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CYP2B6 Gene

protein-coding GIFtS: 66

GC19P046189

cytochrome P450, family 2, subfamily B, polypeptide 6
(Previous names: cytochrome P450, subfamily IIB (phenobarbital-inducible), polypeptide 6 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
CPB6 ^¹, ²
CYP2B ^¹, ², ⁵
CYPIIB6 ^¹, ², ³
EC 1.14.14.1 ^³
IIB1 ^²
P450 ^²

Descriptions
P450 IIB1 ^³
cytochrome P450, family 2, subfamily B, polypeptide 6 ^²
cytochrome P450, subfamily IIB (phenobarbital-inducible), polypeptide 6 ^¹, ²

External Ids
HGNC: 2615¹
Entrez Gene: 1555²
UniProtKB: P20813³
Ensembl: ENSG00000197408⁷

Search outside databases for aliases for CYP2B6 gene

Previous GC identifers: GC19P042136 GC19P041888 GC19P046107 GC19P046123 GC19P046127

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for CYP2B6:

This gene, CYP2B6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome

P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and

synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic

reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize some

xenobiotics, such as the anti-cancer drugs cyclophosphamide and ifosphamide. Transcript variants

for this gene have been described; however, it has not been resolved whether these transcripts are

in fact produced by this gene or by a closely related pseudogene, CYP2B7. Both the gene and the

pseudogene are located in the middle of a CYP2A pseudogene found in a large cluster of cytochrome

P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. [provided by RefSeq]

UniProtKB/Swiss-Prot: CP2B6_HUMAN, P20813

Function: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this

enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of

structurally unrelated compounds, including steroids, fatty acids, and xenobiotics

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the CYP2B6 gene

Entrez Gene cytogenetic band: 19q13.2 Ensembl cytogenetic band: 19q13.2 HGNC cytogenetic band: 19q13.2

CYP2B6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19P046189: (about GC identifiers)

Start:	46,189,044 bp from pter
End:	46,216,141 bp from pter
Size:	27,098 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000019.8 NT_011109.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: CP2B6_HUMAN, P20813 (See protein sequence)

Recommended Name: Cytochrome P450 2B6

Size: 491 amino acids; 56278 Da

Cofactor: Heme group (By similarity)

Subcellular location: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome

membrane; Peripheral membrane protein

Secondary accessions: Q2V565 Q9UK46

Post-translational modifications:

Phosphorylation is accompanied by a decrease in enzyme activity (By similarity)¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_000758.1

ENSEMBL proteins:

ENSP00000324648

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Sigma-Aldrich AQUA Peptides for CYP2B6
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Cytochrome P450 2B6)
	Human Recombinant Proteins from Abnova (CYP2B6)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005783	endoplasmic reticulum	NAS	--
GO:0005789	endoplasmic reticulum membrane	IEA	--
GO:0005792	microsome	NAS	--
GO:0016020	membrane	IEA	--

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Antibodies for CYP2B6:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of CYP2B6
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (Cytochrome P450 2B6), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Novus Biologicals Antibody for CYP2B6

Assays for CYP2B6:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P20813

ProtoNet protein and cluster: P20813

2 Blocks protein families:

IPB002401 E-class P450 group I signature

IPB008068 CYP2B P450 family signature

UniProtKB/Swiss-Prot: CP2B6_HUMAN, P20813

Similarity: Belongs to the cytochrome P450 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CYP2B6)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CYP2B6)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000767

Applied Biosystems Silencer® siRNAs for CYP2B6

Sigma-Aldrich siRNA and siRNA Panels for CYP2B6

Sigma-Aldrich shRNA for CYP2B6

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for CYP2B6
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_000767
Myc/DDK tagged cDNA clone in CMV expression vector: NM_000767
untagged cDNA clone in CMV expression vector: NM_000767

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000767

UniProtKB/Swiss-Prot: CP2B6_HUMAN, P20813

Function: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this

enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of

structurally unrelated compounds, including steroids, fatty acids, and xenobiotics

Catalytic activity: RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O

Induction: By phenobarbital

Enzyme Number (IUBMB): EC 1.14.14.1

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0009055	electron carrier activity	IEA	--
GO:0020037	heme binding	IEA	--
GO:0046872	metal ion binding	IEA	--
GO:0070330	aromatase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/9 Sigma-Aldrich "Your Favorite Gene" Pathways for CYP2B6 (Your Favorite Gene powered by Ingenuity) (see all 9 )

Linoleic Acid Metabolism
Inositol Metabolism
PXR/RXR Activation
Tryptophan Metabolism
Arachidonic Acid Metabolism

GeneDecks CYP2B6 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for CYP2B6

5/95 Interacting proteins for CYP2B6 (ENSP00000324648³) via UniProtKB, MINT, and/or STRING (see all 95 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
EPHX1	ENSP00000355802³	STRING (score=.973)
UGT1A1	ENSP00000362513³	STRING (score=.972)
GSTA1	ENSP00000335620³	STRING (score=.967)
GSTP1	ENSP00000196968³	STRING (score=.967)
GSTM1	ENSP00000358838³	STRING (score=.964)

About this table

1 Gene Ontology (GO) biological process term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0055114	oxidation reduction	NAS	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for CYP2B6

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for CYP2B6
10/52 Novoseek chemical compound relationships for CYP2B6 gene (see all 52 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
androstane	93.83	43	12485946 (2), 16513849 (2), 18332083 (2), 12571232 (2) (see all 35)
citco	92.35	7	18332083 (1), 17585873 (1), 14683479 (1), 19202563 (1)
7-ethoxy-4-trifluoromethylcoumarin	91.50	22	9241656 (4), 12490624 (3), 9280407 (2), 12642465 (2) (see all 9)
hydroxybupropion	89.63	2	14515060 (2)
(s)-bupropion	81.61	1	18219560 (1), 18287571 (1)
ethoxyresorufin	72.76	6	9454825 (1), 12818727 (1), 19096794 (1), 9806947 (1) (see all 5)
7-ethoxycoumarin	71.57	7	8460938 (1), 7720526 (1), 12490624 (1), 14751731 (1) (see all 6)
2-nitroanisole	70.22	4	17159769 (1), 15144223 (1)
metofluthrin	70.22	2	19378387 (1), 19176367 (1)
aq 4n	68.51	5	15712360 (4), 10834269 (1)

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10/15 PharmGKB drug compound relationships for CYP2B6 gene (see all 15 )

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
aflatoxin b1	PD PK FA	9280407 8242617
bupropion	PD PK GN	10997944 12439223 14515060
cyclophosphamide	PD PK FA	9280407 8242617
dexamethasone	PK FA	8114683
efavirenz	PK GN	15622315
etoposide	PK FA	8114683
ifosfamide	PD PK FA	8242617 9280407
midazolam	PK FA	8114683
phenobarbital	PK	9157990
propofol	PK FA	11298076

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CYP2B6)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CYP2B6)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000767

Sigma-Aldrich siRNA and siRNA Panels for CYP2B6

Sigma-Aldrich shRNA for CYP2B6

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000767

REFSEQ mRNAs for CYP2B6 gene:

NM_000767.4

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000767

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000767
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000767
                                 untagged cDNA clone in CMV expression vector: NM_000767

Additional cDNA sequence:

AF182277.1 AK301620.1 BC067430.1 BC067431.1 M29874.1 X06399.1 X06400.1 X13494.1

5 DOTS entries:

DT.101982026 DT.101974577 DT.92430531 DT.121503332 DT.87046467

24/44 AceView cDNA sequences (see all 44 ):

NM_000767 T68351 CF271960 BV202728 T50727 CF271962 T67421 CK130228

CK130231 CK130230 M29874 BV202727 AF182277 BV202731 BV202726 BC067430

BX111410 CK130229 BV202730 BV202729 X13494 X06399 CF271958 BC067431

highest scoring ESTs for CYP2B6:

M29874 AF182277 BC067430 BC067431 CF271958 CF271959 CK032855 CK032856 CK032857 CK032858

Unigene Cluster for CYP2B6:

Cytochrome P450, family 2, subfamily B, polypeptide 6

Hs.1360 [show with all ESTs]

Unigene Representative Sequence: NM_000767

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000324071

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

CYP2B6 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for CYP2B6

¹ / ² / ³

7 probe-sets matching CYP2B6 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
1371_s_at²^{, 3}	U95-A	2	1.00	0.50	1.00	1.00	M29874	1.00	0.90	0.95	1
206755_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000767	0.60	1.00	0.82	1
217133_x_at²^{, 3}	U133-A	2	1.00	0.68	--	--	X06399	0.60	1.00	0.82	1
206754_s_at²^{, 3}	U133-A	2	1.00	0.50	--	--	NM_000767	0.60	1.00	0.82	1
206755_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
217133_x_at²	U133Plus2	2	1.00	0.68	--	--	--	--	--	--	--
206754_s_at²	U133Plus2	2	1.00	0.50	--	--	--	--	--	--	--

GeneDecks CYP2B6 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CCTGTTGTAG

SOURCE GeneReport for Unigene cluster: Hs.1360
Expression variation in blood from EXPOLDB for CYP2B6
UniProtKB/Swiss-Prot: CP2B6_HUMAN, P20813
Tissue specificity: Expressed in liver, lung and heart right ventricle

