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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CYP2B7P1 Gene

pseudogene   GIFtS: 28
GCID: GC19P041430

Cytochrome P450, Family 2, Subfamily B, Polypeptide 7 Pseudogene...

(Previous names: cytochrome P450, family 2, subfamily B, polypeptide 7 pseudogene)
(Previous symbol: CYP2B7)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Cytochrome P450, Family 2, Subfamily B, Polypeptide 7 Pseudogene 11 2
CYP2B71 2
Cytochrome P450, Family 2, Subfamily B, Polypeptide 7 Pseudogene1
CYP2B2
CYP2B7P2

External Ids:    HGNC: 26161   Entrez Gene: 15562   Ensembl: ENSG000002566127   
ORGUL members:         
NONCODE14:n405257      

Export aliases for CYP2B7P1 gene to outside databases

Previous GC identifer: GC19P046131


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for CYP2B7P1 Gene: 
CYP2B7P1 (cytochrome P450, family 2, subfamily B, polypeptide 7 pseudogene 1) is a pseudogene, and is affiliated with the lncRNA class. Diseases associated with CYP2B7P1 include cytochrome p450.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.2  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CYP2B7P1 gene promoter:
         AML1a   GR-beta   AREB6   CREB   POU2F1   POU2F1a   deltaCREB   STAT3   GR-alpha   ZIC2/Zic2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for CYP2B7P1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CYP2B7P1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.2   Ensembl cytogenetic band:  19q13.2   HGNC cytogenetic band: 19q13.2

CYP2B7P1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CYP2B7P1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P041430:  view genomic region     (about GC identifiers)

Start:
41,430,124 bp from pter      End:
41,456,565 bp from pter
Size:
26,442 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB: --


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
CYP: Cytochrome P450s

  --

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Animal Models:
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CYP2B7P1

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
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Browse Tocris compounds for CYP2B7P1

Search CenterWatch for drugs/clinical trials and news about CYP2B7P1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

Unigene Cluster for CYP2B7P1:

Cytochrome P450, family 2, subfamily B, polypeptide 7 pseudogene 1
Hs.529117  [show with all ESTs]
Unigene Representative Sequence: NR_001278
6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000593298 ENST00000599831 ENST00000599198 ENST00000541697(uc010ehg.1 uc010ehh.1 uc002opq.3)
ENST00000602646 ENST00000600518
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Additional mRNA sequence: 

AK307933.1 AK310944.1 BC041174.1 DQ198366.1 DQ198367.1 M29873.1 NR_001278.1 

9 DOTS entries:

DT.92430531  DT.87046467  DT.92422432  DT.121503332  DT.101974577  DT.86851136  DT.101982026  DT.75117033 
DT.100766435 

24/536 AceView cDNA sequences (see all 536):

BC036051 BU157872 BQ052246 BX479819 BM912250 BM423651 NM_080732 BM752532 
BQ689426 CR623538 BQ706107 CB126712 AA377558 BG034561 BX104336 CB153988 
AL709955 AI570301 CA426400 BQ691651 AI349566 BF940551 AW176373 AA425231 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CYP2B7P1 expression in normal human tissues (normalized intensities)      CYP2B7P1 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: ACCTCCCCAC
CYP2B7P1 Expression
About this image


CYP2B7P1 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/5 selected tissues (see all 5) fully expand
 
 Breast (Uncategorized)
         MAMMARY GLAND   
 
 Liver (Hepatobiliary System)
         Hepatocytes
 
 Inner Cell Mass (Early Embryonic Tissues)
         Line H9 (WA09)
 
 Spinal Cord (Nervous System)
         Superior Cervical Ganglion   
 
 Lung (Respiratory System)

Genevestigator expression for CYP2B7P1

SOURCE GeneReport for Unigene cluster: Hs.529117
    SABiosciences Custom PCR Arrays for CYP2B7P1
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In Situ
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYP2B7P1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section
  --

ENSEMBL Gene Tree for CYP2B7P1 (if available)
TreeFam Gene Tree for CYP2B7P1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/732 SNPs in CYP2B7P1 are shown (see all 732)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 19 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1909842721,2
--41428261(+) GACGCC/TGGCCT 1 -- us2k10--------
rs1158308801,2
C,F--41428337(+) AACAGG/ATTGGG 1 -- us2k11Minor allele frequency- A:0.18WA 118
rs1831267541,2
--41428407(+) AACGTA/CCTGTG 1 -- us2k10--------
rs110835891,2
C,F,A,H--41428416(+) tgcccA/G/Tgatgt 1 -- us2k19NA WA EA 370
rs1858730401,2
--41428508(+) TATCTA/CGCTTC 1 -- us2k10--------
rs1393685461,2
--41428522(+) CCACCA/GGGTGG 1 -- us2k10--------
rs39339111,2
C,F,H--41428583(+) acattC/Gcattc 1 -- us2k16Minor allele frequency- G:0.33NA CSA 12
rs1383745471,2
--41428615(+) AAGCC-/TTCCTC 1 -- us2k10--------
rs110835901,2
C,F,H--41428626(+) ttatcT/Ccaact 1 -- us2k17Minor allele frequency- C:0.36NA CSA 14
rs1917694221,2
--41428772(+) ATACCC/TAGGCT 1 -- us2k10--------

HapMap Linkage Disequilibrium report for CYP2B7P1 (41430124 - 41456565 bp)

Structural Variations
     Database of Genomic Variants (DGV) 10/16 variations for CYP2B7P1 (see all 16):    About this table     
Variant IDTypeSubtypePubMed ID
esv2718571CNV Deletion23290073
esv2718572CNV Deletion23290073
esv2658055CNV Deletion23128226
nsv509743CNV Insertion20534489
esv2597443CNV Loss19546169
dgv55n17CNV Loss16327808
dgv408n27CNV Loss19166990
nsv433319CNV Loss18776910
nsv517597CNV Loss19592680
nsv470141CNV Loss18288195

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
2 diseases for CYP2B7P1:    About MalaCards
cytochrome p450    


CYP2B7P1 for disorders           About GeneDecksing


Export disorders for CYP2B7P1 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for CYP2B7P1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with CYP2B7P1)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants. (PubMed id 15128046)1, 3 Nelson D.R....Nebert D.W. (2004)
  2. A genetic polymorphism in coumarin 7-hydroxylation: sequence of the human CYP2A genes and identification of variant CYP2A6 alleles. (PubMed id 7668294)1, 3 Fernandez-Salguero P.... Idle J.R. (1995)
  3. Partial deletion of CYP2B6 owing to unequal crossover with CYP2B7. (PubMed id 17885627)1 Rotger M....Telenti A. (2007)
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
  5. cDNA cloning and sequence and cDNA-directed expression of human P450 IIB1: identification of a normal and two variant cDNAs derived from the CYP2B locus on chromosome 19 and differential expression of the IIB mRNAs in human liver. (PubMed id 2573390)1 Yamano S.... Gonzalez F.J. (1989)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 1556 HGNC: 2616 AceView: EGLN2andCYP2B7 Ensembl:ENSG00000256612 euGenes: HUgn1556
ECgene: CYP2B7P1 H-InvDB: CYP2B7P1

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for CYP2B7P1 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for CYP2B7P1 gene:
Search GeneIP for patents involving CYP2B7P1

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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