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CYP2C9 Gene

protein-coding   GIFtS: 68
GCID: GC10P096688

Cytochrome P450, Family 2, Subfamily C, Polypeptide 9

(Previous names: cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase),...)
(Previous symbol: CYP2C10)
  See CYP2C9-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cytochrome P450, Family 2, Subfamily C, Polypeptide 91 2     Xenobiotic Monooxygenase2
CYP2C101 2 3     (R)-Limonene 6-Monooxygenase3
Cytochrome P-450MP2 3     (S)-Limonene 6-Monooxygenase3
Cytochrome P450 PB-12 3     (S)-Limonene 7-Monooxygenase3
CYPIIC92 3     EC 1.14.13.-3
Cytochrome P450, Subfamily IIC (Mephenytoin 4-Hydroxylase), Polypeptide 91     EC 1.14.13.483
CPC92     EC 1.14.13.493
CYP2C2     EC 1.14.13.803
P450IIC92     Cytochrome P450 MP-43
Cytochrome P-450 S-Mephenytoin 4-Hydroxylase2     Cytochrome P450 MP-83
Cytochrome P450 2C92     S-Mephenytoin 4-Hydroxylase3
Flavoprotein-Linked Monooxygenase2     EC 1.14.14.18
Microsomal Monooxygenase2     

External Ids:    HGNC: 26231   Entrez Gene: 15592   Ensembl: ENSG000001381097   OMIM: 6011305   UniProtKB: P117123   

Export aliases for CYP2C9 gene to outside databases

Previous GC identifers: GC10P095591 GC10P095932 GC10P096829 GC10P096363 GC10P090325


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CYP2C9 Gene:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are
monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids
and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by rifampin.
The enzyme is known to metabolize many xenobiotics, including phenytoin, tolbutamide, ibuprofen and S-warfarin.
Studies identifying individuals who are poor metabolizers of phenytoin and tolbutamide suggest that this gene is
polymorphic. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. (provided by
RefSeq, Jul 2008)

GeneCards Summary for CYP2C9 Gene:
CYP2C9 (cytochrome P450, family 2, subfamily C, polypeptide 9) is a protein-coding gene. Diseases associated with CYP2C9 include warfarin sensitivity, and tolbutamide poor metabolizer. GO annotations related to this gene include electron carrier activity and heme binding. An important paralog of this gene is CYP2W1.

UniProtKB/Swiss-Prot: CP2C9_HUMAN, P11712
Function: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is
involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated
compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics
variability of the metabolism of drugs such as S-warfarin, diclofenac, phenytoin, tolbutamide and losartan

Gene Wiki entry for CYP2C9 Gene

PharmGKB "VIP" summary for CYP2C9


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NT_030059.14  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CYP2C9 gene promoter:
         COUP-TF1   COUP   HNF-4alpha2   GATA-1   HNF-4alpha1   PPAR-gamma1   COUP-TF   HOXA5   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CYP2C9 promoter sequence
   Search Chromatin IP Primers for CYP2C9

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CYP2C9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q24   Ensembl cytogenetic band:  10q23.33   HGNC cytogenetic band: 10q24.1

CYP2C9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CYP2C9 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P096688:  view genomic region     (about GC identifiers)

Start:
96,698,415 bp from pter      End:
96,749,148 bp from pter
Size:
50,734 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CP2C9_HUMAN, P11712 (See protein sequence)
Recommended Name: Cytochrome P450 2C9  
Size: 490 amino acids; 55628 Da
Cofactor: Heme group
3 PDB 3D structures from and Proteopedia for CYP2C9:
1OG2 (3D)        1OG5 (3D)        1R9O (3D)    
Secondary accessions: P11713 Q16756 Q16872 Q5VX92

Explore the universe of human proteins at neXtProt for CYP2C9: NX_P11712

Explore proteomics data for CYP2C9 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for CYP2C9 (P11712) (see all 26)
     GKLPPGP  PGPTPLP  PFSAGKR  LTSVLHD 


    See CYP2C9 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000762.2  
    ENSEMBL proteins: 
     ENSP00000260682  
    Reactome Protein details: P11712

    CYP2C9 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CYP: Cytochrome P450s

    IUPHAR Guide to PHARMACOLOGY protein family classification: CYP2C9
    CYP2 family

    3 InterPro protein domains:
     IPR001128 Cyt_P450
     IPR017972 Cyt_P450_CS
     IPR002401 Cyt_P450_E_grp-I

    Graphical View of Domain Structure for InterPro Entry P11712

    ProtoNet protein and cluster: P11712

    2 Blocks protein domains:
    IPB002401 E-class P450 group I signature
    IPB008068 CYP2B P450 family signature


    UniProtKB/Swiss-Prot: CP2C9_HUMAN, P11712
    Similarity: Belongs to the cytochrome P450 family


    Find genes that share domains with CYP2C9           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CP2C9_HUMAN, P11712
    Function: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is
    involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated
    compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics
    variability of the metabolism of drugs such as S-warfarin, diclofenac, phenytoin, tolbutamide and losartan
    Catalytic activity: (+)-(R)-limonene + NADPH + O(2) = (+)-trans-carveol + NADP(+) + H(2)O
    Catalytic activity: (-)-(S)-limonene + NADPH + O(2) = (-)-trans-carveol + NADP(+) + H(2)O
    Catalytic activity: (-)-(S)-limonene + NADPH + O(2) = (-)-perillyl alcohol + NADP(+) + H(2)O
    Induction: By rifampicin

         Genatlas biochemistry entry for CYP2C9:
    cytochrome P450,subfamily IIC (mephenytoin 4-hydroxylase),polypeptide 9

         Enzyme Numbers (IUBMB): EC 1.14.13.801 EC 1.14.14.12 EC 1.14.13.491 EC 1.14.13.-1 EC 1.14.13.481

         Gene Ontology (GO): Selected molecular function terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004497monooxygenase activity NAS2827463
    GO:0005506iron ion binding IEA--
    GO:0008144drug binding IDA19448135
    GO:0008395steroid hydroxylase activity IMP18356043
    GO:0016491oxidoreductase activity IDA16401082
         
    Find genes that share ontologies with CYP2C9           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for CYP2C9

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CP2C9_HUMAN, P11712: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral
    membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    cytosol2
    nucleus2
    extracellular1
    mitochondrion1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum ----
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0043231intracellular membrane-bounded organelle TAS2827463

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    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CYP2C9 About   (see all 19)  
    See pathways by source

    SuperPathContained pathways About
    1Cytochrome P450 - arranged by substrate type
    Cytochrome P450 - arranged by substrate type0.75
    Cyclophosphamide Pathway, Pharmacokinetics0.00
    Phase 1 - Functionalization of compounds0.75
    Ifosfamide Pathway, Pharmacokinetics0.00
    cytochrome P4500.74
    Vitamin D2 ergocalciferol metabolism0.00
    Xenobiotics0.00
    CYP2E1 reactions0.00
    2Biological oxidations
    Biological oxidations0.56
    Sorafenib Pharmacokinetics0.00
    metapathway biotransformation0.42
    Tamoxifen metabolism0.00
    Phenytoin Pathway, Pharmacokinetics0.00
    Estradiol metabolism0.00
    Tamoxifen Pathway, Pharmacokinetics0.00
    3Arachidonic acid metabolism
    Linoleic acid metabolism0.64
    HETE and HPETE biosynthesis and metabolism0.33
    Arachidonic acid metabolism0.41
    Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)0.00
    Arachidonic acid metabolism0.40
    Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)0.00
    4Chemical carcinogenesis
    Chemical carcinogenesis0.71
    Retinol metabolism0.35
    Metabolism of xenobiotics by cytochrome P4500.71
    Benzo a pyrene metabolism0.00
    Drug metabolism - cytochrome P4500.69
    Celecoxib Pathway, Pharmacokinetics0.00
    5Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    Metabolic pathways0.38


    Find genes that share SuperPaths with CYP2C9           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    Selected GeneGo (Thomson Reuters) Pathways for CYP2C9 (see all 9)
        Estrogen biosynthesis
    HETE and HPETE biosynthesis and metabolism
    Naphthalene metabolism
    Estradiol metabolism
    Retinol metabolism

