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Aliases for CYP1A1 Gene

Aliases for CYP1A1 Gene

  • Cytochrome P450, Family 1, Subfamily A, Polypeptide 1 2 3
  • Cytochrome P450, Subfamily I (Aromatic Compound-Inducible), Polypeptide 1 2 3
  • Cytochrome P450 Form 6 3 4
  • Cytochrome P450-P1 3 4
  • Cytochrome P450-C 3 4
  • EC 1.14.14.1 4 63
  • CYPIA1 3 4
  • Cytochrome P1-450, Dioxin-Inducible 3
  • Flavoprotein-Linked Monooxygenase 3
  • Aryl Hydrocarbon Hydroxylase 3
  • Xenobiotic Monooxygenase 3
  • P1-450 3
  • P450-C 3
  • P450DX 3
  • AhRR 3
  • CYP1 3
  • CP11 3
  • AHH 3

External Ids for CYP1A1 Gene

Previous HGNC Symbols for CYP1A1 Gene

  • CYP1

Previous GeneCards Identifiers for CYP1A1 Gene

  • GC15M068848
  • GC15M068126
  • GC15M072587
  • GC15M072727
  • GC15M072798
  • GC15M075011
  • GC15M051809

Summaries for CYP1A1 Gene

Entrez Gene Summary for CYP1A1 Gene

  • This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15. [provided by RefSeq, Jul 2008]

GeneCards Summary for CYP1A1 Gene

CYP1A1 (Cytochrome P450, Family 1, Subfamily A, Polypeptide 1) is a Protein Coding gene. Diseases associated with CYP1A1 include ehrlich tumor carcinoma and pyridoxine deficiency. Among its related pathways are AhR pathway (WikiPathways) and Metabolism. GO annotations related to this gene include enzyme binding and iron ion binding. An important paralog of this gene is CYP21A2.

UniProtKB/Swiss-Prot for CYP1A1 Gene

  • Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics

Gene Wiki entry for CYP1A1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYP1A1 Gene

Genomics for CYP1A1 Gene

Regulatory Elements for CYP1A1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CYP1A1 Gene

Chromosome:
15
Start:
74,719,542 bp from pter
End:
74,725,610 bp from pter
Size:
6,069 bases
Orientation:
Minus strand

Genomic View for CYP1A1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CYP1A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYP1A1 Gene

Proteins for CYP1A1 Gene

  • Protein details for CYP1A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P04798-CP1A1_HUMAN
    Recommended name:
    Cytochrome P450 1A1
    Protein Accession:
    P04798
    Secondary Accessions:
    • A4F3V9
    • A4F3W0
    • Q53G18

    Protein attributes for CYP1A1 Gene

    Size:
    512 amino acids
    Molecular mass:
    58165 Da
    Cofactor:
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CYP1A1 Gene

    Alternative splice isoforms for CYP1A1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CYP1A1 Gene

Proteomics data for CYP1A1 Gene at MOPED

Post-translational modifications for CYP1A1 Gene

  • Glycosylation at Ser 67
  • Modification sites at PhosphoSitePlus

Antibody Products

Domains & Families for CYP1A1 Gene

Gene Families for CYP1A1 Gene

Graphical View of Domain Structure for InterPro Entry

P04798

UniProtKB/Swiss-Prot:

CP1A1_HUMAN :
  • Belongs to the cytochrome P450 family.
Family:
  • Belongs to the cytochrome P450 family.
genes like me logo Genes that share domains with CYP1A1: view

Function for CYP1A1 Gene

Molecular function for CYP1A1 Gene

GENATLAS Biochemistry:
cytochrome p450,family I (polycytic aromatic compound-inducible),member A1 (see CYP1@),associated with susceptibility to lung squamous cell carcinoma and to childhood acute lymphoblastic leukemia (in association with deletion of GSTM1)
UniProtKB/Swiss-Prot CatalyticActivity:
RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O
UniProtKB/Swiss-Prot Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics
UniProtKB/Swiss-Prot Induction:
By 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)

Enzyme Numbers (IUBMB) for CYP1A1 Gene

Gene Ontology (GO) - Molecular Function for CYP1A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004497 monooxygenase activity IBA --
GO:0005506 iron ion binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0008395 steroid hydroxylase activity IEA --
genes like me logo Genes that share ontologies with CYP1A1: view
genes like me logo Genes that share phenotypes with CYP1A1: view

Animal Models for CYP1A1 Gene

MGI Knock Outs for CYP1A1:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CYP1A1

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for CYP1A1 Gene

Localization for CYP1A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYP1A1 Gene

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CYP1A1 Gene COMPARTMENTS Subcellular localization image for CYP1A1 gene
Compartment Confidence
endoplasmic reticulum 5
nucleus 3
cytosol 2
mitochondrion 2
peroxisome 2
cytoskeleton 1
extracellular 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CYP1A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm --
GO:0005739 mitochondrion IEA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0043231 intracellular membrane-bounded organelle --
genes like me logo Genes that share ontologies with CYP1A1: view

