Aliases for CYP2E1 Gene
Aliases for CYP2E1 Gene
- Cytochrome P450 Family 2 Subfamily E Member 1 2 3 5
- Cytochrome P450, Subfamily IIE (Ethanol-Inducible), Polypeptide 1 2 3
- Cytochrome P450, Family 2, Subfamily E, Polypeptide 1 2 3
- 4-Nitrophenol 2-Hydroxylase 3 4
- Cytochrome P450-J 3 4
- CYPIIE1 3 4
- CYP2E 3 4
- Flavoprotein-Linked Monooxygenase 3
- Microsomal Monooxygenase 3
External Ids for CYP2E1 Gene
- HGNC: 2631
- Entrez Gene: 1571
- Ensembl: ENSG00000130649
- OMIM: 124040
- UniProtKB: P05181
Previous HGNC Symbols for CYP2E1 Gene
- CYP2E
Previous GeneCards Identifiers for CYP2E1 Gene
- GC10P134255
- GC10P134470
- GC10P135256
- GC10P134814
- GC10P135229
- GC10P135352
- GC10P128882
Summaries for CYP2E1 Gene
-
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is induced by ethanol, the diabetic state, and starvation. The enzyme metabolizes both endogenous substrates, such as ethanol, acetone, and acetal, as well as exogenous substrates including benzene, carbon tetrachloride, ethylene glycol, and nitrosamines which are premutagens found in cigarette smoke. Due to its many substrates, this enzyme may be involved in such varied processes as gluconeogenesis, hepatic cirrhosis, diabetes, and cancer. [provided by RefSeq, Jul 2008]
GeneCards Summary for CYP2E1 Gene
CYP2E1 (Cytochrome P450 Family 2 Subfamily E Member 1) is a Protein Coding gene. Diseases associated with CYP2E1 include Alcohol Abuse and Fatty Liver Disease. Among its related pathways are Cytochrome P450 - arranged by substrate type and Phenytoin Pathway, Pharmacokinetics. GO annotations related to this gene include enzyme binding and iron ion binding. An important paralog of this gene is CYP2C9.
UniProtKB/Swiss-Prot for CYP2E1 Gene
-
Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms.
No data available for CIViC summary , Tocris Summary , fRNAdb sequence ontologies and piRNA Summary for CYP2E1 Gene
Genomics for CYP2E1 Gene
Regulatory Elements for CYP2E1 Gene
Enhancers for CYP2E1 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH10G133520 | 1.1 | ENCODE | 11 | -0.1 | -85 | 0.2 | CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF548 SP3 SP5 | ENSG00000235245 CYP2E1 TUBGCP2 LOC105378575 |
| GH10G133318 | 1.3 | Ensembl ENCODE | 5.1 | -201.7 | -201725 | 1.0 | HDGF PKNOX1 AGO1 ARID4B SIN3A GLI4 ZNF2 ZNF48 GLIS2 ZNF143 | CYP2E1 TUBGCP2 GC10M133326 |
| GH10G133516 | 0.4 | FANTOM5 | 13.2 | -3.9 | -3937 | 0.4 | TEAD1 TEAD3 | CYP2E1 SYCE1 LOC105378575 |
| GH10G133529 | 0.8 | FANTOM5 | 4.1 | +8.9 | 8893 | 0.1 | NRF1 MAX UBTF KLF16 NR2C1 MYC WT1 ZBTB20 EZH2 NR2C2 | PRAP1 CYP2E1 FUOM ECHS1 KNDC1 ENSG00000278518 PIR52458 |
| GH10G133474 | 0.2 | ENCODE | 7 | -44.8 | -44822 | 1.5 | SCART1 OR7M1P CYP2E1 LOC105378576 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around CYP2E1 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for CYP2E1 Gene
- Chromosome:
- 10
- Start:
- 133,520,406 bp from pter
- End:
- 133,561,220 bp from pter
- Size:
- 40,815 bases
- Orientation:
- Plus strand
Genomic View for CYP2E1 Gene
Genes around CYP2E1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 10q26.3 by Ensembl
- 10q26.3 by Entrez Gene
- 10q26.3 by HGNC
CYP2E1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CYP2E1 Gene
Proteins for CYP2E1 Gene
-
Protein details for CYP2E1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P05181-CP2E1_HUMAN
- Recommended name:
- Cytochrome P450 2E1
- Protein Accession:
- P05181
- Q5VZD5
- Q6NWT9
- Q9UK47
Protein attributes for CYP2E1 Gene
- Size:
- 493 amino acids
- Molecular mass:
- 56849 Da
- Cofactor:
- Name=heme; Xref=ChEBI:CHEBI:30413;
- Quaternary structure:
- No Data Available
Protein Expression for CYP2E1 Gene
Selected DME Specific Peptides for CYP2E1 Gene
- P05181:
-
- EIDRVIG
- LFFAGTET
- PFSTGKR
- VDPKDID
- GEGLARME
- TTSTTLRY
- AGTETTS
Post-translational modifications for CYP2E1 Gene
Other Protein References for CYP2E1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for CYP2E1
- Novus Biologicals Antibodies for CYP2E1
- Invitrogen Antibodies for CYP2E1
- antibodies-online Antibodies for CYP2E1: See all 156
- GeneTex CYP2E1 antibody for CYP2E1
Protein Products
-
OriGene Purified Proteins for CYP2E1
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-
Cloud-Clone Corp. Proteins for CYP2E1
- antibodies-online Proteins for CYP2E1: See all 26
- Search antibodies-online for peptides
- Search GeneTex for Proteins for CYP2E1
Assay Products
- antibodies-online Kits for CYP2E1: See all 47
Domains & Families for CYP2E1 Gene
Gene Families for CYP2E1 Gene
- HGNC:
- IUPHAR :
Protein Domains for CYP2E1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for CYP2E1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P05181- Family:
-
- Belongs to the cytochrome P450 family.
Function for CYP2E1 Gene
Molecular function for CYP2E1 Gene
- UniProtKB/Swiss-Prot CatalyticActivity:
- 4-nitrophenol + NADPH + O(2) = 4-nitrocatechol + NADP(+) + H(2)O.
- UniProtKB/Swiss-Prot Function:
- Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms.
- UniProtKB/Swiss-Prot Induction:
- By ethanol and isoniazid.
Enzyme Numbers (IUBMB) for CYP2E1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004497 | monooxygenase activity | IDA,TAS | 19651758 |
| GO:0005506 | iron ion binding | IEA | -- |
| GO:0008392 | arachidonic acid epoxygenase activity | IBA | -- |
| GO:0016491 | oxidoreductase activity | IDA | 16401082 |
| GO:0016705 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | IEA | -- |
Phenotypes for CYP2E1 Gene
- MGI mutant phenotypes for CYP2E1:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for CYP2E1:
Animal Models for CYP2E1 Gene
- MGI Knock Outs for CYP2E1:
-
- Cyp2e1 tm1Gonz
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
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-
-
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-
ViGene Biosciences ready-to-package AAV shRNAs for CYP2E1 gene
- Search ViGene Biosciences for CYP2E1
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-
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-
Santa Cruz Biotechnology (SCBT) CRISPR for CYP2E1
- GenScript: Design CRISPR guide RNA sequences for CYP2E1
miRNA for CYP2E1 Gene
- miRTarBase miRNAs that target CYP2E1
miRNA Products
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Inhibitory RNA Products
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
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-
ViGene Biosciences adenoviral particle packaged cDNA for CYP2E1 gene
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-
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No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CYP2E1 Gene
Localization for CYP2E1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CYP2E1 Gene
- Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
| Compartment | Confidence |
|---|---|
| endoplasmic reticulum | 5 |
| mitochondrion | 4 |
| plasma membrane | 2 |
| extracellular | 2 |
| peroxisome | 2 |
| nucleus | 2 |
| cytosol | 2 |
| lysosome | 2 |
| golgi apparatus | 2 |
| cytoskeleton | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000139 | Golgi membrane | IEA | -- |
| GO:0005739 | mitochondrion | IEA | -- |
| GO:0005783 | endoplasmic reticulum | IEA | -- |
| GO:0005789 | endoplasmic reticulum membrane | TAS | -- |
| GO:0016020 | membrane | IEA | -- |
Pathways & Interactions for CYP2E1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Cytochrome P450 - arranged by substrate type |
.39
.01
|
|
| 2 | Drug metabolism - cytochrome P450 | ||
| 3 | Acetaminophen Pathway (therapeutic doses), Pharmacokinetics | ||
| 4 | Caffeine Pathway, Pharmacokinetics | ||
| 5 | Phenytoin Pathway, Pharmacokinetics | ||
Pathways by source for CYP2E1 Gene
14 BioSystems pathways for CYP2E1 Gene
6 Reactome pathways for CYP2E1 Gene
8 KEGG pathways for CYP2E1 Gene
6 GeneGo (Thomson Reuters) pathways for CYP2E1 Gene
1 Qiagen pathway for CYP2E1 Gene
Interacting Proteins for CYP2E1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006641 | triglyceride metabolic process | IEA | -- |
| GO:0006805 | xenobiotic metabolic process | TAS | -- |
| GO:0008202 | steroid metabolic process | IMP | 18356043 |
| GO:0010193 | response to ozone | IEA | -- |
| GO:0010243 | response to organonitrogen compound | IEA | -- |
No data available for SIGNOR curated interactions for CYP2E1 Gene
Drugs & Compounds for CYP2E1 Gene
(232) Drugs for CYP2E1 Gene - From: DrugBank, PharmGKB, ClinicalTrials, ApexBio, FDA Approved Drugs, HMDB, and Novoseek
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Chlorzoxazone | Approved | Pharma | Agonist, Activator, Enzyme, substrate, inhibitor | 7 | ||
| Ethanol | Approved | Pharma | Enzyme, substrate, inhibitor, inducer | 2137 | ||
| Quinidine | Approved | Pharma | Pore Blocker, Enzyme, substrate | 45 | ||
| Sevoflurane | Approved, Vet_approved | Pharma | Enzyme, substrate | 508 | ||
| Theophylline | Approved | Pharma | Antagonist, Enzyme, substrate | 64 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| nadph |
|
53-57-6 | ||||
| Paraxanthine |
|
611-59-6 | ||||
| 11,12,15-THETA |
|
|
||||
| 11,12-Epoxyeicosatrienoic acid |
|
81276-02-0 |
|
|||
| 11,14,15-THETA |
|
|
(2) ApexBio Compounds for CYP2E1 Gene
| Compound | Action | Cas Number |
|---|---|---|
| 3-Cyano-7-ethoxycoumarin | 117620-77-6 | |
| Chlorzoxazone | 95-25-0 |
Transcripts for CYP2E1 Gene
mRNA/cDNA for CYP2E1 Gene
- (1) REFSEQ mRNAs :
- (11) Additional mRNA sequences :
- (154) Selected AceView cDNA sequences:
- (10) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for CYP2E1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for CYP2E1
-
Santa Cruz Biotechnology (SCBT) CRISPR for CYP2E1
- GenScript: Design CRISPR guide RNA sequences for CYP2E1
miRNA Products
- Search ViGene Biosciences for CYP2E1
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CYP2E1
- Browse OriGene Inhibitory RNA Products For CYP2E1
-
ViGene Biosciences ready-to-package AAV shRNAs for CYP2E1 gene
Clone Products
-
OriGene ORF clones in human for CYP2E1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for CYP2E1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CYP2E1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CYP2E1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | ^ | 8 | ^ | 9a | · | 9b | ^ | 10a | · | 10b | ^ | 11a | · | 11b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||||||||||||||||
| SP6: | - | ||||||||||||||||||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||||||||||||||||||
| SP8: |
Expression for CYP2E1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Liver (Hepatobiliary System)
- Mature Hepatocytes Liver Lobule
- Perivenous Hepatocytes Liver Lobule
- Hepatocytes Liver Lobule
- Adipose (Muscoskeletal System)
-
Esophagus (Gastrointestinal Tract)
mRNA differential expression in normal tissues according to GTEx for CYP2E1 Gene
This gene is overexpressed in Liver (x50.7).
This gene is overexpressed in Gallbladder (38.9) and Liver (27.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CYP2E1 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of CYP2E1 Gene:
CYP2E1SOURCE GeneReport for Unigene cluster for CYP2E1 Gene:
Hs.12907Evidence on tissue expression from TISSUES for CYP2E1 Gene
- Liver(5)
- Nervous system(4.6)
- Blood(2.5)
- Lung(2.4)
- Kidney(2.3)
- Urine(2.2)
- Intestine(2)
Primer Products
-
OriGene qPCR primer pairs and template standards for CYP2E1
-
OriGene qPCR primer pairs for CYP2E1
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CYP2E1 Gene
Orthologs for CYP2E1 Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | LOC450857 34 |
|
||
| CYP2E1 35 |
|
OneToOne | |||
| cow (Bos Taurus) |
Mammalia | CYP2E1 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Cyp2e1 34 |
|
||
| dog (Canis familiaris) |
Mammalia | CYP2E1 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Cyp2e1 34 16 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | CYP2E1 35 |
|
OneToOne |
- Species where no ortholog for CYP2E1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for CYP2E1 Gene
Paralogs for CYP2E1 Gene
(40) SIMAP similar genes for CYP2E1 Gene using alignment to 11 proteins:
- CYP2C19
- CYP 2C
- CYP2C9
- CYP2C8
- CYP2C18
- CYP2G1P
- CYP2A13
- CYP2A6
- CYP2A6V2
- CYP2F1
- CYP2B
- CYP2A7
- CYP2B6
- CYP2B7
- DKFZp686I24235
- CYP2S1
- CYP2R1
- CYP2J2
- CYP2W1
- CYP2U1
- CYP2D6
- CYP21A2
- CYP2D7P1
- CYP1B1
- CYP4V2
- CYP17A1
- CYP1A1
- CYP3A5
- CYP3A4
- CYP26B1
- CYP21
- CYP19A1
- P450-CYP21B
- CYP1A2
- CYP3A43
- CYP3A7
- CYP21A/CYP21B fusion gene
- TBXAS1
- CYP11B1
- CYP4F11
Variants for CYP2E1 Gene
| SNP ID | Clin | Chr 10 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs2031920 | other | 133,526,341(+) | AAGTA(C/T)AAAAT | nc-transcript-variant, upstream-variant-2KB | |
| rs3813867 | other | 133,526,101(+) | GAGAG(C/G)TGCAG | nc-transcript-variant, upstream-variant-2KB | |
| rs6413432 | other | 133,535,040(+) | AAATT(A/T)AAAAA | intron-variant | |
| rs1000422283 | -- | 133,538,612(+) | TTCCA(C/T)TCAAG | intron-variant | |
| rs1000612057 | -- | 133,533,386(+) | CTGAG(A/C)ATCTT | intron-variant |
Residual Variation Intolerance Score:
64.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.04;
68.64% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for CYP2E1 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CYP2E1 Gene
Disorders for CYP2E1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| alcohol abuse |
|
|
| fatty liver disease |
|
|
| alcoholic liver cirrhosis |
|
|
| drug-induced hepatitis |
|
|
| isoniazid toxicity |
|
|
Search CYP2E1 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for CYP2E1
No data available for UniProtKB/Swiss-Prot and Genatlas for CYP2E1 Gene
Publications for CYP2E1 Gene
- Cytochrome P450 2E1 gene polymorphisms/haplotypes and Parkinson's disease in a Swedish population. (PMID: 19381774) Shahabi H.N. … Nissbrandt H. (J Neural Transm 2009) 3 22 46 64
- Effect of combined genetic polymorphisms on lung cancer risk in northern Thai women. (PMID: 19963114) Klinchid J. … Cressey R. (Cancer Genet. Cytogenet. 2009) 3 22 46 64
- Genetic variations of NAT2 and CYP2E1 and isoniazid hepatotoxicity in a diverse population. (PMID: 19761367) Yamada S. … Marra F. (Pharmacogenomics 2009) 3 22 46 64
- Polymorphism in cytochrome P450 2E1 and interaction with other genetic risk factors and susceptibility to alcoholic liver cirrhosis. (PMID: 19428381) Khan A.J. … Parmar D. (Mutat. Res. 2009) 3 22 46 64
- Comparison of genetic polymorphisms of CYP2E1, ADH2, and ALDH2 genes involved in alcohol metabolism in Koreans and four other ethnic groups. (PMID: 19250143) Kang T.S. … Roh J. (J Clin Pharm Ther 2009) 3 22 46 64
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- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for CYP2E1
- Novus Biologicals proteins and lysates for CYP2E1
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- ProSpec Recombinant Proteins for CYP2E1
- Browse Antibodies at Cloud-Clone Corp.
- Cloud-Clone Corp. Proteins for CYP2E1
- Browse Assay Kits at Cloud-Clone Corp.
- Invitrogen Antibodies for CYP2E1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- ApexBio compounds for CYP2E1
- antibodies-online Antibodies for CYP2E1: See all 156
- antibodies-online Kits for CYP2E1: See all 47
- antibodies-online Proteins for CYP2E1: See all 26
- Search antibodies-online for peptides
- GeneTex CYP2E1 antibody for CYP2E1
- Search GeneTex for Proteins for CYP2E1
- ViGene Biosciences adenoviral particle packaged cDNA for CYP2E1 gene
- ViGene Biosciences lentiviral particle packaged cDNA for CYP2E1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for CYP2E1 gene
- Search ViGene Biosciences for CYP2E1
- Horizon Cell Lines for CYP2E1
- Cyagen custom Knockout/knockin (KOKI) mouse models for CYP2E1
- VectorBuilder custom plasmid, inducible vectors for CYP2E1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CYP2E1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for CYP2E1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer