Aliases for CYP2E1 Gene
External Ids for CYP2E1 Gene
Previous Symbols for CYP2E1 Gene
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is induced by ethanol, the diabetic state, and starvation. The enzyme metabolizes both endogenous substrates, such as ethanol, acetone, and acetal, as well as exogenous substrates including benzene, carbon tetrachloride, ethylene glycol, and nitrosamines which are premutagens found in cigarette smoke. Due to its many substrates, this enzyme may be involved in such varied processes as gluconeogenesis, hepatic cirrhosis, diabetes, and cancer. [provided by RefSeq, Jul 2008]
GeneCards Summary for CYP2E1 Gene
CYP2E1 (Cytochrome P450, Family 2, Subfamily E, Polypeptide 1) is a Protein Coding gene. Diseases associated with CYP2E1 include alcoholic hepatitis and drug-induced hepatitis. Among its related pathways are GPCR Pathway and Metabolism. GO annotations related to this gene include enzyme binding and iron ion binding. An important paralog of this gene is CYP2C19.
UniProtKB/Swiss-Prot for CYP2E1 Gene
Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms