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CYP2A7 Gene

protein-coding   GIFtS: 53
GCID: GC19M041381

Cytochrome P450, Family 2, Subfamily A, Polypeptide 7

(Previous names: cytochrome P450, subfamily IIA (phenobarbital-inducible),...)
  Search for CYP2A7
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cytochrome P450, Family 2, Subfamily A, Polypeptide 71 2     CPAD2
Cytochrome P450, Subfamily IIA (Phenobarbital-Inducible), Polypeptide 71 2     CYP2A2
Cytochrome P450 IIA42 3     P450-IIA42
CYPIIA72 3     Cytochrome P450 2A72
EC 1.14.14.13 8     Cytochrome P450IIA42
CPA72     

External Ids:    HGNC: 26111   Entrez Gene: 15492   Ensembl: ENSG000001980777   OMIM: 6080545   UniProtKB: P208533   

Export aliases for CYP2A7 gene to outside databases

Previous GC identifers: GC19M042020 GC19M041773 GC19M046002 GC19M046018 GC19M046020 GC19M046073 GC19M041350


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CYP2A7 Gene:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are
monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids
and other lipids. This protein localizes to the endoplasmic reticulum; its substrate has not yet been determined.
This gene, which produces two transcript variants, is part of a large cluster of cytochrome P450 genes from the
CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. (provided by RefSeq, Jul 2008)

GeneCards Summary for CYP2A7 Gene:
CYP2A7 (cytochrome P450, family 2, subfamily A, polypeptide 7) is a protein-coding gene. GO annotations related to this gene include electron carrier activity and heme binding. An important paralog of this gene is CYP2W1.

UniProtKB/Swiss-Prot: CP2A7_HUMAN, P20853
Function: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is
involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated
compounds, including steroids, fatty acids, and xenobiotics

Gene Wiki entry for CYP2A7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the CYP2A7 gene promoter:
         USF1   SREBP-1a   USF-1   GCNF   GCNF-1   IRF-7A   STAT3   GCNF-2   SREBP-1b   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CYP2A7 promoter sequence
   Search Chromatin IP Primers for CYP2A7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CYP2A7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.2   Ensembl cytogenetic band:  19q13.2   HGNC cytogenetic band: 19q13.2

CYP2A7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CYP2A7 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M041381:  view genomic region     (about GC identifiers)

Start:
41,381,344 bp from pter      End:
41,388,657 bp from pter
Size:
7,314 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CP2A7_HUMAN, P20853 (See protein sequence)
Recommended Name: Cytochrome P450 2A7  
Size: 494 amino acids; 56425 Da
Cofactor: Heme group (By similarity)
Secondary accessions: Q13121

Explore the universe of human proteins at neXtProt for CYP2A7: NX_P20853

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for CYP2A7 (P20853) (see all 21)
     GKLPPGP  PGPTPLP  LLLMKHP  EERIQEE 

    REFSEQ proteins (2 alternative transcripts): 
    NP_000755.2  NP_085079.2  

    ENSEMBL proteins: 
     ENSP00000301146   ENSP00000470933   ENSP00000291764  
    Reactome Protein details: P20853

    CYP2A7 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CYP: Cytochrome P450s

    IUPHAR Guide to PHARMACOLOGY protein family classification: CYP2A7
    CYP2 family

    4 InterPro protein domains:
     IPR001128 Cyt_P450
     IPR017972 Cyt_P450_CS
     IPR002401 Cyt_P450_E_grp-I
     IPR008067 Cyt_P450_E_grp-I_CYP2A-like

    Graphical View of Domain Structure for InterPro Entry P20853

    ProtoNet protein and cluster: P20853

    2 Blocks protein domains:
    IPB002401 E-class P450 group I signature
    IPB008067 CYP2A P450 family signature


    UniProtKB/Swiss-Prot: CP2A7_HUMAN, P20853
    Similarity: Belongs to the cytochrome P450 family


    CYP2A7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CP2A7_HUMAN, P20853
    Function: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is
    involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated
    compounds, including steroids, fatty acids, and xenobiotics
    Catalytic activity: RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O
    Induction: P450 can be induced to high levels in liver and other tissues by various foreign compounds, including
    drugs, pesticides, and carcinogens

         Genatlas biochemistry entry for CYP2A7:
    cytochrome P450,subfamily IIA (phenobarbital-inducible),polypeptide 7

         Enzyme Number (IUBMB): EC 1.14.14.11 2

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004497monooxygenase activity ----
    GO:0005506iron ion binding IEA--
    GO:0016705oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen ----
    GO:0019825oxygen binding TAS7864805
    GO:0020037heme binding IEA--
         
    CYP2A7 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for CYP2A7:
     Decreased Hepatitis C virus re  Increased G1 DNA content 

    Animal Models:
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    Sino Biological Human cDNA Clone for CYP2A7
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CYP2A7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CYP2A7

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CP2A7_HUMAN, P20853: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral
    membrane protein

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane IEA--

    CYP2A7 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CYP2A7 About    
    See pathways by source

    SuperPathContained pathways About
    1Cytochrome P450 - arranged by substrate type
    Cytochrome P450 - arranged by substrate type0.75
    Xenobiotics0.00
    Phase 1 - Functionalization of compounds0.75
    Fatty acids0.00
    cytochrome P4500.74
    CYP2E1 reactions0.00
    2Biological oxidations
    Biological oxidations0.56
    metapathway biotransformation0.42
    3Metabolism
    Metabolism0.38

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for CYP2A7
        cytochrome P450
    metapathway biotransformation


    3 Reactome Pathways for CYP2A7
        Fatty acids
    Xenobiotics
    CYP2E1 reactions



    CYP2A7 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CYP2A7
    Interactions:

        Search GeneGlobe Interaction Network for CYP2A7

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0055114oxidation-reduction process ----

    CYP2A7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CYP2A7 (CP2A7)

    Selected HMDB Compounds for CYP2A7 (see all 49)    About this table
    CompoundSynonyms CAS #PubMed Ids
    10-HETE10-hydroxyeicosa-all-cis-5,8,11,14-tetraenoate (see all 2)167697-52-1--
    11,12,15-THETA11,12,15-Trihydroxyicosatrienoic acid (see all 5)----
    11,12-Epoxyeicosatrienoic acid10-(3-(2-octenyl)oxiranyl)-5,8-Decadienoic acid (see all 15)81276-02-0--
    11,14,15-THETA(5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoic acid (see all 8)----
    11H-14,15-EETA14,15-Ep-11-HETrE (see all 11)219535-29-2--
    11beta-Hydroxytestosterone11beta,17beta-dihydroxyandrost-4-en-3-one 1816-85-9--
    12,13-EpOMEVernolic acid (see all 12)----
    13-HETE13-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoate (see all 2)151910-72-4--
    14,15-Epoxy-5,8,11-eicosatrienoic acid(5Z,8Z,11Z)-14,15-Epoxyicosa-5.8.11-trienoic acid (see all 11)81276-03-1--
    15(S)-HPETE(5Z,8Z,11Z,13E)-(15S)-15-Hydroperoxyicosa-5,8,11,13-tetraenoate (see all 8)70981-96-3--

    2 Novoseek inferred chemical compound relationships for CYP2A7 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    coumarin 74.4 1 11016631 (1)
    nicotine 61.7 1 11016631 (1)



    CYP2A7 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CYP2A7 gene (2 alternative transcripts): 
    NM_000764.2  NM_030589.2  

    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000301146(uc002opm.3 uc002opo.3) ENST00000602008 ENST00000598264
    ENST00000594332 ENST00000291764(uc002opn.3)
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat CYP2A7
      QuantiFast Probe-based Assays in human, mouse, rat CYP2A7

    Selected AceView cDNA sequences (see all 114):

    AV661332 NM_030589 NM_000764 NM_000762 BV207404 CB133207 AV650260 X13929 
    CB142718 CB121445 CB133199 CB138212 AV661895 CB146612 CB137671 CB130051 
    CB111964 CA945249 BM979947 M33318 M33317 CB135600 CB116943 BQ302898 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CYP2A7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CYP2A7 Expression
    About this image

    CYP2A7 Protein expression data from MOPED1, PaxDb2 and MaxQB3 --
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CYP2A7 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cyp2a51 cytochrome P450, family 2, subfamily a, polypeptide more 84.55(n)
    83.92(a)
      13087  NM_007812.4  NP_031838.2 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 15)
    Uncharacterized protein
    (see all 15)
    59(a)
    58(a)
    (see all 15)
    many ↔ many
    many ↔ many
    (see all 15)
    LGf(3035082-3170592)
    AAWZ02038417(567-11161)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC5483741 cytochrome P450, family 2 58.59(n)
    54.7(a)
      548374  XM_002939378.2  XP_002939424.2 
    worm
    (Caenorhabditis elegans)
    Secernentea K09A11.33
    cyp-36A11
    Cytochrome P4503
    cyp-36A11
    34(a)
    (best of 36)3
    43.65(n)1
    34.18(a)1
      X(13302830-13304898)3
    1831931  NM_059866.41  NP_492267.11 


    ENSEMBL Gene Tree for CYP2A7 (if available)
    TreeFam Gene Tree for CYP2A7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CYP2A7 gene
    CYP2A61 2  CYP2A131 2  CYP2W12  CYP2C82  CYP2F12  CYP2B62  CYP2C192  CYP2R12  
    CYP2J22  CYP2U12  CYP2S12  CYP2E12  CYP2C92  CYP2D62  CYP2C182  
    Selected SIMAP similar genes for CYP2A7 using alignment to 5 protein entries:     CP2A7_HUMAN (see all proteins) (see all similar genes):
    CYP2A6    CYP2A6V2    CYP2A13    CYP2G1P    CYP2C    CYP2B
    CYP2B7    CYP2C8    CYP 2C    CYP2C9    CYP2C19    CYP2S1
    CYP2F1    CYP2E1    CYP2C18    CYP2J2    CYP2R1    CYP2B6

