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Aliases for CYP2D7 Gene

Aliases for CYP2D7 Gene

  • Cytochrome P450, Family 2, Subfamily D, Polypeptide 7 (Gene/Pseudogene) 2 3
  • Cytochrome P450, Subfamily IID (Debrisoquine, Sparteine, Etc., -Metabolizing) Cluster 2 3
  • Cytochrome P450, Family 2, Subfamily D, Polypeptide 7 Pseudogene 1 2 3
  • Cytochrome P450, Subfamily II (Debrisoquine, Sparteine, Etc., -Metabolising), Polypeptide 7 Pseudogene 1 3
  • Cytochrome P450, Family 2, Subfamily D, Polypeptide 7, Pseudogene 3
  • EC 1.14.14.1 4
  • CYP2D7AP 3
  • CYP2D7P1 3
  • P450C2D 3
  • P450DB1 3
  • CYP2D7P 3
  • CYP2D@ 3
  • CYP2D 3

External Ids for CYP2D7 Gene

Previous HGNC Symbols for CYP2D7 Gene

  • CYP2D
  • CYP2D@
  • CYP2D7P1
  • CYP2D7P

Summaries for CYP2D7 Gene

Entrez Gene Summary for CYP2D7 Gene

  • This pseudogene is a member of the cytochrome P450 gene superfamily. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. It is possible that, in rare cases, a combination of two SNPs in this gene may result in an open reading frame encoding a functional enzyme which metabolizes codeine to morphine. This locus is part of a cluster of cytochrome P450 genes on chromosome 22q13.1. [provided by RefSeq, Jul 2008]

GeneCards Summary for CYP2D7 Gene

CYP2D7 (Cytochrome P450, Family 2, Subfamily D, Polypeptide 7 (Gene/Pseudogene)) is a Protein Coding gene. Among its related pathways are Codeine and Morphine Pathway, Pharmacokinetics.

UniProtKB/Swiss-Prot for CYP2D7 Gene

  • May be responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It may be involved in the metabolism of codeine to morphine (PubMed:15051713). However, another study could not confirm it (PubMed:18838503).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYP2D7 Gene

Genomics for CYP2D7 Gene

Genomic Location for CYP2D7 Gene

Start:
42,140,203 bp from pter
End:
42,144,577 bp from pter
Size:
4,375 bases
Orientation:
Minus strand

Genomic View for CYP2D7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CYP2D7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYP2D7 Gene

No data available for Regulatory Elements for CYP2D7 Gene

Proteins for CYP2D7 Gene

  • Protein details for CYP2D7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A0A087X1C5-CP2D7_HUMAN
    Recommended name:
    Putative cytochrome P450 2D7
    Protein Accession:
    A0A087X1C5
    Secondary Accessions:
    • Q6XP50

    Protein attributes for CYP2D7 Gene

    Size:
    515 amino acids
    Molecular mass:
    57489 Da
    Cofactor:
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Quaternary structure:
    No Data Available

neXtProt entry for CYP2D7 Gene

Proteomics data for CYP2D7 Gene at MOPED

Post-translational modifications for CYP2D7 Gene

No Post-translational modifications

Other Protein References for CYP2D7 Gene

No data available for DME Specific Peptides for CYP2D7 Gene

Domains for CYP2D7 Gene

Gene Families for CYP2D7 Gene

HGNC:
  • CYP :Cytochrome P450s

Protein Domains for CYP2D7 Gene

Graphical View of Domain Structure for InterPro Entry

A0A087X1C5

UniProtKB/Swiss-Prot:

CP2D7_HUMAN :
  • A0A087X1C5
Family:
  • Belongs to the cytochrome P450 family.
genes like me logo Genes that share domains with CYP2D7: view

No data available for Suggested Antigen Peptide Sequences for CYP2D7 Gene

Function for CYP2D7 Gene

Molecular function for CYP2D7 Gene

UniProtKB/Swiss-Prot CatalyticActivity: RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O.
UniProtKB/Swiss-Prot Function: May be responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It may be involved in the metabolism of codeine to morphine (PubMed:15051713). However, another study could not confirm it (PubMed:18838503).

Enzyme Numbers (IUBMB) for CYP2D7 Gene

Gene Ontology (GO) - Molecular Function for CYP2D7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005506 iron ion binding --
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen --
GO:0020037 heme binding --
genes like me logo Genes that share ontologies with CYP2D7: view

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CYP2D7 Gene

Localization for CYP2D7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYP2D7 Gene

Membrane; Multi-pass membrane protein. Cytoplasm. Mitochondrion.

