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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CYP1A2 Gene

protein-coding GIFtS: 70
GCID: GC15P075041

cytochrome P450, family 1, subfamily A, polypeptide 2

(Previous names: cytochrome P450, subfamily I (aromatic compound-inducible),...)

Explore 107 diseases affiliated with
CYP1A2 via

MalaCards

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Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Cytochrome P450, Family 1, Subfamily A, Polypeptide 2¹ ²		P450(PA)²
CP12¹ ²		Aryl Hydrocarbon Hydroxylase²
P3-450¹ ²		Cytochrome P450 1A2²
Cytochrome P450, Subfamily I (Aromatic Compound-Inducible), Polypeptide 2¹ ²		Dioxin-Inducible P3-450²
Cytochrome P(3)450² ³		Flavoprotein-Linked Monooxygenase²
Cytochrome P450 4² ³		Microsomal Monooxygenase²
Cytochrome P450-P3² ³		P450 Form 4²
CYPIA2² ³		Xenobiotic Monooxygenase²
EC 1.14.14.1³ ⁸

External Ids:	HGNC: 2596¹	Entrez Gene: 1544²	Ensembl: ENSG00000140505⁷	OMIM: 124060⁵	UniProtKB: P05177³

Export aliases for CYP1A2 gene to outside databases

Previous GC identifers: GC15M070968 GC15M068160 GC15P072617 GC15P072757 GC15P072828 GC15P051838

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CYP1A2:

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are

monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and

other lipids. The protein encoded by this gene localizes to the endoplasmic reticulum and its expression is induced by

some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous

substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. Other xenobiotic

substrates for this enzyme include caffeine, aflatoxin B1, and acetaminophen. The transcript from this gene contains

four Alu sequences flanked by direct repeats in the 3' untranslated region. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CP1A2_HUMAN, P05177

Function: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in

an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including

steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily

by cytochrome CYP1A2 in the liver through an initial N3-demethylation. Also acts in the metabolism of aflatoxin B1 and

acetaminophen. Participates in the bioactivation of carcinogenic aromatic and heterocyclic amines. Catalizes the

N-hydroxylation of heterocyclic amines and the O-deethylation of phenacetin

Gene Wiki entry for CYP1A2

PharmGKB "VIP" summary for CYP1A2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000015.9 NC_018926.1 NT_010194.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CYP1A2 gene promoter:
GR p53 Pax-2 Nkx5-1 Arnt C/EBPalpha HNF-4alpha1 MZF-1 Ik-2 GR-alpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CYP1A2 promoter sequence

Search SABiosciences Chromatin IP Primers for CYP1A2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CYP1A2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q24.1 Ensembl cytogenetic band: 15q24.1 HGNC cytogenetic band: 15q24.1

CYP1A2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CYP1A2 gene location

GeneLoc information about chromosome 15 GeneLoc Exon Structure

GeneLoc location for GC15P075041: view genomic region (about GC identifiers)

Start:	75,041,184 bp from pter	End:	75,048,941 bp from pter
Size:	7,758 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CP1A2_HUMAN, P05177 (See protein sequence)

Recommended Name: Cytochrome P450 1A2

Size: 515 amino acids; 58294 Da

Cofactor: Heme group

Subcellular location: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral

membrane protein

1 PDB 3D structure from and Proteopedia for CYP1A2:

2HI4 (3D)

Secondary accessions: Q16754 Q6NWU5 Q9BXX7 Q9UK49

Alternative splicing: 2 isoforms: P05177-1 P05177-2

Explore the universe of human proteins at neXtProt for CYP1A2: NX_P05177

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P05177

4/25 DME Specific Peptides for CYP1A2 (P05177) (see all 25)

LEAFILE

FSIASDP

PILRYLP

YLPNPAL

CYP1A2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_000752.2

ENSEMBL proteins:

ENSP00000342007

Reactome Protein details: P05177
Human Recombinant Protein Products:

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	Uscn Proteins for CYP1A2

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005789	endoplasmic reticulum membrane	TAS	--
GO:0005792	microsome	--	--
GO:0043231	intracellular membrane-bounded organelle	IDA	2813353

CYP1A2 for ontologies About GeneDecksing

CYP1A2 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of CYP1A2
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	Uscn Antibodies for CYP1A2
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Assay Products for CYP1A2:

	Browse Kits and Assays available from EMD Millipore
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	Uscn ELISAs and CLIAs for CYP1A2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CYP1A2 for domains About GeneDecksing

