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Aliases for CYP26A1 Gene

Aliases for CYP26A1 Gene

  • Cytochrome P450 Family 26 Subfamily A Member 1 2 3 5
  • Cytochrome P450, Family 26, Subfamily A, Polypeptide 1 2 3
  • Cytochrome P450, Subfamily XXVIA, Polypeptide 1 2 3
  • Cytochrome P450 Retinoic Acid-Inactivating 1 3 4
  • Retinoic Acid-Metabolizing Cytochrome 3 4
  • Retinoic Acid 4-Hydroxylase 3 4
  • Cytochrome P450RAI 3 4
  • P450RAI1 3 4
  • HP450RAI 3 4
  • CYP26 3 4
  • P450, Retinoic Acid-Inactivating, 1 3
  • Cytochrome P450 26A1 3
  • EC 1.14.13.- 4
  • P450RAI 3
  • CP26 3

External Ids for CYP26A1 Gene

Previous GeneCards Identifiers for CYP26A1 Gene

  • GC10P093726
  • GC10P094066
  • GC10P094953
  • GC10P094486
  • GC10P094497
  • GC10P094823
  • GC10P088460

Summaries for CYP26A1 Gene

Entrez Gene Summary for CYP26A1 Gene

  • This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein acts on retinoids, including all-trans-retinoic acid (RA), with both 4-hydroxylation and 18-hydroxylation activities. This enzyme regulates the cellular level of retinoic acid which is involved in regulation of gene expression in both embryonic and adult tissues. Two alternatively spliced transcript variants of this gene, which encode the distinct isoforms, have been reported. [provided by RefSeq, Jul 2008]

GeneCards Summary for CYP26A1 Gene

CYP26A1 (Cytochrome P450 Family 26 Subfamily A Member 1) is a Protein Coding gene. Diseases associated with CYP26A1 include Caudal Regression Syndrome and Mixed Germ Cell Cancer. Among its related pathways are Nuclear Receptors in Lipid Metabolism and Toxicity and Metabolism. GO annotations related to this gene include iron ion binding and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen. An important paralog of this gene is CYP26C1.

UniProtKB/Swiss-Prot for CYP26A1 Gene

  • Plays a key role in retinoic acid metabolism. Acts on retinoids, including all-trans-retinoic acid (RA) and its stereoisomer 9-cis-RA. Capable of both 4-hydroxylation and 18-hydroxylation. Responsible for generation of several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA and 18-OH-RA.

  • Has also a significant activity in oxidation of tazarotenic acid and may therefore metabolize that xenobiotic in vivo.

Tocris Summary for CYP26A1 Gene

  • Cytochrome P450 (CYP450) enzymes are a diverse group of catalysts that contains 57 members in humans. CYPs are usually membrane-bound and are localized to the inner mitochondrial or endoplasmic reticular membrane. CYPs have oxygenase activity.

Gene Wiki entry for CYP26A1 Gene

Additional gene information for CYP26A1 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYP26A1 Gene

Genomics for CYP26A1 Gene

Regulatory Elements for CYP26A1 Gene

Enhancers for CYP26A1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10H093375 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10.4 +303.5 303525 2.9 RB1 ARID4B BMI1 ZNF2 ZSCAN9 RAD21 RFX5 TCF12 ZNF143 ZNF391 MYOF CYP26A1 HHEX GC10P093383 RPL17P34
GH10H093071 1.6 FANTOM5 Ensembl ENCODE 7.2 +0.0 41 4 ATF1 FOXA2 MLX ZNF133 ARID4B YY1 GLIS2 CBX5 KLF7 ATF7 PDE6C CYP26A1 EXOC6 NIP7P1 GC10M093106
GH10H093378 1.1 Ensembl ENCODE dbSUPER 10.4 +306.8 306827 2.9 SCRT1 JUN JUNB BATF JUND BCL11A SCRT2 ZNF600 FOS MYOF CYP26A1 GC10P093383 RPL17P34
GH10H093106 0.9 ENCODE 11.8 +33.3 33344 0.2 ELF3 FOXA2 ATF1 MLX ARID4B BATF THRB RAD21 RARA TCF12 CYP26A1 NIP7P1 GC10M093106
GH10H093029 0.9 Ensembl ENCODE 11.4 -42.9 -42852 1.5 JUN CEBPB EP300 ZNF664 JUND POLR2A FOS PRDM1 ENSG00000226425 CYP26C1 CYP26A1 ENSG00000225118
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CYP26A1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for CYP26A1 Gene

Genomic Locations for CYP26A1 Gene
chr10:93,073,475-93,077,890
(GRCh38/hg38)
Size:
4,416 bases
Orientation:
Plus strand
chr10:94,833,232-94,837,647
(GRCh37/hg19)

Genomic View for CYP26A1 Gene

Genes around CYP26A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CYP26A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CYP26A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYP26A1 Gene

Proteins for CYP26A1 Gene

  • Protein details for CYP26A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43174-CP26A_HUMAN
    Recommended name:
    Cytochrome P450 26A1
    Protein Accession:
    O43174
    Secondary Accessions:
    • B3KNI4
    • Q5VXH9
    • Q5VXI0

    Protein attributes for CYP26A1 Gene

    Size:
    497 amino acids
    Molecular mass:
    56199 Da
    Cofactor:
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CYP26A1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CYP26A1 Gene

Post-translational modifications for CYP26A1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CYP26A1 Gene

No data available for DME Specific Peptides for CYP26A1 Gene

Domains & Families for CYP26A1 Gene

Gene Families for CYP26A1 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CYP26A1 Gene

Suggested Antigen Peptide Sequences for CYP26A1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43174

UniProtKB/Swiss-Prot:

CP26A_HUMAN :
  • Belongs to the cytochrome P450 family.
Family:
  • Belongs to the cytochrome P450 family.
genes like me logo Genes that share domains with CYP26A1: view

Function for CYP26A1 Gene

Molecular function for CYP26A1 Gene

GENATLAS Biochemistry:
cytochrome p450,family XXVI,involved in extrahepatic metabolism of retinoic acid
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=0.24 uM for tazarotenic acid (measured in vitro by the production of tazarotenic acid-sulfoxide) {ECO:0000269 PubMed:26937021}; KM=0.39 uM for tazarotenic acid (measured in vitro by the production of hydroxytazarotenic acid) {ECO:0000269 PubMed:26937021};
UniProtKB/Swiss-Prot Function:
Plays a key role in retinoic acid metabolism. Acts on retinoids, including all-trans-retinoic acid (RA) and its stereoisomer 9-cis-RA. Capable of both 4-hydroxylation and 18-hydroxylation. Responsible for generation of several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA and 18-OH-RA.
UniProtKB/Swiss-Prot Function:
Has also a significant activity in oxidation of tazarotenic acid and may therefore metabolize that xenobiotic in vivo.
UniProtKB/Swiss-Prot Induction:
By retinoic acid.

Enzyme Numbers (IUBMB) for CYP26A1 Gene

Phenotypes From GWAS Catalog for CYP26A1 Gene

Gene Ontology (GO) - Molecular Function for CYP26A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001972 retinoic acid binding IDA 10823918
GO:0004497 monooxygenase activity IEA --
GO:0005506 iron ion binding IEA --
GO:0008401 retinoic acid 4-hydroxylase activity TAS --
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with CYP26A1: view
genes like me logo Genes that share phenotypes with CYP26A1: view

Animal Models for CYP26A1 Gene

MGI Knock Outs for CYP26A1:

Animal Model Products

miRNA for CYP26A1 Gene

miRTarBase miRNAs that target CYP26A1

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CYP26A1 Gene

Localization for CYP26A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYP26A1 Gene

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CYP26A1 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 2
nucleus 2
plasma membrane 1
peroxisome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CYP26A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane IEA --
GO:0031090 organelle membrane IEA --
GO:0043231 intracellular membrane-bounded organelle IEA --
genes like me logo Genes that share ontologies with CYP26A1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CYP26A1 Gene

