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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CYP26A1 Gene

protein-coding GIFtS: 64
GCID: GC10P094823

cytochrome P450, family 26, subfamily A, polypeptide 1

(Previous names: cytochrome P450, subfamily XXVIA, polypeptide 1 )

Explore 39 diseases affiliated with
CYP26A1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Cytochrome P450, Family 26, Subfamily A, Polypeptide 1¹ ²		Cytochrome P450RAI² ³
CYP26¹ ² ³		Retinoic Acid 4-Hydroxylase² ³
P450RAI1¹ ² ³		Retinoic Acid-Metabolizing Cytochrome² ³
CP26¹ ²		HP450RAI¹
P450RAI¹ ²		Cytochrome P450 26A1²
Cytochrome P450, Subfamily XXVIA, Polypeptide 1¹ ²		P450, Retinoic Acid-Inactivating, 1²
Cytochrome P450 Retinoic Acid-Inactivating 1² ³		EC 1.14.-.-³

External Ids:	HGNC: 2603¹	Entrez Gene: 1592²	Ensembl: ENSG00000095596⁷	OMIM: 602239⁵	UniProtKB: O43174³

Export aliases for CYP26A1 gene to outside databases

Previous GC identifers: GC10P093726 GC10P094066 GC10P094953 GC10P094486 GC10P094497 GC10P088460

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CYP26A1:

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are

monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and

other lipids. This endoplasmic reticulum protein acts on retinoids, including all-trans-retinoic acid (RA), with both

4-hydroxylation and 18-hydroxylation activities. This enzyme regulates the cellular level of retinoic acid which is

involved in regulation of gene expression in both embryonic and adult tissues. Two alternatively spliced transcript

variants of this gene, which encode the distinct isoforms, have been reported. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CP26A_HUMAN, O43174

Function: Plays a key role in retinoic acid metabolism. Acts on retinoids, including all-trans-retinoic acid (RA) and

its stereoisomer 9-cis-RA. Capable of both 4-hydroxylation and 18-hydroxylation. Responsible for generation of several

hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA and 18-OH-RA

summary for CYP26A1:

Cytochrome P450 (CYP450) enzymes are a diverse group of catalysts that contains 57 members in humans. CYPs

are usually membrane-bound and are localized to the inner mitochondrial or endoplasmic reticular membrane.

CYPs have oxygenase activity and commonly catalyze redox reactions, involving the oxidation of the substrate

and reduction of water. This group of enzymes contain a heme ion within the active site, which is essential

for catalytic activity. CYPs have been found in all organisms tested and are ubiquitously expressed. They

are found at high levels in the liver, where they have an important role in metabolism of drugs and

endogenous toxic compounds (for example bilirubin). Most CYPs can metabolize numerous substrates and this

accounts for their major role in drug interactions. CYPs also have functions in steroid hormone synthesis,

cholesterol synthesis and vitamin D metabolism.

Gene Wiki entry for CYP26A1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000010.10 NC_018921.1 NT_030059.13

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CYP26A1 gene promoter:
NRSF form 1 NRSF form 2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CYP26A1 promoter sequence

Search SABiosciences Chromatin IP Primers for CYP26A1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CYP26A1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q23-q24 Ensembl cytogenetic band: 10q23.33 HGNC cytogenetic band: 10q23-q24

CYP26A1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CYP26A1 gene location

GeneLoc information about chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10P094823: view genomic region (about GC identifiers)

Start:	94,833,232 bp from pter	End:	94,837,647 bp from pter
Size:	4,416 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CP26A_HUMAN, O43174 (See protein sequence)

Recommended Name: Cytochrome P450 26A1

Size: 497 amino acids; 56199 Da

Cofactor: Heme group (By similarity)

Subcellular location: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral

membrane protein

Secondary accessions: B3KNI4 Q5VXH9 Q5VXI0

Alternative splicing: 2 isoforms: O43174-1 O43174-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CYP26A1: NX_O43174

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O43174

CYP26A1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_000774.2 NP_476498.1

ENSEMBL proteins:

ENSP00000360586 ENSP00000224356 ENSP00000377695

Reactome Protein details: O43174
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	Uscn Proteins for CYP26A1

