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CYP2A13 Gene

protein-coding   GIFtS: 64
GCID: GC19P041594

Cytochrome P450, Family 2, Subfamily A, Polypeptide 13

(Previous names: cytochrome P450, subfamily IIA (phenobarbital-inducible),...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cytochrome P450, Family 2, Subfamily A, Polypeptide 131 2     CPAD2
Cytochrome P450, Subfamily IIA (Phenobarbital-Inducible), Polypeptide 131 2     CYP2A2
CYPIIA132 3     Cytochrome P450 2A132
EC 1.14.14.13 8     

External Ids:    HGNC: 26081   Entrez Gene: 15532   Ensembl: ENSG000001978387   OMIM: 6080555   UniProtKB: Q166963   

Export aliases for CYP2A13 gene to outside databases

Previous GC identifers: GC19P042233 GC19P041986 GC19P046108 GC19P046126 GC19P046130 GC19P046286 GC19P038026


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CYP2A13 Gene:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are
monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids
and other lipids. This protein localizes to the endoplasmic reticulum. Although its endogenous substrate has not
been determined, it is known to metabolize 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, a major nitrosamine
specific to tobacco. This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and
CYP2F subfamilies on chromosome 19q. (provided by RefSeq, Jul 2008)

GeneCards Summary for CYP2A13 Gene:
CYP2A13 (cytochrome P450, family 2, subfamily A, polypeptide 13) is a protein-coding gene. Diseases associated with CYP2A13 include pandas, and intermittent claudication. GO annotations related to this gene include electron carrier activity and heme binding. An important paralog of this gene is CYP2W1.

UniProtKB/Swiss-Prot: CP2AD_HUMAN, Q16696
Function: Exhibits a coumarin 7-hydroxylase activity. Active in the metabolic activation of
hexamethylphosphoramide, N,N-dimethylaniline, 2'-methoxyacetophenone, N-nitrosomethylphenylamine, and the
tobacco-specific carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Possesses phenacetin O-deethylation
activity

Gene Wiki entry for CYP2A13 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NC_018930.2  NT_011109.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the CYP2A13 gene promoter:
         NF-AT2   Sp1   NF-AT3   NF-AT1   NF-AT   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCYP2A13 promoter sequence
   Search Chromatin IP Primers for CYP2A13

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CYP2A13


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.2   Ensembl cytogenetic band:  19q13.2   HGNC cytogenetic band: 19q13.2

CYP2A13 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CYP2A13 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P041594:  view genomic region     (about GC identifiers)

Start:
41,594,368 bp from pter      End:
41,602,100 bp from pter
Size:
7,733 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CP2AD_HUMAN, Q16696 (See protein sequence)
Recommended Name: Cytochrome P450 2A13  
Size: 494 amino acids; 56688 Da
Cofactor: Heme group
Selected PDB 3D structures from and Proteopedia for CYP2A13 (see all 8):
2P85 (3D)        2PG5 (3D)        2PG6 (3D)        2PG7 (3D)        3T3S (3D)        4EJG (3D)    
Secondary accessions: Q53YR8 Q6R569 Q6R570 Q9H2X2

Explore the universe of human proteins at neXtProt for CYP2A13: NX_Q16696

Explore proteomics data for CYP2A13 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for CYP2A13 (Q16696) (see all 28)
     DRAKMPY  GKLPPGP  PGPTPLP  LLLMKHP 


    See CYP2A13 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000757.2  
    ENSEMBL proteins: 
     ENSP00000332679  
    Reactome Protein details: Q16696

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CYP: Cytochrome P450s

    IUPHAR Guide to PHARMACOLOGY protein family classification: CYP2A13
    CYP2 family

    4 InterPro protein domains:
     IPR001128 Cyt_P450
     IPR017972 Cyt_P450_CS
     IPR002401 Cyt_P450_E_grp-I
     IPR008067 Cyt_P450_E_grp-I_CYP2A-like

    Graphical View of Domain Structure for InterPro Entry Q16696

    ProtoNet protein and cluster: Q16696

    2 Blocks protein domains:
    IPB002401 E-class P450 group I signature
    IPB008067 CYP2A P450 family signature


    UniProtKB/Swiss-Prot: CP2AD_HUMAN, Q16696
    Similarity: Belongs to the cytochrome P450 family


    CYP2A13 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CP2AD_HUMAN, Q16696
    Function: Exhibits a coumarin 7-hydroxylase activity. Active in the metabolic activation of
    hexamethylphosphoramide, N,N-dimethylaniline, 2'-methoxyacetophenone, N-nitrosomethylphenylamine, and the
    tobacco-specific carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Possesses phenacetin O-deethylation
    activity
    Catalytic activity: RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O
    Biophysicochemical properties: Kinetic parameters: KM=10.7 uM for phenacetin;

         Genatlas biochemistry entry for CYP2A13:
    cytochrome P450,subfamily IIA (phenobarbital-inducible),polypeptide 13

         Enzyme Number (IUBMB): EC 1.14.14.11 2

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005506iron ion binding IEA--
    GO:0016705oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen ----
    GO:0020037heme binding IDA17428784
    GO:0070330aromatase activity IEA--
         
    CYP2A13 for ontologies           About GeneDecksing


    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CP2AD_HUMAN, Q16696: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral
    membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    extracellular1
    golgi apparatus1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane TAS--

    CYP2A13 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CYP2A13 About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1Biological oxidations
    Biological oxidations0.56
    Acetaminophen metabolism0.00
    metapathway biotransformation0.42
    2Cytochrome P450 - arranged by substrate type
    Cytochrome P450 - arranged by substrate type0.75
    Xenobiotics0.00
    Phase 1 - Functionalization of compounds0.75
    Fatty acids0.00
    cytochrome P4500.74
    CYP2E1 reactions0.00
    3Chemical carcinogenesis
    Metabolism of xenobiotics by cytochrome P4500.71
    Aflatoxin B1 metabolism0.00
    Chemical carcinogenesis0.71
    4Estrone metabolism
    Androstenedione and testosterone biosynthesis and metabolism p.10.57
    5Tryptophan metabolism
    Tryptophan metabolism0.46

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 GeneGo (Thomson Reuters) Pathways for CYP2A13
        Androstenedione and testosterone biosynthesis and metabolism p.1
    Acetaminophen metabolism

    4 BioSystems Pathways for CYP2A13
        Aflatoxin B1 metabolism
    cytochrome P450
    metapathway biotransformation
    Tryptophan metabolism

    3 Reactome Pathways for CYP2A13
        Fatty acids
    Xenobiotics
    CYP2E1 reactions

    1 PharmGKB Pathway for CYP2A13
        Nicotine Pathway, Pharmacokinetics

    2 Kegg Pathways  (Kegg details for CYP2A13):
        Metabolism of xenobiotics by cytochrome P450
    Chemical carcinogenesis


    CYP2A13 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including CYP2A13: 
              Drug Metabolism: Phase I Enzymes in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for CYP2A13

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CYP2A13 (ENSP000003326794) via UniProtKB, MINT, STRING, and/or I2D (see all 43)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ALDH1A1ENSP000002977854STRING: ENSP00000297785
    CYP1A1ENSP000003690504STRING: ENSP00000369050
    CYP1A2ENSP000003420074STRING: ENSP00000342007
    CYP26A1ENSP000002243564STRING: ENSP00000224356
    CYP26B1ENSP000000011464STRING: ENSP00000001146
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006805xenobiotic metabolic process TAS--
    GO:0044281small molecule metabolic process TAS--
    GO:0055114oxidation-reduction process ----

    CYP2A13 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CYP2A13 (CP2AD)

