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CYP1A1 Gene

protein-coding   GIFtS: 74
GCID: GC15M075011

Cytochrome P450, Family 1, Subfamily A, Polypeptide 1

(Previous names: cytochrome P450, subfamily I (aromatic compound-inducible),...)
(Previous symbol: CYP1)
  See CYP1A1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cytochrome P450, Family 1, Subfamily A, Polypeptide 11 2     CP112
CYP11 2 5     P1-4502
Cytochrome P450, Subfamily I (Aromatic Compound-Inducible), Polypeptide 11 2     P450-C2
Cytochrome P450 Form 62 3     P450DX2
Cytochrome P450-C2 3     Aryl Hydrocarbon Hydroxylase2
Cytochrome P450-P12 3     Cytochrome P1-450, Dioxin-Inducible2
CYPIA12 3     Cytochrome P450 1A12
EC 1.14.14.13 8     Flavoprotein-Linked Monooxygenase2
AHH2     Xenobiotic Monooxygenase2
AHRR2     

External Ids:    HGNC: 25951   Entrez Gene: 15432   Ensembl: ENSG000001404657   OMIM: 1083305   UniProtKB: P047983   

Export aliases for CYP1A1 gene to outside databases

Previous GC identifers: GC15M068848 GC15M068126 GC15M072587 GC15M072727 GC15M072798 GC15M051809


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CYP1A1 Gene:
This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins
are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol,
steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by
some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous
substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has
been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from
CYP1A1 on chromosome 15. (provided by RefSeq, Jul 2008)

GeneCards Summary for CYP1A1 Gene:
CYP1A1 (cytochrome P450, family 1, subfamily A, polypeptide 1) is a protein-coding gene. Diseases associated with CYP1A1 include basal cell carcinoma, multiple, and oral cancer. GO annotations related to this gene include iron ion binding and enzyme binding. An important paralog of this gene is CYP1A2.

UniProtKB/Swiss-Prot: CP1A1_HUMAN, P04798
Function: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is
involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated
compounds, including steroids, fatty acids, and xenobiotics

Gene Wiki entry for CYP1A1 (Cytochrome P450, family 1, member A1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000015.9  NT_010194.18  NC_018926.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CYP1A1 gene promoter:
         GR   C/EBPbeta   p53   SREBP-1c   Bach2   SREBP-1b   HNF-4alpha1   MZF-1   SREBP-1a   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): CYP1A1 promoter sequence
   Search Chromatin IP Primers for CYP1A1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CYP1A1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q24.1   Ensembl cytogenetic band:  15q24.1   HGNC cytogenetic band: 15q24.1

CYP1A1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CYP1A1 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M075011:  view genomic region     (about GC identifiers)

Start:
75,011,883 bp from pter      End:
75,017,951 bp from pter
Size:
6,069 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CP1A1_HUMAN, P04798 (See protein sequence)
Recommended Name: Cytochrome P450 1A1  
Size: 512 amino acids; 58165 Da
Cofactor: Heme group
1 PDB 3D structure from and Proteopedia for CYP1A1:
4I8V (3D)    
Secondary accessions: A4F3V9 A4F3W0 Q53G18
Alternative splicing: 3 isoforms:  P04798-1   P04798-2   P04798-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CYP1A1: NX_P04798

Explore proteomics data for CYP1A1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for CYP1A1 (P04798) (see all 25)
     FSIASDP  PILRYLP  NQWQINH  ELDTVIG 


    See CYP1A1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000490.1  
    ENSEMBL proteins: 
     ENSP00000369050   ENSP00000456585   ENSP00000378489   ENSP00000455340   ENSP00000457668  
     ENSP00000455051   ENSP00000455846   ENSP00000378488  
    Reactome Protein details: P04798

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CYP: Cytochrome P450s

    IUPHAR Guide to PHARMACOLOGY protein family classification: CYP1A1
    CYP1 family

    4 InterPro protein domains:
     IPR001128 Cyt_P450
     IPR017972 Cyt_P450_CS
     IPR002401 Cyt_P450_E_grp-I
     IPR008066 Cyt_P450_E_grp-I_CYP1

    Graphical View of Domain Structure for InterPro Entry P04798

    ProtoNet protein and cluster: P04798

    2 Blocks protein domains:
    IPB002401 E-class P450 group I signature
    IPB008066 CYP1A P450 family signature


    UniProtKB/Swiss-Prot: CP1A1_HUMAN, P04798
    Similarity: Belongs to the cytochrome P450 family


    Find genes that share domains with CYP1A1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CP1A1_HUMAN, P04798
    Function: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is
    involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated
    compounds, including steroids, fatty acids, and xenobiotics
    Catalytic activity: RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O
    Induction: By 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)

         Genatlas biochemistry entry for CYP1A1:
    cytochrome p450,family I (polycytic aromatic compound-inducible),member A1 (see CYP1@),associated with
    susceptibility to lung squamous cell carcinoma and to childhood acute lymphoblastic leukemia (in association with
    deletion of GSTM1)

         Enzyme Number (IUBMB): EC 1.14.14.11 2

         Gene Ontology (GO): Selected molecular function terms (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004497monooxygenase activity ----
    GO:0005506iron ion binding IEA--
    GO:0005515protein binding ----
    GO:0008395steroid hydroxylase activity IEA--
         
    Find genes that share ontologies with CYP1A1           About GenesLikeMe


    Phenotypes:
         9 MGI mutant phenotypes (inferred from 7 alleles(MGI details for Cyp1a1):
     cardiovascular system  growth/size/body  hematopoietic system  homeostasis/metabolism  immune system 
     liver/biliary system  mortality/aging  no phenotypic analysis  normal 

    Find genes that share phenotypes with CYP1A1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for CYP1A1: Cyp1a1tm1.1Dwn Cyp1a2/Cyp1a1Cyp1a2/tm2Dwn Cyp1a2/Cyp1a1Cyp1a2/tm1.1Bra

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    SwitchGear 3'UTR luciferase reporter plasmidCYP1A1 3' UTR sequence
    Inhib. RNA
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CYP1A1

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYP1A1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CP1A1_HUMAN, P04798: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral
    membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    nucleus3
    cytosol2
    mitochondrion2
    cytoskeleton1
    extracellular1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005739mitochondrion IEA--
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0043231intracellular membrane-bounded organelle ----

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    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CYP1A1 About   (see all 18)  
    See pathways by source

    SuperPathContained pathways About
    1Biological oxidations
    Biological oxidations0.56
    Tamoxifen metabolism0.00
    metapathway biotransformation0.42
    Estradiol metabolism0.00
    Benzo(a)pyrene metabolism0.00
    Acetaminophen metabolism0.00
    2Cytochrome P450 - arranged by substrate type
    Cytochrome P450 - arranged by substrate type0.75
    Xenobiotics0.00
    Phase 1 - Functionalization of compounds0.75
    Fatty Acid Omega Oxidation0.00
    cytochrome P4500.74
    3Arachidonic acid metabolism
    Arachidonic acid metabolism0.40
    Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)0.00
    Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)0.00
    Amodiaquine Pathway, Pharmacokinetics0.00
    4Chemical carcinogenesis
    Chemical carcinogenesis0.71
    Retinol metabolism0.35
    Metabolism of xenobiotics by cytochrome P4500.71
    Benzo a pyrene metabolism0.00
    5Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    Metabolic pathways0.38


    Find genes that share SuperPaths with CYP1A1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for CYP1A1
        AHR Pathway

    Selected GeneGo (Thomson Reuters) Pathways for CYP1A1 (see all 7)
        Estradiol metabolism
    Retinol metabolism
    Naphthalene metabolism
    2-Naphthylamine and 2-Nitronaphtalene metabolism
    Benzo[a]pyrene metabolism

    Selected BioSystems Pathways for CYP1A1 (see all 9)
        cytochrome P450
    Oxidative Stress
    Tamoxifen metabolism
    Benzo(a)pyrene metabolism
    Estrogen metabolism


    4 Reactome Pathways for CYP1A1
        Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)
    Xenobiotics
    PPARA activates gene expression
    Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)

    Selected PharmGKB Pathways for CYP1A1 (see all 6)
        Acetaminophen Pathway, Pharmacokinetics
    Amodiaquine Pathway, Pharmacokinetics
    Erlotinib Pathway, Pharmacokinetics
    Estrogen Metabolism Pathway
    Gefitinib Pathway, Pharmacokinetics

    Selected Kegg Pathways  (Kegg details for CYP1A1) (see all 7):
        Steroid hormone biosynthesis
    Tryptophan metabolism
    Retinol metabolism
    Metabolism of xenobiotics by cytochrome P450
    Metabolic pathways

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CYP1A1 (see all 6): 
              Estrogen Receptor Signaling in human mouse rat
              Cancer Drug Resistance in human mouse rat
              Drug Metabolism: Phase I Enzymes in human mouse rat
              Cellular Stress Responses in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CYP1A1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CYP1A1 (P047983 ENSP000003690504) via UniProtKB, MINT, STRING, and/or I2D (see all 92)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CYB5AP001673, ENSP000003416254I2D: score=1 STRING: ENSP00000341625
    HSPA4P349323, ENSP000003029614I2D: score=1 STRING: ENSP00000302961
    HSP90AA1P079003, ENSP000003351534I2D: score=1 STRING: ENSP00000335153
    AKR1C1ENSP000003702544STRING: ENSP00000370254
    AKR1C3ENSP000003699274STRING: ENSP00000369927
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 47):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001666response to hypoxia IEA--
    GO:0001889liver development ----
    GO:0006778porphyrin-containing compound metabolic process IEA--
    GO:0006805xenobiotic metabolic process TAS--
    GO:0007568aging IEA--

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    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CYP1A1 (CP1A1)

    Selected HMDB Compounds for CYP1A1 (see all 54)    About this table
    CompoundSynonyms CAS #PubMed Ids
    Melatonin5-Methoxy-N-acetyltryptamine (see all 23)73-31-419919601
    10-HETE10-hydroxyeicosa-all-cis-5,8,11,14-tetraenoate (see all 2)167697-52-1--
    11,12,15-THETA11,12,15-Trihydroxyicosatrienoic acid (see all 5)----
    11,12-Epoxyeicosatrienoic acid10-(3-(2-octenyl)oxiranyl)-5,8-Decadienoic acid (see all 15)81276-02-0--
    11,14,15-THETA(5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoic acid (see all 8)----
    11H-14,15-EETA14,15-Ep-11-HETrE (see all 11)219535-29-2--
    11beta-Hydroxytestosterone11beta,17beta-dihydroxyandrost-4-en-3-one 1816-85-9--
    12,13-EpOMEVernolic acid (see all 12)----
    13-HETE13-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoate (see all 2)151910-72-4--
    14,15-Epoxy-5,8,11-eicosatrienoic acid(5Z,8Z,11Z)-14,15-Epoxyicosa-5.8.11-trienoic acid (see all 11)81276-03-1--

    Selected DrugBank Compounds for CYP1A1 (see all 90)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    ErlotinibCP358774 (see all 2)183321-74-6enzymesubstrate17575239 16166415 19733976
    MelatoninMEL (see all 4)73-31-4enzymesubstrate inhibitor19919601 15616152 19934256
    TamoxifenICI-46474 (see all 3)10540-29-1enzymesubstrate12124303 19934256 19515014
    AmiodaroneAmiodarona [INN-Spanish] (see all 5)1951-25-3enzymesubstrate18445370 19934256
    AmlodipineAmlodipine Benzenesulfonate (see all 6)88150-42-9enzymeinhibitor10805063 19934256
    Benzyl alcohol(Hydroxymethyl)benzene (see all 10)100-51-6enzyme--9065730 9726784
    ChlorzoxazoneChloroxazone (see all 3)95-25-0enzymesubstrate15231049 20164110
    Cinnarizine-- 298-57-7enzymesubstrate19934256 19515014
    Dasatinib-- 302962-49-8enzymesubstrate18556438 19733976
    Ellagic Acid-- 476-66-4enzymeinhibitor inducer8024593 19469472

    Selected Novoseek inferred chemical compound relationships for CYP1A1 gene (see all 140)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tcdd 94 698 8396892 (9), 15630080 (7), 11728381 (6), 9931287 (6) (see all 99)
    ethoxyresorufin 91.1 84 17959138 (4), 8093105 (3), 11599655 (2), 8396892 (1) (see all 67)
    benzo(a)pyrene 89.7 376 18372000 (6), 19330882 (6), 16280210 (6), 10503953 (6) (see all 99)
    alpha-naphthoflavone 88.1 64 1329656 (4), 12628305 (2), 2115161 (2), 1315629 (1) (see all 38)
    3-methylcholanthrene 86.4 193 12941938 (7), 16137816 (4), 17276403 (3), 9465551 (3) (see all 64)
    hydrocarbons 85.2 131 8954573 (2), 17630984 (2), 19362136 (2), 8353849 (2) (see all 99)
    mspi 84.8 71 1284589 (4), 8706015 (3), 8877059 (3), 8983277 (2) (see all 51)
    beta-naphthoflavone 82.9 79 11076701 (3), 12147246 (3), 18502397 (3), 19470599 (3) (see all 36)
    4-methoxyestradiol 79.6 1 10403516 (1)
    benz(a)anthracene 78.8 30 1700499 (4), 8920757 (2), 1358564 (2), 1654865 (2) (see all 14)

    6 PharmGKB related drug/compound annotations for CYP1A1 gene    About this table
    Drug/compound PharmGKB Annotation
    capecitabineCA  
    dexlansoprazole
    docetaxelCA  
    drospirenone
    ethinyl estradiol
    tiotropium



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    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CYP1A1 gene: 
    NM_000499.3  

    Unigene Cluster for CYP1A1:

    Cytochrome P450, family 1, subfamily A, polypeptide 1
    Hs.72912  [show with all ESTs]
    Unigene Representative Sequence: NM_000499
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000379727(uc002ayq.4 uc010bjy.3) ENST00000567032 ENST00000395049
    ENST00000562201 ENST00000564596(uc010bjz.1) ENST00000569630 ENST00000566503
    ENST00000395048(uc002ayp.4 uc010bju.3 uc010bjv.3 uc010bjw.3 uc010bjx.3)

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    GenScript: all cDNA clones in your preferred vector: CYP1A1 (NM_000499)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CYP1A1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CYP1A1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CYP1A1
    OriGene qSTAR qPCR primer pairs in human, mouse for CYP1A1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CYP1A1
      QuantiTect SYBR Green Assays in human, mouse, rat CYP1A1
      QuantiFast Probe-based Assays in human, mouse, rat CYP1A1

    Additional mRNA sequence: 

    AK223108.1 AK223113.1 AK310810.1 AK313880.1 AM233517.1 AM233518.1 AM233519.1 AM233520.1 
    AM236046.1 AM236047.1 AY310359.1 AY871801.1 BC023019.1 K03191.1 M12079.1 

    2 DOTS entries:

    DT.310017  DT.100744671 

    Selected AceView cDNA sequences (see all 52):

    AI417887 BU620769 BC023019 AL600919 AV656441 NM_000499 BQ878741 AW451941 
    AL600881 CA423835 AL600770 AW949660 BQ005861 CB267342 CA439920 BU941041 
    CB163693 AH007293 CB265483 AA418907 BP353358 CA426401 AL598760 BU182605 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for CYP1A1    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
    SP1:                                                
    SP2:                                                


    ECgene alternative splicing isoforms for CYP1A1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    CYP1A1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTGCATAAG
    CYP1A1 Expression
    About this image


    CYP1A1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Liver (Hepatobiliary System)
             Perivenous Hepatocytes Liver Lobule
     
     Adipose (Muscoskeletal System)    fully expand to see all 2 entries
             Interscapular Brown Adipose Depot
             HyStem+BMP4-induced 7SMOO32 cells
     
     Lung (Respiratory System)
             Basal Cells Respiratory Bronchioles
     
     Placenta (Extraembryonic Tissues)
             Syncytiotrophoblast-like cells
    CYP1A1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CYP1A1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.72912

    UniProtKB/Swiss-Prot: CP1A1_HUMAN, P04798
    Tissue specificity: Lung, lymphocytes and placenta

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CYP1A1 (see all 6): 
              Estrogen Receptor Signaling in human mouse rat
              Cancer Drug Resistance in human mouse rat
              Drug Metabolism: Phase I Enzymes in human mouse rat
              Cellular Stress Responses in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CYP1A1
    OriGene qSTAR qPCR primer pairs in human, mouse for CYP1A1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CYP1A1
    QuantiTect SYBR Green Assays in human, mouse, rat CYP1A1
    QuantiFast Probe-based Assays in human, mouse, rat CYP1A1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYP1A1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CYP1A1 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cyp1a11 , 5 cytochrome P450, family 1, subfamily a, polypeptide more1, 5 82.61(n)1
    80.39(a)1
      9 (31.34 cM)5
    130761  NM_001136059.21  NP_001129531.11 
     576976135 
    chicken
    (Gallus gallus)
    Aves CYP1A11 cytochrome P450, family 1, subfamily A, polypeptide more 67.06(n)
    62.4(a)
      396051  NM_205146.2  NP_990477.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 3)
    Uncharacterized protein
    (see all 3)
    60(a)
    58(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    GL343721.1(50982-63103)
    GL343721.1(108802-116982)
    African clawed frog
    (Xenopus laevis)
    Amphibia AB022087.12   -- 71.3(n)    AB022087.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cyp1a12 cytochrome P450, subfamily I, polypeptide 1 74.16(n)   140634  AB078927.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Cyp18a13 steroid biosynthesis cytochrome P450 32(a)
    (best of 2)
      17D1   --
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons CYP93D11 CYP93D1 40.54(n)
    28.05(a)
      830580  NM_120772.1  NP_196307.1 
    rice
    (Oryza sativa)
    Liliopsida Os06g06136001 Os06g0613600 45.38(n)
    31.3(a)
      4341526  NM_001064607.1  NP_001058072.1 


    ENSEMBL Gene Tree for CYP1A1 (if available)
    TreeFam Gene Tree for CYP1A1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CYP1A1 gene
    CYP1A22  CYP1B12  CYP17A12  CYP21A22  
    Selected SIMAP similar genes for CYP1A1 using alignment to 8 protein entries:     CP1A1_HUMAN (see all proteins) (see all similar genes):
    CYP1A2    CYP1B1    CYP4V2    CYP2U1    DKFZp686I24235    CYP2D6
    CYP2S1    CYP2A13    CYP2A6    CYP2A7    CYP21A2    CYP2F1
    CYP2R1    CYP2C8    CYP2J2    CYP2B7    CYP2A6V2    CYP2G1P

    Find genes that share paralogs with CYP1A1           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for CYP1A1
    PGOHUM00000236640


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CYP1A1 (see all 294)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1494232661,2
    --55062351(+) AGGGCA/GTAAGT 1 -- ds50010--------
    rs456271341,2
    C,F--55062527(-) CGCAGG/CCACAC 1 -- ds50015Minor allele frequency- C:0.01NS 176
    rs798120151,2
    F--55062576(+) GAGCCT/CGGAGG 1 -- ds50011Minor allele frequency- C:0.39PA 802
    rs46469031,2
    C,F,A,H--55062577(-) CCTCCA/C/TGGGCT 1 -- ds500117NA MN NS WA CSA EA 934
    rs1397748601,2
    --55062715(+) TGCTAC/TCTCCT 1 -- ds50010--------
    rs1889132831,2
    C--55062779(+) TTAGAC/GGAGTG 1 -- ds50010--------
    rs1817168151,2
    --55062780(+) TAGACA/GAGTGA 1 -- ds50010--------
    rs24723071,2
    C,H--55062791(+) TGAATC/TATTTA 1 -- ds500111Minor allele frequency- T:0.00NS EA NA MN 812
    rs1853831341,2
    --55062910(+) ATTAAA/CTCAAT 1 -- ut310--------
    rs178610841,2
    C,F--55062955(+) ATGCAG/TGCTAG 1 -- ut3111Minor allele frequency- T:0.06MN NS WA 714

    HapMap Linkage Disequilibrium report for CYP1A1 (75011883 - 75017951 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for CYP1A1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv904380CNV Loss21882294
    nsv904379CNV Loss21882294
    nsv833055CNV Loss17160897
    nsv817698CNV Gain17921354

    The Human Cytochrome P450 Allele Nomenclature Database: CYP1A1 
    Human Gene Mutation Database (HGMD): CYP1A1
    Locus Specific Mutation Databases (LSDB): CYP1A1

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CYP1A1
    DNA2.0 Custom Variant and Variant Library Synthesis for CYP1A1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 108330    OMIM disorders: --

    11 diseases for CYP1A1:    
    About MalaCards
    basal cell carcinoma, multiple    oral cancer    cardia cancer    basal cell carcinoma
    leukoplakia    barrett's esophagus    endometriosis    lung cancer
    colorectal cancer    prostate cancer    breast cancer

    4 diseases from the University of Copenhagen DISEASES database for CYP1A1:
    Lung cancer     Hepatocellular carcinoma     Breast cancer     Carcinoma

    Find genes that share disorders with CYP1A1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for CYP1A1 gene (see all 93)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ahh inducibility 87.7 42 8126925 (5), 8609043 (5), 9465551 (5), 9731718 (4) (see all 10)
    cancer lung 68.2 293 9894148 (6), 11778487 (6), 16228113 (6), 10491856 (5) (see all 99)
    genetic susceptibility 61.7 23 18304461 (2), 10698723 (1), 19472123 (1), 20054510 (1) (see all 18)
    chemical carcinogenesis 58 6 12628305 (1), 19573549 (1), 12520071 (1), 11370663 (1) (see all 6)
    cancer 57.9 119 8552885 (3), 15355884 (3), 15805301 (2), 16402077 (2) (see all 91)
    breast cancer 57.1 155 9485019 (6), 20088394 (5), 11408954 (5), 16807674 (4) (see all 79)
    environmental carcinogenesis 56.6 1 18463401 (1)
    oral cancer 46 35 19469619 (5), 17461521 (4), 19160101 (3), 9332761 (3) (see all 10)
    adenocarcinoma lung 43.3 14 17200336 (2), 12824892 (2), 15375499 (2), 11955671 (1) (see all 8)
    carcinoma squamous cell 43.2 41 11778487 (3), 10435155 (2), 7554077 (2), 10793329 (2) (see all 30)

    Genetic Association Database (GAD): CYP1A1
    Human Genome Epidemiology (HuGE) Navigator: CYP1A1 (699 documents)

