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CYP26A1 Gene

protein-coding   GIFtS: 65
GCID: GC10P094823

Cytochrome P450, Family 26, Subfamily A, Polypeptide 1

(Previous names: cytochrome P450, subfamily XXVIA, polypeptide 1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cytochrome P450, Family 26, Subfamily A, Polypeptide 11 2     P450RAI12 3
Cytochrome P450, Subfamily XXVIA, Polypeptide 11 2     hP450RAI2 3
Cytochrome P450 Retinoic Acid-Inactivating 12 3     CP262
Cytochrome P450RAI2 3     P450RAI2
Retinoic Acid 4-Hydroxylase2 3     Cytochrome P450 26A12
Retinoic Acid-Metabolizing Cytochrome2 3     P450, Retinoic Acid-Inactivating, 12
CYP262 3     EC 1.14.-.-3

External Ids:    HGNC: 26031   Entrez Gene: 15922   Ensembl: ENSG000000955967   OMIM: 6022395   UniProtKB: O431743   

Export aliases for CYP26A1 gene to outside databases

Previous GC identifers: GC10P093726 GC10P094066 GC10P094953 GC10P094486 GC10P094497 GC10P088460


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CYP26A1 Gene:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are
monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids
and other lipids. This endoplasmic reticulum protein acts on retinoids, including all-trans-retinoic acid (RA),
with both 4-hydroxylation and 18-hydroxylation activities. This enzyme regulates the cellular level of retinoic
acid which is involved in regulation of gene expression in both embryonic and adult tissues. Two alternatively
spliced transcript variants of this gene, which encode the distinct isoforms, have been reported. (provided by
RefSeq, Jul 2008)

GeneCards Summary for CYP26A1 Gene:
CYP26A1 (cytochrome P450, family 26, subfamily A, polypeptide 1) is a protein-coding gene. Diseases associated with CYP26A1 include caudal regression syndrome, and imperforate anus. GO annotations related to this gene include electron carrier activity and heme binding. An important paralog of this gene is CYP51A1.

UniProtKB/Swiss-Prot: CP26A_HUMAN, O43174
Function: Plays a key role in retinoic acid metabolism. Acts on retinoids, including all-trans-retinoic acid (RA)
and its stereoisomer 9-cis-RA. Capable of both 4-hydroxylation and 18-hydroxylation. Responsible for generation
of several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA and 18-OH-RA

summary for CYP26A1 Gene:
Cytochrome P450 (CYP450) enzymes are a diverse group of catalysts that contains 57 members in humans. CYPs
are usually membrane-bound and are localized to the inner mitochondrial or endoplasmic reticular membrane.
CYPs have oxygenase activity and commonly catalyze redox reactions, involving the oxidation of the substrate
and reduction of water. This group of enzymes contain a heme ion within the active site, which is essential
for catalytic activity. CYPs have been found in all organisms tested and are ubiquitously expressed. They
are found at high levels in the liver, where they have an important role in metabolism of drugs and
endogenous toxic compounds (for example bilirubin). Most CYPs can metabolize numerous substrates and this
accounts for their major role in drug interactions. CYPs also have functions in steroid hormone synthesis,
cholesterol synthesis and vitamin D metabolism.

Gene Wiki entry for CYP26A1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000010.11  NC_018921.2  NT_030059.14  
Regulatory elements:
   Regulatory transcription factor binding sites in the CYP26A1 gene promoter:
         NRSF form 1   NRSF form 2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CYP26A1 promoter sequence
   Search Chromatin IP Primers for CYP26A1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CYP26A1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q23-q24   Ensembl cytogenetic band:  10q23.33   HGNC cytogenetic band: 10q23-q24

CYP26A1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CYP26A1 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P094823:  view genomic region     (about GC identifiers)

Start:
94,833,232 bp from pter      End:
94,837,647 bp from pter
Size:
4,416 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CP26A_HUMAN, O43174 (See protein sequence)
Recommended Name: Cytochrome P450 26A1  
Size: 497 amino acids; 56199 Da
Cofactor: Heme group (By similarity)
Secondary accessions: B3KNI4 Q5VXH9 Q5VXI0
Alternative splicing: 2 isoforms:  O43174-1   O43174-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CYP26A1: NX_O43174

Explore proteomics data for CYP26A1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CYP26A1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_000774.2  NP_476498.1  

    ENSEMBL proteins: 
     ENSP00000360586   ENSP00000224356   ENSP00000377695  
    Reactome Protein details: O43174

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CYP: Cytochrome P450s

    IUPHAR Guide to PHARMACOLOGY protein family classification: CYP26A1
    CYP24, CYP26 and CYP27 families

    3 InterPro protein domains:
     IPR001128 Cyt_P450
     IPR017972 Cyt_P450_CS
     IPR002403 Cyt_P450_E_grp-IV

    Graphical View of Domain Structure for InterPro Entry O43174

    ProtoNet protein and cluster: O43174

    1 Blocks protein domain: IPB002403 E-class P450 group IV signature

    UniProtKB/Swiss-Prot: CP26A_HUMAN, O43174
    Similarity: Belongs to the cytochrome P450 family


    CYP26A1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CP26A_HUMAN, O43174
    Function: Plays a key role in retinoic acid metabolism. Acts on retinoids, including all-trans-retinoic acid (RA)
    and its stereoisomer 9-cis-RA. Capable of both 4-hydroxylation and 18-hydroxylation. Responsible for generation
    of several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA and 18-OH-RA
    Induction: By retinoic acid

         Genatlas biochemistry entry for CYP26A1:
    cytochrome p450,family XXVI,involved in extrahepatic metabolism of retinoic acid

         Enzyme Number (IUBMB): EC 1.14.-.-1

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001972retinoic acid binding IDA10823918
    GO:0005506iron ion binding IEA--
    GO:0008401retinoic acid 4-hydroxylase activity IDA10823918
    GO:0016705oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen ----
    GO:0019825oxygen binding TAS9228017
         
    CYP26A1 for ontologies           About GeneDecksing


    Phenotypes:
         14 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Cyp26a1):
     cardiovascular system  cellular  craniofacial  digestive/alimentary  embryogenesis 
     growth/size/body  limbs/digits/tail  mortality/aging  nervous system  no phenotypic analysis 
     normal  renal/urinary system  reproductive system  skeleton 

    CYP26A1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for CYP26A1: Cyp26a1tm1.1Ptk Cyp26a1tm1.1Hmd

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CYP26A1
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    miRNA
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    8 qRT-PCR Assays for microRNAs that regulate CYP26A1:
    hsa-miR-656 hsa-miR-548am hsa-miR-369-3p hsa-miR-889 hsa-miR-374b hsa-miR-548x hsa-miR-374a hsa-miR-664
    SwitchGear 3'UTR luciferase reporter plasmidCYP26A1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CYP26A1

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 2): CYP26A1 (NM_057157)
    Browse Sino Biological Human cDNA Clones
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYP26A1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CP26A_HUMAN, O43174: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral
    membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    chloroplast3
    extracellular2
    nucleus2
    golgi apparatus1
    lysosome1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane TAS--

    CYP26A1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CYP26A1 About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1Cytochrome P450 - arranged by substrate type
    Cytochrome P450 - arranged by substrate type0.75
    cytochrome P4500.74
    Phase 1 - Functionalization of compounds0.75
    Vitamins0.00
    2Biological oxidations
    Biological oxidations0.56
    metapathway biotransformation0.42
    3Metabolism
    Metabolism0.38
    4Chemical carcinogenesis
    Retinol metabolism0.35
    5Vitamin A and carotenoid metabolism
    Vitamin A and carotenoid metabolism

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5 BioSystems Pathways for CYP26A1
        cytochrome P450
    Adipogenesis
    Vitamin A and carotenoid metabolism
    Nuclear receptors in lipid metabolism and toxicity
    metapathway biotransformation

    1 Reactome Pathway for CYP26A1
        Vitamins


    1 Kegg Pathway  (Kegg details for CYP26A1):
        Retinol metabolism


    CYP26A1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CYP26A1: 
              Notch Signaling Targets in human mouse rat
              Drug Metabolism: Phase I Enzymes in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for CYP26A1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CYP26A1 (ENSP000002243564) via UniProtKB, MINT, STRING, and/or I2D (see all 74)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ADH1AENSP000002096684STRING: ENSP00000209668
    ADH4ENSP000002655124STRING: ENSP00000265512
    ADH5ENSP000002964124STRING: ENSP00000296412
    ADH6ENSP000003783594STRING: ENSP00000378359
    ADH7ENSP000002096654STRING: ENSP00000209665
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006766vitamin metabolic process TAS--
    GO:0006805xenobiotic metabolic process TAS--
    GO:0007417central nervous system development IEA--
    GO:0008152metabolic process TAS9228017
    GO:0009952anterior/posterior pattern specification IEA--

    CYP26A1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for CYP26A1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    PF 4981517Selective CYP3A4 inhibitor[1390637-82-7]
    MethoxyresorufinFluorometric CYP450 substrate[5725-89-3]
    Letrozole Potent, reversible non-steroidal aromatase inhibitor [112809-51-5]
    ExemestaneSteroidal aromatase (CYP19) inhibitor[107868-30-4]
    PentoxyresorufinFluorometric cytochrome P450 substrate[87687-03-4]

    1 HMDB Compound for CYP26A1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Heme(protoporphyrinato)iron (see all 19)14875-96-8--

    4 DrugBank Compounds for CYP26A1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Acitretin-- 55079-83-9enzymesubstrate19934256
    Etretinate-- 54350-48-0enzymesubstrate19934256
    Ketoconazole2% (see all 6)65277-42-1enzymeinhibitor19934256
    Vitamin A[11,12-3H]-Retinol (see all 18)68-26-8enzymeinducer19934256

    10 Novoseek inferred chemical compound relationships for CYP26A1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    liarozole 89.5 10 8757760 (4), 9716180 (1), 15597402 (1), 19294396 (1) (see all 5)
    retinoic acid 86.8 272 16194896 (11), 11994980 (8), 11302942 (7), 9716180 (5) (see all 61)
    retinoid 84.6 19 19294396 (3), 9564181 (1), 11302942 (1), 9740237 (1) (see all 12)
    am 580 83.4 7 11302942 (2), 11690641 (2)
    retinaldehyde 77.8 1 20063272 (1)
    ttab 71.2 2 10953040 (2)
    vitamin a 71 17 14704332 (3), 8757760 (2), 19016711 (1), 16194896 (1) (see all 7)
    n-(4-hydroxyphenyl)retinamide 52.2 1 15448016 (1)
    isotretinoin 46.8 4 19525031 (2), 10545224 (1)
    ketoconazole 45.6 2 10874126 (1), 14532297 (1)



    CYP26A1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CYP26A1 gene (2 alternative transcripts): 
    NM_000783.3  NM_057157.2  

    Unigene Cluster for CYP26A1:

    Cytochrome P450, family 26, subfamily A, polypeptide 1
    Hs.150595  [show with all ESTs]
    Unigene Representative Sequence: AK027560
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000371531(uc001kik.1) ENST00000224356 ENST00000394139(uc001kil.2)

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      QuantiFast Probe-based Assays in human, mouse, rat CYP26A1

    Additional mRNA sequence: 

    AF005418.1 AK027560.1 AK075374.1 

    3 DOTS entries:

    DT.310567  DT.91756297  DT.100680587 

    Selected AceView cDNA sequences (see all 31):

    NM_000783 BM706435 BM684420 CR598753 NM_057157 CR604765 AK075374 BM930903 
    BX281858 BQ011865 AL532445 AW513600 AI863962 BX955261 BQ010588 AF005418 
    BQ011150 BM797145 R45372 AL539668 AK027560 AL532444 BF055367 AI082714 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CYP26A1 (see all 6)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c
    SP1:        -     -                                         -           -                                 
    SP2:                                                        -           -                                 
    SP3:                                -                       -           -                                 
    SP4:                                                                                                      
    SP5:                                                                    -                                 


    ECgene alternative splicing isoforms for CYP26A1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CYP26A1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGAAATCTG
    CYP26A1 Expression
    About this image


    CYP26A1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 13) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 7 entries
             hIPS1
     
     Epiblast (Early Embryonic Tissues)    fully expand to see all 3 entries
             Epiblast Cells Epiblast
             Epiblast Stem Cell line 5
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Paraxial Mesoderm Cells Branchial Arch 1
             HyStem+BMP4-induced MEL2 cells
     
     Liver (Hepatobiliary System)
             Perivenous Hepatocytes Liver Lobule
     
     Primitive Streak (Early Embryonic Tissues)
             Primitive streak-like cells
    CYP26A1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CYP26A1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.150595

    UniProtKB/Swiss-Prot: CP26A_HUMAN, O43174
    Tissue specificity: Highest levels in adult liver, heart, pituitary gland, adrenal gland, placenta and regions of
    the brain

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CYP26A1 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cyp26a11 , 5 cytochrome P450, family 26, subfamily a, polypeptide more1, 5 89.81(n)1
    93.96(a)1
      19 (32.36 cM)5
    130821  NM_007811.21  NP_031837.21 
     376978085 
    chicken
    (Gallus gallus)
    Aves CYP26A11 cytochrome P450, family 26, subfamily A, polypeptide more 77.85(n)
    80.28(a)
      408183  NM_001001129.1  NP_001001129.1 
    lizard
    (Anolis carolinensis)
    Reptilia CYP26A16
    cytochrome P450, family 26, subfamily A, polypepti...
    76(a)
    1 ↔ 1
    GL343219.1(2208160-2227392)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3980942 retinoic acid converting enzyme 73.32(n)    AF057566.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cyp26a12 cytochrome P450, subfamily XXVIA, polypeptide 1 73.14(n)   30381  U68234.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Cyp313a36
    Cyp313a16
    (see all 7)
    Cyp313a1
    (see all 7)
    20(a)
    20(a)
    (see all 7)
    many ↔ many
    many ↔ many
    (see all 7)
    3R(8063001-8064831)
    3R(10346771-10348786)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ERG116
    Lanosterol 14-alpha-demethylase; catalyzes the C-1...
    20(a)
    1 → many
    VIII(120091-121683) YHR007C
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons CYP716A21 CYP716A2 44.56(n)
    33.67(a)
      833611  NM_123005.1  NP_198463.1 
    rice
    (Oryza sativa)
    Liliopsida Os07g05203001 Os07g0520300 45.49(n)
    31.56(a)
      4343399  NM_001066336.1  NP_001059801.1 


    ENSEMBL Gene Tree for CYP26A1 (if available)
    TreeFam Gene Tree for CYP26A1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CYP26A1 gene
    CYP51A12  CYP26B12  CYP26C12  
    3 SIMAP similar genes for CYP26A1 using alignment to 1 protein entry:     CP26A_HUMAN:
    DKFZp686G0638    CYP26B1    CYP26C1

    CYP26A1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CYP26A1 (see all 163)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs591310041,2
    C--88459805(+) AGCAGAGAGA   
      GCAG
    /-
    GTGCG
    2 -- cds11Minor allele frequency- -:0.00NA 2
    rs2018566541,2
    C--95195067(+) AAAAC-/AAAAAA 1 -- us2k10--------
    rs589930901,2
    C--95195252(+) CCCCC-/A/AC  
            
    CCCCC
    1 -- us2k11NA 2
    rs111872681,2
    C,F,H--95195272(+) CCCCTT/ACAAGA 1 -- us2k112Minor allele frequency- A:0.04NS EA NA WA CSA 545
    rs44112271,2
    C,F,H--95195322(+) CCTGCC/GGGACG 1 -- us2k1 tfbs39Minor allele frequency- G:0.38NS EA NA CSA WA 758
    rs680406291,2
    C,F--95195332(+) GCCCCC/GGCCGG 1 -- us2k14Minor allele frequency- G:0.49NA 126
    rs1916488221,2
    --95195439(+) GCGAGA/GTGGCC 1 -- us2k10--------
    rs1841559681,2
    --95195567(+) GGAGGC/TGCTGT 2 -- us2k10--------
    rs1887593381,2
    --95195583(+) AAGGGA/GCGGAC 2 -- us2k10--------
    rs665265271,2
    C--95195590(+) GGACCC/TGGGAT 2 -- us2k14Minor allele frequency- T:0.04WA NA EA 360

    HapMap Linkage Disequilibrium report for CYP26A1 (94833232 - 94837647 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CYP26A1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv895899CNV Loss21882294

    The Human Cytochrome P450 Allele Nomenclature Database: CYP26A1 
    Human Gene Mutation Database (HGMD): CYP26A1
    Locus Specific Mutation Databases (LSDB): CYP26A1

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602239    OMIM disorders: --