No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for CYP2D7 Gene

Pathways for CYP2D7 Gene

genes like me logo Genes that share pathways with CYP2D7: view

Pathways by source for CYP2D7 Gene

1 PharmGKB pathway for CYP2D7 Gene

Interacting Proteins for CYP2D7 Gene

Gene Ontology (GO) - Biological Process for CYP2D7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055114 oxidation-reduction process --
genes like me logo Genes that share ontologies with CYP2D7: view

Transcripts for CYP2D7 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CYP2D7

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CYP2D7 Gene

No ASD Table

Relevant External Links for CYP2D7 Gene

GeneLoc Exon Structure for
CYP2D7
ECgene alternative splicing isoforms for
CYP2D7

Expression for CYP2D7 Gene

mRNA expression in normal human tissues for CYP2D7 Gene

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for CYP2D7 Gene

mRNA Expression by UniProt/SwissProt for CYP2D7 Gene

A0A087X1C5-CP2D7_HUMAN
Tissue specificity: Expressed in brain cortex (at protein level).
genes like me logo Genes that share expressions with CYP2D7: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for CYP2D7 Gene

Orthologs for CYP2D7 Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for CYP2D7 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Cyp2d37-ps 36
  • 17 (a)
OneToOne
Species with no ortholog for CYP2D7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CYP2D7 Gene

ENSEMBL:
Gene Tree for CYP2D7 (if available)
TreeFam:
Gene Tree for CYP2D7 (if available)

Paralogs for CYP2D7 Gene

Pseudogenes.org Pseudogenes for CYP2D7 Gene

genes like me logo Genes that share paralogs with CYP2D7: view

No data available for Paralogs for CYP2D7 Gene

Variants for CYP2D7 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for CYP2D7 Gene

A0A087X1C5-CP2D7_HUMAN
A rare double polymorphism may allow the expression of a functional protein (PubMed:15051713). However, following studies could not confirm the combined existence of both polymorphisms and therefore question the existence of that protein (PubMed:16169517, PubMed:17494644).

Sequence variations from dbSNP and Humsavar for CYP2D7 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs762554 -- 42,142,237(-) CGTTG(G/T)AGATT intron-variant
rs769256 -- 42,145,142(-) tctgc(A/G)tgtgt upstream-variant-2KB
rs769260 -- 42,143,719(-) CCCCA(C/G)GATCA intron-variant
rs769261 -- 42,143,622(-) TGGGG(G/T)GATCC intron-variant
rs915947 -- 42,140,943(-) ACAAA(C/T)CAGGA intron-variant

Relevant External Links for CYP2D7 Gene

HapMap Linkage Disequilibrium report
CYP2D7

No data available for Structural Variations from Database of Genomic Variants (DGV) for CYP2D7 Gene

Disorders for CYP2D7 Gene

No disorders were found for CYP2D7 Gene.

No data available for UniProtKB/Swiss-Prot for CYP2D7 Gene

Publications for CYP2D7 Gene

  1. Frequency of the frame-shifting CYP2D7 138delT polymorphism in a large, ethnically diverse sample population. (PMID: 17494644) Bhathena A. … Katz D.A. (Drug Metab. Dispos. 2007) 2 3 4
  2. A frameshift mutation and alternate splicing in human brain generate a functional form of the pseudogene cytochrome P4502D7 that demethylates codeine to morphine. (PMID: 15051713) Pai H.V. … Ravindranath V. (J. Biol. Chem. 2004) 3 4
  3. CYP2D7 splice variants in human liver and brain: does CYP2D7 encode functional protein? (PMID: 16169517) Gaedigk A. … Leeder J.S. (Biochem. Biophys. Res. Commun. 2005) 3 4
  4. Single-nucleotide polymorphisms in NAGNAG acceptors are highly predictive for variations of alternative splicing. (PMID: 16400609) Hiller M. … Platzer M. (Am. J. Hum. Genet. 2006) 3
  5. Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants. (PMID: 15128046) Nelson D.R. … Nebert D.W. (Pharmacogenetics 2004) 3

Products for CYP2D7 Gene

  • QIAGEN qRT-PCR Assays for microRNAs that regulate CYP2D7
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for CYP2D7
    • Block miRNA regulation of CYP2D7 using miScript Target Protectors

    Sources for CYP2D7 Gene

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