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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CYP20A1 Gene

protein-coding   GIFtS: 51
GCID: GC02P204103

cytochrome P450, family 20, subfamily A, polypeptide 1

 Explore 18 diseases affiliated with
CYP20A1 via our new
 Human Malady Compendium 
Biological research products
for CYP20A1
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Cytochrome P450, Family 20, Subfamily A, Polypeptide 11 2
CYP-M1 2
Cytochrome P450 20A12
Cytochrome P450 Monooxygenase2
EC 1.14.-.-3

External Ids:    HGNC: 205761   Entrez Gene: 574042   Ensembl: ENSG000001190047   UniProtKB: Q6UW023   

Export aliases for CYP20A1 gene to outside databases

Previous GC identifers: GC02P202828 GC02P204067 GC02P204305 GC02P203928 GC02P203811 GC02P195951


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CYP20A1:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are
monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and
other lipids. This protein lacks one amino acid of the conserved heme binding site. It also lacks the conserved
I-helix motif AGX(D,E)T, suggesting that its substrate may carry its own oxygen. (provided by RefSeq, Jul 2008)

Gene Wiki entry for CYP20A1


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_005403.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CYP20A1 gene promoter:
         Bach1   NF-1   AML1a   POU3F1   HNF-1A   Evi-1   Nkx6-1   POU2F1   POU2F1a   HNF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCYP20A1 promoter sequence
   Search SABiosciences Chromatin IP Primers for CYP20A1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CYP20A1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q33.2   Ensembl cytogenetic band:  2q33.2   HGNC cytogenetic band: 2q33

CYP20A1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CYP20A1 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P204103:  view genomic region     (about GC identifiers)

Start:
204,103,164 bp from pter      End:
204,170,563 bp from pter
Size:
67,400 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CP20A_HUMAN, Q6UW02 (See protein sequence)
Recommended Name: Cytochrome P450 20A1  
Size: 462 amino acids; 52432 Da
Cofactor: Heme group (By similarity)
Subcellular location: Membrane; Single-pass membrane protein (Potential)
Secondary accessions: Q4ZG61 Q8N4Q8 Q8WWA9

Explore the universe of human proteins at neXtProt for CYP20A1: NX_Q6UW02

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q6UW02

  • CYP20A1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_803882.1  
    ENSEMBL proteins: 
     ENSP00000348380   ENSP00000414831   ENSP00000407860   ENSP00000398046   ENSP00000388070  
     ENSP00000411341  

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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for CYP20A1

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--


    CYP20A1 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    CYP20A1 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR001128 Cyt_P450
     IPR002401 Cyt_P450_E_grp-I

    Graphical View of Domain Structure for InterPro Entry Q6UW02

    ProtoNet protein and cluster: Q6UW02

    UniProtKB/Swiss-Prot: CP20A_HUMAN, Q6UW02
    Similarity: Belongs to the cytochrome P450 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: CP20A_HUMAN, Q6UW02
    Catalytic activity: RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O

    Enzyme Number (IUBMB): EC 1.14.-.-1

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    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004497monooxygenase activity IEA--
    GO:0005506iron ion binding IEA--
    GO:0009055electron carrier activity IEA--
    GO:0016705oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA--
    GO:0020037heme binding IEA--


    CYP20A1 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for CYP20A1:
     Increased Salmonella enterica  


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Cytochrome P450 - arranged by substrate type
    cytochrome P4500.73
    2Biological oxidations
    metapathway biotransformation0.41


    2 BioSystems Pathways for CYP20A1 
        cytochrome P450
    metapathway biotransformation


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CYP20A1

    1 Interacting protein for CYP20A1 (Q6UW023) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAPK6Q166593I2D: score=2 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CYP20A1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CYP20A1

    1 HMDB Compound for CYP20A1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Heme(protoporphyrinato)iron (see all 19)14875-96-8--
    10/40 Novoseek chemical compound relationships for CYP20A1 gene (see all 40)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    2-nitronaphthalene 76.1 1 10319378 (1)
    4-ipomeanol 69.5 4 11291834 (2), 12487150 (1)
    epoxide 67.5 8 11178573 (1), 17566625 (1), 1638680 (1), 10521697 (1) (see all 5)
    etya 65.8 2 11952814 (1), 12957656 (1)
    7-ethoxycoumarin 64.3 1 2322313 (1)
    styrene oxide 61.2 6 17566625 (1), 11738271 (1), 12559694 (1), 12604177 (1)
    arachidonic acid 60.2 19 9056695 (2), 9645391 (1), 11125019 (1), 11952814 (1) (see all 16)
    ndga 56.8 5 9890957 (1), 17880512 (1), 1900289 (1), 11359783 (1)
    17-octadecynoic acid 55.8 2 15345486 (1), 11359783 (1)
    benzo(a)pyrene 55.6 2 15979946 (1), 17707923 (1)

    Search CenterWatch for drugs/clinical trials and news about CYP20A1 / CP20A 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CYP20A1 gene (2 alternative transcripts): 
    NM_177538.2  NM_020674.2  

    Unigene Cluster for CYP20A1:

    Cytochrome P450, family 20, subfamily A, polypeptide 1
    Hs.446065  [show with all ESTs]
    Unigene Representative Sequence: NM_177538
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000356079 ENST00000449301 ENST00000461371 ENST00000429815 ENST00000463131
    ENST00000428265 ENST00000489360 ENST00000431118(uc002uzv.4 uc002uzx.4 uc010zif.2 uc002uzy.4 uc002uzw.4 uc010ftw.3)
    ENST00000443941

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    Additional cDNA sequence: 