    Export disorders for CYP1A1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CYP1A1 gene, integrated from 10 sources (see all 1899) (see top 10):
    (articles sorted by number of sources associating them with CYP1A1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Variation in induced CYP1A1 levels: relationship to CYP1A1, Ah receptor and GSTM1 polymorphisms. (PubMed id 10739168)1, 2, 9 Smart J. and Daly A.K. (Pharmacogenetics 2000)
    2. [Relationship between CYP1A1, GSTM1 genetic polymorphisms and susceptibility to esophageal squamous cell carcinoma]. (PubMed id 11860825)1, 4, 9 Shao G....Wen B. (Zhonghua Liu Xing Bing Xue Za Zhi 2000)
    3. Evidence for increased cytochrome P450 1A1 expression in blood lymphocytes of lung cancer patients. (PubMed id 19632247)1, 4, 9 Shah P.P....Parmar D. (Mutat. Res. 2009)
    4. [Relationship between susceptibility and prognosis of laryngeal cancer and genetic polymorphisms in CYP1A1 and GSTM1]. (PubMed id 15127559)1, 4, 9 Li L....Lu H.H. (Zhonghua Er Bi Yan Hou Ke Za Zhi 2004)
    5. CYP1A1 gene polymorphism and risk of epithelial ovarian neoplasm. (PubMed id 12144816)1, 4, 9 Aktas D....Ayhan A. (Gynecol. Oncol. 2002)
    6. Possible risk modification by CYP1A1, GSTM1 and GSTT1 gene polymorphisms in lung cancer susceptibility in a South Indian population. (PubMed id 16228113)1, 4, 9 Sreeja L....Ankathil R. (J. Hum. Genet. 2005)
    7. [Relationship between CYP1A1 gene polymorphisms and urinary 1-hydroxypyrene levels in coke oven workers]. (PubMed id 19538838)1, 4, 9 Nie J.S....Niu Q. (Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2009)
    8. CYP1A1 and GSTM1 polymorphisms and oral cancer risk: association studies via evidence-based meta-analyses. (PubMed id 19160101)1, 4, 9 Zhuo W....Chen Z. (Cancer Invest. 2009)
    9. CYP1A1, SULT1A1, and SULT1E1 polymorphisms are risk factors for endometrial cancer susceptibility. (PubMed id 18318428)1, 4, 9 Hirata H....Dahiya R. (Cancer 2008)
    10. Riluzole metabolism and CYP1A1/2 polymorphisms in patients with ALS. (PubMed id 17852022)1, 4, 9 Ajroud-Driss S....Lukas T.J. (Amyotroph Lateral Scler 2007)
    11. Polymorphisms of CYP1A1 and GSTM1 genes and susceptibility to oral cancer. (PubMed id 17461521)1, 4, 9 Cha I.H....Park K.K. (Yonsei Med. J. 2007)
    12. [Association between genetic polymorphisms of metabolic enzymes and susceptibility of colorectal cancer]. (PubMed id 16620591)1, 4, 9 Fan C.H....Chen K. (Zhonghua Yu Fang Yi Xue Za Zhi 2006)
    13. Effect of CYP1A1 gene polymorphisms on estrogen metabolism and bone density. (PubMed id 15647817)1, 4, 9 Napoli N....Armamento-Villareal R. (J. Bone Miner. Res. 2005)
    14. CYP1A1 polymorphism and risk of gynecological malignancy in Japan. (PubMed id 14675315)1, 4, 9 Sugawara T....Fujimoto S. (Int. J. Gynecol. Cancer 2003)
    15. Aromatic DNA adducts and polymorphisms of CYP1A1, NAT2, and GSTM1 in breast cancer. (PubMed id 11872636)1, 4, 9 Firozi P.F....Li D. (Carcinogenesis 2002)
    16. CYP1A1, cigarette smoking, and colon and rectal cancer. (PubMed id 15496536)1, 4, 9 Slattery M.L....Neuhausen S. (Am. J. Epidemiol. 2004)
    17. Genetic polymorphisms and transcriptional pattern analysis of CYP1A1, AhR, GSTM1, GSTP1 and GSTT1 genes in breast cancer. (PubMed id 11408954)1, 4, 9 Dialyna I.A....Spandidos D.A. (Int. J. Mol. Med. 2001)
    18. Polymorphisms of the CYP1A1 and GSTM1 genes in relation to individual susceptibility to lung carcinoma in Chinese population. (PubMed id 11406420)1, 4, 9 Chen S....Wu J. (Mutat. Res. 2001)
    19. Association studies of CYP1A1 and GSTM1 polymorphisms with esophageal cancer risk: evidence-based meta-analyses. (PubMed id 19427967)1, 4, 9 Zhuo W.L....Chen Z.T. (Arch. Med. Res. 2009)
    20. Combination of TNF-RII, CYP1A1 and GSTM1 polymorphisms and the risk of Japanese SLE: findings from the KYSS study. (PubMed id 19561157)1, 4, 9 Horiuchi T....Takahashi H. (Rheumatology (Oxford) 2009)
    21. Association between polymorphisms in the biometabolism genes CYP1A1, GSTM1, GSTT1 and GSTP1 in bladder cancer. (PubMed id 18979064)1, 4, 9 Grando J.P....de Syllos CA^lus I.M. (Clin. Exp. Med. 2009)
    22. Association between dietary heterocyclic amine levels, genetic polymorphisms of NAT2, CYP1A1, and CYP1A2 and risk of colorectal cancer: a hospital-based case-control study in Japan. (PubMed id 19452301)1, 4, 9 Kobayashi M....Tsugane S. (Scand. J. Gastroenterol. 2009)
    23. GSTM1, GSTT1 and CYP1A1 polymorphisms and risk of oral cancer: a case-control study in Jakarta, Indonesia. (PubMed id 19469619)1, 4, 9 Amtha R....Purwanto D. (Asian Pac. J. Cancer Prev. 2009)
    24. Association between dietary heterocyclic amine levels, genetic polymorphisms of NAT2, CYP1A1, and CYP1A2 and risk of stomach cancer: a hospital-based case-control study in Japan. (PubMed id 20047124)1, 4, 9 Kobayashi M....Tsugane S. (Gastric Cancer 2009)
    25. [Association of cytochrome P450 genes polymorphisms (CYP1A1 and CYP1A2) with the development of chronic obstructive pulmonary disease in Bashkortostan]. (PubMed id 18389617)1, 4, 9 Korytina G.F....Viktorova T.V. (Mol. Biol. (Mosk.) 2008)
    26. Cytochrome P450 1A1 (CYP1A1) T3801C and A2455G polymorphisms in breast cancer risk: a meta-analysis. (PubMed id 17427032)1, 4, 9 Chen C....Xie Y. (J. Hum. Genet. 2007)
    27. [Allelic variants of cytochrome P4501A1 (CYP1A1), glutathione S transferase M1 (GSTM1) polymorphisms and their association with smoking and alcohol consumption as gastric cancer susceptibility biomarkers]. (PubMed id 17171211)1, 4, 9 Lee K....QuiA+ones S L. (Rev Med Chil 2006)
    28. Maternal smoking during pregnancy and genetic polymorphisms in the Ah receptor, CYP1A1 and GSTM1 affect infant birth size in Japanese subjects. (PubMed id 16481407)1, 4, 9 Sasaki S....Kishi R. (Mol. Hum. Reprod. 2006)
    29. Cigarette smoking, cytochrome P4501A1 polymorphisms, and breast cancer among African-American and white women. (PubMed id 15217514)1, 4, 9 Li Y....Conway K. (Breast Cancer Res. 2004)
    30. CYP1A1 and GSTM1 polymorphic genotypes in patients with prostate cancer in a Turkish population. (PubMed id 15381379)1, 4, 9 Aktas D....Tuncbilek E. (Cancer Genet. Cytogenet. 2004)
    31. Ah receptor, CYP1A1, CYP1A2 and CYP1B1 gene polymorphisms are not involved in the risk of recurrent pregnancy loss. (PubMed id 15299091)1, 4, 9 Saijo Y....Kishi R. (Mol. Hum. Reprod. 2004)
    32. Genetic polymorphism of the CYP1A1, CYP2E1, GSTM1 and GSTT1 genes and lung cancer susceptibility in a north indian population. (PubMed id 15646021)1, 4, 9 Sobti R.C....Janmeja A. (Mol. Cell. Biochem. 2004)
    33. CYP1A1, GSTM1 and GSTT1 genetic polymorphism is associated with susceptibility to polycystic ovaries in South Indian women. (PubMed id 15333250)1, 4, 9 Babu K.A....Singh L. (Reprod. Biomed. Online 2004)
    34. Structure and polymorphisms of human aryl hydrocarbon receptor repressor (AhRR) gene in a French population: relationship with CYP1A1 inducibility and lung cancer. (PubMed id 12777964)1, 4, 9 Cauchi S....Massaad-Massade L. (Pharmacogenetics 2003)
    35. [Association between gene mutation of cytochrome P450 1A1 in exon 7 A4889G locus and susceptibility to endometriosis]. (PubMed id 12903034)1, 4, 9 Peng D.X....Lin J.M. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2003)
    36. Studies on CYP1A1, CYP1B1 and CYP3A4 gene polymorphisms in breast cancer patients. (PubMed id 20088394)1, 4, 9 Ociepa-Zawal M....Trzeciak W.H. (Ginekol. Pol. 2009)
    37. Polymorphisms of Metabolizing Enzymes and Susceptibility to Ethmoid Intestinal-type Adenocarcinoma in Professionally Exposed Patients. (PubMed id 19412423)1, 4, 9 Pastore E....Pilotti S. (Transl Oncol 2009)
    38. Polymorphisms of GSTM1 and CYP1A1 genes and their genetic susceptibility to prostate cancer in Chinese men. (PubMed id 18304461)1, 4, 9 Li M....Na Y.Q. (Chin. Med. J. 2008)
    39. Lack of association among polymorphic xenobiotic-metabolizing enzyme genotypes and the occurrence and progression of oral carcinoma in a Brazilian population. (PubMed id 18507050)1, 4, 9 Losi-Guembarovski R....Ribeiro E.M. (Anticancer Res. 2008)
    40. Maternal cigarette smoking, metabolic gene polymorphisms, and preterm delivery: new insights on GxE interactions and pathogenic pathways. (PubMed id 18320229)1, 4, 9 Tsai H.J....Wang X. (Hum. Genet. 2008)
    41. [Polymorphisms of GSTM1, GSTT1 and CYP1A1 genes in mothers and neonates related to susceptibility to preterm delivery]. (PubMed id 18589596)1, 4, 9 Zhang M....et al . (Wei Sheng Yan Jiu 2008)
    42. Polymorphisms in xenobiotic-metabolizing genes and the risk of chronic lymphocytic leukemia and non-Hodgkin's lymphoma in adult Russian patients. (PubMed id 18061941)1, 4, 9 Gra O.A....Nasedkina T.V. (Am. J. Hematol. 2008)
    43. CYP1A1 and CYP1B1 genetic polymorphisms, smoking and breast cancer risk in a Finnish Caucasian population. (PubMed id 17063266)1, 4, 9 SillanpAoAo P....Hirvonen A. (Breast Cancer Res. Treat. 2007)
    44. Concurrent expression of aryl hydrocarbon receptor and CYP1A1 but not CYP1A1 MspI polymorphism is correlated with gastric cancers raised in Dalian, China. (PubMed id 16337337)1, 4, 9 Ma J.X....Liu J. (Cancer Lett. 2006)
    45. Potential differences in breast cancer risk factors based on CYP1A1 MspI and African-American-specific genotypes. (PubMed id 16599372)1, 4, 9 Zhu K....Williams S.M. (amp 2006)
    46. Germline genetic polymorphisms of CYP1A1, GSTM1 and GSTT1 genes in Indian cervical cancer: associations with tumor progression, age and human papillomavirus infection. (PubMed id 16360200)1, 4, 9 Joseph T....Pillai M.R. (Gynecol. Oncol. 2006)
    47. Toward the evaluation of function in genetic variability: characterizing human SNP frequencies and establishing BAC-transgenic mice carrying the human CYP1A1_CYP1A2 locus. (PubMed id 15643613)1, 2, 9 Jiang Z.... Nebert D.W. (Hum. Mutat. 2005)
    48. Effects of dietary intake and genetic factors on hypermethylation of the hMLH1 gene promoter in gastric cancer. (PubMed id 15991278)1, 4, 9 Nan H.M....Kim H. (World J. Gastroenterol. 2005)
    49. Cytochrome p4501A1 gene variants as susceptibility marker for prostate cancer. (PubMed id 17192049)1, 4, 9 Vijayalakshmi K....Paul S.F. (Cancer Biomark 2005)
    50. GSTM1, GSTT1 and CYP1A1 detoxification gene polymorphisms and their relationship with advanced stages of endometriosis in South Indian women. (PubMed id 15861041)1, 4, 9 Babu K.A....Shivaji S. (Pharmacogenet. Genomics 2005)
    51. CYP1A1, CYP2D6, CYP2E1, NAT2, GSTM1 and GSTT1 polymorphisms or their combinations are associated with the increased risk of the laryngeal squamous cell carcinoma. (PubMed id 15914211)1, 4, 9 Gajecka M....Szyfter K. (Mutat. Res. 2005)
    52. CYP1A1 and CYP1B1 genotypes, haplotypes, and TCDD-induced gene expression in subjects from Seveso, Italy. (PubMed id 15596250)1, 4, 9 Landi M.T....Bell D.A. (Toxicology 2005)
    53. Cytochrome P450 1A1 polymorphism and childhood leukemia: an analysis of matched pairs case-control genotype data. (PubMed id 15298960)1, 4, 9 Selvin S. (amp 2004)
    54. An investigation of mammographic density and gene variants in healthy women. (PubMed id 15382051)1, 4, 9 Maskarinec G....Le Marchand L. (Int. J. Cancer 2004)
    55. [Allelic distribution of the CYP1A1 in lung cancer patients, middle-aged tissue donors and in elderly people without cancer]. (PubMed id 15176217)1, 4, 9 Belogubova E.V....Imianitov E.N. (Vopr Onkol 2004)
    56. Genetic polymorphisms of CYP1A1, GSTM1 and GSTT1 genes and lung cancer risk. (PubMed id 14534704)1, 4, 9 Dialyna I.A....Spandidos D.A. (Oncol. Rep. 2003)
    57. Positive correlation between single or combined genotypes of CYP1A1 and GSTM1 in relation to prostate cancer in Chilean people. (PubMed id 12949934)1, 4, 9 Acevedo C....QuiA+ones SepA_lveda L. (Prostate 2003)
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    85. Association of polymorphisms in AhR, CYP1A1, GSTM1, and GSTT1 genes with levels of DNA damage in peripheral blood lymphocytes among coke-oven workers. (PubMed id 16985033)1, 4, 9 Chen Y....Wu T. (amp 2006)
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    155. Polymorphisms of drug-metabolizing enzymes CYP1A1, GSTT and GSTP contribute to the development of diffuse large B-cell lymphoma risk in the Saudi Arabian population. (PubMed id 18203021)1, 4, 9 Al-Dayel F....Al-Kuraya K. (amp 2008)
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    159. Polymorphism of CYP1A1*2C, GSTM1*0, and GSTT1*0 in a Mexican Mestizo population: a similitude analysis. (PubMed id 19317600)1, 4, 9 PAcrez-Morales R....Rubio J. (Hum. Biol. 2008)
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    166. Increased prevalence of EGFR-mutant lung cancer in women and in East Asian populations: analysis of estrogen-related polymorphisms. (PubMed id 18593984)1, 4, 9 Bell D.W....Haber D.A. (Clin. Cancer Res. 2008)
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    180. Susceptibility to pre-eclampsia is associated with multiple genetic polymorphisms in maternal biotransformation enzymes. (PubMed id 17167268)1, 4, 9 Zusterzeel P.L....Steegers E.A. (Gynecol. Obstet. Invest. 2007)
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    183. Primary DNA damage and genetic polymorphisms for CYP1A1, EPHX and GSTM1 in workers at a graphite electrode manufacturing plant. (PubMed id 17908297)1, 4, 9 Moretti M....Pasquini R. (BMC Public Health 2007)
    184. The risk of developing cervical cancer in Mexican women is associated to CYP1A1 MspI polymorphism. (PubMed id 17512722)1, 4, 9 JuA!rez-Cedillo T....Vargas-AlarcA^n G. (Eur. J. Cancer 2007)
    185. Pairwise combinations of estrogen metabolism genotypes in postmenopausal breast cancer etiology. (PubMed id 17372239)1, 4, 9 Rebbeck T.R....Strom B.L. (amp 2007)
    186. Genetic polymorphisms in estrogen-metabolizing genes and breast cancer survival. (PubMed id 17429315)1, 4, 9 Long J.R....Zheng W. (Pharmacogenet. Genomics 2007)
    187. GSTM1, GSTT1 and CYP1A1 detoxification gene polymorphisms and susceptibility to smoking-related coronary artery disease: a case-only study. (PubMed id 17408703)1, 4, 9 Manfredi S....Andreassi M.G. (Mutat. Res. 2007)
    188. Glutathione S-transferase and CYP1A1 gene polymorphisms and non-melanoma skin cancer risk in Italian transplanted patients. (PubMed id 17083362)1, 4, 9 Lira M.G....Tessari G. (Exp. Dermatol. 2006)
    189. Genetic polymorphisms and possible gene-gene interactions in metabolic and DNA repair genes: effects on DNA damage. (PubMed id 16043197)1, 4, 9 Naccarati A....Vodicka P. (Mutat. Res. 2006)
    190. Variation in genes relevant to aromatic hydrocarbon metabolism and the risk of adult brain tumors. (PubMed id 16598069)1, 4, 9 De Roos A.J....Inskip P.D. (Neuro-oncology 2006)
    191. Genetic polymorphism of metabolic enzymes modifies the risk of chronic solvent-induced encephalopathy. (PubMed id 17022435)1, 4, 9 Kezic S....Verberk M.M. (Toxicol Ind Health 2006)
    192. Association between metabolic gene polymorphisms and susceptibility to peripheral nerve damage in workers exposed to n-hexane: a preliminary study. (PubMed id 16484137)1, 4, 9 Zhang Y....Zheng Y. (Biomarkers 2006)
    193. GSTM1 and CYP1A1 polymorphisms, tobacco, air pollution, and lung cancer: a study in rural Thailand. (PubMed id 16614107)1, 4, 9 Pisani P....Bishop D.T. (amp 2006)
    194. CYP1A1 gene polymorphism and risk of endometrial hyperplasia and endometrial carcinoma. (PubMed id 16803538)1, 4, 9 Esinler I....Ayhan A. (Int. J. Gynecol. Cancer 2006)
    195. Genetic polymorphisms in CYP1A1 and GSTM1 predispose humans to PCBs/PCDFs-induced skin lesions. (PubMed id 16580705)1, 4, 9 Tsai P.C....Guo Y.L. (Chemosphere 2006)
    196. Association of DNA repair and steroid metabolism gene polymorphisms with clinical late toxicity in patients treated with conformal radiotherapy for prostate cancer. (PubMed id 16638864)1, 4, 9 Damaraju S....Parliament M. (Clin. Cancer Res. 2006)
    197. Influence of polymorphisms in xenobiotic-metabolizing genes and DNA-repair genes on diepoxybutane-induced SCE frequency. (PubMed id 17078101)1, 4, 9 Laczmanska I....Sasiadek M.M. (Environ. Mol. Mutagen. 2006)
    198. Combined CYP1A1/GSTM1 at-risk genotypes are overrepresented in squamous cell lung carcinoma patients but underrepresented in elderly tumor-free subjects. (PubMed id 16416283)1, 4, 9 Belogubova E.V....Imyanitov E.N. (J. Cancer Res. Clin. Oncol. 2006)
    199. Metabolic gene variants and risk of non-Hodgkin's lymphoma. (PubMed id 16985026)1, 4, 9 De Roos A.J....Severson R.K. (amp 2006)
    200. Oxidative stress-related gene polymorphism and the risk of preeclampsia. (PubMed id 15734083)1, 4, 9 Kim Y.J....Pang M.G. (Eur. J. Obstet. Gynecol. Reprod. Biol. 2005)
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    202. Maternal genetic polymorphisms in CYP1A1, GSTM1 and GSTT1 and the risk of hypospadias. (PubMed id 15579657)1, 4, 9 Kurahashi N....Kishi R. (Mol. Hum. Reprod. 2005)
    203. Cytochrome gene polymorphisms, serum estrogens, and hot flushes in midlife women. (PubMed id 16319265)1, 4, 9 Visvanathan K....Flaws J.A. (Obstet Gynecol 2005)
    204. CYP1A1 alleles in female genital cancers in the Polish population. (PubMed id 15653213)1, 4, 9 Seremak-Mrozikiewicz A....Mrozikiewicz P.M. (Eur. J. Obstet. Gynecol. Reprod. Biol. 2005)
    205. Role of xenobiotic metabolizing gene polymorphisms in breast cancer susceptibility and treatment outcome. (PubMed id 15725614)1, 4, 9 Chacko P....Pillai M.R. (Mutat. Res. 2005)
    206. Estrogen metabolism-related genes and breast cancer risk: the multiethnic cohort study. (PubMed id 16103451)1, 4, 9 Le Marchand L....Wilkens L.R. (amp 2005)
    207. An interethnic comparison of polymorphisms of the genes encoding drug-metabolizing enzymes and drug transporters: experience in Singapore. (PubMed id 15931768)1, 4, 9 Chowbay B....Lee E.J. (Drug Metab. Rev. 2005)
    208. Cytochrome P-450 1A1 gene polymorphisms and risk of breast cancer: a HuGE review. (PubMed id 15870154)1, 4, 9 Masson L.F....Little J. (Am. J. Epidemiol. 2005)
    209. Childhood leukaemia, polymorphisms of metabolism enzyme genes, and interactions with maternal tobacco, coffee and alcohol consumption during pregnancy. (PubMed id 16284498)1, 4, 9 Clavel J....Loriot M.A. (Eur. J. Cancer Prev. 2005)
    210. Cytochrome P4501A1 genetic polymorphisms and breast cancer risk in Nigerian women. (PubMed id 16254684)1, 4, 9 Okobia M....Kuller L. (Breast Cancer Res. Treat. 2005)
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    212. CYP1A1 and GSTM1 genetic polymorphisms in lung cancer populations exposed to arsenic in drinking water. (PubMed id 16012082)1, 4, 9 Adonis M....Gil L. ( the fate of foreign compounds in biological systems 2005)
    213. CYP1A1 and GSTM1 polymorphisms in relation to lung cancer risk in Chinese women. (PubMed id 15363546)1, 4, 9 Yang X.R....Caporaso N.E. (Cancer Lett. 2004)
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    215. Cytochrome P4501A1 polymorphism is associated with susceptibility to acute lymphoblastic leukemia in adult Mexican patients. (PubMed id 15528152)1, 4, 9 Gallegos-Arreola M.P....ZA_A+iga-GonzA!lez G.M. (amp 2004)
    216. Genetic polymorphisms and susceptibility to childhood acute lymphoblastic leukemia. (PubMed id 14991750)1, 4, 9 Canalle R....Takahashi C.S. (Environ. Mol. Mutagen. 2004)
    217. Serum polychlorinated biphenyls, cytochrome P-450 1A1 polymorphisms, and risk of breast cancer in Connecticut women. (PubMed id 15583370)1, 4, 9 Zhang Y....Zheng T. (Am. J. Epidemiol. 2004)
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    219. Xenobiotic gene polymorphisms and susceptibility to multiple myeloma. (PubMed id 15136237)1, 4, 9 Lincz L.F....Spencer A. (Haematologica 2004)
    220. Polymorphisms of CYP1A1 and glutathione S-transferase and susceptibility to adult acute myeloid leukemia. (PubMed id 15194533)1, 4, 9 D'AlA^ F....Leone G. (Haematologica 2004)
    221. Association of CYP1A1 gene polymorphism with recurrent pregnancy loss in the South Indian population. (PubMed id 15333597)1, 4, 9 Suryanarayana V....Singh L. (Hum. Reprod. 2004)
    222. The effects of diet on DNA bulky adduct levels are strongly modified by GSTM1 genotype: a study on 634 subjects. (PubMed id 14656945)1, 4, 9 Palli D....Garte S. (Carcinogenesis 2004)
    223. A polymorphism in the CYP17 gene and intrauterine fetal growth restriction. (PubMed id 14665706)1, 4, 9 Yamada H....Minakami H. (Mol. Hum. Reprod. 2004)
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    225. Vegetable, fruit and meat consumption and potential risk modifying genes in relation to colorectal cancer. (PubMed id 15352038)1, 4, 9 Turner F....Barrett J.H. (Int. J. Cancer 2004)
    226. Polymorphic variation of Cyp1A1 is associated with the risk of gastric cardia cancer: a prospective case-cohort study of cytochrome P-450 1A1 and GST enzymes. (PubMed id 15801491)1, 4, 9 Roth M.J....Qiao Y.L. (amp 2004)
    227. [A study on the inherited susceptibility of chromosomal damage in peripheral blood lymphocytes among coke oven workers]. (PubMed id 15061915)1, 4, 9 Leng S.G....He F.S. (Zhonghua Yu Fang Yi Xue Za Zhi 2004)
    228. Benzo(a)pyrene diolepoxide (BPDE)-DNA adduct levels in leukocytes of smokers in relation to polymorphism of CYP1A1, GSTM1, GSTP1, GSTT1, and mEH. (PubMed id 15298956)1, 4, 9 Lodovici M....Dolara P. (amp 2004)
    229. CYP1A1 and XRCC1 gene polymorphisms in SCC of the larynx. (PubMed id 14639127)1, 4, 9 Varzim G....Lopes C. (Eur. J. Cancer Prev. 2003)
    230. Effects of dietary habits and CYP1A1 polymorphisms on blood dioxin concentrations in Japanese men. (PubMed id 12729704)1, 4, 9 Tsuchiya Y....Yamamoto M. (Chemosphere 2003)
    231. CYP enzyme polymorphisms and susceptibility to HCV-related chronic liver disease and liver cancer. (PubMed id 12569554)1, 4, 9 Silvestri L....Silini E.M. (Int. J. Cancer 2003)
    232. Polymorphisms of drug-metabolizing enzymes CYP2C9, CYP2C19, CYP2D6, CYP1A1, NAT2 and of P-glycoprotein in a Russian population. (PubMed id 12879168)1, 4, 9 Gaikovitch E.A....Roots I. (Eur. J. Clin. Pharmacol. 2003)
    233. Genetic polymorphisms in biotransformation enzymes in Crohn's disease: association with microsomal epoxide hydrolase. (PubMed id 12631667)1, 4, 9 de Jong D.J....Naber T.H. (Gut 2003)
    234. Polymorphisms in the CYP1A1 gene are associated with prostate cancer risk. (PubMed id 12845676)1, 4, 9 Chang B.L....Xu J. (Int. J. Cancer 2003)
    235. CYP1A1*2B (Val) allele is overrepresented in a subgroup of acute myeloid leukemia patients with poor-risk karyotype associated with NRAS mutation, but not associated with FLT3 internal tandem duplication. (PubMed id 12468438)1, 4, 9 Bowen D.T....Morgan G.J. (Blood 2003)
    236. Effects of genetic polymorphisms in metabolic enzymes on the relationships between 8-hydroxydeoxyguanosine levels in human leukocytes and urinary 1-hydroxypyrene and 2-naphthol concentrations. (PubMed id 14646291)1, 4, 9 Kim Y.D....Kim H. (J Occup Health 2003)
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    238. Estrogen-metabolizing gene polymorphisms, but not estrogen receptor-alpha gene polymorphisms, are associated with the onset of menarche in healthy postmenopausal Japanese women. (PubMed id 12574216)1, 4, 9 Gorai I....Hirahara F. (J. Clin. Endocrinol. Metab. 2003)
    239. Cytochrome P450 and manganese superoxide dismutase genes polymorphisms in systemic lupus erythematosus. (PubMed id 14611903)1, 4, 9 Yen J.H....Liu H.W. (Immunol. Lett. 2003)
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    242. Analysis of polymorphic patterns in candidate genes in Israeli patients with prostate cancer. (PubMed id 14719475)1, 4, 9 Figer A....Friedman E. (Isr. Med. Assoc. J. 2003)
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    252. Susceptibility factors and DNA adducts in peripheral blood mononuclear cells of aluminium smelter workers exposed to polycyclic aromatic hydrocarbons. (PubMed id 11967624)1, 4, 9 Tuominen R....Rannug A. (Arch. Toxicol. 2002)
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    311. Pharmacogenomics of maternal tobacco use: metabolic gene polymorphisms and risk of adverse pregnancy outcomes. (PubMed id 20177288)1, 4 Aagaard-Tillery K....Wapner R.J. (Obstet Gynecol 2010)
    312. Genetic polymorphisms in cytochrome P450 genes are associated with an increased risk of squamous cell carcinoma of the larynx and hypopharynx in a Chinese population. (PubMed id 19963139)1, 4 Tai J....Han D. (Cancer Genet. Cytogenet. 2010)
    313. Hypermethylation of carcinogen metabolism genes, CYP1A1, CYP2A13 and GSTM1 genes in head and neck cancer. (PubMed id 20846153)1, 4 Sharma R....Khullar M. (Oral Dis 2010)
    314. CYP1A1, CYP1A2 and CYBA gene polymorphisms associated with oxidative stress in COPD. (PubMed id 20080081)1, 4 Vibhuti A....Pasha M.A. ( international journal of clinical chemistry 2010)
    315. The association between a functional CYP1A1 polymorphism and colorectal neoplasia risk in post menopausal women. (PubMed id 20094781)1, 4 Early D.S....Armamento-Villareal R. (Dig. Dis. Sci. 2010)
    316. Cigarette smoking, genetic variants in carcinogen-metabolizing enzymes, and colorectal cancer risk. (PubMed id 20937634)1, 4 Cleary S.P....Harper P. (Am. J. Epidemiol. 2010)
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    318. Polymorphisms in xenobiotic metabolizing enzymes and diet influence colorectal adenoma risk. (PubMed id 20375710)1, 4 Northwood E.L....Smith G. (Pharmacogenet. Genomics 2010)
    319. Candidate gene association studies and risk of childhood acute lymphoblastic leukemia: a systematic review and meta-analysis. (PubMed id 20511665)1, 4 Vijayakrishnan J. and Houlston R.S. (Haematologica 2010)
    320. Association of testicular germ cell tumor with polymorphisms in estrogen receptor and steroid metabolism genes. (PubMed id 19776291)1, 4 Ferlin A....Foresta C. (Endocr. Relat. Cancer 2010)
    321. Association of xenobiotic metabolizing enzymes genetic polymorphisms with esophageal cancer in Kashmir Valley and influence of environmental factors. (PubMed id 20661821)1, 4 Malik M.A....Mittal B. (Nutr Cancer 2010)
    322. Effect modification of endocrine disruptors and testicular germ cell tumour risk by hormone-metabolizing genes. (PubMed id 19627379)1, 4 Chia V.M....McGlynn K.A. (Int. J. Androl. 2010)
    323. The CYP1A1 Ile462Val polymorphism and platinum resistance of epithelial ovarian neoplasms. (PubMed id 20377136)1, 4 Heubner M....Siffert W. (Oncol. Res. 2010)
    324. CYP1A1 modifies the effect of maternal exposure to environmental tobacco smoke on child behavior. (PubMed id 20855412)1, 4 Hsieh C.J....Chen P.C. (amp 2010)
    325. Possible risk modification by polymorphisms of estrogen metabolizing genes in familial breast cancer susceptibility in an Indian population. (PubMed id 19863350)1, 4 Syamala V.S....Ankathil R. (Cancer Invest. 2010)
    326. Combined effects of cigarette smoking, gene polymorphisms and methylations of tumor suppressor genes on non small cell lung cancer: a hospital-based case-control study in China. (PubMed id 20704749)1, 4 Jin Y....Xue S. (BMC Cancer 2010)
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    328. Involvement of CYP1A1, GST, 72TP53 polymorphisms in the pathogenesis of thyroid nodules. (PubMed id 21086258)1, 4 Reis A.A....da Cruz A.D. (Genet. Mol. Res. 2010)
    329. Cigarette smoking, genetic polymorphisms and colorectal cancer risk: the Fukuoka Colorectal Cancer Study. (PubMed id 20534171)1, 4 Nisa H....Terasaka R. (BMC Cancer 2010)
    330. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (PLoS ONE 2010)
    331. Genetic polymorphisms in the metabolic pathway and non-Hodgkin lymphoma survival. (PubMed id 20029944)1, 4 Han X....Zhang Y. (Am. J. Hematol. 2010)
    332. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PubMed id 20453000)1, 4 Liu C.Y....Christiani D.C. (Carcinogenesis 2010)
    333. CYP1A1 gene polymorphisms as a risk factor for pterygium. (PubMed id 20596254)1, 4 Young C.H....Cheng Y.W. (Mol. Vis. 2010)
    334. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PubMed id 20734064)1, 4 He C....Hunter D.J. (Hum. Genet. 2010)
    335. Comprehensive analysis of common genetic variation in 61 genes related to steroid hormone and insulin-like growth factor-I metabolism and breast cancer risk in the NCI breast and prostate cancer cohort consortium. (PubMed id 20634197)1, 4 Canzian F....Feigelson H.S. (Hum. Mol. Genet. 2010)
    336. Smoking related risk involved in individuals carrying genetic variants of CYP1A1 gene in head and neck cancer. (PubMed id 20887941)1, 4 Sabitha K....Jamil K. (Cancer Epidemiol 2010)
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    338. CYP1A1 MSPI (T6235C) gene polymorphism is associated with mortality in acute coronary syndrome patients. (PubMed id 19650794)1, 4 Jarvis M.D....Cameron V.A. (amp 2010)
    339. Polymorphisms in metabolic genes CYP1A1 and GSTM1 and changes in maternal smoking during pregnancy. (PubMed id 19246429)1, 4 Chen X. and Woodcroft K.J. (amp 2009)
    340. Tobacco and estrogen metabolic polymorphisms and risk of non-small cell lung cancer in women. (PubMed id 19174490)1, 4 Cote M.L....Schwartz A.G. (Carcinogenesis 2009)
    341. Phase I and II enzyme polymorphisms as risk factors for Barrett's esophagus and esophageal adenocarcinoma: a systematic review and meta-analysis. (PubMed id 19222528)1, 4 Bull L.M....El-Serag H.B. (Dis. Esophagus 2009)
    342. Genetic associations of 115 polymorphisms with cancers of the upper aerodigestive tract across 10 European countries: the ARCAGE project. (PubMed id 19339270)1, 4 Canova C....Brennan P. (Cancer Res. 2009)
    343. Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. (PubMed id 19170196)1, 4 Shen M....Lan Q. (Environ. Mol. Mutagen. 2009)
    344. African American-preponderant single nucleotide polymorphisms (SNPs) and risk of breast cancer. (PubMed id 19679043)1, 4 Kato I....Korczak J.F. (Cancer Epidemiol 2009)
    345. CYP1A1 and CYP2D6 gene polymorphisms in Israeli Jewish women with cervical cancer. (PubMed id 20009880)1, 4 Gutman G....Grisaru D. (Int. J. Gynecol. Cancer 2009)
    346. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (J. Bone Miner. Res. 2009)
    347. Genetic variations in xenobiotic metabolic pathway genes, personal hair dye use, and risk of non-Hodgkin lymphoma. (PubMed id 19822571)1, 4 Zhang Y....Zheng T. (Am. J. Epidemiol. 2009)
    348. [Relationship between gene polymorphism of CYP2E1, CYP1A1, IL-4 and medicamentosa-like dermatitis induced by trichloroethylene]. (PubMed id 19351467)1, 4 Xu X.Y....Yang L.Q. (Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2009)
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    350. Genome-wide association study identifies eight loci associated with blood pressure. (PubMed id 19430483)1, 4 Newton-Cheh C....Munroe P.B. (Nat. Genet. 2009)
    351. [Role of xenobiotic biotransformation enzymes in respiratory diseases caused by dust]. (PubMed id 20095411)1, 4 Mingazova S.R....Akhmadishina L.Z. (Med Tr Prom Ekol 2009)
    352. Genetic polymorphisms of FSHR, CYP17, CYP1A1, CAPN10, INSR, SERPINE1 genes in adolescent girls with polycystic ovary syndrome. (PubMed id 19387820)1, 4 Unsal T....Menevse A. (J. Assist. Reprod. Genet. 2009)
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    354. PTEN identified as important risk factor of chronic obstructive pulmonary disease. (PubMed id 19625176)1, 4 Hosgood H.D....Lan Q. (Respir Med 2009)
    355. Candidate gene association study of esophageal squamous cell carcinoma in a high-risk region in Iran. (PubMed id 19826048)1, 4 Akbari M.R....Narod S.A. (Cancer Res. 2009)
    356. Polymorphisms of drug-metabolizing genes and risk of non-Hodgkin lymphoma. (PubMed id 19899130)1, 4 Kim H.N....Kim H.J. (Am. J. Hematol. 2009)
    357. [A case-control study of environmental and genetic factors and prostate cancer in Guangdong]. (PubMed id 19954068)1, 4 Wu Y.J....Liu Q. (Zhonghua Yu Fang Yi Xue Za Zhi 2009)
    358. Risk of malignant pleural mesothelioma and polymorphisms in genes involved in the genome stability and xenobiotics metabolism. (PubMed id 19751749)1, 4 Gemignani F....Landi S. (Mutat. Res. 2009)
    359. Coffee intake, variants in genes involved in caffeine metabolism, and the risk of epithelial ovarian cancer. (PubMed id 18941913)1, 4 Kotsopoulos J....Tworoger S.S. (amp 2009)
    360. [Relationship between genetic polymorphisms of phase I and phase II metabolizing enzymes and DNA damage of workers exposed to vinyl chloride monomer]. (PubMed id 19267064)1, 4 Ji F....Wang W. (Wei Sheng Yan Jiu 2009)
    361. Novel DNA sequence variations of cytochrome P450 genes in the Han Chinese population. (PubMed id 19290787)1, 4 Wang H.H....Chen Y.T. (Pharmacogenomics 2009)
    362. Relation of PON1 and CYP1A1 genetic polymorphisms to clinical findings in a cross-sectional study of a Greek rural population professionally exposed to pesticides. (PubMed id 19022366)1, 4 Tsatsakis A.M....Kafatos A. (Toxicol. Lett. 2009)
    363. Determination of genetic predisposition to patent ductus arteriosus in preterm infants. (PubMed id 19336370)1, 4 Dagle J.M....Murray J.C. (Pediatrics 2009)
    364. Quantitative trait loci predicting circulating sex steroid hormones in men from the NCI-Breast and Prostate Cancer Cohort Consortium (BPC3). (PubMed id 19574343)1, 4 Ahn J....Hayes R.B. (Hum. Mol. Genet. 2009)
    365. Integrative predictive model of coronary artery calcification in atherosclerosis. (PubMed id 19948975)1, 4 McGeachie M....Ramoni M.F. (Circulation 2009)
    366. Racial disparity in pathophysiologic pathways of preterm birth based on genetic variants. (PubMed id 19527514)1, 4 Menon R....Thorsen P. (amp 2009)
    367. Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PubMed id 19343046)1, 4 Saito A....Kamatani N. (J. Hum. Genet. 2009)
    368. CYP1A1/2 haplotypes and lung cancer and assessment of confounding by population stratification. (PubMed id 19276377)1, 4 Aldrich M.C....Wiencke J.K. (Cancer Res. 2009)
    369. Coffee consumption, genetic susceptibility and bladder cancer risk. (PubMed id 18798002)1, 4 Villanueva C.M....Kogevinas M. (amp 2009)
    370. Polymorphism of the CYP1A1*2A gene and susceptibility to lung cancer in a Brazilian population. (PubMed id 19750329)1, 4 Honma H.N....Zambon L. (J Bras Pneumol 2009)
    371. A gene-based risk score for lung cancer susceptibility in smokers and ex-smokers. (PubMed id 19789190)1, 4 Young R.P....Gamble G.D. (Postgrad Med J 2009)
    372. Genetic polymorphisms of cytochrome p450 and matrix metalloproteinase in chronic obstructive pulmonary disease. (PubMed id 19507017)1, 4 Cheng S.L....Yang P.C. (Biochem. Genet. 2009)
    373. Paternal smoking, genetic polymorphisms in CYP1A1 and childhood leukemia risk. (PubMed id 18691756)1, 4 Lee K.M....Kang D. (Leuk. Res. 2009)
    374. Sex steroid metabolism polymorphisms and mammographic density in pre- and early perimenopausal women. (PubMed id 19630952)1, 4 Crandall C.J....Sinsheimer J.S. (Breast Cancer Res. 2009)
    375. [The association of TCR-mutant cells with DNA polymorphism in women residing in radiation polluted regions of the Russian Federation]. (PubMed id 19799358)1, 4 Zamulaeva I.A....Rubanovich A.V. (Radiats Biol Radioecol 2009)
    376. Aromatic DNA adducts and polymorphisms in metabolic genes in healthy adults: findings from the EPIC-Spain cohort. (PubMed id 19307236)1, 4 Agudo A....GonzA!lez C.A. (Carcinogenesis 2009)
    377. Spontaneous preterm birth in African Americans is associated with infection and inflammatory response gene variants. (PubMed id 19019335)1, 4 Velez D.R....Menon R. (Am. J. Obstet. Gynecol. 2009)
    378. Prevalence in the United States of selected candidate gene variants: Third National Health and Nutrition Examination Survey, 1991-1994. (PubMed id 18936436)1, 4 Chang M.H....Khoury M.J. (Am. J. Epidemiol. 2009)
    379. Genetic polymorphisms in glutathione S-transferases and cytochrome P450s, tobacco smoking, and risk of non-Hodgkin lymphoma. (PubMed id 19338043)1, 4 Kilfoy B.A....Zhang Y. (Am. J. Hematol. 2009)
    380. CYP1A1 polymorphisms and risk of lung cancer in the ethnic Kashmiri population. (PubMed id 19827888)1, 4 Shaffi S.M....Siddiqi M.A. (Asian Pac. J. Cancer Prev. 2009)
    381. Polymorphisms of CYP1A1 and GSTM1 and laryngeal cancer risk: evidence-based meta-analyses. (PubMed id 19252926)1, 4 Zhuo W.L....Chen Z.T. (J. Cancer Res. Clin. Oncol. 2009)
    382. Relation of genetic polymorphisms in the cytochrome P450 gene with clopidogrel resistance after drug-eluting stent implantation in Koreans. (PubMed id 19576320)1, 4 Lee J.M....Jang Y. (Am. J. Cardiol. 2009)
    383. Validating genetic risk associations for ovarian cancer through the international Ovarian Cancer Association Consortium. (PubMed id 19127255)1, 4 Pearce C.L.... . (Br. J. Cancer 2009)
    384. Genes related to sex steroids, neural growth, and social-emotional behavior are associated with autistic traits, empathy, and Asperger syndrome. (PubMed id 19598235)1, 4 Chakrabarti B....Baron-Cohen S. (Autism Res 2009)
    385. Polymorphism in cytochrome P4501A1 is significantly associated with head and neck cancer risk. (PubMed id 19639480)1, 4 Singh A.P....Parmar D. (Cancer Invest. 2009)
    386. Colon tumor mutations and epigenetic changes associated with genetic polymorphism: insight into disease pathways. (PubMed id 18992263)1, 4 Slattery M.L....Samowitz W.S. (Mutat. Res. 2009)
    387. Phase I metabolic genes and risk of lung cancer: multiple polymorphisms and mRNA expression. (PubMed id 19479063)1, 4 Rotunno M....Landi M.T. (PLoS ONE 2009)
    388. CYP1A1, CYP2E1, GSTM1, GSTT1, EPHX1 exons 3 and 4, and NAT2 polymorphisms, smoking, consumption of alcohol and fruit and vegetables and risk of head and neck cancer. (PubMed id 17611777)1, 4 Boccia S....Ricciardi G. (J. Cancer Res. Clin. Oncol. 2008)
    389. Polymorphisms of selected xenobiotic genes contribute to the development of papillary thyroid cancer susceptibility in Middle Eastern population. (PubMed id 18601742)1, 4 Siraj A.K....Al-Kuraya K. (BMC Med. Genet. 2008)
    390. Relationship between genetic polymorphism of CYP1A1 at codon 462 (Ile462Val) in colorectal cancer. (PubMed id 18409146)1, 4 Pereira Serafim P.V....Manoukias Forones N. (Int. J. Biol. Markers 2008)
    391. Preterm birth in Caucasians is associated with coagulation and inflammation pathway gene variants. (PubMed id 18818748)1, 4 Velez D.R....Menon R. (PLoS ONE 2008)
    392. Bladder cancer risk and genetic variation in AKR1C3 and other metabolizing genes. (PubMed id 18632753)1, 4 Figueroa J.D....Rothman N. (Carcinogenesis 2008)
    393. Genetic variation in hormone metabolizing genes and risk of testicular germ cell tumors. (PubMed id 18415690)1, 4 Figueroa J.D....McGlynn K.A. (amp 2008)
    394. CYP1A1 Ile462Val and GSTT1 modify the effect of cord blood cotinine on neurodevelopment at 2 years of age. (PubMed id 18577398)1, 4 Hsieh C.J....Chen P.C. (Neurotoxicology 2008)
    395. Genetic susceptibilities in the association between maternal exposure to tobacco smoke and the risk of nonsyndromic oral cleft. (PubMed id 18698632)1, 4 Chevrier C....Cordier S. (Am. J. Med. Genet. A 2008)
    396. Molecular aspects of osteopathy in type 1 Gaucher disease: correlation between genetics and bone density. (PubMed id 18317771)1, 4 Arnheim E....Altarescu G. (Rheumatol. Int. 2008)
    397. Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia. (PubMed id 19074885)1, 4 Enjuanes A....Campo E. (Cancer Res. 2008)
    398. Screening of 214 single nucleotide polymorphisms in 44 candidate cancer susceptibility genes: a case-control study on gastric and colorectal cancers in the Japanese population. (PubMed id 18510611)1, 4 Ikeda S....Tsugane S. (Am. J. Gastroenterol. 2008)
    399. Effect of genetic predisposition on the risk of gallbladder cancer in Hungary. (PubMed id 18990008)1, 4 Kimura A....Nakamura K. (Asian Pac. J. Cancer Prev. 2008)
    400. Case-control study of oral and oropharyngeal cancer in whites and genetic variation in eight metabolic enzymes. (PubMed id 18642288)1, 4 Buch S.C....Romkes M. (amp 2008)
    401. Polymorphisms in genes involved in sex hormone metabolism, estrogen plus progestin hormone therapy use, and risk of postmenopausal breast cancer. (PubMed id 18628428)1, 4 Diergaarde B....White E. (amp 2008)
    402. Association of estrogen-related polymorphisms with age at menarche, age at final menstrual period, and stages of the menopausal transition. (PubMed id 17589376)1, 4 Mitchell E.S....Woods N.F. (Menopause 2008)
    403. CYP1A1 polymorphisms and the risk of upper aerodigestive tract cancers in an Indian population. (PubMed id 18767181)1, 4 Sam S.S....Chandrasekaran A. (amp 2008)
    404. Meta-analysis and pooled analysis of GSTM1 and CYP1A1 polymorphisms and oral and pharyngeal cancers: a HuGE-GSEC review. (PubMed id 18496222)1, 4 Varela-Lema L....Ragin C.C. (Genet. Med. 2008)
    405. [Associations of the genotypes of the CYP1A1 gene with predisposition to hydatid disease caused by Echinococcus granulosus strain G1]. (PubMed id 18819424)1, 4 Lukmanova G.I....Viktorova T.V. (Med Parazitol (Mosk) 2008)
    406. Maternal smoking and oral clefts: the role of detoxification pathway genes. (PubMed id 18449058)1, 4 Lie R.T....Vindenes H. (Epidemiology 2008)
    407. Passive smoking, cytochrome P450 gene polymorphisms and dysmenorrhea. (PubMed id 18437510)1, 4 Lei L....Chen D. (Eur. J. Epidemiol. 2008)
    408. Distribution of CYP1A1*2A polymorphism in adult patients with acute lymphoblastic leukemia in a Mexican population. (PubMed id 18203634)1, 4 Gallegos-Arreola M.P....ZA_A+iga-GonzA!lez G.M. (amp 2008)
    409. [Analysis of the cytochrome P450 (CYP1A1) gene polymorphism in the ethnic groups of the Republic of Bashkortostan]. (PubMed id 19178087)1, 4 Kochetova O.V....Victorova T.V. (Genetika 2008)
    410. Association of cytochrome P450, glutathione S-transferase and N-acetyl transferase 2 gene polymorphisms with incidence of acute myeloid leukemia. (PubMed id 18287869)1, 4 Majumdar S....Dasgupta U.B. (Eur. J. Cancer Prev. 2008)
    411. Red meat intake, doneness, polymorphisms in genes that encode carcinogen-metabolizing enzymes, and colorectal cancer risk. (PubMed id 18990750)1, 4 Cotterchio M....Harper P.A. (amp 2008)
    412. Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway. (PubMed id 18676680)1, 4 Hosgood H.D....Lan Q. (Carcinogenesis 2008)
    413. Polymorphisms in genes related to activation or detoxification of carcinogens might interact with smoking to increase renal cancer risk: results from The Netherlands Cohort Study on diet and cancer. (PubMed id 17982751)1, 4 Smits K.M....van den Brandt P.A. (World J Urol 2008)
    414. Assessment of interactions between PAH exposure and genetic polymorphisms on PAH-DNA adducts in African American, Dominican, and Caucasian mothers and newborns. (PubMed id 18268125)1, 4 Wang S....Perera F.P. (amp 2008)
    415. CYP1A1 *2B and *4 polymorphisms are associated with lung cancer susceptibility in Mexican patients. (PubMed id 18409147)1, 4 Gallegos-Arreola M.P....ZA_niga-GonzA!lez G.M. (Int. J. Biol. Markers 2008)
    416. Head and neck squamous-cell cancer and its association with polymorphic enzymes of xenobiotic metabolism and repair. (PubMed id 18569591)1, 4 Harth V....Ickstadt K. (J. Toxicol. Environ. Health Part A 2008)
    417. Influence of genetic factors on toluene diisocyanate-related symptoms: evidence from a cross-sectional study. (PubMed id 18447907)1, 4 Broberg K....Littorin M. (Environ Health 2008)
    418. Cytogenetic effects induced by Prestige oil on human populations: the role of polymorphisms in genes involved in metabolism and DNA repair. (PubMed id 18495522)1, 4 PAcrez-CadahA-a B....MAcndez J. (Mutat. Res. 2008)
    419. Association of CYP1A1 Msp1 polymorphism with tobacco-related risk of gallbladder cancer in a north Indian population. (PubMed id 18287863)1, 4 Pandey S.N....Mittal B. (Eur. J. Cancer Prev. 2008)
    420. Polymorphisms in the estrogen receptor 1 and vitamin C and matrix metalloproteinase gene families are associated with susceptibility to lymphoma. (PubMed id 18636124)1, 4 Skibola C.F....Smith M.T. (PLoS ONE 2008)
    421. Profile of polymorphisms of drug-metabolising enzymes and the risk of therapy-related leukaemia. (PubMed id 17367411)1, 4 Bolufer P....Sanz M.A. (Br. J. Haematol. 2007)
    422. Cytochrome P450IA1 polymorphisms along with PM(10) exposure contribute to the risk of birth weight reduction. (PubMed id 17706398)1, 4 Suh Y.J....Ha E.H. (Reprod. Toxicol. 2007)
    423. Genetic susceptibility according to three metabolic pathways in cancers of the lung and bladder and in myeloid leukemias in nonsmokers. (PubMed id 17496311)1, 4 Vineis P....Autrup H. (Ann. Oncol. 2007)
    424. Polymorphisms of the COL1A2, CYP1A1 and HS1,2 Ig enhancer genes in the Tuaregs from Libya. (PubMed id 17620151)1, 4 Martinez-Labarga C....Rickards O. (Ann. Hum. Biol. 2007)
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    426. CYP1A1 and GSTM1/T1 genetic variation in predicting risk for cerebral infarction. (PubMed id 17873299)1, 4 Moon K.S....Um J.Y. (J. Mol. Neurosci. 2007)
    427. PAH-DNA adducts in environmentally exposed population in relation to metabolic and DNA repair gene polymorphisms. (PubMed id 17412371)1, 4 Binkova B....Sram R.J. (Mutat. Res. 2007)
    428. Multi-factor dimensionality reduction applied to a large prospective investigation on gene-gene and gene-environment interactions. (PubMed id 16956909)1, 4 Manuguerra M....Vineis P. (Carcinogenesis 2007)
    429. Polymorphisms of cytochrome P450 1A1, glutathione S-transferase class mu, and tumour protein p53 genes and the risk of developing gallbladder cancer in Japanese. (PubMed id 17531965)1, 4 Tsuchiya Y....Yamamoto M. (Clin. Biochem. 2007)
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    431. CYP17 and COMT gene polymorphisms can influence bone directly, or indirectly through their effects on endogenous sex steroids, in postmenopausal Japanese women. (PubMed id 16971197)1, 4 Gorai I....Chaki O. (Bone 2007)
    432. The influence of metabolic gene polymorphisms on urinary 1-hydroxypyrene concentrations in Chinese coke oven workers. (PubMed id 17498780)1, 4 Chen B....Zhou Y. (Sci. Total Environ. 2007)
    433. Ovarian cancer risk and polymorphisms involved in estrogen catabolism. (PubMed id 17372243)1, 4 Holt S.K....Chen C. (amp 2007)
    434. Polymorphisms in metabolic genes, their combination and interaction with tobacco smoke and alcohol consumption and risk of gastric cancer: a case-control study in an Italian population. (PubMed id 17996038)1, 4 Boccia S....Ricciardi G. (BMC Cancer 2007)
    435. The influence of genetic polymorphisms in Ahr, CYP1A1, CYP1A2, CYP1B1, GST M1, GST T1 and UGT1A1 on urine 1-hydroxypyrene glucuronide concentrations in healthy subjects from Rio Grande do Sul, Brazil. (PubMed id 16864595)1, 4 Abnet C.C....Dawsey S.M. (Carcinogenesis 2007)
    436. Passive smoking, metabolic gene polymorphisms, and infant birth weight in a prospective cohort study of Chinese women. (PubMed id 17526865)1, 4 Wu T....Chen D. (Am. J. Epidemiol. 2007)
    437. Interaction between cytochrome P450 gene polymorphisms and serum organochlorine TEQ levels in the risk of endometriosis. (PubMed id 17449539)1, 4 Tsuchiya M....Tsugane S. (Mol. Hum. Reprod. 2007)
    438. The GST deletions and NQO1*2 polymorphism confers interindividual variability of response to treatment in patients with acute myeloid leukemia. (PubMed id 17118447)1, 4 Barragan E....Sanz M.A. (Leuk. Res. 2007)
    439. CYP1A1 gene polymorphisms in modifying the association between passive smoking and primary dysmenorrhea. (PubMed id 17728147)1, 4 Li N....Chen D. (Ann Epidemiol 2007)
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    441. Associations among genetic susceptibility, DNA damage, and pregnancy outcomes of expectant mothers exposed to environmental tobacco smoke. (PubMed id 17610937)1, 4 Wu F.Y....Lai J.S. (Sci. Total Environ. 2007)
    442. Impact of air pollution and genotype variability on DNA damage in Prague policemen. (PubMed id 17590289)1, 4 Novotna B....Sram R.J. (Toxicol. Lett. 2007)
    443. Glutathione-S-transferase M1 and T1 and cytochrome P1A1 genetic polymorphisms and susceptibility to cervical intraepithelial neoplasia in Greek women. (PubMed id 18090121)1, 4 Agorastos T....Bontis J.N. (Eur. J. Cancer Prev. 2007)
    444. Associations between smoking, polymorphisms in polycyclic aromatic hydrocarbon (PAH) metabolism and conjugation genes and PAH-DNA adducts in prostate tumors differ by race. (PubMed id 17548691)1, 4 Nock N.L....Rybicki B.A. (amp 2007)
    445. CYP1A1 Msp1 T/C polymorphism in esophageal cancer: no association and risk modulation. (PubMed id 18074679)1, 4 Jain M....Mittal B. (Oncol. Res. 2007)
    446. Association between allelic polymorphisms of metabolizing enzymes (CYP 1A1, CYP 1A2, CYP 2E1, mEH) and occurrence of colorectal cancer in Hungary. (PubMed id 17695473)1, 4 Kiss I....Ember I. (Anticancer Res. 2007)
    447. Evidence of gene gene interactions in lung carcinogenesis in a large pooled analysis. (PubMed id 17307802)1, 4 Vineis P....Taioli E. (Carcinogenesis 2007)
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    449. Polymorphisms in metabolic genes related to tobacco smoke and the risk of gastric cancer in the European prospective investigation into cancer and nutrition. (PubMed id 17164366)1, 4 Agudo A....GonzA!lez C.A. (amp 2006)
    450. Nicotine metabolizing genes GSTT1 and CYP1A1 in sudden infant death syndrome. (PubMed id 16763966)1, 4 Rand C.M....Berry-Kravis E.M. (Am. J. Med. Genet. A 2006)
    451. Polymorphisms in the estrogen synthesis and metabolism pathways and symptoms during the menopausal transition: observations from the Seattle Midlife Women's Health Study. (PubMed id 16977255)1, 4 Woods N.F....Farin F.M. (Menopause 2006)
    452. Cytochrome P2A13 and P1A1 gene polymorphisms are associated with the occurrence of uterine leiomyoma. (PubMed id 16835796)1, 4 Herr D....Pietrowski D. (Arch. Gynecol. Obstet. 2006)
    453. Comparison of polymorphisms in genes involved in polycyclic aromatic hydrocarbon metabolism with urinary phenanthrene metabolite ratios in smokers. (PubMed id 17035385)1, 4 Hecht S.S....Hatsukami D.K. (amp 2006)
    454. Genetic polymorphisms of CYP1A1, CYP2E1, GSTM1, and GSTT1 associated with head and neck cancer. (PubMed id 16721740)1, 4 GattA!s G.J....WA1nsch-Filho V. (amp 2006)
    455. Smoking and susceptibility to thyroid cancer: an inverse association with CYP1A1 allelic variants. (PubMed id 17158763)1, 4 Bufalo N.E....Ward L.S. (Endocr. Relat. Cancer 2006)
    456. CYP1A1 gene polymorphism as a risk factor for cervical intraepithelial neoplasia and invasive cervical cancer. (PubMed id 16403567)1, 4 Taskiran C....Ayhan A. (Gynecol. Oncol. 2006)
    457. [Polymorphism of CYP1A1 gene Msp I site in the Mongolian and Han nationality populations of Inner Mongolia of China]. (PubMed id 16767678)1, 4 Chang F.H. and Hu T.M. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2006)
    458. Metabolic genotypes as modulators of asbestos-related pleural malignant mesothelioma risk: a comparison of Finnish and Italian populations. (PubMed id 16697254)1, 4 Neri M....Garte S. (Int J Hyg Environ Health 2006)
    459. Association of DNA adducts and genotypes with birth weight. (PubMed id 16837240)1, 4 Sram R.J....Topinka J. (Mutat. Res. 2006)
    460. Colorectal cancer and genetic polymorphisms of CYP1A1, GSTM1 and GSTT1: a case-control study in the Grampian region of Scotland. (PubMed id 16823842)1, 4 Little J....Cassidy J. (Int. J. Cancer 2006)
    461. Multilocus genotypes spanning estrogen metabolism associated with breast cancer and fibroadenoma. (PubMed id 16608396)1, 4 Corder E.H. and Hefler L.A. (Rejuvenation Res 2006)
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    463. Polymorphisms in polycyclic aromatic hydrocarbon metabolism and conjugation genes, interactions with smoking and prostate cancer risk. (PubMed id 16614120)1, 4 Nock N.L....Witte J.S. (amp 2006)
    464. Genetic polymorphisms in xenobiotic clearance genes and their influence on disease expression in hereditary nonpolyposis colorectal cancer patients. (PubMed id 17119063)1, 4 Talseth B.A....Scott R.J. (amp 2006)
    465. Interaction between CYP1A1 T3801C and AHR G1661A polymorphisms according to smoking status on blood pressure in the Stanislas cohort. (PubMed id 17053541)1, 4 Gambier N....Visvikis-Siest S. (J. Hypertens. 2006)
    466. Joint effects of the CYP1A1 MspI, ERalpha PvuII, and ERalpha XbaI polymorphisms on the risk of breast cancer: results from a population-based case-control study in Shanghai, China. (PubMed id 16492926)1, 4 Shen Y....Gao E. (amp 2006)
    467. CYP1A1 and CYP1B1 polymorphisms and their association with estradiol and estrogen metabolites in women who are premenopausal and perimenopausal. (PubMed id 16949388)1, 4 Sowers M.R....McConnell D.S. (Am. J. Med. 2006)
    468. Estrogen sulfation genes, hormone replacement therapy, and endometrial cancer risk. (PubMed id 16985250)1, 4 Rebbeck T.R....Strom B.L. (J. Natl. Cancer Inst. 2006)
    469. Pharmacogenetic screening for polymorphisms in drug-metabolizing enzymes and drug transporters in a Dutch population. (PubMed id 16771603)1, 4 Bosch T.M....Beijnen J.H. (amp 2006)
    470. CYP1A1 and GSTP1 polymorphisms in an oral cancer case-control study. (PubMed id 17160265)1, 4 Leichsenring A....Ribeiro E.M. (Braz. J. Med. Biol. Res. 2006)
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    472. The CYP1A1 genotype may alter the association of meat consumption patterns and preparation with the risk of colorectal cancer in men and women. (PubMed id 15671210)1, 4 Murtaugh M.A....Slattery M.L. (J. Nutr. 2005)
    473. Ten estrogen-related polymorphisms and endometriosis: a study of multiple gene-gene interactions. (PubMed id 16260521)1, 4 Huber A....Tempfer C.B. (Obstet Gynecol 2005)
    474. Metabolic gene polymorphisms and lung cancer risk in non-smokers. An update of the GSEC study. (PubMed id 16009381)1, 4 Raimondi S....Taioli E. (Mutat. Res. 2005)
    475. Estrogen-metabolizing gene polymorphisms and lipid levels in women with different hormonal status. (PubMed id 16130011)1, 4 Almeida S....Hutz M.H. (Pharmacogenomics J. 2005)
    476. Cytochrome P4501A1 and glutathione S transferase gene polymorphisms in patients with aplastic anemia in India. (PubMed id 16227674)1, 4 Poonkuzhali B....Chandy M. (Acta Haematol. 2005)
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    478. Interactions between CYP1A1 polymorphisms and exposure to environmental tobacco smoke in the modulation of lymphocyte bulky DNA adducts and chromosomal aberrations. (PubMed id 15459023)1, 4 Georgiadis P....Kyrtopoulos S.A. (Carcinogenesis 2005)
    479. Estrogen metabolizing polymorphisms and breast cancer risk among older white women. (PubMed id 16142442)1, 4 Modugno F....Cauley J.A. (Breast Cancer Res. Treat. 2005)
    480. Association of genetic polymorphisms with serum estrogens measured multiple times during a 2-year period in premenopausal women. (PubMed id 15941966)1, 4 Lurie G....Le Marchand L. (amp 2005)
    481. Estrogen-metabolizing gene COMT polymorphism synergistic APOE epsilon4 allele increases the risk of Alzheimer disease. (PubMed id 15591802)1, 4 Wang P.N....Chi C.W. (Dement Geriatr Cogn Disord 2005)
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    483. Cytochrome P4501A1 polymorphisms in the Amerindian and Mestizo populations of Mexico. (PubMed id 15376230)1, 4 Fragoso J.M....Vargas-AlarcA^n G. (Cell Biochem. Funct. 2005)
    484. Phase I/II enzyme gene polymorphisms and esophageal cancer risk: a meta-analysis of the literature. (PubMed id 15849806)1, 4 Yang C.X....Tajima K. (World J. Gastroenterol. 2005)
    485. Polymorphism of CYPIA1 and GSTM1 genes associated with susceptibility of gastric cancer in Shandong Province of China. (PubMed id 16270381)1, 4 Li H....Li H.Q. (World J. Gastroenterol. 2005)
    486. CYP1A1 Val462 and NQO1 Ser187 polymorphisms, cigarette use, and risk for colorectal adenoma. (PubMed id 15731166)1, 4 Hou L....Hayes R.B. (Carcinogenesis 2005)
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    489. Analysis of the AhR, ARNT, and AhRR gene polymorphisms: genetic contribution to endometriosis susceptibility and severity. (PubMed id 16084889)1, 4 Tsuchiya M.... Ikenoue T. (Fertil. Steril. 2005)
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    492. Estrogen-metabolizing gene polymorphisms and age at natural menopause in Caucasian women. (PubMed id 15774541)1, 4 Hefler L.A....Tempfer C.B. (Hum. Reprod. 2005)
    493. Smoking habit and genetic factors associated with lung cancer in a population highly exposed to arsenic. (PubMed id 16099114)1, 4 Adonis M....Gil L. (Toxicol. Lett. 2005)
    494. Association study of detoxification genes in age related macular degeneration. (PubMed id 15774926)1, 4 Esfandiary H....Hughes A.E. (Br J Ophthalmol 2005)
    495. CYP1A1 and CYP1B1 polymorphisms and risk of lung cancer among never smokers: a population-based study. (PubMed id 16051642)1, 4 Wenzlaff A.S....Schwartz A.G. (Carcinogenesis 2005)
    496. Genetic polymorphisms and the effect of cigarette smoking in the comet assay. (PubMed id 16037119)1, 4 Hoffmann H....Speit G. (Mutagenesis 2005)
    497. Genetic factors in catechol estrogen metabolism in relation to the risk of endometrial cancer. (PubMed id 15734958)1, 4 Doherty J.A....Chen C. (amp 2005)
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    501. Metabolic polymorphisms, smoking, and oral cancer in Puerto Rico. (PubMed id 15206494)1, 4 Xie H....Hayes R.B. (Oncol. Res. 2004)
    502. Polymorphisms in glutathione S-transferases GSTM1, GSTT1 and GSTP1 and cytochromes P450 CYP2E1 and CYP1A1 and susceptibility to cirrhosis or pancreatitis in alcoholics. (PubMed id 15215328)1, 4 Burim R.V....Takahashi C.S. (Mutagenesis 2004)
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    504. Estrogen-metabolizing gene polymorphisms in the assessment of breast carcinoma risk and fibroadenoma risk in Caucasian women. (PubMed id 15241822)1, 4 Hefler L.A....Koelbl H. (Cancer 2004)
    505. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    506. Chromosome and DNA damage analysis in individuals occupationally exposed to pesticides with relation to genetic polymorphism for CYP 1A1 gene in Ecuador. (PubMed id 15279831)1, 4 Paz-y-MiA+o C....Leone P.E. (Mutat. Res. 2004)
    507. GSTM1, GSTT1, GSTP1 and CYP1A1 genetic polymorphisms and susceptibility to esophageal cancer in a French population: different pattern of squamous cell carcinoma and adenocarcinoma. (PubMed id 15526353)1, 4 Abbas A....Sichel F. (World J. Gastroenterol. 2004)
    508. Genetic variation in eleven phase I drug metabolism genes in an ethnically diverse population. (PubMed id 15469410)1, 2 Solus J.F.... Dawson E.P. (Pharmacogenomics 2004)
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    510. Impact of phase I or phase II enzyme polymorphisms on lymphocyte DNA adducts in subjects exposed to urban air pollution and environmental tobacco smoke. (PubMed id 15093273)1, 4 Georgiadis P....Kyrtopoulos S.A. (Toxicol. Lett. 2004)
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    512. Polymorphisms of estrogen-metabolizing genes and risk of hepatocellular carcinoma in Taiwan females. (PubMed id 15341023)1, 4 Yin P.H....Chi C.W. (Cancer Lett. 2004)
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    514. Polymorphisms in genes coding for enzymes metabolizing smoking-derived substances and the risk of periodontitis. (PubMed id 15491310)1, 4 Kim J.S....Park K.K. (J. Clin. Periodontol. 2004)
    515. Cytochrome p450 1Al gene polymorphisms in patients with psoriatic arthritis. (PubMed id 15124938)1, 4 Yen J.H....Liu H.W. (Scand. J. Rheumatol. 2004)
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    521. Influence of CYP1A1, GSTM1, GSTT1, and NQO1 genotypes and cumulative smoking dose on lung cancer risk in a Swedish population. (PubMed id 15184245)1, 4 Alexandrie A.K....Rannug A. (amp 2004)
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    526. Cytochrome P450 1A1 and manganese superoxide dismutase genes polymorphisms in ankylosing spondylitis. (PubMed id 12880680)1, 4 Yen J.H....Liu H.W. (Immunol. Lett. 2003)
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    533. A study to survey susceptible genetic factors responsible for troglitazone-associated hepatotoxicity in Japanese patients with type 2 diabetes mellitus. (PubMed id 12732844)1, 4 Watanabe I....Koga T. (Clin. Pharmacol. Ther. 2003)
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    536. CYP1A1 and CYP2D6 polymorphism and risk of lung cancer in a North Indian population. (PubMed id 14602525)1, 4 Sobti R.C....Janmeja A. (Biomarkers 2003)
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    559. Relationship between glutathione S-transferase M1, P1 and T1 polymorphisms and early onset prostate cancer. (PubMed id 11434510)1, 4 Kote-Jarai Z....Eeles R. (Pharmacogenetics 2001)
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    564. CYP1A1, GSTM1, and GSTT1 polymorphisms and the risk of cervical squamous intraepithelial lesions in a multiethnic population. (PubMed id 11330960)1, 4 Goodman M.T....Le Marchand L. (Gynecol. Oncol. 2001)
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    695. Hypoxia perturbs aryl hydrocarbon receptor signaling and CYP1A1 expression induced by PCB 126 in human skin and liver-derived cell lines. (PubMed id 24355420)1 Vorrink S.U....Domann F.E. (Toxicol. Appl. Pharmacol. 2013)
    696. Association of gene polymorphism in detoxification enzymes and urinary 8-OHdG levels in traffic policemen exposed to vehicular exhaust. (PubMed id 23293967)1 Prasad S.B....Prasad H.M. (Inhal Toxicol 2013)
    697. Genetic association of aromatic hydrocarbon receptor (AHR) and cytochrome P450, family 1, subfamily A, polypeptide 1 (CYP1A1) polymorphisms with dioxin blood concentrations among pregnant Japanese women. (PubMed id 23528250)1 Kobayashi S....Kishi R. (Toxicol. Lett. 2013)
    698. Association of CYP1A1 gene polymorphism with chronic kidney disease: a case control study. (PubMed id 23619522)1 Siddarth M....Tripathi A.K. (Environ. Toxicol. Pharmacol. 2013)
    699. Cytochrome P450 1A1, 2E1 and GSTM1 gene polymorphisms and susceptibility to colorectal cancer in the Saudi population. (PubMed id 23886179)1 Saeed H.M....Arafaha M. (Asian Pac. J. Cancer Prev. 2013)
    700. Quantitative assessment of the association between CYP1A1 A4889G polymorphism and endometrial cancer risk. (PubMed id 23860774)1 Li M....Wang H.B. (Tumour Biol. 2013)
    701. CYP2A6, CYP1A1, and CYP2D6 polymorphisms in lung cancer patients from central south China. (PubMed id 23471717)1 Huang F.M....Zhang D.Z. (Med. Oncol. 2013)
    702. Association between cytochrome P450 1A1 MspI polymorphism and endometrial cancer risk: a meta-analysis. (PubMed id 23918309)1 Han L....Li C. (Tumour Biol. 2013)
    703. Lack of association between CYP1A1 T6235C polymorphism and coronary artery disease: evidence from a meta-analysis. (PubMed id 23229202)1 Zhang J....Zhang X. (Mol Med Rep 2013)
    704. Cytochrome P450 1A1 (CYP1A1) gene polymorphisms and ovarian cancer risk: a meta-analysis. (PubMed id 22733497)1 Sergentanis T.N....Vlahos N.F. (Mol. Biol. Rep. 2012)
    705. Breast cancer risk, fungicide exposure and CYP1A1*2A gene-environment interactions in a province-wide case control study in Prince Edward Island, Canada. (PubMed id 22754477)1 Ashley-Martin J....Guernsey J.R. (Int J Environ Res Public Health 2012)
    706. Genetic polymorphism of estrogen metabolizing enzymes in Siberian women with breast cancer. (PubMed id 21977969)1 Khvostova E.P....Gulyaeva L.F. (Genet Test Mol Biomarkers 2012)
    707. Analysis of GSTM1, GSTT1, and CYP1A1 in idiopathic male infertility. (PubMed id 21775774)1 Salehi Z....Madani A.H. (Reprod Sci 2012)
    708. Validation of PCR-RFLP techniques for the evaluation of codon 72 of p53 and CYP1A1 gene's polymorphisms in relation with ovarian cancer in a Romanian population. (PubMed id 22395499)1 Matei M.C....AzoicA8i D. (Rom J Morphol Embryol 2012)
    709. CYP1A1 is a target of miR-892a-mediated post-transcriptional repression. (PubMed id 22470100)1 Choi Y.M....Bae S. (Int. J. Oncol. 2012)
    710. Quercetin, quercetin glycosides and taxifolin differ in their ability to induce AhR activation and CYP1A1 expression in HepG2 cells. (PubMed id 22422552)1 Vrba J....Ulrichova J. (Phytother Res 2012)
    711. Risk factor for clear cell renal cell carcinoma in Chinese population: a case-control study. (PubMed id 22000673)1 Wang G....Cao G. (Cancer Epidemiol 2012)
    712. Down-regulation of CYP1A1 expression in breast cancer. (PubMed id 22901117)1 Hafeez S....Kayani M.A. (Asian Pac. J. Cancer Prev. 2012)
    713. CYP1A1 Ile462Val polymorphism and cervical cancer: evidence from a meta-analysis. (PubMed id 22948778)1 Yang S....Han S. (Tumour Biol. 2012)
    714. The effect of CYP1A1, GSTT1 and GSTM1 polymorphisms on the risk of lung cancer: a case-control study. (PubMed id 22893352)1 Atinkaya C....Sunguroglu A. (amp 2012)
    715. The relationship among IL-13, GSTP1, and CYP1A1 polymorphisms and environmental tobacco smoke in a population of children with asthma in Northern Mexico. (PubMed id 22236719)1 MuA+oz B....Albores A. (Environ. Toxicol. Pharmacol. 2012)
    716. Lack of association of CYP1A1-MspI SNP and GSTM1 null genotypes with cancer in a Brazilian family with unusually high cancer incidence. (PubMed id 22782580)1 Moraes L.N....Souza I.L. (Genet. Mol. Res. 2012)
    717. Does cytochrome P450 1A1 MspI polymorphism increase acute lymphoblastic leukemia risk? Evidence from 2013 cases and 2903 controls. (PubMed id 22964275)1 Zhuo W....Chen Z. (Gene 2012)
    718. Association between CYP1A1 Ile462Val variation and acute leukemia risk: meta-analyses including 2164 cases and 4160 controls. (PubMed id 23056546)1 Zhuo W....Chen Z. (PLoS ONE 2012)
    719. Common polymorphisms in CYP1A1, GSTM1, GSTT1, GSTP1 and XPD genes and endogenous DNA damage. (PubMed id 22183307)1 Wlodarczyk M. and Nowicka G. (Mol. Biol. Rep. 2012)
    720. Interactions between CYP1A1 polymorphisms and cigarette smoking are associated with the risk of hepatocellular carcinoma: evidence from epidemiological studies. (PubMed id 22297691)1 Yu L....Zhu L.Y. (Mol. Biol. Rep. 2012)
    721. Carnosol, a constituent of Zyflamend, inhibits aryl hydrocarbon receptor-mediated activation of CYP1A1 and CYP1B1 transcription and mutagenesis. (PubMed id 22374940)1 Mohebati A....Dannenberg A.J. (Cancer Prev Res (Phila) 2012)
    722. Quantitative assessment of CYP1A1*2A variations with oral carcinoma susceptibility: evidence from 1,438 cases and 2,086 controls. (PubMed id 22909097)1 Zhuo X....Tan Y. (Cancer Invest. 2012)
    723. Cytochrome P450 1A1 (CYP1A1) gene polymorphisms and cervical cancer risk: a meta-analysis. (PubMed id 22294106)1 Sergentanis T.N....Vlahos N.F. (Mol. Biol. Rep. 2012)
    724. TLR2 controls intestinal carcinogen detoxication by CYP1A1. (PubMed id 22442665)1 Do K.N....Parlesak A. (PLoS ONE 2012)
    725. Risk modification by CYP1A1 and GSTM1 polymorphisms in the association of cigarette smoking and systemic lupus erythematosus in a Japanese population. (PubMed id 22217397)1 Kiyohara C....Tada Y. (Scand. J. Rheumatol. 2012)
    726. CYP1A1 Ile462Val polymorphism contributes to lung cancer susceptibility among lung squamous carcinoma and smokers: a meta-analysis. (PubMed id 22952673)1 Ji Y.N....Suo L.J. (PLoS ONE 2012)
    727. CYP1A1 MspI polymorphisms and lung cancer risk: an updated meta-analysis involving 20,209 subjects. (PubMed id 22579698)1 Ji Y.N....Suo L.J. (Cytokine 2012)
    728. Lack of association between the CYP1A1 Ile462Val polymorphism and endometrial cancer risk: a meta-analysis. (PubMed id 23098461)1 Wang X.W....Liu Q.Y. (Asian Pac. J. Cancer Prev. 2012)
    729. Preferred binding orientations of phenacetin in CYP1A1 and CYP1A2 are associated with isoform-selective metabolism. (PubMed id 22949628)1 Huang Q....Szklarz G.D. (Drug Metab. Dispos. 2012)
    730. Role of CYP1A1 haplotypes in modulating susceptibility to coronary artery disease. (PubMed id 23259321)1 Lakshmi S.V....Kutala V.K. (amp 2012)
    731. Association of CYP1A1, GSTM1, and GSTT1 gene polymorphism with risk of oral submucous fibrosis in a section of North Indian population. (PubMed id 22752755)1 Ghosh T....Agrawal D. (Mol. Biol. Rep. 2012)
    732. [Effects of CYP1A1 and GSTM1 gene polymorphisms and BPDE-DNA adducts on lung cancer]. (PubMed id 22311486)1 Chen C.M....Sun X.Y. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2012)
    733. Quantitative assessment of the associations between CYP1A1 polymorphisms and gastric cancer risk. (PubMed id 22359202)1 Guo R. and Guo X. (Tumour Biol. 2012)
    734. CYP1A1 Ile462Val is a risk factor for ovarian cancer development. (PubMed id 22277800)1 Huang M....Liu C. (Cytokine 2012)
    735. Impact of genetic variations of the CYP1A1, GSTT1, and GSTM1 genes on the risk of coronary artery disease. (PubMed id 21848428)1 Taspinar M....Sunguroglu A. (DNA Cell Biol. 2012)
    736. Theoretical investigation of differences in nitroreduction of aristolochic acid I by cytochromes P450 1A1, 1A2 and 1B1. (PubMed id 23353840)1 Jerabek P....Stiborova M. (Neuro Endocrinol. Lett. 2012)
    737. Effects of cytochrome P450 1A1 and uridine-diphosphate-glucuronosyltransferase 1A1 allelic polymorphisms on the risk of development and the prognosis of head and neck cancers. (PubMed id 22273851)1 Szanyi I....Kiss I. (Eur. J. Cancer Prev. 2012)
    738. Bioactivation versus detoxication of the urothelial carcinogen aristolochic acid I by human cytochrome P450 1A1 and 1A2. (PubMed id 22086975)1 StiborovA! M....Arlt V.M. (Toxicol. Sci. 2012)
    739. CYP1A1 protein activity is associated with allelic variation in pterygium tissues and cells. (PubMed id 22876118)1 Peng M.L....Cheng Y.W. (Mol. Vis. 2012)
    740. Association of CYP1A1 polymorphisms with prostate cancer risk: an updated meta-analysis. (PubMed id 23065259)1 Li H....He T. (Mol. Biol. Rep. 2012)
    741. Associations between polymorphisms in the AHR and CYP1A1-CYP1A2 gene regions and habitual caffeine consumption. (PubMed id 22854411)1 Josse A.R....El-Sohemy A. (Am. J. Clin. Nutr. 2012)
    742. Cytochrome 1A1 and 1B1 gene diversity in the Zanzibar islands. (PubMed id 22594779)1 Cavaco I....Gil J.P. (amp 2012)
    743. CYP1A1 gene polymorphisms: modulator of genetic damage in coal-tar workers. (PubMed id 22994769)1 Giri S.K....Gautam S.K. (Asian Pac. J. Cancer Prev. 2012)
    744. Interaction between maternal passive smoking during pregnancy and CYP1A1 and GSTs polymorphisms on spontaneous preterm delivery. (PubMed id 23152866)1 Luo Y.J....Chen W.Q. (PLoS ONE 2012)
    745. Genetic polymorphism of drug metabolizing enzymes (GSTM1 and CYP1A1) as risk factors for oral premalignant lesions and oral cancer. (PubMed id 22660220)1 Shukla D....Venkatakanthaiah Y. (Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2012)
    746. [Association between genetic polymorphism of metabolizing enzymes and DNA repairing enzymes and the susceptibility of lung cancer in Henan population]. (PubMed id 22611936)1 Wang N....Wu Y. (Wei Sheng Yan Jiu 2012)
    747. Inhibition of cytochrome P4501-dependent clearance of the endogenous agonist FICZ as a mechanism for activation of the aryl hydrocarbon receptor. (PubMed id 22392998)1 Wincent E....Rannug A. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    748. Polymorphisms of the CYP1A1 and CYP2E1 genes in head and neck squamous cell carcinoma risk. (PubMed id 21590276)1 Cury N.M....Goloni-Bertollo E.M. (Mol. Biol. Rep. 2012)
    749. Meta-analysis of the association of CYP1A1 polymorphisms with gastric cancer susceptibility and interaction with tobacco smoking. (PubMed id 22707145)1 Han F....Li W. (Mol. Biol. Rep. 2012)
    750. Vitamin D receptor activation enhances benzo[a]pyrene metabolism via CYP1A1 expression in macrophages. (PubMed id 22837390)1 Matsunawa M....Makishima M. (Drug Metab. Dispos. 2012)
    751. [LOH and genetic polymorphysms of breast cancer]. (PubMed id 23350368)1 Utsumi T. (Nippon Rinsho 2012)
    752. Associations between CYP1A1 and CYP2E1 polymorphisms and susceptibility to esophageal cancer in Chaoshan and Taihang areas of China. (PubMed id 22088806)1 Wang D....Zhang J. (Cancer Epidemiol 2012)
    753. Genetic polymorphisms in CYP1A1, GSTM1, GSTP1 and GSTT1 metabolic genes and risk of lung cancer in Asturias. (PubMed id 23013535)1 LA^pez-Cima M.F....TardA^n A. (BMC Cancer 2012)
    754. CYP1A1 MspI polymorphism and acute myeloid leukemia risk: meta-analyses based on 5018 subjects. (PubMed id 22846179)1 Zhuo W....Chen Z. (amp 2012)
    755. [Association of polymorph variants of CYP1A2 and CYP1A1 genes with reproductive and thyroid diseases in female workers of petrochemical industry]. (PubMed id 22855999)1 Irmiakova A.R....Viktorova T.V. (Med Tr Prom Ekol 2012)
    756. DNA methylation of the CYP1A1 enhancer is associated with smoking-induced genetic alterations in human lung. (PubMed id 22213191)1 Tekpli X....Mollerup S. (Int. J. Cancer 2012)
    757. Association between CYP1A1 polymorphism and colorectal cancer risk: a meta-analysis. (PubMed id 21710246)1 Zheng Y....Li H.L. (Mol. Biol. Rep. 2012)
    758. CYP1AI, glutathione S-transferase gene polymorphisms and risk of Polycythemia vera. (PubMed id 22018952)1 Naffa R.G....Ismail S.I. (Cancer Epidemiol 2012)
    759. Polymorphisms in GSTM1, CYP1A1, CYP2E1, and CYP2D6 are associated with susceptibility and chemotherapy response in non-small-cell lung cancer patients. (PubMed id 22109568)1 Li W....Gu M. (Lung 2012)
    760. [Chronic inflammatory and dystrophic diseases of the eye anterior segment and their association with genetic polymorphisms in workers of metallurgic industry]. (PubMed id 22997752)1 Mel'nichenko M.A....Zabelin V.I. (Med Tr Prom Ekol 2012)
    761. Lack of association of CYP1A1 polymorphism with prostate cancer susceptibility of Tunisian men. (PubMed id 22304463)1 Souiden Y....Mahdouani K. (Genet Test Mol Biomarkers 2012)
    762. Maternal obesity alters feto-placental cytochrome P4501A1 activity. (PubMed id 23046808)1 DuBois B.N....Cherala G. (Placenta 2012)
    763. Cytochrome P450 1A1 Ile462Val polymorphism and oral carcinoma risk: an updated meta-analysis including 1,515 cases and 2,233 controls. (PubMed id 22847262)1 Zhuo X....Tan Y. (Tumour Biol. 2012)
    764. Identification of human cytochrome P450 and flavin-containing monooxygenase enzymes involved in the metabolism of lorcaserin, a novel selective human 5-hydroxytryptamine 2C agonist. (PubMed id 22266842)7 Usmani K.A....Sadeque A.J. (Drug Metab. Dispos. 2012)
    765. Polymorphisms in CYP1A1 and ethnic-specific susceptibility to acute lymphoblastic leukemia in children. (PubMed id 21586621)1 Swinney R.M....Tomlinson G.E. (amp 2011)
    766. [The role of mutation of gene cyp1A1 and benzapilene in cytogenetic changes of urinary tract epitheliocytes in oil industry workers employed in the oil fields of the North of West Siberia]. (PubMed id 22448487)1 Il'inskikh N.N....Iamkovaia E.V. (Urologiia 2011)
    767. Induction of cytochromes P450 1A1 and 1A2 by tanshinones in human HepG2 hepatoma cell line. (PubMed id 21262253)1 Zhang R....Wang G. (Toxicol. Appl. Pharmacol. 2011)
    768. CYP1A1 polymorphism in adolescents with polycystic ovary syndrome. (PubMed id 20965504)1 AkgA1l S....AktaA9 D. (Int J Gynaecol Obstet 2011)
    769. Inhibition of 17I^-estradiol activation by CYP1A1: genotype- and regioselective inhibition by St. John's Wort and several natural polyphenols. (PubMed id 20883830)1 Schwarz D....Roots I. (Biochim. Biophys. Acta 2011)
    770. Evaluation of the influence of polymorphic variants CYP1A1 2B, CYP1B1 2, CYP3A4 1B, GSTM1 0, and GSTT1 0 in prostate cancer. (PubMed id 20884258)1 Rodrigues I.S....de Syllos CA^lus I.M. (Urol. Oncol. 2011)
    771. [CYP1A1 gene and GSTM1 gene polymorphism and the combined effects and risk of lung cancer: a meta-analysis]. (PubMed id 21859547)1 Li C....Zhou B. (Zhongguo Fei Ai Za Zhi 2011)
    772. [Genetic study of predisposition to community-acquired pneumonia]. (PubMed id 22312901)1 Moroz V.V....Rubanovich A.V. (Vestn. Akad. Med. Nauk SSSR 2011)
    773. Modulation of CYP1A1 activity by a Ginkgo biloba extract in the human intestinal Caco-2 cells. (PubMed id 21329749)1 Ribonnet L....Larondelle Y. (Toxicol. Lett. 2011)
    774. Polymorphisms of the CYP1A1, CYP2E1 and XRCC1 genes and cancer risk in a Southern Italian population: a case-control study. (PubMed id 21508386)1 Bianchino G....Sgambato A. (Anticancer Res. 2011)
    775. A large-scale candidate gene approach identifies SNPs in SOD2 and IL13 as predictive markers of response to preoperative chemoradiation in rectal cancer. (PubMed id 20644561)1 Ho-Pun-Cheung A....Lopez-Crapez E. (Pharmacogenomics J. 2011)
    776. Effect of CYP1A1 MSPI polymorphism on the relationship between TP53 mutation and CDKN2A hypermethylation in non-small cell lung cancer. (PubMed id 22154617)1 Tan C....Jin Y.T. (Arch. Med. Res. 2011)
    777. CYP1A1, GSTM1 and GSTT1 polymorphisms, tobacco and alcohol status and risk of head and neck squamous cell carcinoma. (PubMed id 21870186)1 LourenAso G.J....Lima C.S. (Tumour Biol. 2011)
    778. CYP1A1 gene polymorphisms: lack of association with breast cancer susceptibility in the southern region (Madurai) of India. (PubMed id 22292665)1 Kiruthiga P.V....Devi K.P. (Asian Pac. J. Cancer Prev. 2011)
    779. CYP1A2*1F and GSTM1 alleles are associated with susceptibility to porphyria cutanea tarda. (PubMed id 20957336)1 Wickliffe J.K....Anderson K.E. (Mol. Med. 2011)
    780. Importance of CYP1A1 polymorphism and its transcriptional regulation in ovarian and endometrial cancer. (PubMed id 22384629)1 Mrozikiewicz P.M....Drews K. (Ginekol. Pol. 2011)
    781. [Study of cytochrome P450 1A1 gene 3'-UTR 6235T-C polymorphism and susceptibility to breast cancer with Uighur medicine]. (PubMed id 21418988)1 Tuerxun M....Dolikun M. (Zhonghua Yi Xue Za Zhi 2011)
    782. Genetic variation in carcinogen metabolizing genes associated with oral cancer in pakistani population. (PubMed id 21545219)1 Masood N....Faryal R. (Asian Pac. J. Cancer Prev. 2011)
    783. Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. (PubMed id 21909115)1  ....Johnson T. (Nature 2011)
    784. Cytochrome P450 1A1 gene polymorphisms and endometrial cancer risk: a meta-analysis. (PubMed id 21270613)1 Sergentanis T.N....Vlahos N.F. (Int. J. Gynecol. Cancer 2011)
    785. Smoking, the xenobiotic pathway, and clubfoot. (PubMed id 21254355)1 Sommer A....Hecht J.T. (Birth Defects Res. Part A Clin. Mol. Teratol. 2011)
    786. A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease. (PubMed id 21378988)4 (Nat. Genet. 2011)
    787. CYP1A1 Ile462Val polymorphism and susceptibility to lung cancer: a meta-analysis based on 32 studies. (PubMed id 22025136)1 Wang J.J....Ma T.Y. (Eur. J. Cancer Prev. 2011)
    788. Relationship between CYP1A1 genetic polymorphisms and renal cancer in China. (PubMed id 22296350)1 Chen J....Jiang C.B. (Asian Pac. J. Cancer Prev. 2011)
    789. Is genetic polymorphism of ER-I+, CYP1A1, and CYP1B1 a risk factor for uterine leiomyoma? (PubMed id 20559649)1 El-Shennawy G.A....El Behery M.M. (Arch. Gynecol. Obstet. 2011)
    790. Associations of xenobiotic-metabolizing enzyme genotypes PON1Q192R, PON1L55M and CYP1A1*2A MspI with pathological symptoms of a rural population in south Greece. (PubMed id 21718208)1 Tsatsakis A.M....Koutis C. ( the fate of foreign compounds in biological systems 2011)
    791. The effect of CYP1A1 and GSTM1 gene polymorphisms in bladder cancer development in a Turkish population. (PubMed id 21709011)1 A9ztA1rk T....A^sbir T. (In Vivo 2011)
    792. A remark about CYP1A1 Thr461Asn genotype frequencies in a recent endometrial cancer case-control study. (PubMed id 21130723)1 Economopoulos K.P. and Sergentanis T.N. (Cancer Epidemiol 2011)
    793. Role of CYP1A1 (T6235C) polymorphism and cigarette smoking in the development of coronary heart disease in Tunisian population. (PubMed id 21869479)1 Achour A....Zemni R. (J. Genet. 2011)
    794. CYP1A1 Ile462Val polymorphism contributes to colorectal cancer risk: a meta-analysis. (PubMed id 21246002)1 Jin J.Q....Xia L.Y. (World J. Gastroenterol. 2011)
    795. Combined effects of serum trace metals and polymorphisms of CYP1A1 or GSTM1 on non-small cell lung cancer: a hospital based case-control study in China. (PubMed id 20638923)1 Jin Y....Xu Y. (Cancer Epidemiol 2011)
    796. CYP1A1, CYP2E1, and GSTM1 gene polymorphisms and susceptibility to colorectal and gastric cancer among Lebanese. (PubMed id 21385088)1 Darazy M....Abdel-Razzak Z. (Genet Test Mol Biomarkers 2011)
    797. Meta-analysis of cytochrome P4501A1 MspI gene polymorphism and childhood acute leukemia. (PubMed id 22365406)1 Zhang Y.D....Hu Q. (Biomed. Environ. Sci. 2011)
    798. Expression of xenobiotic metabolizing genes in head and neck cancer tissues. (PubMed id 21545198)1 Masood N....Kayani M.A. (Asian Pac. J. Cancer Prev. 2011)
    799. Soy isoflavones, CYP1A1, CYP1B1, and COMT polymorphisms, and breast cancer: a case-control study in southwestern China. (PubMed id 21438753)1 Wang Q....Huang Y. (DNA Cell Biol. 2011)
    800. CYP1A1, CYP3A5 and CYP3A7 polymorphisms and testicular cancer susceptibility. (PubMed id 20345875)1 Kristiansen W....Aschim E.L. (Int. J. Androl. 2011)
    801. CYP1A1 induction in the colon by serum: involvement of the PPARI+ pathway and evidence for a new specific human PPREI+ site. (PubMed id 21304969)1 Villard P.H....Seree E. (PLoS ONE 2011)
    802. The effect of CYP1A1 polymorphisms on the risk of lung cancer: a global meta-analysis based on 71 case-control studies. (PubMed id 21402622)1 Chen Z....Chen Z. (Mutagenesis 2011)
    803. Influence of genetic polymorphisms on frequency of micronucleated buccal epithelial cells in leukoplakia patients. (PubMed id 20850372)1 Mahimkar M.B....Patil T. (Oral Oncol. 2010)
    804. CYP2D6 mediates 4-hydroxylation of clonidine in vitro: implication for pregnancy-induced changes in clonidine clearance. (PubMed id 20570945)7 Claessens A.J....Hebert M.F. (Drug Metab. Dispos. 2010)
    805. CYP1A1, smoking and venous thromboembolism. (PubMed id 20664892)1 Zhu J....Wang C. (Thromb. Haemost. 2010)
    806. Evaluation of candidate genes for cholinesterase activity in farmworkers exposed to organophosphorus pesticides: association of single nucleotide polymorphisms in BCHE. (PubMed id 20529763)1 Howard T.D....Arcury T.A. (Environ. Health Perspect. 2010)
    807. [CYP1A1 polymorphisms, lack of glutathione S-transferase M1 (GSTM1), cooking oil fumes and lung cancer risk in non-smoking women]. (PubMed id 21211368)1 Zhu X.X....Gu Q.H. (Zhonghua Jie He He Hu Xi Za Zhi 2010)
    808. Methylation patterns of genes coding for drug-metabolizing enzymes in tamoxifen-resistant breast cancer tissues. (PubMed id 20628863)1 Kim S.J....Ro J. (J. Mol. Med. 2010)
    809. In utero tobacco exposure epigenetically modifies placental CYP1A1 expression. (PubMed id 20462615)1 Suter M....Aagaard-Tillery K. (Metab. Clin. Exp. 2010)
    810. Correlation of xenobiotic-metabolizing enzymes, oxidative stress and NFkappaB signaling with histological grade and menopausal status in patients with adenocarcinoma of the breast. (PubMed id 19995559)1 Vinothini G. and Nagini S. ( international journal of clinical chemistry 2010)
    811. Genetic polymorphisms in sex hormone metabolizing genes and drug response in women with epilepsy. (PubMed id 21121773)4 Grover S....Kukreti R. (Pharmacogenomics 2010)
    812. Single-nucleotide polymorphisms, acute rejection, and severity of tubulitis in kidney transplantation, accounting for center-to-center variation. (PubMed id 21085059)4 Israni A....Oetting W.S. (Transplantation 2010)
    813. Microarray-based detection of CYP1A1, CYP2C9, CYP2C19, CYP2D6, GSTT1, GSTM1, MTHFR, MTRR, NQO1, NAT2, HLA-DQA1, and AB0 allele frequencies in native Russians. (PubMed id 20373852)1 Gra O....Nasedkina T. (Genet Test Mol Biomarkers 2010)
    814. Errors and reproducibility of DNA array-based detection of allelic variants in ADME genes: PHARMAchip. (PubMed id 20136364)1 CuyA s E....de la Torre R. (Pharmacogenomics 2010)
    815. An association between BPDE-like DNA adduct levels and CYP1A1 and GSTM1 polymorphisma in pterygium. (PubMed id 20700368)1 Tung J.N....Cheng Y.W. (Mol. Vis. 2010)
    816. SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. (PubMed id 19934256)7 Preissner S....Preissner R. (Nucleic Acids Res. 2010)
    817. Early life environment, neurodevelopment and the interrelation with atopy. (PubMed id 20701904)1 Sunyer J....Torrent M. (Environ. Res. 2010)
    818. Toward personalized medicine in renal transplantation. (PubMed id 20970553)1 Lampreabe I....Olano-Martin E. (Transplant. Proc. 2010)
    819. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (Am. J. Hum. Genet. 2009)
    820. The effects of pyridoxine deficiency and supplementation on hematological profiles, lymphocyte function, and hepatic cytochrome P450 in B6C3F1 mice. (PubMed id 19637937)7 Tangjarukij C....Ruchirawat M. (J Immunotoxicol 2009)
    821. Utility of Nicotiana tabacum cell suspension cultures expressing human CYP1A1, CYP1A2 and CYP3A4 to study the oxidative metabolism of the herbicide 14C-fluometuron. (PubMed id 19356113)1 Breuer M.A....Schuphan I. (Drug Metab Lett 2009)
    822. Cytochrome P450 1A1, glutathione S-transferases M1 and T1 polymorphisms in Ovambos and Mongolians. (PubMed id 19264525)1 Fujihara J....Takeshita H. (Leg Med (Tokyo) 2009)
    823. Clinical pharmacokinetics of tyrosine kinase inhibitors. (PubMed id 19733976)7 van Erp N.P....Guchelaar H.J. (Cancer Treat. Rev. 2009)
    824. [Adverse birth outcomes of maternal smoking during pregnancy and genetic polymorphisms: exploiting gene-environment interaction]. (PubMed id 19797843)1 Sasaki S. and Kishi R. (Nihon Eiseigaku Zasshi 2009)
    825. High risk of 'de novo' acute myeloid leukaemia in individuals with cytochrome P450 A1 (CYP1A1) and NAD(P)H:quinone oxidoreductase 1 (NQO1) gene defects. (PubMed id 19456854)1 Yamaguti G.G....Lima C.S. (Eur. J. Haematol. 2009)
    826. Xenobiotic metabolizing gene variants, dietary heterocyclic amine intake, and risk of prostate cancer. (PubMed id 19223546)4 Koutros S....Cross A.J. (Cancer Res. 2009)
    827. Dissimilar in vitro and in vivo effects of ellagic acid and its microbiota-derived metabolites, urolithins, on the cytochrome P450 1A1. (PubMed id 19469472)7 GonzA!lez-SarrA-as A....EspA-n J.C. (J. Agric. Food Chem. 2009)
    828. Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. (PubMed id 19515014)7 Zhou S.F....Cai J.P. (Curr. Med. Chem. 2009)
    829. Identification of the human enzymes involved in the oxidative metabolism of dasatinib: an effective approach for determining metabolite formation kinetics. (PubMed id 18556438)7 Wang L....Zhang D. (Drug Metab. Dispos. 2008)
    830. Low organic solvent exposure and combined maternal-infant gene polymorphisms affect gestational age. (PubMed id 18070799)1 Qin X....Chen D. (Occup Environ Med 2008)
    831. Involvement of CREM in CYP1A1 induction through ligand-independent activation pathway of aryl hydrocarbon receptor in HepG2 cells. (PubMed id 18700132)1 Sasamori E....Kikuchi H. (Arch. Biochem. Biophys. 2008)
    832. Antipsychotic-induced tardive dyskinesia and polymorphic variations in COMT, DRD2, CYP1A2 and MnSOD genes: a meta-analysis of pharmacogenetic interactions. (PubMed id 18180754)1 Bakker P.R....van Os J. (Mol. Psychiatry 2008)
    833. Heat shock protein 90 inhibitors suppress aryl hydrocarbon receptor-mediated activation of CYP1A1 and CYP1B1 transcription and DNA adduct formation. (PubMed id 19138996)1 Hughes D....Dannenberg A.J. (Cancer Prev Res (Phila) 2008)
    834. Pharmacologic profiling of human and rat cytochrome P450 1A1 and 1A2 induction and competition. (PubMed id 18493746)1 Westerink W.M....Schoonen W.G. (Arch. Toxicol. 2008)
    835. A shuffled CYP1A library shows both structural integrity and functional diversity. (PubMed id 17823232)1 Johnston W.A....Gillam E.M. (Drug Metab. Dispos. 2007)
    836. Genotype frequencies of polymorphic GSTM1, GSTT1, and cytochrome P450 CYP1A1 in Mexicans. (PubMed id 18078203)1 Montero R....Camacho-Carranza R. (Hum. Biol. 2007)
    837. Using microarray analysis to evaluate genetic polymorphisms involved in the metabolism of environmental chemicals. (PubMed id 17642299)1 Ban S....Kishi R. (Fukuoka Igaku Zasshi 2007)
    838. Diversity of common alternative splicing variants of human cytochrome P450 1A1 and their association to carcinogenesis. (PubMed id 17549424)1 Bauer M....GrAobsch C. (Int. J. Oncol. 2007)
    839. Increased CYP1A1 expression in human exfoliated urothelial cells of cigarette smokers compared to non-smokers. (PubMed id 16947004)1 DAPrrenhaus A....Roos P.H. (Arch. Toxicol. 2007)
    840. CYP1A1 polymorphisms modify overall survival in acute myeloid leukemia patients. (PubMed id 17577786)1 Pelloso L.A....Chauffaille M.d.e. .L. (amp 2007)
    841. Urinary 1-hydroxypyrene level relative to vehicle exhaust exposure mediated by metabolic enzyme polymorphisms. (PubMed id 17429172)1 Chuang C.Y. and Chang C.C. (J Occup Health 2007)
    842. Differential metabolism of gefitinib and erlotinib by human cytochrome P450 enzymes. (PubMed id 17575239)7 Li J....Baker S.D. (Clin. Cancer Res. 2007)
    843. Recalling P446. P4501A1 (CYP1A1) opting for clinical application. (PubMed id 17786624)1 Hildebrandt A.G....Roots I. (Drug Metab. Rev. 2007)
    844. Differential effect of over-expressing UGT1A1 and CYP1A1 on xenobiotic assault in MCF-7 cells. (PubMed id 17981384)1 Leung H.Y....Leung L.K. (Toxicology 2007)
    845. Is the natural PCDD/PCDF mixture toxic for human placental JEG-3 cell line? The action of the toxicants on hormonal profile, CYP1A1 activity, DNA damage and cell apoptosis. (PubMed id 17623765)1 Augustowska K....Gregoraszczuk E.L. (amp 2007)
    846. Interactive effects between CYP1A1 genotypes and environmental polychlorinated dibenzo-p-dioxins and dibenzofurans exposures on liver function profile. (PubMed id 16407087)1 Chen H.L....Lee C.C. (J. Toxicol. Environ. Health Part A 2006)
    847. The absence of interaction between drug metabolizing enzyme genotypes and maternal lifestyle factors on glycophorin A somatic mutation frequency levels in newborns. (PubMed id 16424825)1 Nukui T....Romkes M. (Pharmacogenet. Genomics 2006)
    848. Effects of genetic polymorphisms CYP1A1, GSTM1, GSTT1 and GSTP1 on urinary 1-hydroxypyrene levels in sugarcane workers. (PubMed id 16914185)1 do Vale Bosso R.M....Conforti-Froes N.D. (Sci. Total Environ. 2006)
    849. Glutathione S-transferase polymorphisms associated with risk of breast cancer in southern Taiwan. (PubMed id 16713266)4 Chang T.W....Huang W. (Breast 2006)
    850. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (Science 2006)
    851. [Study on serum organochlorines pesticides (DDTs) level, CYP1A1 genetic polymorphism and risk of breast cancer: a case control study]. (PubMed id 16792888)1 Li J.Y....Tao P. (Zhonghua Liu Xing Bing Xue Za Zhi 2006)
    852. Xenobiotic-metabolizing genes and small-for-gestational-age births: interaction with maternal smoking. (PubMed id 16357593)1 Infante-Rivard C....Guiguet M. (Epidemiology 2006)
    853. Search for an association between the human CYP1A2 genotype and CYP1A2 metabolic phenotype. (PubMed id 16609368)1 Jiang Z....Nebert D.W. (Pharmacogenet. Genomics 2006)
    854. Japanese single nucleotide polymorphism database for 267 possible drug-related genes. (PubMed id 16367916)1 Iida A....Nakamura Y. (Cancer Sci. 2006)
    855. EPHX1 polymorphisms and the risk of lung cancer: a HuGE review. (PubMed id 16357600)1 Kiyohara C....Nakanishi Y. (Epidemiology 2006)
    856. Analysis of the DNA sequence and duplication history of human chromosome 15. (PubMed id 16572171)2 Zody M.C....Nusbaum C. (Nature 2006)
    857. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1 Olsen J.V....Mann M. (Cell 2006)
    858. Metabolism of 4-n-nonylphenol by non-modified and CYP1A1- and CYP1A2-transgenic cell cultures of tobacco. (PubMed id 16402549)1 Berger A....Schmidt B. (Z. Naturforsch., C, J. Biosci. 2005)
    859. Pharmacokinetics of 5-fluorouracil in rats with diabetes mellitus induced by streptozotocin. (PubMed id 15674819)7 Choi Y.H....Lee M.G. (amp 2005)
    860. Approval summary for erlotinib for treatment of patients with locally advanced or metastatic non-small cell lung cancer after failure of at least one prior chemotherapy regimen. (PubMed id 16166415)7 Johnson J.R....Pazdur R. (Clin. Cancer Res. 2005)
    861. Cytochrome P450 gene polymorphisms and risk of low birth weight. (PubMed id 15712341)1 Chen D....Wang L. (Genet. Epidemiol. 2005)
    862. Metabolism of melatonin by human cytochromes p450. (PubMed id 15616152)7 Ma X....Gonzalez F.J. (Drug Metab. Dispos. 2005)
    863. Human CYP1A1 variants lead to differential eicosapentaenoic acid metabolite patterns. (PubMed id 16153604)1 Schwarz D....Roots I. (Biochem. Biophys. Res. Commun. 2005)
    864. CYP1A1 is a major enzyme responsible for the metabolism of granisetron in human liver microsomes. (PubMed id 16248838)7 Nakamura H....Kitada M. (Curr. Drug Metab. 2005)
    865. CYP1A1 genetic polymorphisms in Ecuador, South America. (PubMed id 15920291)1 Paz-y-MiA+o C....Leone P.E. (Dis. Markers 2005)
    866. CYP2B6, CYP3A4, and CYP2C19 are responsible for the in vitro N-demethylation of meperidine in human liver microsomes. (PubMed id 15319333)1 RamA-rez J....Ratain M.J. (Drug Metab. Dispos. 2004)
    867. Phenacetin and chlorzoxazone biotransformation in aging male Fischer 344 rats. (PubMed id 15231049)7 Warrington J.S....von Moltke L.L. (J. Pharm. Pharmacol. 2004)
    868. Genetic polymorphisms of CYP1A1 in a Korean population. (PubMed id 15127181)1 Park D.W....Ryu D.Y. (Arch. Toxicol. 2004)
    869. [Gene polymorphism of xenobiotics in workers of petroleum and chemical industry]. (PubMed id 15152552)1 Makarova O.V....Viktorova T.V. (Med Tr Prom Ekol 2004)
    870. The human CYP1A1 gene is regulated in a developmental and tissue-specific fashion in transgenic mice. (PubMed id 15037607)1 Galijatovic A....Tukey R.H. (J. Biol. Chem. 2004)
    871. Quantitative contribution of CYP2D6 and CYP3A to oxycodone metabolism in human liver and intestinal microsomes. (PubMed id 15039299)1 Lalovic B....Shen D.D. (Drug Metab. Dispos. 2004)
    872. Analysis of CYP1A1 exon 7 polymorphisms by PCR-SSCP in a Brazilian population and description of two novel gene variations. (PubMed id 15013696)1 Amorim L.M....Pinto L.F. (Mutat. Res. 2004)
    873. Polymorphisms of cytochrome P450 1A1, glutathione S-transferases M1 and T1 in a Turkish population. (PubMed id 15177667)1 Ada A.O....Iscan M. (Toxicol. Lett. 2004)
    874. Identification of human cytochrome P(450)s that metabolise anti-parasitic drugs and predictions of in vivo drug hepatic clearance from in vitro data. (PubMed id 12920490)7 Li X.Q....Masimirembwa C.M. (Eur. J. Clin. Pharmacol. 2003)
    875. Association study of the vitamin D: 1alpha-hydroxylase (CYP1alpha) gene and type 2 diabetes mellitus in a Polish population. (PubMed id 12746631)1 Malecki M.T....Sieradzki J. (amp 2003)
    876. Genetic influence on cigarette-induced cardiovascular disease. (PubMed id 12704594)4 Wang X.L....Wang J. (Prog Cardiovasc Dis 2003)
    877. Metabolic pathways of dioxin by CYP1A1: species difference between rat and human CYP1A subfamily in the metabolism of dioxins. (PubMed id 12464257)1 Shinkyo R....Inouye K. (Arch. Biochem. Biophys. 2003)
    878. Agonist and chemopreventative ligands induce differential transcriptional cofactor recruitment by aryl hydrocarbon receptor. (PubMed id 14560034)1 Hestermann E.V. and Brown M. (Mol. Cell. Biol. 2003)
    879. Cytochrome p450 and glutathione transferase expression in human breast cancer. (PubMed id 12738724)1 El-Rayes B.F....Philip P.A. (Clin. Cancer Res. 2003)
    880. Effect of genotype on steady-state CYP1A1 gene expression in human peripheral lymphocytes. (PubMed id 12527337)1 Garte S....Taioli E. (Biochem. Pharmacol. 2003)
    881. Cooking methods, metabolic polymorphisms and colorectal cancer. (PubMed id 11917213)4 Pisani P. and Mitton N. (Eur. J. Cancer Prev. 2002)
    882. Genetic susceptibility--molecular epidemiology of head and neck cancer. (PubMed id 11981277)4 Sturgis E.M. and Wei Q. (Curr Opin Oncol 2002)
    883. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    884. High frequency of CYP1A1*2C allele in Brazilian populations. (PubMed id 12030651)1 Gaspar P.A....Weimer T.A. (Hum. Biol. 2002)
    885. Oxidation of the flavonoids galangin and kaempferide by human liver microsomes and CYP1A1, CYP1A2, and CYP2C9. (PubMed id 11792676)1 Otake Y. and Walle T. (Drug Metab. Dispos. 2002)
    886. [The distributive features of three kinds of metabolic genes polymorphisms in population of Han nationality in south area of China]. (PubMed id 12170467)1 Shen J....Xu X. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2002)
    887. Low-penetrance genes and their involvement in colorectal cancer susceptibility. (PubMed id 12433710)4 de Jong M.M....Kleibeuker J.H. (amp 2002)
    888. Genetic polymorphisms and lung cancer susceptibility: a review. (PubMed id 12234692)4 Kiyohara C....Hopkin J.M. (Lung Cancer 2002)
    889. Metabolizing enzyme localization and activities in the first trimester human placenta: the effect of maternal and gestational age, smoking and alcohol consumption. (PubMed id 12351530)1 Collier A.C....Keelan J.A. (Hum. Reprod. 2002)
    890. Metabolism of tamoxifen by recombinant human cytochrome P450 enzymes: formation of the 4-hydroxy, 4'-hydroxy and N-desmethyl metabolites and isomerization of trans-4-hydroxytamoxifen. (PubMed id 12124303)7 Crewe H.K....Gillam E.M. (Drug Metab. Dispos. 2002)
    891. Aromatic DNA adduct levels in coke oven workers: correlation with polymorphisms in genes GSTP1, GSTM1, GSTT1 and CYP1A1. (PubMed id 12034316)1 Teixeira J.P....Rueff J. (Mutat. Res. 2002)
    892. Genetic polymorphisms of glutathione S-transferases M1 and T1 associated with susceptibility to aflatoxin-related hepatocarcinogenesis among chronic hepatitis B carriers: a nested case-control study in Taiwan. (PubMed id 11470760)1 Sun C.A....Santella R.M. (Carcinogenesis 2001)
    893. Childhood acute lymphoblastic leukemia: genetic determinants of susceptibility and disease outcome. (PubMed id 12041882)4 Krajinovic M....Sinnett D. (Rev Environ Health 2001)
    894. Modulation of DNA and protein adducts in smokers by genetic polymorphisms in GSTM1,GSTT1, NAT1 and NAT2. (PubMed id 11470992)1 Godschalk R.W....Van Schooten F.J. (Pharmacogenetics 2001)
    895. CYP1A2 is expressed along with CYP1A1 in the human lung. (PubMed id 11485833)1 Wei C....Iba M.M. (Cancer Lett. 2001)
    896. Ethnic differences in distributions of GSTM1 and GSTT1 homozygous &quot;null&quot; genotypes in India. (PubMed id 11459424)1 Roy B....Sil S.K. (Hum. Biol. 2001)
    897. Biological monitoring the exposure to polycyclic aromatic hydrocarbons of coke oven workers in relation to smoking and genetic polymorphisms for GSTM1 and GSTT1. (PubMed id 11418090)1 van Delft J.H....Hopmans P.M. (Ann Occup Hyg 2001)
    898. Gene-environment interactions in pancreatic cancer. (PubMed id 12120227)4 Malats N. (Pancreatology 2001)
    899. The m2 and m4 polymorphisms in CYP1A1 by NcoI digest-revision of detection method. (PubMed id 10612842)1 Israeli D....Friedman E. (Hum. Mutat. 2000)
    900. Inhibition of human cytochrome P450 enzymes by 1,4-dihydropyridine calcium antagonists: prediction of in vivo drug-drug interactions. (PubMed id 10805063)7 Katoh M....Yokoi T. (Eur. J. Clin. Pharmacol. 2000)
    901. Cytochrome P4501A1 polymorphisms in South American Indians. (PubMed id 11236859)1 Kvitko K....Hutz M.H. (Hum. Biol. 2000)
    902. Identification of human cytochrome P450s involved in the formation of all-trans-retinoic acid principal metabolites. (PubMed id 11093772)7 Marill J....Chabot G.G. (Mol. Pharmacol. 2000)
    903. CYP1A1. (PubMed id 10493257)1 Kawajiri K. (IARC Sci. Publ. 1999)
    904. Polyspecific organic anion transporting polypeptides mediate hepatic uptake of amphipathic type II organic cations. (PubMed id 10490898)7 van Montfoort J.E....Meier P.J. (J. Pharmacol. Exp. Ther. 1999)
    905. Inhibition of rat lung mixed-function oxidase activity following repeated low-level toluene inhalation: possible role of toluene metabolites. (PubMed id 9726784)7 Furman G.M....Schatz R.A. (J. Toxicol. Environ. Health Part A 1998)
    906. Molecular genetics of the human cytochrome P450 monooxygenase superfamily. (PubMed id 9890157)1 Smith G....Wolf C.R. ( the fate of foreign compounds in biological systems 1998)
    907. In vitro kinetics of two human CYP1A1 variant enzymes suggested to be associated with interindividual differences in cancer susceptibility. (PubMed id 9070254)4 Persson I....Ingelman-Sundberg M. (Biochem. Biophys. Res. Commun. 1997)
    908. Pharmacokinetic-pharmacodynamic relationship of the selective serotonin reuptake inhibitors. (PubMed id 8968657)7 Baumann P. (Clin Pharmacokinet 1996)
    909. Human cytochrome P450 mono-oxygenase system is suppressed by propofol. (PubMed id 7772432)7 Chen T.L....Liu C.C. (Br J Anaesth 1995)
    910. A specific African-American CYP1A1 polymorphism is associated with adenocarcinoma of the lung. (PubMed id 7834609)4 Taioli E....Garte S.J. (Cancer Res. 1995)
    911. Picrotoxin is a CYP1A1 inducer in rainbow trout hepatocytes. (PubMed id 7575510)7 Sadar M.D....Andersson T.B. (Biochem. Biophys. Res. Commun. 1995)
    912. A race-specific genetic polymorphism in the CYP1A1 gene is not associated with lung cancer in African Americans. (PubMed id 8020143)4 Kelsey K.T....Spitz M.R. (Carcinogenesis 1994)
    913. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)1 Maruyama K. and Sugano S. (Gene 1994)
    914. Caffeine, estradiol, and progesterone interact with human CYP1A1 and CYP1A2. Evidence from cDNA-directed expression in Saccharomyces cerevisiae. (PubMed id 8095225)1 Eugster H.P....Sengstag C. (Drug Metab. Dispos. 1993)
    915. CYP1A1: friend or foe? (PubMed id 8313840)1 Beresford A.P. (Drug Metab. Rev. 1993)
    916. Subcellular localization of cytochrome P450, and activities of several enzymes responsible for drug metabolism in the human brain. (PubMed id 8442765)1 Ghersi-Egea J.F....Minn A. (Biochem. Pharmacol. 1993)
    917. Xenobiotic responsive element in the 5'-upstream region of the human P-450c gene. (PubMed id 1761516)1 Kubota M....Fujii-Kuriyama Y. (J. Biochem. 1991)
    918. Identification of genetically high risk individuals to lung cancer by DNA polymorphisms of the cytochrome P450IA1 gene. (PubMed id 1691986)1 Kawajiri K....Watanabe J. (FEBS Lett. 1990)
    919. Two RFLPs associated with the human P1450 gene linked to the MPI locus on chromosome 15 [HGM8 D15S8]. (PubMed id 3714481)1 Jaiswal A.K. and Nebert D.W. (Nucleic Acids Res. 1986)
    920. Assignment of the human 2,3,7,8-tetrachlorodibenzo-p-dioxin-inducible cytochrome P1-450 gene to chromosome 15. (PubMed id 4000952)1 Hildebrand C.E....Nebert D.W. (Nucleic Acids Res. 1985)
    921. Characterization of the interaction of amphipathic cytochrome b5 with stearyl coenzyme A desaturase and NADPH:cytochrome P-450 reductase. (PubMed id 6102994)1 Dailey H.A. and Strittmatter P. (J. Biol. Chem. 1980)
    922. Environmental factors and aryl hydrocarbon hydroxylase activity (CYP1A1 phenotype) in human lymphocytes. (PubMed id 9465551)9 Kiyohara C. and Hirohata T. (J Epidemiol 1997)
    923. Detection of CYP1A1 protein in human liver and induction by TCDD in precision-cut liver slices incubated in dynamic organ culture. (PubMed id 9744530)9 Drahushuk A.T....Olson J.R. (Carcinogenesis 1998)
    924. Monocyte aryl hydrocarbon hydroxylase (AHH) activity mimics Kupffer cell and hepatocyte AHH activity in an animal model of liver disease. (PubMed id 1802352)9 Peterson T.C....Malatjalian D.A. (Can. J. Physiol. Pharmacol. 1991)
    925. An autoregulatory loop controlling CYP1A1 gene expression: role of H(2)O(2) and NFI. (PubMed id 10490621)9 Morel Y....Barouki R. (Mol. Cell. Biol. 1999)
    926. Expression of human cytochrome P450 1A1 in DNA repair deficient and proficient human fibroblasts stably transformed with an inducible expression vector. (PubMed id 8353849)9 States J.C....Runge-Morris M. (Carcinogenesis 1993)
    927. The role of redox-sensitive transcription factors NF-kappaB and AP-1 in the modulation of the Cyp1a1 gene by mercury, lead, and copper. (PubMed id 18078826)9 Korashy H.M. and El-Kadi A.O. (amp 2008)
    928. Requirement of aryl hydrocarbon receptor overexpression for CYP1B1 up-regulation and cell growth in human lung adenocarcinomas. (PubMed id 17200336)9 Chang J.T....Lin P. (Clin. Cancer Res. 2007)
    929. Systemic effects of arctic pollutants in beluga whales indicated by CYP1A1 expression. (PubMed id 16263517)9 Wilson J.Y....Stegeman J.J. (Environ. Health Perspect. 2005)
    930. tert-Butylhydroquinone is a novel aryl hydrocarbon receptor ligand. (PubMed id 15608132)9 Gharavi N. and El-Kadi A.O. (Drug Metab. Dispos. 2005)
    931. Arsenite inhibition of CYP1A1 induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin is independent of cell cycle arrest. (PubMed id 15630080)9 Bonzo J.A....Tukey R.H. (Mol. Pharmacol. 2005)
    932. Mechanisms of arsenite-mediated decreases in benzo[k]fluoranthene-induced human cytochrome P4501A1 levels in HepG2 cells. (PubMed id 15576448)9 Bessette E.E....Kaminsky L.S. (Drug Metab. Dispos. 2005)
    933. Regulation of NAD(P)H:quinone oxidoreductase 1 gene expression by CYP1A1 activity. (PubMed id 15044633)9 Marchand A....Garlatti M. (Mol. Pharmacol. 2004)
    934. Novel functional association of serine palmitoyltransferase subunit 1-A peptide in sphingolipid metabolism with cytochrome P4501A1 transactivation and proliferative capacity of the human Glioma LN18 brain tumor cell line. (PubMed id 16968971)9 Yerokun T. and Stewart J. (Int J Environ Res Public Health 2006)
    935. Suppressive effect of 1-nitropyrene on benzo[a]pyrene-induced CYP1A1 protein expression in HepG2 cells. (PubMed id 16280210)9 Cherng S.H....Lee H. (Toxicol. Lett. 2006)
    936. Expression of aryl hydrocarbon receptor repressor in normal human tissues and inducibility by polycyclic aromatic hydrocarbons in human tumor-derived cell lines. (PubMed id 12655030)9 Tsuchiya Y....Yokoi T. (Toxicol. Sci. 2003)
    937. Regulatory interactions among three members of the vertebrate aryl hydrocarbon receptor family: AHR repressor, AHR1, and AHR2. (PubMed id 11742002)9 Karchner S.I....Hahn M.E. (J. Biol. Chem. 2002)
    938. Detailed characterization of experimentally derived human hepatic CYP1A1 activity and expression using differential inhibition of ethoxyresorufin O-deethylation by fluvoxamine. (PubMed id 11599655)9 Sy S.K....Kalow W. (Eur. J. Clin. Pharmacol. 2001)
    939. Dietary flavonols quercetin and kaempferol are ligands of the aryl hydrocarbon receptor that affect CYP1A1 transcription differentially. (PubMed id 10359656)9 Ciolino H.P....Yeh G.C. (Biochem. J. 1999)
    940. The relationship between CYP1A1 aryl hydrocarbon hydroxylase activity and lung cancer in a Japanese population. (PubMed id 9731718)9 Kiyohara C....Hirohata T. (Pharmacogenetics 1998)
    941. Cytochrome P450 1A1 induction in rat lymphoid tissues following in vivo and in vitro exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin requires protein kinase C. (PubMed id 9392454)9 Stephen F.D....Olson J.R. (Toxicology 1997)
    942. The relationship between aryl hydrocarbon hydroxylase and polymorphisms of the CYP1A1 gene. (PubMed id 8609043)9 Kiyohara C....Inutsuka S. (Jpn. J. Cancer Res. 1996)
    943. Cytochrome P4501A1 mediates the metabolism of 2,3,7,8-tetrachlorodibenzofuran in the rat and human. (PubMed id 8236259)9 Tai H.L....Olson J.R. (Toxicol. Appl. Pharmacol. 1993)
    944. Construction of a system that simultaneously evaluates CYP1A1 and CYP1A2 induction in a stable human-derived cell line using a dual reporter plasmid. (PubMed id 20460824)9 Sato W....Nagata K. (Drug Metab. Pharmacokinet. 2010)
    945. Differential protection by human glutathione S-transferase P1 against cytotoxicity of benzo[a]pyrene, dibenzo[a,l]pyrene, or their dihydrodiol metabolites, in bi-transgenic cell lines that co-express rat versus human cytochrome P4501A1. (PubMed id 19330882)9 Kabler S.L....Townsend A.J. (Chem. Biol. Interact. 2009)
    946. 1-Nitropyrene stabilizes the mRNA of cytochrome P450 1a1, a carcinogen-metabolizing enzyme, via the Akt pathway. (PubMed id 19961161)9 Chu W.C....Su J.G. (Chem. Res. Toxicol. 2009)
    947. Transcriptional activation and posttranscriptional modification of Cyp1a1 by arsenite, cadmium, and chromium. (PubMed id 17606337)9 Elbekai R.H. and El-Kadi A.O. (Toxicol. Lett. 2007)
    948. Induction of CYP1A1 in tumor cells by the antitumor agent 2-[4-amino-3-methylphenyl]-5-fluoro-benzothiazole: a potential surrogate marker for patient sensitivity. (PubMed id 14707267)9 Hose C.D....Monks A. (Mol. Cancer Ther. 2003)
    949. Oltipraz inhibits 3-methylcholanthrene induction of CYP1A1 by CCAAT/enhancer-binding protein activation. (PubMed id 12941938)9 Cho I.J. and Kim S.G. (J. Biol. Chem. 2003)
    950. Correlation between gene expression of aryl hydrocarbon receptor (AhR), hydrocarbon receptor nuclear translocator (Arnt), cytochromes P4501A1 (CYP1A1) and 1B1 (CYP1B1), and inducibility of CYP1A1 and CYP1B1 in human lymphocytes. (PubMed id 12520072)9 Lin P....Chang T.H. (Toxicol. Sci. 2003)
    951. Human lung microsomal cytochrome P4501A1 (CYP1A1) activities: impact of smoking status and CYP1A1, aryl hydrocarbon receptor, and glutathione S-transferase M1 genetic polymorphisms. (PubMed id 11489750)9 Smith G.B....Massey T.E. (amp 2001)
    952. Suppression of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-mediated CYP1A1 and CYP1B1 induction by 12-O-tetradecanoylphorbol-13-acetate: role of transforming growth factor beta and mitogen-activated protein kinases. (PubMed id 11728381)9 Guo M....Reiners J.J. (Biochem. Pharmacol. 2001)
    953. An uncommon phenotype of poor inducibility of CYP1A1 in human lung is not ascribable to polymorphisms in the AHR, ARNT, or CYP1A1 genes. (PubMed id 11186136)9 Anttila S....Hankinson O. (Pharmacogenetics 2000)
    954. Characterization of the dose-response of CYP1B1, CYP1A1, and CYP1A2 in the liver of female Sprague-Dawley rats following chronic exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin. (PubMed id 9931287)9 Walker N.J....Sutter T.R. (Toxicol. Appl. Pharmacol. 1999)
    955. Characterization of the rabbit CYP1A1 and CYP1A2 genes: developmental and dioxin-inducible expression of rabbit liver P4501A1 and P4501A2. (PubMed id 1567227)9 Strom D.K....Tukey R.H. (Arch. Biochem. Biophys. 1992)
    956. Characterization of major phytocannabinoids, cannabidiol and cannabinol, as isoform-selective and potent inhibitors of human CYP1 enzymes. (PubMed id 20117100)9 Yamaori S....Watanabe K. (Biochem. Pharmacol. 2010)
    957. Involvement of oxidative stress and activation of aryl hydrocarbon receptor in elevation of CYP1A1 expression and activity in lung cells and tissues by arsenic: an in vitro and in vivo study. (PubMed id 19033395)9 Wu J.P....Lin P. (Toxicol. Sci. 2009)
    958. Conserved genomic structure of the Cyp1a1 and Cyp1a2 loci and their dioxin responsive elements cluster. (PubMed id 19026991)9 Nukaya M. and Bradfield C.A. (Biochem. Pharmacol. 2009)
    959. Omeprazole transactivates human CYP1A1 and CYP1A2 expression through the common regulatory region containing multiple xenobiotic-responsive elements. (PubMed id 18502397)9 Yoshinari K....Yamazoe Y. (Biochem. Pharmacol. 2008)
    960. Interindividual variation in CYP1A1 expression in breast tissue and the role of genetic polymorphism. (PubMed id 11062177)9 Goth-Goldstein R....Russell M. (Carcinogenesis 2000)
    961. Characterization of CYP1B1 and CYP1A1 expression in human mammary epithelial cells: role of the aryl hydrocarbon receptor in polycyclic aromatic hydrocarbon metabolism. (PubMed id 9622076)9 Larsen M.C....Jefcoate C.R. (Cancer Res. 1998)
    962. Differential expression of CYP1A1 and CYP1B1 in human breast epithelial cells and breast tumor cells. (PubMed id 9498279)9 Spink D.C....Sutter T.R. (Carcinogenesis 1998)
    963. Cell-specific regulation of human CYP1A1 and CYP1B1 genes. (PubMed id 9102211)9 Kress S. and Greenlee W.F. (Cancer Res. 1997)
    964. Genetic polymorphism of cytochromes P450 1A1, 2D6 and 2E1: regulation and toxicological significance. (PubMed id 7620940)9 Rannug A....Ingelman-Sundberg M. (J. Occup. Environ. Med. 1995)
    965. [A role of aryl hydrocarbon hydroxylase inducibility in susceptibility to lung carcinogenesis]. (PubMed id 8126925)9 Kiyohara C. and Hirohata T. (Nihon Eiseigaku Zasshi 1994)
    966. Cytotoxicity and genotoxicity of (+/-)-benzo[a]pyrene-trans-7,8-dihydrodiol in CYP1A1-expressing human fibroblasts quantitatively correlate with CYP1A1 expression level. (PubMed id 7923575)9 Quan T....States J.C. (Carcinogenesis 1994)
    967. CYP1A1 specificity of Verlukast epoxidation in mice, rats, rhesus monkeys, and humans. (PubMed id 7905381)9 Grossman S.J....Yergey J.A. (Drug Metab. Dispos. 1993)
    968. Racial differences in restriction fragment length polymorphisms and messenger RNA inducibility of the human CYP1A1 gene. (PubMed id 8093594)9 Cosma G....Garte S.J. (amp 1993)
    969. Potentiation of CYP1A1 gene expression in MCF-7 human breast cancer cells cotreated with 2,3,7,8-tetrachlorodibenzo-p-dioxin and 12-O-tetradecanoylphorbol-13-acetate. (PubMed id 8396892)9 Moore M....Safe S. (Arch. Biochem. Biophys. 1993)
    970. Is aryl hydrocarbon hydroxylase activity a new prognostic indicator for breast cancer? (PubMed id 2021546)9 PyykkAP K....PerkiAP T. (Br. J. Cancer 1991)
    971. Persistent induction of cytochrome P4501A1 in human hepatoma cells by 3-methylcholanthrene: evidence for sustained transcriptional activation of the CYP1A1 promoter. (PubMed id 20051482)9 Fazili I.S....Moorthy B. (J. Pharmacol. Exp. Ther. 2010)
    972. CYP1A1 and CYP1B1 gene expression and DNA adduct formation in normal human mammary epithelial cells exposed to benzo[a]pyrene in the absence or presence of chlorophyllin. (PubMed id 20163913)9 John K....Weston A. (Cancer Lett. 2010)
    973. Roles of coactivator proteins in dioxin induction of CYP1A1 and CYP1B1 in human breast cancer cells. (PubMed id 18842620)9 Taylor R.T....Hankinson O. (Toxicol. Sci. 2009)
    974. Constitutive regulation of CYP1B1 by the aryl hydrocarbon receptor (AhR) in pre-malignant and malignant mammary tissue. (PubMed id 18059014)9 Yang X....Sherr D.H. (J. Cell. Biochem. 2008)
    975. HDAC1 bound to the Cyp1a1 promoter blocks histone acetylation associated with Ah receptor-mediated trans-activation. (PubMed id 17707923)9 Schnekenburger M....Puga A. (Biochim. Biophys. Acta 2007)
    976. Expression of cytochrome P450 1A1 and its contribution to oxidation of a potential human carcinogen 1-phenylazo-2-naphthol (Sudan I) in human livers. (PubMed id 15766589)9 StiborovA! M....Hodek P. (Cancer Lett. 2005)
    977. PPARalpha activation potentiates AhR-induced CYP1A1 expression. (PubMed id 16137816)9 Fallone F....Lacarelle B. (Toxicology 2005)
    978. Regulatory mechanisms modulating the expression of cytochrome P450 1A1 gene by heavy metals. (PubMed id 16093525)9 Korashy H.M. and El-Kadi A.O. (Toxicol. Sci. 2005)
    979. CYP1A1 and CYP1B1 expressions in medulloblastoma cells are AhR-independent and have no direct link with resveratrol-induced differentiation and apoptosis. (PubMed id 15893423)9 Wu M.L....Liu J. (Neurosci. Lett. 2005)
    980. Induction of CYP1A1 and CYP1B1 and formation of carcinogen-DNA adducts in normal human mammary epithelial cells treated with benzo[a]pyrene. (PubMed id 15808407)9 Keshava C....Weston A. (Cancer Lett. 2005)
    981. CCAAT/enhancer binding protein activation by PD98059 contributes to the inhibition of AhR-mediated 3-methylcholanthrene induction of CYP1A1. (PubMed id 16393856)9 Shin S.M....Kim S.G. ( the fate of foreign compounds in biological systems 2005)
    982. Constitutive and inducible expression of cytochromes P4501A (CYP1A1 and CYP1A2) in normal prostate and prostate cancer cells. (PubMed id 14743400)9 Sterling K.M. and Cutroneo K.R. (J. Cell. Biochem. 2004)
