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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CYP2E1 Gene

protein-coding GIFtS: 69
GCID: GC10P135352

cytochrome P450, family 2, subfamily E, polypeptide 1

(Previous names: cytochrome P450, subfamily IIE (ethanol-inducible), polypeptide...)
(Previous symbol: CYP2E)

Explore 119 diseases affiliated with
CYP2E1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Cytochrome P450, Family 2, Subfamily E, Polypeptide 1¹ ²		P450-J²
CYP2E¹ ² ³ ⁵		Cytochrome P450 2E1²
Cytochrome P450, Subfamily IIE (Ethanol-Inducible), Polypeptide 1¹ ²		Flavoprotein-Linked Monooxygenase²
Cytochrome P450-J² ³		Microsomal Monooxygenase²
4-Nitrophenol 2-Hydroxylase² ³		Xenobiotic Monooxygenase²
CYPIIE1² ³		EC 1.14.13.-³
P450C2E² ⁵		EC 1.14.13.N7¹
CPE1²		EC 1.14.14.1⁸

External Ids:	HGNC: 2631¹	Entrez Gene: 1571²	Ensembl: ENSG00000130649⁷	OMIM: 124040⁵	UniProtKB: P05181³

Export aliases for CYP2E1 gene to outside databases

Previous GC identifers: GC10P134255 GC10P134470 GC10P135256 GC10P134814 GC10P135229 GC10P128882

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CYP2E1:

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are

monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and

other lipids. This protein localizes to the endoplasmic reticulum and is induced by ethanol, the diabetic state, and

starvation. The enzyme metabolizes both endogenous substrates, such as ethanol, acetone, and acetal, as well as

exogenous substrates including benzene, carbon tetrachloride, ethylene glycol, and nitrosamines which are premutagens

found in cigarette smoke. Due to its many substrates, this enzyme may be involved in such varied processes as

gluconeogenesis, hepatic cirrhosis, diabetes, and cancer. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CP2E1_HUMAN, P05181

Function: Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of

drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms

Gene Wiki entry for CYP2E1

PharmGKB "VIP" summary for CYP2E1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000010.10 NC_018921.1 NT_008818.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CYP2E1 gene promoter:
AhR Max1 STAT1 AP-1 ATF-2 Lmo2 HSF2 ARP-1 c-Jun c-Myc
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CYP2E1 promoter sequence

Search SABiosciences Chromatin IP Primers for CYP2E1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CYP2E1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q24.3-qter Ensembl cytogenetic band: 10q26.3 HGNC chromosome: 10

CYP2E1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CYP2E1 gene location

GeneLoc information about chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10P135352: view genomic region (about GC identifiers)

Start:	135,333,910 bp from pter	End:	135,374,724 bp from pter
Size:	40,815 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CP2E1_HUMAN, P05181 (See protein sequence)

Recommended Name: Cytochrome P450 2E1

Size: 493 amino acids; 56849 Da

Cofactor: Heme group

Subcellular location: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral

membrane protein

6 PDB 3D structures from and Proteopedia for CYP2E1:

3E4E (3D)

3E6I (3D)

3GPH (3D)

3KOH (3D)

3LC4 (3D)

3T3Z (3D)

Secondary accessions: Q5VZD5 Q9UK47

Explore the universe of human proteins at neXtProt for CYP2E1: NX_P05181

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P05181

4/7 DME Specific Peptides for CYP2E1 (P05181) (see all 7)

AGTETTS

PFSTGKR

EIDRVIG

VDPKDID

CYP2E1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_000764.1

ENSEMBL proteins:

ENSP00000440689 ENSP00000437799 ENSP00000444958 ENSP00000412754 ENSP00000397299

ENSP00000252945

Reactome Protein details: P05181
Human Recombinant Protein Products for CYP2E1:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	Novus Biologicals CYP2E1 Proteins Novus Biologicals CYP2E1 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for CYP2E1

