Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CYP2B6 Gene

Aliases for CYP2B6 Gene

  • Cytochrome P450, Family 2, Subfamily B, Polypeptide 6 2 3
  • Cytochrome P450, Subfamily IIB (Phenobarbital-Inducible), Polypeptide 6 2 3
  • 1,4-Cineole 2-Exo-Monooxygenase 3 4
  • Cytochrome P450 IIB1 3 4
  • CYPIIB6 3 4
  • CYP2B 3 6
  • EFVM 3 6
  • Cytochrome P450, Subfamily IIB (Phenobarbital-Inducible) 2
  • Cytochrome P450, Family 2, Subfamily B 2
  • Cytochrome P450 2B6 3
  • EC 1.14.14.1 63
  • EC 1.14.13.- 4
  • CYP2B7P 3
  • CYP2B7 3
  • CPB6 3
  • IIB1 3
  • P450 3

External Ids for CYP2B6 Gene

Previous HGNC Symbols for CYP2B6 Gene

  • CYP2B

Previous GeneCards Identifiers for CYP2B6 Gene

  • GC19P042136
  • GC19P041888
  • GC19P046107
  • GC19P046123
  • GC19P046127
  • GC19P046189
  • GC19P041497
  • GC19P037929

Summaries for CYP2B6 Gene

Entrez Gene Summary for CYP2B6 Gene

  • This gene, CYP2B6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize some xenobiotics, such as the anti-cancer drugs cyclophosphamide and ifosphamide. Transcript variants for this gene have been described; however, it has not been resolved whether these transcripts are in fact produced by this gene or by a closely related pseudogene, CYP2B7. Both the gene and the pseudogene are located in the middle of a CYP2A pseudogene found in a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. [provided by RefSeq, Jul 2008]

GeneCards Summary for CYP2B6 Gene

CYP2B6 (Cytochrome P450, Family 2, Subfamily B, Polypeptide 6) is a Protein Coding gene. Diseases associated with CYP2B6 include efavirenz, poor metabolism of and efavirenz toxicity. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include electron carrier activity and heme binding. An important paralog of this gene is CYP2C19.

UniProtKB/Swiss-Prot for CYP2B6 Gene

  • Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,4-cineole 2-exo-monooxygenase.

Gene Wiki entry for CYP2B6 Gene

PharmGKB "VIP" Summary for CYP2B6 Gene

No data available for Tocris Summary , fRNAdb sequence ontologies and piRNA Summary for CYP2B6 Gene

Genomics for CYP2B6 Gene

Regulatory Elements for CYP2B6 Gene

Genomic Location for CYP2B6 Gene

Start:
40,991,243 bp from pter
End:
41,018,398 bp from pter
Size:
27,156 bases
Orientation:
Plus strand

Genomic View for CYP2B6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CYP2B6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYP2B6 Gene

Proteins for CYP2B6 Gene

  • Protein details for CYP2B6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P20813-CP2B6_HUMAN
    Recommended name:
    Cytochrome P450 2B6
    Protein Accession:
    P20813
    Secondary Accessions:
    • B4DWP3
    • Q2V565
    • Q9UK46

    Protein attributes for CYP2B6 Gene

    Size:
    491 amino acids
    Molecular mass:
    56278 Da
    Cofactor:
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CYP2B6 Gene

    Alternative splice isoforms for CYP2B6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CYP2B6 Gene

Proteomics data for CYP2B6 Gene at MOPED

Post-translational modifications for CYP2B6 Gene

  • Phosphorylation is accompanied by a decrease in enzyme activity.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CYP2B6 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for CYP2B6 Gene

Gene Families for CYP2B6 Gene

HGNC:
  • CYP :Cytochrome P450s
IUPHAR :

Graphical View of Domain Structure for InterPro Entry

P20813

UniProtKB/Swiss-Prot:

CP2B6_HUMAN :
  • P20813
Family:
  • Belongs to the cytochrome P450 family.
genes like me logo Genes that share domains with CYP2B6: view

Function for CYP2B6 Gene

Molecular function for CYP2B6 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=360 uM for 1,4-cineole {ECO:0000269 PubMed:11695850}; Vmax=3.4 nmol/min/nmol enzyme toward 2-exo-hydroxy-1,4-cineole {ECO:0000269 PubMed:11695850};
UniProtKB/Swiss-Prot CatalyticActivity: 1,4-cineole + NADPH + O(2) = 2-exo-hydroxy-1,4-cineole + NADP(+) + H(2)O.
UniProtKB/Swiss-Prot Function: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,4-cineole 2-exo-monooxygenase.
UniProtKB/Swiss-Prot Induction: By phenobarbital

Enzyme Numbers (IUBMB) for CYP2B6 Gene

Gene Ontology (GO) - Molecular Function for CYP2B6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004497 monooxygenase activity IDA 19651758
GO:0005506 iron ion binding IEA --
GO:0008392 arachidonic acid epoxygenase activity IBA --
GO:0008395 steroid hydroxylase activity IBA --
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen --
genes like me logo Genes that share ontologies with CYP2B6: view

Phenotypes for CYP2B6 Gene

genes like me logo Genes that share phenotypes with CYP2B6: view

miRNA for CYP2B6 Gene

miRTarBase miRNAs that target CYP2B6

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for CYP2B6 Gene

Localization for CYP2B6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYP2B6 Gene

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CYP2B6 Gene COMPARTMENTS Subcellular localization image for CYP2B6 gene
Compartment Confidence
endoplasmic reticulum 5
mitochondrion 3
cytosol 2
extracellular 2
nucleus 2
peroxisome 2
plasma membrane 2
golgi apparatus 1
lysosome 1

Gene Ontology (GO) - Cellular Components for CYP2B6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0043231 intracellular membrane-bounded organelle IBA --
genes like me logo Genes that share ontologies with CYP2B6: view

Pathways for CYP2B6 Gene

genes like me logo Genes that share pathways with CYP2B6: view

Interacting Proteins for CYP2B6 Gene

Gene Ontology (GO) - Biological Process for CYP2B6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006805 xenobiotic metabolic process TAS --
GO:0008202 steroid metabolic process IMP 18356043
GO:0017144 drug metabolic process IMP 18356043
GO:0019373 epoxygenase P450 pathway IBA --
GO:0042180 cellular ketone metabolic process IDA 19651758
genes like me logo Genes that share ontologies with CYP2B6: view

Compounds for CYP2B6 Gene

(52) HMDB Compounds for CYP2B6 Gene

Compound Synonyms Cas Number PubMed IDs
10-HETE
  • 10-hydroxyeicosa-all-cis-5,8,11,14-tetraenoate
167697-52-1
11,12,15-THETA
  • 11,12,15-Trihydroxyicosatrienoic acid
Not Available
11,12-Epoxyeicosatrienoic acid
  • 10-(3-(2-octenyl)oxiranyl)-5,8-Decadienoic acid
81276-02-0
11,14,15-THETA
  • (5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoic acid
Not Available
11beta-Hydroxytestosterone
  • 11beta,17beta-dihydroxyandrost-4-en-3-one
1816-85-9

(124) Drugbank Compounds for CYP2B6 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
1-(biphenyl-4-ylmethyl)-1H-imidazole
target
4-(4-Chlorophenyl)Imidazole
target
Amitriptyline
  • Amitriprolidine
50-48-6 enzyme substrate
Amlodipine
  • Amlodipine Benzenesulfonate
88150-42-9 enzyme inhibitor
Amprenavir
  • AMP
161814-49-9 enzyme inhibitor

(145) Novoseek inferred chemical compound relationships for CYP2B6 Gene

Compound -log(P) Hits PubMed IDs
androstane 93.9 43
citco 91.3 4
7-ethoxy-4-trifluoromethylcoumarin 90.9 16
hydroxybupropion 89.5 2
efavirenz 83.5 79
genes like me logo Genes that share compounds with CYP2B6: view

Transcripts for CYP2B6 Gene

Unigene Clusters for CYP2B6 Gene

Cytochrome P450, family 2, subfamily B, polypeptide 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CYP2B6 Gene

