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CYP2E1 Gene

protein-coding   GIFtS: 70
GCID: GC10P135352

Cytochrome P450, Family 2, Subfamily E, Polypeptide 1

(Previous names: cytochrome P450, subfamily IIE (ethanol-inducible), polypeptide...)
(Previous symbol: CYP2E)
  See CYP2E1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cytochrome P450, Family 2, Subfamily E, Polypeptide 11 2     P450-J2
CYP2E1 2 3 5     Cytochrome P450 2E12
Cytochrome P450, Subfamily IIE (Ethanol-Inducible), Polypeptide 11 2     Flavoprotein-Linked Monooxygenase2
Cytochrome P450-J2 3     Microsomal Monooxygenase2
4-Nitrophenol 2-Hydroxylase2 3     Xenobiotic Monooxygenase2
CYPIIE12 3     EC 1.14.13.-3
P450C2E2 5     EC 1.14.13.n73
CPE12     EC 1.14.14.18

External Ids:    HGNC: 26311   Entrez Gene: 15712   Ensembl: ENSG000001306497   OMIM: 1240405   UniProtKB: P051813   

Export aliases for CYP2E1 gene to outside databases

Previous GC identifers: GC10P134255 GC10P134470 GC10P135256 GC10P134814 GC10P135229 GC10P128882


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CYP2E1 Gene:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are
monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids
and other lipids. This protein localizes to the endoplasmic reticulum and is induced by ethanol, the diabetic
state, and starvation. The enzyme metabolizes both endogenous substrates, such as ethanol, acetone, and acetal,
as well as exogenous substrates including benzene, carbon tetrachloride, ethylene glycol, and nitrosamines which
are premutagens found in cigarette smoke. Due to its many substrates, this enzyme may be involved in such varied
processes as gluconeogenesis, hepatic cirrhosis, diabetes, and cancer. (provided by RefSeq, Jul 2008)

GeneCards Summary for CYP2E1 Gene:
CYP2E1 (cytochrome P450, family 2, subfamily E, polypeptide 1) is a protein-coding gene. Diseases associated with CYP2E1 include alcoholic hepatitis, and benzene toxicity. GO annotations related to this gene include iron ion binding and enzyme binding. An important paralog of this gene is CYP2W1.

UniProtKB/Swiss-Prot: CP2E1_HUMAN, P05181
Function: Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of
drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms

Gene Wiki entry for CYP2E1 Gene

PharmGKB "VIP" summary for CYP2E1


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NC_018921.2  NT_030059.14  
Regulatory elements:
   Regulatory transcription factor binding sites in the CYP2E1 gene promoter:
         AhR   Max1   STAT1   AP-1   ATF-2   Lmo2   HSF2   ARP-1   c-Jun   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCYP2E1 promoter sequence
   Search Chromatin IP Primers for CYP2E1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CYP2E1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q26.3   Ensembl cytogenetic band:  10q26.3   HGNC cytogenetic band: 10q26.3

CYP2E1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CYP2E1 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P135352:  view genomic region     (about GC identifiers)

Start:
135,333,910 bp from pter      End:
135,374,724 bp from pter
Size:
40,815 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CP2E1_HUMAN, P05181 (See protein sequence)
Recommended Name: Cytochrome P450 2E1  
Size: 493 amino acids; 56849 Da
Cofactor: Heme group
6 PDB 3D structures from and Proteopedia for CYP2E1:
3E4E (3D)        3E6I (3D)        3GPH (3D)        3KOH (3D)        3LC4 (3D)        3T3Z (3D)    
Secondary accessions: Q5VZD5 Q6NWT9 Q9UK47

Explore the universe of human proteins at neXtProt for CYP2E1: NX_P05181

Explore proteomics data for CYP2E1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for CYP2E1 (P05181) (see all 7)
     AGTETTS  PFSTGKR  EIDRVIG  VDPKDID 


    See CYP2E1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000764.1  
    ENSEMBL proteins: 
     ENSP00000440689   ENSP00000437799   ENSP00000444958   ENSP00000412754   ENSP00000397299  
     ENSP00000252945  
    Reactome Protein details: P05181

    CYP2E1 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for CYP2E1

     
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    antibodies-online proteins for CYP2E1 (23 products) 

     
    antibodies-online peptides for CYP2E1

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    antibodies-online antibodies for CYP2E1 (107 products) 

    CYP2E1 Assay Products:

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    Cloud-Clone Corp. CLIAs for CYP2E1
    Search eBioscience for ELISAs for CYP2E1 
    antibodies-online kits for CYP2E1 (35 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CYP: Cytochrome P450s

    IUPHAR Guide to PHARMACOLOGY protein family classification: CYP2E1
    CYP2 family

    4 InterPro protein domains:
     IPR001128 Cyt_P450
     IPR008070 Cyt_P450_E_grp-I_CYP2E-like
     IPR017972 Cyt_P450_CS
     IPR002401 Cyt_P450_E_grp-I

    Graphical View of Domain Structure for InterPro Entry P05181

    ProtoNet protein and cluster: P05181

    2 Blocks protein domains:
    IPB002401 E-class P450 group I signature
    IPB008070 CYP2E P450 family signature


    UniProtKB/Swiss-Prot: CP2E1_HUMAN, P05181
    Similarity: Belongs to the cytochrome P450 family


    Find genes that share domains with CYP2E1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CP2E1_HUMAN, P05181
    Function: Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of
    drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms
    Catalytic activity: 4-nitrophenol + NADPH + O(2) = 4-nitrocatechol + NADP(+) + H(2)O
    Induction: By ethanol and isoniazid

         Enzyme Numbers (IUBMB): EC 1.14.13.n71 EC 1.14.14.12 EC 1.14.13.-1

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004497monooxygenase activity IDA19651758
    GO:0005506iron ion binding IEA--
    GO:0016491oxidoreductase activity IDA16401082
    GO:0016705oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen ----
    GO:0016709oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen TAS18818195
         
    Find genes that share ontologies with CYP2E1           About GenesLikeMe


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Cyp2e1):
     behavior/neurological  cardiovascular system  homeostasis/metabolism  liver/biliary system  mortality/aging 
     tumorigenesis 

    Find genes that share phenotypes with CYP2E1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Cyp2e1tm1Gonz for CYP2E1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CYP2E1
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CYP2E1

    miRNA
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    miRTarBase miRNAs that target CYP2E1:
    hsa-mir-488-3p (MIRT038008), hsa-mir-335-5p (MIRT017817), hsa-mir-132-3p (MIRT021813), hsa-mir-488-5p (MIRT041622)

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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CYP2E1

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYP2E1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CP2E1_HUMAN, P05181: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral
    membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    mitochondrion3
    cytosol2
    extracellular2
    golgi apparatus2
    nucleus2
    peroxisome2
    lysosome1
    plasma membrane1
    vacuole1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0005739mitochondrion IEA--
    GO:0005783endoplasmic reticulum ----
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0031227intrinsic component of endoplasmic reticulum membrane IEA--

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    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CYP2E1 About   (see all 22)  
    See pathways by source

    SuperPathContained pathways About
    1Biological oxidations
    Biological oxidations0.56
    Acetaminophen metabolism0.00
    metapathway biotransformation0.42
    Phenytoin Pathway, Pharmacokinetics0.00
    Tamoxifen metabolism0.00
    2Cytochrome P450 - arranged by substrate type
    Cytochrome P450 - arranged by substrate type0.75
    Xenobiotics0.00
    Phase 1 - Functionalization of compounds0.75
    Fatty Acid Omega Oxidation0.00
    cytochrome P4500.74
    CYP2E1 reactions0.00
    3Arachidonic acid metabolism
    Linoleic acid metabolism0.64
    HETE and HPETE biosynthesis and metabolism0.33
    Arachidonic acid metabolism0.41
    4Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    5Chemical carcinogenesis
    Chemical carcinogenesis0.71
    Drug metabolism - cytochrome P4500.69
    Metabolism of xenobiotics by cytochrome P4500.71


    Find genes that share SuperPaths with CYP2E1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for CYP2E1
        Pancreatic Adenocarcinoma

    Selected GeneGo (Thomson Reuters) Pathways for CYP2E1 (see all 6)
        Retinol metabolism
    HETE and HPETE biosynthesis and metabolism
    Naphthalene metabolism
    2-Naphthylamine and 2-Nitronaphtalene metabolism
    Dichloroethylene metabolism

    Selected BioSystems Pathways for CYP2E1 (see all 11)
        cytochrome P450
    Vitamin A and carotenoid metabolism
    oxidative ethanol degradation III
    methylglyoxal degradation III
    Tamoxifen metabolism


    2 Reactome Pathways for CYP2E1
        Xenobiotics
    CYP2E1 reactions

    Selected PharmGKB Pathways for CYP2E1 (see all 6)
        Acetaminophen Pathway, Pharmacokinetics
    Caffeine Pathway, Pharmacokinetics
    Carbamazepine Pathway, Pharmacokinetics
    Phenytoin Pathway, Pharmacokinetics
    Theophylline Pathway, Pharmacokinetics

    Selected Kegg Pathways  (Kegg details for CYP2E1) (see all 8):
        Steroid hormone biosynthesis
    Arachidonic acid metabolism
    Linoleic acid metabolism
    Metabolism of xenobiotics by cytochrome P450
    Drug metabolism - cytochrome P450

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CYP2E1 (see all 6): 
              Cancer Drug Resistance in human mouse rat
              Fatty Liver in human mouse rat
              Drug Metabolism: Phase I Enzymes in human mouse rat
              Cellular Stress Responses in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CYP2E1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CYP2E1 (P051813 ENSP000002529454) via UniProtKB, MINT, STRING, and/or I2D (see all 118)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AMFRQ9UKV53, ENSP000002906494I2D: score=1 STRING: ENSP00000290649
    FANCGO152873, ENSP000003679104I2D: score=1 STRING: ENSP00000367910
    STUB1Q9UNE73, ENSP000002195484I2D: score=1 STRING: ENSP00000219548
    HSPA4P349323, ENSP000003029614I2D: score=1 STRING: ENSP00000302961
    HSP90AA1P079003, ENSP000003351534I2D: score=1 STRING: ENSP00000335153
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    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006641triglyceride metabolic process IEA--
    GO:0006805xenobiotic metabolic process TAS--
    GO:0008202steroid metabolic process IMP18356043
    GO:0010193response to ozone IEA--
    GO:0010243response to organonitrogen compound IEA--

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    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CYP2E1 (CP2E1)

    Selected HMDB Compounds for CYP2E1 (see all 47)    About this table
    CompoundSynonyms CAS #PubMed Ids
    11,12,15-THETA11,12,15-Trihydroxyicosatrienoic acid (see all 5)----
    11,12-Epoxyeicosatrienoic acid10-(3-(2-octenyl)oxiranyl)-5,8-Decadienoic acid (see all 15)81276-02-0--
    11,14,15-THETA(5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoic acid (see all 8)----
    11H-14,15-EETA14,15-Ep-11-HETrE (see all 11)219535-29-2--
    12,13-EpOMEVernolic acid (see all 12)----
    13-HETE13-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoate (see all 2)151910-72-4--
    14,15-Epoxy-5,8,11-eicosatrienoic acid(5Z,8Z,11Z)-14,15-Epoxyicosa-5.8.11-trienoic acid (see all 11)81276-03-1--
    15(S)-HPETE(5Z,8Z,11Z,13E)-(15S)-15-Hydroperoxyicosa-5,8,11,13-tetraenoate (see all 8)70981-96-3--
    15H-11,12-EETA15-Hydroxy-11,12-epoxyeicosatrienoic acid (see all 9)877878-78-9--
    16(R)-HETE16R-HETE (see all 4)----

    Selected DrugBank Compounds for CYP2E1 (see all 124)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Benzyl alcohol(Hydroxymethyl)benzene (see all 10)100-51-6enzymesubstrate8347164 9065730 9253143 15129551
    ChlorzoxazoneChloroxazone (see all 3)95-25-0enzymesubstrate inhibitor15255802 9890159 9879636
    Halothane2-Bromo-2-Chloro-1,1,1-Trifluoroethane (see all 14)151-67-7enzymesubstrate9103523 19442086 19934256
    TrimethadioneTrimetadione (see all 3)127-48-0enzymesubstrate14651673 9879636 19934256
    AcetaminophenAcetaminofen (see all 5)103-90-2enzymesubstrate11095574 19934256
    CaffeineCafeina (see all 7)58-08-2enzymesubstrate19934256 19515014
    Carvedilol-- 72956-09-3enzymesubstrate19934256 19515014
    Chlorpromazine-- 50-53-3enzymeinhibitor19934256 11996015
    Dapsone1,1'-Sulfonylbis[4-aminobenzene] (see all 8)80-08-0enzymesubstrate19934256 19515014
    DexmedetomidineMedetomidina [Spanish] (see all 3)113775-47-6enzymesubstrate18638298 20020418

    Selected Novoseek inferred chemical compound relationships for CYP2E1 gene (see all 162)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    chlorzoxazone 95.3 190 16393464 (4), 9531516 (4), 15255802 (4), 11602665 (3) (see all 91)
    6-hydroxychlorzoxazone 91.7 22 10490907 (2), 12585472 (2), 17119944 (1), 9322481 (1) (see all 16)
    rsai 88 55 8547826 (4), 7534543 (4), 9825833 (3), 8977352 (2) (see all 33)
    dimethylnitrosamine 80.9 23 8622629 (1), 9675256 (1), 17567472 (1), 18378564 (1) (see all 20)
    p-nitrophenol 80.7 42 15135088 (4), 17584020 (2), 14669323 (2), 14556645 (2) (see all 28)
    furafylline 77 2 9394024 (1), 10821163 (1)
    acetaldehyde 76.3 54 16365683 (4), 16553429 (4), 17590984 (2), 12940444 (2) (see all 27)
    nitrosamines 75 29 15242818 (4), 17146594 (2), 9806171 (2), 18818195 (1) (see all 18)
    chlorodifluoroacetic acid 74.7 2 12451447 (1)
    epoxide 74.3 31 8232220 (2), 16039674 (2), 8377657 (1), 8236284 (1) (see all 27)

    Selected PharmGKB related drug/compound annotations for CYP2E1 gene (see all 18)    About this table
    Drug/compound PharmGKB Annotation
    acetaminophen
    cisplatinCA  
    citalopram
    cyclophosphamideCA  
    cytarabineCA  
    dasatinib
    dexlansoprazole
    dextromethorphan
    diazepam
    esomeprazole



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    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CYP2E1 gene: 
    NM_000773.3  

    Unigene Cluster for CYP2E1:

    Cytochrome P450, family 2, subfamily E, polypeptide 1
    Hs.12907  [show with all ESTs]
    Unigene Representative Sequence: NM_000773
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000463117 ENST00000541261 ENST00000477500 ENST00000541080 ENST00000421586
    ENST00000418356 ENST00000480558 ENST00000368520(uc001lnl.1) ENST00000469258
    ENST00000252945(uc001lnj.1 uc001lnk.1 uc009ybl.1 uc009ybm.1)

    miRNA
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CYP2E1 (NM_000773)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CYP2E1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CYP2E1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CYP2E1
    OriGene qSTAR qPCR primer pairs in human, mouse for CYP2E1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CYP2E1
      QuantiTect SYBR Green Assays in human, mouse, rat CYP2E1
      QuantiFast Probe-based Assays in human, mouse, rat CYP2E1

    Additional mRNA sequence: 

    AF084225.1 AF182276.1 AJ853939.1 AJ853940.1 AJ877238.1 AK290822.1 BC067433.1 BC067435.1 
    DQ149222.1 J02625.1 S77873.1 

    14 DOTS entries:

    DT.444621  DT.99987835  DT.92449334  DT.121278796  DT.91699780  DT.92449330  DT.100772634  DT.100798406 
    DT.40296356  DT.40227062  DT.92449335  DT.100798402  DT.100798404  DT.92449336 

    Selected AceView cDNA sequences (see all 154):

    CB154278 CR621945 BX951454 T64762 CR603555 CR626742 CR592801 AV697094 
    CA311379 CR618024 CB124845 CR622294 AL558632 CR626746 AL531476 BX449120 
    BQ879759 BC067433 AF182276 BG545140 CB111967 BX445313 BG564519 AL564573 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CYP2E1 (see all 8)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b
    SP1:                                            -           -                                   -                                 
    SP2:                                -     -     -           -                                   -                                 
    SP3:                                -     -     -     -     -                                   -                                 
    SP4:                                -     -     -           -     -     -                 -     -                                 
    SP5:                                                                                                                              


    ECgene alternative splicing isoforms for CYP2E1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CYP2E1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGTGTGTGGA
    CYP2E1 Expression
    About this image


    CYP2E1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Liver (Hepatobiliary System)    fully expand to see all 3 entries
             Mature Hepatocytes Liver Lobule
     
     Adipose (Muscoskeletal System)    fully expand to see all 2 entries
             Body Subcutaneous White Adipose
     
     Esophagus (Gastrointestinal Tract)
    CYP2E1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CYP2E1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.12907
        Pathway & Disease-focused RT2 Profiler PCR Arrays including CYP2E1 (see all 6): 
              Cancer Drug Resistance in human mouse rat
              Fatty Liver in human mouse rat
              Drug Metabolism: Phase I Enzymes in human mouse rat
              Cellular Stress Responses in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CYP2E1
    OriGene qSTAR qPCR primer pairs in human, mouse for CYP2E1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CYP2E1
    QuantiTect SYBR Green Assays in human, mouse, rat CYP2E1
    QuantiFast Probe-based Assays in human, mouse, rat CYP2E1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYP2E1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for CYP2E1 gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cyp2e11 , 5 cytochrome P450, family 2, subfamily e, polypeptide more1, 5 79.45(n)1
    78.09(a)1
      7 (85.94 cM)5
    131061  NM_021282.21  NP_067257.11 
     1407638325 


    ENSEMBL Gene Tree for CYP2E1 (if available)
    TreeFam Gene Tree for CYP2E1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CYP2E1 gene
    CYP2W12  CYP2C82  CYP2A62  CYP2F12  CYP2A72  CYP2B62  CYP2C192  CYP2R12  
    CYP2J22  CYP2U12  CYP2S12  CYP2C92  CYP2D62  CYP2C182  CYP2A132  
    Selected SIMAP similar genes for CYP2E1 using alignment to 11 protein entries:     CP2E1_HUMAN (see all proteins) (see all similar genes):
    CYP2C19    CYP 2C    CYP2C9    CYP2C8    CYP2C18    CYP2G1P
    CYP2A13    CYP2A6    CYP2A6V2    CYP2F1    CYP2B    CYP2A7
    CYP2B6    CYP2B7    CYP2S1    DKFZp686I24235    CYP2R1    CYP2J2

    Find genes that share paralogs with CYP2E1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CYP2E1 (see all 33)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs114455931,2
    C,F--135340866(+) ATTGTC/-CTCCC 1 -- us2k18Minor allele frequency- -:0.04NS NA CSA 196
    rs81927741,2
    C--135347873(+) ACCCTC/TGTCGT 1 -- int11Minor allele frequency- T:0.50NA 2
    rs113687241,2
    C--135347875(+) CCCTT-/C/CG/ 
     CGT
    /GTC
    GTTCC
    3 -- int1 cds11CSA 2
    rs665182031,2
    C--135347876(+) CCTTG-/C/GTC 
            
    TTCCT
    2 -- int1 cds10--------
    rs710164591,2
    C--135348373(+) ATTTA-/TTTTTT 1 -- int12Minor allele frequency- T:0.25NA CSA 4
    rs127612341,2
    C,F,A--135349914(+) ATGGAT/CGGACG 1 -- int14Minor allele frequency- C:0.29NA WA CSA 7
    rs618683301,2
    C--135350036(+) GGATGG/TATAGA 1 -- int10--------
    rs1385806731,2
    C--135350036(+) GGATG-/TATA  
            
    GATGG
    1 -- int10--------
    rs1479736061,2
    C--135350490(+) GAATA-/GATG  
     GGTGGAT
    GATGG
    1 -- int10--------
    rs764960081,2
    C--135350491(+) GGATG-/ATGG  
     GTGGATG
    CCCAA
    1 -- int10--------

    HapMap Linkage Disequilibrium report for CYP2E1 (135333910 - 135374724 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for CYP2E1 (see all 59):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv181e199CNV Deletion23128226
    esv2421904CNV Duplication20811451
    nsv436819CNV Insertion17901297
    dgv899n71CNV Loss21882294
    nsv498746CNV Loss21111241
    nsv819137CNV Loss19587683
    esv2750875CNV Loss17911159
    dgv901n71CNV Loss21882294
    nsv528260CNV Loss19592680
    nsv7631CNV Loss18451855

    The Human Cytochrome P450 Allele Nomenclature Database: CYP2E1 
    Human Gene Mutation Database (HGMD): CYP2E1
    Locus Specific Mutation Databases (LSDB): CYP2E1

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CYP2E1
    DNA2.0 Custom Variant and Variant Library Synthesis for CYP2E1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 124040    OMIM disorders: --

    16 diseases for CYP2E1:    
    About MalaCards
    alcoholic hepatitis    benzene toxicity    alcohol-related birth defect    drug-induced hepatitis
    alcoholic liver cirrhosis    cardia cancer    alcohol abuse    liver cirrhosis
    oral cancer    nonalcoholic steatohepatitis    liver disease    erythropoietic protoporphyria
    methemoglobinemia    beta thalassemia    pancreatitis    lung cancer

    6 diseases from the University of Copenhagen DISEASES database for CYP2E1:
    Liver disease     Substance abuse     Fatty liver disease     Esophageal cancer
    Lung cancer     Hepatocellular carcinoma

