Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CYP2C9 Gene

protein-coding   GIFtS: 69
GCID: GC10P096688

Cytochrome P450, Family 2, Subfamily C, Polypeptide 9

(Previous names: cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase),...)
(Previous symbol: CYP2C10)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Cytochrome P450, Family 2, Subfamily C, Polypeptide 91 2     Xenobiotic Monooxygenase2
CYP2C101 2 3     (R)-Limonene 6-Monooxygenase3
Cytochrome P-450MP2 3     (S)-Limonene 6-Monooxygenase3
Cytochrome P450 PB-12 3     (S)-Limonene 7-Monooxygenase3
CYPIIC92 3     EC 1.14.13.-3
Cytochrome P450, Subfamily IIC (Mephenytoin 4-Hydroxylase), Polypeptide 91     EC 1.14.13.483
CPC92     EC 1.14.13.493
CYP2C2     EC 1.14.13.803
P450IIC92     Cytochrome P450 MP-43
Cytochrome P-450 S-Mephenytoin 4-Hydroxylase2     Cytochrome P450 MP-83
Cytochrome P450 2C92     S-Mephenytoin 4-Hydroxylase3
Flavoprotein-Linked Monooxygenase2     EC 1.14.14.18
Microsomal Monooxygenase2     

External Ids:    HGNC: 26231   Entrez Gene: 15592   Ensembl: ENSG000001381097   OMIM: 6011305   UniProtKB: P117123   

Export aliases for CYP2C9 gene to outside databases

Previous GC identifers: GC10P095591 GC10P095932 GC10P096829 GC10P096363 GC10P090325


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CYP2C9 Gene:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are
monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids
and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by rifampin.
The enzyme is known to metabolize many xenobiotics, including phenytoin, tolbutamide, ibuprofen and S-warfarin.
Studies identifying individuals who are poor metabolizers of phenytoin and tolbutamide suggest that this gene is
polymorphic. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. (provided by
RefSeq, Jul 2008)

GeneCards Summary for CYP2C9 Gene: 
CYP2C9 (cytochrome P450, family 2, subfamily C, polypeptide 9) is a protein-coding gene. Diseases associated with CYP2C9 include warfarin sensitivity, and warfarin resistance, and among its related super-pathways are Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) and Tamoxifen Pathway, Pharmacokinetics. GO annotations related to this gene include electron carrier activity and heme binding. An important paralog of this gene is CYP2W1.

UniProtKB/Swiss-Prot: CP2C9_HUMAN, P11712
Function: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is
involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated
compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics
variability of the metabolism of drugs such as S-warfarin, diclofenac, phenytoin, tolbutamide and losartan

Gene Wiki entry for CYP2C9 Gene

PharmGKB "VIP" summary for CYP2C9


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NT_030059.13  NC_018921.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CYP2C9 gene promoter:
         COUP-TF1   COUP   HNF-4alpha2   GATA-1   HNF-4alpha1   PPAR-gamma1   COUP-TF   HOXA5   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CYP2C9 promoter sequence
   Search SABiosciences Chromatin IP Primers for CYP2C9

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CYP2C9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q24   Ensembl cytogenetic band:  10q23.33   HGNC cytogenetic band: 10q24.1

CYP2C9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CYP2C9 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P096688:  view genomic region     (about GC identifiers)

Start:
96,698,415 bp from pter      End:
96,749,148 bp from pter
Size:
50,734 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CP2C9_HUMAN, P11712 (See protein sequence)
Recommended Name: Cytochrome P450 2C9  
Size: 490 amino acids; 55628 Da
Cofactor: Heme group
Subcellular location: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral
membrane protein
3 PDB 3D structures from and Proteopedia for CYP2C9:
1OG2 (3D)        1OG5 (3D)        1R9O (3D)    
Secondary accessions: P11713 Q16756 Q16872 Q5VX92

Explore the universe of human proteins at neXtProt for CYP2C9: NX_P11712

Explore proteomics data for CYP2C9 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P11712

  • 4/26 DME Specific Peptides for CYP2C9 (P11712) (see all 26)
     GKLPPGP  PGPTPLP  PFSAGKR  LTSVLHD 

    CYP2C9 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CYP2C9 Protein Expression
    REFSEQ proteins: NP_000762.2  
    ENSEMBL proteins: 
     ENSP00000260682  
    Reactome Protein details: P11712
    Human Recombinant Protein Products for CYP2C9: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for CYP2C9
    OriGene Protein Over-expression Lysate for CYP2C9
    OriGene MassSpec for CYP2C9 
    OriGene Custom Protein Services for CYP2C9
    GenScript Custom Purified and Recombinant Proteins Services for CYP2C9
    Novus Biologicals CYP2C9 Protein
    Novus Biologicals CYP2C9 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CYP2C9 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum NAS--
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0043231intracellular membrane-bounded organelle TAS2827463

    CYP2C9 for ontologies           About GeneDecksing



    CYP2C9 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of CYP2C9
    Browse R&D Systems for Antibodies
    OriGene Antibodies for CYP2C9
    OriGene Custom Antibody Services for CYP2C9
    GenScript Custom Superior Antibodies Services for CYP2C9
    Novus Biologicals CYP2C9 Antibodies
    Abcam antibodies for CYP2C9
    Cloud-Clone Corp. Antibodies for CYP2C9 
    ThermoFisher Antibodies for CYP2C9
    LSBio Antibodies in human, mouse, rat for CYP2C9 

    Assay Products for CYP2C9: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CYP2C9
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CYP2C9
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CYP2C9 
    Cloud-Clone Corp. CLIAs for CYP2C9


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CYP: Cytochrome P450s

    IUPHAR Guide to PHARMACOLOGY protein family classification: CYP2C9 
    CYP2 family

    3 InterPro protein domains:
     IPR001128 Cyt_P450
     IPR017972 Cyt_P450_CS
     IPR002401 Cyt_P450_E_grp-I

    Graphical View of Domain Structure for InterPro Entry P11712

    ProtoNet protein and cluster: P11712

    2 Blocks protein domains:
    IPB002401 E-class P450 group I signature
    IPB008068 CYP2B P450 family signature


    UniProtKB/Swiss-Prot: CP2C9_HUMAN, P11712
    Similarity: Belongs to the cytochrome P450 family


    CYP2C9 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CP2C9_HUMAN, P11712
    Function: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is
    involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated
    compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics
    variability of the metabolism of drugs such as S-warfarin, diclofenac, phenytoin, tolbutamide and losartan
    Catalytic activity: (+)-(R)-limonene + NADPH + O(2) = (+)-trans-carveol + NADP(+) + H(2)O
    Catalytic activity: (-)-(S)-limonene + NADPH + O(2) = (-)-trans-carveol + NADP(+) + H(2)O
    Catalytic activity: (-)-(S)-limonene + NADPH + O(2) = (-)-perillyl alcohol + NADP(+) + H(2)O
    Induction: By rifampicin

         Genatlas biochemistry entry for CYP2C9:
    cytochrome P450,subfamily IIC (mephenytoin 4-hydroxylase),polypeptide 9

         Enzyme Numbers (IUBMB): EC 1.14.13.801 EC 1.14.14.12 EC 1.14.13.491 EC 1.14.13.-1 EC 1.14.13.481

         Gene Ontology (GO): 5/12 molecular function terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004497monooxygenase activity NAS2827463
    GO:0005506iron ion binding IEA--
    GO:0008144drug binding IDA19448135
    GO:0008395steroid hydroxylase activity IMP18356043
    GO:0009055electron carrier activity IEA--
         
    CYP2C9 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CYP2C9 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CYP2C9

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CYP2C9 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CYP2C9 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CYP2C9
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate CYP2C9
    SwitchGear 3'UTR luciferase reporter plasmidCYP2C9 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CYP2C9
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CYP2C9

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CYP2C9
    Sirion Biotech Customized adenovirus for overexpression of CYP2C9

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for CYP2C9 (see all 8)
    OriGene ORF clones in mouse, rat for CYP2C9
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CYP2C9 (NM_000771)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CYP2C9
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CYP2C9
    Sirion Biotech Customized lentivirus for stable overexpression of CYP2C9 
                         Customized lentivirus expression plasmids for stable overexpression of CYP2C9 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CYP2C9
    Search LifeMap BioReagents cell lines for CYP2C9
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYP2C9


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CYP2C9 About   (see all 26)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)
    Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)0.55
    Benzo[a]pyrene metabolism0.43
    Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)0.55
    Arachidonate Epoxygenase / Epoxide Hydrolase0.36
    Warfarin Pathway, Pharmacokinetics0.45
    2Tamoxifen metabolism
    Tamoxifen metabolism0.68
    Estradiol metabolism0.52
    Tamoxifen Pathway, Pharmacokinetics0.68
    3Arachidonic acid metabolism
    Arachidonic acid metabolism0.44
    HETE and HPETE biosynthesis and metabolism0.35
    Arachidonic acid metabolism0.44
    4Cytochrome P450 - arranged by substrate type
    Cytochrome P450 - arranged by substrate type0.75
    Phase 1 - Functionalization of compounds0.74
    cytochrome P4500.75
    5Metabolism
    Metabolism0.40
    Metabolism of lipids and lipoproteins0.34
    Metabolic pathways0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/10 EMD Millipore Pathways for CYP2C9 (see all 10)
        Androstenedione and testosterone biosynthesis and metabolism p.1
    Estradiol metabolism
    Retinol metabolism
    Naphthalene metabolism
    Selected targets of GCR-alpha


    5/9 GeneGo (Thomson Reuters) Pathways for CYP2C9 (see all 9)
        Estrogen biosynthesis
    HETE and HPETE biosynthesis and metabolism
    Naphthalene metabolism
    Estradiol metabolism
    Retinol metabolism

    5 BioSystems Pathways for CYP2C9
        cytochrome P450
    Arachidonate Epoxygenase / Epoxide Hydrolase
    Tamoxifen metabolism
    Nuclear receptors in lipid metabolism and toxicity
    metapathway biotransformation

    5/10        Reactome Pathways for CYP2C9 (see all 10)
        Cytochrome P450 - arranged by substrate type
    Xenobiotics
    Metabolism
    Arachidonic acid metabolism
    CYP2E1 reactions

    5/23 PharmGKB Pathways for CYP2C9 (see all 23)
        Anti-diabetic Drug Nateglinide Pathway, Pharmacokinetics
    Atorvastatin/Lovastatin/Simvastatin Pathway, Pharmacokinetics
    Caffeine Pathway, Pharmacokinetics
    Celecoxib Pathway, Pharmacokinetics
    Clopidogrel Pathway, Pharmacokinetics

    5/8         Kegg Pathways  (Kegg details for CYP2C9) (see all 8):
        Arachidonic acid metabolism
    Linoleic acid metabolism
    Retinol metabolism
    Metabolism of xenobiotics by cytochrome P450
    Drug metabolism - cytochrome P450


    CYP2C9 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CYP2C9

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/103 Interacting proteins for CYP2C9 (P117123 ENSP000002606824) via UniProtKB, MINT, STRING, and/or I2D (see all 103)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RAB3DO957163, ENSP000002221204I2D: score=1 STRING: ENSP00000222120
    PORP164353I2D: score=2 
    CDC37Q165433I2D: score=1 
    MAST1Q9Y2H93I2D: score=1 
    RNF32Q9H0A63I2D: score=1 
    About this table

    Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006805xenobiotic metabolic process TAS--
    GO:0008202steroid metabolic process IMP18356043
    GO:0016098monoterpenoid metabolic process IDA16401082
    GO:0017144drug metabolic process IMP--
    GO:0019369arachidonic acid metabolic process TAS--

    CYP2C9 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CYP2C9 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Enzo Life Sciences drugs & compounds for CYP2C9

    Browse Tocris compounds for CYP2C9 (CP2C9)

    10/60 HMDB Compounds for CYP2C9 (see all 60)    About this table
    CompoundSynonyms CAS #PubMed Ids
    Melatonin5-Methoxy-N-acetyltryptamine (see all 23)73-31-420167001
    (+)-Limonene(+)-(4R)-Limonene (see all 2)5989-27-5--
    (-)-trans-CarveolCarveol 1197-07-5--
    11,12,15-THETA11,12,15-Trihydroxyicosatrienoic acid (see all 5)----
    11,12-Epoxyeicosatrienoic acid10-(3-(2-octenyl)oxiranyl)-5,8-Decadienoic acid (see all 15)81276-02-0--
    11,14,15-THETA(5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoic acid (see all 8)----
    11H-14,15-EETA14,15-Ep-11-HETrE (see all 11)219535-29-2--
    12,13-EpOMEVernolic acid (see all 12)----
    13-HETE13-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoate (see all 2)151910-72-4--
    14,15-Epoxy-5,8,11-eicosatrienoic acid(5Z,8Z,11Z)-14,15-Epoxyicosa-5.8.11-trienoic acid (see all 11)81276-03-1--

    10/275 DrugBank Compounds for CYP2C9 (see all 275)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    AcenocoumarolAcenocoumarin (see all 7)152-72-7enzymesubstrate inhibitor15790782 18698879 16815313 16869821 16611310 17596133 19934256 19515014
    LornoxicamAcabel (see all 12)70374-39-9enzymesubstrate inhibitor16118328 15606435 10640513 17022718 19934256 19515014 8857077
    Celecoxib-- 169590-42-5enzymesubstrate11259318 10749518 19934256 20167001 19515014
    DiclofenacDiclofenac Acid (see all 4)15307-86-5enzymesubstrate inhibitor8417277 12065442 19934256 20167001 19515014
    Fluvastatin-- 93957-54-1enzymesubstrate inhibitor inducer11368292 19663817 19934256 10064574 19515014
    LosartanDuP 89 (see all 2)114798-26-4enzymesubstrate inhibitor11823761 16029066 10678291 19934256 19515014
    Phenytoin5,5-diphenylhydantoin (see all 13)57-41-0enzymesubstrate inhibitor inducer15805193 8806399 19934256 11038165 19515014
    AmitriptylineAmitriprolidine (see all 5)50-48-6enzymesubstrate11259560 9131945 19934256 19515014
    FlurbiprofenFLP (see all 5)5104-49-4enzymesubstrate11259318 19934256 20167001 19515014
    Fosphenytoin(3-Phosphoryloxymethyl)phenytoin (see all 5)93390-81-9enzymesubstrate inducer19202563 17375979 19515014 11678778

    10/151 Novoseek inferred chemical compound relationships for CYP2C9 gene (see all 151)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    vitamin k epoxide 94.4 65 19181737 (2), 17049586 (2), 15790782 (2), 18240910 (1) (see all 43)
    s-warfarin 92.6 61 20429590 (6), 16758259 (4), 19679631 (4), 9526963 (3) (see all 28)
    sulfaphenazole 92.2 26 10079071 (2), 8857077 (2), 10548450 (1), 15304426 (1) (see all 19)
    tolbutamide 89 85 9578596 (6), 8518837 (3), 15325841 (3), 11875364 (3) (see all 49)
    warfarin 88.4 351 19077919 (6), 18542936 (5), 17049586 (5), 16413010 (5) (see all 99)
    tienilic acid 85 14 7654690 (3), 8905121 (1), 8902272 (1), 9112234 (1) (see all 9)
    acenocoumarol 84.7 40 19225451 (4), 16869821 (3), 20020283 (3), 19578179 (2) (see all 23)
    furafylline 83.4 2 9431831 (1), 11317475 (1)
    androstane 82.2 20 16188404 (2), 12181452 (2), 20167002 (1), 12815172 (1) (see all 11)
    diclofenac 80.2 67 11829203 (6), 12534640 (5), 15135088 (2), 15486075 (2) (see all 41)

    10/17 PharmGKB related drug/compound annotations for CYP2C9 gene (see all 17)    About this table
    Drug/compound PharmGKB Annotation
    Antiinflammatory agents, non-steroidsCA  
    sulfonamides, urea derivativesCA  
    acenocoumarol  CA  
    celecoxib  CA  
    clopidogrelCA  
    diclofenacCA  
    flurbiprofen
    fluvoxamine
    glibenclamide
    gliclazide

    Search CenterWatch for drugs/clinical trials and news about CYP2C9 / CP2C9

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CYP2C9 gene: 
    NM_000771.3  

    Unigene Cluster for CYP2C9:

    Cytochrome P450, family 2, subfamily C, polypeptide 9
    Hs.282624  [show with all ESTs]
    Unigene Representative Sequence: NM_000771
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000461906(uc001kjz.3) ENST00000260682(uc001kka.4 uc009xut.3)
    ENST00000473496

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CYP2C9
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate CYP2C9
    SwitchGear 3'UTR luciferase reporter plasmidCYP2C9 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CYP2C9
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CYP2C9
    Clone
    Products:
         
    OriGene clones in human, mouse for CYP2C9 (see all 8)
    OriGene ORF clones in mouse, rat for CYP2C9
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CYP2C9 (NM_000771)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CYP2C9
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CYP2C9
    Sirion Biotech Customized lentivirus for stable overexpression of CYP2C9 
                         Customized lentivirus expression plasmids for stable overexpression of CYP2C9 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CYP2C9
    OriGene qSTAR qPCR primer pairs in human, mouse for CYP2C9
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat CYP2C9
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CYP2C9
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CYP2C9

    Additional mRNA sequence: 

    AK289420.1 AK298458.1 BC020754.1 BC070317.1 BC125054.1 D00173.1 M15331.1 M21939.1 
    M21940.1 M61855.1 M61857.1 S46963.1 

    12 DOTS entries:

    DT.442309  DT.92457811  DT.92457774  DT.121303397  DT.92034871  DT.92457778  DT.95168915  DT.92457798 
    DT.121303420  DT.92457789  DT.91802519  DT.92457782 

    24/175 AceView cDNA sequences (see all 175):

    AV659393 CB163507 BG198890 S46963 T54023 CB163188 AV649420 AV651922 
    AV651614 AV649415 BC020754 AV659109 CB161481 BG569544 CB162071 CB163889 
    AV656568 AV652439 CB162668 AV651935 AV649200 AV648351 CB154328 AV648214 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for CYP2C9    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9
    SP1:                                      -                 -                           
    SP2:                                      -                 -     -                     
    SP3:                                      -                                             
    SP4:                                                                                    


    ECgene alternative splicing isoforms for CYP2C9

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CYP2C9 expression in normal human tissues (normalized intensities)      CYP2C9 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CYP2C9 Expression
    About this image


    CYP2C9 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/11 selected tissues (see all 11) fully expand
     
     Intestine (Gastrointestinal Tract)    fully expand to see all 3 entries
             small intestine ; glandular cells   
             small intestine   
     
     Liver (Hepatobiliary System)    fully expand to see all 3 entries
             Mature Hepatocytes Liver Lobule
     
     Colon (Gastrointestinal Tract)    fully expand to see all 2 entries
             colon ; glandular cells   
             Appendix   
     
     Heart (Cardiovascular System)
             Atrioventricular Node
     
     Endothelium (Cardiovascular System)
             blood vessel   

    See CYP2C9 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CYP2C9

    SOURCE GeneReport for Unigene cluster: Hs.282624
        SABiosciences Expression via Pathway-Focused PCR Arrays including CYP2C9 (see all 6): 
              Nephrotoxicity in human mouse rat
              Cancer Drug Resistance in human mouse rat
              Drug Metabolism: Phase I Enzymes in human mouse rat
              Cellular Stress Responses in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CYP2C9
    OriGene qSTAR qPCR primer pairs in human, mouse for CYP2C9
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat CYP2C9
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CYP2C9
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CYP2C9
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYP2C9

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CYP2C9 gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cyp2c551 , 5 cytochrome P450, family 2, subfamily c, polypeptide more1, 5 79.55(n)1
    74.44(a)1
      19 (33.64 cM)5
    720821  NM_028089.31  NP_082365.11 
     390070195 
    chicken
    (Gallus gallus)
    Aves CYP2C451 cytochrome P-450 2C45 63.57(n)
    58.14(a)
      414833  NM_001001752.1  NP_001001752.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 8)
    --
    57(a)
    57(a)
    (see all 8)
    many ↔ many
    many ↔ many
    (see all 8)
    GL343274.1(1228542-1242539)
    GL343274.1(1268879-1309429)


    ENSEMBL Gene Tree for CYP2C9 (if available)
    TreeFam Gene Tree for CYP2C9 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CYP2C9 gene
    CYP2W12  CYP2C82  CYP2A62  CYP2F12  CYP2A72  CYP2B62  CYP2C192  CYP2R12  
    CYP2J22  CYP2U12  CYP2S12  CYP2E12  CYP2D62  CYP2C182  CYP2A132  
    18/38 SIMAP similar genes for CYP2C9 using alignment to 6 protein entries:     CP2C9_HUMAN (see all proteins) (see all similar genes):
    CYP2C19    CYP 2C    CYP2C18    CYP2C    DKFZp686I24235    CYP2C8
    CYP2E1    CYP2G1P    CYP2A13    CYP2A6    CYP2B    CYP2B7
    CYP2A7    CYP2A6V2    CYP2B6    CYP2F1    CYP2S1    CYP2W1

    CYP2C9 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CYP2C9
    PGOHUM00000238611