No ASD Table

Relevant External Links for CYP2B6 Gene

GeneLoc Exon Structure for
CYP2B6
ECgene alternative splicing isoforms for
CYP2B6

Expression for CYP2B6 Gene

mRNA expression in normal human tissues for CYP2B6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CYP2B6 Gene

This gene is overexpressed in Liver (50.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CYP2B6 Gene

SOURCE GeneReport for Unigene cluster for CYP2B6 Gene Hs.1360

mRNA Expression by UniProt/SwissProt for CYP2B6 Gene

P20813-CP2B6_HUMAN
Tissue specificity: Expressed in liver, lung and heart right ventricle.
genes like me logo Genes that share expressions with CYP2B6: view

Orthologs for CYP2B6 Gene

This gene was present in the common ancestor of animals.

Orthologs for CYP2B6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CYP2B6 36
  • 93 (a)
OneToOne
LOC456052 35
  • 95.97 (n)
  • 92.37 (a)
cow
(Bos Taurus)
Mammalia CYP2B6 35
  • 83.21 (n)
  • 76.81 (a)
CYP2B6 36
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CYP2B6 35
  • 83.02 (n)
  • 77.38 (a)
CYP2B6 36
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cyp2b10 35
  • 79.41 (n)
  • 78.67 (a)
Cyp2b10 16
Cyp2b10 36
  • 78 (a)
OneToMany
Cyp2b13 36
  • 71 (a)
OneToMany
Cyp2b19 36
  • 75 (a)
OneToMany
Cyp2b23 36
  • 75 (a)
OneToMany
Cyp2b9 36
  • 72 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 61 (a)
OneToMany
-- 36
  • 70 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Cyp2b1 35
  • 79.03 (n)
  • 75.85 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 46 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Cyp304a1 37
  • 29 (a)
Cyp305a1 37
  • 29 (a)
Cyp18a1 37
  • 32 (a)
Cyp303a1 37
  • 31 (a)
worm
(Caenorhabditis elegans)
Secernentea F14H3.10 37
  • 29 (a)
B0213.12 37
  • 32 (a)
C41G6.1 37
  • 32 (a)
F41B5.2 37
  • 31 (a)
T10H4.11 37
  • 31 (a)
Y5H2B.6 37
  • 31 (a)
C45H4.2 37
  • 33 (a)
Y49C4A.9 37
  • 32 (a)
B0213.16 37
  • 30 (a)
B0213.10 37
  • 30 (a)
C50H11.15 37
  • 34 (a)
B0213.14 37
  • 31 (a)
K07C6.2 37
  • 28 (a)
K09D9.2 37
  • 29 (a)
C12D5.7 37
  • 33 (a)
K07C6.5 37
  • 29 (a)
F44C8.1 37
  • 32 (a)
K05D4.4 37
  • 31 (a)
C49G7.8 37
  • 30 (a)
B0304.3 37
  • 32 (a)
B0213.15 37
  • 30 (a)
C03G6.15 37
  • 29 (a)
F41B5.4 37
  • 33 (a)
R08F11.3 37
  • 33 (a)
B0213.11 37
  • 30 (a)
T09H2.1 37
  • 29 (a)
C45H4.17 37
  • 33 (a)
K07C6.3 37
  • 30 (a)
T10H4.10 37
  • 30 (a)
Species with no ortholog for CYP2B6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for CYP2B6 Gene

ENSEMBL:
Gene Tree for CYP2B6 (if available)
TreeFam:
Gene Tree for CYP2B6 (if available)

Paralogs for CYP2B6 Gene

genes like me logo Genes that share paralogs with CYP2B6: view

Variants for CYP2B6 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for CYP2B6 Gene

P20813-CP2B6_HUMAN
Genetic variations in CYP2B6 are responsible for poor metabolism of efavirenz and, therefore, susceptibility to efavirenz toxicity in the central nervous system [MIM:614546]. Efavirenz is a non-nucleoside reverse transcriptase inhibitor frequently prescribed with 2 nucleoside reverse transcriptase inhibitors as initial therapy for human immunodeficiency virus (HIV) infection. Up to half of patients treated with efavirenz, experience side effects in the central nervous system, including dizziness, insomnia, impaired concentration, somnolence, and abnormal dreams. Severe depression, aggressive behavior, and paranoid or manic reactions may also occur, depending on efavirenz concentration in the plasma

