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Aliases for CYP2A7 Gene

Aliases for CYP2A7 Gene

  • Cytochrome P450 Family 2 Subfamily A Member 7 2 3 5
  • Cytochrome P450, Subfamily IIA (Phenobarbital-Inducible), Polypeptide 7 2 3
  • Cytochrome P450, Family 2, Subfamily A, Polypeptide 7 2 3
  • Cytochrome P450 IIA4 3 4
  • EC 4 63
  • CYPIIA7 3 4
  • Cytochrome P450IIA4 3
  • P450-IIA4 3
  • CYP2A 3
  • CPAD 3
  • CPA7 3

External Ids for CYP2A7 Gene

Previous GeneCards Identifiers for CYP2A7 Gene

  • GC19M042020
  • GC19M041773
  • GC19M046002
  • GC19M046018
  • GC19M046020
  • GC19M046073
  • GC19M041350
  • GC19M041381

Summaries for CYP2A7 Gene

Entrez Gene Summary for CYP2A7 Gene

  • This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum; its substrate has not yet been determined. This gene, which produces two transcript variants, is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. [provided by RefSeq, Jul 2008]

GeneCards Summary for CYP2A7 Gene

CYP2A7 (Cytochrome P450 Family 2 Subfamily A Member 7) is a Protein Coding gene. Among its related pathways are Phenytoin Pathway, Pharmacokinetics and Phase II conjugation. GO annotations related to this gene include iron ion binding and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen. An important paralog of this gene is CYP2C19.

UniProtKB/Swiss-Prot for CYP2A7 Gene

  • Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Gene Wiki entry for CYP2A7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYP2A7 Gene

Genomics for CYP2A7 Gene

Regulatory Elements for CYP2A7 Gene

Enhancers for CYP2A7 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CYP2A7 on UCSC Golden Path with GeneCards custom track

Genomic Location for CYP2A7 Gene

40,875,439 bp from pter
40,882,752 bp from pter
7,314 bases
Minus strand

Genomic View for CYP2A7 Gene

Genes around CYP2A7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CYP2A7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CYP2A7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYP2A7 Gene

Proteins for CYP2A7 Gene

  • Protein details for CYP2A7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cytochrome P450 2A7
    Protein Accession:
    Secondary Accessions:
    • Q13121

    Protein attributes for CYP2A7 Gene

    494 amino acids
    Molecular mass:
    56425 Da
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Quaternary structure:
    No Data Available

neXtProt entry for CYP2A7 Gene

Proteomics data for CYP2A7 Gene at MOPED

Post-translational modifications for CYP2A7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CYP2A7 Gene

Domains & Families for CYP2A7 Gene

Gene Families for CYP2A7 Gene

Suggested Antigen Peptide Sequences for CYP2A7 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the cytochrome P450 family.
  • Belongs to the cytochrome P450 family.
genes like me logo Genes that share domains with CYP2A7: view

Function for CYP2A7 Gene

Molecular function for CYP2A7 Gene

GENATLAS Biochemistry:
cytochrome P450,subfamily IIA (phenobarbital-inducible),polypeptide 7
UniProtKB/Swiss-Prot CatalyticActivity:
RH + [reduced NADPH--hemoprotein reductase] + O(2) = ROH + [oxidized NADPH--hemoprotein reductase] + H(2)O.
UniProtKB/Swiss-Prot Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
UniProtKB/Swiss-Prot Induction:
P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Enzyme Numbers (IUBMB) for CYP2A7 Gene

Gene Ontology (GO) - Molecular Function for CYP2A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005506 iron ion binding IEA --
GO:0008395 steroid hydroxylase activity IBA --
GO:0019825 oxygen binding TAS 7864805
genes like me logo Genes that share ontologies with CYP2A7: view
genes like me logo Genes that share phenotypes with CYP2A7: view

Animal Models for CYP2A7 Gene

MGI Knock Outs for CYP2A7:

Animal Model Products

CRISPR Products

miRNA for CYP2A7 Gene

miRTarBase miRNAs that target CYP2A7

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CYP2A7 Gene

Localization for CYP2A7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYP2A7 Gene

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Subcellular locations from

Jensen Localization Image for CYP2A7 Gene COMPARTMENTS Subcellular localization image for CYP2A7 gene
Compartment Confidence
endoplasmic reticulum 5
golgi apparatus 2
extracellular 1
nucleus 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for CYP2A7 Gene

Pathways & Interactions for CYP2A7 Gene

genes like me logo Genes that share pathways with CYP2A7: view

Pathways by source for CYP2A7 Gene

Interacting Proteins for CYP2A7 Gene

Gene Ontology (GO) - Biological Process for CYP2A7 Gene


No data available for SIGNOR curated interactions for CYP2A7 Gene

Drugs & Compounds for CYP2A7 Gene

(19) Drugs for CYP2A7 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Citalopram Approved Pharma 497
Codeine Approved, Illicit Pharma Full agonist, Agonist 69
Estradiol Approved, Investigational Pharma Sex hormone 1235
Estrone Approved Pharma Agonist Estrogenic hormone 19
Testosterone Approved, Investigational Pharma Endogenous androgen receptor agonist 519

