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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CYP26B1 Gene

protein-coding GIFtS: 59
GCID: GC02M072268

cytochrome P450, family 26, subfamily B, polypeptide 1

Explore 13 diseases affiliated with
CYP26B1 via

MalaCards

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Cytochrome P450, Family 26, Subfamily B, Polypeptide 1¹ ²		P450RAI2² ³
P450RAI-2¹ ²		RHFCA²
Cytochrome P450 26A2² ³		Cytochrome P450 26B1²
Cytochrome P450 Retinoic Acid-Inactivating 2² ³		Cytochrome P450 CYP26B1 Variant 2²
Cytochrome P450RAI-2² ³		Cytochrome P450 Retinoid Metabolizing Protein²
Retinoic Acid-Metabolizing Cytochrome² ³		EC 1.14.-.-³
CYP26A2² ³

External Ids:	HGNC: 20581¹	Entrez Gene: 56603²	Ensembl: ENSG00000003137⁷	OMIM: 605207⁵	UniProtKB: Q9NR63³

Export aliases for CYP26B1 gene to outside databases

Previous GC identifers: GC02M072330 GC02M072209 GC02M072092

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CYP26B1:

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are

monooxygenases that catalyze many reactions involved in drug metabolism and the synthesis of cholesterol, steroids and

other lipids. The enzyme encoded by this gene is involved in the specific inactivation of all-trans-retinoic acid to

hydroxylated forms, such as 4-oxo-, 4-OH-, and 18-OH-all-trans-retinoic acid. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CP26B_HUMAN, Q9NR63

Function: Involved in the metabolism of retinoic acid (RA), rendering this classical morphogen inactive through

oxidation. Involved in the specific inactivation of all-trans-retinoic acid (all-trans-RA), with a preference for the

following substrates: all-trans-RA > 9-cis-RA > 13-cis-RA. Generates several hydroxylated forms of RA, including

4-OH-RA, 4-oxo-RA, and 18-OH-RA. Esential for postnatal survival. Plays a central role in germ cell development: acts

by degrading RA in the developing testis, preventing STRA8 expression, thereby leading to delay of meiosis. Required

for the maintenance of the undifferentiated state of male germ cells during embryonic development in Sertoli cells,

inducing arrest in G0 phase of the cell cycle and preventing meiotic entry. Plays a role in skeletal development, both

at the level of patterning and in the ossification of bone and the establishment of some synovial joints

summary for CYP26B1:

Cytochrome P450 (CYP450) enzymes are a diverse group of catalysts that contains 57 members in humans. CYPs

are usually membrane-bound and are localized to the inner mitochondrial or endoplasmic reticular membrane.

CYPs have oxygenase activity and commonly catalyze redox reactions, involving the oxidation of the substrate

and reduction of water. This group of enzymes contain a heme ion within the active site, which is essential

for catalytic activity. CYPs have been found in all organisms tested and are ubiquitously expressed. They

are found at high levels in the liver, where they have an important role in metabolism of drugs and

endogenous toxic compounds (for example bilirubin). Most CYPs can metabolize numerous substrates and this

accounts for their major role in drug interactions. CYPs also have functions in steroid hormone synthesis,

cholesterol synthesis and vitamin D metabolism.

Gene Wiki entry for CYP26B1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_022184.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CYP26B1 gene promoter:
E2F-4 E2F-3a E2F-5 Pax-5 MEF-2 E2F-2 E2F E2F-1 aMEF-2 ZIC2/Zic2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CYP26B1 promoter sequence

Search SABiosciences Chromatin IP Primers for CYP26B1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CYP26B1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p13.2 Ensembl cytogenetic band: 2p13.2 HGNC cytogenetic band: 2p12

CYP26B1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CYP26B1 gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M072268: view genomic region (about GC identifiers)

Start:	72,356,367 bp from pter	End:	72,375,167 bp from pter
Size:	18,801 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CP26B_HUMAN, Q9NR63 (See protein sequence)

Recommended Name: Cytochrome P450 26B1

Size: 512 amino acids; 57513 Da

Cofactor: Heme group (By similarity)

Subcellular location: Endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). Microsome membrane;

Peripheral membrane protein (By similarity)

Sequence caution: Sequence=BAH12154.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

Secondary accessions: B2R8M7 B7Z2K6 B7Z2P4 B7Z3B8 E4W5W7 Q32MC0 Q53TW1 Q9NP41

Alternative splicing: 3 isoforms: Q9NR63-1 Q9NR63-2 Q9NR63-3 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CYP26B1: NX_Q9NR63

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9NR63

CYP26B1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_063938.1

ENSEMBL proteins:

ENSP00000001146 ENSP00000401465 ENSP00000430888 ENSP00000430871 ENSP00000443304

Reactome Protein details: Q9NR63
Human Recombinant Protein Products:

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	Novus Biologicals CYP26B1 Proteins Novus Biologicals CYP26B1 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for CYP26B1

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005783	endoplasmic reticulum	NAS	--
GO:0005789	endoplasmic reticulum membrane	TAS	--
GO:0005792	microsome	--	--

CYP26B1 for ontologies About GeneDecksing

CYP26B1 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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	GenScript Custom Superior Antibodies Services for CYP26B1
	Novus Biologicals CYP26B1 Antibodies
	Abcam antibodies for CYP26B1
	Uscn Antibodies for CYP26B1
	ThermoFisher Antibodies for CYP26B1

Assay Products for CYP26B1:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for CYP26B1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CYP26B1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CYP26B1 for domains About GeneDecksing

3 InterPro domains/families:

IPR001128 Cyt_P450

IPR017972 Cyt_P450_CS

IPR002403 Cyt_P450_E_grp-IV

Graphical View of Domain Structure for InterPro Entry Q9NR63

ProtoNet protein and cluster: Q9NR63

1 Blocks protein family: IPB002403 E-class P450 group IV signature

UniProtKB/Swiss-Prot: CP26B_HUMAN, Q9NR63

Similarity: Belongs to the cytochrome P450 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary: