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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CYP24A1 Gene

protein-coding GIFtS: 69
GCID: GC20M052769

Cytochrome P450, Family 24, Subfamily A, Polypeptide 1

(Previous names: cytochrome P450, subfamily XXIV (vitamin D 24-hydroxylase))
(Previous symbol: CYP24)

40 related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Cytochrome P450, Family 24, Subfamily A, Polypeptide 1¹ ²		1,25-Dihydroxyvitamin D(3) 24-Hydroxylase, Mitochondrial²
CYP24¹ ² ³ ⁵		CP24²
Cytochrome P450, Subfamily XXIV (Vitamin D 24-Hydroxylase)¹ ²		HCAI²
Cytochrome P450 24A1² ³		P450-CC24²
Cytochrome P450-CC24² ³		Exo-Mitochondrial Protein²
Vitamin D(3) 24-Hydroxylase² ³		Vitamin D 24-Hydroxylase²
24-OHase² ³		EC 1.14.13.126³
1,25-@Dihydroxyvitamin D3 24-Hydroxylase²

External Ids:	HGNC: 2602¹	Entrez Gene: 1591²	Ensembl: ENSG00000019186⁷	OMIM: 126065⁵	UniProtKB: Q07973³

Export aliases for CYP24A1 gene to outside databases

Previous GC identifers: GC20M052458 GC20M053408 GC20M053455 GC20M052203 GC20M049516

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CYP24A1 Gene:

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are

monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and

other lipids. This mitochondrial protein initiates the degradation of 1,25-dihydroxyvitamin D3, the physiologically

active form of vitamin D3, by hydroxylation of the side chain. In regulating the level of vitamin D3, this enzyme

plays a role in calcium homeostasis and the vitamin D endocrine system. Alternatively spliced transcript variants

encoding different isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for CYP24A1 Gene:

CYP24A1 (cytochrome P450, family 24, subfamily A, polypeptide 1) is a protein-coding gene. Diseases associated with CYP24A1 include hypercalcemia, infantile, and osteomalacia, and among its related super-pathways are Vitamin D2 (ergocalciferol) metabolism and Cytochrome P450 - arranged by substrate type. GO annotations related to this gene include electron carrier activity and heme binding. An important paralog of this gene is CYP11A1.

UniProtKB/Swiss-Prot: CP24A_HUMAN, Q07973

Function: Has a role in maintaining calcium homeostasis. Catalyzes the NADPH-dependent 24-hydroxylation of calcidiol

(25-hydroxyvitamin D(3)) and calcitriol (1-alpha,25-dihydroxyvitamin D(3)). The enzyme can perform up to 6 rounds of

hydroxylation of calcitriol leading to calcitroic acid. It also shows 23-hydroxylating activity leading to

1-alpha,25-dihydroxyvitamin D(3)-26,23-lactone as end product

Gene Wiki entry for CYP24A1 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000020.10 NT_011362.10 NC_018931.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CYP24A1 gene promoter:
AML1a AP-1 ATF-2 FOXD3 YY1 C/EBPalpha CREB AREB6 deltaCREB c-Jun
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CYP24A1 promoter sequence

Search SABiosciences Chromatin IP Primers for CYP24A1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CYP24A1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13 Ensembl cytogenetic band: 20q13.2 HGNC cytogenetic band: 20q13.2-q13.3

CYP24A1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CYP24A1 gene location

GeneLoc information about chromosome 20 GeneLoc Exon Structure

GeneLoc location for GC20M052769: view genomic region (about GC identifiers)

Start:	52,769,988 bp from pter	End:	52,790,516 bp from pter
Size:	20,529 bases	Orientation:	minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CP24A_HUMAN, Q07973 (See protein sequence)

Recommended Name: 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial precursor

Size: 514 amino acids; 58875 Da

Cofactor: Heme group (By similarity)

Subcellular location: Mitochondrion

Secondary accessions: Q15807 Q32ML3

Alternative splicing: 2 isoforms: Q07973-1 Q07973-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CYP24A1: NX_Q07973

Explore proteomics data for CYP24A1 at MOPED

Post-translational modifications:

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_Q07973

CYP24A1 Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins (2 alternative transcripts):

NP_000773.2 NP_001122387.1

ENSEMBL proteins:

ENSP00000216862 ENSP00000379285 ENSP00000379284

Reactome Protein details: Q07973
Human Recombinant Protein Products for CYP24A1:

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	Browse ProSpec Recombinant Proteins
	Cloud-Clone Corp. Proteins for CYP24A1

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005739	mitochondrion	--	--
GO:0005743	mitochondrial inner membrane	TAS	--

CYP24A1 for ontologies About GeneDecksing

CYP24A1 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of CYP24A1
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Assay Products for CYP24A1:

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	GenScript Custom Assay Services for CYP24A1
	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for CYP24A1 Cloud-Clone Corp. CLIAs for CYP24A1

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HGNC Gene Families:

CYP: Cytochrome P450s

IUPHAR Guide to PHARMACOLOGY protein family classification: CYP24A1

CYP24, CYP26 and CYP27 families

3 InterPro protein domains:

IPR001128 Cyt_P450

IPR017972 Cyt_P450_CS

IPR002401 Cyt_P450_E_grp-I

Graphical View of Domain Structure for InterPro Entry Q07973

ProtoNet protein and cluster: Q07973

1 Blocks protein domain: IPB002949 CC24 mitochondrial P450 signature

UniProtKB/Swiss-Prot: CP24A_HUMAN, Q07973

Similarity: Belongs to the cytochrome P450 family

CYP24A1 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: CP24A_HUMAN, Q07973

Function: Has a role in maintaining calcium homeostasis. Catalyzes the NADPH-dependent 24-hydroxylation of calcidiol

(25-hydroxyvitamin D(3)) and calcitriol (1-alpha,25-dihydroxyvitamin D(3)). The enzyme can perform up to 6 rounds of

hydroxylation of calcitriol leading to calcitroic acid. It also shows 23-hydroxylating activity leading to

1-alpha,25-dihydroxyvitamin D(3)-26,23-lactone as end product

Catalytic activity: Calcitriol + NADPH + O(2) = calcitetrol + NADP(+) + H(2)O

Catalytic activity: Calcidiol + NADPH + O(2) = secalciferol + NADP(+) + H(2)O

Enzyme Number (IUBMB): EC 1.14.13.126¹

Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004497	monooxygenase activity	--	--
GO:0005506	iron ion binding	IEA	--
GO:0008403	25-hydroxycholecalciferol-24-hydroxylase activity	IEA	--
GO:0009055	electron carrier activity	IEA	--
GO:0016491	oxidoreductase activity	NAS	7632726

CYP24A1 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for CYP24A1:

Cell cycle / mitosis defect

6 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Cyp24a1):

growth/size	homeostasis/metabolism	mortality/aging	renal/urinary system	reproductive system
skeleton

CYP24A1 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Cyp24a1^tm1Star for CYP24A1

inGenious Targeting Laboratory - Custom generated mouse model solutions for CYP24A1

inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CYP24A1

miRNA Products:		miRTarBase miRNAs that target CYP24A1: hsa-mir-125b (MIRT004408)


		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CYP24A1
		8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate CYP24A1 (see all 16):
		hsa-miR-3671 hsa-miR-30c hsa-miR-125a-5p hsa-miR-571 hsa-miR-30d hsa-miR-3144-3p hsa-miR-374a* hsa-miR-144

		SwitchGear 3'UTR luciferase reporter plasmid: CYP24A1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene clones in human, mouse for CYP24A1 (see all 7) OriGene ORF clones in mouse, rat for CYP24A1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CYP24A1
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYP24A1

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for CYP24A1 About (see all 9)

See pathways by source

SuperPath

Contained pathways About

Vitamin D2 (ergocalciferol) metabolism

	Vitamin D2 (ergocalciferol) metabolism	0.40			Vitamin D (calciferol) metabolism	0.36
	Vitamin D synthesis	0.40			Vitamins	0.33

Cytochrome P450 - arranged by substrate type

	Cytochrome P450 - arranged by substrate type	0.75			Phase 1 - Functionalization of compounds	0.74
	cytochrome P450	0.75

Metabolism

	Metabolism	0.40			Metabolism of lipids and lipoproteins	0.34
	Metabolic pathways	0.40

