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CYP2B6 Gene

protein-coding   GIFtS: 69
GCID: GC19P041497

Cytochrome P450, Family 2, Subfamily B, Polypeptide 6

(Previous names: cytochrome P450, subfamily IIB (phenobarbital-inducible),...)
(Previous symbol: CYP2B)
  See CYP2B6-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cytochrome P450, Family 2, Subfamily B, Polypeptide 61 2     CPB62
CYP2B1 2 5     CYP2B72
Cytochrome P450, Subfamily IIB (Phenobarbital-Inducible), Polypeptide 61 2     CYP2B7P2
Cytochrome P450 IIB12 3     IIB12
1,4-Cineole 2-Exo-Monooxygenase2 3     P4502
CYPIIB62 3     Cytochrome P450 2B62
EFVM2 5     EC 1.14.13.-3
Cytochrome P450, Family 2, Subfamily B1     EC 1.14.14.18
Cytochrome P450, Subfamily IIB (Phenobarbital-Inducible)1     

External Ids:    HGNC: 26151   Entrez Gene: 15552   Ensembl: ENSG000001974087   OMIM: 1239305   UniProtKB: P208133   

Export aliases for CYP2B6 gene to outside databases

Previous GC identifers: GC19P042136 GC19P041888 GC19P046107 GC19P046123 GC19P046127 GC19P046189 GC19P037929


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CYP2B6 Gene:
This gene, CYP2B6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins
are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol,
steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by
phenobarbital. The enzyme is known to metabolize some xenobiotics, such as the anti-cancer drugs cyclophosphamide
and ifosphamide. Transcript variants for this gene have been described; however, it has not been resolved whether
these transcripts are in fact produced by this gene or by a closely related pseudogene, CYP2B7. Both the gene and
the pseudogene are located in the middle of a CYP2A pseudogene found in a large cluster of cytochrome P450 genes
from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. (provided by RefSeq, Jul 2008)

GeneCards Summary for CYP2B6 Gene:
CYP2B6 (cytochrome P450, family 2, subfamily B, polypeptide 6) is a protein-coding gene. Diseases associated with CYP2B6 include acute frontal sinusitis, and efavirenz, poor metabolism of. GO annotations related to this gene include electron carrier activity and heme binding. An important paralog of this gene is CYP2W1.

UniProtKB/Swiss-Prot: CP2B6_HUMAN, P20813
Function: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is
involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated
compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,4-cineole 2-exo-monooxygenase

Gene Wiki entry for CYP2B6 Gene

PharmGKB "VIP" summary for CYP2B6


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CYP2B6 gene promoter:
         GR   TBP   NF-kappaB   c-Ets-1   TFIID   GR-alpha   MRF-2   NF-kappaB1   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CYP2B6 promoter sequence
   Search Chromatin IP Primers for CYP2B6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CYP2B6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.2   Ensembl cytogenetic band:  19q13.2   HGNC cytogenetic band: 19q13.2

CYP2B6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CYP2B6 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P041497:  view genomic region     (about GC identifiers)

Start:
41,497,204 bp from pter      End:
41,524,303 bp from pter
Size:
27,100 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CP2B6_HUMAN, P20813 (See protein sequence)
Recommended Name: Cytochrome P450 2B6  
Size: 491 amino acids; 56278 Da
Cofactor: Heme group
5 PDB 3D structures from and Proteopedia for CYP2B6:
3IBD (3D)        3QOA (3D)        3QU8 (3D)        3UA5 (3D)        4I91 (3D)    
Secondary accessions: Q2V565 Q9UK46

Explore the universe of human proteins at neXtProt for CYP2B6: NX_P20813

Explore proteomics data for CYP2B6 at MOPED

Post-translational modifications: 

  • Phosphorylation is accompanied by a decrease in enzyme activity (By similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for CYP2B6 (P20813) (see all 14)
     TTILQNF  DRAKMPY  PGPRPLP  FGMGKRS 


    See CYP2B6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000758.1  
    ENSEMBL proteins: 
     ENSP00000324648   ENSP00000470582   ENSP00000330650  
    Reactome Protein details: P20813

    CYP2B6 Human Recombinant Protein Products:

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    Novus Biologicals CYP2B6 Protein
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    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for CYP2B6

     
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    Abcam antibodies for CYP2B6
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    Search ThermoFisher Antibodies for CYP2B6
    LSBio Antibodies in human, mouse, rat for CYP2B6

