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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CYP2C18 Gene

protein-coding   GIFtS: 63
GCID: GC10P096433

cytochrome P450, family 2, subfamily C, polypeptide 18

(Previous names: cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase),...)
(Previous symbol: CYP2C17)
 Explore 11 diseases affiliated with
CYP2C18 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CYP2C18    

Aliases
for CYP2C18 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Cytochrome P450, Family 2, Subfamily C, Polypeptide 181 2     EC 1.14.14.13 8
CPCI1 2     (S)-Mephenytoin Hydroxylase Associated Cytochrome P4502
CYP2C1 2     P450-6B/29C2
CYP2C171 2     Cytochrome P450 2C182
P450IIC171 2     Cytochrome P450, Subfamily IIC (Mephenytoin 4-Hydroxylase), Polypeptide 172
Cytochrome P450, Subfamily IIC (Mephenytoin 4-Hydroxylase), Polypeptide 181 2     Flavoprotein-Linked Monooxygenase2
Cytochrome P450-6b/29c2 3     Microsomal Monooxygenase2
CYPIIC182 3     Unspecific Monooxygenase2

External Ids:    HGNC: 26201   Entrez Gene: 15622   Ensembl: ENSG000001082427   OMIM: 6011315   UniProtKB: P332603   

Export aliases for CYP2C18 gene to outside databases

Previous GC identifers: GC10P095336 GC10M095677 GC10P096576 GC10P096107 GC10P090071


Summaries
for CYP2C18 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CYP2C18:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are
monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and
other lipids. This protein localizes to the endoplasmic reticulum but its specific substrate has not yet been
determined. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. An additional gene,
CYP2C17, was once thought to exist; however, CYP2C17 is now considered an artefact based on a chimera of CYP2C18 and
CYP2C19. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CP2CI_HUMAN, P33260
Function: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in
an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including
steroids, fatty acids, and xenobiotics

Gene Wiki entry for CYP2C18


Genomic Views
for CYP2C18 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.1  NT_030059.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CYP2C18 gene promoter:
         MyoD   NF-kappaB   MZF-1   NF-AT4   FOXC1   NF-AT3   NF-kappaB1   TGIF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CYP2C18 promoter sequence
   Search SABiosciences Chromatin IP Primers for CYP2C18

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CYP2C18


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q24   Ensembl cytogenetic band:  10q23.33   HGNC cytogenetic band: 10q24

CYP2C18 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CYP2C18 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P096433:  view genomic region     (about GC identifiers)

Start:
 96,442,710 bp from pter      End:
 96,495,947 bp from pter
Size:
 53,238 bases      Orientation:
 plus strand

Proteins
for CYP2C18 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CP2CI_HUMAN, P33260 (See protein sequence)
Recommended Name: Cytochrome P450 2C18  
Size: 490 amino acids; 55711 Da
Cofactor: Heme group (By similarity)
Subcellular location: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral
membrane protein
1 PDB 3D structure from and Proteopedia for CYP2C18:
2H6P (3D)    
Secondary accessions: B2R8K2 Q16703 Q16751 Q4VAT5 Q6GRG1
Alternative splicing: 2 isoforms:  P33260-1   P33260-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CYP2C18: NX_P33260

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P33260

    • 4/30 DME Specific Peptides for CYP2C18 (P33260) (see all 30)
     PFSAGKR  QVCNNFP  FDPGHFL  TTILQNF 

    CYP2C18 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_000763.1  NP_001122397.1  

    ENSEMBL proteins: 
     ENSP00000285979   ENSP00000341293  
    Reactome Protein details: P33260
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    Uscn Proteins for CYP2C18

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0005792microsome ----


    CYP2C18 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for CYP2C18 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CYP2C18 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR001128 Cyt_P450
     IPR017972 Cyt_P450_CS
     IPR002401 Cyt_P450_E_grp-I

    Graphical View of Domain Structure for InterPro Entry P33260

    ProtoNet protein and cluster: P33260

    1 Blocks protein family: IPB002401 E-class P450 group I signature

    UniProtKB/Swiss-Prot: CP2CI_HUMAN, P33260
    Similarity: Belongs to the cytochrome P450 family


    Function
    for CYP2C18 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CP2CI_HUMAN, P33260
    Function: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in
    an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including
    steroids, fatty acids, and xenobiotics
    Catalytic activity: RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O
    Induction: P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs,
    pesticides, and carcinogens

         Genatlas biochemistry entry for CYP2C18:
    cytochrome P450,subfamily IIC (mephenytoin 4-hydroxylase),polypeptide 18

