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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CYP2B6 Gene

protein-coding GIFtS: 67
GCID: GC19P041497

cytochrome P450, family 2, subfamily B, polypeptide 6

(Previous names: cytochrome P450, subfamily IIB (phenobarbital-inducible),...)
(Previous symbol: CYP2B)

Explore 56 diseases affiliated with
CYP2B6 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Cytochrome P450, Family 2, Subfamily B, Polypeptide 6¹ ²		CYP2B7²
CYPIIB6¹ ² ³		CYP2B7P²
CYP2B¹ ² ⁵		EFVM²
CPB6¹ ²		IIB1²
Cytochrome P450, Subfamily IIB (Phenobarbital-Inducible), Polypeptide 6¹ ²		P450²
Cytochrome P450 IIB1² ³		Cytochrome P450 2B6²
1,4-Cineole 2-Exo-Monooxygenase² ³		EC 1.14.13.-³
Cytochrome P450, Family 2, Subfamily B¹		EC 1.14.14.1⁸
Cytochrome P450, Subfamily IIB (Phenobarbital-Inducible)¹

External Ids:	HGNC: 2615¹	Entrez Gene: 1555²	Ensembl: ENSG00000197408⁷	OMIM: 123930⁵	UniProtKB: P20813³

Export aliases for CYP2B6 gene to outside databases

Previous GC identifers: GC19P042136 GC19P041888 GC19P046107 GC19P046123 GC19P046127 GC19P046189 GC19P037929

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CYP2B6:

This gene, CYP2B6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are

monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and

other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The

enzyme is known to metabolize some xenobiotics, such as the anti-cancer drugs cyclophosphamide and ifosphamide.

Transcript variants for this gene have been described; however, it has not been resolved whether these transcripts are

in fact produced by this gene or by a closely related pseudogene, CYP2B7. Both the gene and the pseudogene are located

in the middle of a CYP2A pseudogene found in a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F

subfamilies on chromosome 19q. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CP2B6_HUMAN, P20813

Function: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in

an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including

steroids, fatty acids, and xenobiotics. Acts as a 1,4-cineole 2-exo-monooxygenase

Gene Wiki entry for CYP2B6

PharmGKB "VIP" summary for CYP2B6

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000019.9 NC_018930.1 NT_011109.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CYP2B6 gene promoter:
GR TBP NF-kappaB c-Ets-1 TFIID GR-alpha MRF-2 NF-kappaB1 ATF
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CYP2B6 promoter sequence

Search SABiosciences Chromatin IP Primers for CYP2B6

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CYP2B6

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.2 Ensembl cytogenetic band: 19q13.2 HGNC cytogenetic band: 19q13.2

CYP2B6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CYP2B6 gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19P041497: view genomic region (about GC identifiers)

Start:	41,497,204 bp from pter	End:	41,524,301 bp from pter
Size:	27,098 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CP2B6_HUMAN, P20813 (See protein sequence)

Recommended Name: Cytochrome P450 2B6

Size: 491 amino acids; 56278 Da

Cofactor: Heme group

Cofactor: Heme group (By similarity)

Subcellular location: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral

membrane protein

4 PDB 3D structures from and Proteopedia for CYP2B6:

3IBD (3D)

3QOA (3D)

3QU8 (3D)

3UA5 (3D)

Secondary accessions: Q2V565 Q9UK46

Explore the universe of human proteins at neXtProt for CYP2B6: NX_P20813

Post-translational modifications:

Phosphorylation is accompanied by a decrease in enzyme activity (By similarity)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P20813

4/14 DME Specific Peptides for CYP2B6 (P20813) (see all 14)

TTILQNF

DRAKMPY

PGPRPLP

FGMGKRS

CYP2B6 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_000758.1

ENSEMBL proteins:

ENSP00000324648 ENSP00000330650

Reactome Protein details: P20813
Human Recombinant Protein Products:

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	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for CYP2B6

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005783	endoplasmic reticulum	NAS	--
GO:0005789	endoplasmic reticulum membrane	TAS	--
GO:0005792	microsome	--	--
GO:0043231	intracellular membrane-bounded organelle	NAS	--