    CYP2B6 Assay Products:

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    Search eBioscience for ELISAs for CYP2B6 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CYP: Cytochrome P450s

    IUPHAR Guide to PHARMACOLOGY protein family classification: CYP2B6
    CYP2 family

    4 InterPro protein domains:
     IPR008068 Cyt_P450_E_grp-I_CYP2B-like
     IPR001128 Cyt_P450
     IPR017972 Cyt_P450_CS
     IPR002401 Cyt_P450_E_grp-I

    Graphical View of Domain Structure for InterPro Entry P20813

    ProtoNet protein and cluster: P20813

    2 Blocks protein domains:
    IPB002401 E-class P450 group I signature
    IPB008068 CYP2B P450 family signature


    UniProtKB/Swiss-Prot: CP2B6_HUMAN, P20813
    Similarity: Belongs to the cytochrome P450 family


    Find genes that share domains with CYP2B6           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CP2B6_HUMAN, P20813
    Function: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is
    involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated
    compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,4-cineole 2-exo-monooxygenase
    Catalytic activity: 1,4-cineole + NADPH + O(2) = 2-exo-hydroxy-1,4-cineole + NADP(+) + H(2)O
    Biophysicochemical properties: Kinetic parameters: KM=360 uM for 1,4-cineole; Vmax=3.4 nmol/min/nmol enzyme toward
    2-exo-hydroxy-1,4-cineole;
    Induction: By phenobarbital

         Enzyme Numbers (IUBMB): EC 1.14.14.12 EC 1.14.13.-1

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004497monooxygenase activity IDA19651758
    GO:0005506iron ion binding IEA--
    GO:0016705oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen ----
    GO:0016712oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IEA--
    GO:0020037heme binding IDA--
         
    Find genes that share ontologies with CYP2B6           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for CYP2B6:
     Decreased Hepatitis C virus re  Synthetic lethal with imatinib 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CYP2B6
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CYP2B6
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CYP2B6

    miRNA
    Products:
        
    miRTarBase miRNAs that target CYP2B6:
    hsa-let-7e-5p (MIRT051706)

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    6 qRT-PCR Assays for microRNAs that regulate CYP2B6:
    hsa-miR-1266 hsa-miR-3622b-3p hsa-miR-3613-3p hsa-miR-616* hsa-miR-1827 hsa-miR-373*
    SwitchGear 3'UTR luciferase reporter plasmidCYP2B6 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat CYP2B6

    Gene Editing
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    Clone
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    OriGene clones in human, mouse for CYP2B6 (see all 6)
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    GenScript: all cDNA clones in your preferred vector: CYP2B6 (NM_000767)
    Browse Sino Biological Human cDNA Clones
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYP2B6


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CP2B6_HUMAN, P20813: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral
    membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    mitochondrion3
    cytosol2
    extracellular2
    nucleus2
    peroxisome2
    plasma membrane2
    golgi apparatus1
    lysosome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum ----
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0043231intracellular membrane-bounded organelle ----

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    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CYP2B6 About   (see all 14)  
    See pathways by source

    SuperPathContained pathways About
    1Cytochrome P450 - arranged by substrate type
    Cytochrome P450 - arranged by substrate type0.75
    Fatty acids0.00
    Phase 1 - Functionalization of compounds0.75
    Cyclophosphamide Pathway, Pharmacokinetics0.00
    cytochrome P4500.74
    Ifosfamide Pathway, Pharmacokinetics0.00
    Xenobiotics0.00
    CYP2E1 reactions0.00
    2Biological oxidations
    Biological oxidations0.56
    Tamoxifen Pathway, Pharmacokinetics0.00
    metapathway biotransformation0.42
    Sorafenib Pharmacokinetics0.00
    Phenytoin Pathway, Pharmacokinetics0.00
    3Chemical carcinogenesis
    Metabolism of xenobiotics by cytochrome P4500.71
    Retinol metabolism0.35
    Drug metabolism - cytochrome P4500.69
    Artemisinin and Derivatives Pathway, Pharmacokinetics0.00
    4Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    5Nicotine Pathway, Pharmacokinetics
    Nicotine Pathway, Pharmacokinetics
    Nicotine metabolism0.00


    Find genes that share SuperPaths with CYP2B6           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 GeneGo (Thomson Reuters) Pathways for CYP2B6
        Retinol metabolism
    2-Naphthylamine and 2-Nitronaphtalene metabolism

