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Aliases for CYP2D7 Gene

Aliases for CYP2D7 Gene

  • Cytochrome P450, Family 2, Subfamily D, Polypeptide 7 (Gene/Pseudogene) 2 3
  • Cytochrome P450, Subfamily IID (Debrisoquine, Sparteine, Etc., -Metabolizing) Cluster 2 3
  • Cytochrome P450, Family 2, Subfamily D, Polypeptide 7 Pseudogene 1 2 3
  • Cytochrome P450, Subfamily II (Debrisoquine, Sparteine, Etc., -Metabolising), Polypeptide 7 Pseudogene 1 3
  • Cytochrome P450, Family 2, Subfamily D, Polypeptide 7, Pseudogene 3
  • Putative Cytochrome P450 2D7 3
  • EC 1.14.14.1 4
  • CYP2D7AP 3
  • RNA40057 3
  • CYP2D7P1 3
  • P450C2D 3
  • P450DB1 3
  • CYP2D7P 3
  • CYP2D@ 3
  • CYP2D 3

External Ids for CYP2D7 Gene

Previous HGNC Symbols for CYP2D7 Gene

  • CYP2D
  • CYP2D@
  • CYP2D7P1
  • CYP2D7P

Summaries for CYP2D7 Gene

Entrez Gene Summary for CYP2D7 Gene

  • This pseudogene is a member of the cytochrome P450 gene superfamily. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. It is possible that, in rare cases, a combination of two SNPs in this gene may result in an open reading frame encoding a functional enzyme which metabolizes codeine to morphine. This locus is part of a cluster of cytochrome P450 genes on chromosome 22q13.1. [provided by RefSeq, Jul 2008]

GeneCards Summary for CYP2D7 Gene

CYP2D7 (Cytochrome P450, Family 2, Subfamily D, Polypeptide 7 (Gene/Pseudogene)) is a Protein Coding gene. Diseases associated with CYP2D7 include debrisoquine sensitivity. Among its related pathways are Codeine and Morphine Pathway, Pharmacokinetics. GO annotations related to this gene include iron ion binding and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen.

UniProtKB/Swiss-Prot for CYP2D7 Gene

  • May be responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It may be involved in the metabolism of codeine to morphine (PubMed:15051713). However, another study could not confirm it (PubMed:18838503).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYP2D7 Gene

Genomics for CYP2D7 Gene

Genomic Location for CYP2D7 Gene

Chromosome:
22
Start:
42,140,203 bp from pter
End:
42,144,577 bp from pter
Size:
4,375 bases
Orientation:
Minus strand

Genomic View for CYP2D7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CYP2D7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYP2D7 Gene

No data available for Regulatory Elements for CYP2D7 Gene

Proteins for CYP2D7 Gene

  • Protein details for CYP2D7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A0A087X1C5-CP2D7_HUMAN
    Recommended name:
    Putative cytochrome P450 2D7
    Protein Accession:
    A0A087X1C5
    Secondary Accessions:
    • Q6XP50

    Protein attributes for CYP2D7 Gene

    Size:
    515 amino acids
    Molecular mass:
    57489 Da
    Cofactor:
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Quaternary structure:
    No Data Available

neXtProt entry for CYP2D7 Gene

Proteomics data for CYP2D7 Gene at MOPED

Post-translational modifications for CYP2D7 Gene

Other Protein References for CYP2D7 Gene

No data available for DME Specific Peptides for CYP2D7 Gene

Domains & Families for CYP2D7 Gene

Gene Families for CYP2D7 Gene

Protein Domains for CYP2D7 Gene

Suggested Antigen Peptide Sequences for CYP2D7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A0A087X1C5

UniProtKB/Swiss-Prot:

CP2D7_HUMAN :
  • Belongs to the cytochrome P450 family.
Family:
  • Belongs to the cytochrome P450 family.
genes like me logo Genes that share domains with CYP2D7: view

Function for CYP2D7 Gene

Molecular function for CYP2D7 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O.
UniProtKB/Swiss-Prot Function:
May be responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It may be involved in the metabolism of codeine to morphine (PubMed:15051713). However, another study could not confirm it (PubMed:18838503).

Enzyme Numbers (IUBMB) for CYP2D7 Gene

Gene Ontology (GO) - Molecular Function for CYP2D7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004497 monooxygenase activity --
GO:0005506 iron ion binding IEA --
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen --
GO:0020037 heme binding IEA --
GO:0070330 NOT aromatase activity IDA 18838503
genes like me logo Genes that share ontologies with CYP2D7: view

Phenotypes for CYP2D7 Gene

GenomeRNAi human phenotypes for CYP2D7:
genes like me logo Genes that share phenotypes with CYP2D7: view

No data available for Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CYP2D7 Gene

Localization for CYP2D7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYP2D7 Gene

Membrane; Multi-pass membrane protein. Cytoplasm. Mitochondrion.

