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CYP2A6 Gene

protein-coding GIFtS: 65

GC19M046041

cytochrome P450, family 2, subfamily A, polypeptide 6
(Previous names: cytochrome P450, subfamily IIA (phenobarbital-inducible), polypeptide 6 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: CYP2A3)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
CPA6 ^¹, ²
CYP2A ^¹, ², ⁵
CYP2A3 ^², ³, ⁵
CYPIIA6 ^³
EC 1.14.14.1 ^³
P450(I) ^³
P450C2A ^², ⁵
P450PB ^²

Descriptions
Coumarin 7-hydroxylase ^², ³
P450 IIA3 ^³
cytochrome P450, family 2, subfamily A, polypeptide 6 ^²
cytochrome P450, subfamily IIA (phenobarbital-inducible), polypeptide 6 ^¹, ²
flavoprotein-linked monooxygenase ^²
xenobiotic monooxygenase ^²

External Ids
HGNC: 2610¹
Entrez Gene: 1548²
UniProtKB: P11509³
Ensembl: ENSG00000213052⁷

Search outside databases for aliases for CYP2A6 gene

Previous GC identifers: GC19M041988 GC19M041741 GC19M046001 GC19M046017 GC19M046019

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for CYP2A6:

This gene, CYP2A6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome

P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and

synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic

reticulum and its expression is induced by phenobarbital. The enzyme is known to hydroxylate

coumarin, and also metabolizes nicotine, aflatoxin B1, nitrosamines, and some pharmaceuticals.

Individuals with certain allelic variants are said to have a poor metabolizer phenotype, meaning

they do not efficiently metabolize coumarin or nicotine. This gene is part of a large cluster of

cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. The gene was

formerly referred to as CYP2A3; however, it has been renamed CYP2A6. [provided by RefSeq]

UniProtKB/Swiss-Prot: CP2A6_HUMAN, P11509

Function: Exhibits a high coumarin 7-hydroxylase activity. Can act in the hydroxylation of the

anti-cancer drugs cyclophosphamide and ifosphamide. Competent in the metabolic activation of

aflatoxin B1. Constitutes the major nicotine C-oxidase

Gene Wiki entry for CYP2A6

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the CYP2A6 gene

Entrez Gene cytogenetic band: 19q13.2 Ensembl cytogenetic band: 19q13.2 HGNC cytogenetic band: 19q13.2

CYP2A6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19M046041: (about GC identifiers)

Start:	46,041,284 bp from pter
End:	46,048,180 bp from pter
Size:	6,897 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000019.8 NT_011109.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: CP2A6_HUMAN, P11509 (See protein sequence)

Recommended Name: Cytochrome P450 2A6

Size: 494 amino acids; 56517 Da

Cofactor: Heme group

Subcellular location: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome

membrane; Peripheral membrane protein

PDB structures from and Proteopedia :

1Z10 (3D)

1Z11 (3D)

2FDU (3D)

2FDV (3D)

2FDW (3D)

2FDY (3D)

Secondary accessions: A7YAE5 B2R7F6 P00190 P10890 Q16803 Q4VAT9 Q4VAU0 Q4VAU1 Q9H1Z7 Q9UCU0 Q9UK48

REFSEQ proteins: NP_000753.3

ENSEMBL proteins:

ENSP00000301141

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Sigma-Aldrich Proteins and AQUA Peptides for CYP2A6
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Cytochrome P450 2A6)
	Human Recombinant Proteins from Abnova (CYP2A6)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005783	endoplasmic reticulum	IEA	--
GO:0005789	endoplasmic reticulum membrane	IEA	--
GO:0005792	microsome	TAS	2322567
GO:0016020	membrane	IEA	--

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Antibodies for CYP2A6:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of CYP2A6
	Sigma-Aldrich Antibodies for CYP2A6
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (Cytochrome P450 2A6), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (CYP2A6)
	Novus Biologicals Antibodies for CYP2A6

Assays for CYP2A6:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P11509

ProtoNet protein and cluster: P11509

2 Blocks protein families:

IPB002401 E-class P450 group I signature

IPB008067 CYP2A P450 family signature

UniProtKB/Swiss-Prot: CP2A6_HUMAN, P11509

Similarity: Belongs to the cytochrome P450 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CYP2A6)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CYP2A6)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000762

Applied Biosystems Silencer® siRNAs for CYP2A6

Sigma-Aldrich siRNA and siRNA Panels for CYP2A6

Sigma-Aldrich shRNA for CYP2A6

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for CYP2A6
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_000762
Myc/DDK tagged cDNA clone in CMV expression vector: NM_000762
untagged cDNA clones in CMV expression vector (see all 2): NM_000762

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000762

UniProtKB/Swiss-Prot: CP2A6_HUMAN, P11509

Function: Exhibits a high coumarin 7-hydroxylase activity. Can act in the hydroxylation of the

anti-cancer drugs cyclophosphamide and ifosphamide. Competent in the metabolic activation of

aflatoxin B1. Constitutes the major nicotine C-oxidase

Catalytic activity: RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O

Induction: By phenobarbital and dexamethasone

Enzyme Number (IUBMB): EC 1.14.14.1

Genatlas biochemistry entry for CYP2A6:

cytochrome P450,subfamily IIA (phenobarbital-inducible),polypeptide 6,major nicotine c

oxidase,involved in nicotine elimination,susceptibility factor for nicotine addiction and lung

cancer,reduced by gene deletion,deleted in the poor metabolizer phenotype

5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008389	coumarin 7-hydroxylase activity	TAS	7864805
GO:0009055	electron carrier activity	IEA	--
GO:0019825	oxygen binding	TAS	9827545
GO:0020037	heme binding	IEA	--
GO:0046872	metal ion binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5/7 Sigma-Aldrich "Your Favorite Gene" Pathways for CYP2A6 (Your Favorite Gene powered by Ingenuity) (see all 7 )

Tryptophan Metabolism
Metabolism of Xenobiotics by Cytochrome P450
Fatty Acid Metabolism
PXR/RXR Activation
Arachidonic Acid Metabolism

GeneDecks CYP2A6 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for CYP2A6

5/21 Interacting proteins for CYP2A6 (ENSP00000301141³) via UniProtKB, MINT, and/or STRING (see all 21 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
AOX1	ENSP00000363832³	STRING (score=.956)
NAT2	ENSP00000286479³	STRING (score=.925)
NFIC	ENSP00000342859³	STRING (score=.869)
CYP1A2	ENSP00000342007³	STRING (score=.849)
PPIG	ENSP00000260970³	STRING (score=.843)

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1 Gene Ontology (GO) biological process term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0055114	oxidation reduction	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for CYP2A6

Sigma-Aldrich Small Molecules for CYP2A6:

Inhibitor

Browse Tocris compounds for CYP2A6
10/57 Novoseek chemical compound relationships for CYP2A6 gene (see all 57 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone	82.45	10	8022436 (1), 16176798 (1), 11259349 (1), 17139156 (1) (see all 9)
ethoxyresorufin	82.22	31	11585060 (2), 15093319 (1), 10224324 (1), 11700007 (1) (see all 24)
7-hydroxycoumarin	81.47	9	9806947 (2), 18840518 (1), 8739824 (1), 16914511 (1) (see all 5)
trans-3'-hydroxycotinine	79.88	2	12504349 (1), 19029401 (1)
s-warfarin	77.58	3	9416970 (2), 9186495 (1)
benzyloxyresorufin	76.44	9	11181500 (2), 8135852 (1), 9454825 (1), 10379985 (1) (see all 6)
7-ethoxycoumarin	75.95	14	8573198 (2), 7720526 (1), 10488716 (1), 10376770 (1) (see all 9)
dimethylnitrosamine	75.12	13	8378940 (2), 8071856 (1), 1472537 (1), 7773543 (1) (see all 10)
nitrosamines	74.10	14	14644339 (2), 15993850 (1), 17683511 (1), 8022436 (1) (see all 10)
cotinine	73.96	48	8627511 (5), 9316878 (3), 8937855 (3), 18004205 (3) (see all 21)

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10/10 PharmGKB drug compound relationships for CYP2A6 gene (see all 10 )

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
5-fluorouracil	PK FA GN	15454735 11106261
coumarin	FA GN	12325023
dexamethasone	PK FA	8114683
etoposide	PK FA	8114683
fadrozole	GN	12172220
fluorouracil	PK	12042667
midazolam	PK FA	8114683
nicotine	GN	15475735
rifampin	FA	11714868
teniposide	PK FA	8114683

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CYP2A6)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CYP2A6)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000762

Sigma-Aldrich siRNA and siRNA Panels for CYP2A6

Sigma-Aldrich shRNA for CYP2A6

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000762

REFSEQ mRNAs for CYP2A6 gene:

NM_000762.5

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000762

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000762
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000762
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_000762

Additional cDNA sequence:

AF182275.1 AK307740.1 AK309594.1 AK312964.1 BC096253.3 BC096254.1 BC096255.1 BC096256.1

BC117165.1 BC143325.1 K03192.1 M33317.1 M33318.1 U22029.1 U22030.1 U22044.1

X06401.1 X13897.1 X13929.1 X13930.1

12 DOTS entries:

DT.441444 DT.100796642 DT.102820753 DT.102836902 DT.121503458 DT.95161335 DT.92430530 DT.100796640

DT.121503361 DT.121503314 DT.92430534 DT.92430531

24/114 AceView cDNA sequences (see all 114 ):

AV661332 NM_000762 NM_000764 NM_030589 CB137781 CB116943 BV207402 CB142718

CB133199 CB137671 BV207403 CB146694 AV646570 BV207404 CB130051 CA945249

CB135600 CB147167 CB146612 CB124837 CB121445 CB148789 M33318 CB133207

highest scoring ESTs for CYP2A6:

M33318 X13930 AF182275 AV658078 AV661332 AV686508 AV693999 BC096253 BC096254 BC096255

Unigene Cluster for CYP2A6:

Cytochrome P450, family 2, subfamily A, polypeptide 6

Hs.250615 [show with all ESTs]

Unigene Representative Sequence: U22029

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000301141

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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CYP2A6 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for CYP2A6

¹ / ² / ³

12 probe-sets matching CYP2A6 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
1493_r_at²^{, 3}	U95-A	1	1.00	1.00	0.91	0.35	M33318	1.00	0.90	0.95	1
1494_f_at²^{, 3}	U133-A	4	1.00	0.52	0.99	1.59	M33318	1.00	0.90	0.95	1
1338_s_at²^{, 3}	U95-A	4	1.00	0.29	0.98	0.84	X13930	1.00	0.77	0.89	1
1492_f_at²^{, 3}	U95-A	4	0.88	0.34	0.98	1.43	M33317	0.20	0.10	0.16	3
207244_x_at²^{, 3}	U133-A	3	1.00	0.65	--	--	NM_000762	0.60	1.00	0.82	1
1494_f_at²^{, 3}	U133-A	4	1.00	0.52	--	--	M33318	1.00	0.90	0.95	1
211295_x_at²^{, 3}	U133-A	3	1.00	0.52	--	--	AF182275	0.80	0.88	0.84	1
214320_x_at²^{, 3}	U133-A	4	1.00	0.51	--	--	T67741	0.20	0.50	0.38	1
207244_x_at²	U133Plus2	3	1.00	0.65	--	--	--	--	--	--	--
1494_f_at²	U133Plus2	4	1.00	0.52	--	--	--	--	--	--	--
211295_x_at²	U133Plus2	3	1.00	0.52	--	--	--	--	--	--	--
214320_x_at²	U133Plus2	4	1.00	0.51	--	--	--	--	--	--	--

GeneDecks CYP2A6 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
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About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.250615
Expression variation in blood from EXPOLDB for CYP2A6
UniProtKB/Swiss-Prot: CP2A6_HUMAN, P11509
Tissue specificity: Liver

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for CYP2A6 gene from 5 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	LOC738823¹	--	similar to cytochrome P450 2A13 variant 5	81.91(n) 78.29(a)	738823 XM_001139878.1 XP_001139878.1
rat (Rattus norvegicus)	Cyp2a3a¹	--	cytochrome P450, family 2, subfamily A, polypeptide more	84.41(n) 85.63(a)	24299 NM_012542.1 NP_036674.1
mouse (Mus musculus)	Cyp2a5¹	--	cytochrome P450, family 2, subfamily a, polypeptide more	84.68(n) 85.43(a)	13087 NM_007812.3 NP_031838.2
fruit fly (Drosophila melanogaster)	Cyp303a1³	35F5	cytochrome P450	27(a) (best of 2)	--
worm (Caenorhabditis elegans)	C50H11.15³	V(3091686-3094310)	cytochrome P450	33(a) (best of 35)	--