    5 BioSystems Pathways for CYP2B6
        cytochrome P450
    bupropion degradation
    Nuclear receptors in lipid metabolism and toxicity
    Nicotine metabolism
    metapathway biotransformation

    3 Reactome Pathways for CYP2B6
        Fatty acids
    Xenobiotics
    CYP2E1 reactions

    Selected PharmGKB Pathways for CYP2B6 (see all 12)
        Artemisinin and Derivatives Pathway, Pharmacokinetics
    Carbamazepine Pathway, Pharmacokinetics
    Clopidogrel Pathway, Pharmacokinetics
    Cyclophosphamide Pathway, Pharmacokinetics
    Ifosfamide Pathway, Pharmacokinetics

    5 Kegg Pathways  (Kegg details for CYP2B6):
        Arachidonic acid metabolism
    Retinol metabolism
    Metabolism of xenobiotics by cytochrome P450
    Drug metabolism - cytochrome P450
    Metabolic pathways

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CYP2B6: 
              Cancer Drug Resistance in human mouse rat
              Drug Metabolism: Phase I Enzymes in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat
              Drug Metabolism in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CYP2B6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CYP2B6 (ENSP000003246484) via UniProtKB, MINT, STRING, and/or I2D (see all 109)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ADH1AENSP000002096684STRING: ENSP00000209668
    ADH1BENSP000003066064STRING: ENSP00000306606
    ADH4ENSP000002655124STRING: ENSP00000265512
    ADH5ENSP000002964124STRING: ENSP00000296412
    ADH6ENSP000003783594STRING: ENSP00000378359
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006805xenobiotic metabolic process TAS--
    GO:0008202steroid metabolic process IMP18356043
    GO:0017144drug metabolic process IMP18356043
    GO:0042180cellular ketone metabolic process IDA19651758
    GO:0042738exogenous drug catabolic process IDA19029318

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    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CYP2B6 (CP2B6)

    Selected HMDB Compounds for CYP2B6 (see all 52)    About this table
    CompoundSynonyms CAS #PubMed Ids
    10-HETE10-hydroxyeicosa-all-cis-5,8,11,14-tetraenoate (see all 2)167697-52-1--
    11,12,15-THETA11,12,15-Trihydroxyicosatrienoic acid (see all 5)----
    11,12-Epoxyeicosatrienoic acid10-(3-(2-octenyl)oxiranyl)-5,8-Decadienoic acid (see all 15)81276-02-0--
    11,14,15-THETA(5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoic acid (see all 8)----
    11H-14,15-EETA14,15-Ep-11-HETrE (see all 11)219535-29-2--
    11beta-Hydroxytestosterone11beta,17beta-dihydroxyandrost-4-en-3-one 1816-85-9--
    12,13-EpOMEVernolic acid (see all 12)----
    13-HETE13-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoate (see all 2)151910-72-4--
    14,15-Epoxy-5,8,11-eicosatrienoic acid(5Z,8Z,11Z)-14,15-Epoxyicosa-5.8.11-trienoic acid (see all 11)81276-03-1--
    15(S)-HPETE(5Z,8Z,11Z,13E)-(15S)-15-Hydroperoxyicosa-5,8,11,13-tetraenoate (see all 8)70981-96-3--

    Selected DrugBank Compounds for CYP2B6 (see all 124)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    BupropionAmfebutamone (see all 2)34841-39-9enzymesubstrate inhibitor10997936 11996013 17101742 16368442 19934256 17009913
    OrphenadrineMephenamine (see all 7)83-98-7enzymeinhibitor inducer12813002 8242617 8789153 12712632 12515593
    SelegilineL-Deprenalin (see all 4)14611-51-9enzymesubstrate19300583 18311418 17101742 17495414 19934256
    Efavirenz-- 154598-52-4enzymesubstrate inhibitor inducer17101742 19934256 11159797 19515014
    Ifosfamide-- 3778-73-2enzymesubstrate16702183 15919850 19515014 10348794
    TamoxifenICI-46474 (see all 3)10540-29-1enzymesubstrate inhibitor12124303 15159443 19934256 19515014
    4-(4-Chlorophenyl)Imidazole-- --target--17139284 17016423 10592235
    Clopidogrel-- 113665-84-2enzymesubstrate inhibitor17101742 19934256 19515014
    CyclophosphamideCPM (see all 5)50-18-0enzymesubstrate inducer19934256 19515014 12136253
    Diazepam-- 439-14-5enzymesubstrate11259318 19934256 19515014

