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Aliases for CYP20A1 Gene

Aliases for CYP20A1 Gene

  • Cytochrome P450, Family 20, Subfamily A, Polypeptide 1 2 3
  • Cytochrome P450 Monooxygenase 3
  • Cytochrome P450 20A1 3
  • EC 1.14.-.- 4
  • CYP-M 3

External Ids for CYP20A1 Gene

Summaries for CYP20A1 Gene

Entrez Gene Summary for CYP20A1 Gene

  • This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein lacks one amino acid of the conserved heme binding site. It also lacks the conserved I-helix motif AGX(D,E)T, suggesting that its substrate may carry its own oxygen. [provided by RefSeq, Jul 2008]

GeneCards Summary for CYP20A1 Gene

CYP20A1 (Cytochrome P450, Family 20, Subfamily A, Polypeptide 1) is a Protein Coding gene. Diseases associated with CYP20A1 include scabies. Among its related pathways are Biological oxidations and Cytochrome P450 - arranged by substrate type. GO annotations related to this gene include electron carrier activity and heme binding.

Gene Wiki entry for CYP20A1 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYP20A1 Gene

Genomics for CYP20A1 Gene

Genomic Location for CYP20A1 Gene

Start:
203,238,441 bp from pter
End:
203,305,840 bp from pter
Size:
67,400 bases
Orientation:
Plus strand

Genomic View for CYP20A1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CYP20A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYP20A1 Gene

Regulatory Elements for CYP20A1 Gene

Proteins for CYP20A1 Gene

  • Protein details for CYP20A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UW02-CP20A_HUMAN
    Recommended name:
    Cytochrome P450 20A1
    Protein Accession:
    Q6UW02
    Secondary Accessions:
    • Q4ZG61
    • Q8N4Q8
    • Q8WWA9
    • Q9HC04

    Protein attributes for CYP20A1 Gene

    Size:
    462 amino acids
    Molecular mass:
    52432 Da
    Cofactor:
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CYP20A1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CYP20A1 Gene

Proteomics data for CYP20A1 Gene at MOPED

Post-translational modifications for CYP20A1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CYP20A1 Gene

Domains for CYP20A1 Gene

Gene Families for CYP20A1 Gene

HGNC:
  • CYP :Cytochrome P450s
IUPHAR :

Protein Domains for CYP20A1 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

CP20A_HUMAN
Family:
  • Belongs to the cytochrome P450 family.:
    • Q6UW02
genes like me logo Genes that share domains with CYP20A1: view

Function for CYP20A1 Gene

Molecular function for CYP20A1 Gene

UniProtKB/Swiss-Prot CatalyticActivity: RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O

Enzyme Numbers (IUBMB) for CYP20A1 Gene

Gene Ontology (GO) - Molecular Function for CYP20A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004497 monooxygenase activity IEA --
GO:0005506 iron ion binding IEA --
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA --
GO:0020037 heme binding IEA --
genes like me logo Genes that share ontologies with CYP20A1: view

Phenotypes for CYP20A1 Gene

MGI mutant phenotypes for CYP20A1:
inferred from 1 alleles
GenomeRNAi human phenotypes for CYP20A1:
genes like me logo Genes that share phenotypes with CYP20A1: view

miRNA for CYP20A1 Gene

miRTarBase miRNAs that target CYP20A1

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for CYP20A1 Gene

Localization for CYP20A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYP20A1 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CYP20A1 Gene COMPARTMENTS Subcellular localization image for CYP20A1 gene
Compartment Confidence
endoplasmic reticulum 3
cytosol 1
extracellular 1
mitochondrion 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CYP20A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CYP20A1: view

Pathways for CYP20A1 Gene

genes like me logo Genes that share pathways with CYP20A1: view

Pathways by source for CYP20A1 Gene

2 BioSystems pathways for CYP20A1 Gene

Interacting Proteins for CYP20A1 Gene

Gene Ontology (GO) - Biological Process for CYP20A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with CYP20A1: view

Compounds for CYP20A1 Gene

(1) HMDB Compounds for CYP20A1 Gene

Compound Synonyms Cas Number PubMed IDs
Heme
  • (protoporphyrinato)iron
14875-96-8

(40) Novoseek inferred chemical compound relationships for CYP20A1 Gene

Compound -log(P) Hits PubMed IDs
2-nitronaphthalene 76.1 1
4-ipomeanol 69.5 3
epoxide 67.5 5
etya 65.8 2
7-ethoxycoumarin 64.3 1
genes like me logo Genes that share compounds with CYP20A1: view

