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Aliases for CYP20A1 Gene

Aliases for CYP20A1 Gene

  • Cytochrome P450, Family 20, Subfamily A, Polypeptide 1 2 3
  • Cytochrome P450 Monooxygenase 3
  • EC 1.14.-.- 4
  • CYP-M 3

External Ids for CYP20A1 Gene

Previous GeneCards Identifiers for CYP20A1 Gene

  • GC02P202828
  • GC02P204067
  • GC02P204305
  • GC02P203928
  • GC02P203811
  • GC02P195951
  • GC02P204103

Summaries for CYP20A1 Gene

Entrez Gene Summary for CYP20A1 Gene

  • This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein lacks one amino acid of the conserved heme binding site. It also lacks the conserved I-helix motif AGX(D,E)T, suggesting that its substrate may carry its own oxygen. [provided by RefSeq, Jul 2008]

GeneCards Summary for CYP20A1 Gene

CYP20A1 (Cytochrome P450, Family 20, Subfamily A, Polypeptide 1) is a Protein Coding gene. Diseases associated with CYP20A1 include bronchus carcinoma. Among its related pathways are Biological oxidations and Cytochrome P450 - arranged by substrate type. GO annotations related to this gene include iron ion binding and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen.

Gene Wiki entry for CYP20A1 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYP20A1 Gene

Genomics for CYP20A1 Gene

Regulatory Elements for CYP20A1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CYP20A1 Gene

Chromosome:
2
Start:
203,238,441 bp from pter
End:
203,305,840 bp from pter
Size:
67,400 bases
Orientation:
Plus strand

Genomic View for CYP20A1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CYP20A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYP20A1 Gene

Proteins for CYP20A1 Gene

  • Protein details for CYP20A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UW02-CP20A_HUMAN
    Recommended name:
    Cytochrome P450 20A1
    Protein Accession:
    Q6UW02
    Secondary Accessions:
    • Q4ZG61
    • Q8N4Q8
    • Q8WWA9
    • Q9HC04

    Protein attributes for CYP20A1 Gene

    Size:
    462 amino acids
    Molecular mass:
    52432 Da
    Cofactor:
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CYP20A1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CYP20A1 Gene

Proteomics data for CYP20A1 Gene at MOPED

Post-translational modifications for CYP20A1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for CYP20A1 Gene

Domains & Families for CYP20A1 Gene

Gene Families for CYP20A1 Gene

Protein Domains for CYP20A1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CYP20A1 Gene

Graphical View of Domain Structure for InterPro Entry

Q6UW02

UniProtKB/Swiss-Prot:

CP20A_HUMAN :
  • Belongs to the cytochrome P450 family.
Family:
  • Belongs to the cytochrome P450 family.
genes like me logo Genes that share domains with CYP20A1: view

Function for CYP20A1 Gene

Molecular function for CYP20A1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O

Enzyme Numbers (IUBMB) for CYP20A1 Gene

Gene Ontology (GO) - Molecular Function for CYP20A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004497 monooxygenase activity IEA --
GO:0005506 iron ion binding IEA --
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA --
GO:0020037 heme binding IEA --
genes like me logo Genes that share ontologies with CYP20A1: view

Phenotypes for CYP20A1 Gene

genes like me logo Genes that share phenotypes with CYP20A1: view

Animal Model Products

CRISPR Products

miRNA for CYP20A1 Gene

miRTarBase miRNAs that target CYP20A1

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for CYP20A1 Gene

Localization for CYP20A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYP20A1 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CYP20A1 Gene COMPARTMENTS Subcellular localization image for CYP20A1 gene
Compartment Confidence
cytoskeleton 2
nucleus 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for CYP20A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CYP20A1: view

Pathways & Interactions for CYP20A1 Gene

genes like me logo Genes that share pathways with CYP20A1: view

Pathways by source for CYP20A1 Gene

2 BioSystems pathways for CYP20A1 Gene

Interacting Proteins for CYP20A1 Gene

Gene Ontology (GO) - Biological Process for CYP20A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with CYP20A1: view

No data available for SIGNOR curated interactions for CYP20A1 Gene

Drugs & Compounds for CYP20A1 Gene

(14) Drugs for CYP20A1 Gene - From: NovoSeek and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Enflurane Approved Pharma 2
Indomethacin Approved, Investigational Pharma Inhibition, Inhibitor Cox inhibitor 97
Nitric Oxide Approved Pharma 540
Permethrin Approved, Investigational Pharma 25
Phenobarbital Approved Pharma Agonist 33

(28) Additional Compounds for CYP20A1 Gene - From: NovoSeek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
oxygen
  • Dioxygen
  • Molecular oxygen
  • O2
  • Oxygen
  • Oxygen molecule
7782-44-7
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
17-octadecynoic acid
20-Hydroxyeicosatetraenoic acid
  • (5Z,8Z,11Z,14Z)-20-Hydroxyicosa-5,8,11,14-tetraenoate
  • (5Z,8Z,11Z,14Z)-20-Hydroxyicosa-5,8,11,14-tetraenoic acid
  • (all-Z)-20-hydroxy-5,8,11,14-Eicosatetraenoate
  • (all-Z)-20-hydroxy-5,8,11,14-Eicosatetraenoic acid
  • 20-HETE
79551-86-3
2-NITRONAPHTHALENE
genes like me logo Genes that share compounds with CYP20A1: view