Pathways & Interactions for CYP1A1 Gene

genes like me logo Genes that share pathways with CYP1A1: view

PCR Array Products

Gene Ontology (GO) - Biological Process for CYP1A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001666 response to hypoxia IEA --
GO:0001889 liver development --
GO:0006778 porphyrin-containing compound metabolic process IEA --
GO:0006805 xenobiotic metabolic process TAS --
GO:0007568 aging IEA --
genes like me logo Genes that share ontologies with CYP1A1: view

No data available for SIGNOR curated interactions for CYP1A1 Gene

Drugs & Compounds for CYP1A1 Gene

(172) Drugs for CYP1A1 Gene - From: NovoSeek, FDA Approved Drugs, DrugBank, HMDB, and PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Chlorzoxazone Approved Pharma Agonist, Activator, Enzyme, substrate 6
Clofibrate Approved Pharma Agonist, Enzyme, inducer 2
Daunorubicin Approved Pharma Enzyme, substrate 244
Dexamethasone Approved, Investigational Pharma Agonist, Enzyme, inhibitor, inducer 1806
Dronabinol Approved, Illicit Pharma Enzyme, substrate 110

(105) Additional Compounds for CYP1A1 Gene - From: NovoSeek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
11,12,15-THETA
  • 11,12,15-TriHETRE
  • 11,12,15-Trihydroxyicosatrienoate
  • 11,12,15-Trihydroxyicosatrienoic acid
  • 11,12,15S-Trihydroxy-5Z,8Z,13E-eicosatrienoate
  • 11,12,15S-Trihydroxy-5Z,8Z,13E-eicosatrienoic acid
11,12-Epoxyeicosatrienoic acid
  • (5Z,8Z,14Z)-11,12-Epoxyeicosa-5,8,14-trienoate
  • (5Z,8Z,14Z)-11,12-Epoxyeicosa-5,8,14-trienoic acid
  • (5Z,8Z,14Z)-11,12-Epoxyicosa-5,8,14-trienoate
  • (5Z,8Z,14Z)-11,12-Epoxyicosa-5,8,14-trienoic acid
  • 10-(3-(2-Octenyl)oxiranyl)-5,8-Decadienoate
81276-02-0
11,14,15-THETA
  • (5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoate
  • (5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoic acid
  • (5Z,8Z,12E)-11,14,15-Trihydroxyicosa-5,8,12-trienoate
  • (5Z,8Z,12E)-11,14,15-Trihydroxyicosa-5,8,12-trienoic acid
  • 11,14,15-Trihydroxy-5Z,8Z,12E-eicosatrienoate
11H-14,15-EETA
  • (5Z,8Z,12E)-14,15-Epoxy-11-hydroxyeicosa-5,8,12-trienoate
  • (5Z,8Z,12E)-14,15-Epoxy-11-hydroxyeicosa-5,8,12-trienoic acid
  • (5Z,8Z,12E)-14,15-Epoxy-11-hydroxyicosa-5,8,12-trienoate
  • (5Z,8Z,12E)-14,15-Epoxy-11-hydroxyicosa-5,8,12-trienoic acid
  • 11-Hydroxy-14,15-EETA
219535-29-2
12,13-EpOME
  • (+/-)-12(13)-epoxy-9Z-octadecenoate
  • (+/-)-12(13)-epoxy-9Z-octadecenoic acid
  • (9Z)-11-(3-pentyloxiran-2-yl)undec-9-enoate
  • (9Z)-11-(3-pentyloxiran-2-yl)undec-9-enoic acid
  • (9Z)-12,13-epoxyoctadecenoate
genes like me logo Genes that share compounds with CYP1A1: view

Transcripts for CYP1A1 Gene

Unigene Clusters for CYP1A1 Gene

Cytochrome P450, family 1, subfamily A, polypeptide 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CYP1A1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CYP1A1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
SP1:
SP2:

Relevant External Links for CYP1A1 Gene

GeneLoc Exon Structure for
CYP1A1
ECgene alternative splicing isoforms for
CYP1A1

Expression for CYP1A1 Gene

mRNA expression in normal human tissues for CYP1A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CYP1A1 Gene

This gene is overexpressed in Liver (x8.2), Lung (x5.5), Adipose - Subcutaneous (x5.0), and Skin - Sun Exposed (Lower leg) (x4.0).

Protein differential expression in normal tissues from HIPED for CYP1A1 Gene

This gene is overexpressed in Gallbladder (22.6), Liver (18.4), Plasma (12.0), Pancreatic juice (10.0), and Islet of Langerhans (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CYP1A1 Gene



SOURCE GeneReport for Unigene cluster for CYP1A1 Gene Hs.72912

mRNA Expression by UniProt/SwissProt for CYP1A1 Gene

P04798-CP1A1_HUMAN
Tissue specificity: Lung, lymphocytes and placenta
genes like me logo Genes that share expression patterns with CYP1A1: view