    Selected diseases for CYP26A1 (see all 38):    
    About MalaCards
    caudal regression syndrome    imperforate anus    congenital diaphragmatic hernia    acute promyelocytic leukemia
    lyme disease    allergic asthma    open-angle glaucoma    primary open angle glaucoma
    acne    refractive error    spina bifida    urethritis
    neural tube defects    digeorge syndrome    ankylosing spondylitis    spondylitis
    labyrinthitis    glaucoma    teratocarcinoma    leiomyoma

    3 diseases from the University of Copenhagen DISEASES database for CYP26A1:
    Imperforate anus     Lyme disease     Spina bifida

    CYP26A1 for disorders           About GeneDecksing

    9 Novoseek inferred disease relationships for CYP26A1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemia promyelocytic acute 61.5 2 16194896 (2)
    carcinoma embryonal 45.3 2 18502188 (1), 10479456 (1)
    vitamin a deficiency 39.1 2 14704332 (1)
    promyelocytic leukemia 34.8 6 11994980 (3), 15896339 (2)
    hnscc 34.7 2 11309353 (2)
    leukemia 0 4 15896339 (3)
    breast cancer 0 2 9716180 (1), 11025452 (1)
    tumors 0 7 15448016 (2), 9228017 (1), 15597402 (1)
    cancer 0 1 9857269 (1)

    Genetic Association Database (GAD): CYP26A1
    Human Genome Epidemiology (HuGE) Navigator: CYP26A1 (9 documents)

    Export disorders for CYP26A1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CYP26A1 gene, integrated from 10 sources (see all 106):
    (articles sorted by number of sources associating them with CYP26A1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA cloning of human retinoic acid-metabolizing enzyme (hP450RAI) identifies a novel family of cytochromes P450. (PubMed id 9228017)1, 2, 3, 9 White J.A.... Petkovich M. (J. Biol. Chem. 1997)
    2. Expression of cytochrome P450RAI (CYP26) in human fetal hepatic and cephalic tissues. (PubMed id 9826557)1, 2, 9 Trofimova-Griffin M.E. and Juchau M.R. (Biochem. Biophys. Res. Commun. 1998)
    3. Human retinoic acid (RA) 4-hydroxylase (CYP26) is highly specific for all-trans-RA and can be induced through RA receptors in human breast and colon carcinoma cells. (PubMed id 9716180)1, 2, 9 Sonneveld E.... van der Saag P.T. (Cell Growth Differ. 1998)
    4. A human ALDH1A2 gene variant is associated with increased newborn kidney size and serum retinoic acid. (PubMed id 20375987)1, 4 El Kares R....Goodyer P. (Kidney Int. 2010)
    5. Analysis of lipid pathway genes indicates association of sequence variation near SREBF1/TOM1L2/ATPAF2 with dementia risk. (PubMed id 20167577)1, 4 Reynolds C.A....Prince J.A. (Hum. Mol. Genet. 2010)
    6. Biological, clinical and population relevance of 95 loci for blood lipids. (PubMed id 20686565)1, 4 Teslovich T.M....Kathiresan S. (Nature 2010)
    7. Primary open-angle glaucoma: association with cholesterol 24S-hydroxylase (CYP46A1) gene polymorphism and plasma 24-hydroxycholesterol levels. (PubMed id 19553612)1, 4 Fourgeux C....Bretillon L. (amp 2009)
    8. Positive association between ALDH1A2 and schizophrenia in the Chinese population. (PubMed id 19703508)1, 4 Wan C....He L. (amp 2009)
    9. Evidence for a functional genetic polymorphism of the human retinoic acid-metabolizing enzyme CYP26A1, an enzyme that may be involved in spina bifida. (PubMed id 16933217)1, 4 Rat E....Broly F. (Birth Defects Res. Part A Clin. Mol. Teratol. 2006)
    10. Mutational screening of the CYP26A1 gene in patients with caudal regression syndrome. (PubMed id 16463413)1, 4 De Marco P....Capra V. (Birth Defects Res. Part A Clin. Mol. Teratol. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1592 HGNC: 2603 AceView: CYP26A1 Ensembl:ENSG00000095596 euGenes: HUgn1592
    ECgene: CYP26A1 Kegg: 1592 H-InvDB: CYP26A1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CYP26A1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CYP26A1 gene:
    Search GeneIP for patents involving CYP26A1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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