Aliases for CYP2E1 Gene
Aliases for CYP2E1 Gene
- Cytochrome P450 Family 2 Subfamily E Member 1 2 3 5
- Cytochrome P450, Subfamily IIE (Ethanol-Inducible), Polypeptide 1 2 3
- Cytochrome P450, Family 2, Subfamily E, Polypeptide 1 2 3
- 4-Nitrophenol 2-Hydroxylase 3 4
- Cytochrome P450-J 3 4
- CYPIIE1 3 4
- CYP2E 3 4
- Flavoprotein-Linked Monooxygenase 3
- Microsomal Monooxygenase 3
External Ids for CYP2E1 Gene
- HGNC: 2631
- Entrez Gene: 1571
- Ensembl: ENSG00000130649
- OMIM: 124040
- UniProtKB: P05181
Previous HGNC Symbols for CYP2E1 Gene
- CYP2E
Previous GeneCards Identifiers for CYP2E1 Gene
- GC10P134255
- GC10P134470
- GC10P135256
- GC10P134814
- GC10P135229
- GC10P135352
- GC10P128882
Summaries for CYP2E1 Gene
-
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is induced by ethanol, the diabetic state, and starvation. The enzyme metabolizes both endogenous substrates, such as ethanol, acetone, and acetal, as well as exogenous substrates including benzene, carbon tetrachloride, ethylene glycol, and nitrosamines which are premutagens found in cigarette smoke. Due to its many substrates, this enzyme may be involved in such varied processes as gluconeogenesis, hepatic cirrhosis, diabetes, and cancer. [provided by RefSeq, Jul 2008]
GeneCards Summary for CYP2E1 Gene
CYP2E1 (Cytochrome P450 Family 2 Subfamily E Member 1) is a Protein Coding gene. Diseases associated with CYP2E1 include Fatty Liver Disease and Alcoholic Liver Cirrhosis. Among its related pathways are Phenytoin Pathway, Pharmacokinetics and Folate-Alcohol and Cancer Pathway. GO annotations related to this gene include enzyme binding and iron ion binding. An important paralog of this gene is CYP2C19.
UniProtKB/Swiss-Prot for CYP2E1 Gene
-
Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms.
No data available for Tocris Summary , fRNAdb sequence ontologies and piRNA Summary for CYP2E1 Gene
Genomics for CYP2E1 Gene
Regulatory Elements for CYP2E1 Gene
Enhancers for CYP2E1 Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around CYP2E1 on UCSC Golden Path with GeneCards custom track
Promoters for CYP2E1 Gene
| Ensembl Regulatory Elements (ENSRs) | TSS Distance (bp) | Size (bp) | Binding Sites for Transcription Factors within promoters |
|---|
ENSRs around CYP2E1 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for CYP2E1 Gene
- Chromosome:
- 10
- Start:
- 133,520,406 bp from pter
- End:
- 133,561,220 bp from pter
- Size:
- 40,815 bases
- Orientation:
- Plus strand
Genomic View for CYP2E1 Gene
Genes around CYP2E1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 10q26.3 by Ensembl
- 10q26.3 by Entrez Gene
- 10q26.3 by HGNC
CYP2E1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CYP2E1 Gene
Proteins for CYP2E1 Gene
-
Protein details for CYP2E1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P05181-CP2E1_HUMAN
- Recommended name:
- Cytochrome P450 2E1
- Protein Accession:
- P05181
- Q5VZD5
- Q6NWT9
- Q9UK47
Protein attributes for CYP2E1 Gene
- Size:
- 493 amino acids
- Molecular mass:
- 56849 Da
- Cofactor:
- Name=heme; Xref=ChEBI:CHEBI:30413;
- Quaternary structure:
- No Data Available
Protein Expression for CYP2E1 Gene
Selected DME Specific Peptides for CYP2E1 Gene
Post-translational modifications for CYP2E1 Gene
Other Protein References for CYP2E1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for CYP2E1
- Novus Biologicals Antibodies for CYP2E1
-
Cloud-Clone Corp. Antibodies for CYP2E1
- Invitrogen Antibodies for CYP2E1
- antibodies-online Antibodies for CYP2E1: See all 156
- GeneTex CYP2E1 antibody for CYP2E1
-
Santa Cruz Biotechnology (SCBT) Antibodies for CYP2E1
Protein Products
-
OriGene Purified Proteins for CYP2E1
- Search Origene for MassSpec and Protein Over-expression Lysates for CYP2E1
- Origene Custom Protein Services for CYP2E1
-
Cloud-Clone Corp. Proteins for CYP2E1
- antibodies-online Proteins for CYP2E1: See all 26
- Search antibodies-online for peptides
- Search GeneTex for Proteins for CYP2E1
Domains & Families for CYP2E1 Gene
Gene Families for CYP2E1 Gene
- HGNC:
- IUPHAR :
Protein Domains for CYP2E1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for CYP2E1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P05181- Family:
-
- Belongs to the cytochrome P450 family.