Biological oxidations

Biological oxidations

0.55

metapathway biotransformation

0.41

Metabolism of steroid hormones and vitamin D

Metabolism of steroid hormones and vitamin D

1.00

Steroid hormones

1.00

Pathways by source See SuperPaths
Show all pathways

2 EMD Millipore Pathways for CYP24A1

	Transcription Role of VDR in regulation of genes involved in osteoporosis
	Vitamin D2 (ergocalciferol) metabolism

2 GeneGo (Thomson Reuters) Pathways for CYP24A1

	Transcription Role of VDR in regulation of genes involved in osteoporosis
	Vitamin D2 (ergocalciferol) metabolism

4 BioSystems Pathways for CYP24A1

	Vitamin D synthesis
	cytochrome P450
	Nuclear receptors in lipid metabolism and toxicity
	metapathway biotransformation

5/9 Reactome Pathways for CYP24A1 (see all 9)

	Cytochrome P450 - arranged by substrate type
	Metabolism
	Steroid hormones
	Vitamin D (calciferol) metabolism
	Metabolism of steroid hormones and vitamin D

3 Kegg Pathways (Kegg details for CYP24A1):

	Steroid biosynthesis
	Metabolic pathways
	MicroRNAs in cancer

CYP24A1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CYP24A1

STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

5/6 Interacting proteins for CYP24A1 (Q07973^{2, 3} ENSP00000216862⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 6)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CITED1	Q99966³, ENSP00000388548⁴	I2D: score=1 STRING: ENSP00000388548
TP53	P04637³, ENSP00000269305⁴	I2D: score=1 STRING: ENSP00000269305
VDR	P11473³, ENSP00000229022⁴	I2D: score=1 STRING: ENSP00000229022
TARBP2	Q15633³	I2D: score=2
UBC	ENSP00000344818⁴	STRING: ENSP00000344818

About this table

Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001649	osteoblast differentiation	IEP	17023519
GO:0006766	vitamin metabolic process	TAS	--
GO:0006805	xenobiotic metabolic process	TAS	--
GO:0008202	steroid metabolic process	TAS	--
GO:0033280	response to vitamin D	IDA	16720713

CYP24A1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, IUPHAR, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CYP24A1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CYP24A1 (CP24A)

9 HMDB Compounds for CYP24A1 About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcidiol	25-Hydroxyvitamin D3 (see all 11)	19356-17-3	--
Calcitriol	(3b,5Z,7E)-9,10-Secocholesta-5,7,10(19)-trienetriol (see all 19)	32222-06-3	--
Calcium	Ca (see all 2)	7440-70-2	--
Ercalcitriol	1,25-Dihydroxycalciferol (see all 7)	60133-18-8	--
Ergocalciferol	(+)-Vitamin D2 (see all 72)	50-14-6	--
Heme	(protoporphyrinato)iron (see all 19)	14875-96-8	--
NADP	Adenine-nicotinamide dinucleotide phosphate (see all 18)	53-59-8	--
NADPH	2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide (see all 23)	53-57-6	--
Vitamin D3	(+)-Vitamin D3 (see all 32)	67-97-0	--

6 DrugBank Compounds for CYP24A1 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Ergocalciferol	Synthetic Vitamin D (see all 2)	50-14-6	enzyme	substrate	15574355 15764712 16816472 11686044 16516540
Calcitriol	1,25-(OH)₂D3 (see all 2)	32222-06-3	enzyme	substrate inducer	20619365 19934256
Calcidiol	Calcifediol (see all 4)	19356-17-3	enzyme	substrate	19934256
Calcipotriol	--	112965-21-6	enzyme	substrate	16886668
Corticotropin	ACTH (see all 5)	9002-60-2	enzyme	inducer	19920212
Paricalcitol	--	131918-61-1	enzyme	substrate	15733015