    Selected HMDB Compounds for CYP2A13 (see all 50)    About this table
    CompoundSynonyms CAS #PubMed Ids
    10-HETE10-hydroxyeicosa-all-cis-5,8,11,14-tetraenoate (see all 2)167697-52-1--
    11,12,15-THETA11,12,15-Trihydroxyicosatrienoic acid (see all 5)----
    11,12-Epoxyeicosatrienoic acid10-(3-(2-octenyl)oxiranyl)-5,8-Decadienoic acid (see all 15)81276-02-0--
    11,14,15-THETA(5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoic acid (see all 8)----
    11H-14,15-EETA14,15-Ep-11-HETrE (see all 11)219535-29-2--
    11beta-Hydroxytestosterone11beta,17beta-dihydroxyandrost-4-en-3-one 1816-85-9--
    12,13-EpOMEVernolic acid (see all 12)----
    13-HETE13-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoate (see all 2)151910-72-4--
    14,15-Epoxy-5,8,11-eicosatrienoic acid(5Z,8Z,11Z)-14,15-Epoxyicosa-5.8.11-trienoic acid (see all 11)81276-03-1--
    15(S)-HPETE(5Z,8Z,11Z,13E)-(15S)-15-Hydroperoxyicosa-5,8,11,13-tetraenoate (see all 8)70981-96-3--

    4 DrugBank Compounds for CYP2A13    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    MethoxsalenMethoxalen (see all 5)298-81-7enzymeinhibitor19934256
    NicotineL-Nicotine (see all 2)54-11-5enzymesubstrate19934256
    PhenacetinAcetophenetidin (see all 4)62-44-2enzymesubstrate19934256
    TestosteroneTES (see all 9)58-22-0enzymesubstrate19934256

    6 Novoseek inferred chemical compound relationships for CYP2A13 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone 93.2 18 17671098 (2), 17717079 (2), 14633739 (1), 15115698 (1) (see all 13)
    coumarin 77.6 15 15196988 (4), 19251817 (3), 17922361 (2), 11016631 (1)
    8 methoxypsoralen 74.8 8 18813816 (2), 17671098 (1), 15579482 (1)
    aflatoxin b1 63 16 16385575 (4), 16815959 (2), 16917071 (2), 17178771 (1) (see all 5)
    nicotine 62 9 15528319 (4), 19434638 (1), 16135656 (1), 18779312 (1)
    cotinine 49.3 4 15528319 (3), 18779312 (1)



    CYP2A13 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CYP2A13 gene: 
    NM_000766.4  

    Unigene Cluster for CYP2A13:

    Cytochrome P450, family 2, subfamily A, polypeptide 13
    Hs.567252
    Unigene Representative Sequence: NM_000766
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000330436(uc002opt.3)
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    Additional mRNA sequence: 

    AF209774.1 AY513604.1 AY513605.1 AY513606.1 AY513607.1 AY513608.1 AY513609.1 

    2 DOTS entries:

    DT.102820753  DT.121503364 

    11 AceView cDNA sequences:

    AY513606 AF209774 AY513609 NM_000766 AY513608 AY513605 AY513604 AY513607 
    BM975825 CD609500 CD609501 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CYP2A13 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CYP2A13 Expression
    About this image

    CYP2A13 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CYP2A13 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.567252

    UniProtKB/Swiss-Prot: CP2AD_HUMAN, Q16696
    Tissue specificity: Expressed in liver and a number of extrahepatic tissues, including nasal mucosa, lung,
    trachea, brain, mammary gland, prostate, testis, and uterus, but not in heart, kidney, bone marrow, colon, small
    intestine, spleen, stomach, thymus, or skeletal muscle