Protein tissue co-expression partners for CYP1A1 Gene

Primer Products

In Situ Assay Products

Orthologs for CYP1A1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CYP1A1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CYP1A1 35
  • 85.42 (n)
  • 81.18 (a)
CYP1A1 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CYP1A1 35
  • 84.65 (n)
  • 82.09 (a)
CYP1A1 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cyp1a1 35
  • 82.61 (n)
  • 80.39 (a)
Cyp1a1 16
Cyp1a1 36
  • 78 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LOC453744 35
  • 99.67 (n)
  • 99.8 (a)
CYP1A1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cyp1a1 35
  • 82.42 (n)
  • 79.61 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 72 (a)
ManyToMany
-- 36
  • 59 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 70 (a)
OneToMany
chicken
(Gallus gallus)
Aves CYP1A1 35
  • 67.06 (n)
  • 62.4 (a)
CYP1A1 36
  • 60 (a)
ManyToMany
CYP1A4 36
  • 58 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 55 (a)
ManyToMany
-- 36
  • 58 (a)
ManyToMany
-- 36
  • 60 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia cyp1a1 35
  • 65.14 (n)
  • 63.22 (a)
Str.2144 35
zebrafish
(Danio rerio)
Actinopterygii cyp1a 35
  • 60.88 (n)
  • 57.88 (a)
cyp1a1 35
cyp1a 36
  • 55 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Cyp18a1 37
  • 32 (a)
Cyp307a1 37
  • 28 (a)
spo 36
  • 24 (a)
ManyToMany
spok 36
  • 22 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons CYP93D1 35
  • 40.54 (n)
  • 28.05 (a)
rice
(Oryza sativa)
Liliopsida Os06g0613600 35
  • 45.38 (n)
  • 31.3 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 31 (a)
ManyToMany
-- 36
  • 21 (a)
ManyToMany
Species with no ortholog for CYP1A1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CYP1A1 Gene

ENSEMBL:
Gene Tree for CYP1A1 (if available)
TreeFam:
Gene Tree for CYP1A1 (if available)

Paralogs for CYP1A1 Gene

Paralogs for CYP1A1 Gene

Pseudogenes.org Pseudogenes for CYP1A1 Gene

genes like me logo Genes that share paralogs with CYP1A1: view

Variants for CYP1A1 Gene

Sequence variations from dbSNP and Humsavar for CYP1A1 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs1048943 - 74,720,644(-) AGACC(A/C/G/T)TTGCC reference, missense
rs1799814 - 74,720,646(-) TGAGA(A/C/T)CATTG missense, reference
rs1800031 -- 74,719,894(-) CCTTC(C/T)GGCCT utr-variant-3-prime
rs2229150 - 74,722,821(-) CCATC(C/T)GGCAG reference, missense
rs2278970 -- 74,720,640(+) AGCGG(A/C/G)CAAYG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for CYP1A1 Gene

Variant ID Type Subtype PubMed ID
nsv904379 CNV Loss 21882294
nsv904380 CNV Loss 21882294
nsv817698 CNV Gain 17921354
nsv833055 CNV Loss 17160897

Variation tolerance for CYP1A1 Gene

Residual Variation Intolerance Score: 96.25% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.23; 84.97% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CYP1A1 Gene

HapMap Linkage Disequilibrium report
CYP1A1
Human Gene Mutation Database (HGMD)
CYP1A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CYP1A1 Gene

Disorders for CYP1A1 Gene

MalaCards: The human disease database

(26) MalaCards diseases for CYP1A1 Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
ehrlich tumor carcinoma
  • ehrlich's tumor
pyridoxine deficiency
  • vitamin b6 deficiency
lung squamous cell carcinoma
  • epidermoid cell carcinoma of the lung
basal cell carcinoma, multiple
  • multiple basal cell carcinoma
oral cavity cancer
  • malignant tumor of the floor of the mouth
- elite association

Relevant External Links for CYP1A1

Genetic Association Database (GAD)
CYP1A1
Human Genome Epidemiology (HuGE) Navigator
CYP1A1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CYP1A1
genes like me logo Genes that share disorders with CYP1A1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CYP1A1 Gene

Publications for CYP1A1 Gene

  1. Chlorzoxazone metabolism by porcine cytochrome P450 enzymes and the effect of cytochrome b5. (PMID: 20164110) Wiercinska P. … Squires E.J. (Drug Metab. Dispos. 2010) 23 25 26 67
  2. Inhibition of procarcinogen-bioactivating human CYP1A1, CYP1A2 and CYP1B1 enzymes by melatonin. (PMID: 19919601) Chang T.K. … Yeung E.Y. (J. Pineal Res. 2010) 23 25 26 67
  3. Role of adrenoceptor-linked signaling pathways in the regulation of CYP1A1 gene expression. (PMID: 15627480) Konstandi M. … Lang M.A. (Biochem. Pharmacol. 2005) 23 25 26 67
  4. Induction of CYP1A1 by GABA receptor ligands. (PMID: 8954111) Sadar M.D. … Andersson T.B. (Biochem. Biophys. Res. Commun. 1996) 23 25 26 67
  5. The metabolism of amiodarone by various CYP isoenzymes of human and rat, and the inhibitory influence of ketoconazole. (PMID: 18445370) Elsherbiny M.E. … Brocks D.R. (J Pharm Pharm Sci 2008) 23 25 67

Products for CYP1A1 Gene

Sources for CYP1A1 Gene

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