10/29 Novoseek inferred chemical compound relationships for CYP24A1 gene (see all 29) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
calcitroic acid	91.3	5	11686044 (1), 15574355 (1), 17646648 (1), 16816472 (1) (see all 5)
vitamin d	90.9	152	11179754 (4), 19237542 (3), 14760115 (3), 14648702 (2) (see all 81)
calcitriol	90.9	96	17368180 (6), 16708384 (4), 12027461 (4), 12914530 (3) (see all 40)
1,25 dihydroxy vitamin d3	90.6	38	15225756 (3), 16457885 (2), 19922790 (2), 15836435 (2) (see all 24)
25-hydroxyvitamin d	89.7	42	11686044 (2), 16600026 (2), 11012668 (2), 17395559 (2) (see all 27)
1,24,25-trihydroxyvitamin d3	88.2	3	12504896 (1), 9165006 (1)
bm 15766	82.5	4	16598763 (2), 16824767 (2)
24,25-dihydroxyvitamin d3	82.3	3	12504896 (1), 9165006 (1)
paricalcitol	69.8	1	16371233 (1)
7-dehydrocholesterol	61.5	3	16598763 (1), 16824767 (1)

Search CenterWatch for drugs/clinical trials and news about CYP24A1 / CP24A

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CYP24A1 gene (2 alternative transcripts):

NM_000782.4 NM_001128915.1

Unigene Cluster for CYP24A1:

Cytochrome P450, family 24, subfamily A, polypeptide 1

Hs.89663 [show with all ESTs]

Unigene Representative Sequence: NM_000782

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000216862(uc002xwu.1 uc002xwv.2 uc002xww.2) ENST00000395955

ENST00000460643 ENST00000395954 ENST00000487593 ENST00000472970

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		SwitchGear 3'UTR luciferase reporter plasmid: CYP24A1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for CYP24A1
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		Sirion Biotech Custom design and validation of potent shRNA sequences against CYP24A1

Clone Products:		OriGene clones in human, mouse for CYP24A1 (see all 7) OriGene ORF clones in mouse, rat for CYP24A1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): CYP24A1 (NM_000782)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CYP24A1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CYP24A1

Primer Products:		OriGene qPCR primer pairs and template standards for CYP24A1 OriGene qSTAR qPCR primer pairs in human, mouse for CYP24A1
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CYP24A1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CYP24A1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CYP24A1

Additional mRNA sequence:

AY858838.1 BC109083.1 BC109084.1 L13286.1 S67623.1

6 DOTS entries:

DT.99972261 DT.91986788 DT.75108883 DT.311476 DT.75100645 DT.91696137

24/29 AceView cDNA sequences (see all 29):

BM928702 AA877213 AW205073 N20655 BX109503 AW194692 AW206049 BU662901

CD013988 S67623 BF800401 BG401173 N29030 AW237530 NM_000782 L13286

BF356900 AI400154 N21576 AI928330 BI491491 N30976 H82378 AW022457

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for CYP24A1 (see all 6) About this scheme

ExUns:	1a	·	1b	·	1c	^	2a	·	2b	^	3a	·	3b	^	4	^	5	^	6a	·	6b	^	7a	·	7b	^	8	^	9	^	10	^	11a	·	11b	^	12a	·	12b	·	12c	·	12d
SP1:									-		-														-								-				-
SP2:									-		-														-						-		-				-
SP3:																									-								-				-
SP4:
SP5:

ECgene alternative splicing isoforms for CYP24A1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CYP24A1 expression in normal human tissues (normalized intensities) CYP24A1 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: CAATACTTAT

About this image

CYP24A1 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database

5/5 selected tissues (see all 5) fully expand


Eye (Sensory Organs) fully expand to see all 3 entries
Human corneal endothelial cells
retinal progenitor cell e16.5

Kidney (Urinary System)
Metanephric Mesenchyme Cells Metanephric Mesenchyme

Tonsil
tonsil epithelium

Endothelium (Cardiovascular System)
Human corneal endothelial cells

Prostate (Endocrine System)