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for CYP2B6 gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	CYPIIB11¹	--	cytochrome P450 2B11	83.1(n) 78(a)	474177 XM_850512.1 XP_855605.1
cow (Bos taurus)	CYP2B¹	--	cytochrome P450 subfamily 2B	82.69(n) 76.31(a)	504769 NM_001075173.1 NP_001068641.1
rat (Rattus norvegicus)	Cyp2b2¹	--	cytochrome P450, family 2, subfamily b, polypeptide more	78.82(n) 74.95(a)	361523 XM_001062335.1 XP_001062335.1
mouse (Mus musculus)	Cyp2b10¹	--	cytochrome P450, family 2, subfamily b, polypeptide more	78.14(n) 75.76(a)	13088 NM_009998.4 NP_034128.1
zebrafish (Danio rerio)	AB026158.1²	--	--	75.46(n)	AB026158.1

About this table Species with no ortholog for CYP2B6

ENSEMBL Gene Tree for CYP2B6

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for CYP2B6 gene

CYP2S1² CYP2B7P1² CYP2A6² CYP2A13² CYP2A7²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/362 NCBI SNPs in CYP2B6 are shown (see all 362 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 93)

AB	SNP ID	Valid	Chr 19 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs2054675^1,2	A,C,F,H,O	46187595(+)	`TCCAGT/CAGACA`	1	--	ng5¹ tfbs³		8		NA EA MN EU WA	761
--	rs1042389^1,2	C,F,H,O	46215993(+)	`GCCTCT/CTCCTA`	1	--	ut3¹		10		MN EU EA WA NS	792
--	rs1038376^1,2	A,C,F,H	46215849(+)	`GTTCCA/TAAGTG`	1	--	ut3¹ ese³		10		MN EU EA WA NS	786
	rs3745274^1,2	A,C,F,H	46204681(+)	`TTCCAG/TTCCAT`	1	Q/H	mis¹ ese³		9		EU EA NS	828
--	rs707265^1,2	A,C,F,H	46215927(+)	`GGTTCG/ATGCCT`	1	--	ut3¹ ese³		9		EU EA WA NS	602
--	rs4802100^1,2	C,F,H	46187865(+)	`TCTTGC/GTCCTC`	1	--	ng5¹ trp³		8		EU EA WA	840
	rs4802101^1,2	A,C,F	46188301(+)	`cccggC/Ttaatt`	1	--	ng5¹ tfbs³		0	--	--	--	--
--	rs7260525^1,2	A,C,F	46215094(+)	`TGTATA/GTATAT`	1	--	ut3¹ ese³		5		NS	190
--	rs8192709^1,2	C,F,H	46189114(+)	`TTCAGC/TGCCAC`	1	R/C	mis¹ ese³		9		EU EA WA NS	606
	rs3760657^1,2	C,F,H	46187273(+)	`AGCACA/GGCAAG`	1	--	ng5¹		4		EU EA WA	420

About this table

HapMap Linkage Disequilibrium images for CYP2B6 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 123930

10/19 Novoseek disease relationships for CYP2B6 gene (see all 19 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
chemical carcinogenesis	29.95	1	1720447 (1)
immunodeficiency	8.43	1	17918089 (1)
hypertrophy	4.04	2	18243468 (1), 2400826 (1)
carcinoma	3.63	1	9506744 (1)
virus infection	2.83	2	9249253 (2)
stroke	2.29	1	18332082 (1)
tumors	2.22	19	12872138 (4), 12460909 (2), 9766669 (2), 18212249 (2) (see all 10)
metastasis	0.67	2	15897573 (1)
necrosis	0.00	2	17576808 (1), 1720447 (1), 18206661 (1)
alcoholism	0.00	1	12814665 (1)

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2 PharmGKB disease relationships for CYP2B6 gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
HIV Infections	PK GN	15622315
nicotine addiction	PD	12439223

About this table

Human Gene Mutation Database: CYP2B6
Genetic Association Database: CYP2B6
Human Genome Epidemiology Navigator: CYP2B6 (78 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

CROI: Variant Enzyme Accounts for Different Efavirenz Clearance Times Among the Races

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/450 PubMed articles for CYP2B6 gene (see all 450 ):

Pharmacogenetics of efavirenz and central nervous system side effects: an Adult AIDS Clinical Trials Group study. (PubMed id 15622315)^{1, 3, 6, 7} Haas D.W....Acosta E.P. (2004)
Bupropion and 4-OH-bupropion pharmacokinetics in relation to genetic polymorphisms in CYP2B6. (PubMed id 14515060)^{1, 3, 6, 7} Kirchheiner J....Brockmoller J. (2003)
Hepatic CYP2B6 expression: gender and ethnic differences and relationship to CYP2B6 genotype and CAR (constitutive androstane receptor) expression. (PubMed id 14551287)^{1, 4, 7} Lamba V.... Schuetz E.G. (2003)
Pharmacogenetic investigation of smoking cessation treatment. (PubMed id 12439223)^{3, 6, 7} Lerman C....Epstein L. (2002)
Smoking, alcoholism and genetic polymorphisms alter CYP2B6 levels in human brain. (PubMed id 12814665)^{1, 3, 6} Miksys S....Tyndale R.F. (2003)
Functional characterization of cytochrome P450 2B6 allelic variants. (PubMed id 12642465)^{1, 3, 4} Jinno H.... Ando M. (2003)
Identification of CYP2B6 sequence variants by use of multiplex PCR with allele-specific genotyping. (PubMed id 15178651)^{1, 3, 6} Jacob R.M....Walton R.T. (2004)
Influence of CYP2B6 polymorphism on plasma and intracellular concentrations and toxicity of efavirenz and nevirapine in HIV-infected patients. (PubMed id 15864119)^{1, 3, 6} Rotger M....Telenti A. (2005)
Homozygous CYP2B6 *6 (Q172H and K262R) correlates with high plasma efavirenz concentrations in HIV-1 patients treated with standard efavirenz-containing regimens. (PubMed id 15194512)^{1, 3, 6} Tsuchiya K....Oka S. (2004)
Haplotype structure and allele frequencies of CYP2B6 in a Korean population. (PubMed id 15383491)^{1, 3, 6} Cho J.Y....Jang I.J. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 1555	HGNC: 2615	AceView: CYP2B6	Ensembl:ENSG00000197408	euGenes: HUgn1555
ECgene: CYP2B6	H-InvDB: CYP2B6

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for CYP2B6	Genetics and Cytogenetics in Oncology and Haematology
Cytochrome P450 Allele Nomenclature Committee	http://www.cypalleles.ki.se/cyp2b6.htm
NIEHS-SNPs	http://egp.gs.washington.edu/data/cyp2b6/

Licensable Technologies for CYP2B6
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for CYP2B6:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for CYP2B6-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for CYP2B6		Browse antibodies at Sigma-Aldrich
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Antibodies for CYP2B6

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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CYP2B6 Gene at Home site.
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CYP2B6 Gene

protein-coding GIFtS: 66

Aliases &
Descriptions
for CYP2B6

Summaries
for CYP2B6

Genomic Location
for CYP2B6

Proteins
for CYP2B6

Protein Domains/
Families
for CYP2B6

Gene Function
for CYP2B6

Pathways & Interactions
for CYP2B6

Drugs & Compounds
for CYP2B6

Transcripts
for CYP2B6

Expression
for CYP2B6

Orthologs
for CYP2B6

Paralogs
for CYP2B6

SNPs/Variants
for CYP2B6

Disorders & Mutations
for CYP2B6

Medical News
for CYP2B6

Publications
for CYP2B6

Search for CYP2B6

Genome Databases showing CYP2B6

Other Databases showing CYP2B6

Specialized Databases showing CYP2B6

Licensable Technologies
for CYP2B6

Services
for CYP2B6

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

CYP2B6 Gene

protein-coding GIFtS: 66

Aliases & Descriptionsfor CYP2B6

Summariesfor CYP2B6

Genomic Locationfor CYP2B6

Proteinsfor CYP2B6

Protein Domains/Familiesfor CYP2B6

Gene Functionfor CYP2B6

Pathways & Interactionsfor CYP2B6

Drugs & Compoundsfor CYP2B6

Transcriptsfor CYP2B6

Expression for CYP2B6

Orthologsfor CYP2B6

Paralogsfor CYP2B6

SNPs/Variantsfor CYP2B6

Disorders & Mutationsfor CYP2B6

Medical Newsfor CYP2B6

Publicationsfor CYP2B6

Search for CYP2B6

Genome Databases showing CYP2B6

Other Databases showing CYP2B6

Specialized Databases showing CYP2B6

Licensable Technologiesfor CYP2B6

Servicesfor CYP2B6

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for CYP2B6

Summaries
for CYP2B6

Genomic Location
for CYP2B6

Proteins
for CYP2B6

Protein Domains/
Families
for CYP2B6

Gene Function
for CYP2B6

Pathways & Interactions
for CYP2B6

Drugs & Compounds
for CYP2B6

Transcripts
for CYP2B6

Expression
for CYP2B6

Orthologs
for CYP2B6

Paralogs
for CYP2B6

SNPs/Variants
for CYP2B6

Disorders & Mutations
for CYP2B6

Medical News
for CYP2B6

Publications
for CYP2B6

Licensable Technologies
for CYP2B6

Services
for CYP2B6