CYP27C1 Gene
protein-coding GIFtS: 47
GCID: GC02M127941
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cytochrome P450, family 27, subfamily C, polypeptide 1
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Aliases
for CYP27C1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Cytochrome P450, Family 27, Subfamily C, Polypeptide 11 2 | | FLJ160081 | | Cytochrome P450 27C12 | | Cytochrome P450, Family 27, Subfamily C, Polypeptide 132 | | EC 1.14.-.-3 |
Export aliases for CYP27C1 gene to outside databasesPrevious GC identifers: GC02M127658 GC02M120248 |
Summaries
for CYP27C1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CYP27C1:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins aremonooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids andother lipids. (provided by RefSeq, Jul 2008)
Gene Wiki entry for CYP27C1
|
Genomic Views
for CYP27C1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_022135.16
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for CYP27C1
Other transcription factors
Search SABiosciences Chromatin IP Primers for CYP27C1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CYP27C1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2q14.3 Ensembl cytogenetic band: 2q14.3 HGNC cytogenetic band: 2q14.3CYP27C1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02M127941: view genomic region
(about GC identifiers)
Start:
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127,941,412 bp from pter |
End:
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127,977,654 bp from pter |
Size:
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36,243 bases |
Orientation:
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minus strand |
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Proteins
for CYP27C1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: C27C1_HUMAN, Q4G0S4 (See
protein sequence)Recommended Name: Cytochrome P450 27C1 Size: 372 amino acids; 42632 Da
Cofactor: Heme group (By similarity)
Subcellular location: Membrane (Potential)
Secondary accessions: Q6ZNI7Explore the universe of human proteins at neXtProt for CYP27C1: NX_Q4G0S4
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q4G0S4
CYP27C1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001001665.3
ENSEMBL proteins: ENSP00000334128 ENSP00000387198
Human Recombinant Protein Products for CYP27C1:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016020 | membrane |
IEA | -- |
CYP27C1 for ontologies About GeneDecksing
CYP27C1 Antibody Products:
Assay Products for CYP27C1: |
Protein
Domains /
Families
for CYP27C1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CYP27C1 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q4G0S4ProtoNet protein and cluster: Q4G0S4 UniProtKB/Swiss-Prot: C27C1_HUMAN, Q4G0S4Similarity: Belongs to the cytochrome P450 family |
Function
for CYP27C1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Enzyme Number (IUBMB): EC 1.14.-.-1
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004497 | monooxygenase activity |
IEA | -- | | GO:0005506 | iron ion binding |
IEA | -- | | GO:0009055 | electron carrier activity |
IEA | -- | | GO:0016705 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
IEA | -- | | GO:0020037 | heme binding |
IEA | -- |
CYP27C1 for ontologies About GeneDecksing
Animal Models:
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CYP27C1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYP27C1 |
|
Pathways & Interactions
for CYP27C1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Cytochrome P450 - arranged by substrate type | | | 2 | Biological oxidations | |
2  BioSystems Pathways for CYP27C1
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CYP27C1
|
Drugs & Compounds
for CYP27C1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CYP27C1
1 HMDB Compound for CYP27C1 About this table
| Compound | Synonyms |
CAS
# | PubMed Ids |
|---|
| Heme | (protoporphyrinato)iron (see all 19) | 14875-96-8 | -- |
Search CenterWatch for drugs/clinical trials and news about CYP27C1 / C27C1
|
Transcripts
for CYP27C1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CYP27C1 gene: NM_001001665.3 Unigene Cluster for CYP27C1: Cytochrome P450, family 27, subfamily C, polypeptide 1 Hs.407639 [show with all ESTs]Unigene Representative Sequence: BC0393072 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000335247(uc002tod.2 uc021vnn.1) ENST00000409327
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CYP27C1
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CYP27C1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CYP27C1 (NM_001001665) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CYP27C1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CYP27C1 |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CYP27C1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat CYP27C1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CYP27C1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CYP27C1 |
Additional cDNA sequence: AK131190.1 BC039307.1 2 DOTS entries: DT.91720197 DT.97797836 8 AceView cDNA sequences: BM562765 AA423992 BC039307 NM_001001665 AK131190 BI459427 BQ277249 BX478822
GeneLoc Exon Structure
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Expression
for CYP27C1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CYP27C1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACATTATGCT
About this image
See CYP27C1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CYP27C1
SOURCE GeneReport for Unigene cluster: Hs.407639
SABiosciences Custom PCR Arrays for CYP27C1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CYP27C1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat CYP27C1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CYP27C1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CYP27C1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYP27C1 |
Orthologs
for CYP27C1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for CYP27C1 gene from 6/18 species (see all 18) About this table
ENSEMBL Gene Tree for CYP27C1 (if available)
TreeFam Gene Tree for CYP27C1 (if available) |
Paralogs
for CYP27C1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CYP27C1 gene
- CYP11A12 CYP27A12 CYP11B12 CYP24A12 CYP11B22 CYP27B12
7 SIMAP similar genes for CYP27C1 using alignment to 1 protein entry: C27C1_HUMAN:CYP27A1 CYP27B1 CYP3A5 CYP24 CYP24A1 CYP11B2
CYP11B1
CYP27C1 for paralogs About GeneDecksing
|
Genomic Variants
for CYP27C1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CYP27C1 (127941412 - 127977654 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for CYP27C1
1 CNV: 3391 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CYP27C1 |
|
Disorders
/ Diseases
for CYP27C1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CYP27C1 for disorders About GeneDecksing
2  diseases for CYP27C1: About MalaCardsosteonecrosis cholesterol
1 disease from the University of Copenhagen DISEASES database for CYP27C1:Osteonecrosis Export disorders for CYP27C1 gene to outside databases
|
Publications
for CYP27C1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CYP27C1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with CYP27C1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- A genome-wide association study of self-rated health. (PubMed id 20707712)1 Mosing M.A....Martin N.G. (2010)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
- Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants. (PubMed id 15128046)1 Nelson D.R....Nebert D.W. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for CYP27C1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CYP27C1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CYP27C1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CYP27C1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CYP27C1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CYP27C1 gene:
Search GeneIP for patents involving CYP27C1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CYP27C1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CYP27C1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CYP27C1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CYP27C1 | | | OriGene Protein Over-expression Lysate for CYP27C1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CYP27C1 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CYP27C1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CYP27C1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for CYP27C1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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 |  |  |  | |
| | | | Search Tocris compounds for CYP27C1 |
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 | | | CYP27C1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYP27C1 |
|  |  |  |  | | | | ThermoFisher Antibodies for CYP27C1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CYP27C1 |
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