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CYP2C18 Gene

protein-coding   GIFtS: 66
GCID: GC10P096433

Cytochrome P450, Family 2, Subfamily C, Polypeptide 18

(Previous names: cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase),...)
(Previous symbol: CYP2C17)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cytochrome P450, Family 2, Subfamily C, Polypeptide 181 2     CYP2C2
CYP2C171 2     P450-6B/29C2
Cytochrome P450, Subfamily IIC (Mephenytoin 4-Hydroxylase), Polypeptide 181 2     P450IIC172
Cytochrome P450-6b/29c2 3     Cytochrome P450 2C182
CYPIIC182 3     Cytochrome P450, Subfamily IIC (Mephenytoin 4-Hydroxylase), Polypeptide 172
EC 1.14.14.13 8     Flavoprotein-Linked Monooxygenase2
(S)-Mephenytoin Hydroxylase Associated Cytochrome P4502     Microsomal Monooxygenase2
CPCI2     Unspecific Monooxygenase2

External Ids:    HGNC: 26201   Entrez Gene: 15622   Ensembl: ENSG000001082427   OMIM: 6011315   UniProtKB: P332603   

Export aliases for CYP2C18 gene to outside databases

Previous GC identifers: GC10P095336 GC10M095677 GC10P096576 GC10P096107 GC10P090071


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CYP2C18 Gene:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are
monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids
and other lipids. This protein localizes to the endoplasmic reticulum but its specific substrate has not yet been
determined. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. An additional
gene, CYP2C17, was once thought to exist; however, CYP2C17 is now considered an artefact based on a chimera of
CYP2C18 and CYP2C19. Alternatively spliced transcript variants encoding different isoforms have been found for
this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for CYP2C18 Gene:
CYP2C18 (cytochrome P450, family 2, subfamily C, polypeptide 18) is a protein-coding gene. GO annotations related to this gene include electron carrier activity and heme binding. An important paralog of this gene is CYP2W1.

UniProtKB/Swiss-Prot: CP2CI_HUMAN, P33260
Function: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is
involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated
compounds, including steroids, fatty acids, and xenobiotics

Gene Wiki entry for CYP2C18 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NC_018921.2  NT_030059.14  
Regulatory elements:
   Regulatory transcription factor binding sites in the CYP2C18 gene promoter:
         MyoD   NF-kappaB   MZF-1   NF-AT4   FOXC1   NF-AT3   NF-kappaB1   TGIF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCYP2C18 promoter sequence
   Search Chromatin IP Primers for CYP2C18

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CYP2C18


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q24   Ensembl cytogenetic band:  10q23.33   HGNC cytogenetic band: 10q24

CYP2C18 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CYP2C18 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P096433:  view genomic region     (about GC identifiers)

Start:
96,443,251 bp from pter      End:
96,495,947 bp from pter
Size:
52,697 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CP2CI_HUMAN, P33260 (See protein sequence)
Recommended Name: Cytochrome P450 2C18  
Size: 490 amino acids; 55711 Da
Cofactor: Heme group (By similarity)
1 PDB 3D structure from and Proteopedia for CYP2C18:
2H6P (3D)    
Secondary accessions: B2R8K2 Q16703 Q16751 Q4VAT5 Q6GRG1
Alternative splicing: 2 isoforms:  P33260-1   P33260-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CYP2C18: NX_P33260

Explore proteomics data for CYP2C18 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for CYP2C18 (P33260) (see all 30)
     PFSAGKR  QVCNNFP  FDPGHFL  TTILQNF 


    See CYP2C18 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_000763.1  NP_001122397.1  

    ENSEMBL proteins: 
     ENSP00000285979   ENSP00000341293  
    Reactome Protein details: P33260

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CYP: Cytochrome P450s

    IUPHAR Guide to PHARMACOLOGY protein family classification: CYP2C18
    CYP2 family

    3 InterPro protein domains:
     IPR001128 Cyt_P450
     IPR017972 Cyt_P450_CS
     IPR002401 Cyt_P450_E_grp-I

    Graphical View of Domain Structure for InterPro Entry P33260

    ProtoNet protein and cluster: P33260

    1 Blocks protein domain: IPB002401 E-class P450 group I signature

    UniProtKB/Swiss-Prot: CP2CI_HUMAN, P33260
    Similarity: Belongs to the cytochrome P450 family


    Find genes that share domains with CYP2C18           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CP2CI_HUMAN, P33260
    Function: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is
    involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated
    compounds, including steroids, fatty acids, and xenobiotics
    Catalytic activity: RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O
    Induction: P450 can be induced to high levels in liver and other tissues by various foreign compounds, including
    drugs, pesticides, and carcinogens

