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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CYP2B7P1 Gene

pseudogene GIFtS: 33
GCID: GC19P041430

cytochrome P450, family 2, subfamily B, polypeptide 7 pseudogene...

(Previous names: cytochrome P450, family 2, subfamily B, polypeptide 7 pseudogene...)
(Previous symbol: CYP2B7)

Search for CYP2B7P1
in

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our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Cytochrome P450, Family 2, Subfamily B, Polypeptide 7 Pseudogene 1¹ ²
CYP2B7¹ ² ⁴
CYP2B¹ ²
CYP2B7P¹ ²
Cytochrome P450, Family 2, Subfamily B, Polypeptide 7 Pseudogene¹
Cytochrome P450 2B7 Short Isoform⁴

External Ids:	HGNC: 2616¹	Entrez Gene: 1556²	Ensembl: ENSG00000256612⁷	UniProtKB: Q14097⁴

ORGUL members:
	NONCODE:n405257

Export aliases for CYP2B7P1 gene to outside databases

Previous GC identifer: GC19P046131

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000019.9 NC_018930.1 NT_011109.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CYP2B7P1 gene promoter:
AML1a GR-beta AREB6 CREB POU2F1 POU2F1a deltaCREB STAT3 GR-alpha ZIC2/Zic2
Other transcription factors

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Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CYP2B7P1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.2 Ensembl cytogenetic band: 19q13.2 HGNC cytogenetic band: 19q13.2

CYP2B7P1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CYP2B7P1 gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19P041430: view genomic region (about GC identifiers)

Start:	41,430,172 bp from pter	End:	41,456,563 bp from pter
Size:	26,392 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
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About This Section

UniProtKB/TrEMBL: Q14097 (See protein sequence)

Recommended Name: CYP2B protein

Size: 377 amino acids; 43148 Da

CYP2B7P1 Protein expression data from MOPED and PaxDb: --

ENSEMBL proteins:

ENSP00000441190

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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005575	cellular_component	--	--

CYP2B7P1 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CYP2B7P1 for domains About GeneDecksing

3 InterPro domains/families:

IPR008068 Cyt_P450_E_grp-I_CYP2B-like

IPR001128 Cyt_P450

IPR002401 Cyt_P450_E_grp-I

Graphical View of Domain Structure for InterPro Entry Q14097

ProtoNet protein and cluster: Q14097

UniProtKB/TrEMBL: Q14097

Similarity: Belongs to the cytochrome P450 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

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Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004497	monooxygenase activity	--	--
GO:0009055	electron carrier activity	--	--
GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	--	--
GO:0020037	heme binding	--	--

CYP2B7P1 for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for CYP2B7P1

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0055114	oxidation-reduction process	--	--

CYP2B7P1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

Unigene Cluster for CYP2B7P1:

Cytochrome P450, family 2, subfamily B, polypeptide 7 pseudogene 1

Hs.529117 [show with all ESTs]

Unigene Representative Sequence: NR_001278

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000541697(uc010ehg.1 uc010ehh.1 uc002opq.3)

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Additional cDNA sequence:

AK307933.1 AK310944.1 BC041174.1 DQ198366.1 DQ198367.1 M29873.1 NR_001278.1

9 DOTS entries:

DT.92430531 DT.87046467 DT.92422432 DT.121503332 DT.101974577 DT.86851136 DT.101982026 DT.75117033

DT.100766435

24/536 AceView cDNA sequences (see all 536):

AI084234 BQ574998 AL709955 AA903776 BU956420 AW176373 CA454230 BM833977

BE501221 CA420401 BC001723 N40470 BQ023519 BQ067370 NM_080732 BQ052246

AA377558 AI110596 AA994838 CB152107 AI094393 CB154530 BX281760 BQ689426

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CYP2B7P1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACCTCCCCAC

About this image

CYP2B7P1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

Hepatocytes (Primary Cell)

Liver

Alveolar type II cells (Derivation of mature...)

Lung

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Genevestigator expression for CYP2B7P1

SOURCE GeneReport for Unigene cluster: Hs.529117

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

--

ENSEMBL Gene Tree for CYP2B7P1 (if available)
TreeFam Gene Tree for CYP2B7P1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CYP2B7P1 gene

CYP2W1² CYP2C8² CYP2F1² CYP2A7² CYP2R1² CYP2U1² CYP2J2² CYP2E1²

CYP2D6² CYP2A6² CYP2B6² CYP2C19² CYP2S1² CYP2C9² CYP2C18² CYP2A13²

CYP2B7P1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs190984272^1,2		--	41428261(+)	`GACGCC/TGGCCT`	1	--	us2k¹		0	--	--	--	--
rs115830880^1,2	C,F,	--	41428337(+)	`AACAGG/ATTGGG`	1	--	us2k¹		1		WA	118
rs183126754^1,2		--	41428407(+)	`AACGTA/CCTGTG`	1	--	us2k¹		0	--	--	--	--
rs11083589^1,2	C,F,A,H,	--	41428416(+)	`TGCCCA/G/TGATGT`	1	--	us2k¹		9		NA WA EA	370
rs185873040^1,2		--	41428508(+)	`TATCTA/CGCTTC`	1	--	us2k¹		0	--	--	--	--
rs139368546^1,2		--	41428522(+)	`CCACCA/GGGTGG`	1	--	us2k¹		0	--	--	--	--
rs3933911^1,2	C,F,H,	--	41428583(+)	`ACATTC/GCATTC`	1	--	us2k¹		6		NA CSA	12
rs138374547^1,2		--	41428615(+)	`AAGCC-/TTCCTC`	1	--	us2k¹		0	--	--	--	--
rs11083590^1,2	C,F,H,	--	41428626(+)	`TTATCT/CCAACT`	1	--	us2k¹		7		NA CSA	14
rs191769422^1,2		--	41428772(+)	`ATACCC/TAGGCT`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for CYP2B7P1 (41430172 - 41456563 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 11 variations for CYP2B7P1
11 CNVs: 53651 1299 102842 38382 4081 50145 3191 89241 89240 30076 50144

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CYP2B7P1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with CYP2B7P1)

Utopia: connect your pdf to the dynamic
world of online information

Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants. (PubMed id 15128046)^{1, 3} Nelson D.R....Nebert D.W. (2004)
A genetic polymorphism in coumarin 7-hydroxylation: sequence of the human CYP2A genes and identification of variant CYP2A6 alleles. (PubMed id 7668294)^{1, 3} Fernandez-Salguero P.... Idle J.R. (1995)
Partial deletion of CYP2B6 owing to unequal crossover with CYP2B7. (PubMed id 17885627)¹ Rotger M....Telenti A. (2007)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
cDNA cloning and sequence and cDNA-directed expression of human P450 IIB1: identification of a normal and two variant cDNAs derived from the CYP2B locus on chromosome 19 and differential expression of the IIB mRNAs in human liver. (PubMed id 2573390)¹ Yamano S.... Gonzalez F.J. (1989)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 1556	HGNC: 2616	AceView: EGLN2andCYP2B7	Ensembl:ENSG00000256612	euGenes: HUgn1556
ECgene: CYP2B7P1	H-InvDB: CYP2B7P1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CYP2B7P1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for CYP2B7P1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for CYP2B7P1 gene:
Search GeneIP for patents involving CYP2B7P1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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CYP2B7P1 Gene

cytochrome P450, family 2, subfamily B, polypeptide 7 pseudogene...

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CYP2B7P1 Gene

cytochrome P450, family 2, subfamily B, polypeptide 7 pseudogene...

Aliasesfor CYP2B7P1 gene

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Genomic Viewsfor CYP2B7P1 gene

Proteinsfor CYP2B7P1 gene

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External Searches for CYP2B7P1 gene

Genome Databases showing CYP2B7P1 gene

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for CYP2B7P1 gene

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for CYP2B7P1 gene

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for CYP2B7P1 gene

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for CYP2B7P1 gene

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for CYP2B7P1 gene

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for CYP2B7P1 gene

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for CYP2B7P1 gene

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for CYP2B7P1 gene

Expression
for CYP2B7P1 gene

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for CYP2B7P1 gene

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