V3 here soon-try beta now


Gene Search (GeneCards Home)	\|	GeneCards Guide	\|	User Feedback	\|	Terms of Use	\|	Notice about third-party sites

CYP2E1 Gene

protein-coding GIFtS: 69

GC10P135229

cytochrome P450, family 2, subfamily E, polypeptide 1
(Previous names: cytochrome P450, subfamily IIE (ethanol-inducible), polypeptide 1 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: CYP2E)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
CPE1 ^²
CYP2E ^², ³, ⁵
CYPIIE1 ^³
EC 1.14.13.-,EC 1.14.13.n7 ^³
OTTHUMP00000020813 ^²
OTTHUMP00000046571 ^²
P450-J ^², ³
P450C2E ^², ⁵

Descriptions
4-nitrophenol 2-hydroxylase ^³
cytochrome P450 2E1 ^²
cytochrome P450, family 2, subfamily E, polypeptide 1 ^²
cytochrome P450, subfamily IIE (ethanol-inducible), polypeptide 1 ^¹, ²
flavoprotein-linked monooxygenase ^²
microsomal monooxygenase ^²
xenobiotic monooxygenase ^²

External Ids
HGNC: 2631¹
Entrez Gene: 1571²
UniProtKB: P05181³
Ensembl: ENSG00000130649⁷

Search outside databases for aliases for CYP2E1 gene

Previous GC identifers: GC10P134255 GC10P134470 GC10P135256 GC10P134814

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for CYP2E1:

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450

proteins are monooxygenases which catalyze many reactions involved in drug metabolism and

synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic

reticulum and is induced by ethanol, the diabetic state, and starvation. The enzyme metabolizes

both endogenous substrates, such as ethanol, acetone, and acetal, as well as exogenous substrates

including benzene, carbon tetrachloride, ethylene glycol, and nitrosamines which are premutagens

found in cigarette smoke. Due to its many substrates, this enzyme may be involved in such varied

processes as gluconeogenesis, hepatic cirrhosis, diabetes, and cancer. [provided by RefSeq]

UniProtKB/Swiss-Prot: CP2E1_HUMAN, P05181

Function: Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites.

Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to

their hepatotoxic or carcinogenic forms

Gene Wiki entry for CYP2E1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the CYP2E1 gene

Entrez Gene cytogenetic band: 10q24.3-qter Ensembl cytogenetic band: 10q26.3 HGNC chromosome: 10

CYP2E1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10P135229: (about GC identifiers)

Start:	135,190,857 bp from pter
End:	135,224,714 bp from pter
Size:	33,858 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000010.9 NT_017795.18

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: CP2E1_HUMAN, P05181 (See protein sequence)

Recommended Name: Cytochrome P450 2E1

Size: 493 amino acids; 56849 Da

Cofactor: Heme group (By similarity)

Subcellular location: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome

membrane; Peripheral membrane protein

PDB structure from and Proteopedia :

3E4E (3D)

3E6I (3D)

Secondary accessions: Q5VZD5 Q9UK47

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_000764.1

ENSEMBL proteins:

ENSP00000252945 ENSP00000357506

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Sigma-Aldrich AQUA Peptides for CYP2E1
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Cytochrome P450 2E1)
	Human Recombinant Proteins from Abnova (CYP2E1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005783	endoplasmic reticulum	IEA	--
GO:0005789	endoplasmic reticulum membrane	IEA	--
GO:0005792	microsome	IEA	--
GO:0016020	membrane	IEA	--

About this table

Antibodies for CYP2E1:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of CYP2E1
	Sigma-Aldrich Antibodies for CYP2E1
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (Cytochrome P450 2E1), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (CYP2E1)
	Novus Biologicals Antibodies for CYP2E1

Assays for CYP2E1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P05181

ProtoNet protein and cluster: P05181

2 Blocks protein families:

IPB002401 E-class P450 group I signature

IPB008070 CYP2E P450 family signature

UniProtKB/Swiss-Prot: CP2E1_HUMAN, P05181

Similarity: Belongs to the cytochrome P450 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CYP2E1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CYP2E1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000773

Applied Biosystems Silencer® siRNAs for CYP2E1

Sigma-Aldrich siRNA and siRNA Panels for CYP2E1

Sigma-Aldrich shRNA for CYP2E1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for CYP2E1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_000773
Myc/DDK tagged cDNA clone in CMV expression vector: NM_000773
untagged cDNA clone in CMV expression vector: NM_000773

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000773

UniProtKB/Swiss-Prot: CP2E1_HUMAN, P05181

Function: Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites.

Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to

their hepatotoxic or carcinogenic forms

Catalytic activity: 4-nitrophenol + NADPH + O(2) = 4-nitrocatechol + NADP(+) + H(2)O

Induction: By ethanol and isoniazid

Enzyme Number (IUBMB): EC 1.14.13.-,EC

5 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Cyp2e1):

homeostasis/metabolism

life span-post-weaning/aging

liver/biliary system

tumorigenesis

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0009055	electron carrier activity	IEA	--
GO:0019825	oxygen binding	TAS	3233219
GO:0020037	heme binding	IEA	--
GO:0046872	metal ion binding	IEA	--
GO:0070330	aromatase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/6 Sigma-Aldrich "Your Favorite Gene" Pathways for CYP2E1 (Your Favorite Gene powered by Ingenuity) (see all 6 )

Arachidonic Acid Metabolism
Metabolism of Xenobiotics by Cytochrome P450
Fatty Acid Metabolism
Hepatic Fibrosis / Hepatic Stellate Cell Activation
Linoleic Acid Metabolism

GeneDecks CYP2E1 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for CYP2E1

5/114 Interacting proteins for CYP2E1 (ENSP00000252945³) via UniProtKB, MINT, and/or STRING (see all 114 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ADH1B	ENSP00000306606³	STRING (score=.987)
ADHFE1	ENSP00000276576³	STRING (score=.985)
PTGS2	ENSP00000356438³	STRING (score=.98)
ALDH2	ENSP00000261733³	STRING (score=.977)
EPHX1	ENSP00000355802³	STRING (score=.975)

About this table

1 Gene Ontology (GO) biological process term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0055114	oxidation reduction	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for CYP2E1

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for CYP2E1
10/63 Novoseek chemical compound relationships for CYP2E1 gene (see all 63 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
6-hydroxychlorzoxazone	91.97	22	10490907 (2), 12585472 (2), 17119944 (1), 9322481 (1) (see all 16)
rsai	88.36	52	8547826 (4), 7534543 (4), 9825833 (3), 8977352 (2) (see all 32)
dimethylnitrosamine	81.69	23	8622629 (1), 9675256 (1), 17567472 (1), 18378564 (1) (see all 20)
p-nitrophenol	80.95	40	15135088 (4), 17584020 (2), 14669323 (2), 14556645 (2) (see all 26)
nitrosamines	75.22	28	15242818 (4), 17146594 (2), 9806171 (2), 18818195 (1) (see all 17)
chlorodifluoroacetic acid	75.20	2	12451447 (1)
epoxide	75.05	30	8232220 (2), 16039674 (2), 8377657 (1), 8236284 (1) (see all 26)
ethanol	73.69	300	10029205 (6), 11602665 (5), 8632758 (5), 17284772 (5) (see all 99)
glycidamide	72.05	9	19131562 (1), 17088317 (1), 18624445 (1), 16337756 (1)
7-ethoxy-4-trifluoromethylcoumarin	71.30	9	12490624 (3), 15205384 (1), 15829437 (1), 9241656 (1)

About this table

9 PharmGKB drug compound relationships for CYP2E1 gene

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
alcohol	PD PK GN	11701642
dexamethasone	PK FA	8114683
ethanol	PD FA GN	9114822 9731720 9194910
etoposide	PK FA	8114683
midazolam	PK FA	8114683
nicotine	CO PK GN	12777962
teniposide	PK FA	8114683
thiotepa	PK	11950782
xenobiotics	PD PK FA GN	9918138 8807659 12367788 9114822

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CYP2E1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CYP2E1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000773

Sigma-Aldrich siRNA and siRNA Panels for CYP2E1

Sigma-Aldrich shRNA for CYP2E1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000773

REFSEQ mRNAs for CYP2E1 gene:

NM_000773.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000773

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000773
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000773
                                 untagged cDNA clone in CMV expression vector: NM_000773

Additional cDNA sequence:

AF084225.1 AF182276.1 AJ853939.1 AJ853940.1 AJ877238.1 AK290822.1 BC067433.1 BC067435.1

CR592801.1 CR603555.1 CR618024.1 CR621945.1 CR622294.1 CR626742.1 CR626746.1 DQ149222.1

J02625.1 S77873.1

14 DOTS entries:

DT.444621 DT.99987835 DT.92449334 DT.121278796 DT.91699780 DT.92449330 DT.100772634 DT.100798406

DT.40296356 DT.40227062 DT.92449335 DT.100798402 DT.100798404 DT.92449336

24/154 AceView cDNA sequences (see all 154 ):

