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CYP1A1 Gene

protein-coding   GIFtS: 74
GCID: GC15M075011

Cytochrome P450, Family 1, Subfamily A, Polypeptide 1

(Previous names: cytochrome P450, subfamily I (aromatic compound-inducible),...)
(Previous symbol: CYP1)
  See CYP1A1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cytochrome P450, Family 1, Subfamily A, Polypeptide 11 2     CP112
CYP11 2 5     P1-4502
Cytochrome P450, Subfamily I (Aromatic Compound-Inducible), Polypeptide 11 2     P450-C2
Cytochrome P450 Form 62 3     P450DX2
Cytochrome P450-C2 3     Aryl Hydrocarbon Hydroxylase2
Cytochrome P450-P12 3     Cytochrome P1-450, Dioxin-Inducible2
CYPIA12 3     Cytochrome P450 1A12
EC 1.14.14.13 8     Flavoprotein-Linked Monooxygenase2
AHH2     Xenobiotic Monooxygenase2
AHRR2     

External Ids:    HGNC: 25951   Entrez Gene: 15432   Ensembl: ENSG000001404657   OMIM: 1083305   UniProtKB: P047983   

Export aliases for CYP1A1 gene to outside databases

Previous GC identifers: GC15M068848 GC15M068126 GC15M072587 GC15M072727 GC15M072798 GC15M051809


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CYP1A1 Gene:
This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins
are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol,
steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by
some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous
substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has
been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from
CYP1A1 on chromosome 15. (provided by RefSeq, Jul 2008)

GeneCards Summary for CYP1A1 Gene:
CYP1A1 (cytochrome P450, family 1, subfamily A, polypeptide 1) is a protein-coding gene. Diseases associated with CYP1A1 include basal cell carcinoma, multiple, and oral cancer. GO annotations related to this gene include iron ion binding and enzyme binding. An important paralog of this gene is CYP1A2.

UniProtKB/Swiss-Prot: CP1A1_HUMAN, P04798
Function: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is
involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated
compounds, including steroids, fatty acids, and xenobiotics

Gene Wiki entry for CYP1A1 (Cytochrome P450, family 1, member A1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000015.9  NT_010194.18  NC_018926.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CYP1A1 gene promoter:
         GR   C/EBPbeta   p53   SREBP-1c   Bach2   SREBP-1b   HNF-4alpha1   MZF-1   SREBP-1a   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): CYP1A1 promoter sequence
   Search Chromatin IP Primers for CYP1A1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CYP1A1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q24.1   Ensembl cytogenetic band:  15q24.1   HGNC cytogenetic band: 15q24.1

CYP1A1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CYP1A1 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M075011:  view genomic region     (about GC identifiers)

Start:
75,011,883 bp from pter      End:
75,017,951 bp from pter
Size:
6,069 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CP1A1_HUMAN, P04798 (See protein sequence)
Recommended Name: Cytochrome P450 1A1  
Size: 512 amino acids; 58165 Da
Cofactor: Heme group
1 PDB 3D structure from and Proteopedia for CYP1A1:
4I8V (3D)    
Secondary accessions: A4F3V9 A4F3W0 Q53G18
Alternative splicing: 3 isoforms:  P04798-1   P04798-2   P04798-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CYP1A1: NX_P04798

Explore proteomics data for CYP1A1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for CYP1A1 (P04798) (see all 25)
     FSIASDP  PILRYLP  NQWQINH  ELDTVIG 


    See CYP1A1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000490.1  
    ENSEMBL proteins: 
     ENSP00000369050   ENSP00000456585   ENSP00000378489   ENSP00000455340   ENSP00000457668  
     ENSP00000455051   ENSP00000455846   ENSP00000378488  
    Reactome Protein details: P04798

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CYP: Cytochrome P450s

    IUPHAR Guide to PHARMACOLOGY protein family classification: CYP1A1
    CYP1 family

    4 InterPro protein domains:
     IPR001128 Cyt_P450
     IPR017972 Cyt_P450_CS
     IPR002401 Cyt_P450_E_grp-I
     IPR008066 Cyt_P450_E_grp-I_CYP1

    Graphical View of Domain Structure for InterPro Entry P04798

    ProtoNet protein and cluster: P04798

    2 Blocks protein domains:
    IPB002401 E-class P450 group I signature
    IPB008066 CYP1A P450 family signature


    UniProtKB/Swiss-Prot: CP1A1_HUMAN, P04798
    Similarity: Belongs to the cytochrome P450 family


    Find genes that share domains with CYP1A1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CP1A1_HUMAN, P04798
    Function: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is
    involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated
    compounds, including steroids, fatty acids, and xenobiotics
    Catalytic activity: RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O
    Induction: By 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)

         Genatlas biochemistry entry for CYP1A1:
    cytochrome p450,family I (polycytic aromatic compound-inducible),member A1 (see CYP1@),associated with
    susceptibility to lung squamous cell carcinoma and to childhood acute lymphoblastic leukemia (in association with
    deletion of GSTM1)

         Enzyme Number (IUBMB): EC 1.14.14.11 2

         Gene Ontology (GO): Selected molecular function terms (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004497monooxygenase activity ----
    GO:0005506iron ion binding IEA--
    GO:0005515protein binding ----
    GO:0008395steroid hydroxylase activity IEA--
         
    Find genes that share ontologies with CYP1A1           About GenesLikeMe


    Phenotypes:
         9 MGI mutant phenotypes (inferred from 7 alleles(MGI details for Cyp1a1):
     cardiovascular system  growth/size/body  hematopoietic system  homeostasis/metabolism  immune system 
     liver/biliary system  mortality/aging  no phenotypic analysis  normal 

    Find genes that share phenotypes with CYP1A1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for CYP1A1: Cyp1a1tm1.1Dwn Cyp1a2/Cyp1a1Cyp1a2/tm2Dwn Cyp1a2/Cyp1a1Cyp1a2/tm1.1Bra

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    SwitchGear 3'UTR luciferase reporter plasmidCYP1A1 3' UTR sequence
    Inhib. RNA
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CYP1A1

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYP1A1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CP1A1_HUMAN, P04798: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral
    membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    nucleus3
    cytosol2
    mitochondrion2
    cytoskeleton1
    extracellular1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005739mitochondrion IEA--
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0043231intracellular membrane-bounded organelle ----

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    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CYP1A1 About   (see all 18)  
    See pathways by source

    SuperPathContained pathways About
    1Biological oxidations
    Biological oxidations0.56
    Tamoxifen metabolism0.00
    metapathway biotransformation0.42
    Estradiol metabolism0.00
    Benzo(a)pyrene metabolism0.00
    Acetaminophen metabolism0.00
    2Cytochrome P450 - arranged by substrate type
    Cytochrome P450 - arranged by substrate type0.75
    Xenobiotics0.00
    Phase 1 - Functionalization of compounds0.75
    Fatty Acid Omega Oxidation0.00
    cytochrome P4500.74
    3Arachidonic acid metabolism
    Arachidonic acid metabolism0.40
    Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)0.00
    Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)0.00
    Amodiaquine Pathway, Pharmacokinetics0.00
    4Chemical carcinogenesis
    Chemical carcinogenesis0.71
    Retinol metabolism0.35
    Metabolism of xenobiotics by cytochrome P4500.71
    Benzo a pyrene metabolism0.00
    5Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    Metabolic pathways0.38


    Find genes that share SuperPaths with CYP1A1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for CYP1A1
        AHR Pathway

    Selected GeneGo (Thomson Reuters) Pathways for CYP1A1 (see all 7)
        Estradiol metabolism
    Retinol metabolism
    Naphthalene metabolism
    2-Naphthylamine and 2-Nitronaphtalene metabolism
    Benzo[a]pyrene metabolism

    Selected BioSystems Pathways for CYP1A1 (see all 9)
        cytochrome P450
    Oxidative Stress
    Tamoxifen metabolism
    Benzo(a)pyrene metabolism
    Estrogen metabolism


    4 Reactome Pathways for CYP1A1
        Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)
    Xenobiotics
    PPARA activates gene expression
    Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)

    Selected PharmGKB Pathways for CYP1A1 (see all 6)
        Acetaminophen Pathway, Pharmacokinetics
    Amodiaquine Pathway, Pharmacokinetics
    Erlotinib Pathway, Pharmacokinetics
    Estrogen Metabolism Pathway
    Gefitinib Pathway, Pharmacokinetics

    Selected Kegg Pathways  (Kegg details for CYP1A1) (see all 7):
        Steroid hormone biosynthesis
    Tryptophan metabolism
    Retinol metabolism
    Metabolism of xenobiotics by cytochrome P450
    Metabolic pathways

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CYP1A1 (see all 6): 
              Estrogen Receptor Signaling in human mouse rat
              Cancer Drug Resistance in human mouse rat
              Drug Metabolism: Phase I Enzymes in human mouse rat
              Cellular Stress Responses in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CYP1A1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CYP1A1 (P047983 ENSP000003690504) via UniProtKB, MINT, STRING, and/or I2D (see all 92)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CYB5AP001673, ENSP000003416254I2D: score=1 STRING: ENSP00000341625
    HSPA4P349323, ENSP000003029614I2D: score=1 STRING: ENSP00000302961
    HSP90AA1P079003, ENSP000003351534I2D: score=1 STRING: ENSP00000335153
    AKR1C1ENSP000003702544STRING: ENSP00000370254
    AKR1C3ENSP000003699274STRING: ENSP00000369927
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 47):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001666response to hypoxia IEA--
    GO:0001889liver development ----
    GO:0006778porphyrin-containing compound metabolic process IEA--
    GO:0006805xenobiotic metabolic process TAS--
    GO:0007568aging IEA--

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    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CYP1A1 (CP1A1)

    Selected HMDB Compounds for CYP1A1 (see all 54)    About this table
    CompoundSynonyms CAS #PubMed Ids
    Melatonin5-Methoxy-N-acetyltryptamine (see all 23)73-31-419919601
    10-HETE10-hydroxyeicosa-all-cis-5,8,11,14-tetraenoate (see all 2)167697-52-1--
    11,12,15-THETA11,12,15-Trihydroxyicosatrienoic acid (see all 5)----
    11,12-Epoxyeicosatrienoic acid10-(3-(2-octenyl)oxiranyl)-5,8-Decadienoic acid (see all 15)81276-02-0--
    11,14,15-THETA(5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoic acid (see all 8)----
    11H-14,15-EETA14,15-Ep-11-HETrE (see all 11)219535-29-2--
    11beta-Hydroxytestosterone11beta,17beta-dihydroxyandrost-4-en-3-one 1816-85-9--
    12,13-EpOMEVernolic acid (see all 12)----
    13-HETE13-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoate (see all 2)151910-72-4--
    14,15-Epoxy-5,8,11-eicosatrienoic acid(5Z,8Z,11Z)-14,15-Epoxyicosa-5.8.11-trienoic acid (see all 11)81276-03-1--

    Selected DrugBank Compounds for CYP1A1 (see all 90)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    ErlotinibCP358774 (see all 2)183321-74-6enzymesubstrate17575239 16166415 19733976
    MelatoninMEL (see all 4)73-31-4enzymesubstrate inhibitor19919601 15616152 19934256
    TamoxifenICI-46474 (see all 3)10540-29-1enzymesubstrate12124303 19934256 19515014
    AmiodaroneAmiodarona [INN-Spanish] (see all 5)1951-25-3enzymesubstrate18445370 19934256
    AmlodipineAmlodipine Benzenesulfonate (see all 6)88150-42-9enzymeinhibitor10805063 19934256
    Benzyl alcohol(Hydroxymethyl)benzene (see all 10)100-51-6enzyme--9065730 9726784
    ChlorzoxazoneChloroxazone (see all 3)95-25-0enzymesubstrate15231049 20164110
    Cinnarizine-- 298-57-7enzymesubstrate19934256 19515014
    Dasatinib-- 302962-49-8enzymesubstrate18556438 19733976
    Ellagic Acid-- 476-66-4enzymeinhibitor inducer8024593 19469472

    Selected Novoseek inferred chemical compound relationships for CYP1A1 gene (see all 140)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tcdd 94 698 8396892 (9), 15630080 (7), 11728381 (6), 9931287 (6) (see all 99)
    ethoxyresorufin 91.1 84 17959138 (4), 8093105 (3), 11599655 (2), 8396892 (1) (see all 67)
    benzo(a)pyrene 89.7 376 18372000 (6), 19330882 (6), 16280210 (6), 10503953 (6) (see all 99)
    alpha-naphthoflavone 88.1 64 1329656 (4), 12628305 (2), 2115161 (2), 1315629 (1) (see all 38)
    3-methylcholanthrene 86.4 193 12941938 (7), 16137816 (4), 17276403 (3), 9465551 (3) (see all 64)
    hydrocarbons 85.2 131 8954573 (2), 17630984 (2), 19362136 (2), 8353849 (2) (see all 99)
    mspi 84.8 71 1284589 (4), 8706015 (3), 8877059 (3), 8983277 (2) (see all 51)
    beta-naphthoflavone 82.9 79 11076701 (3), 12147246 (3), 18502397 (3), 19470599 (3) (see all 36)
    4-methoxyestradiol 79.6 1 10403516 (1)
    benz(a)anthracene 78.8 30 1700499 (4), 8920757 (2), 1358564 (2), 1654865 (2) (see all 14)

    6 PharmGKB related drug/compound annotations for CYP1A1 gene    About this table
    Drug/compound PharmGKB Annotation
    capecitabineCA  
    dexlansoprazole
    docetaxelCA  
    drospirenone
    ethinyl estradiol
    tiotropium



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    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CYP1A1 gene: 
    NM_000499.3  

    Unigene Cluster for CYP1A1:

    Cytochrome P450, family 1, subfamily A, polypeptide 1
    Hs.72912  [show with all ESTs]
    Unigene Representative Sequence: NM_000499
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000379727(uc002ayq.4 uc010bjy.3) ENST00000567032 ENST00000395049
    ENST00000562201 ENST00000564596(uc010bjz.1) ENST00000569630 ENST00000566503
    ENST00000395048(uc002ayp.4 uc010bju.3 uc010bjv.3 uc010bjw.3 uc010bjx.3)

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    GenScript: all cDNA clones in your preferred vector: CYP1A1 (NM_000499)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CYP1A1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CYP1A1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CYP1A1
    OriGene qSTAR qPCR primer pairs in human, mouse for CYP1A1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CYP1A1
      QuantiTect SYBR Green Assays in human, mouse, rat CYP1A1
      QuantiFast Probe-based Assays in human, mouse, rat CYP1A1

    Additional mRNA sequence: 

    AK223108.1 AK223113.1 AK310810.1 AK313880.1 AM233517.1 AM233518.1 AM233519.1 AM233520.1 
    AM236046.1 AM236047.1 AY310359.1 AY871801.1 BC023019.1 K03191.1 M12079.1 

    2 DOTS entries:

    DT.310017  DT.100744671 

    Selected AceView cDNA sequences (see all 52):

    AI417887 BU620769 BC023019 AL600919 AV656441 NM_000499 BQ878741 AW451941 
    AL600881 CA423835 AL600770 AW949660 BQ005861 CB267342 CA439920 BU941041 
    CB163693 AH007293 CB265483 AA418907 BP353358 CA426401 AL598760 BU182605 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for CYP1A1    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
    SP1:                                                
    SP2:                                                


    ECgene alternative splicing isoforms for CYP1A1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CYP1A1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTGCATAAG
    CYP1A1 Expression
    About this image


    CYP1A1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Liver (Hepatobiliary System)
             Perivenous Hepatocytes Liver Lobule
     
     Adipose (Muscoskeletal System)    fully expand to see all 2 entries
             Interscapular Brown Adipose Depot
             HyStem+BMP4-induced 7SMOO32 cells
     
     Lung (Respiratory System)
             Basal Cells Respiratory Bronchioles
     
     Placenta (Extraembryonic Tissues)
             Syncytiotrophoblast-like cells
    CYP1A1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CYP1A1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.72912

    UniProtKB/Swiss-Prot: CP1A1_HUMAN, P04798
    Tissue specificity: Lung, lymphocytes and placenta

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CYP1A1 (see all 6): 
              Estrogen Receptor Signaling in human mouse rat
              Cancer Drug Resistance in human mouse rat
              Drug Metabolism: Phase I Enzymes in human mouse rat
              Cellular Stress Responses in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CYP1A1
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    QuantiFast Probe-based Assays in human, mouse, rat CYP1A1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYP1A1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CYP1A1 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cyp1a11 , 5 cytochrome P450, family 1, subfamily a, polypeptide more1, 5 82.61(n)1
    80.39(a)1
      9 (31.34 cM)5
    130761  NM_001136059.21  NP_001129531.11 
     576976135 
    chicken
    (Gallus gallus)
    Aves CYP1A11 cytochrome P450, family 1, subfamily A, polypeptide more 67.06(n)
    62.4(a)
      396051  NM_205146.2  NP_990477.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 3)
    Uncharacterized protein
    (see all 3)
    60(a)
    58(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    GL343721.1(50982-63103)
    GL343721.1(108802-116982)
    African clawed frog
    (Xenopus laevis)
    Amphibia AB022087.12   -- 71.3(n)    AB022087.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cyp1a12 cytochrome P450, subfamily I, polypeptide 1 74.16(n)   140634  AB078927.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Cyp18a13 steroid biosynthesis cytochrome P450 32(a)
    (best of 2)
      17D1   --
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons CYP93D11 CYP93D1 40.54(n)
    28.05(a)
      830580  NM_120772.1  NP_196307.1 
    rice
    (Oryza sativa)
    Liliopsida Os06g06136001 Os06g0613600 45.38(n)
    31.3(a)
      4341526  NM_001064607.1  NP_001058072.1 


    ENSEMBL Gene Tree for CYP1A1 (if available)
    TreeFam Gene Tree for CYP1A1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CYP1A1 gene
    CYP1A22  CYP1B12  CYP17A12  CYP21A22  
    Selected SIMAP similar genes for CYP1A1 using alignment to 8 protein entries:     CP1A1_HUMAN (see all proteins) (see all similar genes):
    CYP1A2    CYP1B1    CYP4V2    CYP2U1    DKFZp686I24235    CYP2D6
    CYP2S1    CYP2A13    CYP2A6    CYP2A7    CYP21A2    CYP2F1
    CYP2R1    CYP2C8    CYP2J2    CYP2B7    CYP2A6V2    CYP2G1P

    Find genes that share paralogs with CYP1A1           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for CYP1A1
    PGOHUM00000236640


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CYP1A1 (see all 294)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1494232661,2
    --55062351(+) AGGGCA/GTAAGT 1 -- ds50010--------
    rs456271341,2
    C,F--55062527(-) CGCAGG/CCACAC 1 -- ds50015Minor allele frequency- C:0.01NS 176
    rs798120151,2
    F--55062576(+) GAGCCT/CGGAGG 1 -- ds50011Minor allele frequency- C:0.39PA 802
    rs46469031,2
    C,F,A,H--55062577(-) CCTCCA/C/TGGGCT 1 -- ds500117NA MN NS WA CSA EA 934
    rs1397748601,2
    --55062715(+) TGCTAC/TCTCCT 1 -- ds50010--------
    rs1889132831,2
    C--55062779(+) TTAGAC/GGAGTG 1 -- ds50010--------
    rs1817168151,2
    --55062780(+) TAGACA/GAGTGA 1 -- ds50010--------
    rs24723071,2
    C,H--55062791(+) TGAATC/TATTTA 1 -- ds500111Minor allele frequency- T:0.00NS EA NA MN 812
    rs1853831341,2
    --55062910(+) ATTAAA/CTCAAT 1 -- ut310--------
    rs178610841,2
    C,F--55062955(+) ATGCAG/TGCTAG 1 -- ut3111Minor allele frequency- T:0.06MN NS WA 714

    HapMap Linkage Disequilibrium report for CYP1A1 (75011883 - 75017951 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for CYP1A1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv904380CNV Loss21882294
    nsv904379CNV Loss21882294
    nsv833055CNV Loss17160897
    nsv817698CNV Gain17921354

    The Human Cytochrome P450 Allele Nomenclature Database: CYP1A1 
    Human Gene Mutation Database (HGMD): CYP1A1
    Locus Specific Mutation Databases (LSDB): CYP1A1

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CYP1A1
    DNA2.0 Custom Variant and Variant Library Synthesis for CYP1A1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 108330    OMIM disorders: --

    11 diseases for CYP1A1:    
    About MalaCards
    basal cell carcinoma, multiple    oral cancer    cardia cancer    basal cell carcinoma
    leukoplakia    barrett's esophagus    endometriosis    lung cancer
    colorectal cancer    prostate cancer    breast cancer

    4 diseases from the University of Copenhagen DISEASES database for CYP1A1:
    Lung cancer     Hepatocellular carcinoma     Breast cancer     Carcinoma

    Find genes that share disorders with CYP1A1           About GenesLikeMe

    93 Novoseek inferred disease relationships for CYP1A1 gene (see top 10)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ahh inducibility 87.7 42 8126925 (5), 8609043 (5), 9465551 (5), 9731718 (4) (see all 10)
    cancer lung 68.2 293 9894148 (6), 11778487 (6), 16228113 (6), 10491856 (5) (see all 99)
    genetic susceptibility 61.7 23 18304461 (2), 10698723 (1), 19472123 (1), 20054510 (1) (see all 18)
    chemical carcinogenesis 58 6 12628305 (1), 19573549 (1), 12520071 (1), 11370663 (1) (see all 6)
    cancer 57.9 119 8552885 (3), 15355884 (3), 15805301 (2), 16402077 (2) (see all 91)
    breast cancer 57.1 155 9485019 (6), 20088394 (5), 11408954 (5), 16807674 (4) (see all 79)
    environmental carcinogenesis 56.6 1 18463401 (1)
    oral cancer 46 35 19469619 (5), 17461521 (4), 19160101 (3), 9332761 (3) (see all 10)
    adenocarcinoma lung 43.3 14 17200336 (2), 12824892 (2), 15375499 (2), 11955671 (1) (see all 8)
    carcinoma squamous cell 43.2 41 11778487 (3), 10435155 (2), 7554077 (2), 10793329 (2) (see all 30)
    adult brain tumor 35.5 2 16598069 (1), 17372252 (1)
    endometrial cancer 33.5 23 18318428 (5), 9450474 (4), 9155064 (3), 17717632 (3) (see all 6)
    smoking habit 30.6 4 10753202 (1), 9488590 (1), 7515333 (1), 17512722 (1)
    lung carcinoma 26.4 16 11406420 (4), 2380990 (2), 9307183 (1), 11033235 (1) (see all 8)
    leukoplakia 26.1 4 12767509 (2), 19718946 (1), 10571654 (1)
    basal cell carcinoma, multiple 25.6 1 9077484 (1)
    lymphoblastic leukemia acute childhood 25.1 1 10029576 (1)
    endometriosis 24.1 21 12903034 (4), 15861041 (3), 12620480 (2), 18849443 (2) (see all 11)
    hepatocellular carcinoma 24 13 19064581 (2), 11710520 (1), 12147246 (1), 1657755 (1) (see all 10)
    prostate cancer 23.8 45 14743400 (4), 18304461 (3), 16466991 (3), 18647550 (3) (see all 21)
    breast carcinoma 23.1 24 15856430 (4), 2029891 (3), 18558727 (1), 12655030 (1) (see all 12)
    adenocarcinoma 22.9 15 7554077 (3), 11854392 (1), 19666078 (1), 11710520 (1) (see all 10)
    chemically induced 17.4 3 9210956 (1), 7585625 (1)
    carcinoma bronchogenic 16.5 2 2011143 (1), 1707592 (1)
    laryngeal cancer 15.3 7 15127559 (5), 12772461 (1), 14639127 (1)
    bladder cancer 14.7 17 18979064 (4), 15036656 (1), 19443378 (1), 10022250 (1) (see all 6)
    xeroderma pigmentosum 14.4 3 7923575 (1), 11378441 (1), 8353849 (1)
    hnscc 13 8 14724908 (2), 12748560 (2), 9486585 (1), 12269988 (1) (see all 5)
    mammary tumor 12.3 1 11097088 (1)
    laryngeal squamous cell carcinoma 11.9 2 15914211 (1), 14639127 (1)
    carcinoma basal cell 11.9 3 16582078 (1), 8824510 (1)
    aml adult 10.2 2 15194533 (2)
    lymphoblastic leukemia acute 9.71 3 18414197 (2), 15528152 (1)
    neck cancer 5.64 6 14693745 (2), 9486585 (2), 18590468 (2)
    preterm delivery 5.59 11 18589596 (4), 15605089 (2), 18706519 (1), 11097796 (1) (see all 5)
    lupus erythematosus systemic 4.54 4 20226777 (2), 14611903 (1)
    osteoporosis 4.47 1 15647817 (1)
    carcinoma 4.25 11 9139841 (2), 11953897 (1), 12144816 (1), 19160101 (1) (see all 9)
    colorectal cancer 3.79 30 19452301 (4), 16620591 (4), 18768509 (3), 10769717 (2) (see all 13)
    necrosis 3.62 3 9756946 (1), 11470802 (1), 11325850 (1)
    chromosomal aberrations 3.58 3 11535253 (1), 15470755 (1), 9820667 (1)
    tumors 3.38 54 11468695 (3), 18172554 (3), 14707267 (3), 9077484 (2) (see all 39)
    coronary artery disease 3.33 2 19563927 (1), 17408703 (1), 17711714 (1)
    colon carcinoma 3.06 3 12655030 (1), 12210751 (1), 17177569 (1)
    metaplasia 3.01 3 15547760 (1), 11127289 (1), 10463577 (1)
    hepatitis c 2.89 2 12569554 (1), 16788090 (1)
    liver diseases 2.71 9 1802352 (3), 12569554 (2), 9063816 (1)
    chronic disease 2.65 1 14593914 (1)
    esophageal carcinoma 2.63 10 9307183 (2), 12854128 (2), 11860900 (1), 19427967 (1)
    calcification 2.52 5 1736417 (3), 9857304 (2)
    cardiovascular diseases 2.23 1 15805301 (1)
    pneumonia 1.33 5 15928955 (3), 11372593 (2)
    melanoma 1.25 2 16998606 (2)
    metastasis 0.108 3 9825835 (1), 2021546 (1)
    pregnancy loss 0 4 15333597 (2), 15299091 (2)
    lung tumor 0 3 17163506 (1), 9784250 (1), 20484175 (1)
    poisoning 0 3 16737584 (2), 17479406 (1)
    leukemia 0 11 15298960 (3), 16284498 (2), 18414197 (1), 16980705 (1) (see all 8)
    breast diseases 0 1 16808847 (1)
    barrett esophagus 0 1 10933049 (1)
    skin cancer 0 2 10651994 (1), 17083362 (1)
    cervical cancer 0 3 16360200 (2), 17512722 (1)
    chronic liver disease 0 1 19643819 (1)
    wasting syndrome 0 1 15900503 (1)
    shock 0 3 16039398 (2), 16968971 (1)
    colon cancer 0 4 15496536 (2), 12210502 (1), 12210751 (1)
    colorectal carcinoma 0 1 17159770 (1)
    primary tumor 0 2 14743400 (1), 8706015 (1)
    inflammation 0 5 11205134 (1), 19152381 (1), 17888717 (1), 20307623 (1)
    ovarian carcinoma 0 2 12144816 (1), 12655030 (1)
    glioma 0 6 9641501 (3), 16968971 (2), 17372252 (1)
    polyps 0 2 16926176 (1)
    cirrhosis 0 7 1802352 (3)
    gastric cancer 0 20 20047124 (4), 15929164 (3), 15547760 (3), 16337337 (3) (see all 7)
    infertility 0 1 18774560 (1)
    lymphoma non-hodgkins 0 3 11406608 (1), 12397416 (1), 16985026 (1)
    adenoma 0 1 17363580 (1)
    atherosclerosis 0 1 11996959 (1)
    tumor liver 0 1 19514916 (1)
    nsclc 0 21 8706015 (3), 19608585 (3), 9918134 (2), 10493307 (2) (see all 8)
    benign prostatic hyperplasia 0 1 10964100 (1)
    parkinson disease 0 3 11484167 (2), 11793160 (1)
    leukemogenesis 0 1 10029576 (1)
    small cell lung cancer 0 3 7586131 (2), 11778487 (1)
    miscarriage 0 1 15299091 (1)
    lymphoma 0 4 11406608 (1), 18174961 (1), 18849443 (1), 12397416 (1)
    premalignant 0 2 15547760 (1)
    germ-line mutation 0 1 10542949 (1)
    cell damage 0 1 18824009 (1)
    pulmonary disease chronic obstructive 0 3 14593914 (2), 18389617 (1)
    precancerous lesions 0 3 12854128 (1), 12269988 (1), 17307803 (1)
    nasopharyngeal carcinoma 0 3 19954069 (2), 12582034 (1)
    carcinoma renal cell 0 6 9631944 (2), 12655030 (1), 15017268 (1), 15355884 (1) (see all 5)

    Genetic Association Database (GAD): CYP1A1
    Human Genome Epidemiology (HuGE) Navigator: CYP1A1 (699 documents)

    Export disorders for CYP1A1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CYP1A1 gene, integrated from 10 sources (see all 1899):
    (articles sorted by number of sources associating them with CYP1A1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Variation in induced CYP1A1 levels: relationship to CYP1A1, Ah receptor and GSTM1 polymorphisms. (PubMed id 10739168)1, 2, 9 Smart J. and Daly A.K. (Pharmacogenetics 2000)
    2. [Relationship between CYP1A1, GSTM1 genetic polymorphisms and susceptibility to esophageal squamous cell carcinoma]. (PubMed id 11860825)1, 4, 9 Shao G....Wen B. (Zhonghua Liu Xing Bing Xue Za Zhi 2000)
    3. Evidence for increased cytochrome P450 1A1 expression in blood lymphocytes of lung cancer patients. (PubMed id 19632247)1, 4, 9 Shah P.P....Parmar D. (Mutat. Res. 2009)
    4. [Relationship between susceptibility and prognosis of laryngeal cancer and genetic polymorphisms in CYP1A1 and GSTM1]. (PubMed id 15127559)1, 4, 9 Li L....Lu H.H. (Zhonghua Er Bi Yan Hou Ke Za Zhi 2004)
    5. CYP1A1 gene polymorphism and risk of epithelial ovarian neoplasm. (PubMed id 12144816)1, 4, 9 Aktas D....Ayhan A. (Gynecol. Oncol. 2002)
    6. Possible risk modification by CYP1A1, GSTM1 and GSTT1 gene polymorphisms in lung cancer susceptibility in a South Indian population. (PubMed id 16228113)1, 4, 9 Sreeja L....Ankathil R. (J. Hum. Genet. 2005)
    7. [Relationship between CYP1A1 gene polymorphisms and urinary 1-hydroxypyrene levels in coke oven workers]. (PubMed id 19538838)1, 4, 9 Nie J.S....Niu Q. (Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2009)
    8. CYP1A1 and GSTM1 polymorphisms and oral cancer risk: association studies via evidence-based meta-analyses. (PubMed id 19160101)1, 4, 9 Zhuo W....Chen Z. (Cancer Invest. 2009)
    9. CYP1A1, SULT1A1, and SULT1E1 polymorphisms are risk factors for endometrial cancer susceptibility. (PubMed id 18318428)1, 4, 9 Hirata H....Dahiya R. (Cancer 2008)
    10. Riluzole metabolism and CYP1A1/2 polymorphisms in patients with ALS. (PubMed id 17852022)1, 4, 9 Ajroud-Driss S....Lukas T.J. (Amyotroph Lateral Scler 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1543 HGNC: 2595 AceView: CYP1A1 Ensembl:ENSG00000140465 euGenes: HUgn1543
    ECgene: CYP1A1 Kegg: 1543 H-InvDB: CYP1A1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CYP1A1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CYP1A1 Genetics and Cytogenetics in Oncology and Haematology
    Cytochrome P450 Allele Nomenclature Committeehttp://www.cypalleles.ki.se/cyp1a1.htm
    SHMPDhttp://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=CYP1A1
    Wikipedia http://en.wikipedia.org/wiki/CYP1A1

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CYP1A1 gene:
    Search GeneIP for patents involving CYP1A1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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