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Aliases for CYP26C1 Gene

Aliases for CYP26C1 Gene

  • Cytochrome P450, Family 26, Subfamily C, Polypeptide 1 2 3
  • FFDD4 3 6
  • Cytochrome P450 26C1 3
  • EC 1.14.-.- 4

External Ids for CYP26C1 Gene

Summaries for CYP26C1 Gene

Entrez Gene Summary for CYP26C1 Gene

  • This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme is involved in the catabolism of all-trans- and 9-cis-retinoic acid, and thus contributes to the regulation of retinoic acid levels in cells and tissues. This gene is adjacent to a related gene on chromosome 10q23.33. [provided by RefSeq, Jul 2008]

GeneCards Summary for CYP26C1 Gene

CYP26C1 (Cytochrome P450, Family 26, Subfamily C, Polypeptide 1) is a Protein Coding gene. Diseases associated with CYP26C1 include focal facial dermal dysplasia 4 and focal facial dermal dysplasia. Among its related pathways are Metabolism and Biological oxidations. GO annotations related to this gene include electron carrier activity and heme binding. An important paralog of this gene is CYP26B1.

UniProtKB/Swiss-Prot for CYP26C1 Gene

  • Plays a role in retinoic acid metabolism. Acts on retinoids, including all-trans-retinoic acid (RA) and its stereoisomer 9-cis-RA (preferred substrate)

Tocris Summary for CYP26C1 Gene

  • Cytochrome P450 (CYP450) enzymes are a diverse group of catalysts that contains 57 members in humans. CYPs are usually membrane-bound and are localized to the inner mitochondrial or endoplasmic reticular membrane. CYPs have oxygenase activity and commonly catalyze redox reactions, involving the oxidation of the substrate and reduction of water. This group of enzymes contain a heme ion within the active site, which is essential for catalytic activity. CYPs have been found in all organisms tested and are ubiquitously expressed. They are found at high levels in the liver, where they have an important role in metabolism of drugs and endogenous toxic compounds (for example bilirubin). Most CYPs can metabolize numerous substrates and this accounts for their major role in drug interactions. CYPs also have functions in steroid hormone synthesis, cholesterol synthesis and vitamin D metabolism.

Gene Wiki entry for CYP26C1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYP26C1 Gene

Genomics for CYP26C1 Gene

Genomic Location for CYP26C1 Gene

93,060,808 bp from pter
93,069,547 bp from pter
8,740 bases
Plus strand

Genomic View for CYP26C1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CYP26C1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYP26C1 Gene

Regulatory Elements for CYP26C1 Gene

Proteins for CYP26C1 Gene

  • Protein details for CYP26C1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cytochrome P450 26C1
    Protein Accession:
    Secondary Accessions:
    • Q5VXH6

    Protein attributes for CYP26C1 Gene

    522 amino acids
    Molecular mass:
    57111 Da
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Quaternary structure:
    No Data Available

neXtProt entry for CYP26C1 Gene

Proteomics data for CYP26C1 Gene at MOPED

Post-translational modifications for CYP26C1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CYP26C1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for CYP26C1 Gene

Domains for CYP26C1 Gene

Gene Families for CYP26C1 Gene

  • CYP :Cytochrome P450s

Protein Domains for CYP26C1 Gene

Suggested Antigen Peptide Sequences for CYP26C1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the cytochrome P450 family.:
    • Q6V0L0
genes like me logo Genes that share domains with CYP26C1: view

Function for CYP26C1 Gene

Molecular function for CYP26C1 Gene

UniProtKB/Swiss-Prot Function: Plays a role in retinoic acid metabolism. Acts on retinoids, including all-trans-retinoic acid (RA) and its stereoisomer 9-cis-RA (preferred substrate)
UniProtKB/Swiss-Prot Induction: By retinoic acid.

