CYP24A1 Gene

Aliases
for CYP24A1 gene

Previous GC identifers: GC20M052458 GC20M053408 GC20M053455 GC20M052203 GC20M049516

Summaries
for CYP24A1 gene

Genomic Views
for CYP24A1 gene

RefSeq DNA sequence:

NC_000020.10  NC_018931.1  NT_011362.10  

SwitchGear Promoter luciferase reporter plasmid: CYP24A1 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CYP24A1

CYP24A1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M052769:  view genomic region     (about GC identifiers)

Proteins
for CYP24A1 gene

Explore the universe of human proteins at neXtProt for CYP24A1: NX_Q07973

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	Novus Biologicals CYP24A1 Protein
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	Browse ProSpec Recombinant Proteins
	Uscn Proteins for CYP24A1

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

	EMD Millipore Mono- and Polyclonal Antibodies for the study of CYP24A1
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	OriGene Antibodies: CYP24A1 OriGene Custom Antibody Services for CYP24A1
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	Novus Biologicals CYP24A1 Antibodies
	Abcam antibodies for CYP24A1
	Uscn Antibodies for CYP24A1
	ThermoFisher Antibodies for CYP24A1

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
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	GenScript Custom Assay Services for CYP24A1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CYP24A1

Protein Domains /
Families
for CYP24A1 gene

ProtoNet protein and cluster: Q07973

Function
for CYP24A1 gene

     Enzyme Number (IUBMB): EC 1.14.13.126¹

     Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

(inferred from 1 allele) (MGI details for Cyp24a1)

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for CYP24A1

miRNA Products:		miRTarBase miRNAs that target CYP24A1: hsa-mir-125b (MIRT004408)
		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CYP24A1
		8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate CYP24A1 (see all 16):
		hsa-miR-3671 hsa-miR-30c hsa-miR-125a-5p hsa-miR-571 hsa-miR-30d hsa-miR-3144-3p hsa-miR-374a* hsa-miR-144
		SwitchGear 3'UTR luciferase reporter plasmid: CYP24A1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CYP24A1 (see all 7) OriGene shRNA RFP: CYP24A1 OriGene siRNA: CYP24A1
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		GenScript: all cDNA clones in your preferred vector (see all 2): CYP24A1 (NM_000782)
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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYP24A1

Pathways & Interactions
for CYP24A1 gene

	Super-pathway	contained gene-specific pathways
1	Vitamin D2 (ergocalciferol) metabolism	Vitamin D2 (ergocalciferol) metabolism 1.00 Vitamin D synthesis 0.40 Vitamin D2 (ergocalciferol) metabolism 1.00 Vitamins 0.33
2	Cytochrome P450 - arranged by substrate type	Cytochrome P450 - arranged by substrate type 1.00 cytochrome P450 0.73 Phase 1 - Functionalization of compounds 0.74
3	Vitamin D (calciferol) metabolism	Vitamin D (calciferol) metabolism 1.00 Metabolism of steroid hormones and vitamin D 0.27 Steroid hormones 0.27
4	Transcription_Role of VDR in regulation of genes involved in osteoporosis	Transcription_Role of VDR in regulation of genes involved in osteoporosis 1.00 Transcription Role of VDR in regulation of genes involved in osteoporosis 0.80
5	Metabolism	Metabolism 1.00 Metabolism of lipids and lipoproteins 0.34

2 EMD Millipore Pathways for CYP24A1

	Transcription Role of VDR in regulation of genes involved in osteoporosis
	Vitamin D2 (ergocalciferol) metabolism

2 GeneGo (Thomson Reuters) Pathways for CYP24A1

	Transcription Role of VDR in regulation of genes involved in osteoporosis
	Vitamin D2 (ergocalciferol) metabolism

4 BioSystems Pathways for CYP24A1

	Vitamin D synthesis
	cytochrome P450
	Nuclear receptors in lipid metabolism and toxicity
	metapathway biotransformation

5/9        Reactome Pathways for CYP24A1

	Cytochrome P450 - arranged by substrate type
	Metabolism
	Steroid hormones
	Vitamin D (calciferol) metabolism
	Metabolism of steroid hormones and vitamin D

Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

Drugs & Compounds
for CYP24A1 gene

Transcripts
for CYP24A1 gene

Expression
for CYP24A1 gene

CYP24A1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CAATACTTAT

About this image
See CYP24A1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CYP24A1

SOURCE GeneReport for Unigene cluster: Hs.89663
    SABiosciences Expression via Pathway-Focused PCR Array including CYP24A1: 

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CYP24A1 Browse OriGene validated miRNA SYBR primer pairs
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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYP24A1

Orthologs
for CYP24A1 gene

Paralogs
for CYP24A1 gene

Paralogs for CYP24A1 gene

CYP11A1²  CYP27A1²  CYP11B1²  CYP11B2²  CYP27C1²  CYP27B1²  

7 SIMAP similar genes for CYP24A1 using alignment to 1 protein entry:     CP24A_HUMAN:

CYP24    CYP27C1    CYP27A1    CYP11B2    CYP11B1    CYP27B1

CYP11A1

CYP24A1 for paralogs           About GeneDecksing

Genomic Variants
for CYP24A1 gene

10/563 NCBI SNPs in CYP24A1 are shown (see all 563)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 20 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs790108781,2	F	--	49516161(+)	TGAAAT/CGGTTC	2	--	ds5001		1		WA	118
rs739126291,2	C	--	49516232(+)	AGAACA/GGGCTC	2	--	ds5001		2		WA	120
rs9276491,2	C,F,A	--	49516280(+)	TGTGTG/AACTGA	2	--	ds5001		1		NA	120
rs60139041,2	F	--	49516302(+)	GAAAGG/TGGGTA	2	--	ds5001		1		WA	118
rs2017832701,2	C	--	49516610(+)	CAAGAC/TGTGAA	2	--	ut31		0	--	--	--	--
rs1118019351,2	C	--	49516611(+)	AAGACA/GTGAAT	2	--	ut31		0	--	--	--	--
rs119073501,2	C,F,H	--	49516995(+)	GGCATG/AGGAAA	2	--	ut31 ese3		25		NA NS EA WA CSA	2464
rs752137381,2	C,F	--	49517151(+)	ATACAC/TGGACA	2	--	ut31		1		WA	118
rs169990601,2	C,F,H	--	49517429(+)	GGGAGG/ACCTGA	2	--	ut31 ese3		11		NA NS EA WA	1348
rs558151221,2	C	--	49517649(-)	GGTTAA/C/GAAACC	4	--	ut31		1		CSA	1

HapMap Linkage Disequilibrium report for CYP24A1 (52769988 - 52790516 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for CYP24A1
     1 Indel: 73531
Human Gene Mutation Database (HGMD): CYP24A1

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CYP24A1

DNA2.0 Custom Variant and Variant Library Synthesis for CYP24A1

Disorders / Diseases
for CYP24A1 gene

20/48 diseases for CYP24A1

10/24 Novoseek disease relationships for CYP24A1 gene (see all 24)    About this table