    Selected Novoseek inferred chemical compound relationships for CYP2B6 gene (see all 145)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    androstane 93.9 45 12485946 (2), 16513849 (2), 18332083 (2), 12571232 (2) (see all 37)
    citco 91.3 7 18332083 (1), 17585873 (1), 14683479 (1), 19202563 (1)
    7-ethoxy-4-trifluoromethylcoumarin 90.9 22 9241656 (4), 12490624 (3), 9280407 (2), 12642465 (2) (see all 9)
    hydroxybupropion 89.5 2 14515060 (2)
    efavirenz 83.5 116 17559344 (9), 12676886 (7), 17918089 (5), 19659438 (5) (see all 31)
    bupropion 81.2 73 14515060 (6), 18219560 (5), 10997944 (5), 18287571 (4) (see all 29)
    (s)-bupropion 81 1 18219560 (1), 18287571 (1)
    troleandomycin 80.4 6 18292673 (1), 15371986 (1), 14977870 (1), 16679385 (1) (see all 6)
    phenobarbital 80.1 88 15572372 (6), 11093784 (3), 14977870 (3), 19920082 (3) (see all 42)
    nirvanol 77.7 3 9698292 (2), 9241656 (1)

    Selected PharmGKB related drug/compound annotations for CYP2B6 gene (see all 20)    About this table
    Drug/compound PharmGKB Annotation
    clobazam
    clopidogrel  CA  
    crizotinib
    cyclophosphamideCA  
    dabrafenib
    dasatinib
    dexlansoprazole
    dextromethorphan
    doxorubicinCA  
    efavirenz  CA  



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    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CYP2B6 gene: 
    NM_000767.4  

    Unigene Cluster for CYP2B6:

    Cytochrome P450, family 2, subfamily B, polypeptide 6
    Hs.1360  [show with all ESTs]
    Unigene Representative Sequence: NM_000767
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000324071(uc002opr.1 uc010xvu.1) ENST00000598834 ENST00000593831
    ENST00000594187 ENST00000597612 ENST00000330446
    miRNA
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    Block miRNA regulation of human, mouse, rat CYP2B6 using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate CYP2B6:
    hsa-miR-1266 hsa-miR-3622b-3p hsa-miR-3613-3p hsa-miR-616* hsa-miR-1827 hsa-miR-373*
    SwitchGear 3'UTR luciferase reporter plasmidCYP2B6 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for CYP2B6
    Predesigned siRNA for gene silencing in human, mouse, rat CYP2B6
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    OriGene clones in human, mouse for CYP2B6 (see all 6)
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    GenScript: all cDNA clones in your preferred vector: CYP2B6 (NM_000767)
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    Additional mRNA sequence: 

    AF182277.1 AK301620.1 BC067430.1 BC067431.1 M29874.1 X06399.1 X06400.1 X13494.1 

    6 DOTS entries:

    DT.101982026  DT.92430531  DT.101974577  DT.121503332  DT.100766435  DT.87046467 

    Selected AceView cDNA sequences (see all 44):

    NM_000767 CF271960 T68351 X13494 BC067430 CK130231 CK130228 AF182277 
    X06399 BV202729 BV202730 T67421 BX111410 CK130229 BV202731 BV202727 
    CF271962 CF271958 BC067431 CK130230 M29874 BV202726 BV202728 T50727 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    CYP2B6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTGTTGTAG
    CYP2B6 Expression
    About this image


    CYP2B6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Liver (Hepatobiliary System)    fully expand to see all 2 entries
             Mature Hepatocytes Liver Lobule
             Immature hepatocytes
     
     Adipose (Muscoskeletal System)    fully expand to see all 2 entries
             Thoracic Perivascular Adipose
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Human embryonic stem cells (family)
     
     Heart (Cardiovascular System)
             Atrioventricular Node
     
     Hair (Integumentary System)
             Bulge Stem Cells Bulge
    CYP2B6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CYP2B6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.1360

    UniProtKB/Swiss-Prot: CP2B6_HUMAN, P20813
    Tissue specificity: Expressed in liver, lung and heart right ventricle

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CYP2B6: 
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              Drug Metabolism in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of chordates.

