CYP2A13 Gene
protein-coding GIFtS: 62
GCID: GC19P041594
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|
cytochrome P450, family 2, subfamily A, polypeptide 13(Previous names: cytochrome P450, subfamily IIA (phenobarbital-inducible),...)
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Aliases
for CYP2A13 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Cytochrome P450, Family 2, Subfamily A, Polypeptide 131 2 | | CYPIIA132 3 | | CPAD1 2 | | EC 1.14.14.13 8 | | CYP2A1 2 | | Cytochrome P450 2A132 | | Cytochrome P450, Subfamily IIA (Phenobarbital-Inducible), Polypeptide 131 2 | | |
Export aliases for CYP2A13 gene to outside databasesPrevious GC identifers: GC19P042233 GC19P041986 GC19P046108 GC19P046126 GC19P046130 GC19P046286 GC19P038026 |
Summaries
for CYP2A13 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CYP2A13:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins aremonooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids andother lipids. This protein localizes to the endoplasmic reticulum. Although its endogenous substrate has not beendetermined, it is known to metabolize 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, a major nitrosamine specific totobacco. This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies onchromosome 19q. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: CP2AD_HUMAN, Q16696Function: Exhibits a coumarin 7-hydroxylase activity. Active in the metabolic activation of hexamethylphosphoramide,N,N-dimethylaniline, 2'-methoxyacetophenone, N-nitrosomethylphenylamine, and the tobacco-specific carcinogen,4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Possesses phenacetin O-deethylation activity
Gene Wiki entry for CYP2A13
|
Genomic Views
for CYP2A13 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CYP2A13 gene promoter:
NF-AT2 Sp1 NF-AT3 NF-AT1 NF-AT C/EBPalpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for CYP2A13
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CYP2A13 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.2 Ensembl cytogenetic band: 19q13.2 HGNC cytogenetic band: 19q13.2CYP2A13 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P041594: view genomic region
(about GC identifiers)
Start:
|
41,594,368 bp from pter |
End:
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41,602,099 bp from pter |
Size:
|
7,732 bases |
Orientation:
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plus strand |
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Proteins
for CYP2A13 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CP2AD_HUMAN, Q16696 (See
protein sequence)Recommended Name: Cytochrome P450 2A13 Size: 494 amino acids; 56688 Da
Cofactor: Heme group
Subcellular location: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheralmembrane protein
6/8 PDB 3D structures from  and Proteopedia  for CYP2A13 (see all 8):2P85 (3D)
2PG5 (3D)
2PG6 (3D)
2PG7 (3D)
3T3S (3D)
4EJG (3D)
Secondary accessions: Q53YR8 Q6R569 Q6R570 Q9H2X2Explore the universe of human proteins at neXtProt for CYP2A13: NX_Q16696
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q16696
4/28 DME Specific Peptides for CYP2A13 (Q16696) (see all 28)
CYP2A13 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_000757.2
ENSEMBL proteins: ENSP00000332679 Reactome Protein details: Q16696
Human Recombinant Protein Products for CYP2A13:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005789 | endoplasmic reticulum membrane |
TAS | -- | | GO:0005792 | microsome |
-- | -- |
CYP2A13 for ontologies About GeneDecksing
CYP2A13 Antibody Products:
Assay Products for CYP2A13: |
Protein
Domains /
Families
for CYP2A13 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CYP2A13 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q16696ProtoNet protein and cluster: Q16696 2 Blocks protein families: IPB002401 E-class P450 group I signature IPB008067 CYP2A P450 family signature
UniProtKB/Swiss-Prot: CP2AD_HUMAN, Q16696Similarity: Belongs to the cytochrome P450 family |
Function
for CYP2A13 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: CP2AD_HUMAN, Q16696Function: Exhibits a coumarin 7-hydroxylase activity. Active in the metabolic activation of hexamethylphosphoramide,N,N-dimethylaniline, 2'-methoxyacetophenone, N-nitrosomethylphenylamine, and the tobacco-specific carcinogen,4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Possesses phenacetin O-deethylation activityCatalytic activity: RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)OBiophysicochemical properties: Kinetic parameters: KM=10.7 uM for phenacetin; Genatlas biochemistry entry for CYP2A13:cytochrome P450,subfamily IIA (phenobarbital-inducible),polypeptide 13
Enzyme Number (IUBMB): EC 1.14.14.11 2
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
CYP2A13 for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CYP2A13 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CYP2A13
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: CYP2A13 (NM_000766) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CYP2A13 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CYP2A13 |
|
Pathways & Interactions
for CYP2A13 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/12 super-pathways (see all 12) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Cytochrome P450 - arranged by substrate type | | | 2 | Xenobiotics | | | 3 | Metabolism | | | 4 | Drug metabolism - cytochrome P450 | | | 5 | Biological oxidations | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 EMD Millipore Pathways for CYP2A13
2  GeneGo (Thomson Reuters) Pathways for CYP2A13
4  BioSystems Pathways for CYP2A13
5/6 
Reactome Pathways for CYP2A13 (see all 6)
1  PharmGKB Pathway for CYP2A13
5 
Kegg Pathways (Kegg details for CYP2A13):
CYP2A13 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CYP2A13
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/43 Interacting proteins for CYP2A13 (ENSP000003326794) via UniProtKB, MINT, STRING, and/or I2D (see all 43)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006805 | xenobiotic metabolic process |
TAS | -- | | GO:0044281 | small molecule metabolic process |
TAS | -- |
CYP2A13 for ontologies About GeneDecksing
|
Drugs & Compounds
for CYP2A13 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
CYP2A13 for compounds About GeneDecksing
 Browse Tocris compounds for CYP2A13
10/50 HMDB Compounds for CYP2A13 (see all 50) About this table
| Compound | Synonyms |
CAS
# | PubMed Ids |
|---|
| 10-HETE | 10-hydroxyeicosa-all-cis-5,8,11,14-tetraenoate (see all 2) | 167697-52-1 | -- | | 11,12,15-THETA | 11,12,15-Trihydroxyicosatrienoic acid (see all 5) | -- | -- | | 11,12-Epoxyeicosatrienoic acid | 10-(3-(2-octenyl)oxiranyl)-5,8-Decadienoic acid (see all 15) | 81276-02-0 | -- | | 11,14,15-THETA | (5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoic acid (see all 8) | -- | -- | | 11H-14,15-EETA | 14,15-Ep-11-HETrE (see all 11) | 219535-29-2 | -- | | 11beta-Hydroxytestosterone | 11beta,17beta-dihydroxyandrost-4-en-3-one | 1816-85-9 | -- | | 12,13-EpOME | Vernolic acid (see all 12) | -- | -- | | 13-HETE | 13-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoate (see all 2) | 151910-72-4 | -- | | 14,15-Epoxy-5,8,11-eicosatrienoic acid | (5Z,8Z,11Z)-14,15-Epoxyicosa-5.8.11-trienoic acid (see all 11) | 81276-03-1 | -- | | 15(S)-HPETE | (5Z,8Z,11Z,13E)-(15S)-15-Hydroperoxyicosa-5,8,11,13-tetraenoate (see all 8) | 70981-96-3 | -- |
4 DrugBank Compounds for CYP2A13 About this table
6 Novoseek chemical compound relationships for CYP2A13 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone |
93.2 |
18 |
17671098 (2), 17717079 (2), 14633739 (1), 15115698 (1) (see all 13) |
| coumarin |
77.6 |
15 |
15196988 (4), 19251817 (3), 17922361 (2), 11016631 (1) |
| 8 methoxypsoralen |
74.8 |
8 |
18813816 (2), 17671098 (1), 15579482 (1) |
| aflatoxin b1 |
63 |
16 |
16385575 (4), 16815959 (2), 16917071 (2), 17178771 (1) (see all 5) |
| nicotine |
62 |
9 |
15528319 (4), 19434638 (1), 16135656 (1), 18779312 (1) |
| cotinine |
49.3 |
4 |
15528319 (3), 18779312 (1) |
Search CenterWatch for drugs/clinical trials and news about CYP2A13 / CP2AD
|
Transcripts