Publications
for CYP24A1 gene

PubMed articles for CYP24A1 gene, integrated from 9 sources (see all 245) (see top 10): (articles sorted by number of sources associating them with CYP24A1)

Utopia: connect your pdf to the dynamic world of online information

1. Metabolism of vitamin D3 by cytochromes P450. (PubMed id 15574355)^{2, 7, 9} Sakaki T.... Inouye K. (2005)
2. Evidence for the activation of 1alpha-hydroxyvitamin D2 by 25-hydroxyvitamin D-24-hydroxylase: delineation of pathways involving 1alpha,24-dihydroxyvitamin D2 and 1alpha,25-dihydroxyvitamin D2. (PubMed id 16516540)^{1, 7, 9} Masuda S....Jones G. (2006)
3. Human 25-hydroxyvitamin D 24-hydroxylase cytochrome P450 subunit maps to a different chromosomal location than that of pseudovitamin D- deficient rickets. (PubMed id 8266831)^{1, 2, 9} Labuda M.... Glorieux F.H. (1993)
4. Mutations in CYP24A1 and idiopathic infantile hypercalcemia. (PubMed id 21675912)^{1, 2} Schlingmann K.P.... Konrad M. (2011)
5. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)^{1, 2} Deloukas P....Rogers J. (2001)
6. Cloning of the human 1 alpha,25-dihydroxyvitamin D-3 24-hydroxylase gene promoter and identification of two vitamin D-responsive elements. (PubMed id 7632726)^{1, 2} Chen K.-S. and DeLuca H.F. (1995)
7. Isolation and expression of human 1,25-dihydroxyvitamin D3 24- hydroxylase cDNA. (PubMed id 8506296)^{1, 2} Chen K.-S.... Deluca H.F. (1993)
8. CYP24 splicing variants are associated with different patterns of constitutive and calcitriol-inducible CYP24 activity in human prostate cancer cell lines. (PubMed id 17368180)^{1, 9} Muindi J.R....Trump D.L. (2007)
9. Structure-function analysis of vitamin D 24-hydroxylase (CYP24A1) by site-directed mutagenesis: amino acid residues responsible for species-based difference of CYP24A1 between humans and rats. (PubMed id 16617161)^{1, 9} Hamamoto H....Sakaki T. (2006)
10. CYP24 promoter activity is affected by mechanical stress and mitogen-activated protein kinase in MG63 osteoblast-like cells. (PubMed id 18467787)^{1, 9} Toyoshita Y....Yokoyama A. (2008)
11. Steroid and xenobiotic receptor and vitamin D receptor crosstalk mediates CYP24 expression and drug-induced osteomalacia. (PubMed id 16691293)^{1, 9} Zhou C....Thummel K.E. (2006)
12. CYP24, the enzyme that catabolizes the antiproliferative agent vitamin D, is increased in lung cancer. (PubMed id 16708384)^{1, 9} Parise R.A....Hershberger P.A. (2006)
13. Clinical significance of the overexpression of the candidate oncogene CYP24 in esophageal cancer. (PubMed id 14760115)^{1, 9} Mimori K....Mori M. (2004)
14. Enzymatic studies on the key enzymes of vitamin D metabolism; 1 alpha-hydroxylase (CYP27B1) and 24-hydroxylase (CYP24). (PubMed id 11686044)^{7, 9} Inouye K. and Sakaki T. (2001)
15. Alternative splicing of vitamin D-24-hydroxylase: a novel mechanism for the regulation of extrarenal 1,25-dihydroxyvitamin D synthesis. (PubMed id 15788398)^{1, 9} Ren S.... Hewison M. (2005)
16. Possible involvement of pregnane X receptor-enhanced CYP24 expression in drug-induced osteomalacia. (PubMed id 15630458)^{1, 9} Pascussi J.M....Vilarem M.J. (2005)
17. Vitamin D-24-hydroxylase in benign and malignant brea st tissue and cell lines. (PubMed id 19667160)^{1, 9} Fischer D....Thill M. (2009)
18. Constitutive androstane receptor-vitamin D receptor crosstalk: consequence on CYP24 gene expression. (PubMed id 17585873)^{1, 9} Moreau A....Pascussi J.M. (2007)
19. Placenta-specific Methylation of the Vitamin D 24-Hydroxylase Gene: IMPLICATIONS FOR FEEDBACK AUTOREGULATION OF ACTIVE VITAMIN D LEVELS AT THE FETOMATERNAL INTERFACE. (PubMed id 19237542)^{1, 9} Novakovic B....Saffery R. (2009)
20. Single A326G mutation converts human CYP24A1 from 25-OH-D3-24-hydroxylase into -23-hydroxylase, generating 1alpha,25-(OH)2D3-26,23-lactone. (PubMed id 17646648)^{1, 9} Prosser D.E....Jones G. (2007)
21. [Recent studies on vitamin D metabolizing enzymes] (PubMed id 16816472)^{7, 9} Sakaki T. (2006)
22. HIV-1 protease inhibitor ritonavir potentiates the effect of 1,25-dihydroxyvitamin D3 to induce growth arrest and differentiation of human myeloid leukemia cells via down-regulation of CYP24. (PubMed id 16457885)^{1, 9} Ikezoe T....Taguchi H. (2006)
23. Transcriptional inhibition of CYP24 by genistein. (PubMed id 12485911)^{1, 9} Farhan H. and Cross H.S. (2002)
24. The candidate oncogene CYP24A1: A potential biomarker for colorectal tumorigenesis. (PubMed id 19901270)^{1, 9} HorvA!th H.C....KA!llay E. (2010)
25. Effects of MAPK signaling on 1,25-dihydroxyvitamin D-mediated CYP24 gene expression in the enterocyte-like cell line, Caco-2. (PubMed id 19097033)^{1, 9} Cui M....Fleet J.C. (2009)
26. CYP2R1-, CYP27B1- and CYP24-mRNA expression in German type 1 diabetes patients. (PubMed id 17223345)^{1, 9} Ramos-Lopez E....Badenhoop K. (2007)
27. RNAi-mediated silencing of CYP27B1 abolishes 1,25(OH)2D3 synthesis and reduces osteocalcin and CYP24 mRNA expression in human osteosarcoma (HOS) cells. (PubMed id 17254772)^{1, 9} Anderson P.H....Morris H.A. (2007)
28. Regulation of Vitamin D hydroxylases gene expression by 1,25-dihydroxyvitamin D3 and cyclic AMP in cultured human syncytiotrophoblasts. (PubMed id 17079137)^{1, 9} Avila E....Larrea F. (2007)
29. Association of the vitamin D metabolism gene CYP27B1 with type 1 diabetes. (PubMed id 17606874)^{1, 9} Bailey R....Todd J.A. (2007)
30. Hepatic activation and inactivation of clinically-relevant vitamin D analogs and prodrugs. (PubMed id 16886668)^{7, 9} Jones G....Mehta R. (2006)
31. Asthma families show transmission disequilibrium of gene variants in the vitamin D metabolism and signalling pathway. (PubMed id 16600026)^{1, 9} Wjst M....Andre E. (2006)
32. Spatio-temporal activation of chromatin on the human CYP24 gene promoter in the presence of 1alpha,25-Dihydroxyvitamin D3. (PubMed id 15919092)^{1, 9} Vaisanen S....Carlberg C. (2005)
33. The rapid effects of 1,25-dihydroxyvitamin D3 require the vitamin D receptor and influence 24-hydroxylase activity: studies in human skin fibroblasts bearing vitamin D receptor mutations. (PubMed id 14665637)^{1, 9} Nguyen T.M....Garabedian M. (2004)
34. Localization of the human vitamin D 24-hydroxylase gene (CYP24) to chromosome 20q13.2-->q13.3. (PubMed id 8440135)^{1, 9} Hahn C.N....Sutherland G.R. (1993)
35. A role for the phosphatidylinositol 3-kinase--protein kinase C zeta--Sp1 pathway in the 1,25-dihydroxyvitamin D3 induction of the 25 -hydroxyvitamin D3 24-hydroxylase gene in human kidney cells. (PubMed id 19922790)^{1, 9} Dwivedi P.P....Hii C.S. (2010)
36. CYP27A1 and CYP24 expression as a function of malignant transformation in the colon. (PubMed id 17875655)^{1, 9} Matusiak D. and Benya R.V. (2007)
37. Vitamin D pathway gene variants and prostate cancer r isk. (PubMed id 19454612)^{1, 9} Holt S.K....Stanford J.L. (2009)
38. Vitamin D-related genes, serum vitamin D concentrations and prostate cancer risk. (PubMed id 19255064)^{1, 9} Ahn J....Hayes R.B. (2009)
39. Vitamin D pathway gene polymorphisms, diet, and risk of postmenopausal breast cancer: a nested case-control study. (PubMed id 17244366)^{1, 9} McCullough M.L....Calle E.E. (2007)
40. Role of distal upstream sequence in vitamin D-induced expression of human CYP24 gene. (PubMed id 17475215)^{1, 9} Tashiro K....Ryoji M. (2007)
41. Cycling and early pregnant endometrium as a site of regulated expression of the vitamin D system. (PubMed id 16720713)^{1, 9} Vigano P....Di Blasio A.M. (2006)
42. Evidence for auto/paracrine actions of vitamin D in bone: 1alpha-hydroxylase expression and activity in human bone cells. (PubMed id 17023519)^{1, 9} van Driel M....van Leeuwen J.P. (2006)
43. Calcitriol regulates the expression of the genes encoding the three key vitamin D3 hydroxylases and the drug-metabolizing enzyme CYP3A4 in the human fetal intestine. (PubMed id 12641633)^{1, 9} Theodoropoulos C....Gascon-Barre M. (2003)
44. Maternal vitamin D predominates over genetic factors i n determining neonatal circulating vitamin D concentrations. (PubMed id 22648713)¹ Novakovic B....Saffery R. (2012)
45. Phorbol esters enhance 1a,25-dihydroxyvitamin D3-regul ated 25-hydroxyvitamin D-24-hydroxylase (CYP24A1) gene expression through ERK-me diated phosphorylation of specific protein 3 (Sp3) in Caco-2 cells. (PubMed id 22871965)¹ Jiang Y. and Fleet J.C. (2012)
46. Impaired vitamin D activation and association with CYP 24A1 haplotypes in differentiated thyroid carcinoma. (PubMed id 22690899)¹ Penna-Martinez M....Badenhoop K. (2012)
47. Polymorphisms related to the serum 25-hydroxyvitamin D level and risk of myocardial infarction, diabetes, cancer and mortality. The Tr omso Study. (PubMed id 22649517)¹ Jorde R....Grimnes G. (2012)
48. A local effect of CYP24 inhibition on lung tumor xenog raft exposure to 1,25-dihydroxyvitamin D(3) is revealed using a novel LC-MS/MS a ssay. (PubMed id 22285938)¹ Beumer J.H....Hershberger P.A. (2012)
49. Altered expression of key players in vitamin D metabol ism and signaling in malignant and benign thyroid tumors. (PubMed id 22511602)¹ Clinckspoor I....Decallonne B. (2012)
50. Expression of prostaglandin- and vitamin D-metabolisin g enzymes in benign and malignant breast cells. (PubMed id 22213328)¹ Thill M....Cordes T. (2012)
51. Genetic risk and a primary role for cell-mediated immu ne mechanisms in multiple sclerosis. (PubMed id 21833088)¹  ....Compston A. (2011)
52. Vitamin D metabolic pathway genes and risk of multiple sclerosis in Canadians. (PubMed id 21440908)¹ Orton S.M....Ebers G.C. (2011)
53. Inherited variation in vitamin D genes is associated with predisposition to autoimmune disease type 1 diabetes. (PubMed id 21441443)¹ Cooper J.D....Todd J.A. (2011)
54. Bioengineering anabolic vitamin D-25-hydroxylase acti vity into the human vitamin D catabolic enzyme, cytochrome P450 CYP24A1, by a V 391L mutation. (PubMed id 21697097)¹ Kaufmann M....Jones G. (2011)
55. CYP24A1 is an independent prognostic marker of surviv al in patients with lung adenocarcinoma. (PubMed id 21169243)¹ Chen G....Ramnath N. (2011)
56. Differential vitamin D 24-hydroxylase/CYP24A1 gene pr omoter methylation in endothelium from benign and malignant human prostate. (PubMed id 21725204)¹ Deeb K.K....Trump D.L. (2011)
57. Cytochromes P450 are essential players in the vitamin D signaling system. (PubMed id 20619365)⁷ Schuster I. (2011)
58. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (2011)
59. Marked increase in CYP24A1 gene expression in human p apillary thyroid cancer. (PubMed id 21385079)¹ Balla B....Lakatos P. (2011)
60. Common genetic variants in the vitamin D pathway incl uding genome-wide associated variants are not associated with breast cancer ris k among Chinese women. (PubMed id 21828234)¹ Dorjgochoo T....Shu X.O. (2011)
61. Systematic characterisation of the rat and human CYP2 4A1 promoter. (PubMed id 20450955)¹ Kumar R....Callen D.F. (2010)
62. CYP24A1 splice variants--implications for the antitum origenic actions of 1,25-(OH)2D3 in colorectal cancer. (PubMed id 20398751)¹ HorvA!th H.C....Kallay E. (2010)
63. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PubMed id 20453000)¹ Liu C.Y....Christiani D.C. (2010)
64. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)¹ Hendrickson S.L....O'Brien S.J. (2010)
65. Association of the vitamin D metabolism gene CYP24A1 with coronary artery calcification. (PubMed id 20847308)¹ Shen H....Mitchell B.D. (2010)
66. High-density polymorphisms analysis of 23 candidate g enes for association with bone mineral density. (PubMed id 20654748)¹ Giroux S....Rousseau F. (2010)
67. Genetic susceptibility to distinct bladder cancer sub phenotypes. (PubMed id 19692168)¹ Guey L.T....Malats N. (2010)
68. Infantile hypercalcemia and hypercalciuria: new insig hts into a vitamin D-dependent mechanism and response to ketoconazole treatment . (PubMed id 20394945)¹ Nguyen M....Garabedian M. (2010)
69. Vitamin D pathway gene variants and prostate cancer p rognosis. (PubMed id 20687218)¹ Holt S.K....Stanford J.L. (2010)
70. CYP24A1 inhibition enhances the antitumor activity of calcitriol. (PubMed id 20591973)¹ Muindi J.R....Johnson C.S. (2010)
71. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)¹ Bailey S.D....Anand S. (2010)
72. Common genetic determinants of vitamin D insufficienc y: a genome-wide association study. (PubMed id 20541252)¹ Wang T.J....Spector T.D. (2010)
73. Epigenetic regulation of vitamin D converting enzymes . (PubMed id 20304056)¹ Wjst M....Pukelsheim K. (2010)
74. Polymorphisms in vitamin D metabolism related genes a nd risk of multiple sclerosis. (PubMed id 20007432)¹ Simon K.C....Ascherio A. (2010)
75. Epigenetic silencing of CYP24 in the tumor microenvir onment. (PubMed id 20304059)¹ Johnson C.S....Trump D.L. (2010)
76. Alterations in Vitamin D signalling and metabolic pat hways in breast cancer progression: a study of VDR, CYP27B1 and CYP24A1 express ion in benign and malignant breast lesions. (PubMed id 20831823)¹ Lopes N....Schmitt F. (2010)
77. Transcriptional and physiological responses to chronic ACTH treatment by the mouse kidney. (PubMed id 19920212)⁷ Dunbar D.R....Bailey M.A. (2010)
78. Epigenetic regulation of vitamin D 24-hydroxylase/CYP 24A1 in human prostate cancer. (PubMed id 20587525)¹ Luo W....Trump D.L. (2010)
79. Expression of vitamin D receptor (VDR), cyclooxygenas e-2 (COX-2) and 15-hydroxyprostaglandin dehydrogenase (15-PGDH) in benign and m alignant ovarian tissue and 25-hydroxycholecalciferol (25(OH2)D3) and prostagla ndin E2 (PGE2) serum level in ovarian cancer patients. (PubMed id 20304053)¹ Thill M....Becker S. (2010)
80. The number of vitamin D receptor binding sites define s the different vitamin D responsiveness of the CYP24 gene in malignant and nor mal mammary cells. (PubMed id 20460683)¹ Matilainen J.M....VAoisAonen S. (2010)
81. SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. (PubMed id 19934256)⁷ Preissner S....Preissner R. (2010)
82. Comprehensive association analysis of nine candidate genes with serum 25-hydroxy vitamin D levels among healthy Caucasian subjects. (PubMed id 20809279)¹ Bu F.X....Zhao L.J. (2010)
83. PTEN identified as important risk factor of chronic o bstructive pulmonary disease. (PubMed id 19625176)¹ Hosgood H.D....Lan Q. (2009)
84. Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. (PubMed id 19170196)¹ Shen M....Lan Q. (2009)
85. Genetic variation in CYP27B1 is associated with conge stive heart failure in patients with hypertension. (PubMed id 19891555)¹ Wilke R.A....McCarty C.A. (2009)
86. Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PubMed id 19343046)¹ Saito A....Kamatani N. (2009)
87. Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)¹ Talmud P.J.... . (2009)
88. Asthma and genes encoding components of the vitamin D pathway. (PubMed id 19852851)¹ BossAc Y....Laprise C. (2009)
89. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)¹ Yerges L.M....Zmuda J.M. (2009)
90. Metabolism of 1alpha,25-dihydroxyvitamin D2 by human CYP24A1. (PubMed id 19393625)¹ Urushino N....Sakaki T. (2009)
91. Single and multigenic analysis of the association bet ween variants in 12 steroid hormone metabolism genes and risk of prostate cance r. (PubMed id 19505920)¹ Beuten J....Leach R.J. (2009)
92. Vitamin D related genes, CYP24A1 and CYP27B1, and col on cancer risk. (PubMed id 19706847)¹ Dong L.M....Peters U. (2009)
93. A novel SNP in a vitamin D response element of the CYP24A1 promoter reduces protein binding, transactivation, and gene expression. (PubMed id 18824104)¹ Roff A. and Wilson R.T. (2008)
94. Genetic variation in calcium-sensing receptor and risk for colon cancer. (PubMed id 18843020)¹ Dong L.M....Peters U. (2008)
95. Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway. (PubMed id 18676680)¹ Hosgood H.D....Lan Q. (2008)
96. Selective use of multiple vitamin D response elements underlies the 1 alpha,25-dihydroxyvitamin D3-mediated negative regulation of the human CYP27B1 gene. (PubMed id 17426122)¹ Turunen M.M....Vaisanen S. (2007)
97. Comprehensive association analysis of the vitamin D pathway genes, VDR, CYP27B1, and CYP24A1, in prostate cancer. (PubMed id 17932346)¹ Holick C.N....Peters U. (2007)
98. Vitamin D. (PubMed id 15951480)¹ Dusso A.S....Slatopolsky E. (2005)
99. Metabolism of 2 alpha-propoxy-1 alpha,25-dihydroxyvit amin D3 and 2 alpha-(3-hydroxypropoxy)-1 alpha,25-dihydroxyvitamin D3 by human CYP27A1 and CYP24A1. (PubMed id 15764712)⁷ Abe D....Inouye K. (2005)
100. Paricalcitol: a review of its use in the management o f secondary hyperparathyroidism. (PubMed id 15733015)⁷ Robinson D.M. and Scott L.J. (2005)
101. Metabolism of A-ring diastereomers of 1alpha,25-dihydroxyvitamin D3 by CYP24A1. (PubMed id 15358094)¹ Kusudo T....Inouye K. (2004)
102. Novel metabolism of 1 alpha,25-dihydroxyvitamin D3 with C24-C25 bond cleavage catalyzed by human CYP24A1. (PubMed id 15078099)¹ Sawada N....Inouye K. (2004)
103. Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants. (PubMed id 15128046)¹ Nelson D.R....Nebert D.W. (2004)
104. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)¹ Brandenberger R.... Stanton L.W. (2004)
105. Overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormones. (PubMed id 15583024)¹ Payne A.H. and Hales D.B. (2004)
106. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
107. Regulation of 25-hydroxyvitamin D3-1 alpha-hydroxylase and production of 1 alpha,25-dihydroxyvitamin D3 by human dendritic cells. (PubMed id 12855575)¹ Fritsche J....Kreutz M. (2003)
108. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