         Genatlas biochemistry entry for CYP2C18:
    cytochrome P450,subfamily IIC (mephenytoin 4-hydroxylase),polypeptide 18

         Enzyme Number (IUBMB): EC 1.14.14.11 2

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004497monooxygenase activity TAS8110777
    GO:0005506iron ion binding IEA--
    GO:0016705oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen ----
    GO:0019825oxygen binding TAS8110777
    GO:0020037heme binding IEA--
         
    Find genes that share ontologies with CYP2C18           About GenesLikeMe


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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CP2CI_HUMAN, P33260: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral
    membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    extracellular1
    golgi apparatus1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane TAS--

    Find genes that share ontologies with CYP2C18           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CYP2C18 About   (see all 9)  
    See pathways by source

    SuperPathContained pathways About
    1Cytochrome P450 - arranged by substrate type
    Cytochrome P450 - arranged by substrate type0.75
    cytochrome P4500.74
    Phase 1 - Functionalization of compounds0.75
    Xenobiotics0.00
    2Chemical carcinogenesis
    Chemical carcinogenesis0.71
    Benzo a pyrene metabolism0.00
    Retinol metabolism0.35
    3Biological oxidations
    Biological oxidations0.56
    metapathway biotransformation0.42
    4Tryptophan metabolism
    Tryptophan metabolism0.46
    5Gefitinib Pathway, Pharmacokinetics
    Warfarin Pathway, Pharmacokinetics0.45


    Find genes that share SuperPaths with CYP2C18           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 GeneGo (Thomson Reuters) Pathways for CYP2C18
        Retinol metabolism
    Benzo[a]pyrene metabolism

    4 BioSystems Pathways for CYP2C18
        cytochrome P450
    FOXA1 transcription factor network
    metapathway biotransformation
    Tryptophan metabolism


    1 Reactome Pathway for CYP2C18
        Xenobiotics

    1 PharmGKB Pathway for CYP2C18
        Warfarin Pathway, Pharmacokinetics

    3 Kegg Pathways  (Kegg details for CYP2C18):
        Retinol metabolism
    Serotonergic synapse
    Chemical carcinogenesis

        Pathway & Disease-focused RT2 Profiler PCR Array including CYP2C18: 
              Drug Metabolism: Phase I Enzymes in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CYP2C18

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CYP2C18 (P332603 ENSP000002859794) via UniProtKB, MINT, STRING, and/or I2D (see all 99)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    A2MP010233I2D: score=1 
    ECSITQ9BQ953I2D: score=1 
    ALDH1A1ENSP000002977854STRING: ENSP00000297785
    ALOX15ENSP000002937614STRING: ENSP00000293761
    CYP1A1ENSP000003690504STRING: ENSP00000369050
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006805xenobiotic metabolic process TAS--
    GO:0044281small molecule metabolic process TAS--
    GO:0055114oxidation-reduction process ----

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    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for CYP2C18 (CP2CI)

    Selected HMDB Compounds for CYP2C18 (see all 49)    About this table
    CompoundSynonyms CAS #PubMed Ids
    10-HETE10-hydroxyeicosa-all-cis-5,8,11,14-tetraenoate (see all 2)167697-52-1--
    11,12,15-THETA11,12,15-Trihydroxyicosatrienoic acid (see all 5)----
    11,12-Epoxyeicosatrienoic acid10-(3-(2-octenyl)oxiranyl)-5,8-Decadienoic acid (see all 15)81276-02-0--
    11,14,15-THETA(5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoic acid (see all 8)----
    11H-14,15-EETA14,15-Ep-11-HETrE (see all 11)219535-29-2--
    11beta-Hydroxytestosterone11beta,17beta-dihydroxyandrost-4-en-3-one 1816-85-9--
    12,13-EpOMEVernolic acid (see all 12)----
    13-HETE13-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoate (see all 2)151910-72-4--
    14,15-Epoxy-5,8,11-eicosatrienoic acid(5Z,8Z,11Z)-14,15-Epoxyicosa-5.8.11-trienoic acid (see all 11)81276-03-1--
    15(S)-HPETE(5Z,8Z,11Z,13E)-(15S)-15-Hydroperoxyicosa-5,8,11,13-tetraenoate (see all 8)70981-96-3--

