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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CYP2C8 Gene

protein-coding GIFtS: 69
GCID: GC10M096786

cytochrome P450, family 2, subfamily C, polypeptide 8

(Previous names: cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase),...)

Explore 35 diseases affiliated with
CYP2C8 via

MalaCards

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Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Cytochrome P450, Family 2, Subfamily C, Polypeptide 8¹ ²		CYPIIC8² ³
CPC8¹ ²		EC 1.14.14.1³ ⁸
Cytochrome P450, Subfamily IIC (Mephenytoin 4-Hydroxylase), Polypeptide 8¹ ²		MP-12/MP-20²
Cytochrome P450 Form 1² ³		Cytochrome P450 2C8²
Cytochrome P450 IIC2² ³		Flavoprotein-Linked Monooxygenase²
Cytochrome P450 MP-12² ³		Microsomal Monooxygenase²
Cytochrome P450 MP-20² ³		P450 Form 1²
S-Mephenytoin 4-Hydroxylase² ³		Xenobiotic Monooxygenase²

External Ids:	HGNC: 2622¹	Entrez Gene: 1558²	Ensembl: ENSG00000138115⁷	OMIM: 601129⁵	UniProtKB: P10632³

Export aliases for CYP2C8 gene to outside databases

Previous GC identifers: GC10M095689 GC10M096030 GC10M096927 GC10M096461 GC10M090423

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CYP2C8:

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are

monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and

other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The

enzyme is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, benzo(a)pyrene,

7-ethyoxycoumarin, and the anti-cancer drug taxol. This gene is located within a cluster of cytochrome P450 genes on

chromosome 10q24. Several transcript variants encoding a few different isoforms have been found for this gene.

(provided by RefSeq, Nov 2010)

UniProtKB/Swiss-Prot: CP2C8_HUMAN, P10632

Function: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in

an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including

steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it generates only 14,15- and

11,12-cis-epoxyeicosatrienoic acids. It is the principal enzyme responsible for the metabolism the anti-cancer drug

paclitaxel (taxol)

Gene Wiki entry for CYP2C8

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000010.10 NC_018921.1 NT_030059.13

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CYP2C8 gene promoter:
GR p300 GR-beta HNF-4alpha1 HNF-1A AREB6 HNF-1 GR-alpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CYP2C8 promoter sequence

Search SABiosciences Chromatin IP Primers for CYP2C8

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CYP2C8

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q23.33 Ensembl cytogenetic band: 10q23.33 HGNC cytogenetic band: 10q24.1

CYP2C8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CYP2C8 gene location

GeneLoc information about chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10M096786: view genomic region (about GC identifiers)

Start:	96,796,529 bp from pter	End:	96,829,254 bp from pter
Size:	32,726 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CP2C8_HUMAN, P10632 (See protein sequence)

Recommended Name: Cytochrome P450 2C8

Size: 490 amino acids; 55825 Da

Cofactor: Heme group

Subcellular location: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral

membrane protein

Caution: Alternative splicing has been shown to occur but the shorter forms are believed to be non-functional

5 PDB 3D structures from and Proteopedia for CYP2C8:

1PQ2 (3D)

2NNH (3D)

2NNI (3D)

2NNJ (3D)

2VN0 (3D)

Secondary accessions: A8K9N8 B0AZN2 B7Z1F6 Q5VX93 Q8WWB1 Q9UCZ9

Alternative splicing: 2 isoforms: P10632-1 P10632-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CYP2C8: NX_P10632

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P10632

4/32 DME Specific Peptides for CYP2C8 (P10632) (see all 32)

PFSAGKR

PGPTPLP

VIGRHRS

LTSVLHD

CYP2C8 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (4 alternative transcripts):

NP_000761.3 NP_001185782.1 NP_001185783.1 NP_001185784.1

ENSEMBL proteins:

ENSP00000433191 ENSP00000433314 ENSP00000360317 ENSP00000432934 ENSP00000433842

ENSP00000445062 ENSP00000442343

Reactome Protein details: P10632
Human Recombinant Protein Products:

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	Uscn Proteins for CYP2C8

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005783	endoplasmic reticulum	NAS	--
GO:0005789	endoplasmic reticulum membrane	TAS	--
GO:0005792	microsome	--	--

CYP2C8 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for CYP2C8

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CYP2C8 for domains About GeneDecksing

3 InterPro domains/families:

IPR001128 Cyt_P450

IPR017972 Cyt_P450_CS

IPR002401 Cyt_P450_E_grp-I

Graphical View of Domain Structure for InterPro Entry P10632

ProtoNet protein and cluster: P10632

1 Blocks protein family: IPB002401 E-class P450 group I signature

UniProtKB/Swiss-Prot: CP2C8_HUMAN, P10632

Similarity: Belongs to the cytochrome P450 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: CP2C8_HUMAN, P10632

Function: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in

an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including

steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it generates only 14,15- and

11,12-cis-epoxyeicosatrienoic acids. It is the principal enzyme responsible for the metabolism the anti-cancer drug

paclitaxel (taxol)

Catalytic activity: RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O

Induction: By phenobarbital

Genatlas biochemistry entry for CYP2C8:

cytochrome P450,subfamily IIC (mephenytoin 4-hydroxylase),polypeptide 8

Enzyme Number (IUBMB): EC 1.14.14.1¹ ²

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Gene Editing
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYP2C8

Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004497	monooxygenase activity	IDA	19651758
GO:0005506	iron ion binding	IEA	--
GO:0009055	electron carrier activity	IEA	--
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	--	--
GO:0020037	heme binding	IEA	--

CYP2C8 for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/20 super-pathways (see all 20) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)

Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)	1.00	Arachidonate Epoxygenase / Epoxide Hydrolase	0.36
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)	0.55	Benzo[a]pyrene metabolism	0.33
Warfarin Pathway, Pharmacokinetics	0.45	Benzo[a]pyrene metabolism	0.33
Amodiaquine Pathway, Pharmacokinetics	0.38

Xenobiotics

	Xenobiotics	1.00			Phenytoin Pathway, Pharmacokinetics	0.42
	CYP2E1 reactions	0.65			Carbamazepine Pathway, Pharmacokinetics	0.38

Arachidonic acid metabolism

	Arachidonic acid metabolism	1.00			HETE and HPETE biosynthesis and metabolism	0.39
	Arachidonic acid metabolism	0.42			HETE and HPETE biosynthesis and metabolism	0.39

Cytochrome P450 - arranged by substrate type

	Cytochrome P450 - arranged by substrate type	1.00			cytochrome P450	0.73
	Phase 1 - Functionalization of compounds	0.74

Metabolism

	Metabolism	1.00			Metabolism of lipids and lipoproteins	0.34
	Metabolic pathways	0.38

Pathway sources
See GeneCards unified pathways
Show all pathways

5/8 EMD Millipore Pathways for CYP2C8 (see all 8)

	Estradiol metabolism
	Retinol metabolism
	Development Alpha-2 adrenergic receptor activation of ERK
	Naphthalene metabolism
	Selected targets of GCR-alpha

5/7 GeneGo (Thomson Reuters) Pathways for CYP2C8 (see all 7)

	Estrogen biosynthesis
	Estradiol metabolism
	Retinol metabolism
	HETE and HPETE biosynthesis and metabolism
	Naphthalene metabolism

4 BioSystems Pathways for CYP2C8

	Arachidonate Epoxygenase / Epoxide Hydrolase
	cytochrome P450
	Tamoxifen metabolism
	metapathway biotransformation

5/10 Reactome Pathways for CYP2C8 (see all 10)

	Cytochrome P450 - arranged by substrate type
	Xenobiotics
	Metabolism
	Arachidonic acid metabolism
	CYP2E1 reactions

5/16 PharmGKB Pathways for CYP2C8 (see all 16)

	Amodiaquine Pathway, Pharmacokinetics
	Anti-diabetic Drug Repaglinide Pathway, Pharmacokinetics
	Atorvastatin/Lovastatin/Simvastatin Pathway, Pharmacokinetics
	Caffeine Pathway, Pharmacokinetics
	Carbamazepine Pathway, Pharmacokinetics

5/6 Kegg Pathways (Kegg details for CYP2C8) (see all 6):

	Arachidonic acid metabolism
	Linoleic acid metabolism
	Retinol metabolism
	Metabolism of xenobiotics by cytochrome P450
	Drug metabolism - cytochrome P450

CYP2C8 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CYP2C8

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/104 Interacting proteins for CYP2C8 (P10632³ ENSP00000360317⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 104)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
A2M	P01023³	I2D: score=1
APOE	P02649³	I2D: score=1
BLMH	Q13867³	I2D: score=1
DNAJB1	P25685³	I2D: score=1
GABARAPL1	Q9H0R8³	I2D: score=1

About this table

Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006082	organic acid metabolic process	IDA	19651758
GO:0006805	xenobiotic metabolic process	TAS	--
GO:0017144	drug metabolic process	IDA	19651758
GO:0042738	exogenous drug catabolic process	IDA	18619574
GO:0044281	small molecule metabolic process	TAS	--

CYP2C8 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CYP2C8 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CYP2C8

10/53 HMDB Compounds for CYP2C8 (see all 53) About this table

Compound	Synonyms	CAS #	PubMed Ids
10-HETE	10-hydroxyeicosa-all-cis-5,8,11,14-tetraenoate (see all 2)	167697-52-1	--
11,12,15-THETA	11,12,15-Trihydroxyicosatrienoic acid (see all 5)	--	--
11,12-Epoxyeicosatrienoic acid	10-(3-(2-octenyl)oxiranyl)-5,8-Decadienoic acid (see all 15)	81276-02-0	--
11,14,15-THETA	(5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoic acid (see all 8)	--	--
11H-14,15-EETA	14,15-Ep-11-HETrE (see all 11)	219535-29-2	--
11beta-Hydroxytestosterone	11beta,17beta-dihydroxyandrost-4-en-3-one	1816-85-9	--
12,13-EpOME	Vernolic acid (see all 12)	--	--
13-HETE	13-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoate (see all 2)	151910-72-4	--
14,15-Epoxy-5,8,11-eicosatrienoic acid	(5Z,8Z,11Z)-14,15-Epoxyicosa-5.8.11-trienoic acid (see all 11)	81276-03-1	--
15(S)-HPETE	(5Z,8Z,11Z,13E)-(15S)-15-Hydroperoxyicosa-5,8,11,13-tetraenoate (see all 8)	70981-96-3	--

10/166 DrugBank Compounds for CYP2C8 (see all 166) About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Fluvastatin	Fluindostatin (see all 5)	93957-54-1	enzyme	substrate inhibitor	11368292 19663817 19934256 10064574 19515014
Pioglitazone	Pioglitazona [INN-Spanish] (see all 5)	111025-46-8	enzyme	substrate inhibitor	16867170 12642470 19614891 19934256 19515014
Cerivastatin	Cerivastatin sodium (see all 2)	145599-86-6	enzyme	substrate inhibitor	17178259 12433802 19934256 19515014
Simvastatin	Simvastatin [Usan:Ban:Inn] (see all 4)	79902-63-9	enzyme	substrate inhibitor	17178259 15601807 15998357 19934256
Amiodarone	Amiodarona [INN-Spanish] (see all 5)	1951-25-3	enzyme	substrate	11038157 19934256 19515014
Amodiaquine	Amodiaquin (see all 4)	86-42-0	enzyme	substrate	11805197 15155557 19934256
Felodipine	Dl-Felodipine (see all 4)	72509-76-3	enzyme	inhibitor	18413310 15601807 19934256
Lovastatin	6 alpha-Methylcompactin (see all 4)	75330-75-5	enzyme	inhibitor	15601807 15998357 19934256
Montelukast	--	158966-92-8	enzyme	inhibitor	18413310 15601807 19934256
Repaglinide	AG-EE 388 ZW (see all 4)	135062-02-1	enzyme	substrate	19934256 12919179 19515014

10/45 Novoseek chemical compound relationships for CYP2C8 gene (see all 45) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
androstane	82.4	3	15933212 (2), 20214592 (1)
sulfaphenazole	80.5	2	15581350 (1)
cerivastatin	74.6	12	12433802 (2), 15716363 (2), 20214592 (2), 15601807 (1) (see all 6)
paclitaxel	73.7	50	16753005 (5), 15655291 (5), 15716363 (4), 16299241 (4) (see all 20)
amodiaquine	72.2	6	15155557 (1), 20126327 (1), 18255358 (1), 20214592 (1)
tolbutamide	71	4	9522439 (1), 15155557 (1), 9578596 (1), 9660842 (1)
repaglinide	71	5	14534525 (2), 15601807 (1), 19761371 (1), 17923851 (1)
ketoconazole	68.5	1	18653741 (1)
phenacetin	68.3	3	15155557 (1), 9929510 (1), 17954527 (1)
chlorzoxazone	63.8	1	15155557 (1)

8 PharmGKB related drug/compound annotations for CYP2C8 gene

Drug/compound	PharmGKB Annotation
Bisphosphonates	CA
amodiaquine	CA
paclitaxel	CA
pamidronate	CA
repaglinide	CA
rosiglitazone	CA
zoledronate	CA

About this table

Search CenterWatch for drugs/clinical trials and news about CYP2C8 / CP2C8

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CYP2C8 gene (5 alternative transcripts):

NM_000770.3 NM_001198853.1 NM_001198854.1 NM_001198855.1 NM_030878.1

Unigene Cluster for CYP2C8:

Cytochrome P450, family 2, subfamily C, polypeptide 8

Hs.709188 [show with all ESTs]

Unigene Representative Sequence: CD013969

13 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000527420 ENST00000490994(uc010qoa.2 uc010qoc.2) ENST00000371270(uc001kkb.3)

ENST00000526814(uc010qob.2) ENST00000527953(uc001kkc.3 uc010qod.1)

ENST00000526880(uc021pwl.1) ENST00000533320 ENST00000525991 ENST00000531714

ENST00000479946 ENST00000527488 ENST00000535898 ENST00000539050

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Additional cDNA sequence:

AK292753.1 AK293327.1 AK293328.1 AK298401.1 AK303813.1 AK315823.1 BC020596.1 M17397.1

M21941.1 M21942.1 X51535.1 Y00498.1

19 DOTS entries:

DT.314630 DT.121226273 DT.92457795 DT.121226258 DT.101984878 DT.92457781 DT.92457771 DT.101984879

DT.100705262 DT.101984876 DT.100798511 DT.92457791 DT.95290702 DT.100798514 DT.121226275 DT.75119896

DT.86858862 DT.95236230 DT.92014702

24/124 AceView cDNA sequences (see all 124):

BE773755 AV653304 AV645956 CB157029 CB154252 BP343375 AV649270 AA709270

AV661290 AV681651 CD013968 AV719071 CD013967 CB154182 CB155995 CD013969

BX118253 CB115644 BX646320 CB154352 CD014119 BU735810 CB164724 CB164329

GeneLoc Exon Structure

5/10 Alternative Splicing Database (ASD) splice patterns (SP) for CYP2C8 (see all 10) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	^	2	^	3	^	4a	·	4b	^	5a	·	5b	·	5c	^	6	^	7	^	8	^	9	^	10a	·	10b	^	11a	·	11b
SP1:									-		-																						-
SP2:																															-		-
SP3:									-		-																				-		-
SP4:									-		-																						-
SP5:									-		-																				-		-

ECgene alternative splicing isoforms for CYP2C8

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CYP2C8 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAGCTATTTT

About this image

CYP2C8 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Liver

Liver Lobule

Perivenous Hepatocytes

Liver

Liver Lobule

Mature Hepatocytes

Liver

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Hepatocytes (Primary Cell)

Liver

See CYP2C8 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CYP2C8

SOURCE GeneReport for Unigene cluster: Hs.709188

SABiosciences Expression via Pathway-Focused PCR Arrays including CYP2C8:

Cancer Drug Resistance in human mouse rat

Drug Metabolism: Phase I Enzymes in human mouse rat

Drug Metabolism in human mouse rat

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CYP2C8 gene from 4/12 species (see all 12) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	CYP2H1¹	cytochrome P450 2H1	63.43(n) 56.61(a)		414746 NM_001001616.1 NP_001001616.1
lizard (Anolis carolinensis)	Reptilia	-- -- (see all 17)	--	61(a) 59(a) (see all 17)	many ↔ many many ↔ many (see all 17)	AAWZ02038902(823-8873) 1(16287752-16303321)
African clawed frog (Xenopus laevis)	Amphibia	BC045126.1²	--	73.72(n)		BC045126.1
zebrafish (Danio rerio)	Actinopterygii	BC044463.1²	--	72.49(n)		393108 BC044463.1

ENSEMBL Gene Tree for CYP2C8 (if available)
TreeFam Gene Tree for CYP2C8 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CYP2C8 gene

CYP2W1² CYP2F1² CYP2A7² CYP2R1² CYP2U1² CYP2J2² CYP2E1² CYP2D6²

CYP2B7P1² CYP2A6² CYP2B6² CYP2C19² CYP2S1² CYP2C9² CYP2C18² CYP2A13²

18/30 SIMAP similar genes for CYP2C8 using alignment to 6 protein entries: CP2C8_HUMAN (see all proteins) (see all similar genes):

CYP 2C CYP2C19 CYP2C18 CYP2C9 CYP2C CYP2E1

CYP2G1P CYP2A13 CYP2A6 CYP2A6V2 CYP2A7 CYP2B

CYP2B7 CYP2F1 CYP2B6 DKFZp686I24235 CYP2S1 CYP2R1

CYP2C8 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for CYP2C8
PGOHUM00000241006

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 10 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs80283032^1,2		--	90422953(+)	`CTCTAG/CATGAC`	4	--	ds500¹		1		WA	118
rs28399518^1,2	C,	--	90423361(-)	`CTGACC/TTCTCA`	4	--	ut3¹ ese³		0	--	--	--	--
rs11572178^1,2	C,H	--	90423657(-)	`AGTAAC/TTACTT`	4	--	int¹		7		NS EA NA	598
rs10882519^1,2	C,F,	--	90423723(+)	`ATATGA/C/TAGTAA`	4	--	int¹		5		NS WA CSA	306
rs11572177^1,2	C,F,H,	--	90423835(-)	`AATATA/GTCTCT`	4	--	int¹		27		NS EA NA WA CSA	3190
rs11572176^1,2	C,F,H,	--	90424012(-)	`TGGAAC/TAGGAA`	4	--	int¹		18		NS EA NA WA	2024
rs75321477^1,2	C,	--	90424046(+)	`CTTCCA/GCTTTT`	4	--	int¹		0	--	--	--	--
rs1934952^1,2	C,F,O,H,	--	90424065(-)	`GCTGAG/AAACAG`	4	--	int¹		36		NS NA EA WA CSA	3492
rs11572175^1,2	C,F,	--	90424132(-)	`ACAACA/CGGATA`	4	--	int¹		1		NS	160
rs11572174^1,2	C,F,H,	--	90424136(-)	`ATGAAC/TAACAG`	4	--	int¹		17		NS EA NA	1788

HapMap Linkage Disequilibrium report for CYP2C8 (96796529 - 96829254 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CYP2C8: --
Human Gene Mutation Database (HGMD): CYP2C8

Locus Specific Mutation Databases (LSDB): CYP2C8

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CYP2C8

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CYP2C8 for disorders           About GeneDecksing