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000139	Golgi membrane	IEA	--
GO:0005739	mitochondrion	IEA	--
GO:0005783	endoplasmic reticulum	--	--
GO:0005789	endoplasmic reticulum membrane	TAS	--
GO:0005792	microsome	--	--

CYP2E1 for ontologies About GeneDecksing

CYP2E1 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of CYP2E1
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	OriGene Antibodies (see all 3): CYP2E1 OriGene Custom Antibody Services for CYP2E1
	GenScript Custom Superior Antibodies Services for CYP2E1
	Novus Biologicals CYP2E1 Antibodies
	Abcam antibodies for CYP2E1
	Uscn Antibodies for CYP2E1
	ThermoFisher Antibodies for CYP2E1

Assay Products for CYP2E1:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for CYP2E1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CYP2E1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CYP2E1 for domains About GeneDecksing

4 InterPro domains/families:

IPR001128 Cyt_P450

IPR008070 Cyt_P450_E_grp-I_CYP2E-like

IPR017972 Cyt_P450_CS

IPR002401 Cyt_P450_E_grp-I

Graphical View of Domain Structure for InterPro Entry P05181

ProtoNet protein and cluster: P05181

2 Blocks protein families:

IPB002401 E-class P450 group I signature

IPB008070 CYP2E P450 family signature

UniProtKB/Swiss-Prot: CP2E1_HUMAN, P05181

Similarity: Belongs to the cytochrome P450 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: CP2E1_HUMAN, P05181

Function: Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of

drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms

Catalytic activity: 4-nitrophenol + NADPH + O(2) = 4-nitrocatechol + NADP(+) + H(2)O

Induction: By ethanol and isoniazid

Enzyme Numbers (IUBMB): EC 1.14.13.n7¹ EC 1.14.14.1² EC 1.14.13.-¹

Gene Ontology (GO): 5/10 molecular function terms (GO ID links to tree view) (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004497	monooxygenase activity	IDA	19651758
GO:0005506	iron ion binding	IEA	--
GO:0009055	electron carrier activity	IEA	--
GO:0016491	oxidoreductase activity	IDA	16401082
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	--	--

CYP2E1 for ontologies About GeneDecksing

Phenotypes:
6 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Cyp2e1):

behavior/neurological	cardiovascular system	homeostasis/metabolism	liver/biliary system	mortality/aging
tumorigenesis

CYP2E1 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Cyp2e1^tm1Gonz for CYP2E1

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for CYP2E1

miRNA Products:		OriGene 3'-UTR Clone: CYP2E1 Browse MicroRNA Expression Plasmids
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		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CYP2E1 (see all 7) OriGene shRNA RFP: CYP2E1 OriGene siRNA: CYP2E1
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		Sirion Biotech Custom design and validation of potent shRNA sequences against CYP2E1

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for CYP2E1
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Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CYP2E1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CYP2E1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CYP2E1 (NM_000773)
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CYP2E1
		Search LifeMap BioReagents cell lines for CYP2E1
		Sirion Biotech Customized stable knockdown cell line services for CYP2E1 Sirion Biotech Customized inducible knockdown cell line services for CYP2E1 Sirion Biotech Customized stable overexpressing cell line services for CYP2E1 Sirion Biotech Customized inducible overexpressing cell line services for CYP2E1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYP2E1

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/22 super-pathways (see all 22) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Acetaminophen Pathway, Pharmacokinetics

	Pathway_PA165986194 -need delete	1.00			Acetaminophen metabolism	0.43
	Acetaminophen Pathway, Pharmacokinetics	1.00			Acetaminophen metabolism	0.43

Xenobiotics

	Xenobiotics	1.00			Phenytoin Pathway, Pharmacokinetics	0.42
	CYP2E1 reactions	0.65			Carbamazepine Pathway, Pharmacokinetics	0.38

Cytochrome P450 - arranged by substrate type

	Cytochrome P450 - arranged by substrate type	1.00			cytochrome P450	0.73
	Phase 1 - Functionalization of compounds	0.74

