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CYP20A1 Gene

protein-coding   GIFtS: 57
GCID: GC02P204103

Cytochrome P450, Family 20, Subfamily A, Polypeptide 1

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cytochrome P450, Family 20, Subfamily A, Polypeptide 11 2
CYP-M2
Cytochrome P450 20A12
Cytochrome P450 Monooxygenase2
EC 1.14.-.-3

External Ids:    HGNC: 205761   Entrez Gene: 574042   Ensembl: ENSG000001190047   UniProtKB: Q6UW023   

Export aliases for CYP20A1 gene to outside databases

Previous GC identifers: GC02P202828 GC02P204067 GC02P204305 GC02P203928 GC02P203811 GC02P195951


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CYP20A1 Gene:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are
monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids
and other lipids. This protein lacks one amino acid of the conserved heme binding site. It also lacks the
conserved I-helix motif AGX(D,E)T, suggesting that its substrate may carry its own oxygen. (provided by RefSeq,
Jul 2008)

GeneCards Summary for CYP20A1 Gene:
CYP20A1 (cytochrome P450, family 20, subfamily A, polypeptide 1) is a protein-coding gene. Diseases associated with CYP20A1 include fungal meningitis, and scabies. GO annotations related to this gene include electron carrier activity and heme binding.

Gene Wiki entry for CYP20A1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CYP20A1 gene promoter:
         Bach1   NF-1   AML1a   POU3F1   HNF-1A   Evi-1   Nkx6-1   POU2F1   POU2F1a   HNF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCYP20A1 promoter sequence
   Search Chromatin IP Primers for CYP20A1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CYP20A1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q33.2   Ensembl cytogenetic band:  2q33.2   HGNC cytogenetic band: 2q33

CYP20A1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CYP20A1 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P204103:  view genomic region     (about GC identifiers)

Start:
204,103,164 bp from pter      End:
204,170,563 bp from pter
Size:
67,400 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CP20A_HUMAN, Q6UW02 (See protein sequence)
Recommended Name: Cytochrome P450 20A1  
Size: 462 amino acids; 52432 Da
Cofactor: Heme group (By similarity)
Secondary accessions: Q4ZG61 Q8N4Q8 Q8WWA9

Explore the universe of human proteins at neXtProt for CYP20A1: NX_Q6UW02

Explore proteomics data for CYP20A1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CYP20A1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_803882.1  
    ENSEMBL proteins: 
     ENSP00000348380   ENSP00000414831   ENSP00000407860   ENSP00000398046   ENSP00000388070  
     ENSP00000411341  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CYP: Cytochrome P450s

    IUPHAR Guide to PHARMACOLOGY protein family classification: CYP20A1
    CYP11, CYP17, CYP19, CYP20 and CYP21 families

    2 InterPro protein domains:
     IPR001128 Cyt_P450
     IPR002401 Cyt_P450_E_grp-I

    Graphical View of Domain Structure for InterPro Entry Q6UW02

    ProtoNet protein and cluster: Q6UW02

    UniProtKB/Swiss-Prot: CP20A_HUMAN, Q6UW02
    Similarity: Belongs to the cytochrome P450 family


    CYP20A1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CP20A_HUMAN, Q6UW02
    Catalytic activity: RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O

         Enzyme Number (IUBMB): EC 1.14.-.-1

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004497monooxygenase activity IEA--
    GO:0005506iron ion binding IEA--
    GO:0016705oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA--
    GO:0020037heme binding IEA--
         
    CYP20A1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CYP20A1:
     Increased Salmonella enterica  

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Cyp20a1):
     cellular 

    CYP20A1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CYP20A1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CYP20A1
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    miRNA
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    miRTarBase miRNAs that target CYP20A1:
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    Block miRNA regulation of human, mouse, rat CYP20A1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CYP20A1 (see all 15):
    hsa-miR-4265 hsa-miR-299-5p hsa-miR-4291 hsa-miR-3163 hsa-miR-4307 hsa-miR-522 hsa-miR-340 hsa-miR-224*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Predesigned siRNA for gene silencing in human, mouse, rat CYP20A1

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    GenScript: all cDNA clones in your preferred vector: CYP20A1 (NM_177538)
    Sino Biological Human cDNA Clone for CYP20A1
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CYP20A1

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYP20A1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CP20A_HUMAN, Q6UW02: Membrane; Single-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum3
    cytosol1
    extracellular1
    mitochondrion1
    nucleus1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    CYP20A1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CYP20A1 About    
    See pathways by source