    Orthologs for CYP2B6 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cyp2b101 , 5 cytochrome P450, family 2, subfamily b, polypeptide more1, 5 79.41(n)1
    78.67(a)1
      7 (14.11 cM)5
    130881  NM_009999.31  NP_034129.11 
     258976205 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    46(a)
    many ↔ many
    AAWZ02034995(17357-35599)
    zebrafish
    (Danio rerio)
    Actinopterygii AB026158.12   -- 75.46(n)    AB026158.1 


    ENSEMBL Gene Tree for CYP2B6 (if available)
    TreeFam Gene Tree for CYP2B6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CYP2B6 gene
    CYP2W12  CYP2C82  CYP2A62  CYP2F12  CYP2A72  CYP2C192  CYP2R12  CYP2J22  
    CYP2U12  CYP2S12  CYP2E12  CYP2C92  CYP2D62  CYP2C182  CYP2A132  
    Selected SIMAP similar genes for CYP2B6 using alignment to 8 protein entries:     CP2B6_HUMAN (see all proteins) (see all similar genes):
    CYP2G1P    CYP2B7    CYP2B    CYP 2C    CYP2E1    CYP2S1
    CYP2F1    CYP2J2    CYP2C8    CYP2C18    CYP2C9    CYP2A13
    CYP2U1    CYP2A7    CYP2A6    DKFZp686I24235    CYP2A6V2    CYP2D6

    Find genes that share paralogs with CYP2B6           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    CP2B6_HUMAN, P20813: Genetic variations in CYP2B6 are responsible for poor metabolism of efavirenz and, therefore,
    susceptibility to efavirenz toxicity in the central nervous system [MIM:614546]. Efavirenz is a non-nucleoside
    reverse transcriptase inhibitor frequently prescribed with 2 nucleoside reverse transcriptase inhibitors as
    initial therapy for human immunodeficiency virus (HIV) infection. Up to half of patients treated with efavirenz,
    experience side effects in the central nervous system, including dizziness, insomnia, impaired concentration,
    somnolence, and abnormal dreams. Severe depression, aggressive behavior, and paranoid or manic reactions may also
    occur, depending on efavirenz concentration in the plasma


    Selected SNPs for CYP2B6 (see all 1144)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs37865491,2
    C--37953757(+) AAGGCA/GGTAAC 1 -- int10--------
    rs37865501,2
    C,A--37953758(+) AGGCAA/GTAACC 1 -- int10--------
    rs32113991,2
    F--37956196(+) TACTGC/TTTCCG 1 -- ut31 ese31Minor allele frequency- T:0.32MN 184
    rs32114001,2
    F--37956201(+) CTTCCG/CTCTAT 1 -- ut311Minor allele frequency- C:0.16MN 184
    rs1136549931,2
    F--41499355(-) TGTCTC/TTCTTT 1 -- int12Minor allele frequency- T:0.50CSA 4
    rs578437221,2
    C,F--41504394(+) ACATAT/CGTATA 1 -- int11Minor allele frequency- C:0.00WA 2
    rs1413081231,2
    C--41504583(+) TTTGG-/TTTTTT 1 -- int10--------
    rs594230781,2
    C--41507846(+) TTTTTT/-CTGAG 1 -- int12Minor allele frequency- -:0.00NA CSA 4
    rs582216501,2
    C--41512249(+) TTTTT-/T/T   
       T
    /TTT
    GTAGA
    2 -- int1 cds11NA 2
    rs106173071,2
    C--41513530(+) GCTAA-/T/TT  
            
    TTTTT
    1 -- int11CSA 2

    HapMap Linkage Disequilibrium report for CYP2B6 (41497204 - 41524303 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for CYP2B6 (see all 17):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2658055CNV Deletion23128226
    esv2718571CNV Deletion23290073
    esv2718572CNV Deletion23290073
    nsv509743CNV Insertion20534489
    dgv408n27CNV Loss19166990
    nsv433319CNV Loss18776910
    esv2597443CNV Loss19546169
    nsv470141CNV Loss18288195
    nsv517597CNV Loss19592680
    dgv55n17CNV Loss16327808

    The Human Cytochrome P450 Allele Nomenclature Database: CYP2B6 
    Human Gene Mutation Database (HGMD): CYP2B6
    Locus Specific Mutation Databases (LSDB): CYP2B6

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CYP2B6
    DNA2.0 Custom Variant and Variant Library Synthesis for CYP2B6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 123930   
    OMIM disorders: 614546  
    6 diseases for CYP2B6:    
    About MalaCards
    acute frontal sinusitis    efavirenz, poor metabolism of    efavirenz central nervous system toxicity    frontal sinusitis
    sinusitis    hiv/aids