    CYP2A7 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CYP2A7 (see all 493)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs285532801,2
    C--41380968(+) ACACCC/TGGGTA 2 -- ds50010--------
    rs16456951,2
    C,O,A--41381055(-) TGGGGA/GGTTTT 2 -- ds50011Minor allele frequency- G:0.00NA 2
    rs1118550191,2
    C--41381116(+) GGAATG/AGGTGG 2 -- ds50011Minor allele frequency- A:0.50NA 2
    rs1138776891,2
    C--41381121(+) GGGTGG/CTTTTT 2 -- ds50011Minor allele frequency- C:0.50NA 2
    rs1127033841,2
    C,F--41381133(+) AGAATG/CTGTCT 2 -- ds50011Minor allele frequency- C:0.50NA 2
    rs1121618611,2
    C,F--41381142(+) CTAGAG/AGGCTA 2 -- ds50011Minor allele frequency- A:0.50NA 2
    rs1173312581,2
    C,F--41381230(+) CTCAGC/TTTTGT 2 -- ds50011Minor allele frequency- T:0.01NA 120
    rs1826992581,2
    --41381265(+) TTTTCC/GCCTTC 2 -- ds50010--------
    rs1498251131,2
    --41381275(+) CGCAGA/CGGTTT 2 -- ds50010--------
    rs730489761,2
    C,F--41381310(+) GCAATA/GGTTTT 2 -- ds50016Minor allele frequency- G:0.14NA CSA WA EA 364

    HapMap Linkage Disequilibrium report for CYP2A7 (41381344 - 41388657 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for CYP2A7 (see all 20):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2718569CNV Deletion23290073
    esv2718570CNV Deletion23290073
    esv2718568CNV Deletion23290073
    dgv643e199CNV Deletion23128226
    esv1001236CNV Deletion20482838
    dgv563e201CNV Deletion23290073
    nsv435697CNV Deletion17901297
    dgv3878n71CNV Loss21882294
    nsv9729CNV Loss18304495
    dgv3876n71CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608054    OMIM disorders: --


    CYP2A7 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CYP2A7
    Human Genome Epidemiology (HuGE) Navigator: CYP2A7 (8 documents)

    Export disorders for CYP2A7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CYP2A7 gene, integrated from 10 sources (see all 27):
    (articles sorted by number of sources associating them with CYP2A7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A genetic polymorphism in coumarin 7-hydroxylation: sequence of the human CYP2A genes and identification of variant CYP2A6 alleles. (PubMed id 7668294)1, 2, 3, 9 Fernandez-Salguero P.... Idle J.R. (Am. J. Hum. Genet. 1995)
    2. Characterization of a novel CYP2A7/CYP2A6 hybrid allele (CYP2A6*12) that causes reduced CYP2A6 activity. (PubMed id 12325023)1, 4, 9 Oscarson M....Ingelman-Sundberg M. (Hum. Mutat. 2002)
    3. Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants. (PubMed id 15128046)1, 3 Nelson D.R....Nebert D.W. (Pharmacogenetics 2004)
    4. The CYP2A3 gene product catalyzes coumarin 7-hydroxylation in human liver microsomes. (PubMed id 2322567)1, 2 Yamano S.... Gonzalez F.J. (Biochemistry 1990)
    5. Expression and alternative splicing of the cytochrome P-450 CYP2A7. (PubMed id 7864805)1, 9 Ding S....Wolf C.R. (Biochem. J. 1995)
    6. Expression of CYP2A genes in human liver and extrahepatic tissues. (PubMed id 10353262)1, 9 Koskela S....Raunio H. (Biochem. Pharmacol. 1999)
    7. Differential distribution of CYP2A6 and CYP2A13 in the human respiratory tract. (PubMed id 22890016)1 Chiang H.C....Tsou T.C. ( international review of thoracic diseases 2012)
    8. Single-nucleotide polymorphisms, acute rejection, and severity of tubulitis in kidney transplantation, accounting for center-to-center variation. (PubMed id 21085059)4 Israni A....Oetting W.S. (Transplantation 2010)
    9. CYP2A7 polymorphic alleles confound the genotyping of CYP2A6*4A allele. (PubMed id 16636685)1 Fukami T....Yokoi T. (Pharmacogenomics J. 2006)
    10. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (Nature 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1549 HGNC: 2611 AceView: CYP2A6andCYP2A7 Ensembl:ENSG00000198077 euGenes: HUgn1549
    ECgene: CYP2A7 H-InvDB: CYP2A7

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CYP2A7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CYP2A7 gene:
    Search GeneIP for patents involving CYP2A7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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