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005789	endoplasmic reticulum membrane	TAS	--
GO:0005792	microsome	--	--

CYP26A1 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for CYP26A1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CYP26A1 for domains About GeneDecksing

3 InterPro domains/families:

IPR001128 Cyt_P450

IPR017972 Cyt_P450_CS

IPR002403 Cyt_P450_E_grp-IV

Graphical View of Domain Structure for InterPro Entry O43174

ProtoNet protein and cluster: O43174

1 Blocks protein family: IPB002403 E-class P450 group IV signature

UniProtKB/Swiss-Prot: CP26A_HUMAN, O43174

Similarity: Belongs to the cytochrome P450 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: CP26A_HUMAN, O43174

Function: Plays a key role in retinoic acid metabolism. Acts on retinoids, including all-trans-retinoic acid (RA) and

its stereoisomer 9-cis-RA. Capable of both 4-hydroxylation and 18-hydroxylation. Responsible for generation of several

hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA and 18-OH-RA

Induction: By retinoic acid

Genatlas biochemistry entry for CYP26A1:

cytochrome p450,family XXVI,involved in extrahepatic metabolism of retinoic acid

Enzyme Number (IUBMB): EC 1.14.-.-¹

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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYP26A1

Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001972	retinoic acid binding	IDA	10823918
GO:0004497	monooxygenase activity	--	--
GO:0005506	iron ion binding	IEA	--
GO:0008401	retinoic acid 4-hydroxylase activity	IDA	9228017
GO:0009055	electron carrier activity	IEA	--

CYP26A1 for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-outs for CYP26A1: Cyp26a1^tm1.1Ptk Cyp26a1^tm1.1Hmd
     14 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Cyp26a1):

cardiovascular system	cellular	craniofacial	digestive/alimentary	embryogenesis
growth/size	limbs/digits/tail	mortality/aging	nervous system	no phenotypic analysis
normal	renal/urinary system	reproductive system	skeleton

CYP26A1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Cytochrome P450 - arranged by substrate type

	Cytochrome P450 - arranged by substrate type	1.00			cytochrome P450	0.73
	Phase 1 - Functionalization of compounds	0.74

Biological oxidations

Biological oxidations

1.00

metapathway biotransformation

0.41

Metabolism

Metabolism

1.00

Nuclear receptors in lipid metabolism and toxicity

Nuclear receptors in lipid metabolism and toxicity

1.00

Adipogenesis

Adipogenesis

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

5 BioSystems Pathways for CYP26A1

	Vitamin A and carotenoid metabolism
	cytochrome P450
	Adipogenesis
	Nuclear receptors in lipid metabolism and toxicity
	metapathway biotransformation

5 Reactome Pathways for CYP26A1

	Cytochrome P450 - arranged by substrate type
	Metabolism
	Biological oxidations
	Phase 1 - Functionalization of compounds
	Vitamins

1 Kegg Pathway (Kegg details for CYP26A1):

Retinol metabolism

CYP26A1 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for CYP26A1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/53 Interacting proteins for CYP26A1 (ENSP00000224356⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 53)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ADH1A	ENSP00000209668⁴	STRING: ENSP00000209668
ADH4	ENSP00000265512⁴	STRING: ENSP00000265512
ADH5	ENSP00000296412⁴	STRING: ENSP00000296412
ADH6	ENSP00000378359⁴	STRING: ENSP00000378359
ADH7	ENSP00000209665⁴	STRING: ENSP00000209665

About this table

Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006766	vitamin metabolic process	TAS	--
GO:0006805	xenobiotic metabolic process	TAS	--
GO:0007417	central nervous system development	IEA	--
GO:0008152	metabolic process	TAS	9228017
GO:0009952	anterior/posterior pattern specification	IEA	--

CYP26A1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CYP26A1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for CYP26A1 available from Tocris Bioscience About this table

Compound	Action	CAS #
Liarozole hydrochloride	Blocks retinoic acid metabolism	[145858-50-0]

1 HMDB Compound for CYP26A1 About this table

Compound	Synonyms	CAS #	PubMed Ids
Heme	(protoporphyrinato)iron (see all 19)	14875-96-8	--

4 DrugBank Compounds for CYP26A1 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Acitretin	--	55079-83-9	enzyme	substrate	19934256
Etretinate	--	54350-48-0	enzyme	substrate	19934256
Ketoconazole	2% (see all 6)	65277-42-1	enzyme	inhibitor	19934256
Vitamin A	[11,12-3H]-Retinol (see all 18)	68-26-8	enzyme	inducer	19934256

10 Novoseek chemical compound relationships for CYP26A1 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
liarozole	89.5	10	8757760 (4), 9716180 (1), 15597402 (1), 19294396 (1) (see all 5)
retinoic acid	86.8	272	16194896 (11), 11994980 (8), 11302942 (7), 9716180 (5) (see all 61)
retinoid	84.6	19	19294396 (3), 9564181 (1), 11302942 (1), 9740237 (1) (see all 12)
am 580	83.4	7	11302942 (2), 11690641 (2)
retinaldehyde	77.8	1	20063272 (1)
ttab	71.2	2	10953040 (2)
vitamin a	71	17	14704332 (3), 8757760 (2), 19016711 (1), 16194896 (1) (see all 7)
n-(4-hydroxyphenyl)retinamide	52.2	1	15448016 (1)
isotretinoin	46.8	4	19525031 (2), 10545224 (1)
ketoconazole	45.6	2	10874126 (1), 14532297 (1)

Search CenterWatch for drugs/clinical trials and news about CYP26A1 / CP26A

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CYP26A1 gene (2 alternative transcripts):

NM_000783.3 NM_057157.2

Unigene Cluster for CYP26A1:

Cytochrome P450, family 26, subfamily A, polypeptide 1

Hs.150595 [show with all ESTs]

Unigene Representative Sequence: AK027560

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000371531(uc001kik.1) ENST00000224356 ENST00000394139(uc001kil.2)

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Additional cDNA sequence:

AF005418.1 AK027560.1 AK075374.1

3 DOTS entries:

DT.310567 DT.91756297 DT.100680587

24/31 AceView cDNA sequences (see all 31):

BX281858 BM930903 BM684420 CR598753 CR604765 AK075374 NM_057157 NM_000783

BM706435 BQ011150 BM797145 AL539668 AF005418 AW513600 R45372 BX955261

BQ011865 BQ010588 AL532445 AI863962 AK027560 BF055367 AI082714 AI004222

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for CYP26A1 (see all 6) About this scheme

ExUns:	1	^	2a	·	2b	^	3a	·	3b	^	4a	·	4b	^	5a	·	5b	^	6a	·	6b	^	7a	·	7b	·	7c	^	8a	·	8b	·	8c
SP1:			-		-														-				-
SP2:																			-				-
SP3:											-								-				-
SP4:
SP5:																							-

ECgene alternative splicing isoforms for CYP26A1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CYP26A1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGGAAATCTG

About this image

CYP26A1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

3 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Head Mesenchyme

Branchial Arch 1

Paraxial Mesoderm Cells

Bone, Skeletal Muscle

Liver

Liver Lobule

Perivenous Hepatocytes

Liver

Kidney

S-shaped Body

Kidney

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 8 LifeMap Cells

Name

Category

Extra-embryonic endoderm cells (Fetal Stem / Progenitor Cell)

Extraembryonic Tissues

ES04(HES-4) (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

Line H9 (WA09) (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

Mesendoderm-like cells (Generation of mesend...)

Definitive endoderm-like cells (Generation of mesend...)

Definitive endoderm-like cells (A scalable, suspensi...)

Definitive Endoderm (Generation of beta c...)

HyStem+BMP4-induced MEL2 cells (HyStem+BMP4 inductio...)