Arachidonic acid metabolism

	Arachidonic acid metabolism	0.42			HETE and HPETE biosynthesis and metabolism	0.39
	HETE and HPETE biosynthesis and metabolism	0.39

Retinol metabolism

Retinol metabolism

1.00

Retinol metabolism

0.95

Pathway sources
See GeneCards unified pathways
Show all pathways

5/7 EMD Millipore Pathways for CYP2E1 (see all 7)

	Dichloroethylene metabolism
	2-Naphthylamine and 2-Nitronaphtalene metabolism
	Retinol metabolism
	Naphthalene metabolism
	Acetaminophen metabolism

5/6 GeneGo (Thomson Reuters) Pathways for CYP2E1 (see all 6)

	Retinol metabolism
	HETE and HPETE biosynthesis and metabolism
	Naphthalene metabolism
	2-Naphthylamine and 2-Nitronaphtalene metabolism
	Dichloroethylene metabolism

5/10 BioSystems Pathways for CYP2E1 (see all 10)

	Vitamin A and carotenoid metabolism
	cytochrome P450
	oxidative ethanol degradation III
	acetone degradation I (to methylglyoxal)
	methylglyoxal degradation III

5/6 Reactome Pathways for CYP2E1 (see all 6)

	Cytochrome P450 - arranged by substrate type
	Xenobiotics
	Metabolism
	Biological oxidations
	Phase 1 - Functionalization of compounds

5/7 PharmGKB Pathways for CYP2E1 (see all 7)

	Acetaminophen Pathway, Pharmacokinetics
	Caffeine Pathway, Pharmacokinetics
	Carbamazepine Pathway, Pharmacokinetics
	Pathway_PA165986194 -need delete
	Phenytoin Pathway, Pharmacokinetics

5 Kegg Pathways (Kegg details for CYP2E1):

	Arachidonic acid metabolism
	Linoleic acid metabolism
	Metabolism of xenobiotics by cytochrome P450
	Drug metabolism - cytochrome P450
	Metabolic pathways

CYP2E1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CYP2E1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/116 Interacting proteins for CYP2E1 (P05181³ ENSP00000252945⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 116)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
AMFR	Q9UKV5³, ENSP00000290649⁴	I2D: score=1 STRING: ENSP00000290649
FANCG	O15287³, ENSP00000367910⁴	I2D: score=1 STRING: ENSP00000367910
STUB1	Q9UNE7³, ENSP00000219548⁴	I2D: score=1 STRING: ENSP00000219548
POR	P16435³	I2D: score=3
HSP90AA1	P07900³	I2D: score=1

About this table

Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006641	triglyceride metabolic process	IEA	--
GO:0006805	xenobiotic metabolic process	TAS	--
GO:0008202	steroid metabolic process	IMP	18356043
GO:0010193	response to ozone	IEA	--
GO:0010243	response to organic nitrogen	IEA	--

CYP2E1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CYP2E1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CYP2E1

10/47 HMDB Compounds for CYP2E1 (see all 47) About this table

Compound	Synonyms	CAS #	PubMed Ids
11,12,15-THETA	11,12,15-Trihydroxyicosatrienoic acid (see all 5)	--	--
11,12-Epoxyeicosatrienoic acid	10-(3-(2-octenyl)oxiranyl)-5,8-Decadienoic acid (see all 15)	81276-02-0	--
11,14,15-THETA	(5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoic acid (see all 8)	--	--
11H-14,15-EETA	14,15-Ep-11-HETrE (see all 11)	219535-29-2	--
12,13-EpOME	Vernolic acid (see all 12)	--	--
13-HETE	13-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoate (see all 2)	151910-72-4	--
14,15-Epoxy-5,8,11-eicosatrienoic acid	(5Z,8Z,11Z)-14,15-Epoxyicosa-5.8.11-trienoic acid (see all 11)	81276-03-1	--
15(S)-HPETE	(5Z,8Z,11Z,13E)-(15S)-15-Hydroperoxyicosa-5,8,11,13-tetraenoate (see all 8)	70981-96-3	--
15H-11,12-EETA	15-Hydroxy-11,12-epoxyeicosatrienoic acid (see all 9)	877878-78-9	--
16(R)-HETE	16R-HETE (see all 4)	--	--