See CYP24A1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CYP24A1

SOURCE GeneReport for Unigene cluster: Hs.89663

SABiosciences Expression via Pathway-Focused PCR Array including CYP24A1:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for CYP24A1 gene from 6/13 species (see all 13) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Cyp24a1^{1 , 5}	cytochrome P450, family 24, subfamily a, polypeptide more^{1, 5}	81.06(n)¹ 82.88(a)¹		2 (91.91 cM)⁵ 13081¹ NM_009996.3¹ NP_034126.1¹ 170482708⁵
chicken (Gallus gallus)	Aves	CYP24A1¹	cytochrome P450, family 24, subfamily A, polypeptide more	70.93(n) 71.75(a)		395827 NM_204979.1 NP_990310.1
lizard (Anolis carolinensis)	Reptilia	-- --	Uncharacterized protein	77(a) 69(a)	1 ↔ many 1 ↔ many	AAWZ02036255(2048-16669) GL343716.1(170008-188769)
zebrafish (Danio rerio)	Actinopterygii	cyp24a1¹	cytochrome P450, family 24, subfamily A, polypeptide more	66.59(n) 70.33(a)		100004700 NM_001089458.1 NP_001082927.1
fruit fly (Drosophila melanogaster)	Insecta	Cyp12b2¹	CG15077-PA	43.46(n) 28.38(a)		37163 NM_137526.3 NP_611370.2
worm (Caenorhabditis elegans)	Secernentea	cyp-44A1¹	Protein CYP-44A1	41.76(n) 29.84(a)		173936 NM_062651.2 NP_495052.1

ENSEMBL Gene Tree for CYP24A1 (if available)
TreeFam Gene Tree for CYP24A1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CYP24A1 gene

CYP11A1² CYP27A1² CYP11B1² CYP27C1² CYP11B2² CYP27B1²

6 SIMAP similar genes for CYP24A1 using alignment to 1 protein entry: CP24A_HUMAN:

CYP24 CYP27C1 CYP27A1 CYP11B2 CYP11B1 CYP27B1

CYP24A1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 20 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
VAR_066409⁴		Hypercalcemia infantile (HCAI)⁴	--	see VAR_066409	2	R Q	mis⁴		0	--	--	--	--
VAR_066410⁴		Hypercalcemia infantile (HCAI)⁴	--	see VAR_066410	2	E K	mis⁴		0	--	--	--	--
rs6068812^1,2,4	C,F,H	Hypercalcemia infantile (HCAI)⁴ --	52744604(+)	`TGGGTA/GAAGCA`	4	S L	mis¹		13		NS EA NA MN EU	6785
rs114368325^1,2,4	C,F	Hypercalcemia infantile (HCAI)⁴ --	52744644(+)	`AGTCCG/AAGTTG`	4	/R /W	mis¹		2		NA	4724
rs10623012^1,2	C	--	49516610(+)	`AAGAC-/ATGTGAA`	2	--	ut3¹		6		EU EA NA MN CSA	432
rs11086451^1,2	C	--	49519007(+)	`TGTTA-/ATTTAA`	2	--	int¹		0	--	--	--	--
rs56109195^1,2	C,F	--	49531771(+)	`CTTCTT/CTATTT`	2	--	int¹		3		WA NA EA	358
rs6127121^1,2	C	--	49531773(+)	`TCTTTC/ATTTCT`	2	--	int¹		6		WA CSA NA EA	362
rs180800820^1,2		--	49531816(+)	`CCTTCC/GCTCCT`	2	--	int¹		0	--	--	--	--
rs11906937^1,2	C,H	--	49531905(+)	`cttccC/Ttccct`	2	--	int¹ trp³		0	--	--	--	--

HapMap Linkage Disequilibrium report for CYP24A1 (52769988 - 52790516 bp)

Structural Variations
Database of Genomic Variants (DGV) 5 variations for CYP24A1: About this table

Variant ID	Type	Subtype	PubMed ID
esv28399	CNV	Loss	19812545
nsv912946	CNV	Loss	21882294
nsv912945	CNV	Loss	21882294
nsv834010	CNV	Loss	17160897
esv259753	OTHER	Complex	20981092

Human Gene Mutation Database (HGMD): CYP24A1

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CYP24A1 for disorders About GeneDecksing

OMIM gene information: 126065 OMIM disorders: --

UniProtKB/Swiss-Prot: CP24A_HUMAN, Q07973

Hypercalcemia infantile (HCAI) [MIM:143880]: A disorder characterized by abnormally high level of calcium in

the blood, failure to thrive, vomiting, dehydration, and nephrocalcinosis. Note=The disease is caused by mutations

affecting the gene represented in this entry

20/40 diseases for CYP24A1 (see all 40): About MalaCards

hypercalcemia, infantile osteomalacia rickets cytochrome p450

hypercalcemia nephrocalcinosis gigantism renal clear cell carcinoma

rabies osteosarcoma esophageal adenocarcinoma colon cancer

lung adenocarcinoma basal cell carcinoma esophageal cancer thyroid cancer

myeloid leukemia endometriosis type 1 diabetes prostate cancer

1 disease from the University of Copenhagen DISEASES database for CYP24A1:

Rickets

10/24 Novoseek inferred disease relationships for CYP24A1 gene (see all 24) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
rickets	64	2	8266831 (1), 15544953 (1)
rickets hypophosphatemic	57.8	1	16753019 (1)
prostate cancer	40.2	15	12270218 (2), 12485911 (2), 17368180 (2), 15538745 (1) (see all 8)
osteomalacia	36.6	4	16691293 (3), 15630458 (1)
breast cancer	29.8	14	19667160 (2), 19570947 (2), 15225785 (1), 15863722 (1) (see all 8)
cancer	28.4	22	19570947 (3), 16680461 (2), 16180015 (1), 17507873 (1) (see all 13)
colon carcinoma	24.2	3	12027461 (2), 11467853 (1)
colon cancer	18.7	2	11467853 (2)
tumors	16.5	17	16180015 (4), 14585316 (1), 17875655 (1), 12899539 (1) (see all 14)
myeloid leukemia	14	2	10410379 (1), 16457885 (1)

Genetic Association Database (GAD): CYP24A1
Human Genome Epidemiology (HuGE) Navigator: CYP24A1 (31 documents)

Export disorders for CYP24A1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CYP24A1 gene, integrated from 9 sources (see all 259):
(articles sorted by number of sources associating them with CYP24A1)

Utopia: connect your pdf to the dynamic
world of online information

Metabolism of vitamin D3 by cytochromes P450. (PubMed id 15574355)^{2, 7, 9} Sakaki T.... Inouye K. (2005)
Evidence for the activation of 1alpha-hydroxyvitamin D2 by 25-hydroxyvitamin D-24-hydroxylase: delineation of pathways involving 1alpha,24-dihydroxyvitamin D2 and 1alpha,25-dihydroxyvitamin D2. (PubMed id 16516540)^{1, 7, 9} Masuda S....Jones G. (2006)
Association of the vitamin D metabolism gene CYP27B1 with type 1 diabetes. (PubMed id 17606874)^{1, 4, 9} Bailey R....Todd J.A. (2007)
Asthma families show transmission disequilibrium of gene variants in the vitamin D metabolism and signalling pathway. (PubMed id 16600026)^{1, 4, 9} Wjst M....Andre E. (2006)
Human 25-hydroxyvitamin D 24-hydroxylase cytochrome P450 subunit maps to a different chromosomal location than that of pseudovitamin D- deficient rickets. (PubMed id 8266831)^{1, 2, 9} Labuda M.... Glorieux F.H. (1993)
Vitamin D pathway gene variants and prostate cancer r isk. (PubMed id 19454612)^{1, 4, 9} Holt S.K....Stanford J.L. (2009)
Vitamin D-related genes, serum vitamin D concentrations and prostate cancer risk. (PubMed id 19255064)^{1, 4, 9} Ahn J....Hayes R.B. (2009)
Vitamin D pathway gene polymorphisms, diet, and risk of postmenopausal breast cancer: a nested case-control study. (PubMed id 17244366)^{1, 4, 9} McCullough M.L....Calle E.E. (2007)
Mutations in CYP24A1 and idiopathic infantile hypercalcemia. (PubMed id 21675912)^{1, 2} Schlingmann K.P.... Konrad M. (2011)
Genetic risk and a primary role for cell-mediated immu ne mechanisms in multiple sclerosis. (PubMed id 21833088)^{1, 4} ....Compston A. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 1591	HGNC: 2602	AceView: CYP24A1	Ensembl:ENSG00000019186	euGenes: HUgn1591
ECgene: CYP24A1	Kegg: 1591	H-InvDB: CYP24A1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CYP24A1	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for CYP24A1	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for CYP24A1 gene
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Patent Information for CYP24A1 gene:
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GeneCards and IP:
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Cytochrome P450, Family 24, Subfamily A, Polypeptide 1

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CYP24A1 Gene

Cytochrome P450, Family 24, Subfamily A, Polypeptide 1

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