for CYP2A13 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CYP2A13 gene: NM_000766.4 Unigene Cluster for CYP2A13: Cytochrome P450, family 2, subfamily A, polypeptide 13 Hs.567252 Unigene Representative Sequence: NM_0007661 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000330436(uc002opt.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CYP2A13 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CYP2A13
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CYP2A13 (NM_000766) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CYP2A13 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CYP2A13 |
Additional cDNA sequence: AF209774.1 AY513604.1 AY513605.1 AY513606.1 AY513607.1 AY513608.1 AY513609.1 2 DOTS entries: DT.102820753 DT.121503364 11 AceView cDNA sequences: AY513608 AY513609 AY513605 AY513606 NM_000766 AF209774 AY513604 AY513607 BM975825 CD609500 CD609501
GeneLoc Exon Structure
|
Expression
for CYP2A13 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CYP2A13 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See CYP2A13 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CYP2A13
SOURCE GeneReport for Unigene cluster: Hs.567252
UniProtKB/Swiss-Prot: CP2AD_HUMAN, Q16696Tissue specificity: Expressed in liver and a number of extrahepatic tissues, including nasal mucosa, lung, trachea,brain, mammary gland, prostate, testis, and uterus, but not in heart, kidney, bone marrow, colon, small intestine,spleen, stomach, thymus, or skeletal muscle
SABiosciences Expression via Pathway-Focused PCR Array including CYP2A13:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CYP2A13
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CYP2A13 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CYP2A13 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CYP2A13 |
Orthologs
for CYP2A13 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for CYP2A13 gene from 3/13 species (see all 13) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
----(see all 4) |
-- |
54(a)51(a)(see all 4) |
possible orthologpossible ortholog(see all 4) |
LGf(2965993-2976553) LGf(2923593-2936165) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.432 |
Xenopus laevis mRNA for cytochrome P-450, complete more |
74.27(n) |
|
D50560.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
zgc558562 |
hypothetical protein MGC55856 |
73.45(n) |
|
393204 BC046898.1 |
ENSEMBL Gene Tree for CYP2A13 (if available)
TreeFam Gene Tree for CYP2A13 (if available) |
Paralogs
for CYP2A13 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CYP2A13 gene
- CYP2W12 CYP2C82 CYP2F12 CYP2A72 CYP2R12 CYP2J22 CYP2U12 CYP2E12
- CYP2D62 CYP2B7P12 CYP2A62 CYP2B62 CYP2C192 CYP2S12 CYP2C92 CYP2C182
18/25 SIMAP similar genes for CYP2A13 using alignment to 1 protein entry: CP2AD_HUMAN(see all similar genes):CYP2A6 CYP2A6V2 CYP2A7 CYP2B CYP2B7 CYP2C19
CYP2F1 CYP2C18 CYP2C8 CYP2C9 CYP 2C CYP2S1
CYP2E1 CYP2B6 CYP2J2 CYP2R1 CYP2U1 CYP2D6
CYP2A13 for paralogs About GeneDecksing
|
Genomic Variants
for CYP2A13 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
UniProtKB/Swiss-Prot: CP2AD_HUMAN, Q16696Polymorphism: The frequencies of the Cys-257 allele in white, black, Hispanic, and Asian individuals are 1.9%, 14.4%,5.8%, and 7.7%, respectively. The Cys-257 variant is 37 to 56% less active than the wild-type Arg-257 protein towardall substrates tested
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CYP2A13 (41594368 - 41602099 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CYP2A13: --
Human Gene Mutation Database (HGMD): CYP2A13
Locus Specific Mutation Databases (LSDB): CYP2A13
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CYP2A13 |
|
Disorders
/ Diseases
for CYP2A13 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CYP2A13 for disorders About GeneDecksing
OMIM gene information: 608055
OMIM disorders: --
12  diseases for CYP2A13: About MalaCardsintermittent claudication cholesterol squamous cell carcinoma lung cancer susceptibility
pandas lung cancer lung adenocarcinoma leiomyoma
nasopharyngitis adenocarcinoma carcinoma prostatitis
2 Novoseek disease relationships for CYP2A13 gene About this table
Genetic Association Database (GAD): CYP2A13