CYP2B6 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for CYP2B6

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CYP2B6 for domains About GeneDecksing

4 InterPro domains/families:

IPR008068 Cyt_P450_E_grp-I_CYP2B-like

IPR001128 Cyt_P450

IPR017972 Cyt_P450_CS

IPR002401 Cyt_P450_E_grp-I

Graphical View of Domain Structure for InterPro Entry P20813

ProtoNet protein and cluster: P20813

2 Blocks protein families:

IPB002401 E-class P450 group I signature

IPB008068 CYP2B P450 family signature

UniProtKB/Swiss-Prot: CP2B6_HUMAN, P20813

Similarity: Belongs to the cytochrome P450 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: CP2B6_HUMAN, P20813

Function: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in

an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including

steroids, fatty acids, and xenobiotics. Acts as a 1,4-cineole 2-exo-monooxygenase

Catalytic activity: 1,4-cineole + NADPH + O(2) = 2-exo-hydroxy-1,4-cineole + NADP(+) + H(2)O

Biophysicochemical properties: Kinetic parameters: KM=360 uM for 1,4-cineole; Vmax=3.4 nmol/min/nmol enzyme toward

2-exo-hydroxy-1,4-cineole;

Induction: By phenobarbital

Enzyme Numbers (IUBMB): EC 1.14.14.1² EC 1.14.13.-¹

miRNA Products:		OriGene 3'-UTR Clone: CYP2B6 Browse MicroRNA Expression Plasmids
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		hsa-miR-1266 hsa-miR-3622b-3p hsa-miR-3613-3p hsa-miR-616* hsa-miR-1827 hsa-miR-373*
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Gene Editing
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In Situ Assay
Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for CYP2B6

Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004497	monooxygenase activity	IDA	19651758
GO:0005506	iron ion binding	IEA	--
GO:0009055	electron carrier activity	IEA	--
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	--	--
GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	IEA	--

CYP2B6 for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for CYP2B6:

Decreased Hepatitis C virus re

Synthetic lethal with imatinib

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/15 super-pathways (see all 15) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Ifosfamide Pathway, Pharmacokinetics

Ifosfamide Pathway, Pharmacokinetics	1.00	Nevirapine Pathway, Pharmacokinetics	0.50
Cyclophosphamide Pathway, Pharmacokinetics	0.86	Artemisinin and Derivatives Pathway, Pharmacokinetics	0.50
Sorafenib Pharmacokinetics	0.50	Clopidogrel Pathway, Pharmacokinetics	0.36

Xenobiotics

	Xenobiotics	1.00			Phenytoin Pathway, Pharmacokinetics	0.42
	CYP2E1 reactions	0.65			Carbamazepine Pathway, Pharmacokinetics	0.38

Cytochrome P450 - arranged by substrate type

	Cytochrome P450 - arranged by substrate type	1.00			cytochrome P450	0.73
	Phase 1 - Functionalization of compounds	0.74

Drug metabolism - cytochrome P450

	Drug metabolism - cytochrome P450	1.00			Retinol metabolism	0.40
	Metabolism of xenobiotics by cytochrome P450	0.73

Retinol metabolism

Retinol metabolism

1.00

Retinol metabolism

0.95

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for CYP2B6

Retinol metabolism

2 GeneGo (Thomson Reuters) Pathways for CYP2B6

	Retinol metabolism
	2-Naphthylamine and 2-Nitronaphtalene metabolism

5 BioSystems Pathways for CYP2B6

	cytochrome P450
	Nuclear receptors in lipid metabolism and toxicity
	bupropion degradation
	Nicotine metabolism
	metapathway biotransformation

5/6 Reactome Pathways for CYP2B6 (see all 6)

	Cytochrome P450 - arranged by substrate type
	Xenobiotics
	Metabolism
	Biological oxidations
	Phase 1 - Functionalization of compounds

5/12 PharmGKB Pathways for CYP2B6 (see all 12)

	Artemisinin and Derivatives Pathway, Pharmacokinetics
	Carbamazepine Pathway, Pharmacokinetics
	Clopidogrel Pathway, Pharmacokinetics
	Cyclophosphamide Pathway, Pharmacokinetics
	Ifosfamide Pathway, Pharmacokinetics