    AF183412.1 AK297082.1 AK307931.1 AL832998.1 AY359068.1 BC020616.1 

    21 DOTS entries:

    DT.92424647  DT.121000504  DT.100787316  DT.440474  DT.100728803  DT.446232  DT.432049  DT.95125811 
    DT.121000603  DT.121000462  DT.121000478  DT.95152502  DT.100746239  DT.91930835  DT.95089294  DT.97776386 
    DT.121000544  DT.40278215  DT.40297324  DT.75166306  DT.91639087 

    24/130 AceView cDNA sequences (see all 130):

    BM718513 CA418270 CR590564 AI016117 BI030829 AA400775 NM_177538 BM478190 
    W31573 N73692 AA962178 AY359068 CR595024 AI219384 AI005663 NM_020674 
    BM968188 AA405702 BM683558 T94055 CD699897 AW466887 CA445560 BG576266 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for CYP20A1    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b
    SP1:                                                                                          
    SP2:                                      -                                                   


    ECgene alternative splicing isoforms for CYP20A1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CYP20A1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGCTTTGTGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See CYP20A1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CYP20A1

    SOURCE GeneReport for Unigene cluster: Hs.446065
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CYP20A1 gene from 5/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cyp20a11 , 5 cytochrome P450, family 20, subfamily a, polypeptide more1, 5 84.63(n)1
    83.12(a)1
      1 (30.47 cM)5
    779511  NM_030013.21  NP_084289.11 
     603433235 
    chicken
    (Gallus gallus)
    Aves CYP20A11 cytochrome P450, family 20, subfamily A, polypeptide more 72.09(n)
    73.97(a)
      431682  XM_426572.3  XP_426572.2 
    lizard
    (Anolis carolinensis)
    Reptilia CYP20A16
    --
    75(a)
    1 ↔ 1
    GL343208.1(3245339-3284489)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC528422 hypothetical protein MGC52842 74.46(n)    BC044111.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufa10c062 Danio rerio cDNA clone MGC63986 IMAGE6792484, complete more 70.57(n)    BC054588.1 


    ENSEMBL Gene Tree for CYP20A1 (if available)
    TreeFam Gene Tree for CYP20A1 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1062 NCBI SNPs in CYP20A1 are shown (see all 1062    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1873038361,2
    --204101169(+) CCTGGA/CCAAGT 1 -- us2k10--------
    rs67429001,2
    C,F,H,--204101328(+) ATTTTC/AGATGT 1 -- us2k1 tfbs320Minor allele frequency- A:0.17NS EA NA WA CSA 2345
    rs1922032091,2
    --204101341(+) ATACAA/GAAAAT 1 -- us2k10--------
    rs1843985661,2
    --204101630(+) TACGGC/TACCTA 1 -- us2k10--------
    rs1452351111,2
    --204101642(+) GATTAC/TGGTTA 1 -- us2k10--------
    rs1159574971,2
    C,F,--204101686(+) TTGGCC/TGGGCG 1 -- us2k11Minor allele frequency- T:0.17WA 118
    rs1471779051,2
    --204101766(+) AAGACC/GAGCCT 1 -- us2k10--------
    rs1875837371,2
    --204101844(+) GTAATA/CCCAGC 1 -- us2k10--------
    rs601670431,2
    C,F,--204101957(+) ACTACG/ATCTCA 1 -- us2k13Minor allele frequency- A:0.07WA CSA 122
    rs1931022191,2
    --204102013(+) TGTTTC/TGAAAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CYP20A1 (204103164 - 204170563 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for CYP20A1: --

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    CYP20A1 for disorders           About GeneDecksing

    18 diseases for CYP20A1:    About MalaCards
    fungal meningitis    scabies    hearing loss    hepatocellular carcinoma
    cholesterol    colon adenocarcinoma    migraine    breast cancer
    meningitis    homocysteine    nasopharyngitis    adenocarcinoma
    carcinoma    hypertension    pancreatitis    hepatitis
    prostatitis    alcoholism

    5 Novoseek disease relationships for CYP20A1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carcinoma bronchogenic 17.1 1 11291834 (1)
    tumors 2.46 2 9212475 (1), 8645428 (1)
    myocardial ischemia 0 1 14654065 (1)
    breast cancer 0 2 15350676 (2)
    hepatocellular carcinoma 0 3 9212475 (2), 11291834 (1)

    Human Genome Epidemiology (HuGE) Navigator: CYP20A1 (2 documents)

    Export disorders for CYP20A1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CYP20A1 gene, integrated from 9 sources (see all 158):
    (articles sorted by number of sources associating them with CYP20A1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    2. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    3. Genome-Wide Association Study of Anthropometric Trait s and Evidence of Interactions With Age and Study Year in Filipino Women. (PubMed id 20966902)1 Croteau-Chonka D.C....Mohlke K.L. (2010)
    4. Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy. (PubMed id 19898482)1 Ross C.J....Hayden M.R. (2009)
    5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
    7. [Expression of cytochrome P450 enzymes in human nasopharyngeal carcinoma and non-cancerous nasopharynx tissue] (PubMed id 15191668)1 Jiang J.H....Zeng Y.X. (2004)
    8. Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants. (PubMed id 15128046)1 Nelson D.R....Nebert D.W. (2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57404 HGNC: 20576 AceView: CYP20A1 Ensembl:ENSG00000119004 euGenes: HUgn57404
    ECgene: CYP20A1 H-InvDB: CYP20A1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CYP20A1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CYP20A1 gene:
    Search GeneIP for patents involving CYP20A1

    GeneCards and IP:
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