About this table Species with no ortholog for CYP2A6

ENSEMBL Gene Tree for CYP2A6

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for CYP2A6 gene

CYP2A7¹ ² CYP2A13¹ ² CYP2S1² CYP2B7P1² CYP2B6²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/201 NCBI SNPs in CYP2A6 are shown (see all 201 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 30)

AB	SNP ID	Valid	Chr 19 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs1801272^1,2	C,F,H	46046373(-)	`CGCCCT/ACCGGG`	1	H/L	mis¹		12		MN CSAM EA EU WA NA	944
--	rs4997557^1,2	C,F,H	46043793(+)	`ACGTGG/CTCATC`	1	S/T	mis¹		8		EU EA WA	824
	rs10418304^1,2	C,F,H	46048591(+)	`AGGGTA/GAGACA`	1	--	ng3¹		4		EU EA WA	414
--	rs2259219^1,2	F,H	46041090(+)	`AGAATC/GTGTCT`	1	--	ng5¹		4		EU EA WA	400
--	rs6413474^1,2	C,F	46041599(-)	`CCCCAA/GACACG`	1	K/R	mis¹		5		MN CSAM EA	404
--	rs5031017^1,2	F,H	46041590(-)	`CGTGGG/TCTTTG`	1	G/V	mis¹		6		MN CSAM EA WA	512
--	rs2545785^1,2	A,H	46048927(+)	`AGGGGA/TGGAAG`	1	--	ng3¹		4		EU EA WA	418
--	rs2644914^1,2	A,O	46049851(+)	`ATTGGC/TGGGTT`	1	--	ng3¹		0	--	--	--	--
--	rs7248240^1,2	A,C	46041480(+)	`AGCCCC/GGTCTT`	1	--	ut3¹		0	--	--	--	--
--	rs5031016^1,2	C,F	46041614(-)	`GGACAT/CTGACG`	1	T/I	mis¹		5		MN CSAM EA	400

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HapMap Linkage Disequilibrium images for CYP2A6 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 122720 disorders: 122700 188890 211980

10/38 Novoseek disease relationships for CYP2A6 gene (see all 38 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tobacco dependence	36.62	2	12818518 (1), 11207029 (1)
cancer lung	35.27	37	15308589 (5), 10441482 (4), 11207029 (4), 17549345 (3) (see all 18)
smoking habit	23.91	10	15534625 (1), 18004205 (1), 18666753 (1), 17934923 (1) (see all 5)
liver damage	17.24	1	11131450 (1)
cancer	17.24	26	11927498 (2), 16176798 (2), 10517986 (2), 1486838 (1) (see all 20)
alcoholic cirrhosis	14.38	1	11131450 (1)
liver diseases	6.73	8	11131450 (3), 9831966 (3), 9453493 (1), 15155834 (1)
renal disease	5.36	5	15531436 (2)
tuberculosis	3.49	2	17073780 (2)
chemically induced	3.17	1	9722582 (1)

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1 PharmGKB disease relationship for CYP2A6 gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Neoplasms	PK	12042667

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Human Gene Mutation Database: CYP2A6
Genetic Association Database: CYP2A6
Human Genome Epidemiology Navigator: CYP2A6 (100 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/537 PubMed articles for CYP2A6 gene (see all 537 ):