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1422 SNPs in CYP2C9 are shown (see all 1422)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs725581911,2
    Cpathogenic197070876(+) AGATTG/TTGAGC 2 V L mis10--------
    rs10579101,2,4
    C,F,Hpathogenic197104254(+) GATACA/CTTGAC 2 I L mis141Minor allele frequency- C:0.04MN NS EA NA EU 11706
    rs725581871,2
    Cuntested197064915(+) TGATCC/TTGGAG 2 P L mis10--------
    rs725581891,2
    Cuntested197065191(+) CCGGCA/GTTTCT 2 H R mis10--------
    rs17998531,2,4
    C,F,Hother197065247(+) AGGACC/TGTGTT 2 R C mis1 ese324Minor allele frequency- T:0.10MN NS NA EA EU 9812
    VAR_0083464
    ----see VAR_0083462 G D mis40--------
    VAR_0188624
    ----see VAR_0188622 L I mis40--------
    rs2010228581,2
    --90360703(+) TTGTT-/TTGTTTTT 1 -- cds10--------
    rs114565101,2
    C--90360704(+) TGTTT-/T/TG  
            
    TTTTT
    1 -- int1 trp30--------
    rs1441016081,2
    C--90362518(+) TTTAA-/TTTTTT 1 -- int10--------

    HapMap Linkage Disequilibrium report for CYP2C9 (96698415 - 96749148 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for CYP2C9:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2739707CNV Deletion23290073
    esv2674280CNV Deletion23128226
    esv2741937CNV Deletion23290073
    nsv7497CNV Insertion18451855


    Human Gene Mutation Database (HGMD): CYP2C9

    Locus Specific Mutation Databases (LSDB): CYP2C9
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CYP2C9
    DNA2.0 Custom Variant and Variant Library Synthesis for CYP2C9

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601130   
    OMIM disorders: 122700  
    20/68 diseases for CYP2C9 (see all 68):    About MalaCards
    warfarin sensitivity    warfarin resistance    cytochrome p450    drug-induced hepatitis
    portal vein thrombosis    back pain    thromboembolism    gastroduodenitis
    essential tremor    deep vein thrombosis    gingival overgrowth    tremor
    gastric ulcer    obesity, association with    antiphospholipid syndrome    gingivitis
    oral lichen planus    sudden infant death syndrome    venous thromboembolism    thrombosis


    CYP2C9 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/23 Novoseek inferred disease relationships for CYP2C9 gene (see all 23)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    bleeding 42.8 51 14707031 (3), 18756910 (3), 17681167 (3), 20362363 (3) (see all 27)
    thromboembolism 26.1 1 18542936 (1)
    genetic susceptibility 25 1 17681167 (1)
    hepatitis autoimmune 16.8 1 8700140 (1)
    renal failure chronic 5.62 1 12732848 (1)
    schizophrenia 3.17 1 10813809 (1)
    necrosis 2.29 3 8232220 (1), 17576808 (1), 19448967 (1)
    tumors 0.11 11 14759713 (3), 8232220 (1), 10991840 (1), 19448967 (1) (see all 6)
    astrocytoma 0 1 16188404 (1)
    stroke 0 4 17049586 (1), 20073138 (1), 18788834 (1)

    Genetic Association Database (GAD): CYP2C9
    Human Genome Epidemiology (HuGE) Navigator: CYP2C9 (553 documents)

    Export disorders for CYP2C9 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CYP2C9 gene, integrated from 9 sources (see all 1216):
    (articles sorted by number of sources associating them with CYP2C9)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Lornoxicam pharmacokinetics in relation to cytochrome P450 2C9 genotype. (PubMed id 15606435)1, 4, 7, 9 Zhang Y....Zhou H. (2005)
    2. Pharmacogenetics of oral anticoagulants: a basis for dose individualization. (PubMed id 18698879)1, 4, 7, 9 Stehle S....Fuhr U. (2008)
    3. The risk of myocardial infarction in patients with reduced activity of cytochrome P450 2C9. (PubMed id 17558303)1, 4, 7, 9 Visser L.E....Stricker B.H. (2007)
    4. The genetic interaction between VKORC1 c1173t and calumenin a29809g modulates the anticoagulant response of acenocoumarol. (PubMed id 17596133)1, 4, 7 Gonzalez-Conejero R....Vicente V. (2007)
    5. VKORC1 and CYP2C9 genotypes and phenprocoumon anticoagulation status: interaction between both genotypes affects dose requirement. (PubMed id 17192772)1, 4, 7 Schalekamp T....de Boer A. (2007)
    6. VKORC1 and CYP2C9 genotypes and acenocoumarol anticoagulation status: interaction between both genotypes affects overanticoagulation. (PubMed id 16815313)1, 4, 7 Schalekamp T....de Boer A. (2006)
    7. Contributions of CYP2D6, CYP2C9 and CYP2C19 to the biotransformation of E- and Z-doxepin in healthy volunteers. (PubMed id 12360109)1, 4, 7 Kirchheiner J....Brockmoller J. (2002)
    8. Association between CYP2C9 genetic variants and anticoagulation- related outcomes during warfarin therapy. (PubMed id 11926893)1, 2, 4 Higashi M.K.... Rettie A.E. (2002)
    9. Genetic susceptibility to nonsteroidal anti-inflammatory drug-related gastroduodenal bleeding: role of cytochrome P450 2C9 polymorphisms. (PubMed id 17681167)1, 4, 9 Pilotto A....Dallapiccola B. (2007)
    10. CYP2C9, CYP2C19, ABCB1 (MDR1) genetic polymorphisms and phenytoin metabolism in a Black Beninese population. (PubMed id 16220110)1, 4, 9 Allabi A.C....Horsmans Y. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1559 HGNC: 2623 AceView: CYP2C9 Ensembl:ENSG00000138109 euGenes: HUgn1559
    ECgene: CYP2C9 Kegg: 1559 H-InvDB: CYP2C9

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CYP2C9 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CYP2C9 Genetics and Cytogenetics in Oncology and Haematology
    Cytochrome P450 Allele Nomenclature Committeehttp://www.cypalleles.ki.se/cyp2c9.htm
    NIEHS-SNPshttp://egp.gs.washington.edu/data/cyp2c9/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CYP2C9 gene:
    Search GeneIP for patents involving CYP2C9

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     EMD Millipore Mono- and Polyclonal Antibodies for the study of CYP2C9
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Small Molecules at EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for CYP2C9   OriGene RNAi products in human, mouse, rat for CYP2C9  
     OriGene qPCR primer pairs and template standards for CYP2C9   OriGene Protein Over-expression Lysate for CYP2C9  
     OriGene MassSpec something-or-other for CYP2C9   OriGene clones in human, mouse for CYP2C9  
     OriGene qSTAR qPCR primer pairs in human, mouse for CYP2C9   OriGene Purified Protein for CYP2C9  
     OriGene ORF clones in mouse, rat for CYP2C9   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CYP2C9   OriGene Custom Protein Services for CYP2C9  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CYP2C9
     QIAGEN SeqTarget long-range PCR primers for resequencing CYP2C9
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CYP2C9
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CYP2C9
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CYP2C9
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CYP2C9
     GenScript Custom Purified and Recombinant Proteins Services for CYP2C9 GenScript cDNA clones with any tag delivered in your preferred vector for CYP2C9
     GenScript Custom Assay Services for CYP2C9 GenScript Custom Superior Antibodies Services for CYP2C9
     GenScript Custom overexpressing Cell Line Services for CYP2C9 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in CYP2C9 promoter
     Search Chromatin IP Primers for CYP2C9
     RT2 qPCR Primer Assay in human, mouse / rat CYP2C9
     GNC Network for CYP2C9
     SABiosciences PCR Arrays including human, mouse / rat CYP2C9
     Search Tocris compounds for CYP2C9 (CP2C9)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Drugs for CYP2C9
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     CYP2C9 antibodies
     CYP2C9 proteins
     CYP2C9 lysates
     Antibodies for CYP2C9
     See all of Abcam's Antibodies, Kits and Proteins for CYP2C9
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for CYP2C9
     Antibodies for CYP2C9
     ELISAs for CYP2C9
     CLIAs for CYP2C9
     Search LifeMap BioReagents cell lines for CYP2C9
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYP2C9
     SwitchGear 3'UTR luciferase reporter plasmids for CYP2C9
     SwitchGear Promoter luciferase reporter plasmids for CYP2C9
     ThermoFisher Antibodies for CYP2C9
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CYP2C9
     inGenious Targeting Laboratory - Custom generated mouse model solutions for CYP2C9
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CYP2C9
    Customized:
     lentivirus for stable overexpression of CYP2C9
     lentivirus expression plasmids for stable overexpression of CYP2C9
     adenovirus for overexpression of CYP2C9
     LSBio Antibodies in human, mouse, rat for CYP2C9
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CYP2C9 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4