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CYP2C8 Gene

protein-coding   GIFtS: 69
GCID: GC10M096786

Cytochrome P450, Family 2, Subfamily C, Polypeptide 8

(Previous names: cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase),...)
  See CYP2C8-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cytochrome P450, Family 2, Subfamily C, Polypeptide 81 2     EC 1.14.14.13 8
Cytochrome P450, Subfamily IIC (Mephenytoin 4-Hydroxylase), Polypeptide 81 2     CPC82
Cytochrome P450 Form 12 3     MP-12/MP-202
Cytochrome P450 IIC22 3     Cytochrome P450 2C82
Cytochrome P450 MP-122 3     Flavoprotein-Linked Monooxygenase2
Cytochrome P450 MP-202 3     Microsomal Monooxygenase2
S-Mephenytoin 4-Hydroxylase2 3     P450 Form 12
CYPIIC82 3     Xenobiotic Monooxygenase2

External Ids:    HGNC: 26221   Entrez Gene: 15582   Ensembl: ENSG000001381157   OMIM: 6011295   UniProtKB: P106323   

Export aliases for CYP2C8 gene to outside databases

Previous GC identifers: GC10M095689 GC10M096030 GC10M096927 GC10M096461 GC10M090423


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CYP2C8 Gene:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are
monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids
and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by
phenobarbital. The enzyme is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin,
benzo(a)pyrene, 7-ethyoxycoumarin, and the anti-cancer drug taxol. This gene is located within a cluster of
cytochrome P450 genes on chromosome 10q24. Several transcript variants encoding a few different isoforms have
been found for this gene. (provided by RefSeq, Nov 2010)

GeneCards Summary for CYP2C8 Gene:
CYP2C8 (cytochrome P450, family 2, subfamily C, polypeptide 8) is a protein-coding gene. Diseases associated with CYP2C8 include rhabdomyolysis, cerivastatin-induced, and osteonecrosis of the jaw. GO annotations related to this gene include electron carrier activity and heme binding. An important paralog of this gene is CYP2W1.

UniProtKB/Swiss-Prot: CP2C8_HUMAN, P10632
Function: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is
involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated
compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it generates
only 14,15- and 11,12-cis-epoxyeicosatrienoic acids. It is the principal enzyme responsible for the metabolism
the anti-cancer drug paclitaxel (taxol)

Gene Wiki entry for CYP2C8 Gene

PharmGKB "VIP" summary for CYP2C8


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the CYP2C8 gene promoter:
         GR   p300   GR-beta   HNF-4alpha1   HNF-1A   AREB6   HNF-1   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CYP2C8 promoter sequence
   Search Chromatin IP Primers for CYP2C8

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CYP2C8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q23.33   Ensembl cytogenetic band:  10q23.33   HGNC cytogenetic band: 10q24.1

CYP2C8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CYP2C8 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M096786:  view genomic region     (about GC identifiers)

Start:
96,796,529 bp from pter      End:
96,829,254 bp from pter
Size:
32,726 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CP2C8_HUMAN, P10632 (See protein sequence)
Recommended Name: Cytochrome P450 2C8  
Size: 490 amino acids; 55825 Da
Cofactor: Heme group
Caution: Alternative splicing has been shown to occur but the shorter forms are believed to be non-functional
5 PDB 3D structures from and Proteopedia for CYP2C8:
1PQ2 (3D)        2NNH (3D)        2NNI (3D)        2NNJ (3D)        2VN0 (3D)    
Secondary accessions: A8K9N8 B0AZN2 B7Z1F6 Q5VX93 Q8WWB1 Q9UCZ9
Alternative splicing: 2 isoforms:  P10632-1   P10632-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CYP2C8: NX_P10632

Explore proteomics data for CYP2C8 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for CYP2C8 (P10632) (see all 32)
     PFSAGKR  PGPTPLP  VIGRHRS  LTSVLHD 


