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Aliases for CYP27C1 Gene

Aliases for CYP27C1 Gene

  • Cytochrome P450 Family 27 Subfamily C Member 1 2 3 5
  • Cytochrome P450, Family 27, Subfamily C, Polypeptide 1 2
  • EC 1.14.-.- 4

External Ids for CYP27C1 Gene

Previous GeneCards Identifiers for CYP27C1 Gene

  • GC02M127658
  • GC02M127941
  • GC02M120248

Summaries for CYP27C1 Gene

Entrez Gene Summary for CYP27C1 Gene

  • This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. [provided by RefSeq, Jul 2008]

GeneCards Summary for CYP27C1 Gene

CYP27C1 (Cytochrome P450 Family 27 Subfamily C Member 1) is a Protein Coding gene. Among its related pathways are cytochrome P450 and Phase II conjugation. GO annotations related to this gene include iron ion binding and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen. An important paralog of this gene is CYP11B1.

Gene Wiki entry for CYP27C1 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYP27C1 Gene

Genomics for CYP27C1 Gene

Regulatory Elements for CYP27C1 Gene

Enhancers for CYP27C1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CYP27C1 on UCSC Golden Path with GeneCards custom track

Genomic Location for CYP27C1 Gene

Chromosome:
2
Start:
127,183,832 bp from pter
End:
127,226,356 bp from pter
Size:
42,525 bases
Orientation:
Minus strand

Genomic View for CYP27C1 Gene

Genes around CYP27C1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CYP27C1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CYP27C1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYP27C1 Gene

Proteins for CYP27C1 Gene

  • Protein details for CYP27C1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q4G0S4-C27C1_HUMAN
    Recommended name:
    Cytochrome P450 27C1
    Protein Accession:
    Q4G0S4
    Secondary Accessions:
    • Q6ZNI7

    Protein attributes for CYP27C1 Gene

    Size:
    372 amino acids
    Molecular mass:
    42632 Da
    Cofactor:
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Quaternary structure:
    No Data Available

neXtProt entry for CYP27C1 Gene

Proteomics data for CYP27C1 Gene at MOPED

Post-translational modifications for CYP27C1 Gene

  • Ubiquitination at Lys 128
  • Modification sites at PhosphoSitePlus

Other Protein References for CYP27C1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CYP27C1 Gene

Domains & Families for CYP27C1 Gene

Gene Families for CYP27C1 Gene

Protein Domains for CYP27C1 Gene

Suggested Antigen Peptide Sequences for CYP27C1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q4G0S4

UniProtKB/Swiss-Prot:

C27C1_HUMAN :
  • Belongs to the cytochrome P450 family.
Family:
  • Belongs to the cytochrome P450 family.
genes like me logo Genes that share domains with CYP27C1: view

Function for CYP27C1 Gene

Enzyme Numbers (IUBMB) for CYP27C1 Gene

Gene Ontology (GO) - Molecular Function for CYP27C1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004497 monooxygenase activity IEA --
GO:0020037 heme binding IEA --
genes like me logo Genes that share ontologies with CYP27C1: view
genes like me logo Genes that share phenotypes with CYP27C1: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CYP27C1 Gene

Localization for CYP27C1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYP27C1 Gene

Membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CYP27C1 Gene COMPARTMENTS Subcellular localization image for CYP27C1 gene
Compartment Confidence
mitochondrion 3
cytosol 1
extracellular 1
nucleus 1

No data available for Gene Ontology (GO) - Cellular Components for CYP27C1 Gene

Pathways & Interactions for CYP27C1 Gene

genes like me logo Genes that share pathways with CYP27C1: view

Pathways by source for CYP27C1 Gene

2 BioSystems pathways for CYP27C1 Gene

Interacting Proteins for CYP27C1 Gene

Gene Ontology (GO) - Biological Process for CYP27C1 Gene

None

No data available for SIGNOR curated interactions for CYP27C1 Gene

Drugs & Compounds for CYP27C1 Gene

(1) Drugs for CYP27C1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
heme Pharma Agonist 0
genes like me logo Genes that share compounds with CYP27C1: view