AV697094 CR618024 CR603555 CR626746 AL531476 CR621945 AL558632 CB124845

CA311379 CR592801 BQ879759 BX449120 CB154278 T64762 CR622294 BX951454

CR626742 BM547116 CB147267 BG567046 AA423809 AF182276 AL532016 BG545098

highest scoring ESTs for CYP2E1:

J02625 AF084225 AF182276 AL532015 AL532220 AL564269 AL564573 AL580410 AV682019 AV718404

Unigene Cluster for CYP2E1:

Cytochrome P450, family 2, subfamily E, polypeptide 1

Hs.12907 [show with all ESTs]

Unigene Representative Sequence: NM_000773

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for CYP2E1 (see all 8 )

ExUns:	1	^	2	^	3a	·	3b	·	3c	^	4a	·	4b	^	5a	·	5b	^	6a	·	6b	^	7a	·	7b	·	7c	^	8	^	9a	·	9b	^	10a	·	10b	^	11a	·	11b
SP1:															-				-												-
SP2:											-		-		-				-												-
SP3:											-		-		-		-		-												-
SP4:											-		-		-				-		-		-						-		-
SP5:

About this scheme

ECgene alternative splicing isoforms for CYP2E1

2 Ensembl transcripts including schematic representations:

ENST00000252945 ENST00000368520

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

CYP2E1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for CYP2E1

¹ / ² / ³

9 probe-sets matching CYP2E1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
1431_at²^{, 3}	U133-A	1	1.00	1.00	0.99	0.91	J02843	0.20	1.00	0.72	1
40379_at²^{, 3}	U95-A	1	1.00	1.00	0.98	1.01	J02625	1.00	1.00	1.00	1
75592_at*²^{, 3}	U95-D	1	--	--	0.45	1.11	H17530	0.20	1.00	0.72	1
209975_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AF182276	0.80	1.00	0.91	1
209976_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AF182276	0.80	1.00	0.91	1
1431_at²^{, 3}	U133-A	1	1.00	1.00	--	--	J02843	0.20	1.00	0.72	1
209975_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
209976_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1431_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks CYP2E1 for binary patterns associated with the probe-sets selected above

About GeneDecksing

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: AGTGTGTGGA

SOURCE GeneReport for Unigene cluster: Hs.12907
Expression variation in blood from EXPOLDB for CYP2E1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for CYP2E1 gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	CYP2E1¹	--	cytochrome P450 2E1	79.99(n) 77.28(a)	415128 NM_001003339.1 NP_001003339.1
chimpanzee (Pan troglodytes)	LOC450857¹	--	similar to Cytochrome P450 2E1 (CYPIIE1) (P450-J)	96.08(n) 94.32(a)	450857 XM_508139.2 XP_508139.2
cow (Bos taurus)	CYP2E1¹	--	cytochrome P450 subfamily IIE polypeptide 1	80.73(n) 77.89(a)	282213 NM_174530.2 NP_776955.2
rat (Rattus norvegicus)	Cyp2e1¹	--	cytochrome P450, family 2, subfamily e, polypeptide more	80.05(n) 78.7(a)	25086 NM_031543.1 NP_113731.1
mouse (Mus musculus)	Cyp2e1^{1, 5}	7 (68.40 cM)⁵	cytochrome P450, family 2, subfamily e, polypeptide more^{1, 5}	79.45(n)¹ 78.09(a)¹	13106¹ NM_021282.2¹ NP_067257.1¹ AI323829⁵ BC013451⁵ (see all 13)

About this table Species with no ortholog for CYP2E1

ENSEMBL Gene Tree for CYP2E1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for CYP2E1 gene

CYP2C8² CYP2C9² CYP2C19² CYP2C18²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/207 NCBI SNPs in CYP2E1 are shown (see all 207 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 129)

AB	SNP ID	Valid	Chr 10 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
--	rs2031920^1,2	A,C,F,H	135189835(+)	`AAGTAC/TAAAAT`	1	--	ng5¹		18	NS EU EA WA MN CSAM NA	1242
	rs7081484^1,2	A,C,F,H	135202480(+)	`CTGAAC/TCCCCC`	1	--	ut3¹		12	EU EA WA NA NS	728
	rs2070673^1,2	A,C,F,H	135190557(+)	`GCAGGA/TCGGTA`	1	--	ng5¹		18	MN CSAM EA NA EU WA	1670
	rs6413419^1,2	A,C,F,H	135195665(+)	`GCAACG/ATCATA`	1	I/V	mis¹ ese³		15	MN CSAM EA EU NA WA	1254
	rs3813865^1,2	A,C,F,H	135189234(+)	`GCCAAG/CGCTTC`	1	--	ng5¹		14	EA NA EU WA NS	2108
--	rs2480256^1,2	A,C,F,H	135202504(-)	`CAATTC/TGAAAA`	1	--	ut3¹		7	EA NS	356
	rs2515644^1,2	A,C,F,H	135203069(+)	`CACACC/AACTTC`	1	--	ng3¹		7	EU EA WA NA	562
	rs2070672^1,2	C,F,H	135190538(+)	`GTCTAA/GCCAGT`	1	--	ng5¹		14	MN CSAM EA EU WA NA	1316
	rs2480257^1,2	A,C,F	135202499(-)	`TGAAAT/ACTTGT`	1	--	ut3¹		5	NS	190
	rs6413420^1,2	C,F,H	135190819(+)	`TCTCAG/TAACAC`	1	--	ng5¹		17	MN CSAM EA NA EU WA NS	1144

About this table

HapMap Linkage Disequilibrium images for CYP2E1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 124040

10/83 Novoseek disease relationships for CYP2E1 gene (see all 83 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
liver diseases alcoholic	76.11	40	9453426 (7), 11410736 (4), 19157621 (4), 9731720 (3) (see all 15)
hepatitis halothane	66.70	7	8794896 (4), 8902272 (2)
fatty liver alcoholic	56.16	2	15670659 (1), 14606109 (1)
liver diseases	55.45	36	12883487 (2), 12743671 (2), 11748356 (2), 16380384 (2) (see all 23)
genetic susceptibility	55.26	6	11751440 (1), 9829710 (1), 15138035 (1), 16324524 (1) (see all 6)
alcoholic cirrhosis	54.29	16	19428381 (2), 11748356 (2), 9660317 (1), 14720455 (1) (see all 8)
alcoholism	53.89	27	7573775 (3), 9660317 (2), 15902904 (2), 9695719 (2) (see all 12)
liver damage	52.36	13	15554233 (2), 9453426 (2), 9248625 (1), 15036355 (1) (see all 8)
fatty liver	51.73	11	14606109 (3), 12883487 (1), 15554233 (1), 16321567 (1) (see all 5)
cancer lung	46.55	49	9029171 (4), 7534543 (4), 10209943 (3), 18798003 (3) (see all 26)

About this table

3 PharmGKB disease relationships for CYP2E1 gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Liver Diseases, Alcoholic	PD GN	9731720 9194910
Lung Neoplasms	FA GN	12367788
nicotine dependency	CO PK GN	12777962

About this table

Human Gene Mutation Database: CYP2E1
Genetic Association Database: CYP2E1
Human Genome Epidemiology Navigator: CYP2E1 (281 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/968 PubMed articles for CYP2E1 gene (see all 968 ):

Detection and characterization of novel polymorphisms in the CYP2E1 gene. (PubMed id 9918138)^{3, 4, 7} Fairbrother K.S.... Daly A.K. (1998)
Genetic polymorphisms of aldehyde dehydrogenase 2, cytochrome p450 2E1 for liver cancer risk in HCV antibody-positive japanese patients and the variations of CYP2E1 mRNA expression levels in the liver due to its polymorphism. (PubMed id 12940444)^{1, 3, 6} Kato S....Naito Z. (2003)
[Associations of Rsa I polymorphism at the 5' flanking region of CYP2E1 and PON2 148 polymorphism in neonates with preterm delivery] (PubMed id 12939804)^{1, 3, 6} Wu B.Y....Xu X.P. (2003)
[Association of CYP2E1 of PON2311 polymorphisms in neonates with preterm] (PubMed id 12561466)^{1, 3, 6} Liang H.Y....Xu X.P. (2002)
ALDH2 and CYP2E1 genotypes, urinary acetaldehyde excretion and the health consequences in moderate alcohol consumers. (PubMed id 16365683)^{1, 3, 6} Yamada Y....Honda R. (2006)
A polymorphism in the 5'-flanking region of the CYP2E1 gene and elevated lung adenocarcinoma risk in a Japanese population. (PubMed id 16142352)^{1, 3, 6} Iizasa T....Fujisawa T. (2005)
Effects of dietary intake and genetic factors on hypermethylation of the hMLH1 gene promoter in gastric cancer. (PubMed id 15991278)^{1, 3, 6} Nan H.M....Kim H. (2005)
Effects of genetic polymorphisms in metabolic enzymes on the relationships between 8-hydroxydeoxyguanosine levels in human leukocytes and urinary 1-hydroxypyrene and 2-naphthol concentrations. (PubMed id 14646291)^{1, 3, 6} Kim Y.D....Kim H. (2003)
Role of epoxide hydrolase, NAD(P)H:quinone oxidoreductase, cytochrome P450 2E1 or alcohol dehydrogenase genotypes in susceptibility to colorectal cancer. (PubMed id 16039674)^{1, 3, 6} van der Logt E.M....Peters W.H. (2006)
Genetic polymorphisms in the cytochromes P-450 (1A1, 2E1), microsomal epoxide hydrolase and glutathione S-transferase M1, T1, and P1 genes, and their relationship with chronic bronchitis and relapsing pneumonia in children. (PubMed id 15928955)^{1, 3, 6} Korytina G.F....Victorova T.V. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 1571	HGNC: 2631	AceView: CYP2E1	Ensembl:ENSG00000130649	euGenes: HUgn1571
ECgene: CYP2E1	H-InvDB: CYP2E1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for CYP2E1	Genetics and Cytogenetics in Oncology and Haematology
Cytochrome P450 Allele Nomenclature Committee	http://www.cypalleles.ki.se/cyp2e1.htm
Wikipedia	http://en.wikipedia.org/wiki/CYP2E1
NIEHS-SNPs	http://egp.gs.washington.edu/data/cyp2e1/

