35e55 CNV Gain 17911159
dgv329e1 CNV Complex 17122850
nsv7631 CNV Loss 18451855
dgv123n27 CNV Gain 19166990
nsv832041 CNV Gain 17160897
dgv890n71 CNV Gain 21882294
nsv517180 CNV Gain+Loss 19592680
dgv125n27 CNV Gain 19166990
nsv896321 CNV Gain 21882294
nsv469597 CNV Gain 16826518
nsv514545 CNV Gain 21397061
dgv892n71 CNV Gain 21882294
dgv893n71 CNV Gain+Loss 21882294
esv33719 CNV Gain 17666407
esv28562 CNV Gain+Loss 19812545
nsv498746 CNV Loss 21111241
dgv181e199 CNV Deletion 23128226
esv2421904 CNV Duplication 20811451
nsv436819 CNV Insertion 17901297
nsv8752 CNV Gain+Loss 18304495
dgv895n71 CNV Gain 21882294
dgv330e1 CNV Complex 17122850
dgv126n27 CNV Gain 19166990
nsv818790 CNV Gain 17921354
dgv127n27 CNV Gain 19166990
esv2750875 CNV Loss 17911159
dgv36e55 CNV Gain 17911159
dgv896n71 CNV Gain 21882294
dgv897n71 CNV Gain 21882294
nsv832042 CNV Gain 17160897
dgv128n27 CNV Gain 19166990
dgv898n71 CNV Gain 21882294
nsv896380 CNV Gain 21882294
nsv896383 CNV Gain 21882294
dgv899n71 CNV Loss 21882294
nsv896387 CNV Gain 21882294
dgv900n71 CNV Gain 21882294
dgv37e55 CNV Gain 17911159
nsv442594 CNV CNV 18776908
dgv901n71 CNV Loss 21882294
dgv902n71 CNV Gain 21882294
nsv896392 CNV Gain 21882294
dgv903n71 CNV Gain 21882294
dgv904n71 CNV Gain 21882294
dgv905n71 CNV Gain 21882294
dgv331e1 CNV Complex 17122850
nsv482150 CNV Gain 20164927
nsv896401 CNV Gain 21882294
dgv906n71 CNV Gain 21882294
dgv907n71 CNV Gain 21882294
nsv896409 CNV Gain 21882294
dgv129n27 CNV Gain 19166990
dgv8n64 CNV Gain 17921354
nsv819137 CNV Loss 19587683

Relevant External Links for CYP2E1 Gene

HapMap Linkage Disequilibrium report
CYP2E1
Human Gene Mutation Database (HGMD)
CYP2E1
Locus Specific Mutation Databases (LSDB)
CYP2E1
The Human Cytochrome P450 Allele Nomenclature Database
CYP2E1

Disorders for CYP2E1 Gene

(83) Novoseek inferred disease relationships for CYP2E1 Gene

Disease -log(P) Hits PubMed IDs
liver diseases alcoholic 75.5 31
hepatitis halothane 65.9 6
liver diseases 58.5 30
fatty liver alcoholic 58.2 2
fatty liver 56.6 9

Relevant External Links for CYP2E1

Genetic Association Database (GAD)
CYP2E1
Human Genome Epidemiology (HuGE) Navigator
CYP2E1
genes like me logo Genes that share disorders with CYP2E1: view

No data available for UniProtKB/Swiss-Prot for CYP2E1 Gene

Publications for CYP2E1 Gene

  1. Genetic polymorphism of human CYP2E1: characterization of two variant alleles. (PMID: 9058590) Hu Y. … Ingelman-Sundberg M. (Mol. Pharmacol. 1997) 3 4 23
  2. Cytochrome P450-2E1 and glutathione S-transferase mu polymorphisms among Caucasians and mulattoes from Brazil. (PMID: 11198676) GattA!s G.J. … Soares-Vieira J.A. (Occup Med (Lond) 2000) 3 23 49
  3. ADH2 and CYP2E1 genetic polymorphisms: risk factors for alcohol-related birth defects. (PMID: 11259352) McCarver D.G. (Drug Metab. Dispos. 2001) 3 23 49
  4. Genetic polymorphisms in cytochrome P450 (CYP) 1A1, CYP1A2, CYP2E1, glutathione S-transferase (GST) M1 and GSTT1 and susceptibility to prostate cancer in the Japanese population. (PMID: 11275366) Murata M. … Shiraishi T. (Cancer Lett. 2001) 3 23 49
  5. Study of polymorphisms in the CYP2E1 gene in patients with alcoholic pancreatitis. (PMID: 11331106) Yang B. … Kingsnorth A.N. (Alcohol 2001) 3 23 49

Products for CYP2E1 Gene

Sources for CYP2E1 Gene

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