    Selected DrugBank Compounds for CYP2C18 (see all 31)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Aminophenazone4-Dimethylaminoantipyrine (see all 3)58-15-1enzymesubstrate19934256 19515014
    Ifosfamide-- 3778-73-2enzymesubstrate19934256 10348794
    Warfarin-- 81-81-2enzymesubstrate19934256 19515014
    4-METHYL-N-METHYL-N-(2-PHENYL-2H-PYRAZOL-3-YL)BENZENESULFONAMIDE-- --target--10592235
    AntipyrineAcetasol (see all 14)60-80-0enzymesubstrate8681486
    BuprenorphineBuprenophine (see all 3)52485-79-7enzymesubstrate19934256
    ClobazamAedon (see all 23)22316-47-8enzymesubstrate19934256
    Clotiazepam-- 33671-46-4enzymesubstrate19934256
    CyclophosphamideCPM (see all 5)50-18-0enzymesubstrate19934256
    Dapsone1,1'-Sulfonylbis[4-aminobenzene] (see all 8)80-08-0enzymesubstrate19934256

    5 Novoseek inferred chemical compound relationships for CYP2C18 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tolbutamide 60.2 3 15301741 (2), 12378636 (1)
    diclofenac 36.7 1 12972955 (1)
    omeprazole 33.6 8 8894508 (6)
    rifampicin 25.8 1 11714868 (1)
    oligonucleotide 7.98 1 11714868 (1)



    Find genes that share compounds with CYP2C18           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CYP2C18 gene (2 alternative transcripts): 
    NM_000772.2  NM_001128925.1  

    Unigene Cluster for CYP2C18:

    Cytochrome P450, family 2, subfamily C, polypeptide 18
    Hs.511872  [show with all ESTs]
    Unigene Representative Sequence: NM_000772
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000285979(uc001kjv.4) ENST00000339022(uc001kjw.4)
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    Additional mRNA sequence: 

    AK223510.1 AK308558.1 AK313403.1 BC069666.1 BC096257.1 BC096258.1 BC096260.1 BX538127.1 
    M61853.1 M61856.1 

    5 DOTS entries:

    DT.207532  DT.314631  DT.101984877  DT.121632500  DT.91688282 

    18 AceView cDNA sequences:

    CD013962 CD013964 CB217056 CD013965 CD013963 CD013966 L07093 AW192911 
    BG545330 BX538127 NM_000769 BM969011 M61854 CB158473 CB161988 AV688442 
    M61858 X65962 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for CYP2C18    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b
    SP1:                                                                              
    SP2:                                                                              
    SP3:                                            -                                 
    SP4:        -     -                                                               


    ECgene alternative splicing isoforms for CYP2C18

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CYP2C18 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTAAATATA
    CYP2C18 Expression
    About this image

    CYP2C18 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CYP2C18 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.511872
        Pathway & Disease-focused RT2 Profiler PCR Array including CYP2C18: 
              Drug Metabolism: Phase I Enzymes in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CYP2C18 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cyp2c505
    Cyp2c551
    cytochrome P450, family 2, subfamily c, polypeptide more1, 5 82(n)1
    76.28(a)1
      19 (34.24 cM)5
    720821  NM_028089.31  NP_082365.11 
     400896885 
    chicken
    (Gallus gallus)
    Aves CYP2C451 cytochrome P-450 2C45 63.48(n)
    58.09(a)
      414833  NM_001001752.1  NP_001001752.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC684502 hypothetical protein MGC68450 74.67(n)    BC060328.1 
    mosquito
    (Anopheles gambiae)
    Insecta AgaP_AGAP0030671 AgaP_AGAP003067 43.38(n)
    31.07(a)
      1273741  XM_312753.5  XP_312753.5 


    ENSEMBL Gene Tree for CYP2C18 (if available)
    TreeFam Gene Tree for CYP2C18 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CYP2C18 gene
    CYP2W12  CYP2C82  CYP2A62  CYP2F12  CYP2A72  CYP2B62  CYP2C192  CYP2R12  
    CYP2J22  CYP2U12  CYP2S12  CYP2E12  CYP2C92  CYP2D62  CYP2A132  
    Selected SIMAP similar genes for CYP2C18 using alignment to 2 protein entries:     CP2CI_HUMAN (see all proteins) (see all similar genes):
    CYP2C    CYP2C19    CYP2C9    CYP 2C    CYP2C8    DKFZp686I24235
    CYP2E1    CYP2A13    CYP2A6    CYP2A6V2    CYP2F1    CYP2B
    CYP2B7    CYP2A7    CYP2S1    CYP2B6    CYP2J2    CYP2W1

