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Aliases for CYP27C1 Gene

Aliases for CYP27C1 Gene

  • Cytochrome P450, Family 27, Subfamily C, Polypeptide 1 2 3
  • EC 1.14.-.- 4

External Ids for CYP27C1 Gene

Previous GeneCards Identifiers for CYP27C1 Gene

  • GC02M127658
  • GC02M127941
  • GC02M120248

Summaries for CYP27C1 Gene

Entrez Gene Summary for CYP27C1 Gene

  • This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. [provided by RefSeq, Jul 2008]

GeneCards Summary for CYP27C1 Gene

CYP27C1 (Cytochrome P450, Family 27, Subfamily C, Polypeptide 1) is a Protein Coding gene. Among its related pathways are Biological oxidations and Cytochrome P450 - arranged by substrate type. GO annotations related to this gene include electron carrier activity and heme binding. An important paralog of this gene is CYP11A1.

Gene Wiki entry for CYP27C1 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYP27C1 Gene

Genomics for CYP27C1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CYP27C1 Gene

Start:
127,183,836 bp from pter
End:
127,220,078 bp from pter
Size:
36,243 bases
Orientation:
Minus strand

Genomic View for CYP27C1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CYP27C1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYP27C1 Gene

No data available for Regulatory Elements for CYP27C1 Gene

Proteins for CYP27C1 Gene

  • Protein details for CYP27C1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q4G0S4-C27C1_HUMAN
    Recommended name:
    Cytochrome P450 27C1
    Protein Accession:
    Q4G0S4
    Secondary Accessions:
    • Q6ZNI7

    Protein attributes for CYP27C1 Gene

    Size:
    372 amino acids
    Molecular mass:
    42632 Da
    Cofactor:
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Quaternary structure:
    No Data Available

neXtProt entry for CYP27C1 Gene

Proteomics data for CYP27C1 Gene at MOPED

Post-translational modifications for CYP27C1 Gene

  • Ubiquitination at Lys128
  • Modification sites at PhosphoSitePlus

Other Protein References for CYP27C1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CYP27C1 Gene

Domains for CYP27C1 Gene

Gene Families for CYP27C1 Gene

HGNC:
  • CYP :Cytochrome P450s
IUPHAR :

Protein Domains for CYP27C1 Gene

Suggested Antigen Peptide Sequences for CYP27C1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q4G0S4

UniProtKB/Swiss-Prot:

C27C1_HUMAN :
  • Q4G0S4
Family:
  • Belongs to the cytochrome P450 family.
genes like me logo Genes that share domains with CYP27C1: view

Function for CYP27C1 Gene

Enzyme Numbers (IUBMB) for CYP27C1 Gene

Gene Ontology (GO) - Molecular Function for CYP27C1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004497 monooxygenase activity IEA --
GO:0005506 iron ion binding IEA --
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA --
GO:0020037 heme binding IEA --
genes like me logo Genes that share ontologies with CYP27C1: view

Animal Model Products

CRISPR Products

miRNA for CYP27C1 Gene

miRTarBase miRNAs that target CYP27C1

No data available for Molecular function , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CYP27C1 Gene

Localization for CYP27C1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYP27C1 Gene

Membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CYP27C1 Gene COMPARTMENTS Subcellular localization image for CYP27C1 gene
Compartment Confidence
mitochondrion 3
cytosol 1
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for CYP27C1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with CYP27C1: view

Pathways for CYP27C1 Gene

genes like me logo Genes that share pathways with CYP27C1: view

Pathways by source for CYP27C1 Gene

2 BioSystems pathways for CYP27C1 Gene

Interacting Proteins for CYP27C1 Gene

Gene Ontology (GO) - Biological Process for CYP27C1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with CYP27C1: view

Compounds for CYP27C1 Gene

(1) HMDB Compounds for CYP27C1 Gene

Compound Synonyms Cas Number PubMed IDs
Heme
  • (protoporphyrinato)iron
14875-96-8
genes like me logo Genes that share compounds with CYP27C1: view

Transcripts for CYP27C1 Gene

mRNA/cDNA for CYP27C1 Gene

(2) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(2) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CYP27C1 Gene

Cytochrome P450, family 27, subfamily C, polypeptide 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CYP27C1

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CYP27C1 Gene

No ASD Table

Relevant External Links for CYP27C1 Gene

GeneLoc Exon Structure for
CYP27C1
ECgene alternative splicing isoforms for
CYP27C1

Expression for CYP27C1 Gene

mRNA expression in normal human tissues for CYP27C1 Gene

mRNA differential expression in normal tissues according to GTEx for CYP27C1 Gene

This gene is overexpressed in Cervix - Ectocervix (5.8), Skin - Not Sun Exposed (Suprapubic) (5.4), and Skin - Sun Exposed (Lower leg) (5.3).

SOURCE GeneReport for Unigene cluster for CYP27C1 Gene Hs.407639

genes like me logo Genes that share expressions with CYP27C1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein expression and mRNA Expression by UniProt/SwissProt for CYP27C1 Gene

Orthologs for CYP27C1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CYP27C1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CYP27C1 36
  • 100 (a)
OneToOne
LOC470525 35
  • 99.46 (n)
  • 99.73 (a)
cow
(Bos Taurus)
Mammalia CYP27C1 35
  • 87.54 (n)
  • 87.9 (a)
CYP27C1 36
  • 68 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CYP27C1 35
  • 87.28 (n)
  • 89.78 (a)
CYP27C1 36
  • 70 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CYP27C1 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CYP27C1 36
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves CYP27C1 35
  • 75.72 (n)
  • 80.91 (a)
CYP27C1 36
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CYP27C1 36
  • 49 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.5450 35
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC496805 35
  • 71.42 (n)
  • 73.66 (a)
Str.7060 35
zebrafish
(Danio rerio)
Actinopterygii cyp27c1 35
  • 65.5 (n)
  • 69.27 (a)
cyp27c1 36
  • 47 (a)
OneToOne
Dr.11380 35
fruit fly
(Drosophila melanogaster)
Insecta sad 36
  • 16 (a)
OneToMany
Species with no ortholog for CYP27C1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CYP27C1 Gene

ENSEMBL:
Gene Tree for CYP27C1 (if available)
TreeFam:
Gene Tree for CYP27C1 (if available)

Paralogs for CYP27C1 Gene

Paralogs for CYP27C1 Gene

Selected SIMAP similar genes for CYP27C1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CYP27C1: view

Variants for CYP27C1 Gene

Sequence variations from dbSNP and Humsavar for CYP27C1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs885275 -- 127,193,519(+) GAGAC(C/T)CCCAG intron-variant
rs885276 -- 127,193,328(+) AGGGA(A/T)AAGGG intron-variant
rs1021866 -- 127,188,943(-) CAGCA(A/C)ATGAT intron-variant
rs1566821 -- 127,188,855(-) GCAAG(A/C)CTTGA intron-variant
rs2089109 -- 127,193,882(+) AGCCA(A/G)CGGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CYP27C1 Gene

Variant ID Type Subtype PubMed ID
dgv1245e1 CNV Complex 17122850

Relevant External Links for CYP27C1 Gene

HapMap Linkage Disequilibrium report
CYP27C1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CYP27C1 Gene

Disorders for CYP27C1 Gene

(1) University of Copenhagen DISEASES for CYP27C1 Gene

Relevant External Links for CYP27C1

Genetic Association Database (GAD)
CYP27C1
genes like me logo Genes that share disorders with CYP27C1: view

No data available for UniProtKB/Swiss-Prot for CYP27C1 Gene

Publications for CYP27C1 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  2. Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants. (PMID: 15128046) Nelson D.R. … Nebert D.W. (Pharmacogenetics 2004) 3
  3. A genome-wide association study of self-rated health. (PMID: 20707712) Mosing M.A. … Martin N.G. (Twin Res Hum Genet 2010) 3
  4. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PMID: 21890473) Wagner S.A. … Choudhary C. (Mol. Cell Proteomics 2011) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4

Products for CYP27C1 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate CYP27C1
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat
  • Predesigned siRNA for gene silencing in human,mouse,rat for CYP27C1
  • Block miRNA regulation of CYP27C1 using miScript Target Protectors
  • antibodies-online proteins for CYP27C1
  • antibodies-online antibodies for CYP27C1
  • antibodies-online kits for CYP27C1

Sources for CYP27C1 Gene

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