Transcripts for CYP20A1 Gene

Unigene Clusters for CYP20A1 Gene

Cytochrome P450, family 20, subfamily A, polypeptide 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CYP20A1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CYP20A1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b
SP1:
SP2: -

Relevant External Links for CYP20A1 Gene

GeneLoc Exon Structure for
CYP20A1
ECgene alternative splicing isoforms for
CYP20A1

Expression for CYP20A1 Gene

mRNA expression in normal human tissues for CYP20A1 Gene

Protein differential expression in normal tissues from HIPED for CYP20A1 Gene

This gene is overexpressed in Nasal epithelium (22.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CYP20A1 Gene



SOURCE GeneReport for Unigene cluster for CYP20A1 Gene Hs.446065

genes like me logo Genes that share expression patterns with CYP20A1: view

Protein tissue co-expression partners for CYP20A1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CYP20A1 Gene

Orthologs for CYP20A1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CYP20A1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CYP20A1 35
  • 90.62 (n)
  • 90.91 (a)
CYP20A1 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC100686469 35
  • 90.73 (n)
  • 91.26 (a)
CYP20A1 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cyp20a1 35
  • 84.63 (n)
  • 83.12 (a)
Cyp20a1 16
Cyp20a1 36
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CYP20A1 35
  • 99.57 (n)
  • 99.13 (a)
CYP20A1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cyp20a1 35
  • 83.77 (n)
  • 81.82 (a)
oppossum
(Monodelphis domestica)
Mammalia CYP20A1 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 75 (a)
OneToMany
-- 36
  • 81 (a)
OneToMany
chicken
(Gallus gallus)
Aves CYP20A1 35
  • 72.09 (n)
  • 73.97 (a)
CYP20A1 36
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CYP20A1 36
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cyp20a1 35
  • 69.92 (n)
  • 72.67 (a)
Str.3243 35
African clawed frog
(Xenopus laevis)
Amphibia MGC52842 35
zebrafish
(Danio rerio)
Actinopterygii cyp20a1 35
  • 64.28 (n)
  • 64.35 (a)
wufa10c06 35
cyp20a1 36
  • 64 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9531 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 26 (a)
OneToMany
CSA.1645 36
  • 26 (a)
OneToMany
Species with no ortholog for CYP20A1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CYP20A1 Gene

ENSEMBL:
Gene Tree for CYP20A1 (if available)
TreeFam:
Gene Tree for CYP20A1 (if available)

Paralogs for CYP20A1 Gene

(1) SIMAP similar genes for CYP20A1 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with CYP20A1: view

No data available for Paralogs for CYP20A1 Gene

Variants for CYP20A1 Gene

Sequence variations from dbSNP and Humsavar for CYP20A1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1651 -- 203,298,430(-) AGGCA(A/T)GAGCC utr-variant-3-prime, downstream-variant-500B
rs1653 -- 203,298,422(-) gccac(C/T)gagcc utr-variant-3-prime, downstream-variant-500B
rs1048013 - 203,289,829(+) CCCAG(C/T)TTCAA reference, missense, nc-transcript-variant
rs1469760 -- 203,260,703(+) gtttt(C/T)ggtag intron-variant
rs1594833 -- 203,276,355(+) gttac(A/C)atctg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CYP20A1 Gene

Variant ID Type Subtype PubMed ID
esv2721371 CNV Deletion 23290073

Variation tolerance for CYP20A1 Gene

Residual Variation Intolerance Score: 83.23% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.76; 94.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CYP20A1 Gene

HapMap Linkage Disequilibrium report
CYP20A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CYP20A1 Gene

Disorders for CYP20A1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CYP20A1 Gene - From: NovoSeek

Disorder Aliases PubMed IDs
bronchus carcinoma
  • bc - bronchogenic carcinoma
- elite association

Relevant External Links for CYP20A1

Genetic Association Database (GAD)
CYP20A1
Human Genome Epidemiology (HuGE) Navigator
CYP20A1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CYP20A1
genes like me logo Genes that share disorders with CYP20A1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CYP20A1 Gene

Publications for CYP20A1 Gene

  1. Density functional theory applied to a difference in pathways taken by the enzymes cytochrome P450 and superoxide reductase: spin States of ferric hydroperoxo intermediates and hydrogen bonds from water. (PMID: 19968237) Surawatanawong P. … Hall M.B. (Inorg Chem 2010) 23 67
  2. Sorgoleone. (PMID: 20385394) Dayan F.E. … Duke S.O. (Phytochemistry 2010) 23 67
  3. The use of liposomes in the study of drug metabolism: a method to incorporate the enzymes of the cytochrome p450 monooxygenase system into phospholipid, bilayer vesicles. (PMID: 20013386) Reed J.R. (Methods Mol. Biol. 2010) 23 67
  4. Terpenoid biosynthesis and specialized vascular cells of conifer defense. (PMID: 20074143) Zulak K.G. … Bohlmann J. (J Integr Plant Biol 2010) 23 67
  5. Oxidation of the endogenous cannabinoid arachidonoyl ethanolamide by the cytochrome P450 monooxygenases: physiological and pharmacological implications. (PMID: 20133390) Snider N.T. … Hollenberg P.F. (Pharmacol. Rev. 2010) 23 67

Products for CYP20A1 Gene

Sources for CYP20A1 Gene

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