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GIFtS
-

CYP2C9 Gene

protein-coding GIFtS: 67
GCID: GC10P096688

cytochrome P450, family 2, subfamily C, polypeptide 9

(Previous names: cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase),...)
(Previous symbol: CYP2C10)

Explore 76 diseases affiliated with
CYP2C9 via

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Cytochrome P450, Family 2, Subfamily C, Polypeptide 9¹ ²		Xenobiotic Monooxygenase²
CYP2C10¹ ² ³		(R)-Limonene 6-Monooxygenase³
P450IIC9¹ ²		(S)-Limonene 6-Monooxygenase³
Cytochrome P-450MP² ³		(S)-Limonene 7-Monooxygenase³
Cytochrome P450 PB-1² ³		EC 1.14.13.-³
CYPIIC9² ³		EC 1.14.13.48³
Cytochrome P450, Subfamily IIC (Mephenytoin 4-Hydroxylase), Polypeptide 9¹		EC 1.14.13.49³
CPC9²		EC 1.14.13.80³
CYP2C²		Cytochrome P450 MP-4³
Cytochrome P-450 S-Mephenytoin 4-Hydroxylase²		Cytochrome P450 MP-8³
Cytochrome P450 2C9²		S-Mephenytoin 4-Hydroxylase³
Flavoprotein-Linked Monooxygenase²		EC 1.14.14.1⁸
Microsomal Monooxygenase²

External Ids:	HGNC: 2623¹	Entrez Gene: 1559²	Ensembl: ENSG00000138109⁷	OMIM: 601130⁵	UniProtKB: P11712³

Export aliases for CYP2C9 gene to outside databases

Previous GC identifers: GC10P095591 GC10P095932 GC10P096829 GC10P096363 GC10P090325

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CYP2C9:

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are

monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and

other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by rifampin. The

enzyme is known to metabolize many xenobiotics, including phenytoin, tolbutamide, ibuprofen and S-warfarin. Studies

identifying individuals who are poor metabolizers of phenytoin and tolbutamide suggest that this gene is polymorphic.

The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CP2C9_HUMAN, P11712

Function: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in

an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including

steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the

metabolism of drugs such as S-warfarin, diclofenac, phenytoin, tolbutamide and losartan

Gene Wiki entry for CYP2C9

PharmGKB "VIP" summary for CYP2C9

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000010.10 NC_018921.1 NT_030059.13

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CYP2C9 gene promoter:
COUP-TF1 COUP HNF-4alpha2 GATA-1 HNF-4alpha1 PPAR-gamma1 COUP-TF HOXA5 PPAR-gamma2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CYP2C9 promoter sequence

Search SABiosciences Chromatin IP Primers for CYP2C9

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CYP2C9

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q24 Ensembl cytogenetic band: 10q23.33 HGNC cytogenetic band: 10q24.1

CYP2C9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CYP2C9 gene location

GeneLoc information about chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10P096688: view genomic region (about GC identifiers)

Start:	96,698,415 bp from pter	End:	96,749,148 bp from pter
Size:	50,734 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CP2C9_HUMAN, P11712 (See protein sequence)

Recommended Name: Cytochrome P450 2C9

Size: 490 amino acids; 55628 Da

Cofactor: Heme group

Subcellular location: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral

membrane protein

3 PDB 3D structures from and Proteopedia for CYP2C9:

1OG2 (3D)

1OG5 (3D)

1R9O (3D)

Secondary accessions: P11713 Q16756 Q16872 Q5VX92

Explore the universe of human proteins at neXtProt for CYP2C9: NX_P11712

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P11712

4/26 DME Specific Peptides for CYP2C9 (P11712) (see all 26)

GKLPPGP

PGPTPLP

PFSAGKR

LTSVLHD

CYP2C9 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_000762.2

ENSEMBL proteins:

ENSP00000260682

Reactome Protein details: P11712
Human Recombinant Protein Products:

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	Uscn Proteins for CYP2C9

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005783	endoplasmic reticulum	NAS	--
GO:0005789	endoplasmic reticulum membrane	TAS	--
GO:0005792	microsome	--	--
GO:0043231	intracellular membrane-bounded organelle	TAS	3032244

CYP2C9 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for CYP2C9

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CYP2C9 for domains About GeneDecksing

3 InterPro domains/families:

IPR001128 Cyt_P450

IPR017972 Cyt_P450_CS

IPR002401 Cyt_P450_E_grp-I

Graphical View of Domain Structure for InterPro Entry P11712

ProtoNet protein and cluster: P11712

2 Blocks protein families:

IPB002401 E-class P450 group I signature

IPB008068 CYP2B P450 family signature

UniProtKB/Swiss-Prot: CP2C9_HUMAN, P11712

Similarity: Belongs to the cytochrome P450 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: CP2C9_HUMAN, P11712

Function: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in

an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including

steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the

metabolism of drugs such as S-warfarin, diclofenac, phenytoin, tolbutamide and losartan

Catalytic activity: (+)-(R)-limonene + NADPH + O(2) = (+)-trans-carveol + NADP(+) + H(2)O

Catalytic activity: (-)-(S)-limonene + NADPH + O(2) = (-)-trans-carveol + NADP(+) + H(2)O

Catalytic activity: (-)-(S)-limonene + NADPH + O(2) = (-)-perillyl alcohol + NADP(+) + H(2)O

Induction: By rifampicin

Genatlas biochemistry entry for CYP2C9:

cytochrome P450,subfamily IIC (mephenytoin 4-hydroxylase),polypeptide 9

Enzyme Numbers (IUBMB): EC 1.14.13.80¹ EC 1.14.14.1² EC 1.14.13.49¹ EC 1.14.13.-¹ EC 1.14.13.48¹

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Gene Editing
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In Situ Assay
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Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for CYP2C9

Gene Ontology (GO): 5/11 molecular function terms (GO ID links to tree view) (see all 11): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004497	monooxygenase activity	NAS	2827463
GO:0005506	iron ion binding	IEA	--
GO:0008144	drug binding	IDA	19448135
GO:0008395	steroid hydroxylase activity	IMP	18356043
GO:0009055	electron carrier activity	IEA	--

CYP2C9 for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/24 super-pathways (see all 24) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Estrone metabolism

Estrone metabolism	1.00	Androstenedione and testosterone biosynthesis and metabolism p.1	0.57
Estrone metabolism	1.00	Estrogen biosynthesis	0.47
Androstenedione and testosterone biosynthesis and metabolism p.1	0.57	Estrogen biosynthesis	0.47

Ifosfamide Pathway, Pharmacokinetics

Ifosfamide Pathway, Pharmacokinetics	1.00	Nevirapine Pathway, Pharmacokinetics	0.50
Cyclophosphamide Pathway, Pharmacokinetics	0.86	Clopidogrel Pathway, Pharmacokinetics	0.36
Sorafenib Pharmacokinetics	0.50	Losartan Pathway, Pharmacokinetics	0.22

Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)

Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)	1.00	Arachidonate Epoxygenase / Epoxide Hydrolase	0.36
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)	0.55	Benzo[a]pyrene metabolism	0.33
Warfarin Pathway, Pharmacokinetics	0.45	Benzo[a]pyrene metabolism	0.33

Arachidonic acid metabolism

	Arachidonic acid metabolism	1.00			HETE and HPETE biosynthesis and metabolism	0.39
	Arachidonic acid metabolism	0.42			HETE and HPETE biosynthesis and metabolism	0.39

Tamoxifen metabolism

	Tamoxifen metabolism	1.00			Estradiol metabolism	0.52
	Tamoxifen Pathway, Pharmacokinetics	0.68			Estradiol metabolism	0.52

Pathway sources
See GeneCards unified pathways
Show all pathways

5/10 EMD Millipore Pathways for CYP2C9 (see all 10)

	Androstenedione and testosterone biosynthesis and metabolism p.1
	Estradiol metabolism
	Retinol metabolism
	Naphthalene metabolism
	Selected targets of GCR-alpha

5/9 GeneGo (Thomson Reuters) Pathways for CYP2C9 (see all 9)

	Estrogen biosynthesis
	HETE and HPETE biosynthesis and metabolism
	Naphthalene metabolism
	Estradiol metabolism
	Retinol metabolism

5 BioSystems Pathways for CYP2C9

	Arachidonate Epoxygenase / Epoxide Hydrolase
	cytochrome P450
	Tamoxifen metabolism
	Nuclear receptors in lipid metabolism and toxicity
	metapathway biotransformation

5/10 Reactome Pathways for CYP2C9 (see all 10)

	Cytochrome P450 - arranged by substrate type
	Xenobiotics
	Metabolism
	Arachidonic acid metabolism
	CYP2E1 reactions

5/22 PharmGKB Pathways for CYP2C9 (see all 22)

	Anti-diabetic Drug Nateglinide Pathway, Pharmacokinetics
	Atorvastatin/Lovastatin/Simvastatin Pathway, Pharmacokinetics
	Caffeine Pathway, Pharmacokinetics
	Celecoxib Pathway, Pharmacokinetics
	Clopidogrel Pathway, Pharmacokinetics

5/6 Kegg Pathways (Kegg details for CYP2C9) (see all 6):

	Arachidonic acid metabolism
	Linoleic acid metabolism
	Retinol metabolism
	Metabolism of xenobiotics by cytochrome P450
	Drug metabolism - cytochrome P450

CYP2C9 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CYP2C9

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/103 Interacting proteins for CYP2C9 (P11712³ ENSP00000260682⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 103)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
RAB3D	O95716³, ENSP00000222120⁴	I2D: score=1 STRING: ENSP00000222120
POR	P16435³	I2D: score=2
CDC37	Q16543³	I2D: score=1
MAST1	Q9Y2H9³	I2D: score=1
RNF32	Q9H0A6³	I2D: score=1

About this table

Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006805	xenobiotic metabolic process	TAS	--
GO:0008202	steroid metabolic process	IMP	18356043
GO:0016098	monoterpenoid metabolic process	IDA	16401082
GO:0017144	drug metabolic process	IMP	--
GO:0019627	urea metabolic process	IDA	19029318

CYP2C9 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CYP2C9 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Enzo Life Sciences drugs & compounds for CYP2C9

Browse Tocris compounds for CYP2C9

10/60 HMDB Compounds for CYP2C9 (see all 60) About this table

Compound	Synonyms	CAS #	PubMed Ids
Melatonin	5-Methoxy-N-acetyltryptamine (see all 23)	73-31-4	20167001
(+)-Limonene	(+)-(4R)-Limonene (see all 2)	5989-27-5	--
(-)-trans-Carveol	Carveol	1197-07-5	--
11,12,15-THETA	11,12,15-Trihydroxyicosatrienoic acid (see all 5)	--	--
11,12-Epoxyeicosatrienoic acid	10-(3-(2-octenyl)oxiranyl)-5,8-Decadienoic acid (see all 15)	81276-02-0	--
11,14,15-THETA	(5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoic acid (see all 8)	--	--
11H-14,15-EETA	14,15-Ep-11-HETrE (see all 11)	219535-29-2	--
12,13-EpOME	Vernolic acid (see all 12)	--	--
13-HETE	13-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoate (see all 2)	151910-72-4	--
14,15-Epoxy-5,8,11-eicosatrienoic acid	(5Z,8Z,11Z)-14,15-Epoxyicosa-5.8.11-trienoic acid (see all 11)	81276-03-1	--

10/264 DrugBank Compounds for CYP2C9 (see all 264) About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Acenocoumarol	Acenocoumarin (see all 7)	152-72-7	enzyme	substrate inhibitor	15790782 18698879 16815313 16869821 16611310 17596133 19934256 19515014
Lornoxicam	Acabel (see all 12)	70374-39-9	enzyme	substrate inhibitor	16118328 15606435 10640513 17022718 19934256 19515014 8857077
Celecoxib	--	169590-42-5	enzyme	substrate	11259318 10749518 19934256 20167001 19515014
Diclofenac	Diclofenac Acid (see all 4)	15307-86-5	enzyme	substrate inhibitor	8417277 12065442 19934256 20167001 19515014
Fluvastatin	Fluindostatin (see all 5)	93957-54-1	enzyme	substrate inhibitor inducer	11368292 19663817 19934256 10064574 19515014
Losartan	DUP 89 (see all 2)	114798-26-4	enzyme	substrate inhibitor	11823761 16029066 10678291 19934256 19515014
Phenytoin	5,5-diphenylhydantoin (see all 13)	57-41-0	enzyme	substrate inhibitor inducer	15805193 8806399 19934256 11038165 19515014
Amitriptyline	Amitriprolidine (see all 7)	50-48-6	enzyme	substrate	11259560 9131945 19934256 19515014
Flurbiprofen	FLP (see all 5)	5104-49-4	enzyme	substrate	11259318 19934256 20167001 19515014
Fosphenytoin	(3-Phosphoryloxymethyl)phenytoin (see all 5)	93390-81-9	enzyme	substrate inducer	19202563 17375979 19515014 11678778

10/151 Novoseek chemical compound relationships for CYP2C9 gene (see all 151) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
vitamin k epoxide	94.4	65	19181737 (2), 17049586 (2), 15790782 (2), 18240910 (1) (see all 43)
s-warfarin	92.6	61	20429590 (6), 16758259 (4), 19679631 (4), 9526963 (3) (see all 28)
sulfaphenazole	92.2	26	10079071 (2), 8857077 (2), 10548450 (1), 15304426 (1) (see all 19)
tolbutamide	89	85	9578596 (6), 8518837 (3), 15325841 (3), 11875364 (3) (see all 49)
warfarin	88.4	351	19077919 (6), 18542936 (5), 17049586 (5), 16413010 (5) (see all 99)
tienilic acid	85	14	7654690 (3), 8905121 (1), 8902272 (1), 9112234 (1) (see all 9)
acenocoumarol	84.7	40	19225451 (4), 16869821 (3), 20020283 (3), 19578179 (2) (see all 23)
furafylline	83.4	2	9431831 (1), 11317475 (1)
androstane	82.2	20	16188404 (2), 12181452 (2), 20167002 (1), 12815172 (1) (see all 11)
diclofenac	80.2	67	11829203 (6), 12534640 (5), 15135088 (2), 15486075 (2) (see all 41)

10/17 PharmGKB related drug/compound annotations for CYP2C9 gene (see all 17)

Drug/compound	PharmGKB Annotation
"Antiinflammatory agents, non-steroids"	CA
"sulfonamides, urea derivatives"	CA
acenocoumarol	CA DG
celecoxib	CA DL
diclofenac	CA
flurbiprofen	DL
fluvoxamine	DL
glibenclamide	DG
gliclazide	DG
glimepiride	DG

About this table

Search CenterWatch for drugs/clinical trials and news about CYP2C9 / CP2C9

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CYP2C9 gene:

NM_000771.3

Unigene Cluster for CYP2C9:

Cytochrome P450, family 2, subfamily C, polypeptide 9

Hs.282624 [show with all ESTs]

Unigene Representative Sequence: NM_000771

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000461906(uc001kjz.3) ENST00000260682(uc001kka.4 uc009xut.3)

ENST00000473496

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Additional cDNA sequence:

AK289420.1 AK298458.1 BC020754.1 BC070317.1 BC125054.1 D00173.1 M15331.1 M21939.1

M21940.1 M61855.1 M61857.1 S46963.1

12 DOTS entries:

DT.442309 DT.92457811 DT.92457774 DT.121303397 DT.92034871 DT.92457778 DT.95168915 DT.92457798

DT.121303420 DT.92457789 DT.91802519 DT.92457782

24/175 AceView cDNA sequences (see all 175):

C21133 AV648351 AV647944 AV646374 AV655841 AV651935 AV651958 AV661295

BG198890 AV661210 AV655432 CB163889 CB162071 AV658509 AV661281 AV651928

AV660643 AV659393 CB161481 AV649415 CB162668 CB148958 AV645499 BG569544

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for CYP2C9 About this scheme

ExUns:	1a	·	1b	·	1c	^	2a	·	2b	^	3a	·	3b	^	4	^	5a	·	5b	^	6	^	7	^	8	^	9
SP1:													-						-
SP2:													-						-		-
SP3:													-
SP4:

ECgene alternative splicing isoforms for CYP2C9

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CYP2C9 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

CYP2C9 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Liver

Liver Lobule

Perivenous Hepatocytes

Liver

Liver Lobule

Mature Hepatocytes

Liver

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See CYP2C9 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CYP2C9

SOURCE GeneReport for Unigene cluster: Hs.282624

SABiosciences Expression via Pathway-Focused PCR Arrays including CYP2C9 (see all 6):

Nephrotoxicity in human mouse rat

Cancer Drug Resistance in human mouse rat

Drug Metabolism: Phase I Enzymes in human mouse rat

Cellular Stress Responses in human mouse rat

Molecular Toxicology PathwayFinder 384HT in human mouse rat

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CYP2C9 gene from 3/10 species (see all 10) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	CYP2C45¹	cytochrome P-450 2C45	63.57(n) 58.14(a)		414833 NM_001001752.1 NP_001001752.1
lizard (Anolis carolinensis)	Reptilia	-- -- (see all 17)	--	57(a) 57(a) (see all 17)	many ↔ many many ↔ many (see all 17)	1(16287752-16303321) GL343274.1(1290564-1308168)
zebrafish (Danio rerio)	Actinopterygii	cyp2y3⁶ CU928854.1⁶	--	48(a) 47(a)	many ↔ many many ↔ many	15(65144-71354) 15(54297-58832)

ENSEMBL Gene Tree for CYP2C9 (if available)
TreeFam Gene Tree for CYP2C9 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CYP2C9 gene

CYP2W1² CYP2C8² CYP2F1² CYP2A7² CYP2R1² CYP2U1² CYP2J2² CYP2E1²

CYP2D6² CYP2B7P1² CYP2A6² CYP2B6² CYP2C19² CYP2S1² CYP2C18² CYP2A13²

18/38 SIMAP similar genes for CYP2C9 using alignment to 6 protein entries: CP2C9_HUMAN (see all proteins) (see all similar genes):

CYP2C19 CYP 2C CYP2C18 CYP2C DKFZp686I24235 CYP2C8

CYP2E1 CYP2G1P CYP2A13 CYP2A6 CYP2B CYP2B7

CYP2A7 CYP2A6V2 CYP2B6 CYP2F1 CYP2S1 CYP2W1

CYP2C9 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for CYP2C9
PGOHUM00000238611

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 10 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs1057910^1,2	C,F,H,	pathogenic	97872183(+)	`GATACA/CTTGAC`	2	I L	mis¹		41		MN NS EA NA EU	11706
rs72558191^1,2	C	pathogenic	97905287(+)	`AGATTG/TTGAGC`	2	V L	mis¹		0	--	--	--	--
rs72558189^1,2	C	untested	97910972(+)	`CCGGCA/GTTTCT`	2	H R	mis¹		0	--	--	--	--
rs72558187^1,2	C,	untested	97911248(+)	`TGATCC/TTGGAG`	2	P L	mis¹		0	--	--	--	--
rs1799853^1,2	C,F,H,	other	97910916(+)	`AGGACC/TGTGTT`	2	R C	mis¹ ese³		24		MN NS NA EA EU	9812
rs9332092^1,2	C,F,H,	--	90323207(+)	`AGTTAT/CTGCTT`	1	--	us2k¹ tfbs³		29		NS MN EA WA NA	4374
rs9332093^1,2	C,F,H,	--	90323233(+)	`AAAGGC/GTTCTC`	1	--	us2k¹		23		NS EA NA CSA	2742
rs9332094^1,2	C,F,H,	--	90323352(+)	`GAAAAT/CAATTT`	1	--	us2k¹ tfbs³		8		NS EA NA WA CSA	586
rs9332095^1,2	C,H,	--	90323521(+)	`taagaT/Cactga`	1	--	us2k¹		5		NS EA	580
rs61604699^1,2	C,F,	--	90323581(+)	`AAGCAG/AAGGTA`	1	--	us2k¹		18		MN WA EA CSA NA	2940

HapMap Linkage Disequilibrium report for CYP2C9 (96698415 - 96749148 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CYP2C9: --
Human Gene Mutation Database (HGMD): CYP2C9

Locus Specific Mutation Databases (LSDB): CYP2C9

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CYP2C9

DNA2.0 Custom Variant and Variant Library Synthesis for CYP2C9

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CYP2C9 for disorders           About GeneDecksing

OMIM gene information: 601130
OMIM disorders: 122700
20/76 diseases for CYP2C9 (see all 76):    About MalaCards

tolbutamide poor metabolizer sudden infant death syndrome drug-induced hepatitis deep vein thrombosis

patent ductus arteriosus portal vein thrombosis lichen planus oral lichen planus

warfarin sensitivity back pain cholesterol non-hodgkin lymphoma

type 2 diabetes mellitus major depressive disorder myocardial infarction warfarin resistance

gingival overgrowth polycystic ovary syndrome essential tremor atrial fibrillation

10/23 Novoseek disease relationships for CYP2C9 gene (see all 23) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
bleeding	42.8	51	14707031 (3), 18756910 (3), 17681167 (3), 20362363 (3) (see all 27)
thromboembolism	26.1	1	18542936 (1)
genetic susceptibility	25	1	17681167 (1)
hepatitis autoimmune	16.8	1	8700140 (1)
renal failure chronic	5.62	1	12732848 (1)
schizophrenia	3.17	1	10813809 (1)
necrosis	2.29	3	8232220 (1), 17576808 (1), 19448967 (1)
tumors	0.11	11	14759713 (3), 8232220 (1), 10991840 (1), 19448967 (1) (see all 6)
astrocytoma	0	1	16188404 (1)
stroke	0	4	17049586 (1), 20073138 (1), 18788834 (1)

Genetic Association Database (GAD): CYP2C9
Human Genome Epidemiology (HuGE) Navigator: CYP2C9 (553 documents)

Export disorders for CYP2C9 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CYP2C9 gene, integrated from 9 sources (see all 1178):
(articles sorted by number of sources associating them with CYP2C9)

Utopia: connect your pdf to the dynamic
world of online information

Lornoxicam pharmacokinetics in relation to cytochrome P450 2C9 genotype. (PubMed id 15606435)^{1, 4, 7, 9} Zhang Y....Zhou H. (2005)
Contributions of CYP2D6, CYP2C9 and CYP2C19 to the biotransformation of E- and Z-doxepin in healthy volunteers. (PubMed id 12360109)^{1, 4, 7} Kirchheiner J....Brockmoller J. (2002)
Association between CYP2C9 genetic variants and anticoagulation- related outcomes during warfarin therapy. (PubMed id 11926893)^{1, 2, 4} Higashi M.K.... Rettie A.E. (2002)
CYP2C9, CYP2C19, ABCB1 (MDR1) genetic polymorphisms and phenytoin metabolism in a Black Beninese population. (PubMed id 16220110)^{1, 4, 9} Allabi A.C....Horsmans Y. (2005)
The impact of CYP2C9 genetics and oral contraceptives on cytochrome P450 2C9 phenotype. (PubMed id 15100169)^{1, 4, 9} Sandberg M....Eliasson E. (2004)
Regulation of cytochrome P450 2C9 expression in primary cultures of human hepatocytes. (PubMed id 19202563)^{1, 7, 9} Sahi J....LeCluyse E.L. (2009)
Is cytochrome P450 2C9 genotype associated with NSAID gastric ulceration? (PubMed id 11422024)^{1, 4, 9} Martin J.H....Barclay M.L. (2001)
CYP2C9 genetic variants and losartan oxidation in a Turkish population. (PubMed id 15197523)^{1, 4, 9} Babaoglu M.O....Bozkurt A. (2004)
[Association between genetic polymorphisms of CYP2C19 and CYP2C9 and phenytoin serum concentration] (PubMed id 15569425)^{1, 4, 9} Huang Y....Chen B. (2004)
Rapid detection of the known SNPs of CYP2C9 using oligonucleotide microarray. (PubMed id 12800253)^{1, 4, 9} Wen S.Y....Wang S.Q. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 1559	HGNC: 2623	AceView: CYP2C9	Ensembl:ENSG00000138109	euGenes: HUgn1559
ECgene: CYP2C9	Kegg: 1559	H-InvDB: CYP2C9

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CYP2C9	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for CYP2C9	Genetics and Cytogenetics in Oncology and Haematology
Cytochrome P450 Allele Nomenclature Committee	http://www.cypalleles.ki.se/cyp2c9.htm
NIEHS-SNPs	http://egp.gs.washington.edu/data/cyp2c9/

Intellectual Property for CYP2C9 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for CYP2C9 gene:
Search GeneIP for patents involving CYP2C9

GeneCards and IP:
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CYP2C9 Gene

cytochrome P450, family 2, subfamily C, polypeptide 9

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CYP2C9 (Gene Symbol)
Cytochrome P450, Family 2, Subfamily C, Polypeptide 9
CYP2C10
P450IIC9
Cytochrome P-450MP
Cytochrome P450 PB-1
CYPIIC9
Cytochrome P450, Subfamily IIC (Mephenytoin 4-Hydroxylase), Polypeptide 9
CPC9
CYP2C
Cytochrome P-450 S-Mephenytoin 4-Hydroxylase
Cytochrome P450 2C9
Flavoprotein-Linked Monooxygenase
Microsomal Monooxygenase
Xenobiotic Monooxygenase
(R)-Limonene 6-Monooxygenase
(S)-Limonene 6-Monooxygenase
(S)-Limonene 7-Monooxygenase
EC 1.14.13.-
EC 1.14.13.48
EC 1.14.13.49
EC 1.14.13.80
Cytochrome P450 MP-4
Cytochrome P450 MP-8
S-Mephenytoin 4-Hydroxylase
EC 1.14.14.1

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CYP2C9 Gene

cytochrome P450, family 2, subfamily C, polypeptide 9

Aliasesfor CYP2C9 gene

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