    See CYP2C8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_000761.3  NP_001185782.1  NP_001185783.1  NP_001185784.1  

    ENSEMBL proteins: 
     ENSP00000433191   ENSP00000360317   ENSP00000433314   ENSP00000433842   ENSP00000445062  
     ENSP00000442343  
    Reactome Protein details: P10632

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CYP: Cytochrome P450s

    IUPHAR Guide to PHARMACOLOGY protein family classification: CYP2C8
    CYP2 family

    3 InterPro protein domains:
     IPR001128 Cyt_P450
     IPR017972 Cyt_P450_CS
     IPR002401 Cyt_P450_E_grp-I

    Graphical View of Domain Structure for InterPro Entry P10632

    ProtoNet protein and cluster: P10632

    1 Blocks protein domain: IPB002401 E-class P450 group I signature

    UniProtKB/Swiss-Prot: CP2C8_HUMAN, P10632
    Similarity: Belongs to the cytochrome P450 family


    Find genes that share domains with CYP2C8           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CP2C8_HUMAN, P10632
    Function: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is
    involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated
    compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it generates
    only 14,15- and 11,12-cis-epoxyeicosatrienoic acids. It is the principal enzyme responsible for the metabolism
    the anti-cancer drug paclitaxel (taxol)
    Catalytic activity: RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O
    Induction: By phenobarbital

         Genatlas biochemistry entry for CYP2C8:
    cytochrome P450,subfamily IIC (mephenytoin 4-hydroxylase),polypeptide 8

         Enzyme Number (IUBMB): EC 1.14.14.11 2

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004497monooxygenase activity IDA19651758
    GO:0005506iron ion binding IEA--
    GO:0016705oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen ----
    GO:0020037heme binding IEA--
    GO:0034875caffeine oxidase activity IDA18619574
         
    Find genes that share ontologies with CYP2C8           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for CYP2C8

    miRNA
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    hsa-mir-107 (MIRT006956), hsa-mir-103a-3p (MIRT006955)

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    1 qRT-PCR Assays for microRNA that regulate CYP2C8:
    hsa-miR-3919
    SwitchGear 3'UTR luciferase reporter plasmidCYP2C8 3' UTR sequence
    Inhib. RNA
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    Browse Sino Biological Human cDNA Clones
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CP2C8_HUMAN, P10632: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral
    membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    golgi apparatus2
    nucleus2
    cytosol1
    extracellular1
    lysosome1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum ----
    GO:0005789endoplasmic reticulum membrane TAS--

    Find genes that share ontologies with CYP2C8           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CYP2C8 About   (see all 17)  
    See pathways by source

    SuperPathContained pathways About
    1Arachidonic acid metabolism
    Linoleic acid metabolism0.64
    Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)0.00
    Arachidonic acid metabolism0.41
    Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)0.00
    Arachidonic acid metabolism0.40
    Amodiaquine Pathway, Pharmacokinetics0.00
    HETE and HPETE biosynthesis and metabolism0.33
    2Biological oxidations
    Biological oxidations0.56
    Tamoxifen metabolism0.00
    metapathway biotransformation0.42
    Estradiol metabolism0.00
    Sorafenib Pharmacokinetics0.00
    Phenytoin Pathway, Pharmacokinetics0.00
    3Cytochrome P450 - arranged by substrate type
    Cytochrome P450 - arranged by substrate type0.75
    Cyclophosphamide Pathway, Pharmacokinetics0.00
    Phase 1 - Functionalization of compounds0.75
    Ifosfamide Pathway, Pharmacokinetics0.00
    cytochrome P4500.74
    CYP2E1 reactions0.00
    Xenobiotics0.00
    4Chemical carcinogenesis
    Chemical carcinogenesis0.71
    Retinol metabolism0.35
    Drug metabolism - cytochrome P4500.69
    Benzo a pyrene metabolism0.00
    5Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    Metabolic pathways0.38


    Find genes that share SuperPaths with CYP2C8           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    Selected GeneGo (Thomson Reuters) Pathways for CYP2C8 (see all 7)
        Estrogen biosynthesis
    Estradiol metabolism
    Retinol metabolism
    HETE and HPETE biosynthesis and metabolism
    Naphthalene metabolism

    4 BioSystems Pathways for CYP2C8
        cytochrome P450
    Arachidonate Epoxygenase / Epoxide Hydrolase
    Tamoxifen metabolism
    metapathway biotransformation

    4 Reactome Pathways for CYP2C8
        Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)
    Xenobiotics
    Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)
    CYP2E1 reactions

    Selected PharmGKB Pathways for CYP2C8 (see all 17)
        Amodiaquine Pathway, Pharmacokinetics
    Anti-diabetic Drug Repaglinide Pathway, Pharmacokinetics
    Atorvastatin/Lovastatin/Simvastatin Pathway, Pharmacokinetics
    Caffeine Pathway, Pharmacokinetics
    Carbamazepine Pathway, Pharmacokinetics

    Selected Kegg Pathways  (Kegg details for CYP2C8) (see all 7):
        Arachidonic acid metabolism
    Linoleic acid metabolism
    Retinol metabolism
    Drug metabolism - cytochrome P450
    Metabolic pathways

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CYP2C8: 
              Cancer Drug Resistance in human mouse rat
              Drug Metabolism: Phase I Enzymes in human mouse rat
              Drug Metabolism in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CYP2C8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CYP2C8 (P106323 ENSP000003603174) via UniProtKB, MINT, STRING, and/or I2D (see all 104)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    A2MP010233I2D: score=1 
    APOEP026493I2D: score=1 
    BLMHQ138673I2D: score=1 
    DNAJB1P256853I2D: score=1 
    GABARAPL1Q9H0R83I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006082organic acid metabolic process IDA19651758
    GO:0006805xenobiotic metabolic process TAS--
    GO:0017144drug metabolic process IDA19651758
    GO:0019369arachidonic acid metabolic process TAS--
    GO:0019373epoxygenase P450 pathway TAS--

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    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CYP2C8 (CP2C8)

    Selected HMDB Compounds for CYP2C8 (see all 53)    About this table
    CompoundSynonyms CAS #PubMed Ids
    10-HETE10-hydroxyeicosa-all-cis-5,8,11,14-tetraenoate (see all 2)167697-52-1--
    11,12,15-THETA11,12,15-Trihydroxyicosatrienoic acid (see all 5)----
    11,12-Epoxyeicosatrienoic acid10-(3-(2-octenyl)oxiranyl)-5,8-Decadienoic acid (see all 15)81276-02-0--
    11,14,15-THETA(5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoic acid (see all 8)----
    11H-14,15-EETA14,15-Ep-11-HETrE (see all 11)219535-29-2--
    11beta-Hydroxytestosterone11beta,17beta-dihydroxyandrost-4-en-3-one 1816-85-9--
    12,13-EpOMEVernolic acid (see all 12)----
    13-HETE13-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoate (see all 2)151910-72-4--
    14,15-Epoxy-5,8,11-eicosatrienoic acid(5Z,8Z,11Z)-14,15-Epoxyicosa-5.8.11-trienoic acid (see all 11)81276-03-1--
    15(S)-HPETE(5Z,8Z,11Z,13E)-(15S)-15-Hydroperoxyicosa-5,8,11,13-tetraenoate (see all 8)70981-96-3--

    Selected DrugBank Compounds for CYP2C8 (see all 178)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Fluvastatin-- 93957-54-1enzymesubstrate inhibitor11368292 19663817 19934256 10064574 19515014
    PioglitazonePioglitazona [INN-Spanish] (see all 5)111025-46-8enzymesubstrate inhibitor16867170 12642470 19614891 19934256 19515014
    CerivastatinCerivastatin sodium (see all 2)145599-86-6enzymesubstrate inhibitor17178259 12433802 19934256 19515014
    SimvastatinSimvastatin [Usan:Ban:Inn] (see all 4)79902-63-9enzymesubstrate inhibitor17178259 15601807 15998357 19934256
    AmiodaroneAmiodarona [INN-Spanish] (see all 5)1951-25-3enzymesubstrate11038157 19934256 19515014
    AmodiaquineAmodiaquin (see all 4)86-42-0enzymesubstrate11805197 15155557 19934256
    FelodipineDl-Felodipine (see all 4)72509-76-3enzymeinhibitor18413310 15601807 19934256
    Lovastatin6 alpha-Methylcompactin (see all 4)75330-75-5enzymeinhibitor15601807 15998357 19934256
    Montelukast-- 158966-92-8enzymeinhibitor18413310 15601807 19934256
    RepaglinideAG-EE 388 ZW (see all 4)135062-02-1enzymesubstrate19934256 12919179 19515014

    Selected Novoseek inferred chemical compound relationships for CYP2C8 gene (see all 45)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    androstane 82.4 3 15933212 (2), 20214592 (1)
    sulfaphenazole 80.5 2 15581350 (1)
    cerivastatin 74.6 12 12433802 (2), 15716363 (2), 20214592 (2), 15601807 (1) (see all 6)
    paclitaxel 73.7 50 16753005 (5), 15655291 (5), 15716363 (4), 16299241 (4) (see all 20)
    amodiaquine 72.2 6 15155557 (1), 20126327 (1), 18255358 (1), 20214592 (1)
    tolbutamide 71 4 9522439 (1), 15155557 (1), 9578596 (1), 9660842 (1)
    repaglinide 71 5 14534525 (2), 15601807 (1), 19761371 (1), 17923851 (1)
    ketoconazole 68.5 1 18653741 (1)
    phenacetin 68.3 3 15155557 (1), 9929510 (1), 17954527 (1)
    chlorzoxazone 63.8 1 15155557 (1)

    Selected PharmGKB related drug/compound annotations for CYP2C8 gene (see all 28)    About this table
    Drug/compound PharmGKB Annotation
    BisphosphonatesCA  
    amodiaquineCA  
    anastrozole
    clobazam
    crizotinib
    dabrafenib
    dasatinib
    dexlansoprazole
    dextromethorphan
    eltrombopag



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    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CYP2C8 gene (5 alternative transcripts): 
    NM_000770.3  NM_001198853.1  NM_001198854.1  NM_001198855.1  NM_030878.1  

    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000527420 ENST00000371270(uc001kkb.3) ENST00000490994(uc010qoa.2 uc010qoc.2)
    ENST00000526814(uc010qob.2) ENST00000527953(uc001kkc.3 uc010qod.1)
    ENST00000533320 ENST00000525991 ENST00000531714 ENST00000479946 ENST00000535898
    ENST00000539050
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    Selected AceView cDNA sequences (see all 124):

    CB155995 BX118253 CB157029 CD013969 AV681651 AV645956 BU735810 BE773755 
    CD014119 CB164329 CD013967 CB154182 CB115644 AV661290 CD013968 BP343375 
    CB154352 CB154252 CB164724 AV653304 AV649270 AA709270 AV719071 BX646320 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CYP2C8 (see all 10)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b
    SP1:                          -     -                                                                 -                     
    SP2:                                                                                            -     -                     
    SP3:                          -     -                                                           -     -                     
    SP4:                          -     -                                                                 -                     
    SP5:                          -     -                                                           -     -                     


    ECgene alternative splicing isoforms for CYP2C8

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CYP2C8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGCTATTTT
    CYP2C8 Expression
    About this image


    CYP2C8 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Liver (Hepatobiliary System)    fully expand to see all 4 entries
             Mature Hepatocytes Liver Lobule
             Hepatocytes
    CYP2C8 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CYP2C8 Protein Expression
        Pathway & Disease-focused RT2 Profiler PCR Arrays including CYP2C8: 
              Cancer Drug Resistance in human mouse rat
              Drug Metabolism: Phase I Enzymes in human mouse rat
              Drug Metabolism in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of chordates.

    Orthologs for CYP2C8 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cyp2c295
    Cyp2c391
    cytochrome P450, family 2, subfamily c, polypeptide more1, 5 77.44(n)1
    71.98(a)1
      19 (33.91 cM)5
    130981  NM_010003.21  NP_034133.21 
     392694055 
    African clawed frog
    (Xenopus laevis)
    Amphibia BC045126.12   -- 73.72(n)    BC045126.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC044463.12   -- 72.49(n)   393108  BC044463.1 


    ENSEMBL Gene Tree for CYP2C8 (if available)
    TreeFam Gene Tree for CYP2C8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CYP2C8 gene
    CYP2W12  CYP2A62  CYP2F12  CYP2A72  CYP2B62  CYP2C192  CYP2R12  CYP2J22  
    CYP2U12  CYP2S12  CYP2E12  CYP2C92  CYP2D62  CYP2C182  CYP2A132  
    Selected SIMAP similar genes for CYP2C8 using alignment to 5 protein entries:     CP2C8_HUMAN (see all proteins) (see all similar genes):
    CYP 2C    CYP2C19    CYP2C18    CYP2C9    CYP2C    CYP2E1
    CYP2A6    CYP2G1P    CYP2A13    CYP2A6V2    CYP2A7    CYP2B
    CYP2B7    CYP2F1    DKFZp686I24235    CYP2S1    CYP2B6    CYP2R1

    Find genes that share paralogs with CYP2C8           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for CYP2C8
    PGOHUM00000241006


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    CP2C8_HUMAN, P10632: CYP2C8 genetic variations may be associated with adverse effects of cerivastatin including acute
    rhabdomyolysis [MIM:601129]


    Selected SNPs for CYP2C8 (see all 822)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs671322221,2
    C--96801568(-) ACAGA-/TTTTT 
            
    TTTTT
    4 -- int11Minor allele frequency- TTTTT:0.00NA 2
    rs1130636261,2
    C--96801802(+) TATTT-/TAAAAA 4 -- int11Minor allele frequency- T:0.00CSA 2
    rs355256031,2
    C--96802161(+) GAAAT-/AAAAAA 4 -- int11Minor allele frequency- A:0.00NA 2
    rs770995941,2
    C--96802169(+) AAAAAA/TTTAAA 4 -- int10--------
    rs584196211,2
    C--96803621(+) ACACA-/CATATAC 4 -- int10--------
    rs115721511,2
    C--96806523(-) TTCTTT/CTTTTT 4 -- int1 trp31Minor allele frequency- C:0.01NS 176
    rs115721391,2
    C,F,H--96808886(-) ttattC/Tggatt 4 -- int118Minor allele frequency- T:0.24NS EA WA NA CSA 2152
    rs361106181,2
    C--96810632(+) AAAAA-/ACCCCA 4 -- int11Minor allele frequency- A:0.50NA 2
    rs768422961,2
    C--96810641(+) AAAAAA/CCCCAG 4 -- int10--------
    rs728186931,2
    C--96810731(+) AAAACA/GTGACC 4 -- int10--------

    HapMap Linkage Disequilibrium report for CYP2C8 (96796529 - 96829254 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CYP2C8:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv467436CNV Loss19166990

    The Human Cytochrome P450 Allele Nomenclature Database: CYP2C8 
    Human Gene Mutation Database (HGMD): CYP2C8
    Locus Specific Mutation Databases (LSDB): CYP2C8

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CYP2C8
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601129    OMIM disorders: --

    3 diseases for CYP2C8:    
    About MalaCards
    rhabdomyolysis, cerivastatin-induced    osteonecrosis of the jaw    osteonecrosis

    2 diseases from the University of Copenhagen DISEASES database for CYP2C8:
    Malaria     Osteonecrosis

    Find genes that share disorders with CYP2C8           About GenesLikeMe

    2 Novoseek inferred disease relationships for CYP2C8 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0.922 3 14759713 (2)
    cancer 0 1 17558302 (1)

    Genetic Association Database (GAD): CYP2C8
    Human Genome Epidemiology (HuGE) Navigator: CYP2C8 (106 documents)

    Export disorders for CYP2C8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CYP2C8 gene, integrated from 10 sources (see all 318):
    (articles sorted by number of sources associating them with CYP2C8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Determinants of cytochrome P450 2C8 substrate binding: structures of complexes with montelukast, troglitazone, felodipine, and 9-cis- retinoic acid. (PubMed id 18413310)1, 2, 7, 9 Schoch G.A....Johnson E.F. (J. Biol. Chem. 2008)
    2. Structure of human microsomal cytochrome P450 2C8. Evidence for a peripheral fatty acid binding site. (PubMed id 14676196)1, 2, 7, 9 Schoch G.A....Johnson E.F. (J. Biol. Chem. 2004)
    3. Polymorphisms in human CYP2C8 decrease metabolism of the anticancer drug paclitaxel and arachidonic acid. (PubMed id 11668219)1, 2, 4 Dai D.... Goldstein J.A. (Pharmacogenetics 2001)
    4. Role of cytochrome P450 2C8 and 2J2 genotypes in calcineurin inhibitor-induced chronic kidney disease. (PubMed id 18769365)1, 4, 9 Smith H.E....Totah R.A. (Pharmacogenet. Genomics 2008)
    5. CYP2C8 haplotype structures and their influence on pharmacokinetics of paclitaxel in a Japanese population. (PubMed id 17558302)1, 4, 9 Saito Y....Sawada J. (Pharmacogenet. Genomics 2007)
    6. Influence of SLCO1B1 and CYP2C8 gene polymorphisms on rosiglitazone pharmacokinetics in healthy volunteers. (PubMed id 19129086)1, 4, 9 Aquilante C.L....Kosmiski L.A. (Hum. Genomics 2008)
    7. CYP2C8 polymorphism among the Portuguese. (PubMed id 16475901)1, 4, 9 Cavaco I....Ribeiro V. (Clin. Chem. Lab. Med. 2006)
    8. Association of CYP2C8, CYP3A4, CYP3A5, and ABCB1 polymorphisms with the pharmacokinetics of paclitaxel. (PubMed id 16299241)1, 4, 9 Henningsson A....McLeod H.L. (Clin. Cancer Res. 2005)
    9. The effect of the cytochrome P450 CYP2C8 polymorphism on the disposition of (R)-ibuprofen enantiomer in healthy subjects. (PubMed id 15606441)1, 4, 9 MartA-nez C....AgA_ndez J.A. (Br J Clin Pharmacol 2005)
    10. Interindividual variability in ibuprofen pharmacokinetics is related to interaction of cytochrome P450 2C8 and 2C9 amino acid polymorphisms. (PubMed id 15289789)1, 4, 9 GarcA-a-MartA-n E....AgA_ndez J.A. (Clin. Pharmacol. Ther. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1558 HGNC: 2622 AceView: CYP2C8 Ensembl:ENSG00000138115 euGenes: HUgn1558
    ECgene: CYP2C8 Kegg: 1558 H-InvDB: CYP2C8

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CYP2C8 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CYP2C8 Genetics and Cytogenetics in Oncology and Haematology
    Cytochrome P450 Allele Nomenclature Committeehttp://www.cypalleles.ki.se/cyp2c8.htm
    NIEHS-SNPshttp://egp.gs.washington.edu/data/cyp2c8/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CYP2C8 gene:
    Search GeneIP for patents involving CYP2C8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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