Bone

See CYP26A1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CYP26A1

SOURCE GeneReport for Unigene cluster: Hs.150595

UniProtKB/Swiss-Prot: CP26A_HUMAN, O43174

Tissue specificity: Highest levels in adult liver, heart, pituitary gland, adrenal gland, placenta and regions of the

brain

SABiosciences Expression via Pathway-Focused PCR Arrays including CYP26A1:

Notch Signaling Targets in human mouse rat

Drug Metabolism: Phase I Enzymes in human mouse rat

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for CYP26A1 gene from 7/17 species (see all 17) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Cyp26a1^{1 , 5}	cytochrome P450, family 26, subfamily a, polypeptide more^{1, 5}	89.81(n)¹ 93.96(a)¹		19 (32.36 cM)⁵ 13082¹ NM_007811.2¹ NP_031837.2¹ 37697808⁵
chicken (Gallus gallus)	Aves	CYP26A1¹	cytochrome P450, family 26, subfamily A, polypeptide more	77.85(n) 80.28(a)		408183 NM_001001129.1 NP_001001129.1
lizard (Anolis carolinensis)	Reptilia	CYP26A1⁶	--	76(a)	1 ↔ 1	GL343219.1(2208917-2227327)
African clawed frog (Xenopus laevis)	Amphibia	LOC398094²	retinoic acid converting enzyme	73.32(n)		AF057566.1
zebrafish (Danio rerio)	Actinopterygii	cyp26a1²	cytochrome P450, subfamily XXVIA, polypeptide 1	73.14(n)		30381 U68234.1
thale cress (Arabidopsis thaliana)	eudicotyledons	CYP716A2¹	cytochrome P450, family 716, subfamily A, polypeptide more	45.13(n) 35.04(a)		833611 NM_123005.1 NP_198463.1
rice (Oryza sativa)	Liliopsida	Os07g0520300¹	hypothetical protein	45.51(n) 31.62(a)		4343399 NM_001066336.1 NP_001059801.1

ENSEMBL Gene Tree for CYP26A1 (if available)
TreeFam Gene Tree for CYP26A1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CYP26A1 gene

CYP51A1² CYP26B1² CYP26C1²

3 SIMAP similar genes for CYP26A1 using alignment to 1 protein entry: CP26A_HUMAN:

DKFZp686G0638 CYP26B1 CYP26C1

CYP26A1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 10 pos	Sequence	#	AA Chg	Type	More	#	Pop	Total sample
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs66526527^1,2	C,	--	88459301(+)	`NNNNCC/TGGGAT`	2	--	us2k¹		4	WA NA EA	360
rs116582463^1,2	C,F,	--	88459498(+)	`TGGAGA/CGTCGC`	2	--	us2k¹		1	WA	118
rs75001704^1,2	F,	--	88459629(+)	`GACGCC/TTTCCA`	2	--	us2k¹		1	WA	118
rs115916166^1,2	C,F,	--	88459943(+)	`AGCCCT/GGAGTT`	2	--	us2k¹		1	WA	118
rs3928850^1,2	C,F,	--	88460305(+)	`AAGGAC/ACCCCT`	2	--	us2k¹ trp³		3	NA	136
rs72558182^1,2	F,	--	88460941(+)	`GAGGCG/AGGCAG`	2	--	ut5¹ us2k¹		1	EA	120
rs74151825^1,2	C,	--	88461969(+)	`GTGCCA/GTGTGT`	2	--	int¹		3	WA EA	240
rs73319394^1,2	C,	--	88462138(+)	`CAGCAG/ACCTGG`	4	/N /S	mis¹		1	WA	2
rs75053982^1,2	C,F,	--	88462601(+)	`NNNNAG/ACAGCT`	2	--	int¹		1	EU	571
rs73319398^1,2	C,F,	--	88462854(+)	`NNNNAA/CAGAAC`	2	--	int¹		3	NA WA	122

HapMap Linkage Disequilibrium report for CYP26A1 (94833232 - 94837647 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CYP26A1: --
Human Gene Mutation Database (HGMD): CYP26A1

Locus Specific Mutation Databases (LSDB): CYP26A1

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CYP26A1

DNA2.0 Custom Variant and Variant Library Synthesis for CYP26A1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CYP26A1 for disorders           About GeneDecksing

OMIM gene information: 602239    OMIM disorders: --

20/39 diseases for CYP26A1 (see all 39):    About MalaCards

open-angle glaucoma caudal regression syndrome primary open angle glaucoma retinol binding protein

neural tube defect cholesterol imperforate anus congenital diaphragmatic hernia

spina bifida ankylosing spondylitis acute promyelocytic leukemia glaucoma

hernia digeorge syndrome acute myeloid leukemia lyme disease

myeloid leukemia spondylitis squamous cell carcinoma urethritis

3 diseases from the University of Copenhagen DISEASES database for CYP26A1:

Imperforate anus Lyme disease Spina bifida

9 Novoseek disease relationships for CYP26A1 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
leukemia promyelocytic acute	61.5	2	16194896 (2)
carcinoma embryonal	45.3	2	18502188 (1), 10479456 (1)
vitamin a deficiency	39.1	2	14704332 (1)
promyelocytic leukemia	34.8	6	11994980 (3), 15896339 (2)
hnscc	34.7	2	11309353 (2)
leukemia	0	4	15896339 (3)
breast cancer	0	2	9716180 (1), 11025452 (1)
tumors	0	7	15448016 (2), 9228017 (1), 15597402 (1)
cancer	0	1	9857269 (1)

Genetic Association Database (GAD): CYP26A1
Human Genome Epidemiology (HuGE) Navigator: CYP26A1 (9 documents)

Export disorders for CYP26A1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for CYP26A1 gene, integrated from 9 sources (see all 102):
(articles sorted by number of sources associating them with CYP26A1)

Utopia: connect your pdf to the dynamic
world of online information

cDNA cloning of human retinoic acid-metabolizing enzyme (hP450RAI) identifies a novel family of cytochromes P450. (PubMed id 9228017)^{1, 2, 3, 9} White J.A.... Petkovich M. (1997)
Expression of cytochrome P450RAI (CYP26) in human fetal hepatic and cephalic tissues. (PubMed id 9826557)^{1, 2, 9} Trofimova-Griffin M.E. and Juchau M.R. (1998)
Human retinoic acid (RA) 4-hydroxylase (CYP26) is highly specific for all-trans-RA and can be induced through RA receptors in human breast and colon carcinoma cells. (PubMed id 9716180)^{1, 2, 9} Sonneveld E.... van der Saag P.T. (1998)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
P450RAI (CYP26A1) maps to human chromosome 10q23-q24 and mouse chromosome 19C2-3. (PubMed id 9521883)^{1, 3} White J.A....Petkovich M. (1998)
Regulation of a highly specific retinoic acid-4-hydroxylase (CYP26A1) enzyme and all-trans-retinoic acid metabolism in human intestinal, liver, endothelial, and acute promyelocytic leukemia cells. (PubMed id 16194896)^{1, 9} Ozpolat B....Lopez-Berestein G. (2005)
The discovery of new coding alleles of human CYP26A1 that are potentially defective in the metabolism of all-trans retinoic acid and their assessment in a recombinant cDNA expression system. (PubMed id 17460545)^{1, 9} Lee S.J....Goldstein J.A. (2007)
CYP26, a novel mammalian cytochrome P450, is induced by retinoic acid and defines a new family. (PubMed id 9228041)^{1, 9} Ray W.J....Gottlieb D.I. (1997)
Homology model of human retinoic acid metabolising enzyme cytochrome P450 26A1 (CYP26A1): active site architecture and ligand binding. (PubMed id 17059167)^{1, 9} Gomaa M.S....Brancale A. (2006)
A novel human cytochrome P450, CYP26C1, involved in metabolism of 9- cis and all-trans isomers of retinoic acid. (PubMed id 14532297)^{1, 9} Taimi M.... Petkovich M. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 1592	HGNC: 2603	AceView: CYP26A1	Ensembl:ENSG00000095596	euGenes: HUgn1592
ECgene: CYP26A1	Kegg: 1592	H-InvDB: CYP26A1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for CYP26A1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for CYP26A1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for CYP26A1 gene:
Search GeneIP for patents involving CYP26A1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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CYP26A1 Gene

cytochrome P450, family 26, subfamily A, polypeptide 1

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CYP26A1 Gene

cytochrome P450, family 26, subfamily A, polypeptide 1

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