Aliases for CYP2D7 Gene
- Cytochrome P450 Family 2 Subfamily D Member 7 (Gene/Pseudogene) 2 3 5
- Cytochrome P450, Subfamily IID (Debrisoquine, Sparteine, Etc., -Metabolizing) Cluster 2 3
- Cytochrome P450, Family 2, Subfamily D, Polypeptide 7 Pseudogene 1 2 3
- Cytochrome P450, Subfamily II (Debrisoquine, Sparteine, Etc., -Metabolising), Polypeptide 7 Pseudogene 1 3
- Cytochrome P450, Family 2, Subfamily D, Polypeptide 7 (Gene/Pseudogene) 2
- Putative Cytochrome P450 2D7 3
- EC 18.104.22.168 4
- CYP2D7AP 3
External Ids for CYP2D7 Gene
Previous HGNC Symbols for CYP2D7 Gene
This gene is a member of the cytochrome P450 gene superfamily. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This gene is a segregating pseudogene, where some individuals may have an allele that encodes a functional enzyme, while other individuals have an allele encoding a protein that is predicted to be non-functional. In this case, the functional allele is thought to be rare. This locus is part of a cluster of cytochrome P450 genes on chromosome 22. [provided by RefSeq, Jan 2017]
GeneCards Summary for CYP2D7 Gene
CYP2D7 (Cytochrome P450 Family 2 Subfamily D Member 7 (Gene/Pseudogene)) is a Protein Coding gene. Among its related pathways are Codeine and Morphine Pathway, Pharmacokinetics. GO annotations related to this gene include iron ion binding and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen. An important paralog of this gene is CYP2D6.
UniProtKB/Swiss-Prot for CYP2D7 Gene
May be responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It may be involved in the metabolism of codeine to morphine (PubMed:15051713). However, another study could not confirm it (PubMed:18838503).