Gene Ontology (GO) - Cellular Components for CYP2D7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 15051713
GO:0005739 mitochondrion IDA 18838503
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CYP2D7: view

No data available for Subcellular locations from COMPARTMENTS for CYP2D7 Gene

Pathways & Interactions for CYP2D7 Gene

genes like me logo Genes that share pathways with CYP2D7: view

Pathways by source for CYP2D7 Gene

1 PharmGKB pathway for CYP2D7 Gene

Interacting Proteins for CYP2D7 Gene

Gene Ontology (GO) - Biological Process for CYP2D7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006805 NOT xenobiotic metabolic process IDA 18838503
GO:0042738 NOT exogenous drug catabolic process IDA 18838503
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with CYP2D7: view

No data available for SIGNOR curated interactions for CYP2D7 Gene

Drugs & Compounds for CYP2D7 Gene

No Compound Related Data Available

Transcripts for CYP2D7 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for CYP2D7 Gene

No ASD Table

Relevant External Links for CYP2D7 Gene

GeneLoc Exon Structure for
CYP2D7
ECgene alternative splicing isoforms for
CYP2D7

Expression for CYP2D7 Gene

mRNA expression in normal human tissues for CYP2D7 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CYP2D7 Gene



mRNA Expression by UniProt/SwissProt for CYP2D7 Gene

A0A087X1C5-CP2D7_HUMAN
Tissue specificity: Expressed in brain cortex (at protein level).
genes like me logo Genes that share expression patterns with CYP2D7: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Protein tissue co-expression partners for CYP2D7 Gene

Orthologs for CYP2D7 Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for CYP2D7 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Cyp2d37-ps 36
  • 17 (a)
OneToOne
Species with no ortholog for CYP2D7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CYP2D7 Gene

ENSEMBL:
Gene Tree for CYP2D7 (if available)
TreeFam:
Gene Tree for CYP2D7 (if available)

Paralogs for CYP2D7 Gene

Pseudogenes.org Pseudogenes for CYP2D7 Gene

genes like me logo Genes that share paralogs with CYP2D7: view

No data available for Paralogs for CYP2D7 Gene

Variants for CYP2D7 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for CYP2D7 Gene

A0A087X1C5-CP2D7_HUMAN
A rare double polymorphism may allow the expression of a functional protein (PubMed:15051713). However, following studies could not confirm the combined existence of both polymorphisms and therefore question the existence of that protein (PubMed:16169517, PubMed:17494644).

Sequence variations from dbSNP and Humsavar for CYP2D7 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs769260 -- 42,143,719(-) CCCCA(C/G)GATCA intron-variant
rs769261 -- 42,143,622(-) TGGGG(G/T)GATCC intron-variant
rs2854740 -- 42,142,896(-) ACGTG(C/T)CCGTC intron-variant
rs3020737 -- 42,140,963(-) GCCCC(A/C)GTCTA intron-variant
rs3021085 -- 42,140,371(-) TTCTC(C/G)GTGGC nc-transcript-variant

Relevant External Links for CYP2D7 Gene

HapMap Linkage Disequilibrium report
CYP2D7

No data available for Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for CYP2D7 Gene

Disorders for CYP2D7 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CYP2D7 Gene - From: OMIM

Disorder Aliases PubMed IDs
debrisoquine sensitivity
  • codeine sensitivity
- elite association

Relevant External Links for CYP2D7

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CYP2D7
genes like me logo Genes that share disorders with CYP2D7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CYP2D7 Gene

Publications for CYP2D7 Gene

  1. Frequency of the frame-shifting CYP2D7 138delT polymorphism in a large, ethnically diverse sample population. (PMID: 17494644) Bhathena A. … Katz D.A. (Drug Metab. Dispos. 2007) 2 67
  2. Alternative splicing of CYP2D mRNA in human breast tissue. (PMID: 9210651) Huang Z. … Kaminsky L.S. (Arch. Biochem. Biophys. 1997) 23 67
  3. Molecular genetics of cytochrome P450 IID. Anomalies of drug metabolism. (PMID: 8535928) Jacqz-Aigrain E. … Krishnamoorthy R. (Clin Rev Allergy Immunol 1995) 23 67
  4. Regulation of cytochrome P450 IID by acute phase mediators in C3H/HeJ mice. (PMID: 1370887) Trautwein C. … Manns M. (Biochem. Biophys. Res. Commun. 1992) 23 67
  5. Coding-noncoding gene expression in intrahepatic cholangiocarcinoma. (PMID: 26297049) Wang J. … Zheng S. (Transl Res 2015) 67

Products for CYP2D7 Gene

Sources for CYP2D7 Gene

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