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Aliases for CYP2C8 Gene

Aliases for CYP2C8 Gene

  • Cytochrome P450 Family 2 Subfamily C Member 8 2 3 5
  • Cytochrome P450, Subfamily IIC (Mephenytoin 4-Hydroxylase), Polypeptide 8 2 3
  • Cytochrome P450, Family 2, Subfamily C, Polypeptide 8 2 3
  • S-Mephenytoin 4-Hydroxylase 3 4
  • Cytochrome P450 Form 1 3 4
  • Cytochrome P450 MP-12 3 4
  • Cytochrome P450 MP-20 3 4
  • Cytochrome P450 IIC2 3 4
  • EC 1.14.14.1 4 61
  • CYPIIC8 3 4
  • Flavoprotein-Linked Monooxygenase 3
  • Microsomal Monooxygenase 3
  • Xenobiotic Monooxygenase 3
  • Cytochrome P450 2C8 3
  • P450 Form 1 3
  • MP-12/MP-20 3
  • CPC8 3

External Ids for CYP2C8 Gene

Previous GeneCards Identifiers for CYP2C8 Gene

  • GC10M095689
  • GC10M096030
  • GC10M096927
  • GC10M096461
  • GC10M096786
  • GC10M090423

Summaries for CYP2C8 Gene

Entrez Gene Summary for CYP2C8 Gene

  • This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, benzo(a)pyrene, 7-ethyoxycoumarin, and the anti-cancer drug taxol. This gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]

GeneCards Summary for CYP2C8 Gene

CYP2C8 (Cytochrome P450 Family 2 Subfamily C Member 8) is a Protein Coding gene. Diseases associated with CYP2C8 include Cyp2c8-Related Altered Drug Metabolism and Osteonecrosis Of The Jaw. Among its related pathways are Cytochrome P450 - arranged by substrate type and Arachidonate Epoxygenase / Epoxide Hydrolase. GO annotations related to this gene include iron ion binding and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen. An important paralog of this gene is CYP2C19.

UniProtKB/Swiss-Prot for CYP2C8 Gene

  • Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it generates only 14,15- and 11,12-cis-epoxyeicosatrienoic acids. It is the principal enzyme responsible for the metabolism the anti-cancer drug paclitaxel (taxol).

Gene Wiki entry for CYP2C8 Gene

PharmGKB "VIP" Summary for CYP2C8 Gene

No data available for CIViC summary , Tocris Summary , fRNAdb sequence ontologies and piRNA Summary for CYP2C8 Gene

Genomics for CYP2C8 Gene

Regulatory Elements for CYP2C8 Gene

Enhancers for CYP2C8 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10G095259 2 FANTOM5 Ensembl ENCODE dbSUPER 11.4 -195.0 -195037 10.2 HDGF FOXA2 PKNOX1 MLX ARNT ZFP64 FEZF1 ZNF766 FOS ZNF263 PDLIM1 CYP2C8 NOC3L ACSM6 GC10M095264 GC10M095235
GH10G095234 1.4 Ensembl ENCODE dbSUPER 10.8 -166.5 -166491 2.2 PKNOX1 TBL1XR1 BMI1 RAD21 CBX5 RELB ETV6 FOS IKZF2 CREM ACSM6 PDLIM1 CYP2C8 TCTN3 GC10M095235 ENSG00000234026
GH10G095227 1.1 ENCODE dbSUPER 10.7 -160.7 -160711 5.4 HDAC1 PKNOX1 NFIB SIN3A RFX5 YY1 ETS1 GATA2 RCOR1 FOS ACSM6 PDLIM1 CYP2C8 TCTN3 ENSG00000234026
GH10G095182 1.4 FANTOM5 ENCODE 8.2 -114.1 -114086 1.5 ATF1 CREB3L1 SIN3A ZNF2 YY1 ETS1 ZNF121 GLIS2 ELK1 ZNF143 PDLIM1 CYP2C8 ACSM6 TCTN3 SORBS1 PAWRP1 ENSG00000274691
GH10G095244 1.4 Ensembl ENCODE dbSUPER 7.6 -177.6 -177638 4.5 CBX3 TBL1XR1 NFIB RAD21 ZNF121 GLIS2 ZNF366 ZNF143 FOS ETV6 CYP2C8 TCTN3 GC10M095235 GC10M095264
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CYP2C8 on UCSC Golden Path with GeneCards custom track