10/112 DrugBank Compounds for CYP2E1 (see all 112) About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Chlorzoxazone	Chloroxazone (see all 3)	95-25-0	enzyme	substrate inhibitor	11823761 9890159 19934256
Halothane	2-Bromo-2-Chloro-1,1,1-Trifluoroethane (see all 14)	151-67-7	enzyme	substrate	9103523 19442086 19934256
Trimethadione	Trimetadione (see all 3)	127-48-0	enzyme	substrate	14651673 9879636 19934256
Acetaminophen	Acetaminofen (see all 5)	103-90-2	enzyme	substrate	11095574 19934256
Caffeine	Cafeina (see all 7)	58-08-2	enzyme	substrate	19934256 19515014
Carvedilol	--	72956-09-3	enzyme	substrate	19934256 19515014
Chlorpromazine	--	50-53-3	enzyme	inhibitor	19934256 11996015
Dapsone	Acedapsone (see all 29)	80-08-0	enzyme	substrate	19934256 19515014
Dexmedetomidine	Medetomidina [Spanish] (see all 3)	113775-47-6	enzyme	substrate	18638298 20020418
Ethanol	Absolute Alcohol (see all 34)	64-17-5	enzyme	substrate inhibitor inducer	11996013 19934256

10/162 Novoseek chemical compound relationships for CYP2E1 gene (see all 162) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
chlorzoxazone	95.3	190	16393464 (4), 9531516 (4), 15255802 (4), 11602665 (3) (see all 91)
6-hydroxychlorzoxazone	91.7	22	10490907 (2), 12585472 (2), 17119944 (1), 9322481 (1) (see all 16)
rsai	88	55	8547826 (4), 7534543 (4), 9825833 (3), 8977352 (2) (see all 33)
dimethylnitrosamine	80.9	23	8622629 (1), 9675256 (1), 17567472 (1), 18378564 (1) (see all 20)
p-nitrophenol	80.7	42	15135088 (4), 17584020 (2), 14669323 (2), 14556645 (2) (see all 28)
furafylline	77	2	9394024 (1), 10821163 (1)
acetaldehyde	76.3	54	16365683 (4), 16553429 (4), 17590984 (2), 12940444 (2) (see all 27)
nitrosamines	75	29	15242818 (4), 17146594 (2), 9806171 (2), 18818195 (1) (see all 18)
chlorodifluoroacetic acid	74.7	2	12451447 (1)
epoxide	74.3	31	8232220 (2), 16039674 (2), 8377657 (1), 8236284 (1) (see all 27)

Search CenterWatch for drugs/clinical trials and news about CYP2E1 / CP2E1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CYP2E1 gene:

NM_000773.3

Unigene Cluster for CYP2E1:

Cytochrome P450, family 2, subfamily E, polypeptide 1

Hs.12907 [show with all ESTs]

Unigene Representative Sequence: NM_000773

10 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000463117 ENST00000541261 ENST00000477500 ENST00000541080 ENST00000421586

ENST00000418356 ENST00000480558 ENST00000368520(uc001lnl.1) ENST00000469258

ENST00000252945(uc001lnj.1 uc001lnk.1 uc009ybl.1 uc009ybm.1)

miRNA Products:		OriGene 3'-UTR Clone: CYP2E1 Browse OriGene MicroRNA Expression Plasmids
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Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CYP2E1
		Sirion Biotech Custom design and validation of potent shRNA sequences against CYP2E1

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CYP2E1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CYP2E1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CYP2E1 (NM_000773)
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CYP2E1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CYP2E1

Additional cDNA sequence:

AF084225.1 AF182276.1 AJ853939.1 AJ853940.1 AJ877238.1 AK290822.1 BC067433.1 BC067435.1

DQ149222.1 J02625.1 S77873.1

14 DOTS entries:

DT.444621 DT.99987835 DT.92449334 DT.121278796 DT.91699780 DT.92449330 DT.100772634 DT.100798406

DT.40296356 DT.40227062 DT.92449335 DT.100798402 DT.100798404 DT.92449336

24/154 AceView cDNA sequences (see all 154):

BX449120 CR622294 AL558632 T64762 BQ879759 AL531476 CR618024 BX951454

CR603555 CR592801 CB124845 CR621945 CB154278 CR626746 AV697094 CA311379

CR626742 AV686395 AV697059 BG618593 AV697100 AW204407 H46449 T16253

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for CYP2E1 (see all 8) About this scheme

ExUns:	1	^	2	^	3a	·	3b	·	3c	^	4a	·	4b	^	5a	·	5b	^	6a	·	6b	^	7a	·	7b	·	7c	^	8	^	9a	·	9b	^	10a	·	10b	^	11a	·	11b
SP1:															-				-												-
SP2:											-		-		-				-												-
SP3:											-		-		-		-		-												-
SP4:											-		-		-				-		-		-						-		-
SP5:

ECgene alternative splicing isoforms for CYP2E1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CYP2E1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGTGTGTGGA

About this image

CYP2E1 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

5 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Liver

Perivenous Hepatocytes

Liver

Adipose

Body Subcutaneous White Adipose

Adipose

Thoracic Perivascular Adipose

Adipose

Visceral White Adipose

Adipose

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See CYP2E1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CYP2E1

SOURCE GeneReport for Unigene cluster: Hs.12907

SABiosciences Expression via Pathway-Focused PCR Arrays including CYP2E1 (see all 6):

Cancer Drug Resistance in human mouse rat

Fatty Liver in human mouse rat

Drug Metabolism: Phase I Enzymes in human mouse rat

Cellular Stress Responses in human mouse rat

Molecular Toxicology PathwayFinder 384HT in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CYP2E1 Browse OriGene validated miRNA SYBR primer pairs
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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CYP2E1 gene from 3/11 species (see all 11) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	F1NAB8_CHICK⁶ Q8QFT4_CHICK⁶ (see all 3)	cytochrome P-450 2C45 (see all 3)	51(a) 48(a) (see all 3)	many ↔ many many ↔ many (see all 3)	6(18655325-18675791) 6(17658074-17660908)
lizard (Anolis carolinensis)	Reptilia	-- -- (see all 17)	--	57(a) 55(a) (see all 17)	many ↔ many many ↔ many (see all 17)	AAWZ02038902(823-8873) 1(16287752-16303321)
zebrafish (Danio rerio)	Actinopterygii	CU928854.1⁶ cyp2y3⁶	-- cytochrome P450, family 2, subfamily Y, polypeptid...	43(a) 43(a)	many ↔ many many ↔ many	15(54297-58832) 15(65144-71354)

ENSEMBL Gene Tree for CYP2E1 (if available)
TreeFam Gene Tree for CYP2E1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CYP2E1 gene

CYP2W1² CYP2C8² CYP2F1² CYP2A7² CYP2R1² CYP2U1² CYP2J2² CYP2D6²

CYP2B7P1² CYP2A6² CYP2B6² CYP2C19² CYP2S1² CYP2C9² CYP2C18² CYP2A13²

18/43 SIMAP similar genes for CYP2E1 using alignment to 12 protein entries: CP2E1_HUMAN (see all proteins) (see all similar genes):