    Find genes that share disorders with CYP2E1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for CYP2E1 gene (see all 83)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    liver diseases alcoholic 75.5 40 9453426 (7), 11410736 (4), 19157621 (4), 9731720 (3) (see all 15)
    hepatitis halothane 65.9 7 8794896 (4), 8902272 (2)
    liver diseases 58.5 38 12883487 (2), 19307976 (2), 12743671 (2), 16380384 (2) (see all 24)
    fatty liver alcoholic 58.2 2 15670659 (1), 14606109 (1)
    fatty liver 56.6 13 14606109 (3), 19307976 (2), 12883487 (1), 15554233 (1) (see all 6)
    genetic susceptibility 54.9 8 11751440 (1), 19963114 (1), 9829710 (1), 15138035 (1) (see all 7)
    alcoholic cirrhosis 54.8 20 19428381 (2), 11748356 (2), 20171022 (2), 9660317 (1) (see all 9)
    liver damage 54.6 14 15554233 (2), 9453426 (2), 9248625 (1), 19191768 (1) (see all 9)
    alcoholism 53.8 27 7573775 (3), 9660317 (2), 15902904 (2), 9695719 (2) (see all 12)
    cancer lung 46.2 55 9029171 (4), 7534543 (4), 10209943 (3), 18798003 (3) (see all 29)

    Genetic Association Database (GAD): CYP2E1
    Human Genome Epidemiology (HuGE) Navigator: CYP2E1 (378 documents)