Transcripts for CYP27C1 Gene

mRNA/cDNA for CYP27C1 Gene

(2) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CYP27C1 Gene

Cytochrome P450, family 27, subfamily C, polypeptide 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CYP27C1 Gene

No ASD Table

Relevant External Links for CYP27C1 Gene

GeneLoc Exon Structure for
CYP27C1
ECgene alternative splicing isoforms for
CYP27C1

Expression for CYP27C1 Gene

mRNA expression in normal human tissues for CYP27C1 Gene

mRNA differential expression in normal tissues according to GTEx for CYP27C1 Gene

This gene is overexpressed in Cervix - Ectocervix (x5.8), Skin - Not Sun Exposed (Suprapubic) (x5.4), and Skin - Sun Exposed (Lower leg) (x5.3).

SOURCE GeneReport for Unigene cluster for CYP27C1 Gene Hs.407639

genes like me logo Genes that share expression patterns with CYP27C1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for CYP27C1 Gene

Orthologs for CYP27C1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CYP27C1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CYP27C1 35
  • 87.54 (n)
  • 87.9 (a)
CYP27C1 36
  • 68 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CYP27C1 35
  • 87.28 (n)
  • 89.78 (a)
CYP27C1 36
  • 70 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LOC470525 35
  • 99.46 (n)
  • 99.73 (a)
CYP27C1 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CYP27C1 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CYP27C1 36
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves CYP27C1 35
  • 75.72 (n)
  • 80.91 (a)
CYP27C1 36
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CYP27C1 36
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC496805 35
  • 71.42 (n)
  • 73.66 (a)
Str.7060 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.5450 35
zebrafish
(Danio rerio)
Actinopterygii cyp27c1 35
  • 65.5 (n)
  • 69.27 (a)
Dr.11380 35
cyp27c1 36
  • 47 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta sad 36
  • 16 (a)
OneToMany
Species with no ortholog for CYP27C1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CYP27C1 Gene

ENSEMBL:
Gene Tree for CYP27C1 (if available)
TreeFam:
Gene Tree for CYP27C1 (if available)

Paralogs for CYP27C1 Gene

Paralogs for CYP27C1 Gene

(6) SIMAP similar genes for CYP27C1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CYP27C1: view

Variants for CYP27C1 Gene

Sequence variations from dbSNP and Humsavar for CYP27C1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs35075135 - 127,187,314(+) CTGGC(A/G)TCAGG reference, missense
rs1566821 -- 127,188,855(-) GCAAG(A/C/T)CTTGA intron-variant
rs885275 -- 127,193,519(+) GAGAC(C/T)CCCAG intron-variant
rs885276 -- 127,193,328(+) AGGGA(A/T)AAGGG intron-variant
rs2896888 -- 127,208,235(+) GAGAG(A/C)AGGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CYP27C1 Gene

Variant ID Type Subtype PubMed ID
dgv1245e1 CNV Complex 17122850

Variation tolerance for CYP27C1 Gene

Residual Variation Intolerance Score: 11% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.07; 37.94% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CYP27C1 Gene

Disorders for CYP27C1 Gene

Relevant External Links for CYP27C1

Genetic Association Database (GAD)
CYP27C1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CYP27C1

No disorders were found for CYP27C1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CYP27C1 Gene

Publications for CYP27C1 Gene

  1. Genetic markers associated with plasma protein C level in African Americans: the atherosclerosis risk in communities (ARIC) study. (PMID: 25376901) Munir M.S. … Folsom A.R. (Genet. Epidemiol. 2014) 3 67
  2. A genome-wide association study of self-rated health. (PMID: 20707712) Mosing M.A. … Martin N.G. (Twin Res Hum Genet 2010) 3
  3. Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants. (PMID: 15128046) Nelson D.R. … Nebert D.W. (Pharmacogenetics 2004) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for CYP27C1 Gene

Sources for CYP27C1 Gene

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