    SuperPathContained pathways About
    1Cytochrome P450 - arranged by substrate type
    cytochrome P4500.74
    2Biological oxidations
    metapathway biotransformation0.42


    2 BioSystems Pathways for CYP20A1
        cytochrome P450
    metapathway biotransformation



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CYP20A1
    Interactions:

        Search GeneGlobe Interaction Network for CYP20A1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    Selected Interacting proteins for CYP20A1 (Q6UW023 ENSP000003483804) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAPK6Q166593I2D: score=2 
    LSSENSP000003487624STRING: ENSP00000348762
    SIGMAR1ENSP000002770104STRING: ENSP00000277010
    SQLEENSP000002658964STRING: ENSP00000265896
    AGMOENSP000003416624STRING: ENSP00000341662
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0055114oxidation-reduction process ----

    CYP20A1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CYP20A1 (CP20A)

    1 HMDB Compound for CYP20A1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Heme(protoporphyrinato)iron (see all 19)14875-96-8--

    Selected Novoseek inferred chemical compound relationships for CYP20A1 gene (see all 40)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    2-nitronaphthalene 76.1 1 10319378 (1)
    4-ipomeanol 69.5 4 11291834 (2), 12487150 (1)
    epoxide 67.5 8 11178573 (1), 17566625 (1), 1638680 (1), 10521697 (1) (see all 5)
    etya 65.8 2 11952814 (1), 12957656 (1)
    7-ethoxycoumarin 64.3 1 2322313 (1)
    styrene oxide 61.2 6 17566625 (1), 11738271 (1), 12559694 (1), 12604177 (1)
    arachidonic acid 60.2 19 9056695 (2), 9645391 (1), 11125019 (1), 11952814 (1) (see all 16)
    ndga 56.8 5 9890957 (1), 17880512 (1), 1900289 (1), 11359783 (1)
    17-octadecynoic acid 55.8 2 15345486 (1), 11359783 (1)
    benzo(a)pyrene 55.6 2 15979946 (1), 17707923 (1)



    CYP20A1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CYP20A1 gene (2 alternative transcripts): 
    NM_177538.2  NM_020674.2  

    Unigene Cluster for CYP20A1:

    Cytochrome P450, family 20, subfamily A, polypeptide 1
    Hs.446065  [show with all ESTs]
    Unigene Representative Sequence: NM_177538
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000356079 ENST00000449301 ENST00000461371 ENST00000429815 ENST00000463131
    ENST00000428265 ENST00000489360 ENST00000431118(uc002uzv.4 uc002uzx.4 uc010zif.2 uc002uzy.4 uc002uzw.4 uc010ftw.3)
    ENST00000443941
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate CYP20A1 (see all 15):
    hsa-miR-4265 hsa-miR-299-5p hsa-miR-4291 hsa-miR-3163 hsa-miR-4307 hsa-miR-522 hsa-miR-340 hsa-miR-224*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Primer
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    Additional mRNA sequence: 

    AF183412.1 AK297082.1 AK307931.1 AL832998.1 AY359068.1 BC020616.1 

    21 DOTS entries:

    DT.92424647  DT.121000504  DT.100787316  DT.440474  DT.100728803  DT.446232  DT.432049  DT.95125811 
    DT.121000603  DT.121000462  DT.121000478  DT.95152502  DT.100746239  DT.91930835  DT.95089294  DT.97776386 
    DT.121000544  DT.40278215  DT.40297324  DT.75166306  DT.91639087 

    Selected AceView cDNA sequences (see all 130):

    BM718513 CR595024 T94055 NM_020674 AA962178 BM968188 BM683558 BI030829 
    AI005663 AI219384 AA400775 NM_177538 W31573 BM478190 AA405702 AY359068 
    CR590564 N73692 CA418270 AI016117 AA393407 AI651590 BQ643665 AW271691 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for CYP20A1    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b
    SP1:                                                                                          
    SP2:                                      -                                                   


    ECgene alternative splicing isoforms for CYP20A1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CYP20A1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCTTTGTGA
    CYP20A1 Expression
    About this image

    CYP20A1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CYP20A1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.446065
        Custom PCR Arrays for CYP20A1
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    QuantiFast Probe-based Assays in human, mouse, rat CYP20A1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYP20A1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CYP20A1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cyp20a11 , 5 cytochrome P450, family 20, subfamily a, polypeptide more1, 5 84.63(n)1
    83.12(a)1
      1 (30.47 cM)5
    779511  NM_030013.21  NP_084289.11 
     603433235 
    chicken
    (Gallus gallus)
    Aves CYP20A11 cytochrome P450, family 20, subfamily A, polypeptide more 72.09(n)
    73.97(a)
      431682  XM_426572.4  XP_426572.2 
    lizard
    (Anolis carolinensis)
    Reptilia CYP20A16
    cytochrome P450, family 20, subfamily A, polypepti...
    75(a)
    1 ↔ 1
    GL343208.1(3245339-3284489)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC528422 hypothetical protein MGC52842 74.46(n)    BC044111.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufa10c062 Danio rerio cDNA clone MGC63986 IMAGE6792484, complete more 70.57(n)    BC054588.1 


    ENSEMBL Gene Tree for CYP20A1 (if available)
    TreeFam Gene Tree for CYP20A1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CYP20A1 gene
    1 SIMAP similar gene for CYP20A1 using alignment to 8 protein entries:     CP20A_HUMAN (see all proteins):
    DKFZp666P073

    CYP20A1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CYP20A1 (see all 1308)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1873038361,2
    --203491193(+) CCTGGA/CCAAGT 1 -- us2k10--------
    rs67429001,2
    C,F,H--203491352(+) ATTTTC/AGATGT 1 -- us2k1 tfbs320Minor allele frequency- A:0.17NS EA NA WA CSA 2345
    rs1922032091,2
    --203491365(+) ATACAA/GAAAAT 1 -- us2k10--------
    rs1843985661,2
    --203491654(+) TACGGC/TACCTA 1 -- us2k10--------
    rs1452351111,2
    --203491666(+) GATTAC/TGGTTA 1 -- us2k10--------
    rs1159574971,2
    C,F--203491710(+) TTGGCC/TGGGCG 1 -- us2k11Minor allele frequency- T:0.17WA 118
    rs1471779051,2
    --203491790(+) AAGACC/GAGCCT 1 -- us2k10--------
    rs1875837371,2
    --203491868(+) GTAATA/CCCAGC 1 -- us2k10--------
    rs601670431,2
    C,F--203491981(+) ACTACG/ATCTCA 1 -- us2k13Minor allele frequency- A:0.07WA CSA 122
    rs1931022191,2
    --203492037(+) TGTTTC/TGAAAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CYP20A1 (204103164 - 204170563 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CYP20A1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2721371CNV Deletion23290073

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CYP20A1
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    15 diseases for CYP20A1:    
    About MalaCards
    fungal meningitis    scabies    meningitis    migraine
    colon adenocarcinoma    ischemia    hepatocellular carcinoma    nasopharyngitis
    hypertension    adenocarcinoma    breast cancer    endotheliitis
    pancreatitis    hepatitis    prostatitis


    CYP20A1 for disorders           About GeneDecksing

    5 Novoseek inferred disease relationships for CYP20A1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carcinoma bronchogenic 17.1 1 11291834 (1)
    tumors 2.46 2 9212475 (1), 8645428 (1)
    myocardial ischemia 0 1 14654065 (1)
    breast cancer 0 2 15350676 (2)
    hepatocellular carcinoma 0 3 9212475 (2), 11291834 (1)

    Genetic Association Database (GAD): CYP20A1
    Human Genome Epidemiology (HuGE) Navigator: CYP20A1 (2 documents)

    Export disorders for CYP20A1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CYP20A1 gene, integrated from 10 sources (see all 159):
    (articles sorted by number of sources associating them with CYP20A1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genome-wide association study of anthropometric traits and evidence of interactions with age and study year in Filipino women. (PubMed id 20966902)1, 4 Croteau-Chonka D.C....Mohlke K.L. (Obesity (Silver Spring) 2011)
    2. Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy. (PubMed id 19898482)1, 4 Ross C.J....Hayden M.R. (Nat. Genet. 2009)
    3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    5. Single-nucleotide polymorphisms, acute rejection, and severity of tubulitis in kidney transplantation, accounting for center-to-center variation. (PubMed id 21085059)4 Israni A....Oetting W.S. (Transplantation 2010)
    6. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W.... Wilson R.K. (Nature 2005)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. [Expression of cytochrome P450 enzymes in human nasopharyngeal carcinoma and non-cancerous nasopharynx tissue]. (PubMed id 15191668)1 Jiang J.H....Zeng Y.X. (Ai Zheng 2004)
    9. Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants. (PubMed id 15128046)1 Nelson D.R....Nebert D.W. (Pharmacogenetics 2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 57404 HGNC: 20576 AceView: CYP20A1 Ensembl:ENSG00000119004 euGenes: HUgn57404
    ECgene: CYP20A1 H-InvDB: CYP20A1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CYP20A1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CYP20A1 gene:
    Search GeneIP for patents involving CYP20A1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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