Transcripts for CYP20A1 Gene

Unigene Clusters for CYP20A1 Gene

Cytochrome P450, family 20, subfamily A, polypeptide 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CYP20A1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b
SP1:
SP2: -

Relevant External Links for CYP20A1 Gene

GeneLoc Exon Structure for
CYP20A1
ECgene alternative splicing isoforms for
CYP20A1

Expression for CYP20A1 Gene

mRNA expression in normal human tissues for CYP20A1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CYP20A1 Gene

SOURCE GeneReport for Unigene cluster for CYP20A1 Gene Hs.446065

genes like me logo Genes that share expressions with CYP20A1: view

Orthologs for CYP20A1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CYP20A1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CYP20A1 36
  • 99.57 (n)
  • 99.13 (a)
CYP20A1 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CYP20A1 36
  • 90.62 (n)
  • 90.91 (a)
CYP20A1 37
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CYP20A1 37
  • 89 (a)
OneToOne
LOC100686469 36
  • 90.73 (n)
  • 91.26 (a)
mouse
(Mus musculus)
Mammalia Cyp20a1 36
  • 84.63 (n)
  • 83.12 (a)
Cyp20a1 16
Cyp20a1 37
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CYP20A1 37
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 75 (a)
OneToMany
-- 37
  • 81 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Cyp20a1 36
  • 83.77 (n)
  • 81.82 (a)
chicken
(Gallus gallus)
Aves CYP20A1 36
  • 72.09 (n)
  • 73.97 (a)
CYP20A1 37
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CYP20A1 37
  • 75 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC52842 36
tropical clawed frog
(Silurana tropicalis)
Amphibia cyp20a1 36
  • 69.92 (n)
  • 72.67 (a)
Str.3243 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9531 36
zebrafish
(Danio rerio)
Actinopterygii cyp20a1 36
  • 64.28 (n)
  • 64.35 (a)
cyp20a1 37
  • 64 (a)
OneToOne
wufa10c06 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 26 (a)
OneToMany
CSA.1645 37
  • 26 (a)
OneToMany
Species with no ortholog for CYP20A1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CYP20A1 Gene

ENSEMBL:
Gene Tree for CYP20A1 (if available)
TreeFam:
Gene Tree for CYP20A1 (if available)

Paralogs for CYP20A1 Gene

Selected SIMAP similar genes for CYP20A1 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with CYP20A1: view

No data available for Paralogs for CYP20A1 Gene

Variants for CYP20A1 Gene

Sequence variations from dbSNP and Humsavar for CYP20A1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1651 -- 203,298,430(-) AGGCA(A/T)GAGCC utr-variant-3-prime
rs1653 -- 203,298,422(-) gccac(C/T)gagcc utr-variant-3-prime
rs1048013 - 203,289,829(+) CCCAG(C/T)TTCAA reference, missense
rs1469760 -- 203,260,703(+) gtttt(C/T)ggtag intron-variant
rs1594833 -- 203,276,355(+) gttac(A/C)atctg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CYP20A1 Gene

Variant ID Type Subtype PubMed ID
esv2721371 CNV Deletion 23290073

Relevant External Links for CYP20A1 Gene

HapMap Linkage Disequilibrium report
CYP20A1

Disorders for CYP20A1 Gene

(1) MalaCards Diseases for CYP20A1 Gene

Search for CYP20A1 Gene in MalaCards »

(5) Novoseek inferred disease relationships for CYP20A1 Gene

Disease -log(P) Hits PubMed IDs
carcinoma bronchogenic 17.1 1
tumors 2.46 2
myocardial ischemia 0 1
breast cancer 0 2
hepatocellular carcinoma 0 3

Relevant External Links for CYP20A1

Genetic Association Database (GAD)
CYP20A1
Human Genome Epidemiology (HuGE) Navigator
CYP20A1
genes like me logo Genes that share disorders with CYP20A1: view

No data available for UniProtKB/Swiss-Prot for CYP20A1 Gene

Publications for CYP20A1 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  2. Genome-wide association study of anthropometric traits and evidence of interactions with age and study year in Filipino women. (PMID: 20966902) Croteau-Chonka D.C. … Mohlke K.L. (Obesity (Silver Spring) 2011) 3 49
  3. Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy. (PMID: 19898482) Ross C.J. … Hayden M.R. (Nat. Genet. 2009) 3 49
  4. Defining the membrane proteome of NK cells. (PMID: 19946888) Ghosh D. … Wilkins J.A. (J Mass Spectrom 2010) 3
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3

Products for CYP20A1 Gene

Sources for CYP20A1 Gene

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