Licensable Technologies for CYP2E1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for CYP2E1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for CYP2E1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for CYP2E1		Antibodies for CYP2E1
	Explore super-pooled esiRNAs		Proteins for CYP2E1
	Lentivirus-delivered shRNAs for CYP2E1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (CYP2E1)
	Antibodies (CYP2E1)
	Chimera RNAi (CYP2E1)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (Cytochrome P450 2E1)
	Antibodies (Cytochrome P450 2E1)

Search OriGene for CYP2E1

Search Tocris compounds for CYP2E1

	Drugs for CYP2E1
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for CYP2E1

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
CYP2E1 Gene at Home site.
Version 2.41.1
server5.xennexinc.com

CYP2E1 Gene

protein-coding GIFtS: 69

Aliases &
Descriptions
for CYP2E1

Summaries
for CYP2E1

Genomic Location
for CYP2E1

Proteins
for CYP2E1

Protein Domains/
Families
for CYP2E1

Gene Function
for CYP2E1

Pathways & Interactions
for CYP2E1

Drugs & Compounds
for CYP2E1

Transcripts
for CYP2E1

Expression
for CYP2E1

Orthologs
for CYP2E1

Paralogs
for CYP2E1

SNPs/Variants
for CYP2E1

Disorders & Mutations
for CYP2E1

Medical News
for CYP2E1

Publications
for CYP2E1

Search for CYP2E1

Genome Databases showing CYP2E1

Other Databases showing CYP2E1

Specialized Databases showing CYP2E1

Licensable Technologies
for CYP2E1

Services
for CYP2E1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

CYP2E1 Gene

protein-coding GIFtS: 69

Aliases & Descriptionsfor CYP2E1

Summariesfor CYP2E1

Genomic Locationfor CYP2E1

Proteinsfor CYP2E1

Protein Domains/Familiesfor CYP2E1

Gene Functionfor CYP2E1

Pathways & Interactionsfor CYP2E1

Drugs & Compoundsfor CYP2E1

Transcriptsfor CYP2E1

Expression for CYP2E1

Orthologsfor CYP2E1

Paralogsfor CYP2E1

SNPs/Variantsfor CYP2E1

Disorders & Mutationsfor CYP2E1

Medical Newsfor CYP2E1

Publicationsfor CYP2E1

Search for CYP2E1

Genome Databases showing CYP2E1

Other Databases showing CYP2E1

Specialized Databases showing CYP2E1

Licensable Technologiesfor CYP2E1

Servicesfor CYP2E1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for CYP2E1

Summaries
for CYP2E1

Genomic Location
for CYP2E1

Proteins
for CYP2E1

Protein Domains/
Families
for CYP2E1

Gene Function
for CYP2E1

Pathways & Interactions
for CYP2E1

Drugs & Compounds
for CYP2E1

Transcripts
for CYP2E1

Expression
for CYP2E1

Orthologs
for CYP2E1

Paralogs
for CYP2E1

SNPs/Variants
for CYP2E1

Disorders & Mutations
for CYP2E1

Medical News
for CYP2E1

Publications
for CYP2E1

Licensable Technologies
for CYP2E1

Services
for CYP2E1