    2 diseases from the University of Copenhagen DISEASES database for CYP2B6:
    Acute frontal sinusitis     Liver disease

    Find genes that share disorders with CYP2B6           About GenesLikeMe

    Selected Novoseek inferred disease relationships for CYP2B6 gene (see all 21)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    chemical carcinogenesis 27.9 1 1720447 (1)
    immunodeficiency 12.7 3 19531981 (1), 17918089 (1), 19433561 (1)
    hypertrophy 5.6 3 18243468 (1), 19363144 (1), 2400826 (1)
    tumors 4.12 24 12872138 (4), 12460909 (2), 9766669 (2), 19666990 (2) (see all 13)
    carcinoma 3.25 1 9506744 (1)
    virus infection 2.58 2 9249253 (2)
    stroke 1.97 1 18332082 (1)
    metastasis 0.619 2 15897573 (1)
    leukemia 0 1 11090860 (1)
    necrosis 0 2 17576808 (1), 1720447 (1), 18206661 (1)

    Genetic Association Database (GAD): CYP2B6
    Human Genome Epidemiology (HuGE) Navigator: CYP2B6 (133 documents)

    Export disorders for CYP2B6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CYP2B6 gene, integrated from 10 sources (see all 682):
    (articles sorted by number of sources associating them with CYP2B6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Pharmacogenetics of efavirenz and central nervous system side effects: an Adult AIDS Clinical Trials Group study. (PubMed id 15622315)1, 2, 4, 9 Haas D.W.... Acosta E.P. (AIDS 2004)
    2. Influence of host genetic factors on efavirenz plasma and intracellular pharmacokinetics in HIV-1-infected patients. (PubMed id 20860463)1, 2, 4 Elens L....Haufroid V. (Pharmacogenomics 2010)
    3. Haplotype structure of CYP2B6 and association with plasma efavirenz concentrations in a Chilean HIV cohort. (PubMed id 20639527)1, 2, 4 Carr D.F.... Cortes C.P. (J. Antimicrob. Chemother. 2010)
    4. Regulation of CYP2B6 in primary human hepatocytes by prototypical inducers. (PubMed id 14977870)1, 7, 9 Faucette S.R....LeCluyse E.L. (Drug Metab. Dispos. 2004)
    5. Bupropion and 4-OH-bupropion pharmacokinetics in relation to genetic polymorphisms in CYP2B6. (PubMed id 14515060)1, 4, 9 Kirchheiner J....BrockmAPller J. (Pharmacogenetics 2003)
    6. Smoking, alcoholism and genetic polymorphisms alter CYP2B6 levels in human brain. (PubMed id 12814665)1, 4, 9 Miksys S....Tyndale R.F. (Neuropharmacology 2003)
    7. Functional characterization of cytochrome P450 2B6 allelic variants. (PubMed id 12642465)1, 2, 9 Jinno H.... Ando M. (Drug Metab. Dispos. 2003)
    8. Successful efavirenz dose reduction in HIV type 1-infected individuals with cytochrome P450 2B6 *6 and *26. (PubMed id 17918089)1, 4, 9 Gatanaga H....Oka S. (Clin. Infect. Dis. 2007)
    9. Prevalence of CYP2B6 alleles in malaria-endemic populations of West Africa and Papua New Guinea. (PubMed id 16506047)1, 4, 9 Mehlotra R.K....Zimmerman P.A. (Eur. J. Clin. Pharmacol. 2006)
    10. CYP2B6 (c.516G--&gt;T) and CYP2A6 (*9B and/or *17) polymorphisms are independent predictors of efavirenz plasma concentrations in HIV-infected patients. (PubMed id 19371316)1, 4, 9 Kwara A....Court M.H. (Br J Clin Pharmacol 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1555 HGNC: 2615 AceView: CYP2B6 Ensembl:ENSG00000197408 euGenes: HUgn1555
    ECgene: CYP2B6 Kegg: 1555 H-InvDB: CYP2B6

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CYP2B6 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CYP2B6 Genetics and Cytogenetics in Oncology and Haematology
    Cytochrome P450 Allele Nomenclature Committeehttp://www.cypalleles.ki.se/cyp2b6.htm
    NIEHS-SNPshttp://egp.gs.washington.edu/data/cyp2b6/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CYP2B6 gene:
    Search GeneIP for patents involving CYP2B6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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