    Enzyme Number (IUBMB): EC 1.14.14.11 2

    miRNA
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    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004497monooxygenase activity TAS8110777
    GO:0005506iron ion binding IEA--
    GO:0008390testosterone 16-alpha-hydroxylase activity ----
    GO:0009055electron carrier activity IEA--
    GO:0019825oxygen binding TAS8110777


    CYP2C18 for ontologies           About GeneDecksing



    Pathways & Interactions
    for CYP2C18 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/11 super-pathways (see all 11) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Cytochrome P450 - arranged by substrate type
    		Cytochrome P450 - arranged by substrate type1.00
    		cytochrome P4500.73
    		Phase 1 - Functionalization of compounds0.74
    2Drug metabolism - cytochrome P450
    		Drug metabolism - cytochrome P4501.00
    		Retinol metabolism0.40
    		Metabolism of xenobiotics by cytochrome P4500.73
    3Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)
    		Warfarin Pathway, Pharmacokinetics0.45
    		Benzo[a]pyrene metabolism0.33
    		Benzo[a]pyrene metabolism0.33
    4Retinol metabolism
    		Retinol metabolism1.00
    		Retinol metabolism0.95
    5Metabolism
    		Metabolism1.00
    		Metabolic pathways0.38

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 EMD Millipore Pathways for CYP2C18
        Retinol metabolism
    Benzo[a]pyrene metabolism


    2 GeneGo (Thomson Reuters) Pathways for CYP2C18
        Retinol metabolism
    Benzo[a]pyrene metabolism

    4 BioSystems Pathways for CYP2C18 
        cytochrome P450
    Tryptophan metabolism
    FOXA1 transcription factor network
    metapathway biotransformation

    5        Reactome Pathways for CYP2C18
        Cytochrome P450 - arranged by substrate type
    Xenobiotics
    Metabolism
    Biological oxidations
    Phase 1 - Functionalization of compounds

    1 PharmGKB Pathway for CYP2C18
        Warfarin Pathway, Pharmacokinetics

    5/6         Kegg Pathways  (Kegg details for CYP2C18) (see all 6):
        Arachidonic acid metabolism
    Linoleic acid metabolism
    Retinol metabolism
    Metabolism of xenobiotics by cytochrome P450
    Drug metabolism - cytochrome P450


    CYP2C18 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CYP2C18

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/99 Interacting proteins for CYP2C18 (P332603 ENSP000002859794) via UniProtKB, MINT, STRING, and/or I2D (see all 99)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    A2MP010233I2D: score=1 
    ECSITQ9BQ953I2D: score=1 
    ALDH1A1ENSP000002977854STRING: ENSP00000297785
    CYP1A1ENSP000003690504STRING: ENSP00000369050
    CYP1A2ENSP000003420074STRING: ENSP00000342007
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006805xenobiotic metabolic process TAS--
    GO:0044281small molecule metabolic process TAS--


    CYP2C18 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CYP2C18 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CYP2C18 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for CYP2C18

    10/49 HMDB Compounds for CYP2C18 (see all 49)    About this table
    CompoundSynonyms CAS #PubMed Ids
    10-HETE10-hydroxyeicosa-all-cis-5,8,11,14-tetraenoate (see all 2)167697-52-1--
    11,12,15-THETA11,12,15-Trihydroxyicosatrienoic acid (see all 5)----
    11,12-Epoxyeicosatrienoic acid10-(3-(2-octenyl)oxiranyl)-5,8-Decadienoic acid (see all 15)81276-02-0--
    11,14,15-THETA(5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoic acid (see all 8)----
    11H-14,15-EETA14,15-Ep-11-HETrE (see all 11)219535-29-2--
    11beta-Hydroxytestosterone11beta,17beta-dihydroxyandrost-4-en-3-one 1816-85-9--
    12,13-EpOMEVernolic acid (see all 12)----
    13-HETE13-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoate (see all 2)151910-72-4--
    14,15-Epoxy-5,8,11-eicosatrienoic acid(5Z,8Z,11Z)-14,15-Epoxyicosa-5.8.11-trienoic acid (see all 11)81276-03-1--
    15(S)-HPETE(5Z,8Z,11Z,13E)-(15S)-15-Hydroperoxyicosa-5,8,11,13-tetraenoate (see all 8)70981-96-3--

    10/31 DrugBank Compounds for CYP2C18 (see all 31)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Aminophenazone4-Dimethylaminoantipyrine (see all 3)58-15-1enzymesubstrate19934256 19515014
    IfosfamideAsta Z 4942 (see all 10)3778-73-2enzymesubstrate19934256 10348794
    Warfarin-- 81-81-2enzymesubstrate19934256 19515014
    4-METHYL-N-METHYL-N-(2-PHENYL-2H-PYRAZOL-3-YL)BENZENESULFONAMIDE-- --target--10592235
    AntipyrineAcetasol (see all 14)60-80-0enzymesubstrate19934256
    BuprenorphineBuprenophine (see all 4)52485-79-7enzymesubstrate19934256
    Clobazam-- 22316-47-8enzymesubstrate19934256
    Clotiazepam-- 33671-46-4enzymesubstrate19934256
    Cyclophosphamide-- 6055-19-2enzymesubstrate19934256
    DapsoneAcedapsone (see all 29)80-08-0enzymesubstrate19934256