Pathways & Interactions for CYP26A1 Gene

genes like me logo Genes that share pathways with CYP26A1: view

Gene Ontology (GO) - Biological Process for CYP26A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006766 vitamin metabolic process TAS --
GO:0006805 xenobiotic metabolic process IDA 26937021
GO:0016125 sterol metabolic process IBA --
GO:0034653 retinoic acid catabolic process IDA 10823918
GO:0042573 retinoic acid metabolic process IDA 9716180
genes like me logo Genes that share ontologies with CYP26A1: view

No data available for SIGNOR curated interactions for CYP26A1 Gene

Drugs & Compounds for CYP26A1 Gene

(13) Drugs for CYP26A1 Gene - From: DrugBank, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Acitretin Approved Pharma Enzyme, substrate Metabolite of etretinate 30
Ketoconazole Approved, Investigational Pharma Pore Blocker, Enzyme, inhibitor Inhibitor of cyclosporine oxidase and testosterone 6 beta-hydroxylase 178
Vitamin A Approved, Vet_approved Nutra Enzyme, inducer 511
Tretinoin Approved, Investigational Nutra Target 232
Talarozole Investigational Pharma Target Cytochrome P450 inhibitor 0

(6) Additional Compounds for CYP26A1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(5) Tocris Compounds for CYP26A1 Gene

Compound Action Cas Number
Anastrozole Potent aromatase (CYP19) inhibitor 120511-73-1
Exemestane Steroidal aromatase (CYP19) inhibitor 107868-30-4
Ketoconazole Cytochrome P450c17 inhibitor 65277-42-1
TMS Cytochrome P450 1B1 inhibitor 24144-92-1
YM 511 Potent aromatase (CYP19) inhibitor 148869-05-0
genes like me logo Genes that share compounds with CYP26A1: view

Transcripts for CYP26A1 Gene

Unigene Clusters for CYP26A1 Gene

Cytochrome P450, family 26, subfamily A, polypeptide 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CYP26A1 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c
SP1: - - - -
SP2: - -
SP3: - - -
SP4:
SP5: -
SP6:

Relevant External Links for CYP26A1 Gene

GeneLoc Exon Structure for
CYP26A1
ECgene alternative splicing isoforms for
CYP26A1

Expression for CYP26A1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CYP26A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CYP26A1 Gene

This gene is overexpressed in Liver (x34.1).

Protein differential expression in normal tissues from HIPED for CYP26A1 Gene

This gene is overexpressed in Breast (67.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CYP26A1 Gene



Protein tissue co-expression partners for CYP26A1 Gene

NURSA nuclear receptor signaling pathways regulating expression of CYP26A1 Gene:

CYP26A1

SOURCE GeneReport for Unigene cluster for CYP26A1 Gene:

Hs.150595

mRNA Expression by UniProt/SwissProt for CYP26A1 Gene:

O43174-CP26A_HUMAN
Tissue specificity: Highest levels in adult liver, heart, pituitary gland, adrenal gland, placenta and regions of the brain.

Evidence on tissue expression from TISSUES for CYP26A1 Gene

  • Liver(2.5)
genes like me logo Genes that share expression patterns with CYP26A1: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CYP26A1 Gene

Orthologs for CYP26A1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CYP26A1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CYP26A1 34
  • 100 (a)
OneToOne
LOC450614 33
  • 99.8 (n)
dog
(Canis familiaris)
Mammalia CYP26C1 34
  • 95 (a)
OneToOne
CYP26A1 33
  • 92.42 (n)
cow
(Bos Taurus)
Mammalia CYP26A1 33 34
  • 91.95 (n)
mouse
(Mus musculus)
Mammalia Cyp26a1 33 16 34
  • 89.81 (n)
rat
(Rattus norvegicus)
Mammalia Cyp26a1 33
  • 87.86 (n)
oppossum
(Monodelphis domestica)
Mammalia CYP26A1 34
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves CYP26A1 33 34
  • 77.85 (n)
lizard
(Anolis carolinensis)
Reptilia CYP26A1 34
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cyp26a1 33
  • 67.85 (n)
African clawed frog
(Xenopus laevis)
Amphibia LOC398094 33
zebrafish
(Danio rerio)
Actinopterygii cyp26a1 33 34
  • 65.85 (n)
fruit fly
(Drosophila melanogaster)
Insecta Cyp313a1 34
  • 20 (a)
ManyToMany
Cyp313a2 34
  • 20 (a)
ManyToMany
Cyp313a3 34
  • 20 (a)
ManyToMany
Cyp313a4 34
  • 20 (a)
ManyToMany
Cyp313a5 34
  • 20 (a)
ManyToMany
Cyp313b1 34
  • 19 (a)
ManyToMany
Cyp318a1 34
  • 15 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ERG11 34
  • 20 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons CYP716A2 33
  • 44.56 (n)
rice
(Oryza sativa)
Liliopsida Os07g0520300 33
  • 45.49 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5303 34
  • 33 (a)
ManyToMany
-- 34
  • 31 (a)
ManyToMany
Species where no ortholog for CYP26A1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CYP26A1 Gene

ENSEMBL:
Gene Tree for CYP26A1 (if available)
TreeFam:
Gene Tree for CYP26A1 (if available)

Paralogs for CYP26A1 Gene

Paralogs for CYP26A1 Gene

(3) SIMAP similar genes for CYP26A1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CYP26A1: view

Variants for CYP26A1 Gene

Sequence variations from dbSNP and Humsavar for CYP26A1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs777202473 untested 93,075,866(+) AGGAC(A/G)CGAAA reference, missense
rs1001022495 -- 93,075,156(+) CATGA(A/T)GGCGC reference, missense
rs1001248055 -- 93,076,482(+) ACGTC(G/T)GCTGG intron-variant
rs1001302064 -- 93,076,251(+) TCCAA(A/G)GGCAT intron-variant
rs1002106717 -- 93,072,440(+) CGCAG(A/G)TGCGT upstream-variant-2KB

Variation tolerance for CYP26A1 Gene

Residual Variation Intolerance Score: 10% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.58; 44.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CYP26A1 Gene

Human Gene Mutation Database (HGMD)
CYP26A1
The Human Cytochrome P450 Allele Nomenclature Database
CYP26A1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CYP26A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CYP26A1 Gene

Disorders for CYP26A1 Gene

MalaCards: The human disease database

(7) MalaCards diseases for CYP26A1 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
caudal regression syndrome
  • caudal dysplasia
mixed germ cell cancer
  • mixed germ cell neoplasm
keratomalacia
  • night blindness
leukemia, acute promyelocytic, somatic
  • leukemia, acute promyelocytic
ras-associated autoimmune leukoproliferative disorder
  • ras-associated autoimmune lymphoproliferative syndrome type iv, somatic
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CYP26A1

Genetic Association Database (GAD)
CYP26A1
Human Genome Epidemiology (HuGE) Navigator
CYP26A1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CYP26A1
genes like me logo Genes that share disorders with CYP26A1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CYP26A1 Gene

Publications for CYP26A1 Gene

  1. cDNA cloning of human retinoic acid-metabolizing enzyme (hP450RAI) identifies a novel family of cytochromes P450. (PMID: 9228017) White JA … Petkovich M (The Journal of biological chemistry 1997) 2 3 4 22 60
  2. Human retinoic acid (RA) 4-hydroxylase (CYP26) is highly specific for all-trans-RA and can be induced through RA receptors in human breast and colon carcinoma cells. (PMID: 9716180) Sonneveld E … van der Saag PT (Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1998) 3 4 22 60
  3. Expression of cytochrome P450RAI (CYP26) in human fetal hepatic and cephalic tissues. (PMID: 9826557) Trofimova-Griffin ME … Juchau MR (Biochemical and biophysical research communications 1998) 3 4 22 60
  4. Identification of Tazarotenic Acid as the First Xenobiotic Substrate of Human Retinoic Acid Hydroxylase CYP26A1 and CYP26B1. (PMID: 26937021) Foti RS … Douguet D (The Journal of pharmacology and experimental therapeutics 2016) 3 4 60
  5. Biological, clinical and population relevance of 95 loci for blood lipids. (PMID: 20686565) Teslovich TM … Kathiresan S (Nature 2010) 3 45 60

Products for CYP26A1 Gene

Sources for CYP26A1 Gene

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