Ethnic variation in CYP2A6 and association of genetically slow nicotine metabolism and smoking in adult Caucasians. (PubMed id 15475735)^{3, 6, 7} Schoedel K.A....Tyndale R.F. (2004)
Characterization of a novel CYP2A7/CYP2A6 hybrid allele (CYP2A6*12) that causes reduced CYP2A6 activity. (PubMed id 12325023)^{3, 6, 7} Oscarson M....Ingelman-Sundberg M. (2002)
A novel single nucleotide polymorphism altering stability and activity of CYP2a6. (PubMed id 11237731)^{3, 4, 6} Ariyoshi N.... Kamataki T. (2001)
cDNA and deduced amino acid sequences of human P450 IIA3 (CYP2A3). (PubMed id 2748347)^{2, 3, 4} Yamano S....Gonzalez F.J. (1989)
Variation in coumarin 7-hydroxylase activity associated with genetic polymorphism of cytochrome P450 2A6 and the body status of iron stores in adult Thai males and females. (PubMed id 11927840)^{1, 3, 6} Ujjin P....Kamataki T. (2002)
Frequency of CYP2A6 gene deletion and its relation to risk of lung and esophageal cancer in the Chinese population. (PubMed id 11241319)^{1, 3, 6} Tan W....Lin D.X. (2001)
Novel and established CYP2A6 alleles impair in vivo nicotine metabolism in a population of Black African descent. (PubMed id 18360915)^{1, 3, 4} Mwenifumbo J.C....Tyndale R.F. (2008)
Three haplotypes associated with CYP2A6 phenotypes in Caucasians. (PubMed id 16041240)^{1, 3, 6} Haberl M....Wojnowski L. (2005)
Comparison of cytochrome P450 2A6 polymorphism frequencies in Caucasians and African-Americans using a new one-step PCR-RFLP genotyping method. (PubMed id 11684323)^{1, 3, 6} Paschke T....Bepler G. (2001)
Association of CYP2A6 gene deletion with cigarette smoking status in Japanese adults. (PubMed id 12749606)^{1, 3, 6} Ando M....Ohno Y. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 1548	HGNC: 2610	AceView: CYP2A6andCYP2A7	Ensembl:ENSG00000213052	euGenes: HUgn1548
ECgene: CYP2A6	H-InvDB: CYP2A6

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for CYP2A6	Genetics and Cytogenetics in Oncology and Haematology
Cytochrome P450 Allele Nomenclature Committee	http://www.cypalleles.ki.se/cyp2a6.htm
NIEHS-SNPs	http://egp.gs.washington.edu/data/cyp2a6/
Wikipedia	http://en.wikipedia.org/wiki/CYP2A6

Licensable Technologies for CYP2A6
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for CYP2A6:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for CYP2A6-related products

	Millipore Custom Antibody & Bulk Services
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	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for CYP2A6		Antibodies for CYP2A6
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	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
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Antibodies for CYP2A6

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CYP2A6 Gene

protein-coding GIFtS: 65

Aliases &
Descriptions
for CYP2A6

Summaries
for CYP2A6

Genomic Location
for CYP2A6

Proteins
for CYP2A6

Protein Domains/
Families
for CYP2A6

Gene Function
for CYP2A6

Pathways & Interactions
for CYP2A6

Drugs & Compounds
for CYP2A6

Transcripts
for CYP2A6

Expression
for CYP2A6

Orthologs
for CYP2A6

Paralogs
for CYP2A6

SNPs/Variants
for CYP2A6

Disorders & Mutations
for CYP2A6

Medical News
for CYP2A6

Publications
for CYP2A6

Search for CYP2A6

Genome Databases showing CYP2A6

Other Databases showing CYP2A6

Specialized Databases showing CYP2A6

Licensable Technologies
for CYP2A6

Services
for CYP2A6

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

CYP2A6 Gene

protein-coding GIFtS: 65

Aliases & Descriptionsfor CYP2A6

Summariesfor CYP2A6

Genomic Locationfor CYP2A6

Proteinsfor CYP2A6

Protein Domains/Familiesfor CYP2A6

Gene Functionfor CYP2A6

Pathways & Interactionsfor CYP2A6

Drugs & Compoundsfor CYP2A6

Transcriptsfor CYP2A6

Expression for CYP2A6

Orthologsfor CYP2A6

Paralogsfor CYP2A6

SNPs/Variantsfor CYP2A6

Disorders & Mutationsfor CYP2A6

Medical Newsfor CYP2A6

Publicationsfor CYP2A6

Search for CYP2A6

Genome Databases showing CYP2A6

Other Databases showing CYP2A6

Specialized Databases showing CYP2A6

Licensable Technologiesfor CYP2A6

Servicesfor CYP2A6

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for CYP2A6

Summaries
for CYP2A6

Genomic Location
for CYP2A6

Proteins
for CYP2A6

Protein Domains/
Families
for CYP2A6

Gene Function
for CYP2A6

Pathways & Interactions
for CYP2A6

Drugs & Compounds
for CYP2A6

Transcripts
for CYP2A6

Expression
for CYP2A6

Orthologs
for CYP2A6

Paralogs
for CYP2A6

SNPs/Variants
for CYP2A6

Disorders & Mutations
for CYP2A6

Medical News
for CYP2A6

Publications
for CYP2A6

Licensable Technologies
for CYP2A6

Services
for CYP2A6