Function for CYP2E1 Gene
Molecular function for CYP2E1 Gene
- UniProtKB/Swiss-Prot CatalyticActivity:
- 4-nitrophenol + NADPH + O(2) = 4-nitrocatechol + NADP(+) + H(2)O.
- UniProtKB/Swiss-Prot Function:
- Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms.
- UniProtKB/Swiss-Prot Induction:
- By ethanol and isoniazid.
Enzyme Numbers (IUBMB) for CYP2E1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004497 | monooxygenase activity | IDA | 19651758 |
| GO:0008395 | steroid hydroxylase activity | IBA | -- |
| GO:0019899 | enzyme binding | IPI | 15680923 |
Phenotypes for CYP2E1 Gene
- MGI mutant phenotypes for CYP2E1:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for CYP2E1:
Animal Models for CYP2E1 Gene
- MGI Knock Outs for CYP2E1:
-
- Cyp2e1 tm1Gonz
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for CYP2E1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CYP2E1 gene
- Search ViGene Biosciences for CYP2E1
CRISPR Products
-
OriGene CRISPR knockouts for CYP2E1
-
Santa Cruz Biotechnology (SCBT) CRISPR for CYP2E1
- GenScript: Design CRISPR guide RNA sequences for CYP2E1
miRNA for CYP2E1 Gene
- miRTarBase miRNAs that target CYP2E1
miRNA Products
- Search ViGene Biosciences for CYP2E1
Clone Products
- OriGene clones in human for CYP2E1
- OriGene ORF clones in human,mouse,rat for CYP2E1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for CYP2E1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for CYP2E1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for CYP2E1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CYP2E1 gene
Flow Cytometry Products
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CYP2E1 Gene
Localization for CYP2E1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CYP2E1 Gene
- Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
| Compartment | Confidence |
|---|---|
| endoplasmic reticulum | 5 |
| mitochondrion | 4 |
| cytosol | 2 |
| extracellular | 2 |
| golgi apparatus | 2 |
| nucleus | 2 |
| peroxisome | 2 |
| plasma membrane | 2 |
| lysosome | 1 |
| vacuole | 1 |
No data available for Gene Ontology (GO) - Cellular Components for CYP2E1 Gene
Pathways & Interactions for CYP2E1 Gene
More details on SuperPathways for CYP2E1| Superpath | Contained pathways | ||
|---|---|---|---|
| 1 | Metabolism of xenobiotics by cytochrome P450 | ||
| 2 | Acetaminophen Pathway (therapeutic doses), Pharmacokinetics | ||
| 3 | Phenytoin Pathway, Pharmacokinetics |
.37
|
|
| 4 | cytochrome P450 |
.71
|
|
| 5 | Phase II conjugation |
Pathways by source for CYP2E1 Gene
11 BioSystems pathways for CYP2E1 Gene
6 Reactome pathways for CYP2E1 Gene
8 KEGG pathways for CYP2E1 Gene
6 GeneGo (Thomson Reuters) pathways for CYP2E1 Gene
1 Qiagen pathway for CYP2E1 Gene
Interacting Proteins for CYP2E1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0010243 | response to organonitrogen compound | IEA | -- |
| GO:0016098 | monoterpenoid metabolic process | IDA | 16401082 |
| GO:0017144 | drug metabolic process | IMP,TAS | -- |
| GO:0018910 | benzene metabolic process | TAS | -- |
| GO:0042493 | response to drug | IEA | -- |
No data available for SIGNOR curated interactions for CYP2E1 Gene
Drugs & Compounds for CYP2E1 Gene
(223) Drugs for CYP2E1 Gene - From: DrugBank, PharmGKB, ClinicalTrials, ApexBio, FDA Approved Drugs, HMDB, and Novoseek
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Chlorzoxazone | Approved | Pharma | Agonist, Activator, Enzyme, substrate, inhibitor | 6 | ||
| Acetaminophen | Approved | Pharma | Enzyme, substrate | 902 | ||
| Ethanol | Approved | Pharma | Enzyme, substrate, inhibitor, inducer | 1924 | ||
| Quinidine | Approved | Pharma | Pore Blocker, Enzyme, substrate | 43 | ||
| Theophylline | Approved | Pharma | Antagonist, Enzyme, substrate | 59 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| nadph |
|
53-57-6 | ||||
| oxygen |
|
7782-44-7 | ||||
| Paraxanthine |
