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Aliases for CYP2C9 Gene

Aliases for CYP2C9 Gene

  • Cytochrome P450, Family 2, Subfamily C, Polypeptide 9 2 3
  • Cytochrome P450 PB-1 3 4
  • Cytochrome P-450MP 3 4
  • CYP2C10 3 4
  • CYPIIC9 3 4
  • Cytochrome P450, Subfamily IIC (Mephenytoin 4-Hydroxylase), Polypeptide 9 2
  • Cytochrome P-450 S-Mephenytoin 4-Hydroxylase 3
  • Flavoprotein-Linked Monooxygenase 3
  • (R)-Limonene 6-Monooxygenase 4
  • (S)-Limonene 6-Monooxygenase 4
  • (S)-Limonene 7-Monooxygenase 4
  • S-Mephenytoin 4-Hydroxylase 4
  • Microsomal Monooxygenase 3
  • Xenobiotic Monooxygenase 3
  • Cytochrome P450 MP-4 4
  • Cytochrome P450 MP-8 4
  • Cytochrome P450 2C9 3
  • EC 1.14.13.80 4
  • EC 1.14.13.48 4
  • EC 1.14.13.49 4
  • EC 1.14.14.1 63
  • EC 1.14.13.- 4
  • P450IIC9 3
  • CYP2C 3
  • CPC9 3

External Ids for CYP2C9 Gene

Previous Symbols for CYP2C9 Gene

  • CYP2C10

Summaries for CYP2C9 Gene

Entrez Gene Summary for CYP2C9 Gene

  • This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by rifampin. The enzyme is known to metabolize many xenobiotics, including phenytoin, tolbutamide, ibuprofen and S-warfarin. Studies identifying individuals who are poor metabolizers of phenytoin and tolbutamide suggest that this gene is polymorphic. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. [provided by RefSeq, Jul 2008]

GeneCards Summary for CYP2C9 Gene

CYP2C9 (Cytochrome P450, Family 2, Subfamily C, Polypeptide 9) is a Protein Coding gene. Diseases associated with CYP2C9 include oral antidiabetic drugs toxicity or dose selection and vitamin k antagonists toxicity or dose selection. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include electron carrier activity and heme binding. An important paralog of this gene is CYP2C19.

UniProtKB/Swiss-Prot for CYP2C9 Gene

  • Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenytoin, tolbutamide and losartan

Gene Wiki entry for CYP2C9 Gene

PharmGKB "VIP" Summary for CYP2C9 Gene

No data available for Tocris Summary , fRNAdb sequence ontologies and piRNA Summary for CYP2C9 Gene

Genomics for CYP2C9 Gene

Genomic Location for CYP2C9 Gene

Start:
94,938,593 bp from pter
End:
94,989,391 bp from pter
Size:
50,799 bases
Orientation:
Plus strand

Genomic View for CYP2C9 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CYP2C9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYP2C9 Gene

Regulatory Elements for CYP2C9 Gene

Proteins for CYP2C9 Gene

  • Protein details for CYP2C9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P11712-CP2C9_HUMAN
    Recommended name:
    Cytochrome P450 2C9
    Protein Accession:
    P11712
    Secondary Accessions:
    • P11713
    • Q16756
    • Q16872
    • Q5VX92
    • Q6IRV8
    • Q8WW80

    Protein attributes for CYP2C9 Gene

    Size:
    490 amino acids
    Molecular mass:
    55628 Da
    Cofactor:
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CYP2C9 Gene

    Alternative splice isoforms for CYP2C9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CYP2C9 Gene

Proteomics data for CYP2C9 Gene at MOPED

Post-translational modifications for CYP2C9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CYP2C9 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for CYP2C9 Gene

Gene Families for CYP2C9 Gene

HGNC:
  • CYP :Cytochrome P450s
IUPHAR :

Protein Domains for CYP2C9 Gene

Graphical View of Domain Structure for InterPro Entry

P11712

UniProtKB/Swiss-Prot:

CP2C9_HUMAN
Family:
  • Belongs to the cytochrome P450 family.:
    • P11712
genes like me logo Genes that share domains with CYP2C9: view

