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Aliases for CYP20A1 Gene

Aliases for CYP20A1 Gene

  • Cytochrome P450, Family 20, Subfamily A, Polypeptide 1 2 3
  • Cytochrome P450 Monooxygenase 3
  • Cytochrome P450 20A1 3
  • EC 1.14.-.- 4
  • CYP-M 3

External Ids for CYP20A1 Gene

Previous GeneCards Identifiers for CYP20A1 Gene

  • GC02P202828
  • GC02P204067
  • GC02P204305
  • GC02P203928
  • GC02P203811
  • GC02P195951
  • GC02P204103

Summaries for CYP20A1 Gene

Entrez Gene Summary for CYP20A1 Gene

  • This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein lacks one amino acid of the conserved heme binding site. It also lacks the conserved I-helix motif AGX(D,E)T, suggesting that its substrate may carry its own oxygen. [provided by RefSeq, Jul 2008]

GeneCards Summary for CYP20A1 Gene

CYP20A1 (Cytochrome P450, Family 20, Subfamily A, Polypeptide 1) is a Protein Coding gene. Diseases associated with CYP20A1 include scabies. Among its related pathways are Biological oxidations and Cytochrome P450 - arranged by substrate type. GO annotations related to this gene include electron carrier activity and heme binding.

Gene Wiki entry for CYP20A1 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYP20A1 Gene

Genomics for CYP20A1 Gene

Regulatory Elements for CYP20A1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CYP20A1 Gene

203,238,441 bp from pter
203,305,840 bp from pter
67,400 bases
Plus strand

Genomic View for CYP20A1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CYP20A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYP20A1 Gene

Proteins for CYP20A1 Gene

  • Protein details for CYP20A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cytochrome P450 20A1
    Protein Accession:
    Secondary Accessions:
    • Q4ZG61
    • Q8N4Q8
    • Q8WWA9
    • Q9HC04

    Protein attributes for CYP20A1 Gene

    462 amino acids
    Molecular mass:
    52432 Da
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CYP20A1 Gene


neXtProt entry for CYP20A1 Gene

Proteomics data for CYP20A1 Gene at MOPED

Post-translational modifications for CYP20A1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for CYP20A1 Gene

Domains for CYP20A1 Gene

Gene Families for CYP20A1 Gene

Protein Domains for CYP20A1 Gene


Suggested Antigen Peptide Sequences for CYP20A1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the cytochrome P450 family.
  • Belongs to the cytochrome P450 family.
genes like me logo Genes that share domains with CYP20A1: view

Function for CYP20A1 Gene

Molecular function for CYP20A1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O

Enzyme Numbers (IUBMB) for CYP20A1 Gene

Gene Ontology (GO) - Molecular Function for CYP20A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004497 monooxygenase activity IEA --
GO:0005506 iron ion binding IEA --
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA --
GO:0020037 heme binding IEA --
genes like me logo Genes that share ontologies with CYP20A1: view

Phenotypes for CYP20A1 Gene

MGI mutant phenotypes for CYP20A1:
inferred from 1 alleles
GenomeRNAi human phenotypes for CYP20A1:
genes like me logo Genes that share phenotypes with CYP20A1: view

Animal Model Products

CRISPR Products

miRNA for CYP20A1 Gene

miRTarBase miRNAs that target CYP20A1

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for CYP20A1 Gene

Localization for CYP20A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYP20A1 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Jensen Localization Image for CYP20A1 Gene COMPARTMENTS Subcellular localization image for CYP20A1 gene
Compartment Confidence
endoplasmic reticulum 3
cytosol 1
extracellular 1
mitochondrion 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CYP20A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CYP20A1: view

Pathways for CYP20A1 Gene

genes like me logo Genes that share pathways with CYP20A1: view

Pathways by source for CYP20A1 Gene

2 BioSystems pathways for CYP20A1 Gene

Interacting Proteins for CYP20A1 Gene

Gene Ontology (GO) - Biological Process for CYP20A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with CYP20A1: view

Compounds for CYP20A1 Gene

(1) HMDB Compounds for CYP20A1 Gene

Compound Synonyms Cas Number PubMed IDs
  • (protoporphyrinato)iron

(40) Novoseek inferred chemical compound relationships for CYP20A1 Gene

Compound -log(P) Hits PubMed IDs
2-nitronaphthalene 76.1 1
4-ipomeanol 69.5 3
epoxide 67.5 5
etya 65.8 2
7-ethoxycoumarin 64.3 1
genes like me logo Genes that share compounds with CYP20A1: view

Transcripts for CYP20A1 Gene

Unigene Clusters for CYP20A1 Gene

Cytochrome P450, family 20, subfamily A, polypeptide 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CYP20A1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CYP20A1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b
SP2: -

Relevant External Links for CYP20A1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CYP20A1 Gene

mRNA expression in normal human tissues for CYP20A1 Gene

Protein differential expression in normal tissues for CYP20A1 Gene

This gene is overexpressed in Nasal epithelium (22.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CYP20A1 Gene

SOURCE GeneReport for Unigene cluster for CYP20A1 Gene Hs.446065

genes like me logo Genes that share expressions with CYP20A1: view

Expression partners for CYP20A1 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CYP20A1 Gene

Orthologs for CYP20A1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CYP20A1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CYP20A1 35
  • 90.62 (n)
  • 90.91 (a)
CYP20A1 36
  • 91 (a)
(Canis familiaris)
Mammalia LOC100686469 35
  • 90.73 (n)
  • 91.26 (a)
CYP20A1 36
  • 89 (a)
(Mus musculus)
Mammalia Cyp20a1 35
  • 84.63 (n)
  • 83.12 (a)
Cyp20a1 16
Cyp20a1 36
  • 83 (a)
(Pan troglodytes)
Mammalia CYP20A1 35
  • 99.57 (n)
  • 99.13 (a)
CYP20A1 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Cyp20a1 35
  • 83.77 (n)
  • 81.82 (a)
(Monodelphis domestica)
Mammalia CYP20A1 36
  • 81 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 75 (a)
-- 36
  • 81 (a)
(Gallus gallus)
Aves CYP20A1 35
  • 72.09 (n)
  • 73.97 (a)
CYP20A1 36
  • 74 (a)
(Anolis carolinensis)
Reptilia CYP20A1 36
  • 75 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cyp20a1 35
  • 69.92 (n)
  • 72.67 (a)
Str.3243 35
African clawed frog
(Xenopus laevis)
Amphibia MGC52842 35
(Danio rerio)
Actinopterygii cyp20a1 35
  • 64.28 (n)
  • 64.35 (a)
wufa10c06 35
cyp20a1 36
  • 64 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9531 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 26 (a)
CSA.1645 36
  • 26 (a)
Species with no ortholog for CYP20A1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CYP20A1 Gene

Gene Tree for CYP20A1 (if available)
Gene Tree for CYP20A1 (if available)

Paralogs for CYP20A1 Gene

(1) SIMAP similar genes for CYP20A1 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with CYP20A1: view

No data available for Paralogs for CYP20A1 Gene

Variants for CYP20A1 Gene

Sequence variations from dbSNP and Humsavar for CYP20A1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1651 -- 203,298,430(-) AGGCA(A/T)GAGCC utr-variant-3-prime
rs1653 -- 203,298,422(-) gccac(C/T)gagcc utr-variant-3-prime
rs1048013 - 203,289,829(+) CCCAG(C/T)TTCAA reference, missense
rs1469760 -- 203,260,703(+) gtttt(C/T)ggtag intron-variant
rs1594833 -- 203,276,355(+) gttac(A/C)atctg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CYP20A1 Gene

Variant ID Type Subtype PubMed ID
esv2721371 CNV Deletion 23290073

Relevant External Links for CYP20A1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CYP20A1 Gene

Disorders for CYP20A1 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for CYP20A1 Gene in MalaCards »

(1) Disease for CYP20A1 Gene

(5) Novoseek inferred disease relationships for CYP20A1 Gene

Disease -log(P) Hits PubMed IDs
carcinoma bronchogenic 17.1 1
tumors 2.46 2
myocardial ischemia 0 1
breast cancer 0 2
hepatocellular carcinoma 0 3

Relevant External Links for CYP20A1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with CYP20A1: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for CYP20A1 Gene

Publications for CYP20A1 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  2. Genome-wide association study of anthropometric traits and evidence of interactions with age and study year in Filipino women. (PMID: 20966902) Croteau-Chonka D.C. … Mohlke K.L. (Obesity (Silver Spring) 2011) 3 48
  3. Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy. (PMID: 19898482) Ross C.J. … Hayden M.R. (Nat. Genet. 2009) 3 48
  4. Defining the membrane proteome of NK cells. (PMID: 19946888) Ghosh D. … Wilkins J.A. (J Mass Spectrom 2010) 3
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3

Products for CYP20A1 Gene

Sources for CYP20A1 Gene

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