4 InterPro domains/families:

IPR001128 Cyt_P450

IPR017972 Cyt_P450_CS

IPR002401 Cyt_P450_E_grp-I

IPR008066 Cyt_P450_E_grp-I_CYP1

Graphical View of Domain Structure for InterPro Entry P05177

ProtoNet protein and cluster: P05177

2 Blocks protein families:

IPB002401 E-class P450 group I signature

IPB008066 CYP1A P450 family signature

UniProtKB/Swiss-Prot: CP1A2_HUMAN, P05177

Similarity: Belongs to the cytochrome P450 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: CP1A2_HUMAN, P05177

Function: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in

an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including

steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily

by cytochrome CYP1A2 in the liver through an initial N3-demethylation. Also acts in the metabolism of aflatoxin B1 and

acetaminophen. Participates in the bioactivation of carcinogenic aromatic and heterocyclic amines. Catalizes the

N-hydroxylation of heterocyclic amines and the O-deethylation of phenacetin

Catalytic activity: RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O

Biophysicochemical properties: Kinetic parameters: KM=4 uM for 2-amino-6-methyldipyrido[1,2-a:3',2'-d]imidazole; KM=21

uM for 2-amino-3-methylimidazo[4,5-f]quinoline; KM=26 uM for 2-amino-2,4-dimethylimidazo[4,5-f]quinoline; KM=27 uM for

2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline; KM=71 uM for 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine; KM=25 uM

for phenacetin;

Induction: By nicotine, omeprazole, phenobarbital, primidone and rifampicin

Genatlas biochemistry entry for CYP1A2:

cytochrome p450,family I (aromatic compound-inducible),member A2 (see CYP1@)

Enzyme Number (IUBMB): EC 1.14.14.1¹ ²

miRNA Products:		OriGene 3'-UTR Clone: CYP1A2 Browse MicroRNA Expression Plasmids
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Gene Editing
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYP1A2

Gene Ontology (GO): 5/10 molecular function terms (GO ID links to tree view) (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004497	monooxygenase activity	IDA	15327587
GO:0005506	iron ion binding	IEA	--
GO:0009055	electron carrier activity	TAS	2813353
GO:0016491	oxidoreductase activity	IDA	16401082
GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	IMP	2813353

CYP1A2 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for CYP1A2:

Decreased nuclei size in G2M

Animal Models:
Mouse knock-outs for CYP1A2: Cyp1a2^tm1Dwn Cyp1a2^tm1Gonz Cyp1a2/Cyp1a1^{Cyp1a2/tm2Dwn} Cyp1a2/Cyp1a1^{Cyp1a2/tm1.1Bra}
11 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Cyp1a2):

behavior/neurological	cardiovascular system	endocrine/exocrine gland	hematopoietic system	homeostasis/metabolism
immune system	liver/biliary system	mortality/aging	no phenotypic analysis	respiratory system
tumorigenesis

CYP1A2 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/28 super-pathways (see all 28) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Tamoxifen metabolism

Tamoxifen metabolism	1.00	Estradiol metabolism	0.52
Tamoxifen Pathway, Pharmacokinetics	0.68	Benzodiazepine Pathway, Pharmacokinetics	0.30
Estradiol metabolism	0.52

Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)

Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)	1.00	Benzo[a]pyrene metabolism	0.33
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)	0.55	Benzo[a]pyrene metabolism	0.33
Warfarin Pathway, Pharmacokinetics	0.45

Estrone metabolism

	Estrone metabolism	1.00			Androstenedione and testosterone biosynthesis and metabolism p.1	0.57
	Estrone metabolism	1.00			Androstenedione and testosterone biosynthesis and metabolism p.1	0.57

Acetaminophen Pathway, Pharmacokinetics

	Pathway_PA165986194 -need delete	1.00			Acetaminophen metabolism	0.43
	Acetaminophen Pathway, Pharmacokinetics	1.00			Acetaminophen metabolism	0.43

Cytochrome P450 - arranged by substrate type

	Cytochrome P450 - arranged by substrate type	1.00			cytochrome P450	0.73
	Phase 1 - Functionalization of compounds	0.74

Pathway sources
See GeneCards unified pathways
Show all pathways

5/9 EMD Millipore Pathways for CYP1A2 (see all 9)

	Androstenedione and testosterone biosynthesis and metabolism p.1
	Estradiol metabolism
	Naphthalene metabolism
	Estrone metabolism
	Selected targets of HNF1

5/8 GeneGo (Thomson Reuters) Pathways for CYP1A2 (see all 8)

	Estradiol metabolism
	Retinol metabolism
	Naphthalene metabolism
	2-Naphthylamine and 2-Nitronaphtalene metabolism
	Estrone metabolism

5/11 BioSystems Pathways for CYP1A2 (see all 11)

	Aflatoxin B1 metabolism
	cytochrome P450
	Nuclear receptors in lipid metabolism and toxicity
	Arylamine metabolism
	Estrogen metabolism

5/12 Reactome Pathways for CYP1A2 (see all 12)

	Cytochrome P450 - arranged by substrate type
	Xenobiotics
	Metabolism
	Arachidonic acid metabolism
	Methylation

5/16 PharmGKB Pathways for CYP1A2 (see all 16)

	Acetaminophen Pathway, Pharmacokinetics
	Benzodiazepine Pathway, Pharmacokinetics
	Caffeine Pathway, Pharmacokinetics
	Carbamazepine Pathway, Pharmacokinetics
	Clomipramine Pathway, Pharmacokinetics

5/7 Kegg Pathways (Kegg details for CYP1A2) (see all 7):

	Caffeine metabolism
	Tryptophan metabolism
	Linoleic acid metabolism
	Retinol metabolism
	Metabolism of xenobiotics by cytochrome P450

CYP1A2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CYP1A2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/96 Interacting proteins for CYP1A2 (P05177³ ENSP00000342007⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 96)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
POR	P16435³	I2D: score=2
ADAMTSL4	Q6UY14³	I2D: score=1
AP2B1	P63010³	I2D: score=1
BEGAIN	Q9BUH8³	I2D: score=1
CHIC2	Q9UKJ5³	I2D: score=1

About this table

Gene Ontology (GO): 5/28 biological process terms (GO ID links to tree view) (see all 28): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006706	steroid catabolic process	IMP	18356043
GO:0006725	cellular aromatic compound metabolic process	--	--
GO:0006778	porphyrin-containing compound metabolic process	IEA	--
GO:0006805	xenobiotic metabolic process	TAS	--
GO:0006950	response to stress	IEA	--

CYP1A2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CYP1A2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CYP1A2

10/69 HMDB Compounds for CYP1A2 (see all 69) About this table

Compound	Synonyms	CAS #	PubMed Ids
Melatonin	5-Methoxy-N-acetyltryptamine (see all 23)	73-31-4	19919601
1,7-Dimethyluric acid		--	--
1-Methylxanthine		--	--
10-HETE	10-hydroxyeicosa-all-cis-5,8,11,14-tetraenoate (see all 2)	167697-52-1	--
11,12,15-THETA	11,12,15-Trihydroxyicosatrienoic acid (see all 5)	--	--
11,12-Epoxyeicosatrienoic acid	10-(3-(2-octenyl)oxiranyl)-5,8-Decadienoic acid (see all 15)	81276-02-0	--
11,14,15-THETA	(5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoic acid (see all 8)	--	--
11H-14,15-EETA	14,15-Ep-11-HETrE (see all 11)	219535-29-2	--
11beta-Hydroxytestosterone	11beta,17beta-dihydroxyandrost-4-en-3-one	1816-85-9	--
12,13-EpOME	Vernolic acid (see all 12)	--	--

10/237 DrugBank Compounds for CYP1A2 (see all 237) About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Fluvoxamine	Fluvoxamina [INN-Spanish] (see all 4)	54739-18-3	enzyme	substrate inhibitor	8846619 10774624 16910628 15664751 8968657 9868741 19934256
Clozapine	--	5786-21-0	enzyme	substrate inhibitor	8846619 9840430 19934256 10976659 19515014 19754423
Propranolol	Dl-Propranolol Hydrochloride (see all 7)	525-66-6	enzyme	substrate inhibitor	7895609 7640150 8846619 19934256 10976659 19754423
Erlotinib	--	183321-74-6	enzyme	substrate	17575239 16890575 16609030 16166415 19733976
Amitriptyline	Amitriprolidine (see all 7)	50-48-6	enzyme	substrate	11259560 18359012 19934256 19515014
Caffeine	Cafeina (see all 7)	58-08-2	enzyme	substrate inhibitor	8846619 19934256 9492382 19515014
Duloxetine	Duloxetine HCl (see all 2)	136434-34-9	enzyme	substrate	18307373 21366359 17121211 19480470
Frovatriptan	--	158747-02-5	enzyme	substrate	11735616 12028322 19934256 12028321
Melatonin	MEL (see all 4)	73-31-4	enzyme	substrate inhibitor	19919601 15616152 19934256 15626586
Nortriptyline	--	72-69-5	enzyme	substrate	18359012 19934256 9193876 19515014