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CYP2A13 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cyp2a45
    Cyp2a51
    cytochrome P450, family 2, subfamily a, polypeptide 4 less5
    cytochrome P450, family 2, subfamily a, polypeptide 5 less1
    85.49(n)1
    88.46(a)1
      7 (14.39 cM)5
    130871  NM_007812.41  NP_031838.21 
     263071925 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 6)
    Uncharacterized protein
    (see all 6)
    60(a)
    60(a)
    (see all 6)
    many ↔ many
    many ↔ many
    (see all 6)
    AAWZ02038417(567-11161)
    GL344734.1(1715-22858)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.432 Xenopus laevis mRNA for cytochrome P-450, complete cds less 74.27(n)    D50560.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc558562 hypothetical protein MGC55856 73.45(n)   393204  BC046898.1 
    worm
    (Caenorhabditis elegans)
    Secernentea C50H11.153
    cyp-36A11
    cytochrome P4503
    cyp-36A11
    34(a)
    (best of 35)3
    43.1(n)1
    33.7(a)1
      V(3091686-3094310)3
    1831931  NM_059866.41  NP_492267.11 


    ENSEMBL Gene Tree for CYP2A13 (if available)
    TreeFam Gene Tree for CYP2A13 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CYP2A13 gene
    CYP2A61 2  CYP2A71 2  CYP2W12  CYP2C82  CYP2F12  CYP2B62  CYP2C192  CYP2R12  
    CYP2J22  CYP2U12  CYP2S12  CYP2E12  CYP2C92  CYP2D62  CYP2C182  
    Selected SIMAP similar genes for CYP2A13 using alignment to 1 protein entry:     CP2AD_HUMAN(see all similar genes):
    CYP2A6    CYP2A6V2    CYP2A7    CYP2B    CYP2B7    CYP2C19
    CYP2F1    CYP2C18    CYP2C8    CYP2C9    CYP 2C    CYP2E1
    CYP2S1    CYP2J2    CYP2R1    CYP2B6    CYP2U1    CYP2D6

    CYP2A13 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    CP2AD_HUMAN, Q16696: The frequencies of the Cys-257 allele in white, black, Hispanic, and Asian individuals are 1.9%,
    14.4%, 5.8%, and 7.7%, respectively. The Cys-257 variant is 37 to 56% less active than the wild-type Arg-257
    protein toward all substrates tested


    Selected SNPs for CYP2A13 (see all 432)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs24537921,2
    C,F,A--38024545(-) GGGCTG/CTGACA 1 -- us2k15Minor allele frequency- C:0.40NA WA 10
    rs24537911,2
    C,F,A,H--38024590(-) AGGGCA/GTAAGG 1 -- us2k14Minor allele frequency- G:0.38NA 8
    rs1511565091,2
    C--41779855(+) CTCATC/GTCAGA 1 -- us2k10--------
    rs1390158861,2
    C--41779941(+) GGTGC-/CACTCTTATGCC
    CTCCTGAAGCAGGA
    CTCTC
    1 -- us2k10--------
    rs1432923741,2
    C--41780113(+) AACACA/GATGCC 1 -- us2k10--------
    rs1841786541,2
    --41780137(+) ACACAC/TCTGAT 1 -- us2k10--------
    rs1471249681,2
    C--41780196(+) CAGTCC/TCAGCA 1 -- us2k10--------
    rs1886366101,2
    --41780214(+) CCTGCC/TAAGCC 1 -- us2k10--------
    rs1385501261,2
    C--41780217(+) GCTAAG/TCCTGG 1 -- us2k10--------
    rs3059891,2
    C,F,A,H--41780376(+) GATCAC/TGATGA 1 -- us2k12Minor allele frequency- T:0.50NA WA 4

    HapMap Linkage Disequilibrium report for CYP2A13 (41594368 - 41602100 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CYP2A13:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv2491CNV Loss18451855

    The Human Cytochrome P450 Allele Nomenclature Database: CYP2A13 
    Human Gene Mutation Database (HGMD): CYP2A13
    Locus Specific Mutation Databases (LSDB): CYP2A13

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CYP2A13
    DNA2.0 Custom Variant and Variant Library Synthesis for CYP2A13

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608055    OMIM disorders: --

    12 diseases for CYP2A13:    
    About MalaCards
    pandas    intermittent claudication    lung cancer susceptibility    lung adenocarcinoma
    leiomyoma    nasopharyngitis    lung cancer    adenocarcinoma
    squamous cell carcinoma    pancreatic cancer    pancreatitis    prostatitis


    CYP2A13 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for CYP2A13 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer lung 48.4 12 16815959 (3), 14633739 (2), 17671098 (1), 17148654 (1) (see all 8)
    cancer 0 1 14633739 (1)

    Genetic Association Database (GAD): CYP2A13
    Human Genome Epidemiology (HuGE) Navigator: CYP2A13 (20 documents)

    Export disorders for CYP2A13 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CYP2A13 gene, integrated from 10 sources (see all 81):
    (articles sorted by number of sources associating them with CYP2A13)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genetic polymorphism of the human cytochrome CYP2A13 in a French population: implication in lung cancer susceptibility. (PubMed id 15063809)1, 2, 4, 9 Cauffiez C.... Broly F. (Biochem. Biophys. Res. Commun. 2004)
    2. A genetic polymorphism in coumarin 7-hydroxylation: sequence of the human CYP2A genes and identification of variant CYP2A6 alleles. (PubMed id 7668294)1, 2, 3, 9 Fernandez-Salguero P.... Idle J.R. (Am. J. Hum. Genet. 1995)
    3. Genetic polymorphisms of the human CYP2A13 gene: identification of single-nucleotide polymorphisms and functional characterization of an Arg257Cys variant. (PubMed id 12130698)1, 2, 4 Zhang X.... Ding X. (J. Pharmacol. Exp. Ther. 2002)
    4. Substantial reduction in risk of lung adenocarcinoma associated with genetic polymorphism in CYP2A13, the most active cytochrome P450 for the metabolic activation of tobacco-specific carcinogen NNK. (PubMed id 14633739)1, 4, 9 Wang H....Lin D. (Cancer Res. 2003)
    5. Human cytochrome P450 CYP2A13: predominant expression in the respiratory tract and its high efficiency metabolic activation of a tobacco-specific carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1- butanone. (PubMed id 11016631)1, 2, 9 Su T.... Ding X. (Cancer Res. 2000)
    6. Eighteen novel polymorphisms of the CYP2A13 gene in Japanese. (PubMed id 15618722)1, 2, 9 Fujieda M.... Kamataki T. (Drug Metab. Pharmacokinet. 2003)
    7. Structure of the human lung cytochrome P450 2A13. (PubMed id 17428784)1, 2, 9 Smith B.D....Scott E.E. (J. Biol. Chem. 2007)
    8. CYP2A13 genetic polymorphism in French Caucasian, Gabonese and Tunisian populations. (PubMed id 16316926)1, 4, 9 Cauffiez C....Broly F. ( the fate of foreign compounds in biological systems 2005)
    9. CYP2A13, ADH1B, and ADH1C gene polymorphisms and pancreatic cancer risk. (PubMed id 19812523)1, 4, 9 Mohelnikova-Duchonova B....Soucek P. (Pancreas 2010)
    10. CYP450 polymorphisms as risk factors for early-onset lung cancer: gender-specific differences. (PubMed id 19414505)1, 4, 9 Timofeeva M.N....Wichmann H.E. (Carcinogenesis 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1553 HGNC: 2608 AceView: CYP2A13 Ensembl:ENSG00000197838 euGenes: HUgn1553
    ECgene: CYP2A13 Kegg: 1553 H-InvDB: CYP2A13

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CYP2A13 Pharmacogenomics, SNPs, Pathways
    Cytochrome P450 Allele Nomenclature Committeehttp://www.cypalleles.ki.se/cyp2a13.htm

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CYP2A13 gene:
    Search GeneIP for patents involving CYP2A13

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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