    Find genes that share paralogs with CYP2C18           About GenesLikeMe


    3 Pseudogenes.org Pseudogenes for CYP2C18
    PGOHUM00000238505 PGOHUM00000238595 PGOHUM00000238895


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CYP2C18 (see all 1230)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2017657451,2
    C--90079216(+) TTACT-/GGGTAT 2 -- int10--------
    rs106699731,2
    C--90093672(+) CAATTATA/-ATATG 2 -- cds13Minor allele frequency- -:0.10CSA 10
    rs1384179501,2
    C--90108482(+) TCATC-/TGTTGATG 2 -- int10--------
    rs771411681,2
    --90108484(+) ATCTGA/C/TTGATG 2 -- int10--------
    rs557205771,2
    C--96445258(+) CTATA-/ATGGTT 2 -- int10--------
    rs793893491,2
    C,F--96446254(+) TGATCT/CTAGAG 2 -- int11Minor allele frequency- C:0.03WA 118
    rs1447232001,2
    C--96452172(+) ACATG-/AAAAAA 2 -- int10--------
    rs1132977901,2
    F--96455054(+) TACCCG/CCAATC 2 -- int11Minor allele frequency- C:0.50CSA 2
    rs584240171,2
    --96455566(+) GATCTC/TAGCAA 2 -- int10--------
    rs42698531,2
    C--96458726(+) ctctgA/Gaattg 2 -- int12Minor allele frequency- G:0.00NA 4

    HapMap Linkage Disequilibrium report for CYP2C18 (96443251 - 96495947 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for CYP2C18:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2739707CNV Deletion23290073
    esv2657299CNV Deletion23128226
    esv2672446CNV Deletion23128226
    nsv7496CNV Insertion18451855
    nsv522538CNV Loss19592680
    nsv895901CNV Loss21882294

    Human Gene Mutation Database (HGMD): CYP2C18
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CYP2C18
    DNA2.0 Custom Variant and Variant Library Synthesis for CYP2C18

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601131    OMIM disorders: --


    Find genes that share disorders with CYP2C18           About GenesLikeMe

    Genetic Association Database (GAD): CYP2C18
    Human Genome Epidemiology (HuGE) Navigator: CYP2C18 (14 documents)

    Export disorders for CYP2C18 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CYP2C18 gene, integrated from 10 sources (see all 78):
    (articles sorted by number of sources associating them with CYP2C18)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and expression of complementary DNAs for multiple members of the human cytochrome P450IIC subfamily. (PubMed id 2009263)1, 2, 3 Romkes M.... Goldstein J.A. (Biochemistry 1991)
    2. Polymerase chain reaction-directed identification, cloning, and quantification of human CYP2C18 mRNA. (PubMed id 1896026)1, 3, 9 Furuya H....Gonzalez F.J. (Mol. Pharmacol. 1991)
    3. A genome-wide association study of acenocoumarol maintenance dosage. (PubMed id 19578179)1, 4, 9 Teichert M....Stricker B.H. (Hum. Mol. Genet. 2009)
    4. Association of warfarin dose with genes involved in its action and metabolism. (PubMed id 17048007)1, 4, 9 Wadelius M....Deloukas P. (Hum. Genet. 2007)
    5. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PubMed id 20453000)1, 4 Liu C.Y....Christiani D.C. (Carcinogenesis 2010)
    6. Novel DNA sequence variations of cytochrome P450 genes in the Han Chinese population. (PubMed id 19290787)1, 4 Wang H.H....Chen Y.T. (Pharmacogenomics 2009)
    7. Genetic determinants of warfarin dosing in the Han-Chinese population. (PubMed id 19958090)1, 4 Lee M.T....Chen Y.T. (Pharmacogenomics 2009)
    8. Risk of malignant pleural mesothelioma and polymorphisms in genes involved in the genome stability and xenobiotics metabolism. (PubMed id 19751749)1, 4 Gemignani F....Landi S. (Mutat. Res. 2009)
    9. Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease. (PubMed id 19204726)1, 4 Chapuis J....Lambert J.C. (Mol. Psychiatry 2009)
    10. Influence of the genetic polymorphisms in the 5' flanking and exonic regions of CYP2C19 on proguanil oxidation. (PubMed id 20045989)1, 4 Satyanarayana C.R....Chandrasekaran A. (Drug Metab. Pharmacokinet. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1562 HGNC: 2620 AceView: CYP2C19andCYP2C18 Ensembl:ENSG00000108242 euGenes: HUgn1562
    ECgene: CYP2C18 Kegg: 1562 H-InvDB: CYP2C18

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CYP2C18 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CYP2C18 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CYP2C18 gene:
    Search GeneIP for patents involving CYP2C18

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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