    Export disorders for CYP2E1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CYP2E1 gene, integrated from 10 sources (see all 1270) (see top 10):
    (articles sorted by number of sources associating them with CYP2E1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genetic polymorphisms of aldehyde dehydrogenase 2, cytochrome p450 2E1 for liver cancer risk in HCV antibody-positive japanese patients and the variations of CYP2E1 mRNA expression levels in the liver due to its polymorphism. (PubMed id 12940444)1, 4, 9 Kato S....Naito Z. (Scand. J. Gastroenterol. 2003)
    2. Interaction of genetic polymorphisms in cytochrome P450 2E1 and glutathione S-transferase M1 to breast cancer in Taiwanese woman without smoking and drinking habits. (PubMed id 16758119)1, 4, 9 Wu S.H....Tsai L.Y. (Breast Cancer Res. Treat. 2006)
    3. CYP2E1 mRNA expression, genetic polymorphisms in peripheral blood lymphocytes and liver abnormalities in Chinese VCM-exposed workers. (PubMed id 18715838)1, 4, 9 Wang A.H....Xia Z.L. (Int J Occup Med Environ Health 2008)
    4. [Associations of Rsa I polymorphism at the 5' flanking region of CYP2E1 and PON2 148 polymorphism in neonates with preterm delivery]. (PubMed id 12939804)1, 4, 9 Wu B.Y....Xu X.P. (Yi Chuan Xue Bao 2003)
    5. [Association of CYP2E1 of PON2311 polymorphisms in neonates with preterm]. (PubMed id 12561466)1, 4, 9 Liang H.Y....Xu X.P. (Yi Chuan Xue Bao 2002)
    6. Genetic polymorphisms in cytochrome P4502E1, alcohol and aldehyde dehydrogenases and the risk of esophageal squamous cell carcinoma in Gansu Chinese males. (PubMed id 18322963)1, 4, 9 Guo Y.M....Guo Q.H. (World J. Gastroenterol. 2008)
    7. Genetic polymorphisms of NAT2 and CYP2E1 associated with antituberculosis drug-induced hepatotoxicity in Korean patients with pulmonary tuberculosis. (PubMed id 17950035)1, 4, 9 Cho H.J....Lee S.Y. (Tuberculosis (Edinb) 2007)
    8. Cytochrome P450 2E1 genotype and the susceptibility to antituberculosis drug-induced hepatitis. (PubMed id 12668988)1, 4, 9 Huang Y.S....Lee S.D. (Hepatology 2003)
    9. Genetic repeat polymorphism in the regulating region of CYP2E1: frequency and relationship with enzymatic activity in alcoholics. (PubMed id 11410713)1, 4, 9 Plee-Gautier E....Lucas D. (Alcohol. Clin. Exp. Res. 2001)
    10. Expression of cytochrome P4502E1 in human liver: Relationship between genotype and phenotype in Chinese. (PubMed id 18726416)1, 4, 9 Tan W....Lin D. (Sci. China, C, Life Sci. 2001)
    11. Influence of NQO1, ALDH2, and CYP2E1 genetic polymorphisms, smoking, and alcohol drinking on the risk of lung cancer in Koreans. (PubMed id 18798003)1, 4, 9 Eom S.Y....Kim H. (amp 2009)
    12. Associations between CYP2E1 promoter polymorphisms and plasma 1,3-dimethyluric acid/theophylline ratios. (PubMed id 16841220)1, 4, 9 Yoon Y....Song J. (Eur. J. Clin. Pharmacol. 2006)
    13. ALDH2 and CYP2E1 genotypes, urinary acetaldehyde excretion and the health consequences in moderate alcohol consumers. (PubMed id 16365683)1, 4, 9 Yamada Y....Honda R. (J. Hum. Genet. 2006)
    14. CYP2E1 and NQO1 genotypes, smoking and bladder cancer. (PubMed id 12777965)1, 4, 9 Choi J.Y....Kang D. (Pharmacogenetics 2003)
    15. XRCC1, CYP2E1 and ALDH2 genetic polymorphisms and sister chromatid exchange frequency alterations amongst vinyl chloride monomer-exposed polyvinyl chloride workers. (PubMed id 12739102)1, 4, 9 Wong R.H....Cheng T.J. (Arch. Toxicol. 2003)
    16. CYP1A1, CYP2E1 and GSTM1 genetic polymorphisms. The effect of single and combined genotypes on lung cancer susceptibility in Chilean people. (PubMed id 11675150)1, 4, 9 QuiA+ones L....Gil L. (Cancer Lett. 2001)
    17. Genetic polymorphism of human CYP2E1: characterization of two variant alleles. (PubMed id 9058590)1, 2, 9 Hu Y.... Ingelman-Sundberg M. (Mol. Pharmacol. 1997)
    18. NAT2 and CYP2E1 polymorphisms and susceptibility to first-line anti-tuberculosis drug-induced hepatitis. (PubMed id 20392357)1, 4, 9 Lee S.W....Wu L.S. (Int. J. Tuberc. Lung Dis. 2010)
    19. A novel polymorphism rs1329149 of CYP2E1 and a known polymorphism rs671 of ALDH2 of alcohol metabolizing enzymes are associated with colorectal cancer in a southwestern Chinese population. (PubMed id 19706845)1, 4, 9 Yang H....Cao J. (amp 2009)
    20. Genetic polymorphisms of CYP2E1 and risk of colorectal cancer: the Fukuoka Colorectal Cancer Study. (PubMed id 19124503)1, 4, 9 Morita M....Imaizumi N. (amp 2009)
    21. Genetic variations of NAT2 and CYP2E1 and isoniazid hepatotoxicity in a diverse population. (PubMed id 19761367)1, 4, 9 Yamada S....Marra F. (Pharmacogenomics 2009)
    22. [Relationship between susceptibility of formaldehyde metabolism and genetic polymorphisms of ALDH2 and cytochrome P4502E1]. (PubMed id 19115622)1, 4, 9 Cheng X.M....Shao H. (Zhonghua Yu Fang Yi Xue Za Zhi 2008)
    23. The effect of genetic polymorphisms in the vinyl chloride metabolic pathway on mutagenic risk. (PubMed id 17384900)1, 4, 9 Schindler J....Brandt-Rauf P.W. (J. Hum. Genet. 2007)
    24. Effect of the CYP2E1 genotype on vinyl chloride monomer-induced liver fibrosis among polyvinyl chloride workers. (PubMed id 17659824)1, 4, 9 Hsieh H.I....Cheng T.J. (Toxicology 2007)
    25. Effects of dietary intake and genetic factors on hypermethylation of the hMLH1 gene promoter in gastric cancer. (PubMed id 15991278)1, 4, 9 Nan H.M....Kim H. (World J. Gastroenterol. 2005)
    26. GSTT1, GSTM1 and CYP2E1 genetic polymorphisms in gastric cancer and chronic gastritis in a Brazilian population. (PubMed id 15112335)1, 4, 9 Colombo J....Silva A.E. (World J. Gastroenterol. 2004)
    27. Effects of genetic polymorphisms in metabolic enzymes on the relationships between 8-hydroxydeoxyguanosine levels in human leukocytes and urinary 1-hydroxypyrene and 2-naphthol concentrations. (PubMed id 14646291)1, 4, 9 Kim Y.D....Kim H. (J Occup Health 2003)
    28. Association of genetic polymorphisms in CYP2E1, MPO, NQO1, GSTM1, and GSTT1 genes with benzene poisoning. (PubMed id 12460800)1, 4, 9 Wan J....Hu G. (Environ. Health Perspect. 2002)
    29. Study of polymorphisms in the CYP2E1 gene in patients with alcoholic pancreatitis. (PubMed id 11331106)1, 4, 9 Yang B....Kingsnorth A.N. (Alcohol 2001)
    30. Association between CYP2E1 genetic polymorphisms and lung cancer risk: a meta-analysis. (PubMed id 20031389)1, 4, 9 Wang Y....Zhu B. (Eur. J. Cancer 2010)
    31. Association of polymorphism in alcohol dehydrogenase and interaction with other genetic risk factors with alcoholic liver cirrhosis. (PubMed id 20171022)1, 4, 9 Khan A.J....Parmar D. (Drug Alcohol Depend 2010)
    32. [Abnormal liver function associated with polymorphism of GSTT1, GSTM1 and CYP2E1 in workers exposed to N, N-dimethylformamide]. (PubMed id 19927646)1, 4, 9 Xu C.M....Zhang X. (Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2009)
    33. CYP1A2*1C, CYP2E1*5B, and GSTM1 polymorphisms are predictors of risk and poor outcome in head and neck squamous cell carcinoma patients. (PubMed id 19442564)1, 4, 9 Olivieri E.H....Rogatto S.R. (Oral Oncol. 2009)
    34. [Correlation of prostate cancer susceptibility with genetic polymorphism of cytochrome P450 2E1, smoking and drinking: a case-control study in the population of Nanjing area]. (PubMed id 19288740)1, 4, 9 Yang J....Wu H.F. (Zhonghua Nan Ke Xue 2009)
    35. Alcohol-metabolizing enzyme gene polymorphisms and alcohol chronic pancreatitis among Polish individuals. (PubMed id 18773092)1, 4, 9 Cichoz-Lach H....SA8omka M. (HPB (Oxford) 2008)
    36. Genetic polymorphisms of carcinogen metabolizing enzymes are associated with oral leukoplakia development and p53 overexpression. (PubMed id 18507060)1, 4, 9 Duarte E.C....Gomez R.S. (Anticancer Res. 2008)
    37. Drug-metabolising enzyme polymorphisms and predisposition to anti-tuberculosis drug-induced liver injury: a meta-analysis. (PubMed id 18713495)1, 4, 9 Sun F....Zhan S. (Int. J. Tuberc. Lung Dis. 2008)
    38. Association of combined CYP2E1 gene polymorphism with the risk for esophageal squamous cell carcinoma in Huai'an population, China. (PubMed id 18028774)1, 4, 9 Liu R....Pu Y.P. (Chin. Med. J. 2007)
    39. CYP2E1 genotype and isoniazid-induced hepatotoxicity in patients treated for latent tuberculosis. (PubMed id 16770646)1, 4, 9 Vuilleumier N....Hochstrasser D. (Eur. J. Clin. Pharmacol. 2006)
    40. Polymorphisms of metabolic enzyme genes, living habits and prostate cancer susceptibility. (PubMed id 16720291)1, 4, 9 Yang J....Qian L.X. (Front. Biosci. 2006)
    41. Role of epoxide hydrolase, NAD(P)H:quinone oxidoreductase, cytochrome P450 2E1 or alcohol dehydrogenase genotypes in susceptibility to colorectal cancer. (PubMed id 16039674)1, 4, 9 van der Logt E.M....Peters W.H. (Mutat. Res. 2006)
    42. The impact of genetic factors on the incidence of multiple primary tumors (MPT) of the head and neck. (PubMed id 15914277)1, 4, 9 Rydzanicz M....Szyfter K. (Cancer Lett. 2005)
    43. Genetic polymorphisms in the cytochromes P-450 (1A1, 2E1), microsomal epoxide hydrolase and glutathione S-transferase M1, T1, and P1 genes, and their relationship with chronic bronchitis and relapsing pneumonia in children. (PubMed id 15928955)1, 4, 9 Korytina G.F....Victorova T.V. (J. Mol. Med. 2005)
    44. Genetic polymorphisms of CYP2E1 and GSTP1 in a South Indian population--comparison with North Indians, Caucasians and Chinese. (PubMed id 16235992)1, 4, 9 Soya S.S....Adithan C. (Asian Pac. J. Cancer Prev. 2005)
    45. CYP1A1, CYP2D6, CYP2E1, NAT2, GSTM1 and GSTT1 polymorphisms or their combinations are associated with the increased risk of the laryngeal squamous cell carcinoma. (PubMed id 15914211)1, 4, 9 Gajecka M....Szyfter K. (Mutat. Res. 2005)
    46. Genetic polymorphisms and susceptibility to childhood acute lymphoblastic leukemia. (PubMed id 14991750)1, 4, 9 Canalle R....Takahashi C.S. (Environ. Mol. Mutagen. 2004)
    47. Genetic polymorphisms in alcohol-metabolizing enzymes and chronic pancreatitis. (PubMed id 14691069)1, 4, 9 Verlaan M....Drenth J.P. (Alcohol Alcohol. 2004)
    48. [Genetic polymorphism in cytochrome P450 2E1, salted food and colorectal cancer susceptibility: a case-control study]. (PubMed id 15182482)1, 4, 9 Yu W.P....Zhou H.G. (Zhonghua Yu Fang Yi Xue Za Zhi 2004)
    49. Occupational exposure to styrene: modulation of cytogenetic damage and levels of urinary metabolites of styrene by polymorphisms in genes CYP2E1, EPHX1, GSTM1, GSTT1 and GSTP1. (PubMed id 14751678)1, 4, 9 Teixeira J.P....Rueff J. (Toxicology 2004)
    50. Genetic polymorphism of the CYP1A1, CYP2E1, GSTM1 and GSTT1 genes and lung cancer susceptibility in a north indian population. (PubMed id 15646021)1, 4, 9 Sobti R.C....Janmeja A. (Mol. Cell. Biochem. 2004)
    51. Role of alcohol and genetic polymorphisms of CYP2E1 and ALDH2 in breast cancer development. (PubMed id 12563175)1, 4, 9 Choi J.Y....Kang D. (Pharmacogenetics 2003)
    52. Association of GSTM1, CYP1A1 and CYP2E1 genetic polymorphisms with susceptibility to lung adenocarcinoma: a case-control study in Chinese population. (PubMed id 12824892)1, 4, 9 Wang J....Tokudome S. (Cancer Sci. 2003)
    53. [Effects of genetic polymorphisms of ethanol-metabolizing enzymes on alcohol drinking behaviors]. (PubMed id 12824748)1, 4, 9 Kee J.Y....Chae H.B. (Taehan Kan Hakhoe Chi 2003)
    54. Genetic polymorphisms and susceptibility to esophageal cancer among Chinese population (review). (PubMed id 12883749)1, 4, 9 Xing D....Lin D. (Oncol. Rep. 2003)
    55. Polymorphisms for vinyl chloride metabolism in French vinyl chloride workers. (PubMed id 12705718)1, 4, 9 Li Y....Brandt-Rauf P.W. (Int J Occup Med Environ Health 2003)
    56. Genetic polymorphism of the CYP2E1 gene and susceptibility to Parkinson's disease in Taiwanese. (PubMed id 12454736)1, 4, 9 Wu R.M....Chern H.D. (J Neural Transm 2002)
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    447. Diverse action of acrylamide on cytochrome P450 and glutathione S-transferase isozyme activities, mRNA levels and protein levels in human hepatocarcinoma cells. (PubMed id 22392284)1 Sen A....Arslan S. (Cell Biol. Toxicol. 2012)
    448. Dalfampridine: a medication to improve walking in patients with multiple sclerosis. (PubMed id 22764324)7 Pikoulas T.E. and Fuller M.A. (Ann Pharmacother 2012)
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    450. Genetic polymorphisms of ADH1C and CYP2E1 and risk of oral squamous cell carcinoma. (PubMed id 21705789)1 Brocic M....Magic Z. (Otolaryngol Head Neck Surg 2011)
    451. DNA repair gene polymorphism is associated with the genetic basis of atherosclerotic coronary artery disease. (PubMed id 20093049)1 Bazo A.P....Salvadori D.M. (Cardiovasc. Pathol. 2011)
    452. Reversible inhibition of four important human liver cytochrome P450 enzymes by diethylstilbestrol. (PubMed id 21553654)7 Qu Y.Q....Wang L.M. (Pharmazie 2011)
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    454. Role of CYP2E1 genotypes in susceptibility to colorectal cancer in the Kashmiri population. (PubMed id 22155602)1 Sameer A.S....Siddiqi M.A. (Hum. Genomics 2011)
    455. Genetic polymorphisms of NAT2, CYP2E1 and GST enzymes and the occurrence of antituberculosis drug-induced hepatitis in Brazilian TB patients. (PubMed id 22012226)1 Teixeira R.L....Santos A.R. (Mem. Inst. Oswaldo Cruz 2011)
    456. Ethanol-mediated carcinogenesis in the human esophagus implicates CYP2E1 induction and the generation of carcinogenic DNA-lesions. (PubMed id 20715111)1 Millonig G....Seitz H.K. (Int. J. Cancer 2011)
    457. CYP1A2*1F and GSTM1 alleles are associated with susceptibility to porphyria cutanea tarda. (PubMed id 20957336)1 Wickliffe J.K....Anderson K.E. (Mol. Med. 2011)
    458. Genetic polymorphisms of the CYP2E1 gene do not contribute to oral cancer susceptibility in south Indians. (PubMed id 22126492)1 Balaji L....Bhaskar L.V. (Asian Pac. J. Cancer Prev. 2011)
    459. Relationship between CYP2E1 polymorphism and increase of ALT activity during therapy of patients with pulmonary tuberculosis. (PubMed id 22485222)1 Kudryashov A.V....Lyakhovich V.V. (Bull. Exp. Biol. Med. 2011)
    460. A negative cooperativity mechanism of human CYP2E1 inferred from molecular dynamics simulations and free energy calculations. (PubMed id 22077825)1 Li J....Li Y.X. (J Chem Inf Model 2011)
    461. The impact of CYP2E1 genetic variability on risk assessment of VOC mixtures. (PubMed id 21295098)1 Pohl H.R. and Scinicariello F. (Regul. Toxicol. Pharmacol. 2011)
    462. Meta-analyses of the effect of cytochrome P450 2E1 gene polymorphism on the risk of head and neck cancer. (PubMed id 21076874)1 Lu D....Du Y. (Mol. Biol. Rep. 2011)
    463. Role of polymorphic N-acetyl transferase2 and cytochrome P4502E1 gene in antituberculosis treatment-induced hepatitis. (PubMed id 21261721)1 Bose P.D....Kar P. (J. Gastroenterol. Hepatol. 2011)
    464. Identification of a cytochrome P4502E1/Bid/C1q-dependent axis mediating inflammation in adipose tissue after chronic ethanol feeding to mice. (PubMed id 21856753)1 Sebastian B.M....Nagy L.E. (J. Biol. Chem. 2011)
    465. Ubiquitin-dependent proteasomal degradation of human liver cytochrome P450 2E1: identification of sites targeted for phosphorylation and ubiquitination. (PubMed id 21209460)1 Wang Y....Correia M.A. (J. Biol. Chem. 2011)
    466. CYP2E1 Rsa I/Pst I polymorphism and esophageal cancer risk: a meta-analysis based on 1,088 cases and 2,238 controls. (PubMed id 20195803)1 Niu Y....Chen N. (Med. Oncol. 2011)
    467. APOE and CYP2E1 polymorphisms, alcohol consumption, and Parkinson's disease in a Japanese population. (PubMed id 21360299)1 Kiyohara C....Nagai M. (J Neural Transm 2011)
    468. NAT2, CYP2C9, CYP2C19, and CYP2E1 genetic polymorphisms in anti-TB drug-induced maculopapular eruption. (PubMed id 20941486)1 Kim S.H....Jee Y.K. (Eur. J. Clin. Pharmacol. 2011)
    469. The investigation into CYP2E1 in relation to the level of response to alcohol through a combination of linkage and association analysis. (PubMed id 20958328)1 Webb A....Wilhelmsen K. (Alcohol. Clin. Exp. Res. 2011)
    470. CYP1A1, CYP2E1, and GSTM1 gene polymorphisms and susceptibility to colorectal and gastric cancer among Lebanese. (PubMed id 21385088)1 Darazy M....Abdel-Razzak Z. (Genet Test Mol Biomarkers 2011)
    471. Depletion of cytosolic or mitochondrial thioredoxin increases CYP2E1-induced oxidative stress via an ASK-1-JNK1 pathway in HepG2 cells. (PubMed id 21557999)1 Yang L....Cederbaum A.I. (amp 2011)
    472. Single-nucleotide polymorphisms and haplotype of CYP2E1 gene associated with systemic lupus erythematosus in Chinese population. (PubMed id 21281483)1 Liao L.H....Shen N. (amp 2011)
    473. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    474. Localization of cytochrome P4502E1 enzyme in normal and cancerous gastric mucosa and association with its genetic polymorphism in unoperated and remnant stomach. (PubMed id 21869556)1 Kato S....Uchida E. (J Nippon Med Sch 2011)
    475. Human cytochrome P450 2E1 structures with fatty acid analogs reveal a previously unobserved binding mode. (PubMed id 20463018)1 Porubsky P.R....Scott E.E. (J. Biol. Chem. 2010)
    476. CYP2E1 enhances ethanol-induced lipid accumulation but impairs autophagy in HepG2 E47 cells. (PubMed id 20932821)1 Wu D....Cederbaum A. (Biochem. Biophys. Res. Commun. 2010)
    477. Breaking self-tolerance toward cytochrome P4502E1 (CYP2E1) in chronic hepatitis C: possible role for molecular mimicry. (PubMed id 20576306)1 Sutti S....Albano E. (J. Hepatol. 2010)
    478. Evaluation of candidate genes for cholinesterase activity in farmworkers exposed to organophosphorus pesticides: association of single nucleotide polymorphisms in BCHE. (PubMed id 20529763)1 Howard T.D....Arcury T.A. (Environ. Health Perspect. 2010)
    479. Metabolic stability and determination of cytochrome P450 isoenzymes' contribution to the metabolism of medetomidine in dog liver microsomes. (PubMed id 20020418)7 Duhamel M.C....Beaudry F. (Biomed. Chromatogr. 2010)
    480. Chronic alcohol-induced liver injury and oxidant stress are decreased in cytochrome P4502E1 knockout mice and restored in humanized cytochrome P4502E1 knock-in mice. (PubMed id 20692331)1 Lu Y....Cederbaum A.I. (amp 2010)
    481. Polymorphisms in GSTT1, GSTZ1, and CYP2E1, disinfection by-products, and risk of bladder cancer in Spain. (PubMed id 20675267)1 Cantor K.P....Kogevinas M. (Environ. Health Perspect. 2010)
    482. Single-nucleotide polymorphisms, acute rejection, and severity of tubulitis in kidney transplantation, accounting for center-to-center variation. (PubMed id 21085059)4 Israni A....Oetting W.S. (Transplantation 2010)
    483. Distribution of ADH1B, ALDH2, CYP2E1 *6, and CYP2E1 *7B genotypes in Turkish population. (PubMed id 20598484)1 KayaaltA+ Z. and SAPylemezoA9lu T. (Alcohol 2010)
    484. Genetic polymorphism analysis of cytochrome P4502E1 (CYP2E1) in Chinese Han populations from four different geographic areas of Mainland China. (PubMed id 20100563)1 Tang K....Qin S. (Genomics 2010)
    485. SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. (PubMed id 19934256)7 Preissner S....Preissner R. (Nucleic Acids Res. 2010)
    486. Genetic Polymorphisms of CYP2E1, GSTP1, NQO1 and MPO and the Risk of Nasopharyngeal Carcinoma in a Han Chinese Population of Southern China. (PubMed id 20663217)1 Guo X....O'Brien S.J. (BMC Res Notes 2010)
    487. Use of the CYP2E1 genotype and phenotype for the biological monitoring of occupational exposure to styrene. (PubMed id 20117323)1 Prieto-CastellA^ M.J....Corno A. (Toxicol. Lett. 2010)
    488. Flavopiridol pharmacogenetics: clinical and functional evidence for the role of SLCO1B1/OATP1B1 in flavopiridol disposition. (PubMed id 21072184)1 Ni W....Phelps M.A. (PLoS ONE 2010)
    489. [Genetic susceptibility of DNA damage induced by vinyl chloride monomer exposure]. (PubMed id 20426969)1 Ji F....Xia Z.L. (Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2010)
    490. Genetic variation in metabolizing enzyme and transporter genes: comprehensive assessment in 3 major East Asian subpopulations with comparison to Caucasians and Africans. (PubMed id 20173083)1 Man M....Hockett R. (J Clin Pharmacol 2010)
    491. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (Am. J. Hum. Genet. 2009)
    492. Frequencies of genotypes and alleles of the functional SNPs in CYP2C19 and CYP2E1 in mainland Chinese Kazakh, Uygur and Han populations. (PubMed id 19444287)4 Wang S.M....Zhang G.L. (J. Hum. Genet. 2009)
    493. Polymorphic drug metabolism in anaesthesia. (PubMed id 19442086)7 Restrepo J.G....AgA_ndez J.A. (Curr. Drug Metab. 2009)
    494. Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. (PubMed id 19515014)7 Zhou S.F....Cai J.P. (Curr. Med. Chem. 2009)
    495. Novel hierarchical classification and visualization method for multiobjective optimization of drug properties: application to structure-activity relationship analysis of cytochrome P450 metabolism. (PubMed id 18211048)1 Yamashita F....Hashida M. (J Chem Inf Model 2008)
    496. Pharmacokinetics/genotype associations for major cytochrome P450 enzymes in native and first- and third-generation Japanese populations: comparison with Korean, Chinese, and Caucasian populations. (PubMed id 18231117)1 Myrand S.P....Wilner K.D. (Clin. Pharmacol. Ther. 2008)