Function for CYP2C9 Gene

Molecular function for CYP2C9 Gene

GENATLAS Biochemistry: cytochrome P450,subfamily IIC (mephenytoin 4-hydroxylase),polypeptide 9
UniProtKB/Swiss-Prot CatalyticActivity: (+)-(R)-limonene + NADPH + O(2) = (+)-trans-carveol + NADP(+) + H(2)O
UniProtKB/Swiss-Prot CatalyticActivity: (-)-(S)-limonene + NADPH + O(2) = (-)-trans-carveol + NADP(+) + H(2)O
UniProtKB/Swiss-Prot CatalyticActivity: (-)-(S)-limonene + NADPH + O(2) = (-)-perillyl alcohol + NADP(+) + H(2)O
UniProtKB/Swiss-Prot Function: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenytoin, tolbutamide and losartan
UniProtKB/Swiss-Prot Induction: By rifampicin

Enzyme Numbers (IUBMB) for CYP2C9 Gene

Gene Ontology (GO) - Molecular Function for CYP2C9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004497 monooxygenase activity NAS 2827463
GO:0005506 iron ion binding IEA --
GO:0008144 drug binding IDA 19448135
GO:0008392 arachidonic acid epoxygenase activity IBA --
GO:0008395 steroid hydroxylase activity IMP 18356043
genes like me logo Genes that share ontologies with CYP2C9: view

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CYP2C9 Gene

Localization for CYP2C9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYP2C9 Gene

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CYP2C9 Gene COMPARTMENTS Subcellular localization image for CYP2C9 gene
Compartment Confidence
endoplasmic reticulum 5
cytosol 2
nucleus 2
extracellular 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CYP2C9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0043231 intracellular membrane-bounded organelle TAS 2827463
genes like me logo Genes that share ontologies with CYP2C9: view

Pathways for CYP2C9 Gene

SuperPathways for CYP2C9 Gene

genes like me logo Genes that share pathways with CYP2C9: view

Gene Ontology (GO) - Biological Process for CYP2C9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006805 xenobiotic metabolic process TAS --
GO:0008202 steroid metabolic process IMP 18356043
GO:0016098 monoterpenoid metabolic process IDA 16401082
GO:0017144 drug metabolic process IMP 21127708
GO:0019369 arachidonic acid metabolic process TAS --
genes like me logo Genes that share ontologies with CYP2C9: view

Compounds for CYP2C9 Gene

(60) HMDB Compounds for CYP2C9 Gene

Compound Synonyms Cas Number PubMed IDs
(-)-trans-Carveol
  • Carveol
1197-07-5
(+)-Limonene
  • (+)-(4R)-Limonene
5989-27-5
11,12,15-THETA
  • 11,12,15-Trihydroxyicosatrienoic acid
Not Available
11,12-Epoxyeicosatrienoic acid
  • 10-(3-(2-octenyl)oxiranyl)-5,8-Decadienoic acid
81276-02-0
11,14,15-THETA
  • (5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoic acid
Not Available

(276) Drugbank Compounds for CYP2C9 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
4-Hydroxy-3-[(1s)-3-Oxo-1-Phenylbutyl]-2h-Chromen-2-One
target
4-Hydroxy-3-[(1s)-3-Oxo-1-Phenylbutyl]-2h-Chromen-2-One
enzyme
Acenocoumarol
  • Acenocoumarin
152-72-7 enzyme substrate inhibitor
Acetaminophen
  • Acetaminofen
103-90-2 enzyme substrate
Acetylsalicylic acid
  • 2-Acetoxybenzenecarboxylic acid
50-78-2 enzyme substrate

(151) Novoseek inferred chemical compound relationships for CYP2C9 Gene

Compound -log(P) Hits PubMed IDs
vitamin k epoxide 94.4 46
s-warfarin 92.6 43
sulfaphenazole 92.2 21
tolbutamide 89 63
warfarin 88.4 227
genes like me logo Genes that share compounds with CYP2C9: view

Transcripts for CYP2C9 Gene

mRNA/cDNA for CYP2C9 Gene

Unigene Clusters for CYP2C9 Gene

Cytochrome P450, family 2, subfamily C, polypeptide 9:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CYP2C9 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9
SP1: - -
SP2: - - -
SP3: -
SP4:

Relevant External Links for CYP2C9 Gene

GeneLoc Exon Structure for
CYP2C9
ECgene alternative splicing isoforms for
CYP2C9

Expression for CYP2C9 Gene

mRNA expression in normal human tissues for CYP2C9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CYP2C9 Gene

This gene is overexpressed in Liver (49.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CYP2C9 Gene

SOURCE GeneReport for Unigene cluster for CYP2C9 Gene Hs.282624

genes like me logo Genes that share expressions with CYP2C9: view

No data available for mRNA Expression by UniProt/SwissProt for CYP2C9 Gene

Orthologs for CYP2C9 Gene

This gene was present in the common ancestor of animals.

Orthologs for CYP2C9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CYP2C9 36
  • 99 (a)
OneToOne
LOC100616515 35
  • 99.46 (n)
  • 99.39 (a)
cow
(Bos Taurus)
Mammalia -- 36
  • 77 (a)
ManyToMany
-- 36
  • 79 (a)
ManyToMany
CYP2C18 36
  • 78 (a)
ManyToMany
CYP2C87 36
  • 78 (a)
ManyToMany
LOC505468 35
  • 83.79 (n)
  • 78.77 (a)
mouse
(Mus musculus)
Mammalia Cyp2c29 36
  • 76 (a)
ManyToMany
Cyp2c37 36
  • 73 (a)
ManyToMany
Cyp2c38 36
  • 72 (a)
ManyToMany
Cyp2c39 36
  • 73 (a)
ManyToMany
Cyp2c40 36
  • 63 (a)
ManyToMany
Cyp2c50 36
  • 73 (a)
ManyToMany
Cyp2c54 36
  • 71 (a)
ManyToMany
Cyp2c55 16
Cyp2c65 36
  • 76 (a)
ManyToMany
Cyp2c66 35
  • 80.54 (n)
  • 76.01 (a)
Cyp2c66 36
  • 76 (a)
ManyToMany
Cyp2c67 36
  • 67 (a)
ManyToMany
Cyp2c68 36
  • 66 (a)
ManyToMany
Cyp2c69 36
  • 67 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 67 (a)
ManyToMany
-- 36
  • 64 (a)
ManyToMany
-- 36
  • 67 (a)
ManyToMany
-- 36
  • 65 (a)
ManyToMany
-- 36
  • 68 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Cyp2c11 35
  • 80.75 (n)
  • 76.22 (a)
fruit fly
(Drosophila melanogaster)
Insecta Cyp18a1 37
  • 32 (a)
Cyp303a1 37
  • 26 (a)
worm
(Caenorhabditis elegans)
Secernentea F14H3.10 37
  • 30 (a)
B0213.12 37
  • 33 (a)
C41G6.1 37
  • 31 (a)
F41B5.2 37
  • 31 (a)
T10H4.11 37
  • 32 (a)
Y5H2B.6 37
  • 28 (a)
F42A9.5 37
  • 34 (a)
C45H4.2 37
  • 31 (a)
Y49C4A.9 37
  • 32 (a)
B0213.16 37
  • 29 (a)
F41B5.7 37
  • 32 (a)
K09A11.3 37
  • 32 (a)
C49C8.4 37
  • 32 (a)
C34B7.3 37
  • 31 (a)
B0213.10 37
  • 32 (a)
B0213.14 37
  • 33 (a)
C25E10.2 37
  • 28 (a)
F41B5.3 37
  • 33 (a)
K07C6.2 37
  • 29 (a)
K09D9.2 37
  • 30 (a)
C12D5.7 37
  • 33 (a)
K07C6.5 37
  • 29 (a)
F44C8.1 37
  • 32 (a)
C49G7.8 37
  • 29 (a)
B0304.3 37
  • 31 (a)
B0213.15 37
  • 30 (a)
C03G6.15 37
  • 29 (a)
F41B5.4 37
  • 31 (a)
R08F11.3 37
  • 29 (a)
T09H2.1 37
  • 31 (a)
C45H4.17 37
  • 31 (a)
K07C6.3 37
  • 29 (a)
T10H4.10 37
  • 31 (a)
Species with no ortholog for CYP2C9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for CYP2C9 Gene

ENSEMBL:
Gene Tree for CYP2C9 (if available)
TreeFam:
Gene Tree for CYP2C9 (if available)

Paralogs for CYP2C9 Gene

Pseudogenes.org Pseudogenes for CYP2C9 Gene

genes like me logo Genes that share paralogs with CYP2C9: view

Variants for CYP2C9 Gene

Sequence variations from dbSNP and Humsavar for CYP2C9 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs602082 -- 94,945,771(-) tgatg(A/G)tgagc intron-variant
rs602084 -- 94,945,769(-) atggt(A/G)agcat intron-variant
rs1057909 - 94,981,294(+) GAGAT(A/G)CMTTG reference, missense
rs1057910 drug-response, - 94,981,296(+) GATAC(A/C)TTGAC reference, missense
rs1057911 -- 94,988,980(+) AATGG(A/T)TTTGC reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for CYP2C9 Gene

Variant ID Type Subtype PubMed ID
esv2739707 CNV Deletion 23290073
esv2674280 CNV Deletion 23128226
esv2741937 CNV Deletion 23290073
nsv7497 CNV Insertion 18451855

Relevant External Links for CYP2C9 Gene

HapMap Linkage Disequilibrium report
CYP2C9
Human Gene Mutation Database (HGMD)
CYP2C9
Locus Specific Mutation Databases (LSDB)
CYP2C9
The Human Cytochrome P450 Allele Nomenclature Database
CYP2C9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CYP2C9 Gene

Disorders for CYP2C9 Gene

(1) OMIM Diseases for CYP2C9 Gene (601130)

(23) Novoseek inferred disease relationships for CYP2C9 Gene

Disease -log(P) Hits PubMed IDs
bleeding 42.8 41
thromboembolism 26.1 1
genetic susceptibility 25 1
hepatitis autoimmune 16.8 1
renal failure chronic 5.62 1

Relevant External Links for CYP2C9

Genetic Association Database (GAD)
CYP2C9
Human Genome Epidemiology (HuGE) Navigator
CYP2C9
genes like me logo Genes that share disorders with CYP2C9: view

No data available for UniProtKB/Swiss-Prot for CYP2C9 Gene

Publications for CYP2C9 Gene

  1. Lornoxicam pharmacokinetics in relation to cytochrome P450 2C9 genotype. (PMID: 15606435) Zhang Y. … Zhou H. (Br J Clin Pharmacol 2005) 3 23 25 48
  2. The risk of myocardial infarction in patients with reduced activity of cytochrome P450 2C9. (PMID: 17558303) Visser L.E. … Stricker B.H. (Pharmacogenet. Genomics 2007) 3 23 25 48
  3. Pharmacogenetics of oral anticoagulants: a basis for dose individualization. (PMID: 18698879) Stehle S. … Fuhr U. (Clin Pharmacokinet 2008) 3 23 25 48
  4. Six-base deletion occurring in messages of human cytochrome P-450 in the CYP2C subfamily results in reduction of tolbutamide hydroxylase activity. (PMID: 1445376) Ohgiya S. … Kamataki T. (Biochem. Int. 1992) 3 4 23
  5. Allelic and functional variability of cytochrome P4502C9. (PMID: 9110362) Bhasker C.R. … Birkett D.J. (Pharmacogenetics 1997) 3 4 23

Products for CYP2C9 Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Cancer Drug Resistance in human,mouse,rat
    • Cellular Stress Responses in human,mouse,rat
    • Drug Metabolism in human,mouse,rat
    • Drug Metabolism: Phase I Enzymes in human,mouse,rat
    • Molecular Toxicology PathwayFinder 384HT in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate CYP2C9
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for CYP2C9
    • Block miRNA regulation of CYP2C9 using miScript Target Protectors

    Sources for CYP2C9 Gene

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