(24) Additional Compounds for CYP2A7 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • 11,12,15-TriHETRE
  • 11,12,15-Trihydroxyicosatrienoate
  • 11,12,15-Trihydroxyicosatrienoic acid
  • 11,12,15S-Trihydroxy-5Z,8Z,13E-eicosatrienoate
  • 11,12,15S-Trihydroxy-5Z,8Z,13E-eicosatrienoic acid
11,12-Epoxyeicosatrienoic acid
  • (5Z,8Z,14Z)-11,12-Epoxyeicosa-5,8,14-trienoate
  • (5Z,8Z,14Z)-11,12-Epoxyeicosa-5,8,14-trienoic acid
  • (5Z,8Z,14Z)-11,12-Epoxyicosa-5,8,14-trienoate
  • (5Z,8Z,14Z)-11,12-Epoxyicosa-5,8,14-trienoic acid
  • 10-(3-(2-Octenyl)oxiranyl)-5,8-Decadienoate
  • (5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoate
  • (5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoic acid
  • (5Z,8Z,12E)-11,14,15-Trihydroxyicosa-5,8,12-trienoate
  • (5Z,8Z,12E)-11,14,15-Trihydroxyicosa-5,8,12-trienoic acid
  • 11,14,15-Trihydroxy-5Z,8Z,12E-eicosatrienoate
  • (5Z,8Z,12E)-14,15-Epoxy-11-hydroxyeicosa-5,8,12-trienoate
  • (5Z,8Z,12E)-14,15-Epoxy-11-hydroxyeicosa-5,8,12-trienoic acid
  • (5Z,8Z,12E)-14,15-Epoxy-11-hydroxyicosa-5,8,12-trienoate
  • (5Z,8Z,12E)-14,15-Epoxy-11-hydroxyicosa-5,8,12-trienoic acid
  • 11-Hydroxy-14,15-EETA
  • (+/-)-12(13)-epoxy-9Z-octadecenoate
  • (+/-)-12(13)-epoxy-9Z-octadecenoic acid
  • (9Z)-11-(3-pentyloxiran-2-yl)undec-9-enoate
  • (9Z)-11-(3-pentyloxiran-2-yl)undec-9-enoic acid
  • (9Z)-12,13-epoxyoctadecenoate
genes like me logo Genes that share compounds with CYP2A7: view

Transcripts for CYP2A7 Gene

Unigene Clusters for CYP2A7 Gene

Cytochrome P450, family 2, subfamily A, polypeptide 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CYP2A7 Gene

No ASD Table

Relevant External Links for CYP2A7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CYP2A7 Gene

mRNA expression in normal human tissues for CYP2A7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CYP2A7 Gene

This gene is overexpressed in Liver (x50.6).

SOURCE GeneReport for Unigene cluster for CYP2A7 Gene Hs.719890

genes like me logo Genes that share expression patterns with CYP2A7: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for CYP2A7 Gene

Orthologs for CYP2A7 Gene

This gene was present in the common ancestor of animals.

Orthologs for CYP2A7 Gene

Organism Taxonomy Gene Similarity Type Details
(Mus musculus)
Mammalia Cyp2a5 35
  • 84.55 (n)
  • 83.92 (a)
Cyp2a5 16
Cyp2a12 36
  • 71 (a)
Cyp2a22 36
  • 71 (a)
Cyp2a4 36
  • 82 (a)
Cyp2a5 36
  • 84 (a)
(Rattus norvegicus)
Mammalia Cyp2a3 35
  • 83.99 (n)
  • 84.76 (a)
(Bos Taurus)
Mammalia -- 36
  • 87 (a)
(Canis familiaris)
Mammalia CYP2A13 36
  • 84 (a)
CYP2A13 36
  • 87 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 58 (a)
(Pan troglodytes)
Mammalia CYP2A7 36
  • 98 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 58 (a)
-- 36
  • 52 (a)
-- 36
  • 58 (a)
-- 36
  • 54 (a)
-- 36
  • 58 (a)
-- 36
  • 46 (a)
-- 36
  • 54 (a)
-- 36
  • 53 (a)
-- 36
  • 53 (a)
-- 36
  • 59 (a)
-- 36
  • 57 (a)
-- 36
  • 56 (a)
-- 36
  • 54 (a)
-- 36
  • 55 (a)
-- 36
  • 56 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC548374 35
  • 58.59 (n)
  • 54.7 (a)
(Caenorhabditis elegans)
Secernentea B0213.10 37
  • 28 (a)
B0213.11 37
  • 30 (a)
B0213.12 37
  • 30 (a)
B0213.14 37
  • 30 (a)
B0213.15 37
  • 31 (a)
B0213.16 37
  • 30 (a)
B0304.3 37
  • 30 (a)
C03G6.14 37
  • 28 (a)
C03G6.15 37
  • 30 (a)
C25E10.2 37
  • 26 (a)
C34B7.3 37
  • 33 (a)
C41G6.1 37
  • 27 (a)
C45H4.17 37
  • 30 (a)
C45H4.2 37
  • 29 (a)
C49C8.4 37
  • 31 (a)
C49G7.8 37
  • 28 (a)
C50H11.15 37
  • 33 (a)
F14H3.10 37
  • 29 (a)
F41B5.2 37
  • 31 (a)
F41B5.3 37
  • 31 (a)
F41B5.7 37
  • 28 (a)
F42A9.5 37
  • 32 (a)
K05D4.4 37
  • 33 (a)
K07C6.2 37
  • 29 (a)
K07C6.3 37
  • 29 (a)
K07C6.4 37
  • 26 (a)
K07C6.5 37
  • 30 (a)
K09A11.2 37
  • 32 (a)
K09A11.3 37
  • 34 (a)
K09A11.4 37
  • 33 (a)
K09D9.2 37
  • 28 (a)
R08F11.3 37
  • 31 (a)
T09H2.1 37
  • 26 (a)
T10H4.10 37
  • 31 (a)
T10H4.11 37
  • 30 (a)
Y5H2B.6 37
  • 28 (a)
cyp-36A1 35
  • 43.65 (n)
  • 34.18 (a)
Species with no ortholog for CYP2A7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for CYP2A7 Gene