5 Kegg Pathways (Kegg details for CYP2B6):

	Arachidonic acid metabolism
	Retinol metabolism
	Metabolism of xenobiotics by cytochrome P450
	Drug metabolism - cytochrome P450
	Metabolic pathways

CYP2B6 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CYP2B6

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/103 Interacting proteins for CYP2B6 (ENSP00000324648⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 103)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ADH1A	ENSP00000209668⁴	STRING: ENSP00000209668
ADH1B	ENSP00000306606⁴	STRING: ENSP00000306606
ADH4	ENSP00000265512⁴	STRING: ENSP00000265512
ADH5	ENSP00000296412⁴	STRING: ENSP00000296412
ADH6	ENSP00000378359⁴	STRING: ENSP00000378359

About this table

Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006805	xenobiotic metabolic process	TAS	--
GO:0008202	steroid metabolic process	IMP	18356043
GO:0017144	drug metabolic process	IMP	18356043
GO:0042180	cellular ketone metabolic process	IDA	19651758
GO:0042738	exogenous drug catabolic process	IDA	19029318

CYP2B6 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CYP2B6 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CYP2B6

10/52 HMDB Compounds for CYP2B6 (see all 52) About this table

Compound	Synonyms	CAS #	PubMed Ids
10-HETE	10-hydroxyeicosa-all-cis-5,8,11,14-tetraenoate (see all 2)	167697-52-1	--
11,12,15-THETA	11,12,15-Trihydroxyicosatrienoic acid (see all 5)	--	--
11,12-Epoxyeicosatrienoic acid	10-(3-(2-octenyl)oxiranyl)-5,8-Decadienoic acid (see all 15)	81276-02-0	--
11,14,15-THETA	(5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoic acid (see all 8)	--	--
11H-14,15-EETA	14,15-Ep-11-HETrE (see all 11)	219535-29-2	--
11beta-Hydroxytestosterone	11beta,17beta-dihydroxyandrost-4-en-3-one	1816-85-9	--
12,13-EpOME	Vernolic acid (see all 12)	--	--
13-HETE	13-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoate (see all 2)	151910-72-4	--
14,15-Epoxy-5,8,11-eicosatrienoic acid	(5Z,8Z,11Z)-14,15-Epoxyicosa-5.8.11-trienoic acid (see all 11)	81276-03-1	--
15(S)-HPETE	(5Z,8Z,11Z,13E)-(15S)-15-Hydroperoxyicosa-5,8,11,13-tetraenoate (see all 8)	70981-96-3	--

10/118 DrugBank Compounds for CYP2B6 (see all 118) About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Bupropion	Amfebutamone (see all 2)	34841-39-9	enzyme	substrate inhibitor	10997936 11996013 17101742 16368442 19934256 17009913
Orphenadrine	Mephenamine (see all 7)	83-98-7	enzyme	inhibitor inducer	12813002 8242617 8789153 12712632 12515593
Selegiline	L-Deprenalin (see all 4)	14611-51-9	enzyme	substrate	19300583 18311418 17101742 17495414 19934256
Efavirenz	--	154598-52-4	enzyme	substrate inhibitor inducer	17101742 19934256 11159797 19515014
Ifosfamide	Asta Z 4942 (see all 10)	3778-73-2	enzyme	substrate	16702183 15919850 19515014 10348794
Tamoxifen	Tamoxifen Citrate (see all 5)	10540-29-1	enzyme	substrate inhibitor	12124303 15159443 19934256 19515014
4-(4-Chlorophenyl)Imidazole	--	--	target	--	17139284 17016423 10592235
Clopidogrel	--	113665-84-2	enzyme	substrate inhibitor	17101742 19934256 19515014
Cyclophosphamide	--	6055-19-2	enzyme	substrate inducer	19934256 19515014 12136253
Diazepam	--	439-14-5	enzyme	substrate	11259318 19934256 19515014