|
611-59-6 | ||||
| 11,12,15-THETA |
|
|
||||
| 11,12-Epoxyeicosatrienoic acid |
|
81276-02-0 |
|
(1) ApexBio Compounds for CYP2E1 Gene
| Compound | Action | Cas Number |
|---|---|---|
| Chlorzoxazone | 95-25-0 |
Drug Products
- ApexBio compounds for CYP2E1
Transcripts for CYP2E1 Gene
mRNA/cDNA for CYP2E1 Gene
- (1) REFSEQ mRNAs :
- (11) Additional mRNA sequences :
- (154) Selected AceView cDNA sequences:
- (10) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for CYP2E1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for CYP2E1
-
Santa Cruz Biotechnology (SCBT) CRISPR for CYP2E1
- GenScript: Design CRISPR guide RNA sequences for CYP2E1
miRNA Products
- Search ViGene Biosciences for CYP2E1
Clone Products
- OriGene clones in human for CYP2E1
- OriGene ORF clones in human,mouse,rat for CYP2E1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for CYP2E1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | ^ | 8 | ^ | 9a | · | 9b | ^ | 10a | · | 10b | ^ | 11a | · | 11b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||||||||||||||||
| SP6: | - | ||||||||||||||||||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||||||||||||||||||
| SP8: |
Expression for CYP2E1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Liver (Hepatobiliary System)
- Mature Hepatocytes Liver Lobule
- Perivenous Hepatocytes Liver Lobule
- Hepatocytes Liver Lobule
- Adipose (Muscoskeletal System)
-
Esophagus (Gastrointestinal Tract)
mRNA differential expression in normal tissues according to GTEx for CYP2E1 Gene
This gene is overexpressed in Liver (x50.7).
This gene is overexpressed in Gallbladder (38.9) and Liver (27.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CYP2E1 Gene
SOURCE GeneReport for Unigene cluster for CYP2E1 Gene Hs.12907
- Elite partner
Primer Products
-
OriGene qPCR primer pairs for CYP2E1
-
OriGene qPCR primer pairs and template standards for CYP2E1
No data available for mRNA Expression by UniProt/SwissProt for CYP2E1 Gene
Orthologs for CYP2E1 Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | CYP2E1 35 |
|
||
| CYP2E1 36 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | CYP2E1 35 |
|
||
| CYP2E1 36 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | Cyp2e1 35 |
|
||
| Cyp2e1 16 |
|
||||
| Cyp2e1 36 |
|
OneToOne | |||
| chimpanzee (Pan troglodytes) |
Mammalia | LOC450857 35 |
|
||
| CYP2E1 36 |
|
OneToOne | |||
| rat (Rattus norvegicus) |
Mammalia | Cyp2e1 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | CYP2E1 36 |
|
OneToOne |
- Species with no ortholog for CYP2E1:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for CYP2E1 Gene
Paralogs for CYP2E1 Gene
(40) SIMAP similar genes for CYP2E1 Gene using alignment to 11 proteins:
- CYP2C19
- CYP 2C
- CYP2C9
- CYP2C8
- CYP2C18
- CYP2G1P
- CYP2A13
- CYP2A6
- CYP2A6V2
- CYP2F1
- CYP2B
- CYP2A7
- CYP2B6
- CYP2B7
- DKFZp686I24235
- CYP2S1
- CYP2R1
- CYP2J2
- CYP2W1
- CYP2U1
- CYP2D6
- CYP21A2
- CYP2D7P1
- CYP1B1
- CYP4V2
- CYP17A1
- CYP1A1
- CYP3A5
- CYP3A4
- CYP26B1
- CYP21
- CYP19A1
- P450-CYP21B
- CYP1A2
- CYP3A43
- CYP3A7
- CYP21A/CYP21B fusion gene
- TBXAS1
- CYP11B1
- CYP4F11
Variants for CYP2E1 Gene
| SNP ID | Clin | Chr 10 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs72559710 | - | 133,528,530(+) | GCAGC(A/C/G)CATGG | reference, missense | |
| rs6413419 | - | 133,532,171(+) | GCAAC(A/G)TCATA | reference, missense | |
| rs55897648 | - | 133,537,760(+) | CAGTC(A/G/T)TAGTG | reference, missense | |
| rs28969387 | - | 133,538,852(+) | GCAGC(A/T)TTTTA | reference, missense | |
| rs41299426 | - | 133,532,698(+) | TTTAC(A/G)ATAAT | reference, missense |
Residual Variation Intolerance Score:
64.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.04;
68.64% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for CYP2E1 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CYP2E1 Gene
Disorders for CYP2E1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| fatty liver disease |
|
|
| alcoholic liver cirrhosis |
|
|
| alcohol abuse |
|
|
| drug-induced hepatitis |
|
|
| alcoholic pancreatitis |
|
Search CYP2E1 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for CYP2E1
No data available for UniProtKB/Swiss-Prot and Genatlas for CYP2E1 Gene
Publications for CYP2E1 Gene
- Genetic polymorphisms of aldehyde dehydrogenase 2, cytochrome p450 2E1 for liver cancer risk in HCV antibody-positive japanese patients and the variations of CYP2E1 mRNA expression levels in the liver due to its polymorphism. (PMID: 12940444) Kato S. … Naito Z. (Scand. J. Gastroenterol. 2003) 3 23 48 67
- Involvement of cytochrome P450 2C9, 2E1 and 3A4 in trimethadione N-demethylation in human microsomes. (PMID: 14651673) Tanaka E. … Yasuhara H. (J Clin Pharm Ther 2003) 23 25 26
- Assessment of specificity of eight chemical inhibitors using cDNA-expressed cytochromes P450. (PMID: 10821163) Sai Y. … Shou M. (Xenobiotica 2000) 23 25 26
- Cytochrome P450 2E1 is the principal catalyst of human oxidative halothane metabolism in vitro. (PMID: 9103523) Spracklin D.K. … Kharasch E.D. (J. Pharmacol. Exp. Ther. 1997) 23 25 26
- Reversible inhibition of four important human liver cytochrome P450 enzymes by diethylstilbestrol. (PMID: 21553654) Qu Y.Q. … Wang L.M. (Pharmazie 2011) 25 26
Products for CYP2E1 Gene
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- OriGene qPCR primer pairs for CYP2E1
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- GenScript: Design CRISPR guide RNA sequences for CYP2E1
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- Novus Biologicals Antibodies for CYP2E1
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- Cloud-Clone Corp. Antibodies for CYP2E1
- Cloud-Clone Corp. Proteins for CYP2E1
- Cloud-Clone Corp Assay Kits for CYP2E1
- Invitrogen Antibodies for CYP2E1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- ApexBio compounds for CYP2E1
- antibodies-online Antibodies for CYP2E1: See all 156
- antibodies-online Kits for CYP2E1: See all 47
- antibodies-online Proteins for CYP2E1: See all 26
- Search antibodies-online for peptides
- GeneTex CYP2E1 antibody for CYP2E1
- Search GeneTex for Proteins for CYP2E1
- ViGene Biosciences adenoviral particle packaged cDNA for CYP2E1 gene
- ViGene Biosciences lentiviral particle packaged cDNA for CYP2E1 gene
- ViGene Biosciences lentiviral particle packaged cDNA for CYP2E1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for CYP2E1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for CYP2E1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for CYP2E1 gene
- Search ViGene Biosciences for CYP2E1
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- Santa Cruz Biotechnology (SCBT) Antibodies for CYP2E1
- Search Santa Cruz Biotechnology (SCBT) for CYP2E1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CYP2E1
Sources for CYP2E1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) I2D
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) RNAdb
- (30) ASD
- (31) ECgene
- (32) GeneAnnot
- (33) SAGE
- (34) SOURCE
- (35) HomoloGene
- (36) PanEnsembl
- (37) euGenes
- (38) SGD
- (39) FlyBase
- (40) WormBase
- (41) Pseudogene
- (42) DGV
- (43) dbSNP
- (44) HapMap
- (45) GenAtlas
- (46) GeneTests
- (47) HGMD
- (48) GAD
- (49) LSDB
- (50) BGMUT
- (51) HuGE
- (52) eBioscience
- (53) Atlas
- (54) Cell Signaling Technology
- (55) GenBank
- (56) H-invDB
- (57) HORDE
- (58) HUGE
- (59) IMGT
- (60) Leiden
- (61) MILLIPORE
- (62) miRBase
- (63) DME
- (64) Nature
- (65) NCBI
- (66) OriGene
- (67) PubMed
- (68) R&D Systems
- (69) Salk
- (70) TGDB
- (71) Tufts
- (72) YEDA
- (73) CROW21
- (74) Tocris
- (75) Abcam
- (76) Novus
- (77) ProSpec
- (78) Sino Biological
- (79) GenScript
- (80) Qiagen
- (81) Cloud-Clone Corp.
- (82) Enzo Life Sciences
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