Gene Tree for CYP2A7 (if available)
Gene Tree for CYP2A7 (if available)

Paralogs for CYP2A7 Gene

genes like me logo Genes that share paralogs with CYP2A7: view

Variants for CYP2A7 Gene

Sequence variations from dbSNP and Humsavar for CYP2A7 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10425176 - 40,881,751(+) ACTGA(A/G/T)CTGAT intron-variant, nc-transcript-variant, reference, missense
rs10425169 - 40,881,742(+) ATAGC(A/G)CTCAC intron-variant, nc-transcript-variant, reference, missense
rs4079366 - 40,878,770(-) CATCC(A/G/T)CATGC nc-transcript-variant, reference, missense
rs2545754 - 40,877,923(+) TGCCT(C/G)CAATG nc-transcript-variant, reference, missense
rs3869579 - 40,877,894(+) ATAGC(A/G)CAGGG nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for CYP2A7 Gene

Variant ID Type Subtype PubMed ID
dgv1084e1 CNV Complex 17122850
dgv3872n71 CNV Gain 21882294
esv21610 CNV Gain+Loss 19812545
nsv9729 CNV Loss 18304495
dgv3875n71 CNV Gain 21882294
esv2718568 CNV Deletion 23290073
esv33053 CNV Gain 17666407
nsv911739 CNV Gain+Loss 21882294
dgv3876n71 CNV Loss 21882294
dgv3877n71 CNV Gain+Loss 21882294
dgv3878n71 CNV Loss 21882294
nsv435697 CNV Deletion 17901297
dgv563e201 CNV Deletion 23290073
dgv643e199 CNV Deletion 23128226
nsv911760 CNV Gain+Loss 21882294
nsv511622 CNV Loss 21212237
esv2718569 CNV Deletion 23290073
esv1005181 CNV Gain 20482838
esv1001236 CNV Deletion 20482838
esv2718570 CNV Deletion 23290073

Variation tolerance for CYP2A7 Gene

Residual Variation Intolerance Score: 99.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.84; 91.75% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CYP2A7 Gene

Disorders for CYP2A7 Gene

Relevant External Links for CYP2A7

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CYP2A7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CYP2A7 Gene

Publications for CYP2A7 Gene

  1. A genetic polymorphism in coumarin 7-hydroxylation: sequence of the human CYP2A genes and identification of variant CYP2A6 alleles. (PMID: 7668294) Fernandez-Salguero P. … Idle J.R. (Am. J. Hum. Genet. 1995) 2 3 4 23 67
  2. Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants. (PMID: 15128046) Nelson D.R. … Nebert D.W. (Pharmacogenetics 2004) 2 3
  3. Characterization of a novel CYP2A7/CYP2A6 hybrid allele (CYP2A6*12) that causes reduced CYP2A6 activity. (PMID: 12325023) Oscarson M. … Ingelman-Sundberg M. (Hum. Mutat. 2002) 3 23
  4. Expression of CYP2A genes in human liver and extrahepatic tissues. (PMID: 10353262) Koskela S. … Raunio H. (Biochem. Pharmacol. 1999) 3 23
  5. Expression and alternative splicing of the cytochrome P-450 CYP2A7. (PMID: 7864805) Ding S. … Wolf C.R. (Biochem. J. 1995) 3 23

Products for CYP2A7 Gene

Sources for CYP2A7 Gene