    497. Identification of the human cytochrome P450 enzymes involved in the in vitro biotransformation of lynestrenol and norethindrone. (PubMed id 18356043)1 Korhonen T....Pelkonen O. (J. Steroid Biochem. Mol. Biol. 2008)
    498. Lysophosphatidylserine-induced functional switch of human cytochrome P450 1A2 and 2E1 from monooxygenase to phospholipase D. (PubMed id 18801337)1 Cho E.Y....Ahn T. (Biochem. Biophys. Res. Commun. 2008)
    499. An NH2-terminal truncated cytochrome P450 CYP3A4 showing catalytic activity is present in the cytoplasm of human liver cells. (PubMed id 18446064)1 Jeon S....Lee A.Y. (amp 2008)
    500. Differences in hepatic cytochrome P450 activity correlate with the strain-specific biotransformation of medetomidine in AX/JU and IIIVO/JU inbred rabbits. (PubMed id 18638298)7 Avsaroglu H....Fink-Gremmels J. (J. Vet. Pharmacol. Ther. 2008)
    501. Development and properties of HepG2 cells that constitutively express CYP2E1. (PubMed id 18369917)1 Wu D. and Cederbaum A.I. (Methods Mol. Biol. 2008)
    502. Human CYP2E1 mediates the formation of glycidamide from acrylamide. (PubMed id 18418580)1 Settels E....Appel K.E. (Arch. Toxicol. 2008)
    503. CYP2E1 substrate inhibition. Mechanistic interpretation through an effector site for monocyclic compounds. (PubMed id 18056994)1 Collom S.L....Miller G.P. (J. Biol. Chem. 2008)
    504. Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study. (PubMed id 17903301)4 Vasan R.S....Benjamin E.J. (BMC Med. Genet. 2007)
    505. A comparison of substrate dynamics in human CYP2E1 and CYP2A6. (PubMed id 17156750)1 Harrelson J.P....Nelson S.D. (Biochem. Biophys. Res. Commun. 2007)
    506. The absence of interaction between drug metabolizing enzyme genotypes and maternal lifestyle factors on glycophorin A somatic mutation frequency levels in newborns. (PubMed id 16424825)1 Nukui T....Romkes M. (Pharmacogenet. Genomics 2006)
    507. Radical intermediates in the catalytic oxidation of hydrocarbons by bacterial and human cytochrome P450 enzymes. (PubMed id 16401082)1 Jiang Y....Ortiz de Montellano P.R. (Biochemistry 2006)
    508. Serum deprivation-induced HepG2 cell death is potentiated by CYP2E1. (PubMed id 16337880)1 Zhuge J. and Cederbaum A.I. (amp 2006)
    509. Transcription factor Nrf2 protects HepG2 cells against CYP2E1 plus arachidonic acid-dependent toxicity. (PubMed id 16551616)1 Gong P. and Cederbaum A.I. (J. Biol. Chem. 2006)
    510. Hepatogenic differentiation of human mesenchymal stem cells from adipose tissue in comparison with bone marrow mesenchymal stem cells. (PubMed id 17007050)1 TalAcns-Visconti R....GA^mez-LechA^n M.J. (World J. Gastroenterol. 2006)
    511. Rapid conformational dynamics of cytochrome P450 2E1 in a natural biological membrane environment. (PubMed id 17176083)1 Smith S.V....Friedman F.K. (Biochemistry 2006)
    512. Fast CYP2E1 genotyping using automated fluorescent detection. (PubMed id 17219769)1 Innocenti C....Violante F.S. (Med Lav 2006)
    513. Human cytochrome p450 induction and inhibition potential of clevidipine and its primary metabolite h152/81. (PubMed id 16501008)7 Zhang J.G....Wong J. (Drug Metab. Dispos. 2006)
    514. Identification of the interactions between cytochrome P450 2E1 and cytochrome b5 by mass spectrometry and site-directed mutagenesis. (PubMed id 16679316)1 Gao Q....Nelson S.D. (J. Biol. Chem. 2006)
    515. CYP2E1 induced by ethanol causes oxidative stress, proteasome inhibition and cytokeratin aggresome (Mallory body-like) formation. (PubMed id 17034788)1 Bardag-Gorce F....French S.W. (Exp. Mol. Pathol. 2006)
    516. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1 Grupe A....Goate A. (Am. J. Hum. Genet. 2006)
    517. Hepatocyte CYP2E1 overexpression and steatohepatitis lead to impaired hepatic insulin signaling. (PubMed id 15632182)1 Schattenberg J.M....Czaja M.J. (J. Biol. Chem. 2005)
    518. Genetic polymorphisms influencing xenobiotic metabolism and transport in patients with primary biliary cirrhosis. (PubMed id 15690482)4 Kimura Y....Gershwin M.E. (Hepatology 2005)
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    520. CYP2C9 gene variants, drug dose, and bleeding risk in warfarin-treated patients: a HuGEnet systematic review and meta-analysis. (PubMed id 15714076)1 Sanderson S....Higgins J. (Genet. Med. 2005)
    521. DLPC attenuates alcohol-induced cytotoxicity in HepG2 cells expressing CYP2E1. (PubMed id 15753073)1 Xu Y....Lieber C.S. (Alcohol Alcohol. 2005)
    522. Cytochrome P450 gene polymorphisms and risk of low birth weight. (PubMed id 15712341)1 Chen D....Wang L. (Genet. Epidemiol. 2005)
    523. Pharmacokinetics, pharmacodynamics and drug interaction potential of enfuvirtide. (PubMed id 15656696)7 Patel I.H....Buss N. (Clin Pharmacokinet 2005)
    524. Effect of insulin-mimetic vanadyl sulfate on cytochrome P450 2E1-dependent p-nitrophenol hydroxylation in the liver microsomes of streptozotocin-induced type 1 diabetic rats. (PubMed id 15964029)7 Kataoka S....Sakurai H. (Life Sci. 2005)
    525. Interactions of mammalian cytochrome P450, NADPH-cytochrome P450 reductase, and cytochrome b(5) enzymes. (PubMed id 15680923)1 Shimada T....Guengerich F.P. (Arch. Biochem. Biophys. 2005)
    526. Cytochrome P450 CYP2E1, but not nicotinamide adenine dinucleotide phosphate oxidase, is required for ethanol-induced oxidative DNA damage in rodent liver. (PubMed id 15660387)1 Bradford B.U....Rusyn I. (Hepatology 2005)
    527. Monitoring low benzene exposure: comparative evaluation of urinary biomarkers, influence of cigarette smoking, and genetic polymorphisms. (PubMed id 16172237)1 Fustinoni S....Merlo D.F. (amp 2005)
    528. Molecular chaperone, HSP60, and cytochrome P450 2E1 co-expression in dilated cardiomyopathy. (PubMed id 15763499)1 Sidorik L....Chaschin N.A. (Cell Biol. Int. 2005)
    529. Use of duplex PCR-CTPP methods for CYP2E1RsaI/IL-2 T-330G and IL-1B C-31T/TNF-A T-1031C polymorphisms. (PubMed id 16137184)1 Atsuta Y....Tamakoshi A. (Mol. Diagn. 2005)
    530. Intragraft iNOS induction during human liver allograft rejection depresses cytochrome p450 activity. (PubMed id 15349722)1 Westerholt A....Heidecke C.D. (Transpl. Int. 2004)
    531. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    532. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)2 Deloukas P.... Rogers J. (Nature 2004)
    533. Genetic polymorphisms of ADH2, ADH3, CYP4502E1 Dra-I and Pst-I, and ALDH2 in Spanish men: lack of association with alcoholism and alcoholic liver disease. (PubMed id 15519646)1 Vidal F....Richart C. (J. Hepatol. 2004)
    534. Quantitative contribution of CYP2D6 and CYP3A to oxycodone metabolism in human liver and intestinal microsomes. (PubMed id 15039299)1 Lalovic B....Shen D.D. (Drug Metab. Dispos. 2004)
    535. Increased prooxidant production and enhanced susceptibility to glutathione depletion in HepG2 cells co-expressing HCV core protein and CYP2E1. (PubMed id 14695664)1 Wen F....Schmidt W.N. (J. Med. Virol. 2004)
    536. Safrole-DNA adducts in human peripheral blood--an association with areca quid chewing and CYP2E1 polymorphisms. (PubMed id 15066574)1 Liu T.Y....Hsieh L.L. (Mutat. Res. 2004)
    537. The metabolic rate constants and specific activity of human and rat hepatic cytochrome P-450 2E1 toward toluene and chloroform. (PubMed id 15129551)7 Lipscomb J.C....Laskey J. (J. Toxicol. Environ. Health Part A 2004)
    538. Expression of cytochrome P4502E1 gene in hepatocellular carcinoma. (PubMed id 15162526)1 Man X.B....Wang H.Y. (World J. Gastroenterol. 2004)
    539. Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants. (PubMed id 15128046)1 Nelson D.R....Nebert D.W. (Pharmacogenetics 2004)
    540. Role of p38 MAPK in CYP2E1-dependent arachidonic acid toxicity. (PubMed id 12403788)1 Wu D. and Cederbaum A.I. (J. Biol. Chem. 2003)
    541. Increased expression of cytochrome P450 2E1 induces heme oxygenase-1 through ERK MAPK pathway. (PubMed id 12777398)1 Gong P....Nieto N. (J. Biol. Chem. 2003)
    542. Identification of the human liver enzymes involved in the metabolism of the antimigraine agent almotriptan. (PubMed id 12642466)7 Salva M....Palacios J.M. (Drug Metab. Dispos. 2003)
    543. CYP2E1: biochemistry, toxicology, regulation and function in ethanol-induced liver injury. (PubMed id 14527082)1 Kessova I. and Cederbaum A.I. (Curr. Mol. Med. 2003)
    544. Catalog of 680 variations among eight cytochrome p450 (CYP) genes, nine esterase genes, and two other genes in the Japanese population. (PubMed id 12721789)1 Saito S....Nakamura Y. (J. Hum. Genet. 2003)
    545. Role of phospholipase A2 activation and calcium in CYP2E1-dependent toxicity in HepG2 cells. (PubMed id 12813050)1 Caro A.A. and Cederbaum A.I. (J. Biol. Chem. 2003)
    546. Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport. (PubMed id 14499622)1 Reuter T.Y....Huber P.A. (Exp. Cell Res. 2003)
    547. Proteasome inhibition potentiates CYP2E1-mediated toxicity in HepG2 cells. (PubMed id 12774019)1 PAcrez M.J. and Cederbaum A.I. (Hepatology 2003)
    548. Cytochrome p450 and glutathione transferase expression in human breast cancer. (PubMed id 12738724)1 El-Rayes B.F....Philip P.A. (Clin. Cancer Res. 2003)
    549. Identification of sequences responsible for intracellular targeting and membrane binding of rat CYP2E1 in yeast. (PubMed id 14661969)1 Neve E.P....Ingelman-Sundberg M. (Biochemistry 2003)
    550. CYP2E1 overexpression up-regulates both non-specific delta-aminolevulinate synthase and heme oxygenase-1 in the human hepatoma cell line HLE/2E1. (PubMed id 12469218)1 Takahashi S....Sassa S. (Int. J. Mol. Med. 2003)
    551. Transcriptional activity of the tandem repeat polymorphism in the 5'-flanking region of the human CYP2E1 gene. (PubMed id 12960506)1 Nomura F....Ochiai T. (Alcohol. Clin. Exp. Res. 2003)
    552. Genetic susceptibility--molecular epidemiology of head and neck cancer. (PubMed id 11981277)4 Sturgis E.M. and Wei Q. (Curr Opin Oncol 2002)
    553. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
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    555. Possible impact of human CYP2E1 polymorphisms on the metabolism of acrylonitrile. (PubMed id 11869835)1 Thier R....Bolt H.M. (Toxicol. Lett. 2002)
    556. Low-penetrance genes and their involvement in colorectal cancer susceptibility. (PubMed id 12433710)4 de Jong M.M....Kleibeuker J.H. (amp 2002)
    557. Cytochrome P450 2E1-derived reactive oxygen species mediate paracrine stimulation of collagen I protein synthesis by hepatic stellate cells. (PubMed id 11782477)1 Nieto N....Cederbaum A.I. (J. Biol. Chem. 2002)
    558. Genetic polymorphisms and lung cancer susceptibility: a review. (PubMed id 12234692)4 Kiyohara C....Hopkin J.M. (Lung Cancer 2002)
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    562. Does the polymorphism of cytochrome P-450 2E1 affect the metabolism of N,N-dimethylformamide? Comparison of the half-lives of urinary N-methylformamide. (PubMed id 11305777)1 Nomiyama T....Omae K. (Arch. Toxicol. 2001)
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    707. Characterisation of xenobiotic-metabolising enzyme expression in human bronchial mucosa and peripheral lung tissues. (PubMed id 9797707)9 MacAc K....Pfeifer A.M. (Eur. J. Cancer 1998)
    708. Induction of CYP2E1 activity in liver transplant patients as measured by chlorzoxazone 6-hydroxylation. (PubMed id 9542473)9 Burckart G.J....Venkataramanan R. (Clin. Pharmacol. Ther. 1998)
    709. Effect of CYP3A inhibition on vesnarinone metabolism in humans. (PubMed id 9630823)9 Wandel C....Wood A.J. (Clin. Pharmacol. Ther. 1998)
    710. Ethanol-related cytotoxicity catalyzed by CYP2E1-dependent generation of reactive oxygen intermediates in transduced HepG2 cells. (PubMed id 9699015)9 Cederbaum A.I. (Biofactors 1998)
    711. P-450-dependent metabolism of lauric acid in alcoholic liver disease: comparison between rat liver and kidney microsomes. (PubMed id 9581653)9 Amet Y....French S.W. (Alcohol. Clin. Exp. Res. 1998)
    712. [Genetic polymorphisms of cytochrome P450 2E1 and glutathione S-transferase P1 and susceptibility to esophageal cancer]. (PubMed id 10920953)9 Lin D....Peng Q. (Zhonghua Zhong Liu Za Zhi 1998)
    713. Oxidation of 1,3-butadiene to (R)- and (S)-butadiene monoxide by purified recombinant cytochrome P450 2E1 from rabbit, rat and human. (PubMed id 9635416)9 Nieusma J.L....Ross D. (Toxicol. Lett. 1998)
    714. Cytochrome P450-dependent metabolism of trichloroethylene: interindividual differences in humans. (PubMed id 9070354)9 Lipscomb J.C....Snawder J.E. (Toxicol. Appl. Pharmacol. 1997)
    715. Absence of a differential induction of cytochrome P450 2E1 by different alcoholic beverages in rats: implications for the aetiology of human oesophageal cancer. (PubMed id 9363842)9 Lechevrel M. and Wild C.P. (Arch. Toxicol. 1997)
    716. Genotypes of alcohol-metabolizing enzymes and the risk for alcoholic chronic pancreatitis in Japanese alcoholics. (PubMed id 8986224)9 Matsumoto M....Ishii H. (Alcohol. Clin. Exp. Res. 1996)
    717. Human cytochrome P450 2E1 is a major autoantigen associated with halothane hepatitis. (PubMed id 8902272)9 Bourdi M....Pohl L.R. (Chem. Res. Toxicol. 1996)
    718. Human lung carcinogen-DNA adduct levels mediated by genetic polymorphisms in vivo. (PubMed id 7666479)9 Kato S....Shields P.G. (J. Natl. Cancer Inst. 1995)
    719. Regiospecific expression of cytochrome P-450s and microsomal epoxide hydrolase in human brain tissue. (PubMed id 7693960)9 Farin F.M. and Omiecinski C.J. (J Toxicol Environ Health 1993)
    720. Metabolic cytochrome P450 genotypes and assessment of individual susceptibility to lung cancer. (PubMed id 1306126)9 Hirvonen A....Vainio H. (Pharmacogenetics 1992)
    721. Bariatric surgery-induced weight loss reduces hepatic lipid peroxidation levels and affects hepatic cytochrome P-450 protein content. (PubMed id 20485142)9 Bell L.N....Mattar S.G. (Ann. Surg. 2010)
    722. Ethanol enhances hepatitis C virus replication through lipid metabolism and elevated NADH/NAD+. (PubMed id 19910460)9 Seronello S....Choi J. (J. Biol. Chem. 2010)
    723. Interaction of antitumor platinum complexes with human liver microsomal cytochromes P450. (PubMed id 19378397)9 Masek V....Anzenbacher P. (Anticancer Drugs 2009)
    724. NQO1, MPO, CYP2E1, GSTT1 and GSTM1 polymorphisms and biological effects of benzene exposure--a literature review. (PubMed id 18848868)9 Dougherty D....Taioli E. (Toxicol. Lett. 2008)
    725. Pharmacogenomics of anti-TB drugs-related hepatotoxicity. (PubMed id 18303967)9 Roy P.D....Roy B. (Pharmacogenomics 2008)
    726. Acetaldehyde generating enzyme systems: roles of alcohol dehydrogenase, CYP2E1 and catalase, and speculations on the role of other enzymes and processes. (PubMed id 17590984)9 Crabb D.W. and Liangpunsakul S. (Novartis Found. Symp. 2007)
    727. Re-evaluation of fatty acid metabolism-related gene expression in nonalcoholic fatty liver disease. (PubMed id 17671740)9 Kohjima M....Nakamuta M. (Int. J. Mol. Med. 2007)
    728. Role of microsomal enzymes in development of alcoholic liver diseases. (PubMed id 17567472)9 Konishi M. and Ishii H. (J. Gastroenterol. Hepatol. 2007)
    729. Inhibition of human liver cytochrome P450 by star fruit juice. (PubMed id 18261370)9 Zhang J.W....Yang L. (amp 2007)
    730. Expression of cytochrome P450 and MDR1 in patients with proctitis. (PubMed id 18484072)9 ThAPrn M....LAPAPf L. (Ups. J. Med. Sci. 2007)
    731. Ethanol oxidation into acetaldehyde by 16 recombinant human cytochrome P450 isoforms: role of CYP2C isoforms in human liver microsomes. (PubMed id 17084997)9 Hamitouche S....Lucas D. (Toxicol. Lett. 2006)
    732. Role of CYP2D6, CYP1A1, CYP2E1, GSTT1, and GSTM1 genes in the susceptibility to acute leukemias. (PubMed id 16493615)9 Aydin-Sayitoglu M....Ozbek U. (Am. J. Hematol. 2006)
    733. Potential impact of steatosis on cytochrome P450 enzymes of human hepatocytes isolated from fatty liver grafts. (PubMed id 16763015)9 Donato M.T....GA^mez-LechA^n M.J. (Drug Metab. Dispos. 2006)
    734. Effect of natural analogues of trans-resveratrol on cytochromes P4501A2 and 2E1 catalytic activities. (PubMed id 16684708)9 Mikstacka R....Baer-Dubowska W. ( the fate of foreign compounds in biological systems 2006)
    735. Individual susceptibility and alcohol effects:biochemical and genetic aspects. (PubMed id 16801720)9 Gemma S....Testai E. (Ann. Ist. Super. Sanita 2006)
    736. Porcine cytochrome P450 and metabolism. (PubMed id 16611125)9 Skaanild M.T. (Curr. Pharm. Des. 2006)
    737. Role of CYP2E1 activity in endoplasmic reticulum ubiquitination, proteasome association, and the unfolded protein response. (PubMed id 15797236)9 Lewis M.D. and Roberts B.J. (Arch. Biochem. Biophys. 2005)
    738. Cytochromes P450 and MDR1 mRNA expression along the human gastrointestinal tract. (PubMed id 15963094)9 ThAPrn M....LAPAPf L. (Br J Clin Pharmacol 2005)
    739. Decreased expression of cytochrome P450 protein in non-malignant colonic tissue of patients with colonic adenoma. (PubMed id 16281975)9 Bergheim I....Parlesak A. (BMC Gastroenterol 2005)
    740. Tissue-distribution of aldehyde dehydrogenase 2 and effects of the ALDH2 gene-disruption on the expression of enzymes involved in alcohol metabolism. (PubMed id 15569633)9 Oyama T....Kawamoto T. (Front. Biosci. 2005)
    741. Kimchi and soybean pastes are risk factors of gastric cancer. (PubMed id 15929164)9 Nan H.M....Kim H. (World J. Gastroenterol. 2005)
    742. Ethanol metabolism alters interferon gamma signaling in recombinant HepG2 cells. (PubMed id 16250053)9 Osna N.A....Donohue T.M. (Hepatology 2005)
    743. [Feasibility of genetic polymorphisms analysis using genomic DNA obtained from human buccal cells]. (PubMed id 16004823)9 Cheng J.R....Gao Y.T. (Ai Zheng 2005)
    744. Oxidative stress-related parameters in the liver of non-alcoholic fatty liver disease patients. (PubMed id 14556645)9 Videla L.A....Poniachik J. (Clin. Sci. 2004)
    745. Inhibitory effects of memantine on human cytochrome P450 activities: prediction of in vivo drug interactions. (PubMed id 15378224)9 Micuda S....Martinkova J. (Eur. J. Clin. Pharmacol. 2004)
    746. Alcoholic fatty liver: its pathogenesis and mechanism of progression to inflammation and fibrosis. (PubMed id 15670660)9 Lieber C.S. (Alcohol 2004)
    747. Impact of warm ischemic time on microsomal P450 isoforms in a porcine model of therapeutic liver resection. (PubMed id 15501478)9 Suzuki S....Kobayashi E. (Life Sci. 2004)
    748. [Cloning and sequence analysis of human embryonic nasopharyngeal epithelial CYP2E1 cDNA]. (PubMed id 12934348)9 Hou D.F....Yang F. (Hunan Yi Ke Da Xue Xue Bao 2003)
    749. Iron and CYP2E1-dependent oxidative stress and toxicity. (PubMed id 12957295)9 Cederbaum A.I. (Alcohol 2003)
    750. Study of the fragmentation mechanism of protonated 6-hydroxychlorzoxazone: application in simultaneous analysis of CYP2E1 activity with major human cytochrome P450s. (PubMed id 12585472)9 Anari M.R....Baillie T.A. (Anal. Chem. 2003)
    751. Interest of genotyping and phenotyping of drug-metabolizing enzymes for the interpretation of biological monitoring of exposure to styrene. (PubMed id 12464798)9 Haufroid V....Lison D. (Pharmacogenetics 2002)
    752. Roles of NADPH-P450 reductase and apo- and holo-cytochrome b5 on xenobiotic oxidations catalyzed by 12 recombinant human cytochrome P450s expressed in membranes of Escherichia coli. (PubMed id 11922748)9 Yamazaki H....Yokoi T. (Protein Expr. Purif. 2002)
    753. Fluoride excretion in children after sevoflurane anaesthesia. (PubMed id 12393764)9 Lejus C....Pinaud M. (Br J Anaesth 2002)
    754. [Evidence based prevention (EBP): evidence-based approach to prevention of lung cancer by application of cytochrome 2E1 polymorphism]. (PubMed id 12506858)9 Oyama T....Yasumoto K. (J. UOEH 2002)
    755. Effects of the ADH3, CYP2E1, and GSTP1 genetic polymorphisms on their expressions in Caucasian lung tissue. (PubMed id 12367788)9 Yang M....Kadlubar F.F. (Lung Cancer 2002)
    756. CYP2E1-mediated modulation of valproic acid-induced hepatocytotoxicity. (PubMed id 11408019)9 Neuman M.G....Abbott F. (Clin. Biochem. 2001)
    757. Role of human cytochrome P450 (CYP) in the metabolic activation of N-alkylnitrosamines: application of genetically engineered Salmonella typhimurium YG7108 expressing each form of CYP together with human NADPH-cytochrome P450 reductase. (PubMed id 11600130)9 Fujita K. and Kamataki T. (Mutat. Res. 2001)
    758. Selective dehydrogenation/oxygenation of 3-methylindole by cytochrome p450 enzymes. (PubMed id 11408359)9 Lanza D.L. and Yost G.S. (Drug Metab. Dispos. 2001)
    759. Independent patterns of cytochrome P450 gene expression in liver and blood in patients with suspected liver disease. (PubMed id 11599658)9 FinnstrAPm N....Rane A. (Eur. J. Clin. Pharmacol. 2001)
    760. Polymorphism of the 5'-flanking region of the CYP2E1 gene: an association study with alcoholism. (PubMed id 11410734)9 Itoga S....Nomura F. (Alcohol. Clin. Exp. Res. 2001)
    761. Effects of occupation, lifestyle and genetic polymorphisms of CYP1A1, CYP2E1, GSTM1 and GSTT1 on urinary 1-hydroxypyrene and 2-naphthol concentrations. (PubMed id 11323399)9 Nan H.M....Kwon E.H. (Carcinogenesis 2001)
    762. In vitro inhibition of human P450 enzymes by prenylated flavonoids from hops, Humulus lupulus. (PubMed id 10752639)9 Henderson M.C....Buhler D.R. ( the fate of foreign compounds in biological systems 2000)
    763. Influence of genetic susceptibility on the urinary excretion of 8-hydroxydeoxyguanosine of firefighters. (PubMed id 10810125)9 Hong Y.C....Ha E.H. (Occup Environ Med 2000)
    764. Adaptation to chronic ethanol administration emphasized by fatty acid hydroxylations in rat liver and kidney microsomes. (PubMed id 11395987)9 Amet Y....French S.W. (Eur J Nutr 2000)
    765. The effects of the ALDH2*1/2, CYP2E1 C1/C2 and C/D genotypes on blood ethanol elimination. (PubMed id 10826103)9 Yoshihara E....Iwahashi K. (Drug Chem Toxicol 2000)
    766. Fingerprinting of cytochrome P450 and microsomal epoxide hydrolase gene expression in human blood cells. (PubMed id 10828267)9 Krovat B.C....Omiecinski C.J. (Toxicol. Sci. 2000)
    767. Induction of cytochrome P450 (CYP)1A1, CYP1A2, and CYP3A4 but not of CYP2C9, CYP2C19, multidrug resistance (MDR-1) and multidrug resistance associated protein (MRP-1) by prototypical inducers in human hepatocytes. (PubMed id 10873607)9 Runge D....Michalopoulos G.K. (Biochem. Biophys. Res. Commun. 2000)
    768. Association of genetic polymorphisms of alcohol-metabolizing enzymes with excessive alcohol consumption in Japanese men. (PubMed id 10543395)9 Sun F....Yamada Y. (Hum. Genet. 1999)
    769. Hydroxyethyl radicals in ethanol hepatotoxicity. (PubMed id 10369806)9 Albano E....Ingelman-Sundberg M. (Front. Biosci. 1999)
    770. Protective effect of chlormethiazole, a sedative, against acetaminophen-induced liver injury in mice. (PubMed id 10461422)9 Lee H.C....Park S.S. (Korean J. Intern. Med. 1999)
    771. CYP2E1-mediated oxidative stress induces collagen type I expression in rat hepatic stellate cells. (PubMed id 10498651)9 Nieto N....Cederbaum A.I. (Hepatology 1999)
    772. Prevalence of disease-related DNA polymorphisms among participants in a large cancer prevention trial. (PubMed id 10548400)9 Woodson K....Albanes D. (Eur. J. Cancer Prev. 1999)
    773. Clinical isoflurane metabolism by cytochrome P450 2E1. (PubMed id 10078678)9 Kharasch E.D....Cox K. (Anesthesiology 1999)
    774. Role of the cellular redox state in modulating acute ethanol toxicity in isolated hepatocytes. (PubMed id 10614722)9 Khan S. and O'Brien P.J. (Clin. Biochem. 1999)
    775. Susceptibility to esophageal cancer and genetic polymorphisms in glutathione S-transferases T1, P1, and M1 and cytochrome P450 2E1. (PubMed id 9829710)9 Lin D.X....Kadlubar F.F. (amp 1998)
    776. Quantification of multiple human cytochrome P450 mRNA molecules using competitive reverse transcriptase-PCR. (PubMed id 9539103)9 Andersen M.R....Omiecinski C.J. (DNA Cell Biol. 1998)
    777. Identification of the human P-450 enzymes responsible for the sulfoxidation and thiono-oxidation of diethyldithiocarbamate methyl ester: role of P-450 enzymes in disulfiram bioactivation. (PubMed id 9756035)9 Madan A....Faiman M.D. (Alcohol. Clin. Exp. Res. 1998)
    778. Role of human liver P450s and cytochrome b5 in the reductive metabolism of 3'-azido-3'-deoxythymidine (AZT) to 3'-amino-3'-deoxythymidine. (PubMed id 9586947)9 Pan-Zhou X.R....Sommadossi J.P. (Biochem. Pharmacol. 1998)
    779. Clinical and toxicological consequences of the inductive potential of ethanol. (PubMed id 9591923)9 Klotz U. and Ammon E. (Eur. J. Clin. Pharmacol. 1998)
    780. Measurement of cytochrome P450 2A6 and 2E1 gene expression in primary human bronchial epithelial cells. (PubMed id 9806171)9 Crawford E.L....Willey J.C. (Carcinogenesis 1998)
    781. p53 mutation spectrum in relation to GSTM1, CYP1A1 and CYP2E1 in surgically treated patients with non-small cell lung cancer. (PubMed id 9918134)9 Przygodzki R.M....Caporaso N.E. (Pharmacogenetics 1998)
    782. Genetic polymorphism of CYP2E1, ADH2, and ALDH2 in Mexican-Americans. (PubMed id 10464602)9 Wan Y.J....Lin K.M. (Genet. Test. 1998)
    783. Inhibition of CYP2E1 by chlormethiazole as measured by chlorzoxazone pharmacokinetics in patients with alcoholism and in healthy volunteers. (PubMed id 9695719)9 Eap C.B....Buclin T. (Clin. Pharmacol. Ther. 1998)
    784. Time-dependent expression of cytochrome P450 genes in primary cultures of well-differentiated human hepatocytes. (PubMed id 9178731)9 George J....Farrell G.C. (J. Lab. Clin. Med. 1997)
    785. Cytochrome P450 2E1 polymorphism as a risk factor for lung cancer: in relation to p53 gene mutation. (PubMed id 9066584)9 Oyama T....Yasumoto K. (Anticancer Res. 1997)
    786. Genetic polymorphisms of tobacco- and alcohol-related metabolizing enzymes and human esophageal squamous cell carcinoma susceptibility. (PubMed id 9451664)9 Hori H....Yuasa Y. (J. Clin. Gastroenterol. 1997)
    787. Identification of the cytochrome P450 isoforms involved in the O-demethylation of 4-nitroanisole in human liver microsomes. (PubMed id 9364740)9 Jones B.C....Smith D.A. ( the fate of foreign compounds in biological systems 1997)
    788. CYP1A1, CYP2E1 and GSTM1 polymorphisms are not associated with susceptibility to squamous-cell carcinoma of the esophagus. (PubMed id 9139841)9 Morita S....Monden M. (Int. J. Cancer 1997)
    789. Interactions between genetic predisposition and environmental toxicants for development of lung cancer. (PubMed id 9329644)9 el-Zein R....Au W.W. (Environ. Mol. Mutagen. 1997)
    790. Biotransformation of chlorzoxazone by hepatic microsomes from humans and ten other mammalian species. (PubMed id 9113344)9 Court M.H....Greenblatt D.J. (amp 1997)
    791. Acetaminophen metabolism and cytotoxicity in PC12 cells transfected with cytochrome P4502E1. (PubMed id 9253715)9 Holownia A....Braszko J.J. (J. Mol. Med. 1997)
    792. Protection of ethanol-mediated acetaminophen hepatotoxicity by triacetyloleandomycin, a specific inhibitor of CYP3A. (PubMed id 8997458)9 Kostrubsky V.E....Sinclair J.F. (Ann. Clin. Lab. Sci. 1997)
    793. Characterization of inducible nitric-oxide synthase by cytochrome P-450 substrates and inhibitors. Inhibition by chlorzoxazone. (PubMed id 8995391)9 Grant S.K....Kozarich J.W. (J. Biol. Chem. 1997)
    794. Genetic polymorphisms of CYP2E1, GSTM1, and GSTT1; environmental factors and risk of oral cancer. (PubMed id 9367063)9 Hung H.C....Chen C.J. (amp 1997)
    795. Genetic polymorphism of GSTM1, CYP2E1 and CYP2D6 in Egyptian bladder cancer patients. (PubMed id 8824515)9 Anwar W.A....Au W.W. (Carcinogenesis 1996)
    796. Genetic polymorphisms of the cancer related gene and Helicobacter pylori infection in Japanese gastric cancer patients. An age and gender matched case-control study. (PubMed id 8608558)9 Kato S....Shields P.G. (Cancer 1996)
    797. Fluoroquinolone antibiotics inhibit cytochrome P450-mediated microsomal drug metabolism in rat and human. (PubMed id 8894516)9 McLellan R.A....Renton K.W. (Drug Metab. Dispos. 1996)
    798. Inter-individual variability in the oxidation of 1,2-dibromoethane: use of heterologously expressed human cytochrome P450 and human liver microsomes. (PubMed id 8870687)9 Wormhoudt L.W....Vermeulen N.P. (Chem. Biol. Interact. 1996)
    799. Influence of clinicopathological variables on CYP protein expression in human liver. (PubMed id 8672739)9 George J....Farrell G.C. (J. Gastroenterol. Hepatol. 1996)
    800. Metabolism of 1,2-dichloro-1-fluoroethane and 1-fluoro-1,2,2-trichloroethane: electronic factors govern the regioselectivity of cytochrome P450-dependent oxidation. (PubMed id 8924616)9 Yin H....Jones J.P. (Chem. Res. Toxicol. 1996)
    801. Ethanol and isopentanol increase CYP3A and CYP2E in primary cultures of human hepatocytes. (PubMed id 7574728)9 Kostrubsky V.E....Sinclair J.F. (Arch. Biochem. Biophys. 1995)
    802. Genetic polymorphism of cytochromes P450 1A1, 2D6 and 2E1: regulation and toxicological significance. (PubMed id 7620940)9 Rannug A....Ingelman-Sundberg M. (J. Occup. Environ. Med. 1995)
    803. Selective serotonin reuptake inhibitors and theophylline metabolism in human liver microsomes: potent inhibition by fluvoxamine. (PubMed id 7742153)9 Rasmussen B.B....sen K. (Br J Clin Pharmacol 1995)
    804. Effects of ALDH2, CYP1A1, and CYP2E1 genetic polymorphisms and smoking and drinking habits on toluene metabolism in humans. (PubMed id 7645026)9 Kawamoto T....Kodama Y. (Toxicol. Appl. Pharmacol. 1995)
    805. Ethanol increases cytochrome P4502E1 and induces oxidative stress in astrocytes. (PubMed id 7595552)9 Montoliu C....Guerri C. (J. Neurochem. 1995)
    806. Activation of alkylhydrazines to free radical intermediates by ethanol-inducible cytochrome P-4502E1 (CYP2E1). (PubMed id 7727516)9 Albano E....Ingelman-Sundberg M. (Biochim. Biophys. Acta 1995)
    807. Lauric acid as a model substrate for the simultaneous determination of cytochrome P450 2E1 and 4A in hepatic microsomes. (PubMed id 7696540)9 Clarke S.E....Chenery R.J. (Chem. Res. Toxicol. 1994)
    808. Hepatoprotective mechanism of silymarin: no evidence for involvement of cytochrome P450 2E1. (PubMed id 8194125)9 Miguez M.P....Lindros K.O. (Chem. Biol. Interact. 1994)
    809. [Relationship between alcoholism and genotypes of acetaldehyde-metabolizing enzymes]. (PubMed id 8135667)9 Iwahashi K....Orino K. (amp 1994)
    810. Assessment of cytochrome P4502E1 induction in alcoholic patients by chlorzoxazone pharmacokinetics. (PubMed id 7910460)9 Girre C....Menez J.F. (Biochem. Pharmacol. 1994)
    811. The human CYP2E1 gene and lung cancer: DraI and RsaI restriction fragment length polymorphisms in a Finnish study population. (PubMed id 8093864)9 Hirvonen A....Vainio H. (Carcinogenesis 1993)
    812. Aetiology and pathogenesis of alcoholic liver disease. (PubMed id 8219401)9 Lieber C.S. (Baillieres Clin. Gastroenterol. 1993)
    813. Both cytochromes P450 2E1 and 1A1 are involved in the metabolism of chlorzoxazone. (PubMed id 7509644)9 Carriere V....Berthou F. (Chem. Res. Toxicol. 1993)
    814. Cytokines down-regulate expression of major cytochrome P-450 enzymes in adult human hepatocytes in primary culture. (PubMed id 8232220)9 Abdel-Razzak Z....Guillouzo A. (Mol. Pharmacol. 1993)
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    817. Role of alcohol metabolism in non-alcoholic steatohepatitis. (PubMed id 20221393)9 Baker S.S....Zhu L. (PLoS ONE 2010)
    818. Relationships between metabolic and non-metabolic susceptibility factors in benzene toxicity. (PubMed id 19941840)9 Ross D. and Zhou H. (Chem. Biol. Interact. 2010)
    819. Evaluation of two different metabolic hypotheses for dichloromethane toxicity using physiologically based pharmacokinetic modeling for in vivo inhalation gas uptake data exposure in female B6C3F1 mice. (PubMed id 20153349)9 Evans M.V. and Caldwell J.C. (Toxicol. Appl. Pharmacol. 2010)
    820. Time-dependent inhibition (TDI) of CYP3A4 and CYP2C9 by noscapine potentially explains clinical noscapine-warfarin interaction. (PubMed id 20233183)9 Fang Z.Z....Yang L. (Br J Clin Pharmacol 2010)
    821. Evaluation of antioxidant parameters in rats treated with sevoflurane. (PubMed id 20485961)9 Bezerra F.J....Almeida M.d. (Rev Bras Anestesiol 2010)
    822. Alcohol influence on acrylamide to glycidamide metabolism assessed with hemoglobin-adducts and questionnaire data. (PubMed id 20034532)9 VikstrAPm A.C....TAPrnqvist M. (Food Chem. Toxicol. 2010)
    823. Peripheral blood effects in benzene-exposed workers. (PubMed id 20034484)9 Robert Schnatter A....Irons R.D. (Chem. Biol. Interact. 2010)
    824. 2,3,7,8-Tetrachlorodibenzo-p-dioxin and beta-naphthoflavone induce cellular hypertrophy in H9c2 cells by an aryl hydrocarbon receptor-dependant mechanism. (PubMed id 19969063)9 Zordoky B.N. and El-Kadi A.O. (Toxicol In Vitro 2010)
    825. Evidence of oxidative stress and associated DNA damage, increased proliferative drive, and altered gene expression in rat liver produced by the cholangiocarcinogenic agent furan. (PubMed id 20124500)9 Hickling K.C....Chipman J.K. (Toxicol Pathol 2010)
    826. The influence of genetic polymorphisms on population variability in six xenobiotic-metabolizing enzymes. (PubMed id 20183525)9 Ginsberg G....Sonawane B. (J Toxicol Environ Health B Crit Rev 2009)
    827. Air pollution particulate matter (PM2.5)-induced gene expression of volatile organic compound and/or polycyclic aromatic hydrocarbon-metabolizing enzymes in an in vitro coculture lung model. (PubMed id 18952161)9 Abbas I....GarAson G. (Toxicol In Vitro 2009)
    828. Effect of acetylcholinesterase oxime-type reactivators K-48 and HI-6 on human liver microsomal cytochromes P450 in vitro. (PubMed id 19539805)9 Veinlichova A....Anzenbacherova E. (Chem. Biol. Interact. 2009)
    829. Immunohistochemical studies on early stage of hepatic damage induced by subacute inhalation of toluene vapor in rats. (PubMed id 19391120)9 Gotohda T....Morita K. (J Appl Toxicol 2009)
    830. Synergic effects of alpha-tocopherol and beta-carotene on tert-butylhydroperoxide-induced HepG2 cell injury. (PubMed id 19651802)9 Park S....Lee M. (Toxicol Ind Health 2009)
    831. Role of NF-kappaB in the regulation of cytochrome P450 enzymes. (PubMed id 19275551)9 Zordoky B.N. and El-Kadi A.O. (Curr. Drug Metab. 2009)
    832. Overexpression of liver-specific cytochrome P4502E1 impairs hepatic insulin signaling in a transgenic mouse model of nonalcoholic fatty liver disease. (PubMed id 19307976)9 Kathirvel E....Morgan T.R. (amp 2009)
    833. Chronic oxidative stress sensitizes hepatocytes to death from 4-hydroxynonenal by JNK/c-Jun overactivation. (PubMed id 20501438)9 Singh R....Czaja M.J. (Am. J. Physiol. Gastrointest. Liver Physiol. 2009)
    834. Serum autoantibodies against cytochrome P450 2E1 (CYP2E1) predict severity of necroinflammation of recurrent hepatitis C. (PubMed id 19191768)9 Rigamonti C....Albano E. (Am. J. Transplant. 2009)
    835. Does CYP2E1 play a major role in the aggravation of isoniazid toxicity by rifampicin in human hepatocytes? (PubMed id 19371336)9 Yue J. and Peng R. (Br. J. Pharmacol. 2009)
    836. A predominate role of CYP1A2 for the metabolism of nabumetone to the active metabolite, 6-methoxy-2-naphthylacetic acid, in human liver microsomes. (PubMed id 19204080)9 Turpeinen M....Zanger U.M. (Drug Metab. Dispos. 2009)
    837. Relationship between oxidative stress and hepatic glutathione levels in ethanol-mediated apoptosis of polarized hepatic cells. (PubMed id 19496190)9 McVicker B.L....Tuma D.J. (World J. Gastroenterol. 2009)
    838. Sevoflurane: its action on heme metabolism and Phase I drug metabolizing system. (PubMed id 19656462)9 Sampayo R....Buzaleh A.M. (Cell. Mol. Biol. (Noisy-le-grand) 2009)
    839. Using acetaminophen's toxicity mechanism to enhance cisplatin efficacy in hepatocarcinoma and hepatoblastoma cell lines. (PubMed id 19794959)9 Neuwelt A.J....Wozniak M. (Neoplasia 2009)
    840. Coordinate regulation of metabolic enzymes and transporters by nuclear transcription factors in human liver disease. (PubMed id 19638083)9 Congiu M....Desmond P.V. (J. Gastroenterol. Hepatol. 2009)
    841. [Genetic base of esophageal squamous cell carcinoma susceptibility]. (PubMed id 19388510)9 SzumiA8o J....Burdan F. (Pol. Merkur. Lekarski 2009)
    842. Pharmacogenomics in drug induced liver injury. (PubMed id 20214588)9 Andrade R.J....GarcA-a-MartA-n E. (Curr. Drug Metab. 2009)
    843. Effect of polyphenolic compounds from Solanum torvum on plasma lipid peroxidation, superoxide anion and cytochrome P450 2E1 in human liver microsomes. (PubMed id 20041835)9 Kusirisin W....Narongchai P. (Med Chem 2009)
    844. Polyenephosphatidylcholine prevents alcoholic liver disease in PPARalpha-null mice through attenuation of increases in oxidative stress. (PubMed id 19398233)9 Okiyama W....Aoyama T. (J. Hepatol. 2009)
    845. Induction of hepatic aminolevulinate acid synthetase activity by isoflurane in a genetic model for erythropoietic protoporphyria. (PubMed id 19268000)9 Buzaleh A.M....Fontanellas A. (Cell. Mol. Biol. (Noisy-le-grand) 2009)
    846. Alcohol and genetic polymorphisms: effect on risk of alcohol-related cancer. (PubMed id 19185835)9 Druesne-Pecollo N....Latino-Martel P. (Lancet Oncol. 2009)
    847. The mibefradil derivative NNC55-0396, a specific T-type calcium channel antagonist, exhibits less CYP3A4 inhibition than mibefradil. (PubMed id 18411403)9 Bui P.H....Hankinson O. (Drug Metab. Dispos. 2008)
    848. Influence of diosmin pretreatment on the pharmacokinetics of chlorzoxazone in healthy male volunteers. (PubMed id 19326774)9 Rajnarayana K....Krishna D.R. (Drug Metabol Drug Interact 2008)
    849. Catecholamines induce an inflammatory response in human hepatocytes. (PubMed id 18431272)9 Aninat C....Guillouzo A. (Crit. Care Med. 2008)
    850. Pharmacokinetic parameters of chlorzoxazone and its main metabolite, 6-hydroxychlorzoxazone, after intravenous and oral administration of chlorzoxazone to liver cirrhotic rats with diabetes mellitus. (PubMed id 18378564)9 Ahn C.Y....Shin W.G. (Drug Metab. Dispos. 2008)
    851. Modulation of cardiac and hepatic cytochrome P450 enzymes during heart failure. (PubMed id 18288954)9 Zordoky B.N. and El-Kadi A.O. (Curr. Drug Metab. 2008)
    852. Evaluation of drug-drug interaction potential of beraprost sodium mediated by P450 in vitro. (PubMed id 18827466)9 Fukazawa T....Miyamoto Y. (Yakugaku Zasshi 2008)
    853. Mechanism of alcohol-induced oxidative stress and neuronal injury. (PubMed id 18845238)9 Haorah J....Persidsky Y. (amp 2008)
    854. Up-regulation of drug-metabolizing enzyme genes in layered co-culture of a human liver cell line and endothelial cells. (PubMed id 18847370)9 Ohno M....Taniguchi A. (Tissue Eng Part A 2008)
    855. Gender differences in pharmacological response. (PubMed id 18929073)9 Anderson G.D. (Int. Rev. Neurobiol. 2008)
    856. Pharmacology and metabolism of renzapride : a novel therapeutic agent for the potential treatment of irritable bowel syndrome. (PubMed id 18095752)9 Meyers N.L. and Hickling R.I. (amp 2008)
    857. Decreased expression of cytochromes P450 1A2, 2E1, and 3A4 and drug transporters Na+-taurocholate-cotransporting polypeptide, organic cation transporter 1, and organic anion-transporting peptide-C correlates with the progression of liver fibrosis in chronic hepatitis C patients. (PubMed id 18515332)9 Nakai K....Ohno Y. (Drug Metab. Dispos. 2008)
    858. Cytochrome P450 2B6 catalyzes the formation of pharmacologically active sibutramine (N-{1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutyl}-N,N-dimethylamine) metabolites in human liver microsomes. (PubMed id 18474675)9 Bae S.K....Shin J.G. (Drug Metab. Dispos. 2008)
    859. Changes of multiple biotransformation phase I and phase II enzyme activities in human fetal adrenals during fetal development. (PubMed id 18215353)9 Wang H....Hong J.Y. (Acta Pharmacol. Sin. 2008)
    860. [Genetic polymorphism for genes of alcohol dependence]. (PubMed id 18424410)9 He G.F....Jing Q. (Yi Chuan 2008)
    861. Lymphocyte cytochrome P450 expression: inducibility studies in male Wistar rats. (PubMed id 18476487)9 Hannon-Fletcher M.P. and Barnett Y.A. (Br. J. Biomed. Sci. 2008)
    862. Limited applicability of 7-methoxy-4-trifluoromethylcoumarin as a CYP2C9-selective substrate. (PubMed id 19211991)9 Porrogi P....Monostory K. (Pharmacol Rep 2008)
    863. Degradation of low molecular weight volatile organic compounds by plants genetically modified with mammalian cytochrome P450 2E1. (PubMed id 18350910)9 James C.A....Strand S.E. (amp 2008)
    864. Transcription factor and drug-metabolizing enzyme gene expression in lymphocytes from healthy human subjects. (PubMed id 17940135)9 Siest G....Visvikis-Siest S. (Drug Metab. Dispos. 2008)
    865. Confirmation that cytochrome P450 2C8 (CYP2C8) plays a minor role in (S)-(+)- and (R)-(-)-ibuprofen hydroxylation in vitro. (PubMed id 18787056)9 Chang S.Y....Rodrigues A.D. (Drug Metab. Dispos. 2008)
    866. Genotoxicity of glycidamide in comparison to 3-N-nitroso-oxazolidin-2-one. (PubMed id 18624445)9 Baum M....Eisenbrand G. (J. Agric. Food Chem. 2008)
    867. Functional expression and comparative characterization of nine murine cytochromes P450 by fluorescent inhibition screening. (PubMed id 18420780)9 McLaughlin L.A....Henderson C.J. (Drug Metab. Dispos. 2008)
    868. Alcohol and the liver. (PubMed id 18408461)9 Reuben A. (Curr. Opin. Gastroenterol. 2008)
    869. Hepatic cytochrome P450 2E1 activity in nonalcoholic fatty liver disease. (PubMed id 18672640)9 Prompila N....Komolmit P. (J Med Assoc Thai 2008)
    870. Utility of polyclonal antibodies targeted toward unique tryptic peptides in the proteomic analysis of cytochrome P450 isozymes. (PubMed id 18207356)9 Kornilayev B.A. and Alterman M.A. (Toxicol In Vitro 2008)
    871. Cytogenetic damage induced by acrylamide and glycidamide in mammalian cells: correlation with specific glycidamide-DNA adducts. (PubMed id 17088317)9 Martins C....Gaspar J.F. (Toxicol. Sci. 2007)
    872. Effect of recombinant human thymosin-alpha1, an immuno-modulating peptide with 28 amino acids, on the activity of cytochrome P450s. (PubMed id 19356044)9 Wang B....Zhou S.F. (Drug Metab Lett 2007)
    873. Increased cytochrome P450 and aryl hydrocarbon receptor in bronchial epithelium of heavy smokers with non-small cell lung carcinoma carries a poor prognosis. (PubMed id 17485391)9 Oyama T....Kawamoto T. (Front. Biosci. 2007)
    874. Characterization of human cytochrome p450 enzymes involved in the metabolism of cilostazol. (PubMed id 17646278)9 Hiratsuka M....Mizugaki M. (Drug Metab. Dispos. 2007)
    875. Role of the proteasome in ethanol-induced liver pathology. (PubMed id 17760783)9 Donohue T.M....Osna N.A. (Alcohol. Clin. Exp. Res. 2007)
    876. Effects of dexamethasone on mRNA abundance of nuclear receptors and hepatic nuclear receptor target genes in neonatal calves. (PubMed id 17217392)9 Greger D.L. and Blum J.W. (J Anim Physiol Anim Nutr (Berl) 2007)
    877. The 2006 Bernard B. Brodie Award Lecture. Cyp2e1. (PubMed id 17020953)9 Gonzalez F.J. (Drug Metab. Dispos. 2007)
    878. Genetic polymorphisms and esophageal cancer risk. (PubMed id 17674367)9 Hiyama T....Chayama K. (Int. J. Cancer 2007)
    879. Characterization of cynomolgus monkey cytochrome P450 (CYP) cDNAs: is CYP2C76 the only monkey-specific CYP gene responsible for species differences in drug metabolism? (PubMed id 17689485)9 Uno Y....Nagata R. (Arch. Biochem. Biophys. 2007)
    880. Determinants of alcohol use and abuse: Impact of quantity and frequency patterns on liver disease. (PubMed id 18046720)9 Zakhari S. and Li T.K. (Hepatology 2007)
    881. Role of MAPK phosphatase-1 in sustained activation of JNK during ethanol-induced apoptosis in hepatocyte-like VL-17A cells. (PubMed id 17848570)9 Venugopal S.K....Zern M.A. (J. Biol. Chem. 2007)
    882. Quantitative analysis of N-terminal valine peptide adducts specific for 1,2-epoxy-3-butene. (PubMed id 16860298)9 Georgieva N.I....Swenberg J.A. (Chem. Biol. Interact. 2007)
    883. Evaluation of genetic damage in Brazilian footwear-workers: biomarkers of exposure, effect, and susceptibility. (PubMed id 17292523)9 Heuser V.D....da Silva J. (Toxicology 2007)
    884. Polymorphism in nucleotide excision repair gene XPC correlates with bleomycin-induced chromosomal aberrations. (PubMed id 17685459)9 Laczmanska I....Sasiadek M.M. (Environ. Mol. Mutagen. 2007)
    885. Cytochrome P450 expression (CYP) in non-small cell lung cancer. (PubMed id 17127240)9 Oyama T....Yasumoto K. (Front. Biosci. 2007)
    886. Detection of auto-antibodies against cytochrome P4502E1 (CYP2E1) in chronic hepatitis C. (PubMed id 17196701)9 Vidali M....Albano E. (J. Hepatol. 2007)
    887. Effect of acetaminophen administration to rats chronically exposed to depleted uranium. (PubMed id 17126469)9 GuAcguen Y....Souidi M. (Toxicology 2007)
    888. Involvement of reactive oxygen species in Microcystin-LR-induced cytogenotoxicity. (PubMed id 17963120)9 Nong Q....Takeuchi T. (Free Radic. Res. 2007)
    889. S-adenosylmethionine attenuates oxidative liver injury in micropigs fed ethanol with a folate-deficient diet. (PubMed id 17850216)9 Villanueva J.A....Halsted C.H. (Alcohol. Clin. Exp. Res. 2007)
    890. Changes in the expression of cytochrome P450 genes in hemin-induced differentiated K562 cells. (PubMed id 17917270)9 Nagai F....Tamura H. (amp 2007)
    891. Lithium toxicity and expression of stress-related genes or proteins in A549 cells. (PubMed id 17512992)9 Allagui M.S....Croute F. (Biochim. Biophys. Acta 2007)
    892. Electrochemiluminescent arrays for cytochrome P450-activated genotoxicity screening. DNA damage from benzo[a]pyrene metabolites. (PubMed id 17261025)9 Hvastkovs E.G....Rusling J.F. (Anal. Chem. 2007)
    893. Cytochrome p450 and glutathione s-transferase mRNA expression in human fetal liver hematopoietic stem cells. (PubMed id 17050647)9 Shao J....Gallagher E.P. (Drug Metab. Dispos. 2007)
    894. Identification of covalent modifications in P450 2E1 by 1,2-epoxy-3-butene in vitro. (PubMed id 17298833)9 Boysen G....Swenberg J.A. (Chem. Biol. Interact. 2007)
    895. [Alcohol dehydrogenase and the metabolism of ethanol in the brain]. (PubMed id 18364675)9 Jelski W....Szmitkowski M. (Postepy Hig Med Dosw (Online) 2007)
    896. Common pathogenic mechanism in development progression of liver injury caused by non-alcoholic or alcoholic steatohepatitis. (PubMed id 18198478)9 Nagata K....Sakaguchi S. (J Toxicol Sci 2007)
    897. Effect of dietary epigallocatechin-3-gallate on cytochrome P450 2E1-dependent alcoholic liver damage: enhancement of fatty acid oxidation. (PubMed id 18071271)9 Yun J.W....Kim B.H. (Biosci. Biotechnol. Biochem. 2007)
    898. CYP2C9 protein interactions with cytochrome b(5): effects on the coupling of catalysis. (PubMed id 17446262)9 Locuson C.W....Tracy T.S. (Drug Metab. Dispos. 2007)
    899. An in vitro evaluation of cytochrome P450 inhibition and P-glycoprotein interaction with goldenseal, Ginkgo biloba, grape seed, milk thistle, and ginseng extracts and their constituents. (PubMed id 17611934)9 Etheridge A.S....Mathews J.M. (Planta Med. 2007)
    900. Hepatic expression of candidate genes in patients with alcoholic hepatitis: correlation with disease severity. (PubMed id 17258719)9 Colmenero J....GinA"s P. (Gastroenterology 2007)
    901. Determination of major human cytochrome P450s activities in 96-well plates using liquid chromatography tandem mass spectrometry. (PubMed id 17521862)9 Lahoz A....Castell J.V. (Toxicol In Vitro 2007)
    902. Exposure assessment of benzene in Thai workers, DNA-repair capacity and influence of genetic polymorphisms. (PubMed id 17095285)9 Chanvaivit S....Ruchirawat M. (Mutat. Res. 2007)
    903. Pharmacogenetic aspects of therapy with cholinesterase inhibitors: the role of CYP2D6 in Alzheimer's disease pharmacogenetics. (PubMed id 17908053)9 Cacabelos R....FernA!ndez-Novoa L. (Curr Alzheimer Res 2007)
    904. In vitro metabolism of indiplon and an assessment of its drug interaction potential. (PubMed id 17620220)9 Madan A....Bozigian H.P. ( the fate of foreign compounds in biological systems 2007)
    905. The garlic ingredient diallyl sulfide inhibits cytochrome P450 2E1 dependent bioactivation of acrylamide to glycidamide. (PubMed id 16337756)9 Taubert D....SchAPmig E. (Toxicol. Lett. 2006)
    906. Application of cryopreserved human hepatocytes in trichloroethylene risk assessment: relative disposition of chloral hydrate to trichloroacetate and trichloroethanol. (PubMed id 16882532)9 Bronley-DeLancey A....Hoel D.G. (Environ. Health Perspect. 2006)
    907. Hepatic and renal cytochrome p450 gene regulation during citrobacter rodentium infection in wild-type and toll-like receptor 4 mutant mice. (PubMed id 16339354)9 Richardson T.A....Morgan E.T. (Drug Metab. Dispos. 2006)
    908. Metabolism of the new anxiolytic agent, a pyrido[1,2-]benzimidazole (PBI) analog (RWJ-53050), in rat and human hepatic S9 fractions, and in dog; identification of cytochrome p450 isoforms mediated in the human microsomal metabolism. (PubMed id 17315539)9 Wu W.N....Reitz A.B. (Eur J Drug Metab Pharmacokinet 2006)
    909. Modulation of different stress pathways after styrene and styrene-7,8-oxide exposure in HepG2 cell line and normal human hepatocytes. (PubMed id 16705669)9 Diodovich C....Gribaldo L. (J Appl Toxicol 2006)
    910. Vitamins C and E protect hepatic cytochrome P450 dysfunction induced by polymicrobial sepsis. (PubMed id 16483564)9 Kim J.Y. and Lee S.M. (Eur. J. Pharmacol. 2006)
    911. A prospective study of isolated human hepatocyte function following liver resection for colorectal liver metastases: the effects of prior exposure to chemotherapy. (PubMed id 16635536)9 Hewes J.C....Fuller B. (J. Hepatol. 2006)
    912. Chlorzoxazone metabolism is increased in fasted Sprague-Dawley rats. (PubMed id 16393464)9 Wan J....Shoaf S.E. (J. Pharm. Pharmacol. 2006)
    913. Liver-specific loss of beta-catenin blocks glutamine synthesis pathway activity and cytochrome p450 expression in mice. (PubMed id 16557553)9 Sekine S....Hebrok M. (Hepatology 2006)
    914. Occupational toluene exposure induces cytochrome P450 2E1 mRNA expression in peripheral lymphocytes. (PubMed id 16581535)9 Mendoza-CantA_ A....Albores A. (Environ. Health Perspect. 2006)
    915. Catalytic assays for human cytochrome P450: an introduction. (PubMed id 16719375)9 Chang T.K. and Waxman D.J. (Methods Mol. Biol. 2006)
    916. Liver disease selectively modulates cytochrome P450--mediated metabolism. (PubMed id 16952490)9 Frye R.F....Branch R.A. (Clin. Pharmacol. Ther. 2006)
    917. A medicinal-chemistry-guided approach to selective and druglike sigma 1 ligands. (PubMed id 16892345)9 Corbera J....Holenz J. (ChemMedChem 2006)
    918. Etiological study of esophageal squamous cell carcinoma in an endemic region: a population-based case control study in Huaian, China. (PubMed id 17173682)9 Wang Z....Wang J.S. (BMC Cancer 2006)
    919. A mechanistic approach for the scaling of clearance in children. (PubMed id 16802850)9 Edginton A.N....Willmann S. (Clin Pharmacokinet 2006)
    920. Epoxidation of the methamphetamine pyrolysis product, trans-phenylpropene, to trans-phenylpropylene oxide by CYP enzymes and stereoselective glutathione adduct formation. (PubMed id 16038959)9 Sanga M....Callery P.S. (Toxicol. Appl. Pharmacol. 2006)
    921. High-fat emulsion-induced rat model of nonalcoholic steatohepatitis. (PubMed id 16624332)9 Zou Y....Wang Y. (Life Sci. 2006)
    922. 4-hydroxynonenal induces mitochondrial oxidative stress, apoptosis and expression of glutathione S-transferase A4-4 and cytochrome P450 2E1 in PC12 cells. (PubMed id 16843508)9 Raza H. and John A. (Toxicol. Appl. Pharmacol. 2006)
    923. Eszopiclone, a nonbenzodiazepine sedative-hypnotic agent for the treatment of transient and chronic insomnia. (PubMed id 16750462)9 Najib J. (Clin Ther 2006)
    924. Development of a transactivator in hepatoma cells that allows expression of phase I, phase II, and chemical defense genes. (PubMed id 16135546)9 Goldring C.E....Park B.K. (Am. J. Physiol., Cell Physiol. 2006)
    925. Expression of xenobiotic and steroid hormone metabolizing enzymes in human breast carcinomas. (PubMed id 16721811)9 Haas S....Fischer H.P. (Int. J. Cancer 2006)
    926. Effects of phlebotomy therapy on cytochrome P450 2e1 activity and oxidative stress markers in dysmetabolic iron overload syndrome: a randomized trial. (PubMed id 17014579)9 LainAc F....Deugnier Y. (amp 2006)
    927. Alcohol and cancer. (PubMed id 16455479)9 Boffetta P. and Hashibe M. (Lancet Oncol. 2006)
    928. Exposure to wood smoke, HPV infection, and genetic susceptibility for cervical neoplasia among women in Colombia. (PubMed id 16795085)9 Sierra-Torres C.H....Orejuela-Aristizabal L. (Environ. Mol. Mutagen. 2006)
    929. No association between polymorphisms in CYP2E1, GSTM1, NAT1, NAT2 and the risk of gastric adenocarcinoma in the European prospective investigation into cancer and nutrition. (PubMed id 16702391)9 Agudo A....GonzA!lez C.A. (amp 2006)
    930. Theoretical study of the mechanism of acetaldehyde hydroxylation by compound I of CYP2E1. (PubMed id 16553429)9 Wang Y....Han K. (J Phys Chem B 2006)
    931. Cytogenetic and molecular biomonitoring of a Portuguese population exposed to pesticides. (PubMed id 16980312)9 Costa C....Mayan O. (Mutagenesis 2006)
    932. Geldanamycin, an inhibitor of Hsp90, potentiates cytochrome P4502E1-mediated toxicity in HepG2 cells. (PubMed id 16513847)9 Dey A. and Cederbaum A.I. (J. Pharmacol. Exp. Ther. 2006)
    933. Progress of epidemiological and molecular epidemiological studies on benzene in China. (PubMed id 17119257)9 Li G. and Yin S. (Ann. N. Y. Acad. Sci. 2006)
    934. Overview: how is alcohol metabolized by the body? (PubMed id 17718403)9 Zakhari S. (amp 2006)
    935. Cyp2a6 is a principal enzyme involved in hydroxylation of 1,7-dimethylxanthine, a main caffeine metabolite, in humans. (PubMed id 15980104)9 Kimura M....Kamataki T. (Drug Metab. Dispos. 2005)
    936. Alcohol, vitamin A, and cancer. (PubMed id 16054987)9 Wang X.D. (Alcohol 2005)
    937. [Drug-drug interaction of antifungal drugs]. (PubMed id 16205037)9 Niwa T....Takagi A. (Yakugaku Zasshi 2005)
    938. Acetaminophen decreases intracellular glutathione levels and modulates cytokine production in human alveolar macrophages and type II pneumocytes in vitro. (PubMed id 15878691)9 Dimova S....Nemery B. (amp 2005)
    939. Sesamin ingestion regulates the transcription levels of hepatic metabolizing enzymes for alcohol and lipids in rats. (PubMed id 16344595)9 Kiso Y....Abe K. (Alcohol. Clin. Exp. Res. 2005)
    940. The stimulatory role of human cytochrome b5 in the bioactivation activities of human CYP1A2, 2A6 and 2E1: a new cell expression system to study cytochrome P450 mediated biotransformation. (PubMed id 15728263)9 Duarte M.P....Kranendonk M. (Mutagenesis 2005)
    941. Absence of acrylamide-induced genotoxicity in CYP2E1-null mice: evidence consistent with a glycidamide-mediated effect. (PubMed id 15982677)9 Ghanayem B.I....Recio L. (Mutat. Res. 2005)
    942. Expression of nuclear receptor and target genes in liver and intestine of neonatal calves fed colostrum and vitamin A. (PubMed id 16230703)9 KrA1ger K.A....Greger D.L. (J. Dairy Sci. 2005)
    943. In vitro metabolism of a new oxazolidinedione hypoglycemic agent utilizing liver microsomes and recombinant human cytochrome P450 enzymes. (PubMed id 15708677)9 Agrawal A.K....Franklin R.B. (J Pharm Biomed Anal 2005)
    944. Voglibose potentiates the hepatotoxicity of carbon tetrachloride and acetaminophen by inducing CYP2E1 in rats. (PubMed id 16162422)9 Qin L.Q....Sato A. (Hepatol. Res. 2005)
    945. Identification of cytochrome P450 forms involved in the 4-hydroxylation of valsartan, a potent and specific angiotensin II receptor antagonist, in human liver microsomes. (PubMed id 16192110)9 Nakashima A....Iwasaki K. ( the fate of foreign compounds in biological systems 2005)
    946. Liver grafts preserved in Celsior solution as source of hepatocytes for drug metabolism studies: comparison with surgical liver biopsies. (PubMed id 15448115)9 Donato M.T....GA^mez-LechA^n M.J. (Drug Metab. Dispos. 2005)
    947. Evaluation in vinyl chloride monomer-exposed workers and the relationship between liver lesions and gene polymorphisms of metabolic enzymes. (PubMed id 16270392)9 Zhu S.M....Xia Z.L. (World J. Gastroenterol. 2005)
    948. Metabolism and bioactivation of toxicants in the lung. The in vitro cellular approach. (PubMed id 16092727)9 Castell J.V....GA^mez-LechA^n M.J. (Exp. Toxicol. Pathol. 2005)
    949. Identification of human cytochrome P450 enzymes involved in the formation of 4-hydroxyestazolam from estazolam. (PubMed id 16012077)9 Miura M....Ohkubo T. ( the fate of foreign compounds in biological systems 2005)
    950. Biomarkers of benzene: urinary metabolites in relation to individual genotype and personal exposure. (PubMed id 15935803)9 Qu Q....Mu R. (Chem. Biol. Interact. 2005)
    951. Tobacco smoke-dependent changes in cytochrome P450 1A1, 1A2, and 2E1 protein expressions in fetuses, newborns, pregnant rats, and human placenta. (PubMed id 15448981)9 Czekaj P....Wiaderkiewicz R. (Arch. Toxicol. 2005)
    952. Modulation of hepatic and renal drug metabolizing enzyme activities in rats by subchronic administration of farnesol. (PubMed id 15840382)9 Horn T.L....McCormick D.L. (Chem. Biol. Interact. 2005)
    953. Green tea polyphenol epigallocatechin-3-gallate differentially modulates oxidative stress in PC12 cell compartments. (PubMed id 16129114)9 Raza H. and John A. (Toxicol. Appl. Pharmacol. 2005)
    954. Cytochrome P450 expression and activities in human tongue cells and their modulation by green tea extract. (PubMed id 15629189)9 Yang S.P. and Raner G.M. (Toxicol. Appl. Pharmacol. 2005)
    955. Alcohol consumption and cancer of the gastrointestinal tract. (PubMed id 16508294)9 Seitz H.K....Stickel F. (Dig Dis 2005)
    956. Zinc prevention and treatment of alcoholic liver disease. (PubMed id 16099027)9 Kang Y.J. and Zhou Z. (Mol. Aspects Med. 2005)
    957. Carcinogenic pollutants o-nitroanisole and o-anisidine are substrates and inducers of cytochromes P450. (PubMed id 16601807)9 RA1dlovA! H....StiborovA! M. (Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2005)
    958. The liver-selective nitric oxide donor O2-vinyl 1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate (V-PYRRO/NO) protects HepG2 cells against cytochrome P450 2E1-dependent toxicity. (PubMed id 14722244)9 Gong P....Nieto N. (Mol. Pharmacol. 2004)
    959. Markers of individual susceptibility and DNA repair rate in workers exposed to xenobiotics in a tire plant. (PubMed id 15470755)9 Vodicka P....Hemminki K. (Environ. Mol. Mutagen. 2004)
    960. [Expression of cytochrome P450 enzymes in human nasopharyngeal carcinoma and non-cancerous nasopharynx tissue]. (PubMed id 15191668)9 Jiang J.H....Zeng Y.X. (Ai Zheng 2004)
    961. Estimation of interindividual variation in oxidative metabolism of dichloromethane in human volunteers. (PubMed id 15501612)9 Sweeney L.M....Gargas M.L. (Toxicol. Lett. 2004)
    962. Validated assays for human cytochrome P450 activities. (PubMed id 15155557)9 Walsky R.L. and Obach R.S. (Drug Metab. Dispos. 2004)
    963. Cytochrome P450 gene polymorphism and cancer. (PubMed id 15180491)9 Agundez J.A. (Curr. Drug Metab. 2004)
    964. Gastrointestinal symptoms and ethanol metabolism in alcoholics. (PubMed id 15309892)9 Laheij R.J....Jansen J.B. (Dig. Dis. Sci. 2004)
    965. WIF-B cells as a model for alcohol-induced hepatocyte injury. (PubMed id 15135311)9 Schaffert C.S....Tuma D.J. (Biochem. Pharmacol. 2004)
    966. [Preliminary study on polymorphism of GSTM1, CYP2E1 and NQO1 genes and risk factors of children leukemia]. (PubMed id 15555372)9 Wu Y.X....Xia Z.L. (Zhonghua Liu Xing Bing Xue Za Zhi 2004)
    967. Establishment of ten strains of genetically engineered Salmonella typhimurium TA1538 each co-expressing a form of human cytochrome P450 with NADPH-cytochrome P450 reductase sensitive to various promutagens. (PubMed id 15279838)9 Yamazaki Y....Kamataki T. (Mutat. Res. 2004)
    968. Impact of inter-individual differences in drug metabolism and pharmacokinetics on safety evaluation. (PubMed id 15548231)9 Dorne J.L. (amp 2004)
    969. A convenient five-drug cocktail for the assessment of major drug metabolizing enzymes: a pilot study. (PubMed id 15327588)9 Sharma A....Hamelin B.A. (Br J Clin Pharmacol 2004)
    970. Gene expression of cytochromes P450 in liver transplants over time. (PubMed id 15197524)9 ThAPrn M....Rane A. (Eur. J. Clin. Pharmacol. 2004)
    971. Assessment of drug-drug interaction potential of enfuvirtide in human immunodeficiency virus type 1-infected patients. (PubMed id 15179410)9 Zhang X....Patel I.H. (Clin. Pharmacol. Ther. 2004)
    972. Influence of GSTT1, mEH, CYP2E1 and RAD51 polymorphisms on diepoxybutane-induced SCE frequency in cultured human lymphocytes. (PubMed id 15036125)9 Schlade-Bartusiak K....Sasiadek M. (Mutat. Res. 2004)
    973. Pharmacokinetic drug-drug interaction of the novel anticancer agent E7070 and acenocoumarol. (PubMed id 14739663)9 van den Bongard H.J....Schellens J.H. (Invest New Drugs 2004)
    974. NADPH dependent activation of microsomal glutathione transferase 1. (PubMed id 15013818)9 Rinaldi R....Morgenstern R. (Chem. Biol. Interact. 2004)
    975. Model of nonalcoholic steatohepatitis. (PubMed id 14985228)9 Lieber C.S....DeCarli L.M. (Am. J. Clin. Nutr. 2004)
    976. Alcohol and cancer: genetic and nutritional aspects. (PubMed id 15070439)9 PAPschl G....Seitz H.K. (Proc Nutr Soc 2004)
    977. Role of mouse CYP2E1 in the O-hydroxylation of p-nitrophenol: comparison of activities in hepatic microsomes from Cyp2e1(-/-) and wild-type mice. (PubMed id 15205381)9 Wolf K.K....Sinclair J.F. (Drug Metab. Dispos. 2004)
    978. Fluorescence-based assays for screening nine cytochrome P450 (P450) activities in intact cells expressing individual human P450 enzymes. (PubMed id 15205384)9 Donato M.T....GA^mez-LechA^n M.J. (Drug Metab. Dispos. 2004)
    979. Role of fatty liver, dietary fatty acid supplements, and obesity in the progression of alcoholic liver disease: introduction and summary of the symposium. (PubMed id 15670659)9 Purohit V....Coates P.M. (Alcohol 2004)
    980. Effects of chronic exposure to cadmium on renal cytochrome P450-dependent monooxygenase system in rats. (PubMed id 14595535)9 Plewka A....Moniuszko-Jakoniuk J. (Arch. Toxicol. 2004)
    981. Crystal structures of human cytochrome P450 3A4 bound to metyrapone and progesterone. (PubMed id 15256616)9 Williams P.A.... Jhoti H. (Science 2004)
    982. Interaction of dexloxiglumide, a cholecystokinin type-1 receptor antagonist, with human cytochromes P450. (PubMed id 15108219)9 Hall M....Rovati L.C. (amp 2004)
    983. Pharmacokinetic changes in drugs during protein-calorie malnutrition: correlation between drug metabolism and hepatic microsomal cytochrome P450 isozymes. (PubMed id 15356995)9 Lee J.H....Lee M.G. (Arch. Pharm. Res. 2004)
    984. New concepts of the pathogenesis of alcoholic liver disease lead to novel treatments. (PubMed id 14720455)9 Lieber C.S. (Curr Gastroenterol Rep 2004)
    985. Presence of cytochrome P450 enzymes in human CD34+ haematopoietic progenitor cells. (PubMed id 15696863)9 KousalovA! L....VondrakovA! J. (Gen. Physiol. Biophys. 2004)
    986. Effect of bupropion on CYP2B6 and CYP3A4 catalytic activity, immunoreactive protein and mRNA levels in primary human hepatocytes: comparison with rifampicin. (PubMed id 14604466)9 Hesse L.M....Greenblatt D.J. (J. Pharm. Pharmacol. 2003)
    987. Interferon gamma enhances proteasome activity in recombinant Hep G2 cells that express cytochrome P4502E1: modulation by ethanol. (PubMed id 12948850)9 Osna N.A....Donohue T.M. (Biochem. Pharmacol. 2003)
    988. Differential inhibition of human cytochrome P450 enzymes by epsilon-viniferin, the dimer of resveratrol: comparison with resveratrol and polyphenols from alcoholized beverages. (PubMed id 12818727)9 Piver B....Lucas D. (Life Sci. 2003)
    989. Rapid determination of enzyme activities of recombinant human cytochromes P450, human liver microsomes and hepatocytes. (PubMed id 14689466)9 Ghosal A....Zbaida S. (amp 2003)
    990. Role of alcohol metabolism in alcoholic pancreatitis. (PubMed id 14576493)9 Wilson J.S. and Apte M.V. (Pancreas 2003)
    991. The effects of moderate ethanol consumption on the liver of the monkey, Macaca fascicularis. (PubMed id 14634501)9 Ivester P....Cunningham C.C. (Alcohol. Clin. Exp. Res. 2003)
    992. Acquired and genetic susceptibility to cervical cancer. (PubMed id 14644338)9 Au W.W....Tyring S.K. (Mutat. Res. 2003)
    993. Astroglial CYP1B1 up-regulation in inflammatory/oxidative toxic conditions: IL-1beta effect and protection by N-acetylcysteine. (PubMed id 12565201)9 Malaplate-Armand C....Batt A.M. (Toxicol. Lett. 2003)
    994. [Alcoholism-related genetic alteration]. (PubMed id 14533098)9 Escarabajal M.D. (Rev Neurol 2003)
    995. Induction of cytochrome P450 enzymes in cultured precision-cut human liver slices. (PubMed id 12584154)9 Edwards R.J....Lake B.G. (Drug Metab. Dispos. 2003)
    996. GYKI-47261, a new AMPA [2-amino-3-(3-hydroxymethylisoxazole-4-yl)propionic acid] antagonist, is a CYP2E1 inducer. (PubMed id 14570761)9 TamA!si V....Monostory K. (Drug Metab. Dispos. 2003)
    997. Sex differences in the toxicokinetics of inhaled solvent vaporsin humans 1. m-Xylene. (PubMed id 14644617)9 ErnstgAYrd L....Johanson G. (Toxicol. Appl. Pharmacol. 2003)
    998. Impaired 6-hydroxychlorzoxazone elimination in patients with kidney disease: Implication for cytochrome P450 2E1 pharmacogenetic studies. (PubMed id 14663458)9 Nolin T.D....Frye R.F. (Clin. Pharmacol. Ther. 2003)
    999. [Role of polymorphic variants of cytochrome P450 genes (CYP1A1, CYP2E1) and microsomal epoxide hydrolase (mEPHX) in pathogenesis of cystic fibrosis and chronic respiratory tract diseases]. (PubMed id 14593914)9 Korytina G.F....Viktorova T.V. (Mol. Biol. (Mosk.) 2003)
    1000. Sex differences in the toxicokinetics of inhaled solvent vapors in humans 2. 2-propanol. (PubMed id 14644618)9 ErnstgAYrd L....Johanson G. (Toxicol. Appl. Pharmacol. 2003)
    1001. Phorbol ester induces CYP2E1 in astrocytes, through a protein kinase C- and tyrosine kinase-dependent mechanism. (PubMed id 12887687)9 Tindberg N. (J. Neurochem. 2003)
    1002. Current researches on breast cancer epidemiology in Korea. (PubMed id 14634505)9 Yoo K.Y. and Kang D. (Breast Cancer 2003)
    1003. Role of specific cytochrome P450 enzymes in the N-oxidation of the antiarrhythmic agent mexiletine. (PubMed id 12519691)9 LabbAc L....Turgeon J. ( the fate of foreign compounds in biological systems 2003)
    1004. Role of variability in explaining ethanol pharmacokinetics: research and forensic applications. (PubMed id 12489977)9 Norberg A....Gabrielsson J.L. (Clin Pharmacokinet 2003)
    1005. Genotyping of cytochrome p450 isoform genes is useful for forensic identification of cadaver. (PubMed id 14568772)9 Ogawa K....Shiono H. (Leg Med (Tokyo) 2003)
    1006. Evaluation of a microarray for genotyping polymorphisms related to xenobiotic metabolism and DNA repair. (PubMed id 14579748)9 Landi S....Canzian F. (BioTechniques 2003)
    1007. Cytochrome b5 reductase and cytochrome b5 support the CYP2E1-mediated activation of nitrosamines in a recombinant Ames test. (PubMed id 12646278)9 Mokashi V....Porter T.D. (Arch. Biochem. Biophys. 2003)
    1008. Contribution of human cytochrome p-450 isoforms to the metabolism of the simplest phenothiazine neuroleptic promazine. (PubMed id 12721102)9 WA^jcikowski J....Daniel W.A. (Br. J. Pharmacol. 2003)
    1009. Hepatotoxicity and mechanism of action of haloalkanes: carbon tetrachloride as a toxicological model. (PubMed id 12708612)9 Weber L.W....Stampfl A. (Crit. Rev. Toxicol. 2003)
    1010. Genetic and epigenetic factors in autoimmune reactions toward cytochrome P4502E1 in alcoholic liver disease. (PubMed id 12540792)9 Vidali M....Albano E. (Hepatology 2003)
    1011. Steatosis in chronic hepatitis C: association with increased messenger RNA expression of collagen I, tumor necrosis factor-alpha and cytochrome P450 2E1. (PubMed id 12653886)9 Gochee P.A....Powell E.E. (J. Gastroenterol. Hepatol. 2003)
    1012. The inhibition of superoxide production in EL4 lymphoma cells overexpressing growth hormone. (PubMed id 12784910)9 Arnold R.E. and Weigent D.A. (Immunopharmacol Immunotoxicol 2003)
    1013. Effects of cigarette smoking and carbon monoxide on chlorzoxazone and caffeine metabolism. (PubMed id 14586387)9 Benowitz N.L....Jacob P. (Clin. Pharmacol. Ther. 2003)
    1014. Comparative effects of thiazolidinediones on in vitro P450 enzyme induction and inhibition. (PubMed id 12642470)9 Sahi J....Sinz M.W. (Drug Metab. Dispos. 2003)
    1015. Cytochrome P450 2E1 (CYP2E1) is the principal enzyme responsible for urethane metabolism: comparative studies using CYP2E1-null and wild-type mice. (PubMed id 12704224)9 Hoffler U....Ghanayem B.I. (J. Pharmacol. Exp. Ther. 2003)
    1016. Individual sensitivity to DNA damage induced by styrene in vitro: influence of cytochrome p450, epoxide hydrolase and glutathione S-transferase genotypes. (PubMed id 12604177)9 Laffon B....MAcndez J. (Toxicology 2003)
    1017. Mechanisms of esophageal cancer development in Brazilians. (PubMed id 14644339)9 Ribeiro Pinto L.F....Andreollo N.A. (Mutat. Res. 2003)
    1018. Analysis of micronuclei in peripheral blood lymphocytes of traffic wardens: effects of exposure, metabolic genotypes, and inhibition of excision repair in vitro by ARA-C. (PubMed id 12605382)9 Leopardi P....Crebelli R. (Environ. Mol. Mutagen. 2003)
    1019. Coordinated intrahepatic and extrahepatic regulation of cytochrome p4502D6 in healthy subjects and in patients after liver transplantation. (PubMed id 12732845)9 Carcillo J.A....Branch R.A. (Clin. Pharmacol. Ther. 2003)
    1020. Induction of multidrug resistance-1 and cytochrome P450 mRNAs in human mononuclear cells by rifampin. (PubMed id 11744607)9 Asghar A....Hall S.D. (Drug Metab. Dispos. 2002)
    1021. Fondaparinux sodium is not metabolised in mammalian liver fractions and does not inhibit cytochrome P450-mediated metabolism of concomitant drugs. (PubMed id 12383041)9 Lieu C....Vos R. (Clin Pharmacokinet 2002)
    1022. Molecular modeling of human cytochrome P450-substrate interactions. (PubMed id 11996012)9 Lewis D.F. (Drug Metab. Rev. 2002)
    1023. Increased cytochrome P-450 2E1 expression sensitizes hepatocytes to c-Jun-mediated cell death from TNF-alpha. (PubMed id 11804847)9 Liu H....Czaja M.J. (Am. J. Physiol. Gastrointest. Liver Physiol. 2002)
    1024. Multiple cytochrome P450 enzymes responsible for the oxidative metabolism of the substituted (S)-3-phenylpiperidine, (S,S)-3-[3-(methylsulfonyl)phenyl]-1-propylpiperidine hydrochloride, in human liver microsomes. (PubMed id 12433806)9 Wienkers L.C. and Wynalda M.A. (Drug Metab. Dispos. 2002)
    1025. Genetic susceptibility of term pregnant women to oxidative damage. (PubMed id 11888709)9 Hong Y.C....Christiani D.C. (Toxicol. Lett. 2002)
    1026. Free radical mechanisms in immune reactions associated with alcoholic liver disease. (PubMed id 11796198)9 Albano E. (amp 2002)
    1027. Cytochrome P4502E1 phenotyping by the measurement of the chlorzoxazone metabolic ratio: assessment of its usefulness in workers exposed to styrene. (PubMed id 12172891)9 Haufroid V....Lison D. (Int Arch Occup Environ Health 2002)
    1028. S-adenosyl-L-methionine: its role in the treatment of liver disorders. (PubMed id 12418503)9 Lieber C.S. (Am. J. Clin. Nutr. 2002)
    1029. Role of human cytochrome P450 (CYP) in the metabolic activation of nitrosamine derivatives: application of genetically engineered Salmonella expressing human CYP. (PubMed id 12214673)9 Kamataki T....Ariyoshi N. (Drug Metab. Rev. 2002)
    1030. Cytochrome P450 (CYP) expression in human myeloblastic and lymphoid cell lines. (PubMed id 11913539)9 Nagai F....Tamura H.O. (amp 2002)
    1031. Expression and regulation of xenobiotic-metabolizing cytochrome P450 (CYP) enzymes in human lung. (PubMed id 12389869)9 Hukkanen J....Raunio H. (Crit. Rev. Toxicol. 2002)
    1032. NAD(P)H:quinone oxidoreductase (NQO1) polymorphism, exposure to benzene, and predisposition to disease: a HuGE review. (PubMed id 11882782)9 Nebert D.W....Oakley G.G. (Genet. Med. 2002)
    1033. Comparative effect of colchicine and colchiceine on cytotoxicity and CYP gene expression in primary human hepatocytes. (PubMed id 12020594)9 Dvorak Z....Maurel P. (Toxicol In Vitro 2002)
    1034. Feasibility of collecting buccal cell DNA by mail in a cohort study. (PubMed id 11401922)9 Le Marchand L....Kolonel L.N. (amp 2001)
    1035. Comparison of the stability of some major cytochrome P450 and conjugation reactions in rat, dog and human hepatocyte monolayers. (PubMed id 11554432)9 Ubeaud G....Coassolo P. (Eur J Drug Metab Pharmacokinet 2001)
    1036. Cytochrome P450 4A11 expression in human keratinocytes: effects of ultraviolet irradiation. (PubMed id 11736898)9 Gonzalez M.C....Migliore-Samour D. (Br. J. Dermatol. 2001)
    1037. Mechanisms of inhibition of chemical toxicity and carcinogenesis by diallyl sulfide (DAS) and related compounds from garlic. (PubMed id 11238812)9 Yang C.S....Smith T.J. (J. Nutr. 2001)
    1038. Examination of a CYP2E1 repeat polymorphism in a monkey model of alcohol abuse. (PubMed id 11505041)9 Walker S.J....Vrana K.E. (Alcohol. Clin. Exp. Res. 2001)
    1039. Assessment of cytochrome P450 activity by a five-drug cocktail approach. (PubMed id 11719732)9 Zhu B....Zhou H.H. (Clin. Pharmacol. Ther. 2001)
    1040. Liver diseases by alcohol and hepatitis C: early detection and new insights in pathogenesis lead to improved treatment. (PubMed id 11268819)9 Lieber C.S. (Am J Addict 2001)
    1041. CYP2E1-dependent toxicity and up-regulation of antioxidant genes. (PubMed id 11173976)9 MarA- M....Cederbaum A.I. (J. Biomed. Sci. 2001)
    1042. Genetic determinants of ethanol-induced liver damage. (PubMed id 11471570)9 Monzoni A....Giacca M. (Mol. Med. 2001)
    1043. In vitro evaluation of valproic acid as an inhibitor of human cytochrome P450 isoforms: preferential inhibition of cytochrome P450 2C9 (CYP2C9). (PubMed id 11736863)9 Wen X....Backman J.T. (Br J Clin Pharmacol 2001)
    1044. Oxidative stress, metabolism of ethanol and alcohol-related diseases. (PubMed id 11173977)9 Zima T....Popov P. (J. Biomed. Sci. 2001)
    1045. Acetaminophen induces apoptosis of C6 glioma cells by activating the c-Jun NH(2)-terminal protein kinase-related cell death pathway. (PubMed id 11562448)9 Bae M.A....Song B.J. (Mol. Pharmacol. 2001)
    1046. [Possible interaction between ethanol and drugs and their significance for drug therapy in the elderly]. (PubMed id 11432125)9 Ramskogler K....Lesch O.M. (Wien. Klin. Wochenschr. 2001)
    1047. Involvement of CYP2E1 and carboxylesterase enzymes in vinyl carbamate metabolism in human lung microsomes. (PubMed id 11181492)9 Forkert P.G....Reid K. (Drug Metab. Dispos. 2001)
    1048. Biomarkers for assessing occupational exposures to 1,3-butadiene. (PubMed id 11397405)9 Albertini R.J....Ward J.B. (Chem. Biol. Interact. 2001)
    1049. Predicting the mutagenicity of tobacco-related N-nitrosamines in humans using 11 strains of Salmonella typhimurium YG7108, each coexpressing a form of human cytochrome P450 along with NADPH-cytochrome P450 reductase. (PubMed id 11774366)9 Fujita K. and Kamataki T. (Environ. Mol. Mutagen. 2001)
    1050. [Classification of alcohol metabolizing enzymes and polymorphisms--specificity in Japanese]. (PubMed id 11398342)9 Harada S. (amp 2001)
    1051. The expression of cytochrome P450 enzymes in human breast tumours and normal breast tissue. (PubMed id 11767004)9 Iscan M....Raunio H. (Breast Cancer Res. Treat. 2001)
    1052. Cytochrome b(5) coexpression increases the CYP2E1-dependent mutagenicity of dialkylnitrosamines in methyltransferase-deficient strains of Salmonella typhimurium. (PubMed id 11733072)9 Cooper M.T. and Porter T.D. (Mutat. Res. 2001)
    1053. Role of human liver cytochrome P4503A in the metabolism of etoricoxib, a novel cyclooxygenase-2 selective inhibitor. (PubMed id 11353749)9 Kassahun K....Rodrigues A.D. (Drug Metab. Dispos. 2001)
    1054. Characterization of xenobiotic-metabolizing cytochrome P450 (CYP) forms in ringed and grey seals from the Baltic Sea and reference sites. (PubMed id 11166678)9 Nyman M....Pelkonen O. (amp 2001)
    1055. CYP2B6 and CYP2C19 as the major enzymes responsible for the metabolism of selegiline, a drug used in the treatment of Parkinson's disease, as revealed from experiments with recombinant enzymes. (PubMed id 11602525)9 Hidestrand M....Ingelman-Sundberg M. (Drug Metab. Dispos. 2001)
    1056. [Stable expression of human cytochrome P450 2E1 cDNA in nasopharyngeal cancer cell line CNE-2]. (PubMed id 12536525)9 Wang S.L....Chen Z.C. (Hunan Yi Ke Da Xue Xue Bao 2001)
    1057. Adenovirus-mediated overexpression of catalase in the cytosolic or mitochondrial compartment protects against cytochrome P450 2E1-dependent toxicity in HepG2 cells. (PubMed id 11071897)9 Bai J. and Cederbaum A.I. (J. Biol. Chem. 2001)
    1058. Understanding the role of xenobiotic-metabolism in chemical carcinogenesis using gene knockout mice. (PubMed id 11376689)9 Gonzalez F.J. and Kimura S. (Mutat. Res. 2001)
    1059. Inhibition of human CYP1A2 activity in vitro by methylxanthines: potent competitive inhibition by 8-phenyltheophylline. (PubMed id 11465391)9 Murray S....Edwards R.J. ( the fate of foreign compounds in biological systems 2001)
    1060. Metabolism of styrene in the human liver in vitro: interindividual variation and enantioselectivity. (PubMed id 11407535)9 Wenker M.A....De Wolff F.A. ( the fate of foreign compounds in biological systems 2001)
    1061. Novel metabolic pathway of estrone and 17beta-estradiol catalyzed by cytochrome P-450. (PubMed id 10640505)9 Ohe T....Mashino T. (Drug Metab. Dispos. 2000)
    1062. Enzymic catalysis of the accumulation of acetaldehyde from ethanol in human prenatal cephalic tissues: evaluation of the relative contributions of CYP2E1, alcohol dehydrogenase, and catalase/peroxidases. (PubMed id 11003211)9 Person R.E....Juchau M.R. (Alcohol. Clin. Exp. Res. 2000)
    1063. Oxidation of the novel oxazolidinone antibiotic linezolid in human liver microsomes. (PubMed id 10950842)9 Wynalda M.A....Wienkers L.C. (Drug Metab. Dispos. 2000)
    1064. Cytochromes P450 2A6, 2E1, and 3A and production of protein-aldehyde adducts in the liver of patients with alcoholic and non-alcoholic liver diseases. (PubMed id 11131450)9 NiemelAo O....Pasanen M. (J. Hepatol. 2000)
    1065. Selective and potent inhibition of human CYP2C19 activity by a conformationally targeted antipeptide antibody. (PubMed id 10859141)9 Schulz-Utermoehl T....Hansen K.T. (Drug Metab. Dispos. 2000)
    1066. Cytochrome P-450 2E1 activity and oxidative stress in alcoholic patients. (PubMed id 10684785)9 Dupont I....Lucas D. (Alcohol Alcohol. 2000)
    1067. Inhibitory effects of amiodarone and its N-deethylated metabolite on human cytochrome P450 activities: prediction of in vivo drug interactions. (PubMed id 10718780)9 Ohyama K....Yokoi T. (Br J Clin Pharmacol 2000)
    1068. In vitro inhibition and induction of human hepatic cytochrome P450 enzymes by modafinil. (PubMed id 10820139)9 Robertson P....Parkinson A. (Drug Metab. Dispos. 2000)
    1069. Role of alcohol dehydrogenase 3 and cytochrome P-4502E1 genotypes in susceptibility to cancers of the upper aerodigestive tract. (PubMed id 10925369)9 Bouchardy C....Benhamou S. (Int. J. Cancer 2000)
    1070. Impact of genetic polymorphisms in cytochrome P450 2E1 and glutathione S-transferases M1, T1, and P1 on susceptibility to esophageal cancer among high-risk individuals in China. (PubMed id 10868687)9 Tan W....Lin D.X. (amp 2000)
    1071. Combined analysis of germline polymorphisms of p53, GSTM1, GSTT1, CYP1A1, and CYP2E1: relation to the incidence rate of cervical carcinoma. (PubMed id 10813720)9 Kim J.W....Namkoong S.E. (Cancer 2000)
    1072. [Cytochrome P450 1A1 and cytochrome P450 2E1 gene polymorphisms in Guangzhou Hans]. (PubMed id 10932010)9 Wang J....Chen B. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2000)
    1073. Interindividual variance of cytochrome P450 forms in human hepatic microsomes: correlation of individual forms with xenobiotic metabolism and implications in risk assessment. (PubMed id 11067776)9 Snawder J.E. and Lipscomb J.C. (Regul. Toxicol. Pharmacol. 2000)
    1074. CYP2E1 overexpression in HepG2 cells induces glutathione synthesis by transcriptional activation of gamma-glutamylcysteine synthetase. (PubMed id 10748080)9 MarA- M. and Cederbaum A.I. (J. Biol. Chem. 2000)
    1075. [Biomarkers of gentotoxic risk and metabolic polymorphism]. (PubMed id 11189784)9 Pavanello S. and Clonfero E. (Med Lav 2000)
    1076. Human skin absorption and metabolism of the contact allergens, cinnamic aldehyde, and cinnamic alcohol. (PubMed id 11042091)9 Smith C.K....Hotchkiss S.A. (Toxicol. Appl. Pharmacol. 2000)
    1077. Gene expression in distinct regions of the heart. (PubMed id 10768437)9 Thum T. and Borlak J. (Lancet 2000)
    1078. The induction of the human hepatic CYP2E1 gene by interleukin 4 is transcriptional and regulated by protein kinase C. (PubMed id 11101004)9 Lagadic-Gossmann D....Corcos L. (Cell Biol. Toxicol. 2000)
    1079. Evidence for the catalysis of dextromethorphan O-demethylation by a CYP2D6-like enzyme in pig liver. (PubMed id 10806376)9 Jurima-Romet M....Nowakowska M. (Toxicol In Vitro 2000)
    1080. Role of polymorphic CYP2E1 and CYP2D6 genes in NNK-induced chromosome aberrations in cultured human lymphocytes. (PubMed id 10803680)9 Abdel-Rahman S.Z....Hamada F.A. (Pharmacogenetics 2000)
    1081. Effect of colchicine and its derivatives on the expression of selected isoforms of cytochrome P450 in primary cultures of human hepatocytes. (PubMed id 11144118)9 DvorA!k Z....Maurel P. (Acta Univ Palacki Olomuc Fac Med 2000)
    1082. Role of human cytochrome P450 3A4 in metabolism of medroxyprogesterone acetate. (PubMed id 10955816)9 Kobayashi K....Chiba K. (Clin. Cancer Res. 2000)
    1083. ALCOHOL: its metabolism and interaction with nutrients. (PubMed id 10940340)9 Lieber C.S. (Annu. Rev. Nutr. 2000)
    1084. Genetic polymorphism and cancer risk. (PubMed id 11122850)9 Clapper M.L. (Curr Oncol Rep 2000)
    1085. Mutagenicity of nitrosamines in methyltransferase-deficient strains of Salmonella typhimurium coexpressing human cytochrome P450 2E1 and reductase. (PubMed id 11035158)9 Cooper M.T. and Porter T.D. (Mutat. Res. 2000)
    1086. Modulation of xenobiotic metabolism and oxidative stress in chronic streptozotocin-induced diabetic rats fed with Momordica charantia fruit extract. (PubMed id 10711628)9 Raza H....Sharma A.K. (J. Biochem. Mol. Toxicol. 2000)
    1087. In vitro identification of the cytochrome P450 isoform responsible for the metabolism of alpha-dihydroergocryptine. (PubMed id 11197065)9 Althaus M....Appel K. ( the fate of foreign compounds in biological systems 2000)
    1088. Dietary lipids affect human ethanol-inducible CYP2E1 gene expression in vivo in mononuclear cells. (PubMed id 10972199)9 Boucher P....Vallon J.J. (Life Sci. 2000)
    1089. Propofol inhibits renal cytochrome P450 activity and enflurane defluorination in vitro in hamsters. (PubMed id 10930209)9 Chen T.L....Ueng T.H. (Can J Anaesth 2000)
    1090. On the recognition of mammalian microsomal cytochrome P450 substrates and their characteristics: towards the prediction of human p450 substrate specificity and metabolism. (PubMed id 10856424)9 Lewis D.F. (Biochem. Pharmacol. 2000)
    1091. Inducers of cytochrome P450 2E1 enhance methotrexate-induced hepatocytoxicity. (PubMed id 10614715)9 Neuman M.G....Shear N.H. (Clin. Biochem. 1999)
    1092. Effects of obesity on the cytochrome P450 enzyme system. (PubMed id 10027478)9 Kotlyar M. and Carson S.W. (Int J Clin Pharmacol Ther 1999)
    1093. The application of comparative genomic hybridization and fluorescence in situ hybridization to the characterization of genotoxicity screening tester strains AHH-1 and MCL-5. (PubMed id 10390510)9 Corso C. and Parry E.M. (Mutagenesis 1999)
    1094. Increased toxicity of cocaine on human hepatocytes induced by ethanol: role of GSH. (PubMed id 10535748)9 Ponsoda X....Castell J.V. (Biochem. Pharmacol. 1999)
    1095. Expression of xenobiotic-metabolizing CYPs in human pulmonary tissue. (PubMed id 10445407)9 Raunio H....Edwards R.J. (Exp. Toxicol. Pathol. 1999)
    1096. A multiplex-PCR/RFLP procedure for simultaneous CYP2E1, mEH and GSTM1 genotyping. (PubMed id 10465337)9 Salama S.A....Au W.W. (Cancer Lett. 1999)
    1097. Estimation of the dermal absorption of m-xylene vapor in humans using breath sampling and physiologically based pharmacokinetic analysis. (PubMed id 10353308)9 Loizou G.D....Cocker J. (Toxicol. Sci. 1999)
    1098. Relationship between cytochrome P450 catalytic cycling and stability: fast degradation of ethanol-inducible cytochrome P450 2E1 (CYP2E1) in hepatoma cells is abolished by inactivation of its electron donor NADPH-cytochrome P450 reductase. (PubMed id 10333489)9 Zhukov A. and Ingelman-Sundberg M. (Biochem. J. 1999)
    1099. Role of a potent inhibitory monoclonal antibody to cytochrome P-450 3A4 in assessment of human drug metabolism. (PubMed id 10525096)9 Mei Q....Shou M. (J. Pharmacol. Exp. Ther. 1999)
    1100. Gender-related differences in pharmacokinetics and their clinical significance. (PubMed id 10583696)9 Tanaka E. (J Clin Pharm Ther 1999)
    1101. Phase I and phase II drug-metabolizing enzymes are expressed and heterogeneously distributed in the biliary epithelium. (PubMed id 10573530)9 Lakehal F....Housset C. (Hepatology 1999)
    1102. Cyclin D1, glutathione S-transferase, and cytochrome P450 genotypes and outcome in patients with upper aerodigestive tract cancers: assessment of the importance of individual genes using multivariate analysis. (PubMed id 10498401)9 Matthias C....Strange R.C. (amp 1999)
    1103. Comparison of the polymorphic regions of the cytochrome P450 CYP2E1 gene of humans and patas and cynomolgus monkeys. (PubMed id 10357784)9 Chhabra S.K....Shiao Y.H. (Carcinogenesis 1999)
    1104. Genetic polymorphisms of tobacco- and alcohol-related metabolizing enzymes and oral cavity cancer. (PubMed id 10521794)9 Katoh T....Kawamoto T. (Int. J. Cancer 1999)
    1105. Involvement of CYP2E1 as A low-affinity enzyme in phenacetin O-deethylation in human liver microsomes. (PubMed id 10421611)9 Kobayashi K....Chiba K. (Drug Metab. Dispos. 1999)
    1106. Activation of phenacetin O-deethylase activity by alpha-naphthoflavone in human liver microsomes. (PubMed id 10548449)9 Nakajima M....Yokoi T. ( the fate of foreign compounds in biological systems 1999)
    1107. Effect of cigarette smoke on the mutagenic activation of environmental carcinogens by rodent liver. (PubMed id 10517990)9 Koide A....Mori Y. (Mutat. Res. 1999)
    1108. Cytochrome P4502E1 genetic polymorphisms and lung cancer in a Taiwanese population. (PubMed id 10574678)9 Wang S.L....Lin P. (Lung Cancer 1999)
    1109. A systematic review of genetic polymorphisms and breast cancer risk. (PubMed id 10548311)9 Dunning A.M....Easton D.F. (amp 1999)
    1110. Familial and sporadic cases of nasopharyngeal carcinoma in Taiwan. (PubMed id 10216473)9 Ung A....Hildesheim A. (Anticancer Res. 1999)
    1111. Isoniazid drug and food interactions. (PubMed id 10334118)9 Self T.H....Bronze M.S. (Am. J. Med. Sci. 1999)
    1112. Update: genetic polymorphism of drug metabolizing enzymes in humans. (PubMed id 10583694)9 Tanaka E. (J Clin Pharm Ther 1999)
    1113. Study of the association between cytochromes P450 2D6 and 2E1 genotypes and the risk of drug and chemical induced idiosyncratic aplastic anaemia. (PubMed id 10050706)9 Marsh J.C....Tucker G.T. (Br. J. Haematol. 1999)
    1114. Metabolism of diallyl disulfide by human liver microsomal cytochromes P-450 and flavin-containing monooxygenases. (PubMed id 10383929)9 Teyssier C....Siess M.H. (Drug Metab. Dispos. 1999)
    1115. Toxicokinetic interactions between orally ingested chlorzoxazone and inhaled acetone or toluene in male volunteers. (PubMed id 10353310)9 ErnstgAYrd L....LAPf A. (Toxicol. Sci. 1999)
    1116. Characterization of Phase I and Phase II hepatic drug metabolism activities in a panel of human liver preparations. (PubMed id 10359459)9 Iyer K.R. and Sinz M.W. (Chem. Biol. Interact. 1999)
    1117. Role of human CYP2B6 in S-mephobarbital N-demethylation. (PubMed id 10570024)9 Kobayashi K....Yamamoto T. (Drug Metab. Dispos. 1999)
    1118. Characterization of hepatic cytochrome P450 isozyme composition in the transgenic rat expressing low level human growth hormone. (PubMed id 10647907)9 Takahashi J....Fujita S. ( the fate of foreign compounds in biological systems 1999)
    1119. Role of gene knockout mice in understanding the mechanisms of chemical toxicity and carcinogenesis. (PubMed id 10503904)9 Gonzalez F.J. and Kimura S. (Cancer Lett. 1999)
    1120. Homology modelling of human cytochromes P450 involved in xenobiotic metabolism and rationalization of substrate selectivity. (PubMed id 10445400)9 Lewis D.F. (Exp. Toxicol. Pathol. 1999)
    1121. Mutations in the exons and exon-intron junction regions of human cytochrome P-4502E1 gene and alcoholism. (PubMed id 10235271)9 Itoga S....Nakai T. (Alcohol. Clin. Exp. Res. 1999)
    1122. Genotypes of alcohol-metabolizing enzymes in relation to alcoholic chronic pancreatitis in Japan. (PubMed id 10235286)9 Maruyama K....Matsuno M. (Alcohol. Clin. Exp. Res. 1999)
    1123. Covalent binding of trichloroethylene to proteins in human and rat hepatocytes. (PubMed id 9704819)9 Griffin J.M....Pumford N.R. (Toxicol. Lett. 1998)
    1124. [Genetic polymorphism of drug metabolizing enzymes: new mutations in CYP2D6 and CYP2A6 genes in Japanese]. (PubMed id 9755457)9 Yokoi T. and Kamataki T. (Nippon Yakurigaku Zasshi 1998)
    1125. Human hepatocyte growth factor down-regulates the expression of cytochrome P450 isozymes in human hepatocytes in primary culture. (PubMed id 9454825)9 Donato M.T....Castell J.V. (J. Pharmacol. Exp. Ther. 1998)
    1126. Formation of a novel topotecan metabolite in the hormone-independent human prostate carcinoma cell lines DU-145 and PC-3. (PubMed id 9703938)9 Platzer P....JAoger W. (Anticancer Res. 1998)
    1127. Single-dose disulfiram does not inhibit CYP2A6 activity. (PubMed id 9695717)9 Kharasch E.D....Thummel K.E. (Clin. Pharmacol. Ther. 1998)
    1128. Human hepatic stellate cells express class I alcohol dehydrogenase and aldehyde dehydrogenase but not cytochrome P4502E1. (PubMed id 9537862)9 Casini A....Surrenti C. (J. Hepatol. 1998)
    1129. Cytochrome P450 2E1 DraI polymorphisms in lung cancer in minority populations. (PubMed id 9456237)9 Wu X....Spitz M.R. (amp 1998)
    1130. Association studies of polymorphisms of CYP2E1 gene in alcoholics with cirrhosis, antisocial personality, and normal controls. (PubMed id 9660317)9 Parsian A....Zhang Z.H. (Alcohol. Clin. Exp. Res. 1998)
    1131. Production of DNA strand breaks by N-nitrosodimethylamine and 2-amino-3-methylimidazo[4,5-f]quinoline in THLE cells expressing human CYP isoenzymes and inhibition by sulforaphane. (PubMed id 9675256)9 BarcelA^ S....Chipman J.K. (Mutat. Res. 1998)
    1132. Oxidation of acetaminophen to its toxic quinone imine and nontoxic catechol metabolites by baculovirus-expressed and purified human cytochromes P450 2E1 and 2A6. (PubMed id 9548799)9 Chen W....Nelson S.D. (Chem. Res. Toxicol. 1998)
    1133. [Perfusion and metabolism of liver and splanchnic nerve area under sevoflurane anesthesia]. (PubMed id 9893876)9 Schindler E. and Hempelmann G. (Anaesthesist 1998)
    1134. Recent advances in understanding the molecular basis of polymorphisms in genes encoding cytochrome P450 enzymes. (PubMed id 10022246)9 Daly A.K....Smart J. (Toxicol. Lett. 1998)
    1135. Cytotoxicity and apoptosis produced by arachidonic acid in HepG2 cells overexpressing human cytochrome P-4502E1. (PubMed id 9660301)9 Chen Q....Cederbaum A.I. (Alcohol. Clin. Exp. Res. 1998)
    1136. A simple mouthwash method for obtaining genomic DNA in molecular epidemiological studies. (PubMed id 9718225)9 Lum A. and Le Marchand L. (amp 1998)
    1137. Alterations of the catalytic activities of drug-metabolizing enzymes in cultures of human liver slices. (PubMed id 9806947)9 VandenBranden M....Jensen C.B. (Drug Metab. Dispos. 1998)
    1138. Characterization of cytochrome P450 enzymes in human breast tissue from reduction mammaplasties. (PubMed id 9506744)9 Hellmold H....Gustafsson J.A. (J. Clin. Endocrinol. Metab. 1998)
    1139. All-trans-retinoic acid modulation of drug-metabolizing enzyme activities: investigation with selective metabolic drug probes. (PubMed id 9443626)9 Adedoyin A....Trump D.L. (Cancer Chemother. Pharmacol. 1998)
    1140. Development of a comprehensive panel of antibodies against the major xenobiotic metabolising forms of cytochrome P450 in humans. (PubMed id 9744576)9 Edwards R.J....Boobis A.R. (Biochem. Pharmacol. 1998)
    1141. Enhanced expression of cytochrome P450 in stomach cancer. (PubMed id 9569036)9 Murray G.I....Melvin W.T. (Br. J. Cancer 1998)
    1142. Role of CYP2A5 and 2G1 in acetaminophen metabolism and toxicity in the olfactory mucosa of the Cyp1a2(-/-) mouse. (PubMed id 9714300)9 Genter M.B....Nebert D.W. (Biochem. Pharmacol. 1998)
    1143. Expression of xenobiotic-metabolizing cytochrome P450s in human pulmonary tissues. (PubMed id 9442317)9 Raunio H....Anttila S. (Arch. Toxicol. Suppl. 1998)
    1144. Genotyping metabolic polymorphisms in a cohort of Caucasians and single strand conformation polymorphism analysis of point mutations in human hprt exons 7 and 8. (PubMed id 9820953)9 Krause G....Scherer G. (Electrophoresis 1998)
    1145. Polymorphic CYP genes and disease predisposition--what have the studies shown so far? (PubMed id 10022250)9 Watanabe M. (Toxicol. Lett. 1998)
    1146. The RsaI polymorphism of CYP2E1 and susceptibility to alcoholic liver disease in Caucasians: effect on age of presentation and dependence on alcohol dehydrogenase genotype. (PubMed id 9731720)9 Grove J....Day C.P. (Pharmacogenetics 1998)
    1147. Ethanol interactions with other cytochrome P450 substrates including drugs, xenobiotics, and carcinogens. (PubMed id 9922992)9 DjordjeviA8 D....StefanoviA8 V. (Pathol. Biol. 1998)
    1148. Catalytic activities, protein- and mRNA-expression of cytochrome P450 isoenzymes in intestinal cell lines. (PubMed id 9622846)9 Lampen A....Borlak J.T. ( the fate of foreign compounds in biological systems 1998)
    1149. [Interindividual differences in efficacy and toxicity induced by therapeutic drugs and xenobiotics in relation to genetic polymorphisms in xenobiotic metabolizing enzymes]. (PubMed id 10097514)9 Ozawa S. (Kokuritsu Iyakuhin Shokuhin Eisei Kenkyusho Hokoku 1998)
    1150. Human biotransformation of bropirimine. Characterization of the major bropirimine oxidative metabolites formed in vitro. (PubMed id 9763414)9 Wynalda M.A....Wienkers L.C. (Drug Metab. Dispos. 1998)
    1151. Chlorzoxazone metabolism by winter flounder liver microsomes: evidence for existence of a CYP2E1-like isoform in teleosts. (PubMed id 9705891)9 Wall K.L. and Crivello J. (Toxicol. Appl. Pharmacol. 1998)
    1152. Effects on sister chromatid exchange frequency of aldehyde dehydrogenase 2 genotype and smoking in vinyl chloride workers. (PubMed id 9838066)9 Wong R.H....Cheng T.J. (Mutat. Res. 1998)
    1153. Influence of genetic admixture on polymorphisms of drug-metabolizing enzymes: analyses of mutations on NAT2 and C gamma P2E1 genes in a mixed Hispanic population. (PubMed id 9663176)9 MartA-nez C....BenA-tez J. (Clin. Pharmacol. Ther. 1998)
    1154. Comparative studies of MCL-5 cells and human lymphocytes for detecting indirect-acting clastogens. (PubMed id 9508364)9 Yamakage K....Tanaka N. (Mutat. Res. 1998)
    1155. Cytotoxicity and apoptosis produced by cytochrome P450 2E1 in Hep G2 cells. (PubMed id 9547353)9 Chen Q. and Cederbaum A.I. (Mol. Pharmacol. 1998)
    1156. Human buprenorphine N-dealkylation is catalyzed by cytochrome P450 3A4. (PubMed id 9698298)9 Kobayashi K....Kuroiwa Y. (Drug Metab. Dispos. 1998)
    1157. Characterization of the selectivity and mechanism of human cytochrome P450 inhibition by the human immunodeficiency virus-protease inhibitor nelfinavir mesylate. (PubMed id 9660842)9 Lillibridge J.H....Lee C.A. (Drug Metab. Dispos. 1998)
    1158. Apoptosis and alcoholic liver disease. (PubMed id 9606815)9 Nanji A.A. (Semin. Liver Dis. 1998)
    1159. Use of chlorzoxazone as an in vivo probe of cytochrome P450 2E1: choice of dose and phenotypic trait measure. (PubMed id 9597564)9 Frye R.F....Branch R.A. (J Clin Pharmacol 1998)
    1160. Oxidation kinetics of ethanol by human cytochrome P450 2E1. Rate-limiting product release accounts for effects of isotopic hydrogen substitution and cytochrome b5 on steady-state kinetics. (PubMed id 9368031)9 Bell L.C. and Guengerich F.P. (J. Biol. Chem. 1997)
    1161. Metabolism and toxicity of 2-methylpropene (isobutene)--a review. (PubMed id 9189652)9 Cornet M. and Rogiers V. (Crit. Rev. Toxicol. 1997)
    1162. Cytochrome P-4502E1-dependent formation of trifluoroacetyl adducts from halothane by transduced HepG2 cells. (PubMed id 9438519)9 Feierman D.E. and Melnikov Z. (Alcohol. Clin. Exp. Res. 1997)
    1163. [O-ethyl 14C]phenacetin O-deethylase activity in human liver microsomes. (PubMed id 9311627)9 Rodrigues A.D....Roberts E.M. (Drug Metab. Dispos. 1997)
    1164. Glutathione S-transferase and cytochrome P450 genotypes as risk factors for laryngeal carcinoma. (PubMed id 9065651)9 Jahnke V....Fryer A. (Eur Arch Otorhinolaryngol 1997)
    1165. Clastogenic and aneugenic effects of tamoxifen and some of its analogues in hepatocytes from dosed rats and in human lymphoblastoid cells transfected with human P450 cDNAs (MCL-5 cells). (PubMed id 9054622)9 Styles J.A....Smith L.L. (Carcinogenesis 1997)
    1166. Lymphocyte activation in allergic reactions elicited by small-molecular-weight compounds. (PubMed id 9130514)9 Merk H.F....RA1bben A. (Int. Arch. Allergy Immunol. 1997)
    1167. In vitro metabolism of simvastatin in humans [SBT]identification of metabolizing enzymes and effect of the drug on hepatic P450s. (PubMed id 9321523)9 Prueksaritanont T....Vyas K.P. (Drug Metab. Dispos. 1997)
    1168. Examination of purported probes of human CYP2B6. (PubMed id 9241656)9 Ekins S....Wrighton S.A. (Pharmacogenetics 1997)
    1169. Polymorphism of metabolizing genes and lung cancer histology: prevalence of CYP2E1 in adenocarcinoma. (PubMed id 9029171)9 El-Zein R.A....Au W.W. (Cancer Lett. 1997)
    1170. Genetic polymorphism of cytochrome P-4502E1 and mitochondrial aldehyde dehydrogenase in a Korean population. (PubMed id 9309300)9 Lee K.H.... Jeong H.S. (Alcohol. Clin. Exp. Res. 1997)
    1171. Posttranscriptional elevation of cytochrome P450 3A expression. (PubMed id 9070249)9 Zangar R.C....Novak R.F. (Biochem. Biophys. Res. Commun. 1997)
    1172. Cytochrome P450 isozymes involved in lisofylline metabolism to pentoxifylline in human liver microsomes. (PubMed id 9394024)9 Lee S.H. and Slattery J.T. (Drug Metab. Dispos. 1997)
    1173. The effect of omeprazole pretreatment on acetaminophen metabolism in rapid and slow metabolizers of S-mephenytoin. (PubMed id 9246016)9 Sarich T....Wright J. (Clin. Pharmacol. Ther. 1997)
    1174. Helicobacter pylori infection and genetic polymorphisms for cancer-related genes in gastric carcinogenesis. (PubMed id 9207980)9 Kato S....Shields P.G. (amp 1997)
    1175. Epidemiological characteristics and risk factors of hepatocellular carcinoma. (PubMed id 9407350)9 Chen C.J....Liaw Y.F. (J. Gastroenterol. Hepatol. 1997)
    1176. Detection of mRNA encoding xenobiotic-metabolizing cytochrome P450s in human bronchoalveolar macrophages and peripheral blood lymphocytes. (PubMed id 9364212)9 Hukkanen J....Raunio H. (Mol. Carcinog. 1997)
    1177. Cytochrome P450 4A and 2E1 expression in human kidney microsomes. (PubMed id 9113097)9 Amet Y....MAcnez J.F. (Biochem. Pharmacol. 1997)
    1178. Mutagenicity of vinyl chloride and its reactive metabolites, chloroethylene oxide and chloroacetaldehyde, in a metabolically competent human B-lymphoblastoid line. (PubMed id 9054586)9 Chiang S.Y....Skopek T.R. (Carcinogenesis 1997)
    1179. Competitive interactions between cytochromes P450 2A6 and 2E1 for NADPH-cytochrome P450 oxidoreductase in the microsomal membranes produced by a baculovirus expression system. (PubMed id 9185616)9 Tan Y....Yang C.S. (Arch. Biochem. Biophys. 1997)
    1180. Metabolism of phencyclidine by human liver microsomes. (PubMed id 9152594)9 Laurenzana E.M. and Owens S.M. (Drug Metab. Dispos. 1997)
    1181. CYP2E1 genetic polymorphisms and risk of nasopharyngeal carcinoma in Taiwan. (PubMed id 9274915)9 Hildesheim A....Chhabra S.K. (J. Natl. Cancer Inst. 1997)
    1182. Zonation of cytochrome P450 expression, drug metabolism and toxicity in liver. (PubMed id 9013193)9 Lindros K.O. (Gen. Pharmacol. 1997)
    1183. Combined genetic polymorphism and risk for development of lung cancer. (PubMed id 9434875)9 el-Zein R....Au W.W. (Mutat. Res. 1997)
    1184. Effect of cell density and epidermal growth factor on the inducible expression of CYP3A and CYP1A genes in human hepatocytes in primary culture. (PubMed id 9141435)9 Greuet J....Maurel P. (Hepatology 1997)
    1185. Benzene poisoning, a risk factor for hematological malignancy, is associated with the NQO1 609C--&gt;T mutation and rapid fractional excretion of chlorzoxazone. (PubMed id 9230185)9 Rothman N....Ross D. (Cancer Res. 1997)
    1186. Plasma membrane hydroxyethyl radical adducts cause antibody-dependent cytotoxicity in rat hepatocytes exposed to alcohol. (PubMed id 9207287)9 Clot P....Albano E. (Gastroenterology 1997)
    1187. The role of gastrointestinal factors in alcohol metabolism. (PubMed id 9373695)9 Seitz H.K. and PAPschl G. (Alcohol Alcohol. 1997)
    1188. The relationship between cytochrome P4502E1 activity and plasma fluoride levels after sevoflurane anesthesia in humans. (PubMed id 9322481)9 Wandel C....Martin E. (Anesth. Analg. 1997)
    1189. Selective fast degradation of cytochrome P-450 2E1 in serum-deprived hepatoma cells by a mechanism sensitive to inhibitors of vesicular transport. (PubMed id 9249006)9 Zhukov A. and Ingelman-Sundberg M. (Eur. J. Biochem. 1997)
    1190. No linkage of the cytochrome P-450IIE1 (CYP2E1) C1/C2 polymorphism to schizophrenia. (PubMed id 9154445)9 Iwahashi K....Suwaki H. (amp 1997)
    1191. Role of CYP2D6 in the N-hydroxylation of procainamide. (PubMed id 9352574)9 Lessard E....Turgeon J. (Pharmacogenetics 1997)
    1192. Cytotoxicity and apoptosis produced by arachidonic acid in Hep G2 cells overexpressing human cytochrome P4502E1. (PubMed id 9169410)9 Chen Q....Cederbaum A.I. (J. Biol. Chem. 1997)
    1193. Identification of the enzyme responsible for oxidative halothane metabolism: implications for prevention of halothane hepatitis. (PubMed id 8637342)9 Kharasch E.D....Thummel K.E. (Lancet 1996)
    1194. Detection of cytochrome P450 gene expression in human placenta in first trimester of pregnancy. (PubMed id 8694864)9 Hakkola J....Pasanen M. (Biochem. Pharmacol. 1996)
    1195. Active site topology of human cytochrome P450 2E1. (PubMed id 8924594)9 Mackman R....Ortiz de Montellano P.R. (Chem. Res. Toxicol. 1996)
    1196. [Genetic polymorphisms of drug-metabolizing enzymes and susceptibility to lung cancer--relevance to smoking]. (PubMed id 8838107)9 Uematsu F. (Nippon Rinsho 1996)
    1197. Human cytochrome P450 isoform specificity in the regioselective metabolism of toluene and o-, m- and p-xylene. (PubMed id 8558417)9 Tassaneeyakul W....Miners J.O. (J. Pharmacol. Exp. Ther. 1996)
    1198. Human drug-metabolizing enzyme polymorphisms: effects on risk of toxicity and cancer. (PubMed id 8639263)9 Nebert D.W....Puga A. (DNA Cell Biol. 1996)
    1199. Polymorphisms of ethanol-oxidizing enzymes in alcoholics with inactive ALDH2. (PubMed id 8834237)9 Higuchi S....Hayashida M. (Hum. Genet. 1996)
    1200. Evaluation of caffeine as a test drug for CYP1A2, NAT2 and CYP2E1 phenotyping in man by in vivo versus in vitro correlations. (PubMed id 9156694)9 Fuhr U....Staib A.H. (Pharmacogenetics 1996)
    1201. Expression of xenobiotic-metabolizing cytochrome P450 forms in human full-term placenta. (PubMed id 8619884)9 Hakkola J.... Raunio H. (Biochem. Pharmacol. 1996)
    1202. RsaI polymorphism at the cytochrome P4502E1 locus and risk of hepatocellular carcinoma. (PubMed id 8977352)9 Ladero J.M....BenA-tez J. (Gut 1996)
    1203. Differences in rates of benzene metabolism correlate with observed genotoxicity. (PubMed id 8560479)9 Kenyon E.M....Medinsky M.A. (Toxicol. Appl. Pharmacol. 1996)
    1204. Cytochrome P4502E1 genotypes, alcoholism, and alcoholic cirrhosis in Han Chinese and Atayal Natives of Taiwan. (PubMed id 8651460)9 Carr L.G....Yin S.J. (Alcohol. Clin. Exp. Res. 1996)
    1205. Development of human cytochrome P450-expressing cell lines: application in mutagenicity testing of ochratoxin A. (PubMed id 8542584)9 de Groene E.M....Horbach G.J. (Cancer Res. 1996)
    1206. Coexpression of mammalian cytochrome P450 and reductase in Escherichia coli. (PubMed id 8619611)9 Dong J. and Porter T.D. (Arch. Biochem. Biophys. 1996)
    1207. Increased hepatocyte CYP2E1 expression in a rat nutritional model of hepatic steatosis with inflammation. (PubMed id 8942745)9 Weltman M.D....Liddle C. (Gastroenterology 1996)

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    Entrez Gene: 1571 HGNC: 2631 AceView: CYP2E1 Ensembl:ENSG00000130649 euGenes: HUgn1571
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    PharmGKB entry for CYP2E1 Pharmacogenomics, SNPs, Pathways
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