CYP2D7P1 Gene
pseudogene GIFtS: 36
GCID: GC22M042536
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cytochrome P450, family 2, subfamily D, polypeptide 7 pseudogene...(Previous names: cytochrome P450, subfamily IID (debrisoquine, sparteine,...)
(Previous symbols: CYP2D, CYP2D@)
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Aliases
for CYP2D7P1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA
Quality score for the ORGUL clustered with this gene is 3
| Aliases |
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| Cytochrome P450, Family 2, Subfamily D, Polypeptide 7 Pseudogene 11 2 | | Cytochrome P450, Subfamily IID (Debrisoquine, Sparteine, Etc., -Metabolizing)Cluster1 | | CYP2D1 2 | | CYP2D7AP2 | | CYP2D71 2 | | P450C2D2 | | CYP2D@1 2 | | P450DB12 |
| External Ids: | HGNC: 26241 | Entrez Gene: 15642 | Ensembl: ENSG000002057027 | UniProtKB: F5H6E74 | UniProtKB: I3L3K64 |
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| | ORGUL members: | |
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| NONCODE:n405523 | |
Export aliases for CYP2D7P1 gene to outside databasesPrevious GC identifers: GC22U990010 GC22M040847 GC22M040860 GC22M040866 GC22M025502
Summaries
for CYP2D7P1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CYP2D7P1:
This pseudogene is a member of the cytochrome P450 gene superfamily. The cytochrome P450 proteins are monooxygenaseswhich catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. Itis possible that, in rare cases, a combination of two SNPs in this gene may result in an open reading frame encoding afunctional enzyme which metabolizes codeine to morphine. This locus is part of a cluster of cytochrome P450 genes onchromosome 22q13.1. (provided by RefSeq, Jul 2008)
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Genomic Views
for CYP2D7P1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CYP2D7P1 gene promoter:
AML1a GATA-3 CP2 MAZR POU3F1 IRF-1 NF-kappaB1
Other transcription factors
Search SABiosciences Chromatin IP Primers for CYP2D7P1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CYP2D7P1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 22q13 Ensembl cytogenetic band: 22q13.2 HGNC cytogenetic band: 22q13.2CYP2D7P1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 22 GeneLoc Exon Structure GeneLoc location for GC22M042536: view genomic region
(about GC identifiers)
Start:
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42,536,214 bp from pter |
End:
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42,540,576 bp from pter |
Size:
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4,363 bases |
Orientation:
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minus strand |
1 alternative location:
| Chr22-,PATCHES 42,530,104-42,534,475 |
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Proteins
for CYP2D7P1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
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UniProtKB/TrEMBL: F5H6E7 (See
protein sequence)Recommended Name: Protein CYP2D7P1 Size: 151 amino acids; 17003 Da
Caution: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered aspreliminary dataUniProtKB/TrEMBL: I3L3K6 (See
protein sequence) Recommended Name: Protein CYP2D7P1 Size: 151 amino acids; 16962 Da
Caution: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered aspreliminary dataCYP2D7P1 Protein expression data from MOPED and PaxDb: --
ENSEMBL proteins: ENSP00000437680 ENSP00000445124 ENSP00000439604
Human Recombinant Protein Products:
CYP2D7P1 Antibody Products:
Assay Products for CYP2D7P1: |
Protein
Domains /
Families
for CYP2D7P1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
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CYP2D7P1 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry F5H6E7Graphical View of Domain Structure for InterPro Entry I3L3K6ProtoNet protein and cluster: F5H6E7 UniProtKB/TrEMBL: F5H6E7 Similarity: Belongs to the cytochrome P450 familyUniProtKB/TrEMBL: I3L3K6 Similarity: Belongs to the cytochrome P450 family |
Function
for CYP2D7P1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYP2D7P1 |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0004497 | monooxygenase activity |
-- | -- | | GO:0009055 | electron carrier activity |
-- | -- | | GO:0016705 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
-- | -- | | GO:0020037 | heme binding |
-- | -- |
CYP2D7P1 for ontologies About GeneDecksing
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Pathways & Interactions
for CYP2D7P1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Unified GeneCards pathways About this table 
See pathways by source
| Super-pathway | contained gene-specific pathways |
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| 1 | Codeine and morphine metabolism | |
1  PharmGKB Pathway for CYP2D7P1
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CYP2D7P1
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Drugs & Compounds
for CYP2D7P1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CYP2D7P1
Search CenterWatch for drugs/clinical trials and news about CYP2D7P1
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Transcripts
for CYP2D7P1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
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5 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000435101 ENST00000358097(uc010gyv.3 uc021wqk.1) ENST00000433992(uc003bcg.3 uc003bci.3 uc010gyw.3 uc010gyx.1)
ENST00000424775 ENST00000435688
24/107 AceView cDNA sequences (see all 107): NM_000106 BC067432 CB144729 BC066877 CB122244 CR456430 AI581683 CB134922 AV645915 CB137789 CK130223 CR614586 CK032846 CB148831 M20403 CD607605 CF271949 CB121435 CK130220 BG775066 CB135649 CK130221 AV684718 CB135746
GeneLoc Exon Structure
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Expression
for CYP2D7P1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CYP2D7P1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAGCTCTTCC
About this image SABiosciences Custom PCR Arrays for CYP2D7P1
Primer
Products: |  | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat CYP2D7P1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CYP2D7P1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CYP2D7P1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYP2D7P1 |
Orthologs
for CYP2D7P1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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--
ENSEMBL Gene Tree for CYP2D7P1 (if available)
TreeFam Gene Tree for CYP2D7P1 (if available) |
Paralogs
for CYP2D7P1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CYP2D7P1 gene
18/27 SIMAP similar genes for CYP2D7P1 using alignment to 3 protein entries: F5H6E7_HUMAN (see all proteins)
(see all similar genes):CYP2D6 CYP2G1P CYP2U1 CYP2R1 CYP2C9 CYP2S1
CYP2E1 CYP 2C CYP2B6 DKFZp686I24235 CYP2A6 CYP1B1
CYP21A2 CYP2J2 CYP2A7 CYP2A13 CYP2F1 CYP2A6V2
CYP2D7P1 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for CYP2D7P1
PGOHUM00000259709
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Genomic Variants
for CYP2D7P1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
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| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 22 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CYP2D7P1 (42536214 - 42540576 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for CYP2D7P1
5 CNVs: 36034 7350 73828 73826 73829
Human Gene Mutation Database (HGMD): CYP2D7P1
| SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for CYP2D7P1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
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CYP2D7P1 for disorders About GeneDecksing
20/23  diseases for CYP2D7P1 (see all 23): About MalaCardsantley-bixler syndrome human immunodeficiency virus infectious disease cholesterol urinary bladder cancer
toxic encephalopathy fascioliasis porphyria aspergillosis
constipation candidiasis autoimmune hepatitis hepatitis c
skin disease cholestasis hypercholesterolemia diarrhea
parkinson's disease hepatocellular carcinoma hepatitis tuberculosis
9 diseases from the University of Copenhagen DISEASES database for CYP2D7P1:Autoimmune hepatitis Breast cancer Schizophrenia Parkinson's disease
Neuroleptic malignant syndrome Pain agnosia Lung cancer Liver disease
Schizoaffective disorder Genetic Association Database (GAD): CYP2D7P1
Human Genome Epidemiology (HuGE) Navigator: CYP2D7P1 (2 documents)
Export disorders for CYP2D7P1 gene to outside databases
|
Publications
for CYP2D7P1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CYP2D7P1 gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with CYP2D7P1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Frequency of the frame-shifting CYP2D7 138delT polymorphism in a large, ethnically diverse sample population. (PubMed id 17494644)1 Bhathena A....Katz D.A. (2007)
- Single-Nucleotide Polymorphisms in NAGNAG Acceptors Are Highly Predictive for Variations of Alternative Splicing. (PubMed id 16400609)1 Hiller M.... Platzer M. (2006)
- CYP2D7 splice variants in human liver and brain: does CYP2D7 encode functional protein? (PubMed id 16169517)1 Gaedigk A....Leeder J.S. (2005)
- A frameshift mutation and alternate splicing in human brain generate a functional form of the pseudogene cytochrome P4502D7 that demethylates codeine to morphine. (PubMed id 15051713)1 Pai H.V....Ravindranath V. (2004)
- Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants. (PubMed id 15128046)1 Nelson D.R....Nebert D.W. (2004)
- Polymorphism of metabolic genes and susceptibility to occupational chronic manganism. (PubMed id 12171760)1 Zheng Y.X....He F.S. (2002)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Evolution of a highly polymorphic human cytochrome P450 gene cluster: CYP2D6. (PubMed id 1358797)1 Heim M.H. and Meyer U.A. (1992)
- The human debrisoquine 4-hydroxylase (CYP2D) locus: sequence and identification of the polymorphic CYP2D6 gene, a related gene, and a pseudogene. (PubMed id 2574001)1 Kimura S.... Gonzalez F.J. (1989)
- Two mutant alleles of the human cytochrome P-450db1 gene (P450C2D1) associated with genetically deficient metabolism of debrisoquine and other drugs. (PubMed id 2899325)4 Skoda R.C....Meyer U.A. (1988)
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External Searches for CYP2D7P1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing CYP2D7P1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing CYP2D7P1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CYP2D7P1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
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|
About This Section
| Patent Information for CYP2D7P1 gene:
Search GeneIP for patents involving CYP2D7P1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CYP2D7P1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CYP2D7P1 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CYP2D7P1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CYP2D7P1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CYP2D7P1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CYP2D7P1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CYP2D7P1 |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYP2D7P1 |
|  |  |  | | | | Search ThermoFisher Antibodies for CYP2D7P1 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat CYP2D7P1 |
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Last full update: 19 Mar 2013 -
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