    5 Novoseek chemical compound relationships for CYP2C18 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tolbutamide 60.2 3 15301741 (2), 12378636 (1)
    diclofenac 36.7 1 12972955 (1)
    omeprazole 33.6 8 8894508 (6)
    rifampicin 25.8 1 11714868 (1)
    oligonucleotide 7.98 1 11714868 (1)

    Search CenterWatch for drugs/clinical trials and news about CYP2C18 / CP2CI 

    Transcripts
    for CYP2C18 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CYP2C18 gene (2 alternative transcripts): 
    NM_000772.2  NM_001128925.1  

    Unigene Cluster for CYP2C18:

    Cytochrome P450, family 2, subfamily C, polypeptide 18
    Hs.511872  [show with all ESTs]
    Unigene Representative Sequence: NM_000772
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000476630 ENST00000285979(uc001kjv.4) ENST00000339022(uc001kjw.4)


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    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    AK223510.1 AK308558.1 AK313403.1 BC069666.1 BC096257.1 BC096258.1 BC096260.1 BX538127.1 
    M61853.1 M61856.1 

    5 DOTS entries:

    DT.207532  DT.314631  DT.101984877  DT.121632500  DT.91688282 

    18 AceView cDNA sequences:

    CB217056 CD013963 CD013966 CD013964 CD013962 CD013965 L07093 CB158473 
    NM_000769 BX538127 AW192911 BM969011 M61854 BG545330 CB161988 AV688442 
    M61858 X65962 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for CYP2C18    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b
    SP1:                                                                              
    SP2:                                                                              
    SP3:                                            -                                 
    SP4:        -     -                                                               


    ECgene alternative splicing isoforms for CYP2C18

    Expression
    for CYP2C18 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CYP2C18 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TCTAAATATA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See CYP2C18 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CYP2C18

    SOURCE GeneReport for Unigene cluster: Hs.511872
        SABiosciences Expression via Pathway-Focused PCR Array including CYP2C18: 
              Drug Metabolism: Phase I Enzymes in human mouse rat

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    In Situ
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    Orthologs
    for CYP2C18 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for CYP2C18 gene from 4/12 species (see all 12)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves F1NAB8_CHICK6
    Q8QFT4_CHICK6
    (see all 3)    		 cytochrome P-450 2C45
    (see all 3)    		 57(a)
    53(a)
    (see all 3)    		 many ↔ many
    many ↔ many
    (see all 3)    		 6(18655325-18675791)
    6(17658074-17660908)
    lizard
    (Anolis carolinensis)    		 Reptilia --
    --
    (see all 17)    		 --
    		 62(a)
    59(a)
    (see all 17)    		 many ↔ many
    many ↔ many
    (see all 17)    		 AAWZ02038902(823-8873)
    1(16287752-16303321)
    African clawed frog
    (Xenopus laevis)    		 Amphibia MGC684502 hypothetical protein MGC68450 74.67(n)    BC060328.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii CU928854.16
    cyp2y36
    		 --
    cytochrome P450, family 2, subfamily Y, polypeptid...
    		 48(a)
    46(a)
    		 many ↔ many
    many ↔ many
    		 15(54297-58832)
    15(65144-71354)


    ENSEMBL Gene Tree for CYP2C18 (if available)
    TreeFam Gene Tree for CYP2C18 (if available) 

    Paralogs
    for CYP2C18 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CYP2C18 gene
    CYP2W12  CYP2C82  CYP2F12  CYP2A72  CYP2R12  CYP2U12  CYP2J22  CYP2E12  
    CYP2D62  CYP2B7P12  CYP2A62  CYP2B62  CYP2C192  CYP2S12  CYP2C92  CYP2A132  
    18/26 SIMAP similar genes for CYP2C18 using alignment to 2 protein entries:     CP2CI_HUMAN (see all proteins) (see all similar genes):
    CYP2C    CYP2C9    CYP2C19    CYP 2C    CYP2C8    DKFZp686I24235
    CYP2E1    CYP2A13    CYP2A6    CYP2A6V2    CYP2F1    CYP2B
    CYP2B7    CYP2A7    CYP2S1    CYP2B6    CYP2J2    CYP2W1

    CYP2C18 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for CYP2C18
    PGOHUM00000238505 PGOHUM00000238595 PGOHUM00000238895