10/145 Novoseek chemical compound relationships for CYP2B6 gene (see all 145) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
androstane	93.9	45	12485946 (2), 16513849 (2), 18332083 (2), 12571232 (2) (see all 37)
citco	91.3	7	18332083 (1), 17585873 (1), 14683479 (1), 19202563 (1)
7-ethoxy-4-trifluoromethylcoumarin	90.9	22	9241656 (4), 12490624 (3), 9280407 (2), 12642465 (2) (see all 9)
hydroxybupropion	89.5	2	14515060 (2)
efavirenz	83.5	116	17559344 (9), 12676886 (7), 17918089 (5), 19659438 (5) (see all 31)
bupropion	81.2	73	14515060 (6), 18219560 (5), 10997944 (5), 18287571 (4) (see all 29)
(s)-bupropion	81	1	18219560 (1), 18287571 (1)
troleandomycin	80.4	6	18292673 (1), 15371986 (1), 14977870 (1), 16679385 (1) (see all 6)
phenobarbital	80.1	88	15572372 (6), 11093784 (3), 14977870 (3), 19920082 (3) (see all 42)
nirvanol	77.7	3	9698292 (2), 9241656 (1)

4 PharmGKB related drug/compound annotations for CYP2B6 gene

Drug/compound	PharmGKB Annotation
cyclophosphamide	CA
doxorubicin	CA
efavirenz	CA
nevirapine	CA

About this table

Search CenterWatch for drugs/clinical trials and news about CYP2B6 / CP2B6

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CYP2B6 gene:

NM_000767.4

Unigene Cluster for CYP2B6:

Cytochrome P450, family 2, subfamily B, polypeptide 6

Hs.1360 [show with all ESTs]

Unigene Representative Sequence: NM_000767

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000324071(uc002opr.1 uc010xvu.1) ENST00000330446

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		SwitchGear 3'UTR luciferase reporter plasmid: CYP2B6 3' UTR sequence

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Additional cDNA sequence:

AF182277.1 AK301620.1 BC067430.1 BC067431.1 M29874.1 X06399.1 X06400.1 X13494.1

6 DOTS entries:

DT.101982026 DT.92430531 DT.101974577 DT.121503332 DT.100766435 DT.87046467

24/44 AceView cDNA sequences (see all 44):

CF271960 T68351 NM_000767 X13494 BC067431 AF182277 BV202729 X06399

BX111410 BV202727 BV202730 CF271962 CK130229 CK130228 CK130231 T50727

T67421 CF271958 M29874 BV202726 BC067430 BV202728 BV202731 CK130230

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CYP2B6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCTGTTGTAG

About this image

CYP2B6 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

3 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Liver

Liver Lobule

Mature Hepatocytes

Liver

Adipose

Interscapular Brown Adipose Depot

Adipose

Thoracic Perivascular Adipose

Adipose

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 3 LifeMap Cells

Name

Category

Line H9 (WA09) (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

Immature hepatocytes (Functional, immature...)

Mesenchymal Progenitor Cells - Passage 2 (Differentiation of ...)

See CYP2B6 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CYP2B6

SOURCE GeneReport for Unigene cluster: Hs.1360

UniProtKB/Swiss-Prot: CP2B6_HUMAN, P20813

Tissue specificity: Expressed in liver, lung and heart right ventricle

SABiosciences Expression via Pathway-Focused PCR Arrays including CYP2B6:

Cancer Drug Resistance in human mouse rat

Drug Metabolism: Phase I Enzymes in human mouse rat

Molecular Toxicology PathwayFinder 384HT in human mouse rat

Drug Metabolism in human mouse rat

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CYP2B6 gene from 2/10 species (see all 10) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	-- -- (see all 13)	--	53(a) 53(a) (see all 13)	many ↔ many many ↔ many (see all 13)	GL343830.1(3882-12418) LGf(3241416-3252686)
zebrafish (Danio rerio)	Actinopterygii	AB026158.1²	--	75.46(n)		AB026158.1

ENSEMBL Gene Tree for CYP2B6 (if available)
TreeFam Gene Tree for CYP2B6 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CYP2B6 gene

CYP2W1² CYP2C8² CYP2F1² CYP2A7² CYP2R1² CYP2U1² CYP2J2² CYP2E1²

CYP2D6² CYP2B7P1² CYP2A6² CYP2C19² CYP2S1² CYP2C9² CYP2C18² CYP2A13²

18/28 SIMAP similar genes for CYP2B6 using alignment to 8 protein entries: CP2B6_HUMAN (see all proteins) (see all similar genes):

CYP2B7 CYP2G1P CYP2B CYP2C9 CYP 2C CYP2A13

CYP2E1 CYP2C8 CYP2A6 CYP2S1 CYP2A6V2 CYP2C18

CYP2A7 CYP2F1 CYP2J2 CYP2C19 CYP2U1 CYP2D6

CYP2B6 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

UniProtKB/Swiss-Prot: CP2B6_HUMAN, P20813

Polymorphism: Genetic variations in CYP2B6 are responsible for poor metabolism of efavirenz and, therefore,

susceptibility to efavirenz toxicity in the central nervous system [MIM:614546]. Efavirenz is a non-nucleoside reverse

transcriptase inhibitor frequently prescribed with 2 nucleoside reverse transcriptase inhibitors as initial therapy

for human immunodeficiency virus (HIV) infection. Up to half of patients treated with efavirenz, experience side

effects in the central nervous system, including dizziness, insomnia, impaired concentration, somnolence, and abnormal

dreams. Severe depression, aggressive behavior, and paranoid or manic reactions may also occur, depending on efavirenz

concentration in the plasma

SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Pop	Total sample
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs1962261^1,2	C,F,H,	--	37927247(-)	`ATACAG/ATGGGT`	1	--	us2k¹		25	NS EA NA MN WA	3736
rs12721652^1,2	C,F,H,	--	37927641(+)	`TCAGGC/TGTAGG`	1	--	us2k¹		33	NA MN NS EA WA CSA	4005
rs111930595^1,2	C,	--	37927730(+)	`AAGGTG/ACACAG`	1	--	us2k¹		1	NA	2
rs12721648^1,2	C,H	--	37927995(+)	`TGACCA/GCCTCT`	1	--	us2k¹		6	NS EA	944
rs12721653^1,2	C,F,	--	37928461(+)	`CATCAT/CGCCCG`	1	--	us2k¹		3	WA CSA	6
rs75286757^1,2		--	37928762(+)	`GCCAGT/CACATT`	1	--	us2k¹		1	NA	120
rs28723610^1,2	C,F,	--	37928832(+)	`AGCAGG/ACATGG`	1	--	us2k¹		6	NS WA	304
rs34223104^1,2	C,F,	--	37929136(+)	`AATTTT/CATAAC`	1	--	us2k¹		6	NS WA	304
rs34477445^1,2	C,F	--	37929263(+)	`GACTCT/CTGCTA`	2	/L	syn¹		2	NA	4712
rs33973337^1,2	C,F,	--	37929293(+)	`CTAACA/TCCCAT`	2	T S	mis¹		10	NA NS CSA	4888

HapMap Linkage Disequilibrium report for CYP2B6 (41497204 - 41524301 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 11 variations for CYP2B6
11 CNVs: 53651 102842 38382 4081 50145 3191 67547 89241 89240 30076 50144
Human Gene Mutation Database (HGMD): CYP2B6

Locus Specific Mutation Databases (LSDB): CYP2B6

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CYP2B6

DNA2.0 Custom Variant and Variant Library Synthesis for CYP2B6

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CYP2B6 for disorders           About GeneDecksing

OMIM gene information: 123930    OMIM disorders: --

20/56 diseases for CYP2B6 (see all 56):    About MalaCards

antley-bixler syndrome human immunodeficiency virus infectious disease graft versus host disease cholesterol

substance abuse amyotrophic lateral sclerosis toxic encephalopathy lateral sclerosis

fatty liver disease systemic lupus erythematosus lupus erythematosus chronic lymphocytic leukemia

lupus nephritis fascioliasis neutropenia lymphocytic leukemia

parkinson's disease nephritis liver disease porphyria

3 diseases from the University of Copenhagen DISEASES database for CYP2B6:

Acute frontal sinusitis Liver disease Hepatocellular carcinoma

10/21 Novoseek disease relationships for CYP2B6 gene (see all 21) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
chemical carcinogenesis	27.9	1	1720447 (1)
immunodeficiency	12.7	3	19531981 (1), 17918089 (1), 19433561 (1)
hypertrophy	5.6	3	18243468 (1), 19363144 (1), 2400826 (1)
tumors	4.12	24	12872138 (4), 12460909 (2), 9766669 (2), 19666990 (2) (see all 13)
carcinoma	3.25	1	9506744 (1)
virus infection	2.58	2	9249253 (2)
stroke	1.97	1	18332082 (1)
metastasis	0.619	2	15897573 (1)
leukemia	0	1	11090860 (1)
necrosis	0	2	17576808 (1), 1720447 (1), 18206661 (1)

Genetic Association Database (GAD): CYP2B6
Human Genome Epidemiology (HuGE) Navigator: CYP2B6 (133 documents)

Export disorders for CYP2B6 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CYP2B6 gene, integrated from 9 sources (see all 650):
(articles sorted by number of sources associating them with CYP2B6)

Utopia: connect your pdf to the dynamic
world of online information

Pharmacogenetics of efavirenz and central nervous system side effects: an Adult AIDS Clinical Trials Group study. (PubMed id 15622315)^{1, 2, 4, 9} Haas D.W....Acosta E.P. (2004)
Regulation of CYP2B6 in primary human hepatocytes by prototypical inducers. (PubMed id 14977870)^{1, 7, 9} Faucette S.R....LeCluyse E.L. (2004)
Bupropion and 4-OH-bupropion pharmacokinetics in relation to genetic polymorphisms in CYP2B6. (PubMed id 14515060)^{1, 4, 9} Kirchheiner J....Brockmoller J. (2003)
Smoking, alcoholism and genetic polymorphisms alter CYP2B6 levels in human brain. (PubMed id 12814665)^{1, 4, 9} Miksys S....Tyndale R.F. (2003)
Functional characterization of cytochrome P450 2B6 allelic variants. (PubMed id 12642465)^{1, 2, 9} Jinno H.... Ando M. (2003)
Identification of CYP2B6 sequence variants by use of multiplex PCR with allele-specific genotyping. (PubMed id 15178651)^{1, 4, 9} Jacob R.M....Walton R.T. (2004)
Pharmacogenetics of plasma efavirenz exposure after treatment discontinuation: an Adult AIDS Clinical Trials Group Study. (PubMed id 16392089)^{1, 4, 9} Ribaudo H.J....Acosta E.P. (2006)
Influence of CYP2B6 polymorphism on plasma and intracellular concentrations and toxicity of efavirenz and nevirapine in HIV-infected patients. (PubMed id 15864119)^{1, 4, 9} Rotger M....Telenti A. (2005)
Homozygous CYP2B6 *6 (Q172H and K262R) correlates with high plasma efavirenz concentrations in HIV-1 patients treated with standard efavirenz-containing regimens. (PubMed id 15194512)^{1, 4, 9} Tsuchiya K....Oka S. (2004)
Haplotype structure and allele frequencies of CYP2B6 in a Korean population. (PubMed id 15383491)^{1, 4, 9} Cho J.Y....Jang I.J. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 1555	HGNC: 2615	AceView: CYP2B6	Ensembl:ENSG00000197408	euGenes: HUgn1555
ECgene: CYP2B6	Kegg: 1555	H-InvDB: CYP2B6

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CYP2B6	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for CYP2B6	Genetics and Cytogenetics in Oncology and Haematology
Cytochrome P450 Allele Nomenclature Committee	http://www.cypalleles.ki.se/cyp2b6.htm
NIEHS-SNPs	http://egp.gs.washington.edu/data/cyp2b6/

Intellectual Property for CYP2B6 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for CYP2B6 gene:
Search GeneIP for patents involving CYP2B6

GeneCards and IP:
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CYP2B6 Gene

cytochrome P450, family 2, subfamily B, polypeptide 6

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CYP2B6 Gene

cytochrome P450, family 2, subfamily B, polypeptide 6

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