CYP2C19 CYP 2C CYP2C9 CYP2C8 CYP2C18 CYP2G1P

CYP2A13 CYP2A6 CYP2A6V2 CYP2F1 CYP2B CYP2A7

CYP2B6 CYP2B7 DKFZp686I24235 CYP2S1 CYP2R1 CYP2J2

CYP2E1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 10 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs181829638^1,2		--	135338954(+)	`CAAATA/TAAAGC`	1	--	us2k¹		0	--	--	--	--
rs113309369^1,2	C	--	135339115(+)	`GGGCAC/TGCGGG`	1	--	us2k¹		0	--	--	--	--
rs41299398^1,2	C	--	135339122(+)	`CGGGTC/TCCGCC`	1	--	us2k¹		6		NS NA	302
rs3813865^1,2	C,F,A,H	--	135339244(+)	`GCCAAG/CGCTTC`	1	--	us2k¹		22		EA NA NS WA CSA	2476
rs117833299^1,2	F	--	135339251(+)	`CTTCAA/GTTTCA`	1	--	us2k¹		1		EA	120
rs3813866^1,2	C,F	--	135339334(+)	`CCCAAT/AGGGTG`	1	--	us2k¹		13		NA NS CSA WA EA	550
rs185741157^1,2		--	135339360(+)	`CCTGGC/TTGGGC`	1	--	us2k¹		0	--	--	--	--
rs8192766^1,2	C,F,A	--	135339385(+)	`AGGGTT/GCAGGG`	1	--	us2k¹		16		NS NA WA CSA EA	555
rs189272802^1,2		--	135339386(+)	`GGGTTC/TAGGGG`	1	--	us2k¹		0	--	--	--	--
rs180897164^1,2		--	135339436(+)	`CCTCAC/TACTGG`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for CYP2E1 (135333910 - 135374724 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 40 variations for CYP2E1
     40 CNVs (see first 15):
     2896 9170 6852 65825 48476 8673 8672 53803 48474 53842 53981 8670 48483 65826 34537
     48478 3830 53096 48480 34865 53644 75467 48482 9648 37785 9647 2162 75465 48475 29599 53611
     48477 8671 29602 34564 30527 29600 71203 48479 58429
Human Gene Mutation Database (HGMD): CYP2E1

Locus Specific Mutation Databases (LSDB): CYP2E1

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CYP2E1 for disorders           About GeneDecksing

OMIM gene information: 124040    OMIM disorders: --

20/119 diseases for CYP2E1 (see all 119):    About MalaCards

erythropoietic protoporphyria age related macular degeneration iron overload birth defects

patent ductus arteriosus alcoholism non-small cell lung carcinoma laryngeal squamous cell carcinoma

squamous cell carcinoma alcohol abuse malignant pleural mesothelioma nonalcoholic steatohepatitis

cholesterol non-hodgkin lymphoma type 2 diabetes mellitus substance abuse

7 diseases from the University of Copenhagen DISEASES database for CYP2E1:

Liver disease Substance abuse Fatty liver disease Esophageal cancer

Lung cancer Hepatocellular carcinoma Squamous cell carcinoma

10/83 Novoseek disease relationships for CYP2E1 gene (see all 83) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
liver diseases alcoholic	75.5	40	9453426 (7), 11410736 (4), 19157621 (4), 9731720 (3) (see all 15)
hepatitis halothane	65.9	7	8794896 (4), 8902272 (2)
liver diseases	58.5	38	12883487 (2), 19307976 (2), 12743671 (2), 16380384 (2) (see all 24)
fatty liver alcoholic	58.2	2	15670659 (1), 14606109 (1)
fatty liver	56.6	13	14606109 (3), 19307976 (2), 12883487 (1), 15554233 (1) (see all 6)
genetic susceptibility	54.9	8	11751440 (1), 19963114 (1), 9829710 (1), 15138035 (1) (see all 7)
alcoholic cirrhosis	54.8	20	19428381 (2), 11748356 (2), 20171022 (2), 9660317 (1) (see all 9)
liver damage	54.6	14	15554233 (2), 9453426 (2), 9248625 (1), 19191768 (1) (see all 9)
alcoholism	53.8	27	7573775 (3), 9660317 (2), 15902904 (2), 9695719 (2) (see all 12)
cancer lung	46.2	55	9029171 (4), 7534543 (4), 10209943 (3), 18798003 (3) (see all 29)

Genetic Association Database (GAD): CYP2E1
Human Genome Epidemiology (HuGE) Navigator: CYP2E1 (378 documents)

Export disorders for CYP2E1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CYP2E1 gene, integrated from 9 sources (see all 1219):
(articles sorted by number of sources associating them with CYP2E1)

Utopia: connect your pdf to the dynamic
world of online information

Genetic polymorphisms of aldehyde dehydrogenase 2, cytochrome p450 2E1 for liver cancer risk in HCV antibody-positive japanese patients and the variations of CYP2E1 mRNA expression levels in the liver due to its polymorphism. (PubMed id 12940444)^{1, 4, 9} Kato S....Naito Z. (2003)
[Associations of Rsa I polymorphism at the 5' flanking region of CYP2E1 and PON2 148 polymorphism in neonates with preterm delivery] (PubMed id 12939804)^{1, 4, 9} Wu B.Y....Xu X.P. (2003)
[Association of CYP2E1 of PON2311 polymorphisms in neonates with preterm] (PubMed id 12561466)^{1, 4, 9} Liang H.Y....Xu X.P. (2002)
ALDH2 and CYP2E1 genotypes, urinary acetaldehyde excretion and the health consequences in moderate alcohol consumers. (PubMed id 16365683)^{1, 4, 9} Yamada Y....Honda R. (2006)
Genetic polymorphism of human CYP2E1: characterization of two variant alleles. (PubMed id 9058590)^{1, 2, 9} Hu Y.... Ingelman-Sundberg M. (1997)
Effects of dietary intake and genetic factors on hypermethylation of the hMLH1 gene promoter in gastric cancer. (PubMed id 15991278)^{1, 4, 9} Nan H.M....Kim H. (2005)
Effects of genetic polymorphisms in metabolic enzymes on the relationships between 8-hydroxydeoxyguanosine levels in human leukocytes and urinary 1-hydroxypyrene and 2-naphthol concentrations. (PubMed id 14646291)^{1, 4, 9} Kim Y.D....Kim H. (2003)
Association of genetic polymorphisms in CYP2E1, MPO, NQO1, GSTM1, and GSTT1 genes with benzene poisoning. (PubMed id 12460800)^{1, 4, 9} Wan J....Hu G. (2002)
Role of epoxide hydrolase, NAD(P)H:quinone oxidoreductase, cytochrome P450 2E1 or alcohol dehydrogenase genotypes in susceptibility to colorectal cancer. (PubMed id 16039674)^{1, 4, 9} van der Logt E.M....Peters W.H. (2006)
Genetic polymorphisms in the cytochromes P-450 (1A1, 2E1), microsomal epoxide hydrolase and glutathione S-transferase M1, T1, and P1 genes, and their relationship with chronic bronchitis and relapsing pneumonia in children. (PubMed id 15928955)^{1, 4, 9} Korytina G.F....Victorova T.V. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 1571	HGNC: 2631	AceView: CYP2E1	Ensembl:ENSG00000130649	euGenes: HUgn1571
ECgene: CYP2E1	Kegg: 1571	H-InvDB: CYP2E1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CYP2E1	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for CYP2E1	Genetics and Cytogenetics in Oncology and Haematology
Cytochrome P450 Allele Nomenclature Committee	http://www.cypalleles.ki.se/cyp2e1.htm
Wikipedia	http://en.wikipedia.org/wiki/CYP2E1
NIEHS-SNPs	http://egp.gs.washington.edu/data/cyp2e1/

Intellectual Property for CYP2E1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for CYP2E1 gene:
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GeneCards and IP:
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CYP2E1 Gene

cytochrome P450, family 2, subfamily E, polypeptide 1

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CYP2E1 Gene

cytochrome P450, family 2, subfamily E, polypeptide 1

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