Genomic Location for CYP2C8 Gene

Chromosome:
10
Start:
95,036,772 bp from pter
End:
95,069,498 bp from pter
Size:
32,727 bases
Orientation:
Minus strand

Genomic View for CYP2C8 Gene

Genes around CYP2C8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CYP2C8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CYP2C8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYP2C8 Gene

Proteins for CYP2C8 Gene

  • Protein details for CYP2C8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P10632-CP2C8_HUMAN
    Recommended name:
    Cytochrome P450 2C8
    Protein Accession:
    P10632
    Secondary Accessions:
    • A8K9N8
    • B0AZN2
    • B7Z1F6
    • Q5VX93
    • Q8WWB1
    • Q9UCZ9

    Protein attributes for CYP2C8 Gene

    Size:
    490 amino acids
    Molecular mass:
    55825 Da
    Cofactor:
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CYP2C8 Gene

    Alternative splice isoforms for CYP2C8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CYP2C8 Gene

Selected DME Specific Peptides for CYP2C8 Gene

P10632:
  • CLVEELRK
  • LTSVLHD
  • QVCNNFP
  • KSDYFMPFS
  • FGMGKRS
  • VFTVYFG
  • EEFSGRG
  • EKVKEHQ
  • GMGKRSIE
  • PGPTPLP
  • PFSAGKR
  • LLLLLKHP
  • IEDRVQEEA
  • NPRDFID
  • QIDVKDI
  • GYEAVKEAL
  • GEGLARME
  • CDPTFIL
  • YGPVFTVY
  • SLPPSYQ
  • VIGRHRS
  • VVLVLCLS
  • FDPGHFL
  • TTILQNF
  • TTSTTLRY
  • FLFLTTILQ
  • LARMELFLFLT
  • AGTETTS
  • GNFKKSD
  • TAKVQEEI
  • KFRNYLIPKGT
  • PCNVICS

Post-translational modifications for CYP2C8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for CYP2C8 Gene

Gene Families for CYP2C8 Gene

Protein Domains for CYP2C8 Gene

Suggested Antigen Peptide Sequences for CYP2C8 Gene

Graphical View of Domain Structure for InterPro Entry

P10632

UniProtKB/Swiss-Prot:

CP2C8_HUMAN :
  • Belongs to the cytochrome P450 family.
Family:
  • Belongs to the cytochrome P450 family.
genes like me logo Genes that share domains with CYP2C8: view

Function for CYP2C8 Gene

Molecular function for CYP2C8 Gene

GENATLAS Biochemistry:
cytochrome P450,subfamily IIC (mephenytoin 4-hydroxylase),polypeptide 8
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=7.18 uM for paclitaxel {ECO:0000269 PubMed:26427316}; KM=1.35 uM for amodiaquine {ECO:0000269 PubMed:26427316}; Vmax=2.18 pmol/min/pmol enzyme with paclitaxel as substrate {ECO:0000269 PubMed:26427316}; Vmax=11.30 pmol/min/pmol enzyme with amodiaquine as substrate {ECO:0000269 PubMed:26427316};
UniProtKB/Swiss-Prot CatalyticActivity:
RH + [reduced NADPH--hemoprotein reductase] + O(2) = ROH + [oxidized NADPH--hemoprotein reductase] + H(2)O.
UniProtKB/Swiss-Prot Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it generates only 14,15- and 11,12-cis-epoxyeicosatrienoic acids. It is the principal enzyme responsible for the metabolism the anti-cancer drug paclitaxel (taxol).
UniProtKB/Swiss-Prot Induction:
By phenobarbital.

Enzyme Numbers (IUBMB) for CYP2C8 Gene

Gene Ontology (GO) - Molecular Function for CYP2C8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004497 monooxygenase activity TAS,IEA --
GO:0005506 iron ion binding IEA --
GO:0008392 arachidonic acid epoxygenase activity IBA --
GO:0016491 oxidoreductase activity IEA --
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA --
genes like me logo Genes that share ontologies with CYP2C8: view
genes like me logo Genes that share phenotypes with CYP2C8: view

Animal Model Products

CRISPR Products

miRNA for CYP2C8 Gene

miRTarBase miRNAs that target CYP2C8

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CYP2C8 Gene

Localization for CYP2C8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYP2C8 Gene

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CYP2C8 gene
Compartment Confidence
endoplasmic reticulum 5
peroxisome 2
nucleus 2
golgi apparatus 2
extracellular 1
cytoskeleton 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for CYP2C8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane IEA --
GO:0031090 organelle membrane IEA --
GO:0043231 intracellular membrane-bounded organelle IEA --
genes like me logo Genes that share ontologies with CYP2C8: view

Pathways & Interactions for CYP2C8 Gene

genes like me logo Genes that share pathways with CYP2C8: view

Gene Ontology (GO) - Biological Process for CYP2C8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002933 lipid hydroxylation IDA 14559847
GO:0006082 organic acid metabolic process IDA 19651758
GO:0006805 xenobiotic metabolic process TAS --
GO:0008202 steroid metabolic process IDA 14559847
GO:0017144 drug metabolic process IDA 19651758
genes like me logo Genes that share ontologies with CYP2C8: view

No data available for SIGNOR curated interactions for CYP2C8 Gene

Drugs & Compounds for CYP2C8 Gene

(276) Drugs for CYP2C8 Gene - From: DrugBank, PharmGKB, ClinicalTrials, ApexBio, FDA Approved Drugs, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Paclitaxel Approved, Vet_approved Pharma Enzyme, substrate Tubulin and Bcl2 inhibitor, Taxanes 2864
Rosiglitazone Approved, Investigational Pharma Full agonist, Agonist, Enzyme, substrate, inhibitor Potent PPARγ agonist, Potent and selective PPARgamma agonist; antidiabetic agent. 220
Amodiaquine Approved Pharma Enzyme, substrate 99
Repaglinide Approved, Investigational Pharma Enzyme, substrate Kir6 (KATP) channel blocker 51
Lapatinib Approved March 2007, Investigational Pharma Enzyme, substrate, inhibitor EGFR/HER2 inhibitor,potent,selective and reversible, HER2 and EGFR kinase inhibitor, HER2 Inhibitors, Kinase Inhibitors, Epidermal growth factor receptor (EGFR) inhibitors 301

(52) Additional Compounds for CYP2C8 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
nadph
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-D-ribofuranosyl-3-pyridinecarboxamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosyl-3-pyridinecarboxamide
  • b-NADPH
53-57-6
11,12,15-THETA
  • 11,12,15-TriHETRE
  • 11,12,15-Trihydroxyicosatrienoate
  • 11,12,15-Trihydroxyicosatrienoic acid
  • 11,12,15S-Trihydroxy-5Z,8Z,13E-eicosatrienoate
  • 11,12,15S-Trihydroxy-5Z,8Z,13E-eicosatrienoic acid
11,12-Epoxyeicosatrienoic acid
  • (5Z,8Z,14Z)-11,12-Epoxyeicosa-5,8,14-trienoate
  • (5Z,8Z,14Z)-11,12-Epoxyeicosa-5,8,14-trienoic acid
  • (5Z,8Z,14Z)-11,12-Epoxyicosa-5,8,14-trienoate
  • (5Z,8Z,14Z)-11,12-Epoxyicosa-5,8,14-trienoic acid
  • 10-(3-(2-Octenyl)oxiranyl)-5,8-Decadienoate
81276-02-0
11,14,15-THETA
  • (5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoate
  • (5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoic acid
  • (5Z,8Z,12E)-11,14,15-Trihydroxyicosa-5,8,12-trienoate
  • (5Z,8Z,12E)-11,14,15-Trihydroxyicosa-5,8,12-trienoic acid
  • 11,14,15-Trihydroxy-5Z,8Z,12E-eicosatrienoate
11H-14,15-EETA
  • (5Z,8Z,12E)-14,15-Epoxy-11-hydroxyeicosa-5,8,12-trienoate
  • (5Z,8Z,12E)-14,15-Epoxy-11-hydroxyeicosa-5,8,12-trienoic acid
  • (5Z,8Z,12E)-14,15-Epoxy-11-hydroxyicosa-5,8,12-trienoate
  • (5Z,8Z,12E)-14,15-Epoxy-11-hydroxyicosa-5,8,12-trienoic acid
  • 11-Hydroxy-14,15-EETA
219535-29-2

(1) ApexBio Compounds for CYP2C8 Gene

Compound Action Cas Number
Amiodarone HCl Anti-arrhythmic drug 19774-82-4
genes like me logo Genes that share compounds with CYP2C8: view

Transcripts for CYP2C8 Gene

Unigene Clusters for CYP2C8 Gene

Cytochrome P450, family 2, subfamily C, polypeptide 8:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CYP2C8 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b
SP1: - - -
SP2: - -
SP3: - - - -
SP4: - - -
SP5: - - - -
SP6: - - -
SP7: -
SP8: - -
SP9: - -
SP10:

Relevant External Links for CYP2C8 Gene

GeneLoc Exon Structure for
CYP2C8
ECgene alternative splicing isoforms for
CYP2C8

Expression for CYP2C8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CYP2C8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CYP2C8 Gene

This gene is overexpressed in Liver (x49.4).

Protein differential expression in normal tissues from HIPED for CYP2C8 Gene

This gene is overexpressed in Gallbladder (48.7) and Liver (16.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CYP2C8 Gene



Protein tissue co-expression partners for CYP2C8 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CYP2C8 Gene:

CYP2C8

SOURCE GeneReport for Unigene cluster for CYP2C8 Gene:

Hs.709188

Evidence on tissue expression from TISSUES for CYP2C8 Gene

  • Liver(5)
  • Blood(4.4)
  • Kidney(4.3)
genes like me logo Genes that share expression patterns with CYP2C8: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CYP2C8 Gene

Orthologs for CYP2C8 Gene

This gene was present in the common ancestor of animals.

Orthologs for CYP2C8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CYP2C8 34 35
  • 98.91 (n)
mouse
(Mus musculus)
Mammalia Cyp2c39 34 16 35
  • 77.44 (n)
Cyp2c65 35
  • 73 (a)
ManyToMany
Cyp2c38 35
  • 72 (a)
ManyToMany
Cyp2c66 35
  • 72 (a)
ManyToMany
Cyp2c29 35
  • 71 (a)
ManyToMany
Cyp2c50 35
  • 69 (a)
ManyToMany
Cyp2c37 35
  • 68 (a)
ManyToMany
Cyp2c54 35
  • 68 (a)
ManyToMany
Cyp2c68 35
  • 66 (a)
ManyToMany
Cyp2c69 35
  • 66 (a)
ManyToMany
Cyp2c67 35
  • 65 (a)
ManyToMany
Cyp2c40 35
  • 62 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia CYP2C18 35
  • 77 (a)
ManyToMany
-- 35
  • 75 (a)
ManyToMany
-- 35
  • 75 (a)
ManyToMany
CYP2C87 35
  • 75 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Cyp2c7 34
  • 76.62 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 67 (a)
ManyToMany
-- 35
  • 66 (a)
ManyToMany
-- 35
  • 65 (a)
ManyToMany
-- 35
  • 65 (a)
ManyToMany
-- 35
  • 63 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia CYP2C21 35
  • 66 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.15643 34
zebrafish
(Danio rerio)
Actinopterygii -- 34
fruit fly
(Drosophila melanogaster)
Insecta Cyp18a1 36
  • 33 (a)
Cyp303a1 36
  • 27 (a)
Cyp304a1 36
  • 27 (a)
Cyp307a1 36
  • 27 (a)
worm
(Caenorhabditis elegans)
Secernentea B0213.11 36
  • 39 (a)
C12D5.7 36
  • 33 (a)
C49C8.4 36
  • 33 (a)
C50H11.15 36
  • 33 (a)
F41B5.4 36
  • 33 (a)
F44C8.1 36
  • 33 (a)
K09A11.2 36
  • 33 (a)
K09A11.4 36
  • 33 (a)
B0213.10 36
  • 32 (a)
C45H4.17 36
  • 32 (a)
C45H4.2 36
  • 32 (a)
F41B5.3 36
  • 32 (a)
K09A11.3 36
  • 32 (a)
Y49C4A.9 36
  • 32 (a)
B0213.16 36
  • 31 (a)
C34B7.3 36
  • 31 (a)
C41G6.1 36
  • 31 (a)
F41B5.2 36
  • 31 (a)
F41B5.7 36
  • 31 (a)
K05D4.4 36
  • 31 (a)
R08F11.3 36
  • 31 (a)
T10H4.11 36
  • 31 (a)
B0304.3 36
  • 30 (a)
C03G6.15 36
  • 30 (a)
C49G7.8 36
  • 30 (a)
F14H3.10 36
  • 30 (a)
K07C6.2 36
  • 30 (a)
K07C6.3 36
  • 30 (a)
K07C6.5 36
  • 30 (a)
K09D9.2 36
  • 30 (a)
T09H2.1 36
  • 30 (a)
T10H4.10 36
  • 29 (a)
Y5H2B.6 36
  • 29 (a)
C25E10.2 36
  • 28 (a)
Species where no ortholog for CYP2C8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CYP2C8 Gene

ENSEMBL:
Gene Tree for CYP2C8 (if available)
TreeFam:
Gene Tree for CYP2C8 (if available)

Paralogs for CYP2C8 Gene

Variants for CYP2C8 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for CYP2C8 Gene

CP2C8_HUMAN-P10632
Several alleles are found in the human population, contributing to interindividual variations in the therapeutic efficacy and toxicity of a myriad of drugs such as paclitaxel or amodiaquine. The allele shown here is CYP2C8*1 (PubMed:26427316). CYP2C8 genetic variations may be associated with adverse effects of cerivastatin including acute rhabdomyolysis [MIM:601129].

Sequence variations from dbSNP and Humsavar for CYP2C8 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs10509681 drug-response 95,038,992(+) ATTCT(C/T)TGTCA nc-transcript-variant, reference, missense
rs1000049949 -- 95,055,013(+) AATAA(C/T)AATAA intron-variant
rs1000101356 -- 95,044,332(+) CTGAT(A/G)TTTTA intron-variant
rs1000159495 -- 95,061,349(+) TCAAC(C/T)TCTTC intron-variant
rs1000199094 -- 95,044,329(+) ATGCT(C/G)ATATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CYP2C8 Gene

Variant ID Type Subtype PubMed ID
esv2761618 CNV gain 21179565
esv3624264 CNV gain 21293372
nsv1035409 CNV loss 25217958
nsv1044182 CNV gain 25217958
nsv1050544 CNV gain 25217958
nsv467436 CNV loss 19166990
nsv551964 CNV loss 21841781

Variation tolerance for CYP2C8 Gene

Residual Variation Intolerance Score: 93.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.17; 75.82% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CYP2C8 Gene

Human Gene Mutation Database (HGMD)
CYP2C8
The Human Cytochrome P450 Allele Nomenclature Database
CYP2C8
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CYP2C8

Disorders for CYP2C8 Gene

MalaCards: The human disease database

(3) MalaCards diseases for CYP2C8 Gene - From: GeneTests, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
cyp2c8-related altered drug metabolism
  • rhabdomyolysis, cerivastatin-induced
osteonecrosis of the jaw
osteonecrosis
  • avascular necrosis of bone
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CYP2C8

Genetic Association Database (GAD)
CYP2C8
Human Genome Epidemiology (HuGE) Navigator
CYP2C8
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CYP2C8
genes like me logo Genes that share disorders with CYP2C8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CYP2C8 Gene

Publications for CYP2C8 Gene

  1. Determinants of cytochrome P450 2C8 substrate binding: structures of complexes with montelukast, troglitazone, felodipine, and 9-cis- retinoic acid. (PMID: 18413310) Schoch G.A. … Johnson E.F. (J. Biol. Chem. 2008) 3 4 22 25 64
  2. Pharmacogenetic studies of Paclitaxel in the treatment of ovarian cancer. (PMID: 19143748) GrAcen H. … Peterson C. (Basic Clin. Pharmacol. Toxicol. 2009) 3 22 46 64
  3. Characterisation of CYP2C8, CYP2C9 and CYP2C19 polymorphisms in a Ghanaian population. (PMID: 19954515) Kudzi W. … Mills J.J. (BMC Med. Genet. 2009) 3 22 46 64
  4. Role of cytochrome P450 2C8 and 2J2 genotypes in calcineurin inhibitor-induced chronic kidney disease. (PMID: 18769365) Smith H.E. … Totah R.A. (Pharmacogenet. Genomics 2008) 3 22 46 64
  5. Influence of SLCO1B1 and CYP2C8 gene polymorphisms on rosiglitazone pharmacokinetics in healthy volunteers. (PMID: 19129086) Aquilante C.L. … Kosmiski L.A. (Hum. Genomics 2008) 3 22 46 64

Products for CYP2C8 Gene

Sources for CYP2C8 Gene

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