Human Genome Epidemiology (HuGE) Navigator: CYP2A13 (20 documents)
Export disorders for CYP2A13 gene to outside databases
|
Publications
for CYP2A13 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CYP2A13 gene, integrated from 9 sources (see all 74):
(articles sorted by number of sources associating them with CYP2A13) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Genetic polymorphism of the human cytochrome CYP2A13 in a French population: implication in lung cancer susceptibility. (PubMed id 15063809)1, 2, 4, 9 Cauffiez C.... Broly F. (2004)
- A genetic polymorphism in coumarin 7-hydroxylation: sequence of the human CYP2A genes and identification of variant CYP2A6 alleles. (PubMed id 7668294)1, 2, 3, 9 Fernandez-Salguero P.... Idle J.R. (1995)
- Genetic polymorphisms of the human CYP2A13 gene: identification of single-nucleotide polymorphisms and functional characterization of an Arg257Cys variant. (PubMed id 12130698)1, 2, 4 Zhang X.... Ding X. (2002)
- Substantial reduction in risk of lung adenocarcinoma associated with genetic polymorphism in CYP2A13, the most active cytochrome P450 for the metabolic activation of tobacco-specific carcinogen NNK. (PubMed id 14633739)1, 4, 9 Wang H....Lin D. (2003)
- Human cytochrome P450 CYP2A13: predominant expression in the respiratory tract and its high efficiency metabolic activation of a tobacco-specific carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1- butanone. (PubMed id 11016631)1, 2, 9 Su T.... Ding X. (2000)
- Eighteen novel polymorphisms of the CYP2A13 gene in Japanese. (PubMed id 15618722)1, 2, 9 Fujieda M.... Kamataki T. (2003)
- Structure of the human lung cytochrome P450 2A13. (PubMed id 17428784)1, 2, 9 Smith B.D....Scott E.E. (2007)
- CYP2A13 genetic polymorphism in French Caucasian, Gabonese and Tunisian populations. (PubMed id 16316926)1, 4, 9 Cauffiez C....Broly F. (2005)
- Arg257Cys polymorphism of CYP2A13 in a Chinese population. (PubMed id 15115698)1, 4, 9 Cheng X.Y....Zhou H.H. (2004)
- Single nucleotide polymorphisms of the human cyp2a13 gene: evidence for a null allele. (PubMed id 12920161)1, 4, 9 Zhang X....Ding X. (2003)
|
External Searches for CYP2A13 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CYP2A13 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CYP2A13 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CYP2A13 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
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| Name | Description |
| PharmGKB entry for CYP2A13 | Pharmacogenomics, SNPs, Pathways | | Cytochrome P450 Allele Nomenclature Committee | http://www.cypalleles.ki.se/cyp2a13.htm |
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About This Section
| Patent Information for CYP2A13 gene:
Search GeneIP for patents involving CYP2A13
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for CYP2A13 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CYP2A13 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CYP2A13 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CYP2A13 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CYP2A13 | | OriGene 3'-UTR Clone for CYP2A13 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CYP2A13 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CYP2A13 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CYP2A13 | | OriGene Custom Protein Services for CYP2A13 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CYP2A13 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CYP2A13 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CYP2A13 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CYP2A13 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CYP2A13 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CYP2A13 |
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| | | | Search Tocris compounds for CYP2A13 |
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 | | | CYP2A13 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  |  | | | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CYP2A13 |
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