109. Newly established assay method for 25-hydroxyvitamin D3 24-hydroxylase revealed much lower Km for 25-hydroxyvitamin D3 than for 1alpha,25-dihydroxyvitamin D3. (PubMed id 11149490)¹ Taniguchi T....Setoguchi T. (2001)
110. Constitutive expression of 25-hydroxyvitamin D3-1alpha-hydroxylase in a transformed human proximal tubule cell line: evidence for direct regulation of vitamin D metabolism by calcium. (PubMed id 10218951)¹ Bland R....Hewison M. (1999)
111. Recent progress in enzymology and molecular biology of enzymes involved in vitamin D metabolism. (PubMed id 7595086)¹ Okuda K....Ohyama Y. (1995)
112. Expression of 25-hydroxyvitamin D3-24-hydroxylase mRNA in cultured human keratinocytes. (PubMed id 7938037)¹ Chen M.L....Holick M.F. (1994)
113. Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening. (PubMed id 7829101)¹ Robertson N.G....Morton C.C. (1994)
114. Human CYP24 catalyzing the inactivation of calcitriol is post-transcriptionally regulated by miR-125b. (PubMed id 19570947)⁹ Komagata S....Yokoi T. (2009)
115. Nuclear xenobiotic receptor pregnane X receptor locks corepressor silencing mediator for retinoid and thyroid hormone receptors (SMRT) onto the CYP24A1 promoter to attenuate vitamin D3 activation. (PubMed id 18981260)⁹ Konno Y....Negishi M. (2009)
116. C-25 hydroxylation of 1alpha,24(R)-dihydroxyvitamin D3 is catalyzed by 25-hydroxyvitamin D3-24-hydroxylase (CYP24A1): metabolism studies with human keratinocytes and rat recombinant CYP24A1. (PubMed id 15488475)⁹ Astecker N....Reddy G.S. (2004)
117. Induction of the vitamin D 24-hydroxylase (CYP24) by 1,25-dihydroxyvitamin D3 is regulated by parathyroid hormone in UMR106 osteoblastic cells. (PubMed id 9681485)⁹ Armbrecht H.J....Kumar V.B. (1998)
118. Metabolism of 26,26,26,27,27,27-F6-1alpha,25-dihydroxyvitamin D3 by CYP24: species-based difference between humans and rats. (PubMed id 12787875)⁹ Sakaki T....Inouye K. (2003)
119. Combination of vitamin D metabolites with selective inhibitors of vitamin D metabolism. (PubMed id 12899522)⁹ Schuster I....Vorisek G. (2003)
120. Selective inhibitors of CYP24: mechanistic tools to explore vitamin D metabolism in human keratinocytes. (PubMed id 11179754)⁹ Schuster I....Vorisek G. (2001)
121. Molecular action of 1,25-dihydroxyvitamin D3 and phorbol ester on the activation of the rat cytochrome P450C24 (CYP24) promoter: role of MAP kinase activities and identification of an important transcription factor binding site. (PubMed id 15836435)⁹ Nutchey B.K....Hii C.S. (2005)
122. Dual metabolic pathway of 25-hydroxyvitamin D3 catalyzed by human CYP24. (PubMed id 11012668)⁹ Sakaki T....Inouye K. (2000)
123. Quantification of mRNA for the vitamin D metabolizing enzymes CYP27B1 and CYP24 and vitamin D receptor in kidney using real-time reverse transcriptase- polymerase chain reaction. (PubMed id 12914530)⁹ Anderson P.H....Morris H.A. (2003)
124. The aryl hydrocarbon receptor activator benzo[a]pyrene enhances vitamin D3 catabolism in macrophages. (PubMed id 19244278)⁹ Matsunawa M....Makishima M. (2009)
125. Homology model of 1alpha,25-dihydroxyvitamin D3 24-hydroxylase cytochrome P450 24A1 (CYP24A1): active site architecture and ligand binding. (PubMed id 17240137)⁹ Gomaa M.S....Brancale A. (2007)
126. A 24-phenylsulfone analog of vitamin D inhibits 1alpha,25-dihydroxyvitamin D(3) degradation in vitamin D metabolism-competent cells. (PubMed id 17182978)⁹ Lechner D....Cross H.S. (2007)
127. Generation of a homology model for the human cytochrome P450, CYP24A1, and the testing of putative substrate binding residues by site-directed mutagenesis and enzyme activity studies. (PubMed id 17224124)⁹ Masuda S....Jones G. (2007)
128. Expression of VDR and CYP24A1 mRNA in human tumors. (PubMed id 16180015)⁹ Anderson M.G....Wu-Wong J.R. (2006)
129. QW-1624F2-2, a synthetic analogue of 1,25-dihydroxyvitamin D3, enhances the response to other deltanoids and suppresses the invasiveness of human metastatic breast tumor cells. (PubMed id 17121927)⁹ Sundaram S....Gewirtz D.A. (2006)
130. 1,25-Dihydroxyvitamin D3 stimulates cyclic vitamin D receptor/retinoid X receptor DNA-binding, co-activator recruitment, and histone acetylation in intact osteoblasts. (PubMed id 15647825)⁹ Kim S....Pike J.W. (2005)
131. Determinants of circulating 1,25-dihydroxyvitamin D3 levels: the role of renal synthesis and catabolism of vitamin D. (PubMed id 15225756)⁹ Anderson P.H....Morris H.A. (2004)
132. Phytoestrogens and vitamin D metabolism: a new concept for the prevention and therapy of colorectal, prostate, and mammary carcinomas. (PubMed id 15113973)⁹ Cross H.S....Armbrecht H.J. (2004)
133. Role of 24-hydroxylase in vitamin D3 growth response of OVCAR-3 ovarian cancer cells. (PubMed id 14648702)⁹ Miettinen S....Ylikomi T. (2004)
134. Extensive methylation of CpG island of CYP24 gene in osteoblastic ROS17/2.8 cells. (PubMed id 12903199)⁹ Ohyama Y....Ide H. (2002)
135. Mouse vitamin D-24-hydroxylase: molecular cloning, tissue distribution, and transcriptional regulation by 1alpha,25-dihydroxyvitamin D3. (PubMed id 9165006)⁹ Akeno N....Horiuchi N. (1997)
136. Molecular cloning of 25-hydroxyvitamin D-3 24-hydroxylase (Cyp-24) from mouse kidney: its inducibility by vitamin D-3. (PubMed id 7578252)⁹ Itoh S....Mimura T. (1995)
137. Increase of renal 25-hydroxyvitamin D3-24-hydroxylase activity and its messenger ribonucleic acid level in 1 alpha-hydroxyvitamin D3-administered rats: possibility of the presence of two forms of 24-hydroxylase. (PubMed id 8410379)⁹ Akeno N....Horiuchi N. (1993)
138. Monocyte fructose 1,6-bisphosphatase and cytidine deaminase enzyme activities: potential pharmacodynamic measures of calcitriol effects in cancer patients. (PubMed id 16680461)⁹ Muindi J.R....Trump D.L. (2007)
139. Vitamin D-resistant rickets and type 1 diabetes in a child with compound heterozygous mutations of the vitamin D receptor (L263R and R391S): dissociated responses of the CYP-24 and rel-B promoters to 1,25-dihydroxyvitamin D3. (PubMed id 16753019)⁹ Nguyen M....Garabedian M. (2006)
140. Selective inhibition of vitamin D hydroxylases in human keratinocytes. (PubMed id 11179750)⁹ Schuster I....Vorisek G. (2001)
141. Metabolism of 26,27-hexafluoro-1 alpha,25-dihydroxyvitamin D3 and 26,27-hexafluoro-1 alpha,23(S)25-trihydroxyvitamin D3 in ROS17/2.8 cells transfected with a plasmid expressing CYP24. (PubMed id 11197067)⁹ Miyahara T....Nemoto N. (2000)
142. Expression and activity of vitamin D-metabolizing cytochrome P450s (CYP1alpha and CYP24) in human nonsmall cell lung carcinomas. (PubMed id 10385427)⁹ Jones G....Petkovich M. (1999)
143. Anti-proliferative effects of calcitriol on endothelial cells derived from two different microenvironments. (PubMed id 17368191)⁹ Chung I....Trump D.L. (2007)
144. Metabolism of vitamin D3 in human osteoblasts: evidence for autocrine and paracrine activities of 1 alpha,25-dihydroxyvitamin D3. (PubMed id 17395559)⁹ Atkins G.J....Morris H.A. (2007)
145. Gene-specific fluorescence in-situ hybridization analysis on tissue microarray to refine the region of chromosome 20q amplification in melanoma. (PubMed id 17235240)⁹ Koynova D.K....Gruis N.A. (2007)
146. In vitro comparison of the vitamin D endocrine system in 1,25(OH)2D3-responsive and -resistant melanoma cells. (PubMed id 17172823)⁹ Reichrath J....Seifert M. (2007)
147. Antineoplastic agents target the 25-hydroxyvitamin D3 24-hydroxylase messenger RNA for degradation: implications in anticancer activity. (PubMed id 18089708)⁹ Tan J....Hii C.S. (2007)
148. Substrate and enzyme trafficking as a means of regulating 1,25-dihydroxyvitamin D synthesis and action: the human innate immune response. (PubMed id 18290716)⁹ Adams J.S....Hewison M. (2007)
149. Dermal fibroblasts pretreated with a sterol Delta7-reductase inhibitor produce 25-hydroxyvitamin D3 upon UVB irradiation. (PubMed id 16824767)⁹ Vantieghem K....Segaert S. (2006)
150. Vitamin D(3) metabolism in human glioblastoma multiforme: functionality of CYP27B1 splice variants, metabolism of calcidiol, and effect of calcitriol. (PubMed id 16061850)⁹ Diesel B....Meese E. (2005)
151. Epigenetic regulation of vitamin D hydroxylase expression and activity in normal and malignant human prostate cells. (PubMed id 15860259)⁹ Khorchide M....Cross H.S. (2005)
152. Using chromatin immunoprecipitation to monitor 1alpha,25-dihydroxyvitamin D3-dependent chromatin activity on the human CYP24 promoter. (PubMed id 15225785)⁹ Vaisanen S....Carlberg C. (2004)
153. Differential biological effects of 1,25-dihydroxyVitamin D3 on melanoma cell lines in vitro. (PubMed id 15225804)⁹ Seifert M....Reichrath J. (2004)
154. Analysis of the vitamin D system in basal cell carcinomas (BCCs). (PubMed id 15077124)⁹ Mitschele T....Reichrath J. (2004)
155. Characterization of vitamin D-mediated induction of the CYP 24 transcription. (PubMed id 15489002)⁹ Tashiro K....Ryoji M. (2004)
156. Analysis of the vitamin D system in cervical carcinomas, breast cancer and ovarian cancer. (PubMed id 12899526)⁹ Friedrich M....Reichrath J. (2003)
157. Hormonal regulation of 25-hydroxyvitamin D3-1alpha-hydroxylase and 24-hydroxylase gene transcription in opossum kidney cells. (PubMed id 12504896)⁹ Armbrecht H.J....Boltz M.A. (2003)
158. Clonal differences in expression of 25-hydroxyvitamin D(3)-1alpha-hydroxylase, of 25-hydroxyvitamin D(3)-24-hydroxylase, and of the vitamin D receptor in human colon carcinoma cells: effects of epidermal growth factor and 1alpha,25-dihydroxyvitamin D(3). (PubMed id 12027461)⁹ Bareis P....Cross H.S. (2002)
159. 25-hydroxy-vitamin d metabolism in human colon cancer cells during tumor progression. (PubMed id 11467853)⁹ Bareis P....Peterlik M. (2001)
160. Prostaglandin E2 regulates vitamin D receptor expression, vitamin D-24-hydroxylase activity and cell proliferation in an adherent human myeloid leukemia cell line (Ad-HL60). (PubMed id 10410379)⁹ Smith S.J....Mawer E.B. (1999)
161. Autocrine control of vitamin D metabolism in synovial cells from arthritic patients. (PubMed id 10340962)⁹ Smith S.J....Mawer E.B. (1999)
162. Different mechanisms of hydroxylation site selection by liver and kidney cytochrome P450 species (CYP27 and CYP24) involved in vitamin D metabolism. (PubMed id 7622489)⁹ Dilworth F.J....Jones G. (1995)
163. 20,23-dihydroxyvitamin D3, novel P450scc product, sti mulates differentiation and inhibits proliferation and NF-kappaB activity in hu man keratinocytes. (PubMed id 20020487)⁹ Janjetovic Z....Slominski A.T. (2010)
164. Characterization of the vitamin D endocrine system in human sebocytes in vitro. (PubMed id 19027855)⁹ KrAomer C....Reichrath J. (2009)
165. Evaluation of 19-nor-2alpha-(3-hydroxypropyl)-1alpha, 25-dihydroxyvitamin D3 as a therapeutic agent for androgen-dependent prostate c ancer. (PubMed id 19667147)⁹ Flanagan J.N....Chen T.C. (2009)
166. Expression of 25-hydroxyvitamin D3-24-hydroxylase in benign and malignant ovarian cell lines and tissue. (PubMed id 19667159)⁹ Fischer D....Thill M. (2009)
167. 1alpha,25-dihydroxyvitamin D3 downregulates CYP27B1 and induces CYP24A1 in colon cells. (PubMed id 17029768)⁹ Lechner D....Cross H.S. (2007)
168. Metabolism of vitamin D3 in the placental tissue of n ormal and preeclampsia complicated pregnancies and premature births. (PubMed id 17629157)⁹ Fischer D....Friedrich M. (2007)
169. Co-chaperone potentiation of vitamin D receptor-mediated transactivation: a role for Bcl2-associated athanogene-1 as an intracellular-binding protein for 1,25-dihydroxyvitamin D3. (PubMed id 17693608)⁹ Chun R.F....Adams J.S. (2007)
170. Intestinal and hepatic CYP3A4 catalyze hydroxylation of 1alpha,25-dihydroxyvitamin D(3): implications for drug-induced osteomalacia. (PubMed id 16207822)⁹ Xu Y....Thummel K.E. (2006)
171. UVB-induced 1,25(OH)2D3 production and vitamin D activity in intestinal CaCo-2 cells and in THP-1 macrophages pretreated with a sterol Delta7-reductase inhibitor. (PubMed id 16598763)⁹ Vantieghem K....Segaert S. (2006)
172. Genistein and 17beta-estradiol, but not equol, regulate vitamin D synthesis in human colon and breast cancer cells. (PubMed id 16886669)⁹ Lechner D....Cross H.S. (2006)
173. Genistein potentiates the growth inhibitory effects of 1,25-dihydroxyvitamin D3 in DU145 human prostate cancer cells: role of the direct inhibition of CYP24 enzyme activity. (PubMed id 15955619)⁹ Swami S....Feldman D. (2005)
174. The Vitamin D endocrine system of the gut--its possible role in colorectal cancer prevention. (PubMed id 16081282)⁹ Cross H.S....Kallay E. (2005)
175. Analysis of the vitamin D system in cutaneous squamous cell carcinomas. (PubMed id 14984574)⁹ Reichrath J....Holick M.F. (2004)
176. Synthesis and CYP24 inhibitory activity of 2-substituted-3,4-dihydro-2H-naphthalen-1-one (tetralone) derivatives. (PubMed id 15482941)⁹ Yee S.W. and Simons C. (2004)
177. Isoflavonoids inhibit catabolism of vitamin D in prostate cancer cells. (PubMed id 12270218)⁹ Farhan H....Cross H.S. (2002)
178. Repression of basal transcription by vitamin D receptor: evidence for interaction of unliganded vitamin D receptor with two receptor interaction domains in RIP13delta1. (PubMed id 9687155)⁹ Dwivedi P.P....May B.K. (1998)
179. Modulation of the bovine innate immune response by pr oduction of 1alpha,25-dihydroxyvitamin D(3) in bovine monocytes. (PubMed id 20172224)⁹ Nelson C.D....Lippolis J.D. (2010)
180. Snail2 cooperates with Snail1 in the repression of vi tamin D receptor in colon cancer. (PubMed id 19502595)⁹ Larriba M.J....MuA+oz A. (2009)
181. Human duodenum responses to vitamin D metabolites of TRPV6 and other genes involved in calcium absorption. (PubMed id 19779013)⁹ Balesaria S....Walters J.R. (2009)
182. How to optimize vitamin D supplementation to prevent cancer, based on cellular adaptation and hydroxylase enzymology. (PubMed id 19667164)⁹ Vieth R. (2009)
183. Reverse transcriptase inhibitors induce cell differentiation and enhance the immunogenic phenotype in human renal clear-cell carcinoma. (PubMed id 18351578)⁹ Landriscina M....Ranieri E. (2008)
184. Nutritional calcium modulates colonic expression of vitamin D receptor and pregnane X receptor target genes. (PubMed id 18327873)⁹ Nittke T....Cross H.S. (2008)
185. 1,25-dihydroxyvitamin D(3) promotes IL-10 production in human B cells. (PubMed id 18651709)⁹ Heine G....Worm M. (2008)
186. 20-Hydroxyvitamin D3, a product of vitamin D3 hydroxylation by cytochrome P450scc, stimulates keratinocyte differentiation. (PubMed id 18368131)⁹ Zbytek B....Slominski A.T. (2008)
187. Lithocholic acid derivatives act as selective vitamin D receptor modulators without inducing hypercalcemia. (PubMed id 18180267)⁹ Ishizawa M....Makishima M. (2008)
188. Kinetic studies of 25-hydroxy-19-nor-vitamin D3 and 1 alpha,25-dihydroxy-19-nor-vitamin D3 hydroxylation by CYP27B1 and CYP24A1. (PubMed id 17553915)⁹ Urushino N....Sakaki T. (2007)
189. Wavelength-dependent induction of CYP24A1-mRNA after UVB-triggered calcitriol synthesis in cultured human keratinocytes. (PubMed id 16902422)⁹ Bar M....Meurer M. (2007)
190. Relative expression of 1,25-dihydroxyvitamin D3 receptor, vitamin D 1 alpha-hydroxylase, vitamin D 24-hydroxylase, and vitamin D 25-hydroxylase in endometriosis and gynecologic cancers. (PubMed id 17913968)⁹ Agic A....Hornung D. (2007)
191. Vitamin D3-24-hydroxylase (CYP24) as a potential target for intervention with diabetic and nondiabetic nephropathy. (PubMed id 17323831)⁹ Weiher H. and Zwacka R.M. (2007)
192. Overexpression of ER and VDR is not sufficient to make ER-negative MDA-MB231 breast cancer cells responsive to 1alpha-hydroxyvitamin D5. (PubMed id 17130524)⁹ Peng X....Mehta R.G. (2007)
193. Nucleo-cytoplasmic cycling of the vitamin D receptor in the enterocyte-like cell line, Caco-2. (PubMed id 16960876)⁹ Klopot A....Fleet J.C. (2007)
194. Early lethality in Hyp mice with targeted deletion of Pth gene. (PubMed id 17615144)⁹ Bai X....Karaplis A.C. (2007)
195. [The influence of isoflavonoids on the antitumor activity of vitamin D3] (PubMed id 17507873)⁹ Wietrzyk J. (2007)
196. Cytogenetic characterization and gene expression profiling of the trastuzumab-resistant breast cancer cell line JIMT-1. (PubMed id 17213017)⁹ Rennstam K....Isola J. (2007)
197. Calcitriol and genistein actions to inhibit the prostaglandin pathway: potential combination therapy to treat prostate cancer. (PubMed id 17182827)⁹ Swami S....Feldman D. (2007)
198. Array CGH identifies distinct DNA copy number profiles of oncogenes and tumor suppressor genes in chromosomal- and microsatellite-unstable sporadic colorectal carcinomas. (PubMed id 17143621)⁹ Lassmann S....Werner M. (2007)
199. Resistance to 1,25D-induced differentiation in human acute myeloid leukemia HL60-40AF cells is associated with reduced transcriptional activity and nuclear localization of the vitamin D receptor. (PubMed id 17520689)⁹ Garay E....Studzinski G.P. (2007)
200. Vitamin D--metabolism in the human breast cancer cell line MCF-7. (PubMed id 16886688)⁹ Diesing D....Friedrich M. (2006)
201. Megalin-mediated endocytosis of vitamin D binding protein correlates with 25-hydroxycholecalciferol actions in human mammary cells. (PubMed id 17056796)⁹ Rowling M.J....Welsh J. (2006)
202. Monocyte-derived cells express CYP27A1 and convert vitamin D3 into its active metabolite. (PubMed id 16930540)⁹ Gottfried E....Kreutz M. (2006)
203. Androgen enhances the antiproliferative activity of v itamin D3 by suppressing 24-hydroxylase expression in LNCaP cells. (PubMed id 16524720)⁹ Lou Y.R. and Tuohimaa P. (2006)
204. Effects of vitamin D analogs on the expression of plasminogen activator inhibitor-1 in human vascular cells. (PubMed id 16371233)⁹ Wu-Wong J.R....Ma J. (2006)
205. Human mammary epithelial cells express CYP27B1 and are growth inhibited by 25-hydroxyvitamin D-3, the major circulating form of vitamin D-3. (PubMed id 16549446)⁹ Kemmis C.M....Welsh J. (2006)
206. Vitamin D compounds: clinical development as cancer therapy and prevention agents. (PubMed id 16886663)⁹ Trump D.L....Johnson C.S. (2006)
207. Prohibitin is a novel target gene of vitamin D involved in its antiproliferative action in breast cancer cells. (PubMed id 16849588)⁹ Peng X....Mehta R.G. (2006)
208. Gene regulatory potential of nonsteroidal vitamin D receptor ligands. (PubMed id 15860548)⁹ Perakyla M....Carlberg C. (2005)
209. 5alpha-dihydrotestosterone inhibits 1alpha,25-dihydroxyvitamin D3-induced expression of CYP24 in human prostate cancer cells. (PubMed id 15538745)⁹ Lou Y.R....Tuohimaa P. (2005)
210. Regulation of the human cyclin C gene via multiple vitamin D3-responsive regions in its promoter. (PubMed id 15863722)⁹ Sinkkonen L....Carlberg C. (2005)
211. The human peroxisome proliferator-activated receptor delta gene is a primary target of 1alpha,25-dihydroxyvitamin D3 and its nuclear receptor. (PubMed id 15890193)⁹ Dunlop T.W....Carlberg C. (2005)
212. Cell specificity and properties of the C-3 epimerization of Vitamin D3 metabolites. (PubMed id 15225744)⁹ Kamao M....Okano T. (2004)
213. Mechanisms of decreased Vitamin D 1alpha-hydroxylase activity in prostate cancer cells. (PubMed id 15223133)⁹ Ma J.F....Peehl D.M. (2004)
214. The highly conserved region of the co-repressor Sin3A functionally interacts with the co-repressor Alien. (PubMed id 15173382)⁹ Moehren U....Baniahmad A. (2004)
215. Regulation of 25-hydroxyvitamin D3 1alpha-hydroxylase, 1,25-dihydroxyvitamin D3 24-hydroxylase and vitamin D receptor gene expression by 8-bromo cyclic AMP in cultured human syncytiotrophoblast cells. (PubMed id 15225757)⁹ Avila E....Larrea F. (2004)
216. Enzymes involved in the activation and inactivation of vitamin D. (PubMed id 15544953)⁹ Prosser D.E. and Jones G. (2004)
217. No evidence for amplification of 25-hydroxyvitamin D-1alpha-OHase (1alpha-OHase) or 1,25-dihydroxyvitamin D-24-OHase (24-OHase) genes in malignant melanoma (MM). (PubMed id 15225766)⁹ Reichrath J....Seifert M. (2004)
218. Eight cytochrome P450s catalyze vitamin D metabolism. (PubMed id 15353333)⁹ Ohyama Y. and Yamasaki T. (2004)
219. Selective regulation of vitamin D receptor-responsive genes by TFIIH. (PubMed id 15494306)⁹ Drane P.... Egly J.-M. (2004)
220. 2-Methylene-19-nor-(20S)-1,25-dihydroxyvitamin D3 potently stimulates gene-specific DNA binding of the vitamin D receptor in osteoblasts. (PubMed id 12796488)⁹ Yamamoto H....Pike J.W. (2003)
221. Analysis of the vitamin D system in cutaneous malignancies. (PubMed id 12899528)⁹ Kamradt J....Reichrath J. (2003)
222. Vitamin D analogs--drug design based on proteins involved in vitamin D signal transduction. (PubMed id 12570725)⁹ Masuda S. and Jones G. (2003)
223. Genistein inhibits vitamin D hydroxylases CYP24 and CYP27B1 expression in prostate cells. (PubMed id 12732287)⁹ Farhan H....Cross H.S. (2003)
224. Regulation of extrarenal synthesis of 1,25-dihydroxyvitamin D3--relevance for colonic cancer prevention and therapy. (PubMed id 14585316)⁹ Cross H.S....Lechner D. (2003)
225. Phytoestrogens and 17beta-estradiol influence vitamin D metabolism and receptor expression-relevance for colon cancer prevention. (PubMed id 12899537)⁹ Lechner D. and Cross H.S. (2003)
226. Regulation of extrarenal vitamin D metabolism as a tool for colon and prostate cancer prevention. (PubMed id 12899539)⁹ Cross H.S....Manhardt T. (2003)
227. Regulation of 1,25-dihydroxyvitamin d synthesis by intracellular vitamin d binding protein-1. (PubMed id 12239126)⁹ Wu S....Adams J.S. (2002)
228. Vitamin D-inducible calcium transport and gene expression in three Caco-2 cell lines. (PubMed id 12181175)⁹ Fleet J.C....Wood R.J. (2002)
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230. Antiproliferative effects of 1,25-dihydroxyvitamin D3 on breast cells: a mini review. (PubMed id 11743608)⁹ Bortman P....Brentani M.M. (2002)
231. A quantitative trait locus influencing estrogen levels maps to a region homologous to human chromosome 20. (PubMed id 11242591)⁹ Martin L.J....Comuzzie A.G. (2001)
232. Natural metabolites of 1alpha,25-dihydroxyvitamin D(3) retain biologic activity mediated through the vitamin D receptor. (PubMed id 10797570)⁹ Harant H....Lindley I.J. (2000)
233. Quantitative mapping of amplicon structure by array C GH identifies CYP24 as a candidate oncogene. (PubMed id 10835626)⁹ Albertson D.G....Pinkel D. (2000)
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235. Intracellular vitamin D binding proteins: novel facilitators of vitamin D-directed transactivation. (PubMed id 10976917)⁹ Wu S....Adams J.S. (2000)
236. Ultraviolet irradiation of human skin causes functional vitamin A deficiency, preventable by all-trans retinoic acid pre-treatment. (PubMed id 10202931)⁹ Wang Z....Fisher G.J. (1999)
237. Cloning of porcine 25-hydroxyvitamin D3 1alpha-hydroxylase and its regulation by cAMP in LLC-PK1 cells. (PubMed id 10232681)⁹ Yoshida T....Saruta T. (1999)
238. Mechanistic studies to evaluate the enhanced antiprol iferation of human keratinocytes by 1alpha,25-dihydroxyvitamin D(3)-3-bromoacet ate, a covalent modifier of vitamin D receptor, compared to 1alpha,25-dihydroxy vitamin D(3). (PubMed id 10496974)⁹ Chen M.L....Ray R. (1999)
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242. The genes for endothelin 3, vitamin D 24-hydroxylase, and melanocortin 3 receptor map to distal mouse chromosome 2, in the region of conserved synteny with human chromosome 20. (PubMed id 8000144)⁹ Malas S....Abbott C. (1994)

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