Enzyme Numbers (IUBMB) for CYP26C1 Gene

Gene Ontology (GO) - Molecular Function for CYP26C1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001972 retinoic acid binding IDA 14532297
GO:0005506 iron ion binding IEA --
GO:0008401 retinoic acid 4-hydroxylase activity IDA 14532297
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen --
GO:0020037 heme binding IEA --
genes like me logo Genes that share ontologies with CYP26C1: view
genes like me logo Genes that share phenotypes with CYP26C1: view

Animal Models for CYP26C1 Gene

MGI Knock Outs for CYP26C1:

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for CYP26C1 Gene

Localization for CYP26C1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYP26C1 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Jensen Localization Image for CYP26C1 Gene COMPARTMENTS Subcellular localization image for CYP26C1 gene
Compartment Confidence
endoplasmic reticulum 4
extracellular 2
plasma membrane 2
cytosol 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CYP26C1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CYP26C1: view

Pathways for CYP26C1 Gene

genes like me logo Genes that share pathways with CYP26C1: view

Pathways by source for CYP26C1 Gene

Interacting Proteins for CYP26C1 Gene

Gene Ontology (GO) - Biological Process for CYP26C1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006766 vitamin metabolic process TAS --
GO:0006805 xenobiotic metabolic process TAS --
GO:0007417 central nervous system development ISS --
GO:0009952 anterior/posterior pattern specification ISS --
GO:0014032 neural crest cell development ISS --
genes like me logo Genes that share ontologies with CYP26C1: view

Compounds for CYP26C1 Gene

(5) Tocris Compounds for CYP26C1 Gene

Compound Action Cas Number
Exemestane Steroidal aromatase (CYP19) inhibitor [107868-30-4]
Letrozole Potent, reversible non-steroidal aromatase inhibitor [112809-51-5]
Methoxyresorufin Fluorometric CYP450 substrate [5725-89-3]
Pentoxyresorufin Fluorometric cytochrome P450 substrate [87687-03-4]
PF 4981517 Selective CYP3A4 inhibitor [1390637-82-7]

(1) HMDB Compounds for CYP26C1 Gene

Compound Synonyms Cas Number PubMed IDs
  • (protoporphyrinato)iron
genes like me logo Genes that share compounds with CYP26C1: view

Transcripts for CYP26C1 Gene

mRNA/cDNA for CYP26C1 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CYP26C1 Gene

Cytochrome P450, family 26, subfamily C, polypeptide 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CYP26C1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c
SP1: -
SP2: - -
SP3: - -

Relevant External Links for CYP26C1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CYP26C1 Gene

mRNA expression in normal human tissues for CYP26C1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CYP26C1 Gene

This gene is overexpressed in Testis (8.4) and Spleen (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CYP26C1 Gene

SOURCE GeneReport for Unigene cluster for CYP26C1 Gene Hs.369993

mRNA Expression by UniProt/SwissProt for CYP26C1 Gene

Tissue specificity: Detected in most tissues at very low level.
genes like me logo Genes that share expressions with CYP26C1: view

Orthologs for CYP26C1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CYP26C1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CYP26C1 36
  • 100 (a)
LOC100610581 35
  • 99.68 (n)
  • 99.81 (a)
(Bos Taurus)
Mammalia CYP26C1 35
  • 88.44 (n)
  • 89.21 (a)
CYP26C1 36
  • 89 (a)
(Mus musculus)
Mammalia Cyp26c1 35
  • 84.56 (n)
  • 87.98 (a)
Cyp26c1 16
Cyp26c1 36
  • 88 (a)
(Ornithorhynchus anatinus)
Mammalia CYP26C1 36
  • 73 (a)
(Rattus norvegicus)
Mammalia Cyp26c1 35
  • 84.4 (n)
  • 86.8 (a)
(Gallus gallus)
Aves CYP26C1 35
  • 72.57 (n)
  • 72.73 (a)
CYP26C1 36
  • 60 (a)
(Anolis carolinensis)
Reptilia CYP26C1 36
  • 58 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.1946 35
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100489980 35
  • 65.67 (n)
  • 69.23 (a)
(Danio rerio)
Actinopterygii cyp26c1 35
  • 62.12 (n)
  • 60.33 (a)
cyp26c1 36
  • 54 (a)
fruit fly
(Drosophila melanogaster)
Insecta Cyp313a1 36
  • 18 (a)
Cyp313a2 36
  • 20 (a)
Cyp313a3 36
  • 20 (a)
Cyp313a4 36
  • 18 (a)
Cyp313a5 36
  • 20 (a)
Cyp313b1 36
  • 18 (a)
Cyp318a1 36
  • 17 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ERG11 36
  • 18 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons CYP718 35
  • 40.93 (n)
  • 32.61 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 29 (a)
CSA.5303 36
  • 36 (a)
Species with no ortholog for CYP26C1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CYP26C1 Gene

Gene Tree for CYP26C1 (if available)
Gene Tree for CYP26C1 (if available)

Paralogs for CYP26C1 Gene

Paralogs for CYP26C1 Gene

Selected SIMAP similar genes for CYP26C1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CYP26C1: view

Variants for CYP26C1 Gene

Sequence variations from dbSNP and Humsavar for CYP26C1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs1538648 -- 93,061,103(-) TGTTC(C/T)AAAAA upstream-variant-2KB, nc-transcript-variant
rs2297918 -- 93,060,445(-) CCGCT(A/G)GCTCC upstream-variant-2KB
rs2422138 -- 93,061,617(+) CCTTT(A/G)CCTAG intron-variant
rs3831311 -- 93,060,063(-) GTTTG(-/CCCGACGACTCTTG)TCAAT upstream-variant-2KB
rs4244352 -- 93,069,709(+) ACCCC(A/G)GAAGC downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for CYP26C1 Gene

Variant ID Type Subtype PubMed ID
nsv895899 CNV Loss 21882294

Relevant External Links for CYP26C1 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CYP26C1 Gene

Disorders for CYP26C1 Gene

(1) OMIM Diseases for CYP26C1 Gene (608428)


  • Focal facial dermal dysplasia 4 (FFDD4) [MIM:614974]: A form of focal facial dermal dysplasia, a group of developmental defects characterized by bitemporal or preauricular skin lesions resembling aplasia cutis congenita. Skin defects occur at the sites of facial fusion during embryogenesis, with temporal lesions situated at the junction between the frontonasal and maxillary facial prominences, and preauricular lesions at the meeting point of the maxillary and mandibular prominences. The ectodermal lesions show consistent histologic abnormalities: atrophy and flattening of the epidermis, replacement of the dermis by loose connective tissue, reduced levels of fragmented elastic tissue and absence of the subcutaneous tissues and adnexal structures. FFDD4 is characterized by isolated, preauricular skin lesions. {ECO:0000269 PubMed:23161670}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for CYP26C1 Gene

Relevant External Links for CYP26C1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with CYP26C1: view

Publications for CYP26C1 Gene

  1. A novel human cytochrome P450, CYP26C1, involved in metabolism of 9- cis and all-trans isomers of retinoic acid. (PMID: 14532297) Taimi M. … Petkovich M. (J. Biol. Chem. 2004) 3 4 23
  2. Focal facial dermal dysplasia, type IV, is caused by mutations in CYP26C1. (PMID: 23161670) Slavotinek A.M. … Desnick R.J. (Hum. Mol. Genet. 2013) 3 4
  3. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4
  4. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 48
  5. Evidence for a functional genetic polymorphism of the human retinoic acid-metabolizing enzyme CYP26A1, an enzyme that may be involved in spina bifida. (PMID: 16933217) Rat E. … Broly F. (Birth Defects Res. Part A Clin. Mol. Teratol. 2006) 3 48

Products for CYP26C1 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • Pathway & Disease-focused RT² Profiler PCR Arrays
  • QIAGEN qRT-PCR Assays for microRNAs that regulate CYP26C1
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for CYP26C1
    • Block miRNA regulation of CYP26C1 using miScript Target Protectors

    Sources for CYP26C1 Gene

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