    Genomic Variants
    for CYP2C18 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1048 NCBI SNPs in CYP2C18 are shown (see all 1048)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 10 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs171101921,2
    		C,F,H,--90068721(+) GAACAG/CTGTGG 2 -- us2k116Minor allele frequency- C:0.05NA NS EA 2152
    rs171101941,2
    		C,F,H,,--90068743(+) AGTGAG/AAAATG 2 -- us2k116Minor allele frequency- A:0.05NA NS EA 2074
    rs560241241,2
    		C,--90068964(+) TTTCAC/GGGGGT 2 -- us2k13Minor allele frequency- G:0.14WA CSA 122
    rs767053091,2
    		C,F,--90069029(+) TTTAAG/CATGAA 2 -- us2k11Minor allele frequency- C:0.02WA 118
    rs577135871,2
    		C,--90069060(+) TGTTTA/CGGCAG 2 -- us2k14Minor allele frequency- C:0.08WA CSA NA 242
    rs18107691,2
    		C,--90069602(+) aagggC/Ttggag 2 -- us2k11Minor allele frequency- T:0.00WA 2
    rs561945191,2
    		C,--90070702(+) TCAGGT/GTAATT 2 -- int12Minor allele frequency- G:0.33WA CSA 3
    rs127744241,2
    		C,H--90071043(+) TGATGT/GTCTGT 2 -- int15Minor allele frequency- G:0.00NS EA NA 422
    rs750381201,2
    		C,--90071189(+) CTATTG/TTCAAT 2 -- int10--------
    rs748720191,2
    		C,--90071202(+) CACTGA/CAATAA 2 -- int10--------

    HapMap Linkage Disequilibrium report for CYP2C18 (96442710 - 96495947 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for CYP2C18: --
    Human Gene Mutation Database (HGMD): CYP2C18

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for CYP2C18 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CYP2C18 for disorders           About GeneDecksing

    OMIM gene information: 601131    OMIM disorders: --

    11 diseases for CYP2C18:    About MalaCards
    malignant pleural mesothelioma    cholesterol    chronic lymphocytic leukemia    lymphocytic leukemia
    fibromyalgia    alzheimer's disease    leukemia    breast cancer
    esophagitis    adenocarcinoma    hepatitis

    Human Genome Epidemiology (HuGE) Navigator: CYP2C18 (14 documents)

    Export disorders for CYP2C18 gene to outside databases

    Publications
    for CYP2C18 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CYP2C18 gene, integrated from 9 sources (see all 73):
    (articles sorted by number of sources associating them with CYP2C18)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and expression of complementary DNAs for multiple members of the human cytochrome P450IIC subfamily. (PubMed id 2009263)1, 2, 3 Romkes M.... Goldstein J.A. (1991)
    2. Polymerase chain reaction-directed identification, cloning, and quantification of human CYP2C18 mRNA. (PubMed id 1896026)1, 3, 9 Furuya H....Gonzalez F.J. (1991)
    3. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Identification of human cytochrome P450s involved in the formation of all-trans-retinoic acid principal metabolites. (PubMed id 11093772)1, 7 Marill J....Chabot G.G. (2000)
    6. Gene structure and upstream regulatory regions of human CYP2C9 and CYP2C18. (PubMed id 8333835)1, 2 de Morais S.M.... Goldstein J.A. (1993)
    7. Cloning and expression of complementary DNAs for multiple members of the human cytochrome PH50IIC subfamily. (PubMed id 8095407)1, 2 Romkes M....Goldstein J.A. (1993)
    8. Establishment of a transgenic cell line stably expressing human cytochrome P450 2C18 and identification of a CYP2C18 clone with exon 5 missing. (PubMed id 12378636)1, 9 Zhu-Ge J....Li X. (2002)
    9. Regulation of human CYP2C18 and CYP2C19 in transgenic mice: influence of castration, testosterone, and growth hormone. (PubMed id 19339376)7, 9 LAPfgren S....Ingelman-Sundberg M. (2009)
    10. The human CYP2C locus: a prototype for intergenic and exon repetition splicing events. (PubMed id 10704292)1, 9 Finta C. and Zaphiropoulos P.G. (2000)

    External Searches for CYP2C18 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Genome Databases showing CYP2C18 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1562 HGNC: 2620 AceView: CYP2C19andCYP2C18 Ensembl:ENSG00000108242 euGenes: HUgn1562
    ECgene: CYP2C18 Kegg: 1562 H-InvDB: CYP2C18

    Other Databases showing CYP2C18 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CYP2C18 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CYP2C18 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CYP2C18 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for CYP2C18 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CYP2C18 gene:
    Search GeneIP for patents involving CYP2C18

    GeneCards and IP:
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