OMIM gene information: 601129    OMIM disorders: --

20/35 diseases for CYP2C8 (see all 35):    About MalaCards

rhabdomyolysis, cerivastatin-induced cholesterol essential tremor myocardial infarction

acute myocardial infarction fatty liver disease esophageal squamous cell carcinoma squamous cell carcinoma

coronary heart disease gilbert syndrome tremor chronic lymphocytic leukemia

epithelial ovarian cancer lymphocytic leukemia liver disease osteonecrosis

multiple myeloma ovarian cancer kidney disease myeloma

2 diseases from the University of Copenhagen DISEASES database for CYP2C8:

Osteonecrosis Malaria

2 Novoseek disease relationships for CYP2C8 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tumors	0.922	3	14759713 (2)
cancer	0	1	17558302 (1)

Genetic Association Database (GAD): CYP2C8
Human Genome Epidemiology (HuGE) Navigator: CYP2C8 (106 documents)

Export disorders for CYP2C8 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CYP2C8 gene, integrated from 9 sources (see all 296):
(articles sorted by number of sources associating them with CYP2C8)

Utopia: connect your pdf to the dynamic
world of online information

Determinants of cytochrome P450 2C8 substrate binding: structures of complexes with montelukast, troglitazone, felodipine, and 9-cis-retinoic acid. (PubMed id 18413310)^{1, 2, 7, 9} Schoch G.A....Johnson E.F. (2008)
Structure of human microsomal cytochrome P450 2C8. Evidence for a peripheral fatty acid binding site. (PubMed id 14676196)^{1, 2, 7, 9} Schoch G.A....Johnson E.F. (2004)
Polymorphisms in human CYP2C8 decrease metabolism of the anticancer drug paclitaxel and arachidonic acid. (PubMed id 11668219)^{1, 2, 4} Dai D.... Goldstein J.A. (2001)
Association of CYP2C8, CYP3A4, CYP3A5, and ABCB1 polymorphisms with the pharmacokinetics of paclitaxel. (PubMed id 16299241)^{1, 4, 9} Henningsson A....McLeod H.L. (2005)
The effect of the cytochrome P450 CYP2C8 polymorphism on the disposition of (R)-ibuprofen enantiomer in healthy subjects. (PubMed id 15606441)^{1, 4, 9} Martinez C....Agundez J.A. (2005)
Interindividual variability in ibuprofen pharmacokinetics is related to interaction of cytochrome P450 2C8 and 2C9 amino acid polymorphisms. (PubMed id 15289789)^{1, 4, 9} Garcia-Martin E....Agundez J.A. (2004)
A simple multiplex PCR method for the concurrent detection of three CYP2C8 variants. (PubMed id 15469873)^{1, 4, 9} Muthiah Y.D....Ismail R. (2004)
Polymorphism in CYP2C8 is associated with reduced plasma concentrations of repaglinide. (PubMed id 14534525)^{1, 4, 9} Niemi M....Neuvonen P.J. (2003)
Allelic variants of cytochromes P450 2C modify the risk for acute myocardial infarction. (PubMed id 14646690)^{1, 4, 9} Yasar U....Rane A. (2003)
Single nucleotide polymorphisms in the CYP2J2 and CYP2C8 genes and the risk of hypertension. (PubMed id 15864120)^{1, 4, 9} King L.M....Zeldin D.C. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 1558	HGNC: 2622	AceView: CYP2C8	Ensembl:ENSG00000138115	euGenes: HUgn1558
ECgene: CYP2C8	Kegg: 1558	H-InvDB: CYP2C8

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CYP2C8	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for CYP2C8	Genetics and Cytogenetics in Oncology and Haematology
Cytochrome P450 Allele Nomenclature Committee	http://www.cypalleles.ki.se/cyp2c8.htm
NIEHS-SNPs	http://egp.gs.washington.edu/data/cyp2c8/

Intellectual Property for CYP2C8 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for CYP2C8 gene:
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GeneCards and IP:
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CYP2C8 Gene

cytochrome P450, family 2, subfamily C, polypeptide 8

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CYP2C8 Gene

cytochrome P450, family 2, subfamily C, polypeptide 8

Aliasesfor CYP2C8 gene

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