Sequence variations from dbSNP and Humsavar for CYP2B6 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs707265 -- 41,018,182(+) GGTTC(A/G)TGCCT utr-variant-3-prime
rs1038376 -- 41,018,104(+) GTTCC(A/T)AAGTG utr-variant-3-prime
rs1042389 -- 41,018,248(+) GCCTC(C/T)TCCTA utr-variant-3-prime
rs1872121 -- 41,004,757(+) GCTCA(A/G)GCAGG intron-variant
rs1872122 -- 40,992,092(+) agcta(C/T)ccagg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CYP2B6 Gene

Variant ID Type Subtype PubMed ID
dgv1084e1 CNV Complex 17122850
esv2718571 CNV Deletion 23290073
dgv55n17 CNV Loss 16327808
nsv523686 CNV Gain 19592680
dgv1085e1 CNV Complex 17122850
nsv517597 CNV Loss 19592680
nsv509743 CNV Insertion 20534489
esv2718572 CNV Deletion 23290073
dgv3879n71 CNV Gain 21882294
esv2597443 CNV Loss 19546169
nsv433319 CNV Loss 18776910
nsv470141 CNV Loss 18288195
dgv408n27 CNV Loss 19166990
nsv442461 CNV CNV 18776908
esv2658055 CNV Deletion 23128226
nsv470142 CNV Gain 18288195
esv24009 CNV Gain 19812545

Relevant External Links for CYP2B6 Gene

HapMap Linkage Disequilibrium report
CYP2B6
Human Gene Mutation Database (HGMD)
CYP2B6
Locus Specific Mutation Databases (LSDB)
CYP2B6
The Human Cytochrome P450 Allele Nomenclature Database
CYP2B6

Disorders for CYP2B6 Gene

(1) OMIM Diseases for CYP2B6 Gene (123930)

(2) University of Copenhagen DISEASES for CYP2B6 Gene

(21) Novoseek inferred disease relationships for CYP2B6 Gene

Disease -log(P) Hits PubMed IDs
chemical carcinogenesis 27.9 1
immunodeficiency 12.7 3
hypertrophy 5.6 3
tumors 4.12 20
carcinoma 3.25 1

Relevant External Links for CYP2B6

Genetic Association Database (GAD)
CYP2B6
Human Genome Epidemiology (HuGE) Navigator
CYP2B6
genes like me logo Genes that share disorders with CYP2B6: view

No data available for UniProtKB/Swiss-Prot for CYP2B6 Gene

Publications for CYP2B6 Gene

  1. Pharmacogenetics of efavirenz and central nervous system side effects: an Adult AIDS Clinical Trials Group study. (PMID: 15622315) Haas D.W. … Acosta E.P. (AIDS 2004) 3 4 23 48
  2. Influence of CYP2B6 polymorphism on plasma and intracellular concentrations and toxicity of efavirenz and nevirapine in HIV-infected patients. (PMID: 15864119) Rotger M. … Telenti A. (Pharmacogenet. Genomics 2005) 3 23 48
  3. Bupropion and 4-OH-bupropion pharmacokinetics in relation to genetic polymorphisms in CYP2B6. (PMID: 14515060) Kirchheiner J. … BrockmAPller J. (Pharmacogenetics 2003) 3 23 48
  4. Pharmacogenetics of plasma efavirenz exposure after treatment discontinuation: an Adult AIDS Clinical Trials Group Study. (PMID: 16392089) Ribaudo H.J. … Acosta E.P. (Clin. Infect. Dis. 2006) 3 23 48
  5. Role of polymorphic human CYP2B6 in cyclophosphamide bioactivation. (PMID: 12629583) Xie H.J. … Rane A. (Pharmacogenomics J. 2003) 3 23 48

Products for CYP2B6 Gene

Sources for CYP2B6 Gene

Back to Top

Content