    5 BioSystems Pathways for CYP2C9
        cytochrome P450
    Arachidonate Epoxygenase / Epoxide Hydrolase
    Tamoxifen metabolism
    Nuclear receptors in lipid metabolism and toxicity
    metapathway biotransformation

    4 Reactome Pathways for CYP2C9
        Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)
    Xenobiotics
    Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)
    CYP2E1 reactions

    Selected PharmGKB Pathways for CYP2C9 (see all 23)
        Anti-diabetic Drug Nateglinide Pathway, Pharmacokinetics
    Atorvastatin/Lovastatin/Simvastatin Pathway, Pharmacokinetics
    Caffeine Pathway, Pharmacokinetics
    Celecoxib Pathway, Pharmacokinetics
    Clopidogrel Pathway, Pharmacokinetics

    Selected Kegg Pathways  (Kegg details for CYP2C9) (see all 8):
        Arachidonic acid metabolism
    Linoleic acid metabolism
    Retinol metabolism
    Metabolism of xenobiotics by cytochrome P450
    Drug metabolism - cytochrome P450

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CYP2C9 (see all 6): 
              Nephrotoxicity in human mouse rat
              Cancer Drug Resistance in human mouse rat
              Drug Metabolism: Phase I Enzymes in human mouse rat
              Cellular Stress Responses in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CYP2C9

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CYP2C9 (P117123 ENSP000002606824) via UniProtKB, MINT, STRING, and/or I2D (see all 103)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RAB3DO957163, ENSP000002221204I2D: score=1 STRING: ENSP00000222120
    PORP164353I2D: score=2 
    CDC37Q165433I2D: score=1 
    MAST1Q9Y2H93I2D: score=1 
    RNF32Q9H0A63I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006805xenobiotic metabolic process TAS--
    GO:0008202steroid metabolic process IMP18356043
    GO:0016098monoterpenoid metabolic process IDA16401082
    GO:0017144drug metabolic process IMP--
    GO:0019369arachidonic acid metabolic process TAS--

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    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for CYP2C9
      Browse compounds at ApexBio 

    Browse Tocris compounds for CYP2C9 (CP2C9)

    Selected HMDB Compounds for CYP2C9 (see all 60)    About this table
    CompoundSynonyms CAS #PubMed Ids
    Melatonin5-Methoxy-N-acetyltryptamine (see all 23)73-31-420167001
    (+)-Limonene(+)-(4R)-Limonene (see all 2)5989-27-5--
    (-)-trans-CarveolCarveol 1197-07-5--
    11,12,15-THETA11,12,15-Trihydroxyicosatrienoic acid (see all 5)----
    11,12-Epoxyeicosatrienoic acid10-(3-(2-octenyl)oxiranyl)-5,8-Decadienoic acid (see all 15)81276-02-0--
    11,14,15-THETA(5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoic acid (see all 8)----
    11H-14,15-EETA14,15-Ep-11-HETrE (see all 11)219535-29-2--
    12,13-EpOMEVernolic acid (see all 12)----
    13-HETE13-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoate (see all 2)151910-72-4--
    14,15-Epoxy-5,8,11-eicosatrienoic acid(5Z,8Z,11Z)-14,15-Epoxyicosa-5.8.11-trienoic acid (see all 11)81276-03-1--

    Selected DrugBank Compounds for CYP2C9 (see all 275)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    AcenocoumarolAcenocoumarin (see all 7)152-72-7enzymesubstrate inhibitor15790782 18698879 16815313 16869821 16611310 17596133 19934256 19515014
    LornoxicamAcabel (see all 12)70374-39-9enzymesubstrate inhibitor16118328 15606435 10640513 17022718 19934256 19515014 8857077
    Celecoxib-- 169590-42-5enzymesubstrate11259318 10749518 19934256 20167001 19515014
    DiclofenacDiclofenac Acid (see all 4)15307-86-5enzymesubstrate inhibitor8417277 12065442 19934256 20167001 19515014
    Fluvastatin-- 93957-54-1enzymesubstrate inhibitor inducer11368292 19663817 19934256 10064574 19515014
    LosartanDuP 89 (see all 2)114798-26-4enzymesubstrate inhibitor11823761 16029066 10678291 19934256 19515014
    Phenytoin5,5-diphenylhydantoin (see all 13)57-41-0enzymesubstrate inhibitor inducer15805193 8806399 19934256 11038165 19515014
    AmitriptylineAmitriprolidine (see all 5)50-48-6enzymesubstrate11259560 9131945 19934256 19515014
    FlurbiprofenFLP (see all 5)5104-49-4enzymesubstrate11259318 19934256 20167001 19515014
    Fosphenytoin(3-Phosphoryloxymethyl)phenytoin (see all 5)93390-81-9enzymesubstrate inducer19202563 17375979 19515014 11678778

    Selected Novoseek inferred chemical compound relationships for CYP2C9 gene (see all 151)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    vitamin k epoxide 94.4 65 19181737 (2), 17049586 (2), 15790782 (2), 18240910 (1) (see all 43)
    s-warfarin 92.6 61 20429590 (6), 16758259 (4), 19679631 (4), 9526963 (3) (see all 28)
    sulfaphenazole 92.2 26 10079071 (2), 8857077 (2), 10548450 (1), 15304426 (1) (see all 19)
    tolbutamide 89 85 9578596 (6), 8518837 (3), 15325841 (3), 11875364 (3) (see all 49)
    warfarin 88.4 351 19077919 (6), 18542936 (5), 17049586 (5), 16413010 (5) (see all 99)
    tienilic acid 85 14 7654690 (3), 8905121 (1), 8902272 (1), 9112234 (1) (see all 9)
    acenocoumarol 84.7 40 19225451 (4), 16869821 (3), 20020283 (3), 19578179 (2) (see all 23)
    furafylline 83.4 2 9431831 (1), 11317475 (1)
    androstane 82.2 20 16188404 (2), 12181452 (2), 20167002 (1), 12815172 (1) (see all 11)
    diclofenac 80.2 67 11829203 (6), 12534640 (5), 15135088 (2), 15486075 (2) (see all 41)

    Selected PharmGKB related drug/compound annotations for CYP2C9 gene (see all 50)    About this table
    Drug/compound PharmGKB Annotation
    Antiinflammatory agents, non-steroidsCA  
    sulfonamides, urea derivativesCA  
    acenocoumarol  CA  
    anastrozole
    capecitabine
    carvedilol
    celecoxib  CA  
    citalopram
    clobazam
    clopidogrel  CA  



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    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CYP2C9 gene: 
    NM_000771.3  

    Unigene Cluster for CYP2C9:

    Cytochrome P450, family 2, subfamily C, polypeptide 9
    Hs.282624  [show with all ESTs]
    Unigene Representative Sequence: NM_000771
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000461906(uc001kjz.3) ENST00000260682(uc001kka.4 uc009xut.3)
    ENST00000473496
    miRNA
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      QuantiFast Probe-based Assays in human, mouse, rat CYP2C9

    Additional mRNA sequence: 

    AK289420.1 AK298458.1 BC020754.1 BC070317.1 BC125054.1 D00173.1 M15331.1 M21939.1 
    M21940.1 M61855.1 M61857.1 S46963.1 

    12 DOTS entries:

    DT.442309  DT.92457811  DT.92457774  DT.121303397  DT.92034871  DT.92457778  DT.95168915  DT.92457798 
    DT.121303420  DT.92457789  DT.91802519  DT.92457782 

    Selected AceView cDNA sequences (see all 175):

    AV659393 AV658509 AV659109 AV661295 BG198890 CB148984 AV651614 S46963 
    AV655841 AV660643 AV651587 AV649200 AV646374 AV655432 M61857 BG569544 
    AV651922 AV651935 AV649420 AV651928 BC020754 AV649415 T54023 AV647944 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for CYP2C9    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9
    SP1:                                      -                 -                           
    SP2:                                      -                 -     -                     
    SP3:                                      -                                             
    SP4:                                                                                    


    ECgene alternative splicing isoforms for CYP2C9

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    CYP2C9 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CYP2C9 Expression
    About this image


    CYP2C9 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Liver (Hepatobiliary System)    fully expand to see all 3 entries
             Mature Hepatocytes Liver Lobule
     
     Heart (Cardiovascular System)
             Atrioventricular Node
     
     Amnion (Extraembryonic Tissues)
             Amniotic Epithelial Cells Amniotic Membrane
     
     Colon (Gastrointestinal Tract)
    CYP2C9 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CYP2C9 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.282624
        Pathway & Disease-focused RT2 Profiler PCR Arrays including CYP2C9 (see all 6): 
              Nephrotoxicity in human mouse rat
              Cancer Drug Resistance in human mouse rat
              Drug Metabolism: Phase I Enzymes in human mouse rat
              Cellular Stress Responses in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for CYP2C9 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cyp2c555
    Cyp2c661
    cytochrome P450, family 2, subfamily c, polypeptide more1, 5 80.54(n)1
    76.01(a)1
      19 (33.64 cM)5
    698881  NM_001011707.11  NP_001011707.11 
     390070195 


    ENSEMBL Gene Tree for CYP2C9 (if available)
    TreeFam Gene Tree for CYP2C9 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CYP2C9 gene
    CYP2W12  CYP2C82  CYP2A62  CYP2F12  CYP2A72  CYP2B62  CYP2C192  CYP2R12  
    CYP2J22  CYP2U12  CYP2S12  CYP2E12  CYP2D62  CYP2C182  CYP2A132  
    Selected SIMAP similar genes for CYP2C9 using alignment to 12 protein entries:     CP2C9_HUMAN (see all proteins) (see all similar genes):
    CYP2C19    CYP 2C    CYP2C18    CYP2C    CYP2C8    CYP2E1
    DKFZp686I24235    CYP2G1P    CYP2A13    CYP2A6    CYP2B7    CYP2B
    CYP2A6V2    CYP2A7    CYP2F1    CYP2S1    CYP2B6    CYP2W1

    Find genes that share paralogs with CYP2C9           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for CYP2C9
    PGOHUM00000238611


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CYP2C9 (see all 1422)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs725581911,2
    Cpathogenic197070876(+) AGATTG/TTGAGC 2 V L mis10--------
    rs10579101,2,,4
    C,F,Hpathogenic197104254(+) GATACA/CTTGAC 2 I L mis141Minor allele frequency- C:0.04MN NS EA NA EU 11706
    rs725581871,2
    Cuntested197064915(+) TGATCC/TTGGAG 2 P L mis10--------
    rs725581891,2
    Cuntested197065191(+) CCGGCA/GTTTCT 2 H R mis10--------
    rs17998531,2,,4
    C,F,Hother197065247(+) AGGACC/TGTGTT 2 R C mis1 ese324Minor allele frequency- T:0.10MN NS NA EA EU 9812
    rs2010228581,2
    --90360703(+) TTGTT-/TTGTTTTT 1 -- cds10--------
    rs114565101,2
    C--90360704(+) TGTTT-/T/TG  
            
    TTTTT
    1 -- int1 trp30--------
    rs1441016081,2
    C--90362518(+) TTTAA-/TTTTTT 1 -- int10--------
    rs93320991,2
    C,F--96697800(+) tttttT/-aggGG 1 -- us2k11Minor allele frequency- -:0.04NS 154
    rs756458491,2
    C--96698970(+) TCTTTT/GTTCCC 1 -- int13Minor allele frequency- G:0.06CSA NA EA 242

    HapMap Linkage Disequilibrium report for CYP2C9 (96698415 - 96749148 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for CYP2C9:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2739707CNV Deletion23290073
    esv2674280CNV Deletion23128226
    esv2741937CNV Deletion23290073
    nsv7497CNV Insertion18451855

    The Human Cytochrome P450 Allele Nomenclature Database: CYP2C9 
    Human Gene Mutation Database (HGMD): CYP2C9
    Locus Specific Mutation Databases (LSDB): CYP2C9

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CYP2C9
    DNA2.0 Custom Variant and Variant Library Synthesis for CYP2C9

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601130   
    OMIM disorders: 122700  
    6 diseases for CYP2C9:    
    About MalaCards
    warfarin sensitivity    tolbutamide poor metabolizer    diffuse alveolar hemorrhage    warfarin resistance
    drug-induced hepatitis    multiple chemical sensitivity


    Find genes that share disorders with CYP2C9           About GenesLikeMe

    Selected Novoseek inferred disease relationships for CYP2C9 gene (see all 23)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    bleeding 42.8 51 14707031 (3), 18756910 (3), 17681167 (3), 20362363 (3) (see all 27)
    thromboembolism 26.1 1 18542936 (1)
    genetic susceptibility 25 1 17681167 (1)
    hepatitis autoimmune 16.8 1 8700140 (1)
    renal failure chronic 5.62 1 12732848 (1)
    schizophrenia 3.17 1 10813809 (1)
    necrosis 2.29 3 8232220 (1), 17576808 (1), 19448967 (1)
    tumors 0.11 11 14759713 (3), 8232220 (1), 10991840 (1), 19448967 (1) (see all 6)
    astrocytoma 0 1 16188404 (1)
    stroke 0 4 17049586 (1), 20073138 (1), 18788834 (1)

    Genetic Association Database (GAD): CYP2C9
    Human Genome Epidemiology (HuGE) Navigator: CYP2C9 (553 documents)

    Export disorders for CYP2C9 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CYP2C9 gene, integrated from 10 sources (see all 1236):
    (articles sorted by number of sources associating them with CYP2C9)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Lornoxicam pharmacokinetics in relation to cytochrome P450 2C9 genotype. (PubMed id 15606435)1, 4, 7, 9 Zhang Y....Zhou H. (Br J Clin Pharmacol 2005)
    2. Pharmacogenetics of oral anticoagulants: a basis for dose individualization. (PubMed id 18698879)1, 4, 7, 9 Stehle S....Fuhr U. (Clin Pharmacokinet 2008)
    3. The risk of myocardial infarction in patients with reduced activity of cytochrome P450 2C9. (PubMed id 17558303)1, 4, 7, 9 Visser L.E....Stricker B.H. (Pharmacogenet. Genomics 2007)
    4. The genetic interaction between VKORC1 c1173t and calumenin a29809g modulates the anticoagulant response of acenocoumarol. (PubMed id 17596133)1, 4, 7 GonzA!lez-Conejero R....Vicente V. (J. Thromb. Haemost. 2007)
    5. VKORC1 and CYP2C9 genotypes and phenprocoumon anticoagulation status: interaction between both genotypes affects dose requirement. (PubMed id 17192772)1, 4, 7 Schalekamp T....de Boer A. (Clin. Pharmacol. Ther. 2007)
    6. VKORC1 and CYP2C9 genotypes and acenocoumarol anticoagulation status: interaction between both genotypes affects overanticoagulation. (PubMed id 16815313)1, 4, 7 Schalekamp T....de Boer A. (Clin. Pharmacol. Ther. 2006)
    7. Contributions of CYP2D6, CYP2C9 and CYP2C19 to the biotransformation of E- and Z-doxepin in healthy volunteers. (PubMed id 12360109)1, 4, 7 Kirchheiner J....BrockmAPller J. (Pharmacogenetics 2002)
    8. Association between CYP2C9 genetic variants and anticoagulation- related outcomes during warfarin therapy. (PubMed id 11926893)1, 2, 4 Higashi M.K.... Rettie A.E. (JAMA 2002)
    9. Genetic susceptibility to nonsteroidal anti-inflammatory drug-related gastroduodenal bleeding: role of cytochrome P450 2C9 polymorphisms. (PubMed id 17681167)1, 4, 9 Pilotto A....Dallapiccola B. (Gastroenterology 2007)
    10. CYP2C9, CYP2C19, ABCB1 (MDR1) genetic polymorphisms and phenytoin metabolism in a Black Beninese population. (PubMed id 16220110)1, 4, 9 Allabi A.C....Horsmans Y. (Pharmacogenet. Genomics 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1559 HGNC: 2623 AceView: CYP2C9 Ensembl:ENSG00000138109 euGenes: HUgn1559
    ECgene: CYP2C9 Kegg: 1559 H-InvDB: CYP2C9

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CYP2C9 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CYP2C9 Genetics and Cytogenetics in Oncology and Haematology
    Cytochrome P450 Allele Nomenclature Committeehttp://www.cypalleles.ki.se/cyp2c9.htm
    NIEHS-SNPshttp://egp.gs.washington.edu/data/cyp2c9/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CYP2C9 gene:
    Search GeneIP for patents involving CYP2C9

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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