10/154 Novoseek chemical compound relationships for CYP1A2 gene (see all 154) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
furafylline	92.6	50	9585555 (3), 8261428 (2), 2378786 (2), 8093105 (2) (see all 29)
phenacetin	90.5	79	10189256 (5), 8474022 (3), 15766918 (3), 9195021 (2) (see all 44)
ethoxyresorufin	90.2	84	15766918 (4), 8093105 (3), 10460801 (2), 10224324 (1) (see all 52)
alpha-naphthoflavone	89.9	44	15766918 (2), 8723730 (1), 12758162 (1), 7895609 (1) (see all 32)
paraxanthine	88.6	40	1302044 (3), 16261361 (2), 8919637 (2), 15980104 (2) (see all 23)
1,7-dimethyluric acid	87.6	19	10197295 (2), 10027663 (1), 12189363 (1), 11393735 (1) (see all 13)
afmu	86.7	36	10027663 (1), 10197295 (1), 15025748 (1), 11596199 (1) (see all 15)
sulfaphenazole	85.4	12	8214760 (1), 11792676 (1), 17702393 (1), 9431831 (1) (see all 11)
chlorzoxazone	83.7	17	8968357 (1), 9744576 (1), 10421611 (1), 12818727 (1) (see all 17)
1-methylxanthine	83	30	10197295 (2), 10027663 (1), 12189363 (1), 11393735 (1) (see all 14)

5 PharmGKB related drug/compound annotations for CYP1A2 gene

Drug/compound	PharmGKB Annotation
antipsychotics	CA
caffeine	CA
fluvoxamine	DL
leflunomide	CA
olanzapine	CA DL

About this table

Search CenterWatch for drugs/clinical trials and news about CYP1A2 / CP1A2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CYP1A2 gene:

NM_000761.3

Unigene Cluster for CYP1A2:

Cytochrome P450, family 1, subfamily A, polypeptide 2

Hs.1361 [show with all ESTs]

Unigene Representative Sequence: M55053

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000343932(uc002ayr.1)

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CYP1A2

Additional cDNA sequence:

AF182274.1 BC067424.1 BC067425.1 BC067426.1 BC067427.1 BC067428.1 BC067429.1 M12078.1

M55053.1 Z00036.1

1 DOTS entry:

DT.101963399

24/27 AceView cDNA sequences (see all 27):

CF271968 CB115370 CF271973 BC067424 BC067425 BC067426 BC067428 Z00036

CF271975 T62116 CK130237 CK130236 AF182274 BC067427 BC067429 CF271974

CF271972 NM_000761 T62882 CF271976 M12078 CF271978 BU658511 M55053

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CYP1A2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

CYP1A2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Liver

Perivenous Hepatocytes

Liver

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See CYP1A2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CYP1A2

SOURCE GeneReport for Unigene cluster: Hs.1361

UniProtKB/Swiss-Prot: CP1A2_HUMAN, P05177

Tissue specificity: Liver

SABiosciences Expression via Pathway-Focused PCR Arrays including CYP1A2 (see all 6):

Cancer Drug Resistance in human mouse rat

Hepatotoxicity in human mouse rat

Drug Metabolism: Phase I Enzymes in human mouse rat

Cellular Stress Responses in human mouse rat

Molecular Toxicology PathwayFinder 384HT in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CYP1A2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CYP1A2
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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYP1A2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for CYP1A2 gene from 6/21 species (see all 21) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	F1P054_CHICK⁶	cytochrome P450 1A4	55(a)	1 → many	10(1822785-1826206)
lizard (Anolis carolinensis)	Reptilia	-- -- (see all 3)	--	58(a) 55(a) (see all 3)	many ↔ many many ↔ many (see all 3)	GL343721.1(52577-61909) AAWZ02038633(3410-8451)
zebrafish (Danio rerio)	Actinopterygii	cyp1a⁶	cytochrome P450, family 1, subfamily A	53(a)	1 → many	18(4974676-4985566)
fruit fly (Drosophila melanogaster)	Insecta	Cyp307a1³	cytochrome P450	26(a)		64D5 --
thale cress (Arabidopsis thaliana)	eudicotyledons	CYP703A2¹	cytochrome P450, family 703, subfamily A, polypeptide more	41.56(n) 30.75(a)		839470 NM_100010.3 NP_171635.1
rice (Oryza sativa)	Liliopsida	Os08g0131100¹	hypothetical protein	44.56(n) 30.53(a)		4344594 NM_001067462.1 NP_001060927.1

ENSEMBL Gene Tree for CYP1A2 (if available)
TreeFam Gene Tree for CYP1A2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CYP1A2 gene

CYP1B1² CYP17A1² CYP1A1² CYP2G1P² ENSG00000198251² CYP21A2²

18/25 SIMAP similar genes for CYP1A2 using alignment to 2 protein entries: CP1A2_HUMAN (see all proteins) (see all similar genes):

CYP1A1 CYP1B1 CYP17A1 CYP2U1 CYP2A6 CYP2G1P

CYP2D6 CYP2A13 CYP2A7 CYP2B6 CYP2J2 DKFZp686I24235

CYP2F1 CYP2A6V2 CYP2B7 CYP2R1 CYP2C18 CYP2C19

CYP1A2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

UniProtKB/Swiss-Prot: CP1A2_HUMAN, P05177

Polymorphism: The CYP1A2*1F allele which is quite common (40 to 50%) is due to a substitution of a base in the

non-coding region of the CYP1A2 gene and has the effect of decreasing the enzyme inducibility. Individuals who are

homozygous for the CYP1A2*1F allele are 'slow' caffeine metabolizers. Thus for these individual increased intake of

caffeine seems to be associated with a concomitant increase in the risk of non-fatal myocardial infraction (MI)

SNP ID	Valid	Clinical significance	Chr 15 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs2069522^1,2	C,F,H,	--	75039233(+)	`CTGTTC/TCTCTA`	1	--	us2k¹		34		NA NS EA MN WA CSA	3560
rs181692221^1,2		--	75039242(+)	`TATTGA/GATTCC`	1	--	us2k¹		0	--	--	--	--
rs34633714^1,2	F	--	75039246(+)	`GGATTC/TCCCAT`	1	--	us2k¹		5		MN	400
rs12592480^1,2	C,F,H,	--	75039272(+)	`TCTTCA/CCAGGT`	1	--	us2k¹		17		NS EA NA MN	1456
rs35590132^1,2	F	--	75039303(+)	`TTTCAG/AGAATA`	1	--	us2k¹		5		MN	400
rs72556503^1,2	F,	--	75039347(+)	`CTCACA/TTCCAT`	1	--	us2k¹		5		MN	396
rs35694136^1,2	C,F,	--	75039613(+)	`GCACAT/-GAACC`	1	--	us2k¹		8		MN NA CSA	402
rs185379004^1,2		--	75039658(+)	`AAAAAA/GAAAAA`	1	--	us2k¹		0	--	--	--	--
rs191321504^1,2		--	75039726(+)	`TAGATA/CTGACT`	1	--	us2k¹		0	--	--	--	--
rs56661147^1,2		--	75039768(+)	`GTACAA/GCAAAC`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for CYP1A2 (75041184 - 75048941 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for CYP1A2
1 Inversion: 37170
Human Gene Mutation Database (HGMD): CYP1A2

Locus Specific Mutation Databases (LSDB): CYP1A2

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CYP1A2

DNA2.0 Custom Variant and Variant Library Synthesis for CYP1A2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CYP1A2 for disorders           About GeneDecksing

OMIM gene information: 124060    OMIM disorders: --

20/107 diseases for CYP1A2 (see all 107):    About MalaCards

porphyria cutanea tarda attention deficit hyperactivity disorder antley-bixler syndrome neural tube defect

testicular germ cell tumor malignant pleural mesothelioma cholesterol non-hodgkin lymphoma

autoimmune polyendocrine syndrome tardive dyskinesia familial adenomatous polyposis testicular germ cell cancer

major depressive disorder germ cell tumor birth defects porphyria

4 diseases from the University of Copenhagen DISEASES database for CYP1A2:

Porphyria cutanea tarda Schizophrenia Liver disease Hepatocellular carcinoma

10/57 Novoseek disease relationships for CYP1A2 gene (see all 57) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
chemical carcinogenesis	54.6	4	1486867 (1), 12520071 (1), 11370663 (1), 11943609 (1)
porphyria cutanea tarda	40.9	4	12566081 (1), 11153915 (1), 15202857 (1)
hepatitis autoimmune	23	2	8905121 (1), 9241657 (1)
cancer	22.7	19	10493258 (2), 10473105 (1), 16402077 (1), 7881341 (1) (see all 17)
apeced	19.1	1	14764761 (1)
liver diseases	18.4	3	12569554 (1), 9453493 (1)
breast cancer	15.9	31	17507615 (4), 15217502 (3), 16538170 (3), 19415745 (2) (see all 13)
schizophrenia	13.2	28	15564895 (3), 16775389 (3), 10889552 (3), 16490169 (2) (see all 13)
chronic liver disease	11.1	3	16841221 (1), 8672739 (1), 19643819 (1)
colorectal cancer	10.2	16	12534642 (3), 16800822 (2), 11751443 (2), 17603900 (1) (see all 10)

Genetic Association Database (GAD): CYP1A2
Human Genome Epidemiology (HuGE) Navigator: CYP1A2 (273 documents)

Export disorders for CYP1A2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CYP1A2 gene, integrated from 9 sources (see all 1336):
(articles sorted by number of sources associating them with CYP1A2)

Utopia: connect your pdf to the dynamic
world of online information

Single nucleotide polymorphisms and haplotypes of CYP1A2 in a Japanese population. (PubMed id 15770072)^{1, 2, 4} Soyama A.... Sawada J. (2005)
The G-113A polymorphism in CYP1A2 affects the caffeine metabolic ratio in a Chinese population. (PubMed id 16153396)^{1, 4, 9} Chen X....He F. (2005)
Genetic association analysis of functional polymorphisms in the cytochrome P450 1A2 (CYP1A2) gene with tardive dyskinesia in Japanese patients with schizophrenia. (PubMed id 15564895)^{1, 4, 9} Matsumoto C....Nakamura J. (2004)
Inducibility of CYP1A2 by omeprazole in vivo related to the genetic polymorphism of CYP1A2. (PubMed id 12445035)^{1, 4, 9} Han X.M....Zhou H.H. (2002)
Ah receptor, CYP1A1, CYP1A2 and CYP1B1 gene polymorphisms are not involved in the risk of recurrent pregnancy loss. (PubMed id 15299091)^{1, 4, 9} Saijo Y....Kishi R. (2004)
Polymorphisms in the cytochrome P450 CYP1A2 gene (CYP1A2) in colorectal cancer patients and controls: allele frequencies, linkage disequilibrium and influence on caffeine metabolism. (PubMed id 12534642)^{1, 4, 9} Sachse C....Gooderham N.J. (2003)
The effect of the CYP1A2 *1F mutation on CYP1A2 inducibility in pregnant women. (PubMed id 12445029)^{1, 4, 9} Nordmark A....Rane A. (2002)
Treatment-resistance to clozapine in association with ultrarapid CYP1A2 activity and the C-->A polymorphism in intron 1 of the CYP1A2 gene: effect of grapefruit juice and low-dose fluvoxamine. (PubMed id 11763009)^{1, 4, 9} Ozdemir V....Roy R. (2001)
Toward the evaluation of function in genetic variability: characterizing human SNP frequencies and establishing BAC-transgenic mice carrying the human CYP1A1_CYP1A2 locus. (PubMed id 15643613)^{1, 2, 9} Jiang Z.... Nebert D.W. (2005)
Cytochrome P450 (CYP) 1A2, sulfotransferase (SULT) 1A1, and N-acetyltransferase (NAT) 2 polymorphisms and susceptibility to urothelial cancer. (PubMed id 14648207)^{1, 4, 9} Tsukino H....Katoh T. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 1544	HGNC: 2596	AceView: CYP1A2	Ensembl:ENSG00000140505	euGenes: HUgn1544
ECgene: CYP1A2	Kegg: 1544	H-InvDB: CYP1A2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CYP1A2	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for CYP1A2	Genetics and Cytogenetics in Oncology and Haematology
Cytochrome P450 Allele Nomenclature Committee	http://www.cypalleles.ki.se/cyp1a2.htm
NIEHS-SNPs	http://egp.gs.washington.edu/data/cyp1a2/

Intellectual Property for CYP1A2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for CYP1A2 gene:
Search GeneIP for patents involving CYP1A2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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cytochrome P450, family 1, subfamily A, polypeptide 2

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CYP1A2 Gene

cytochrome P450, family 1, subfamily A, polypeptide 2

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