    983. Comparison of gene expression patterns between 2,3,7,8-tetrachlorodibenzo-p-dioxin and a natural arylhydrocarbon receptor ligand, indirubin. (PubMed id 15056799)9 Adachi J....Matsuda T. (Toxicol. Sci. 2004)
    984. Functional evaluation of novel single nucleotide polymorphisms and haplotypes in the promoter regions of CYP1B1 and CYP1A1 genes. (PubMed id 12884367)9 Han W....Spivack S.D. (Mol. Carcinog. 2003)
    985. Benzo[g,h,i]perylene synergistically transactivates benzo[a]pyrene-induced CYP1A1 gene expression by aryl hydrocarbon receptor pathway. (PubMed id 11141357)9 Cherng S.H....Lee H. (Toxicol. Appl. Pharmacol. 2001)
    986. Suppression of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-mediated aryl hydrocarbon receptor transformation and CYP1A1 induction by the phosphatidylinositol 3-kinase inhibitor 2-(4-morpholinyl)-8-phenyl-4H-1- benzopyran-4-one (LY294002). (PubMed id 10927021)9 Guo M....Reiners J.J. (Biochem. Pharmacol. 2000)
    987. Induction of cytochrome P450 1A1 in human hepatoma HepG2 cells by 6-nitrochrysene. (PubMed id 11033235)9 Chen R.M....Ueng T.H. (Toxicol. Lett. 2000)
    988. Expression of CYP1A1 and CYP1B1 depends on cell-specific factors in human breast cancer cell lines: role of estrogen receptor status. (PubMed id 10357772)9 Angus W.G....Jefcoate C.R. (Carcinogenesis 1999)
    989. The steroid hormone dehydroepiandrosterone inhibits CYP1A1 expression in vitro by a post-transcriptional mechanism. (PubMed id 10575002)9 Ciolino H.P. and Yeh G.C. (J. Biol. Chem. 1999)
    990. The flavonoid galangin is an inhibitor of CYP1A1 activity and an agonist/antagonist of the aryl hydrocarbon receptor. (PubMed id 10188874)9 Ciolino H.P. and Yeh G.C. (Br. J. Cancer 1999)
    991. Induction and localization of cytochrome P450 1B1 (CYP1B1) protein in the livers of TCDD-treated rats: detection using polyclonal antibodies raised to histidine-tagged fusion proteins produced and purified from bacteria. (PubMed id 9525272)9 Walker N.J....Sutter T.R. (Carcinogenesis 1998)
    992. Localization of CYP1A1 mRNA in human lung by in situ hybridization: comparison with immunohistochemical findings. (PubMed id 9639391)9 Saarikoski S.T....Anttila S. (Int. J. Cancer 1998)
    993. Diosmin and diosmetin are agonists of the aryl hydrocarbon receptor that differentially affect cytochrome P450 1A1 activity. (PubMed id 9661887)9 Ciolino H.P....Yeh G.C. (Cancer Res. 1998)
    994. Cytochrome P4501A1 and glutathione S-transferase M1 genotypes as risk factors for prostate cancer in Japan. (PubMed id 9861231)9 Murata M....Yatani R. (Jpn. J. Clin. Oncol. 1998)
    995. Resveratrol inhibits transcription of CYP1A1 in vitro by preventing activation of the aryl hydrocarbon receptor. (PubMed id 9865727)9 Ciolino H.P....Yeh G.C. (Cancer Res. 1998)
    996. Truncal tumor site is associated with high risk of multiple basal cell carcinoma and is influenced by glutathione S-transferase, GSTT1, and cytochrome P450, CYP1A1 genotypes, and their interaction. (PubMed id 9077484)9 Lear J.T....Fryer A.A. (J. Invest. Dermatol. 1997)
    997. Genotyping of the CYP1A1 and GSTM1 genes in esophageal carcinoma patients with special reference to smoking. (PubMed id 9307183)9 Nimura Y....Iida F. (Cancer 1997)
    998. Effects of polychlorinated dibenzo-p-dioxin and dibenzofuran congeners in human lymphoblastoid cells on aryl hydrocarbon hydroxylase activity. (PubMed id 8528652)9 Kiyohara C....Masuda Y. (Chemosphere 1995)
    999. Detection of CYP1A1 gene polymorphism using designed RFLP and distributions of CYP1A1 genotypes in Japanese. (PubMed id 7591186)9 Oyama T....Yasumoto K. (Int Arch Occup Environ Health 1995)
    1000. Combined effect of CYP1A1 inducibility and GSTM1 polymorphism on histological type of lung cancer. (PubMed id 8020145)9 Anttila S....Vainio H. (Carcinogenesis 1994)
    1001. Enzyme induction of the early chick embryo by airborne particulate extracts. (PubMed id 8481108)9 Matsumoto H. (Arch. Toxicol. 1993)
    1002. Interleukin-1 beta suppresses the induction of P4501A1 and P4501A2 mRNAs in isolated hepatocytes. (PubMed id 1569064)9 Barker C.W....Pasco D.S. (J. Biol. Chem. 1992)
    1003. Stable expression of mouse Cyp1a1 and human CYP1A2 cDNAs transfected into mouse hepatoma cells lacking detectable P450 enzyme activity. (PubMed id 2206399)9 Puga A....Nebert D.W. (DNA Cell Biol. 1990)
    1004. 1,10-phenanthroline stabilizes mRNA of the carcinogen-metabolizing enzyme, cytochrome P450 1a1. (PubMed id 19896525)9 Chou M.T....Su J.G. (Toxicol. Lett. 2010)
    1005. Importance of CYP1A1 and CYP1B1 in bioactivation of benzo[a]pyrene in human lung cell lines. (PubMed id 19879933)9 Uppstad H....Mollerup S. (Toxicol. Lett. 2010)
    1006. Omeprazole alleviates benzo[a]pyrene cytotoxicity by inhibition of CYP1A1 activity in human and mouse hepatoma cells. (PubMed id 18793272)9 Shiizaki K....Yagi T. (amp 2008)
    1007. Mouse lung CYP1A1 catalyzes the metabolic activation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). (PubMed id 17052995)9 Ma X....Gonzalez F.J. (Carcinogenesis 2007)
    1008. Regulation of CYP1A1 gene expression by the antioxidant tert-butylhydroquinone. (PubMed id 16581943)9 Schreiber T.D....MA1nzel P.A. (Drug Metab. Dispos. 2006)
    1009. Cytochrome P450 1A1 and 1B1 in human blood lymphocytes are not suitable as biomarkers of exposure to dioxin-like compounds: polymorphisms and interindividual variation in expression and inducibility. (PubMed id 15659568)9 van Duursen M.B....van den Berg M. (Toxicol. Sci. 2005)
    1010. The role of protein kinase C in regulation of TCDD-mediated CYP1A1 gene expression. (PubMed id 15947024)9 Machemer D.E. and Tukey R.H. (Toxicol. Sci. 2005)
    1011. Arachidonic and eicosapentaenoic acid metabolism by human CYP1A1: highly stereoselective formation of 17(R),18(S)-epoxyeicosatetraenoic acid. (PubMed id 15041462)9 Schwarz D....Roots I. (Biochem. Pharmacol. 2004)
    1012. Induction of CYP1A1 and CYP1B1 in T-47D human breast cancer cells by benzo[a]pyrene is diminished by arsenite. (PubMed id 11854143)9 Spink D.C....Kaminsky L.S. (Drug Metab. Dispos. 2002)
    1013. CYP1A1 induction by pyridine and its metabolites in HepG2 cells. (PubMed id 12147272)9 Iba M.M....Fung J. (Arch. Biochem. Biophys. 2002)
    1014. Sudan I is a potential carcinogen for humans: evidence for its metabolic activation and detoxication by human recombinant cytochrome P450 1A1 and liver microsomes. (PubMed id 12384524)9 StiborovA! M....Frei E. (Cancer Res. 2002)
    1015. A high-throughput cell-based reporter gene system for measurement of CYP1A1 induction. (PubMed id 12628305)9 Cui X....Cheng K.C. (J Pharmacol Toxicol Methods 2002)
    1016. Induction of CYP1A by benzo[k]fluoranthene in human hepatocytes: CYP1A1 or CYP1A2? (PubMed id 11370663)9 Liu N....Kaminsky L.S. (Arch. Biochem. Biophys. 2001)
    1017. Differential metabolism of benzo[a]pyrene and benzo[a]pyrene-7,8-dihydrodiol by human CYP1A1 variants. (PubMed id 11238186)9 Schwarz D....Roots I. (Carcinogenesis 2001)
    1018. Failure of Ah receptor to mediate induction of cytochromes P450 in the CYP1 family in the human hepatoma line SK-Hep-1. (PubMed id 11147830)9 Roberts E.A....Yang S. (Arch. Biochem. Biophys. 2000)
    1019. Estrogen receptor reduces CYP1A1 induction in cultured human endometrial cells. (PubMed id 9920887)9 Ricci M.S....Toscano W.A. (J. Biol. Chem. 1999)
    1020. Prognostic significance of germ line polymorphisms of the CYP1A1 and glutathione S-transferase genes in patients with non-small cell lung cancer. (PubMed id 8706015)9 Goto I....Kawajiri K. (Cancer Res. 1996)
    1021. Interferon-mediated changes in the expression of CYP1A1 in human B lymphoblastoid (AHH-1 TK +/-) cells. (PubMed id 8834482)9 Delaporte E....Renton K.W. (Can. J. Physiol. Pharmacol. 1995)
    1022. Characterization of hamster CYP1A1 gene: inducible expression and negative regulation. (PubMed id 7883754)9 Sagami I....Watanabe M. (J. Biochem. 1994)
    1023. 1462V mutation in the human CYP1A1 gene: lack of correlation with either the Msp I 1.9 kb (M2) allele or CYP1A1 inducibility in a three-generation family of east Mediterranean descent. (PubMed id 7516235)9 Wedlund P.J....Nebert D.W. (Pharmacogenetics 1994)
    1024. CYP1A1 mRNA levels as a human exposure biomarker: use of quantitative polymerase chain reaction to measure CYP1A1 expression in human peripheral blood lymphocytes. (PubMed id 8222045)9 Vanden Heuvel J.P....Bell D.A. (Carcinogenesis 1993)
    1025. 2,3,7,8-tetrachlorodibenzo-p-dioxin increases reactive oxygen species production in human endothelial cells via induction of cytochrome P4501A1. (PubMed id 20171976)9 Kopf P.G. and Walker M.K. (Toxicol. Appl. Pharmacol. 2010)
    1026. Arsenite down-regulates cytochrome P450 1A1 at the transcriptional and posttranslational levels in human HepG2 cells. (PubMed id 20188822)9 Anwar-Mohamed A. and El-Kadi A.O. (amp 2010)
    1027. Chlorophyllin significantly reduces benzo[a]pyrene-DNA adduct formation and alters cytochrome P450 1A1 and 1B1 expression and EROD activity in normal human mammary epithelial cells. (PubMed id 19152381)9 Keshava C....Weston A. (Environ. Mol. Mutagen. 2009)
    1028. The environmental pollutant and carcinogen 3-nitrobenzanthrone induces cytochrome P450 1A1 and NAD(P)H:quinone oxidoreductase in rat lung and kidney, thereby enhancing its own genotoxicity. (PubMed id 18329153)9 StiborovA! M....Arlt V.M. (Toxicology 2008)
    1029. Analysis of CYP1A1 induction in single cells of urothelial cell populations by flow cytometry. (PubMed id 18797853)9 PlAPttner S....FAPllmann W. (Anal Bioanal Chem 2008)
    1030. Modulation of TCDD-mediated induction of cytochrome P450 1A1 by mercury, lead, and copper in human HepG2 cell line. (PubMed id 17889500)9 Korashy H.M. and El-Kadi A.O. (Toxicol In Vitro 2008)
    1031. A real-time fluorescence assay for measuring N-dealkylation. (PubMed id 17035601)9 Mayer R.T....Mayer G.E. (Drug Metab. Dispos. 2007)
    1032. Arecoline inhibits the 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced cytochrome P450 1A1 activation in human hepatoma cells. (PubMed id 17234337)9 Chang E.E....Tsou T.C. (J. Hazard. Mater. 2007)
    1033. Abundance of aryl hydrocarbon receptor potentiates benzo[a]pyrene-induced apoptosis in Hepa1c1c7 cells via CYP1A1 activation. (PubMed id 17433523)9 Chung J.Y....Kim J.M. (Toxicology 2007)
    1034. Generation of 'humanized' hCYP1A1_1A2_Cyp1a1/1a2(-/-) mouse line. (PubMed id 17560947)9 Dragin N....Nebert D.W. (Biochem. Biophys. Res. Commun. 2007)
    1035. Investigation of sanguinarine and chelerythrine effects on CYP1A1 expression and activity in human hepatoma cells. (PubMed id 16115718)9 ZdarilovA! A....DvorA!k Z. (Food Chem. Toxicol. 2006)
    1036. Increased cytochrome P4501B1 gene expression in peripheral leukocytes of municipal waste incinerator workers. (PubMed id 16098693)9 Hu S.W....Lin P. (Toxicol. Lett. 2006)
    1037. Kimchi and soybean pastes are risk factors of gastric cancer. (PubMed id 15929164)9 Nan H.M....Kim H. (World J. Gastroenterol. 2005)
    1038. Association of CYP1A1 polymorphisms with differential metabolic activation of 17beta-estradiol and estrone. (PubMed id 15805301)9 Kisselev P....Schwarz D. (Cancer Res. 2005)
    1039. Significant association between nonsyndromic oral clefts and arylhydrocarbon receptor nuclear translocator (ARNT). (PubMed id 15368494)9 Kayano S....Matsubara Y. (Am. J. Med. Genet. A 2004)
    1040. Superinduction of CYP1A1 in MCF10A cultures by cycloheximide, anisomycin, and puromycin: a process independent of effects on protein translation and unrelated to suppression of aryl hydrocarbon receptor proteolysis by the proteasome. (PubMed id 15385644)9 Joiakim A....Reiners J.J. (Mol. Pharmacol. 2004)
    1041. AH receptor antagonist inhibits constitutive CYP1A1 and CYP1B1 expression in rat BP8 cells. (PubMed id 15047159)9 Roblin S....Harper P.A. (Biochem. Biophys. Res. Commun. 2004)
    1042. Methoxyestrogens exert feedback inhibition on cytochrome P450 1A1 and 1B1. (PubMed id 12810639)9 Dawling S....Parl F.F. (Cancer Res. 2003)
    1043. Effects of histone deacetylation and DNA methylation on the constitutive and TCDD-inducible expressions of the human CYP1 family in MCF-7 and HeLa cells. (PubMed id 12927368)9 Nakajima M....Yokoi T. (Toxicol. Lett. 2003)
    1044. Effect of TCDD exposure on CYP1A1 and CYP1B1 expression in explant cultures of human endometrium. (PubMed id 11452143)9 Bofinger D.P....Olson J.R. (Toxicol. Sci. 2001)
    1045. Increased expression of cytochrome p450 1A1 and 1B1 genes in anti-estrogen-resistant human breast cancer cell lines. (PubMed id 11093812)9 Brockdorff B.L....Lykkesfeldt A.E. (Int. J. Cancer 2000)
    1046. N,N-diethyl-2-[4-(phenylmethyl)phenoxy] ethanamine (DPPE) a chemopotentiating and cytoprotective agent in clinical trials: interaction with histamine at cytochrome P450 3A4 and other isozymes that metabolize antineoplastic drugs. (PubMed id 10755318)9 Brandes L.J....LaBella F.S. (Cancer Chemother. Pharmacol. 2000)
    1047. Genetic polymorphism of drug-metabolizing enzymes and susceptibility to oral cancer. (PubMed id 10506106)9 Sato M....Amagasa T. (Carcinogenesis 1999)
    1048. Polymorphism in cytochrome P450 CYP2D6, CYP1A1, CYP2E1 and glutathione S-transferase, GSTM1, GSTM3, GSTT1 and susceptibility to tobacco-related cancers: studies in upper aerodigestive tract cancers. (PubMed id 10022746)9 Matthias C....Strange R.C. (Pharmacogenetics 1998)
    1049. Comparative inhibition of human cytochromes P450 1A1 and 1A2 by flavonoids. (PubMed id 9763404)9 Zhai S....Vestal R.E. (Drug Metab. Dispos. 1998)
    1050. Cell-specific differences in the susceptibility of potential cellular targets of human origin derived from blood and lung following treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). (PubMed id 9538942)9 Lang D.S....Koren H.S. (Cell Biol. Toxicol. 1998)
    1051. Expression of CYP1B1 in human adult and fetal tissues and differential inducibility of CYP1B1 and CYP1A1 by Ah receptor ligands in human placenta and cultured cells. (PubMed id 9054634)9 Hakkola J....Raunio H. (Carcinogenesis 1997)
    1052. Polymorphisms of CYP1A1 and GSTM1 influence the in vivo function of CYP1A2. (PubMed id 9202749)9 MacLeod S....Lang N.P. (Mutat. Res. 1997)
    1053. Downregulation of aryl hydrocarbon receptor function and cytochrome P450 1A1 induction by expression of Ha-ras oncogenes. (PubMed id 9210956)9 Reiners J.J....Elferink C. (Mol. Carcinog. 1997)
    1054. Human Ah receptor (AHR) gene: localization to 7p15 and suggestive correlation of polymorphism with CYP1A1 inducibility. (PubMed id 9170146)9 Micka J....Nebert D.W. (Pharmacogenetics 1997)
    1055. Germ line polymorphisms in cytochrome-P450 1A1 (C4887 CYP1A1) and methylenetetrahydrofolate reductase (MTHFR) genes and endometrial cancer susceptibility. (PubMed id 9450474)9 Esteller M....Reventos J. (Carcinogenesis 1997)
    1056. Development of a human lymphoblastoid cell line constitutively expressing human CYP1B1 cDNA: substrate specificity with model substrates and promutagens. (PubMed id 9106248)9 Crespi C.L....Sutter T.R. (Mutagenesis 1997)
    1057. Frequency of mutant CYP1A1, NAT2 and GSTM1 alleles in normal Indians and Malays. (PubMed id 8563767)9 Zhao B....Gong N.H. (Pharmacogenetics 1995)
    1058. An inhibitory monoclonal anti-protein antibody and an anti-peptide antibody share an epitope on rat cytochrome P-450 enzymes CYP1A1 and CYP1A2. (PubMed id 7678502)9 Edwards R.J....Boobis A.R. (Biochim. Biophys. Acta 1993)
    1059. Stimulatory effect of the CYP1A1 inducer 2,3,7,8-tetrachlorodibenzo-p-dioxin on the reproduction of HIV-1 in human lymphoid cell culture. (PubMed id 7687806)9 Tsyrlov I.B. and Pokrovsky A. ( the fate of foreign compounds in biological systems 1993)
    1060. Mechanism of action of aryl hydrocarbon receptor antagonists: inhibition of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced CYP1A1 gene expression. (PubMed id 1329656)9 Merchant M....Safe S. (Arch. Biochem. Biophys. 1992)
    1061. Localization of CYP1A1 and CYP1A2 messenger RNA in normal human liver and in hepatocellular carcinoma by in situ hybridization. (PubMed id 1657755)9 McKinnon R.A....McManus M.E. (Hepatology 1991)
    1062. Pulmonary drug-metabolizing enzyme in alveolar macrophages in relation to cigarette smoking. (PubMed id 2232364)9 Abe S....Kawakami Y. (Jpn. J. Med. 1990)
    1063. Analysis of human CYP1A1 and CYP1A2 genes and their shared bidirectional promoter in eight world populations. (PubMed id 19802894)9 Jorge-Nebert L.F....Nebert D.W. (Hum. Mutat. 2010)
    1064. Augmentation of 3-methylcholanthrene-induced bioactivation in the human hepatoma cell line HepG2 by the calcium channel blocker nicardipine. (PubMed id 20067464)9 Hosaka T....Degawa M. (Cancer Sci. 2010)
    1065. Cytochrome P450 1A1 gene regulation by UVB involves crosstalk between the aryl hydrocarbon receptor and nuclear factor kappaB. (PubMed id 20132803)9 Luecke S....Rannug A. (Chem. Biol. Interact. 2010)
    1066. 2,3,7,8-Tetrachlorodibenzo-p-dioxin and beta-naphthoflavone induce cellular hypertrophy in H9c2 cells by an aryl hydrocarbon receptor-dependant mechanism. (PubMed id 19969063)9 Zordoky B.N. and El-Kadi A.O. (Toxicol In Vitro 2010)
    1067. Estrogen receptor subtype- and promoter-specific modulation of aryl hydrocarbon receptor-dependent transcription. (PubMed id 19470599)9 WihlAcn B....Matthews J. (Mol. Cancer Res. 2009)
    1068. HDAC6 modulates Hsp90 chaperone activity and regulates activation of aryl hydrocarbon receptor signaling. (PubMed id 19158084)9 Kekatpure V.D....Subbaramaiah K. (J. Biol. Chem. 2009)
    1069. Role of human CYP1A1 and NAT2 in 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced mutagenicity and DNA adducts. (PubMed id 19301197)9 Bendaly J....Hein D.W. ( the fate of foreign compounds in biological systems 2009)
    1070. Ascorbic acid suppresses the 2,3,7,8-tetrachloridibenxo-p-dioxin (TCDD)-induced CYP1A1 expression in human HepG2 cells. (PubMed id 19268519)9 Chang H.J....Jung Y.D. (Toxicol In Vitro 2009)
    1071. Persistent induction of cytochrome P450 (CYP)1A enzymes by 3-methylcholanthrene in vivo in mice is mediated by sustained transcriptional activation of the corresponding promoters. (PubMed id 19900403)9 Jiang W....Moorthy B. (Biochem. Biophys. Res. Commun. 2009)
    1072. Resveratrol inhibits dioxin-induced expression of human CYP1A1 and CYP1B1 by inhibiting recruitment of the aryl hydrocarbon receptor complex and RNA polymerase II to the regulatory regions of the corresponding genes. (PubMed id 19376845)9 Beedanagari S.R....Hankinson O. (Toxicol. Sci. 2009)
    1073. Potent inhibition of human cytochrome P450 1B1 by tetramethoxystilbene. (PubMed id 19463925)9 Chun Y.J....Kim M.Y. (Toxicol. Lett. 2009)
    1074. Expression of AhR, CYP1A1, GSTA1, c-fos and TGF-alpha in skin lesions from dioxin-exposed humans with chloracne. (PubMed id 18329192)9 Tang N.J....Bai Z.P. (Toxicol. Lett. 2008)
    1075. In vitro biotransformation of imatinib by the tumor expressed CYP1A1 and CYP1B1. (PubMed id 18188833)9 Rochat B....Michielin O. (amp 2008)
    1076. JNK inhibitor SP600125 is a partial agonist of human aryl hydrocarbon receptor and induces CYP1A1 and CYP1A2 genes in primary human hepatocytes. (PubMed id 17959153)9 Dvorak Z....Ulrichova J. (Biochem. Pharmacol. 2008)
    1077. Cobaltous chloride and hypoxia inhibit aryl hydrocarbon receptor-mediated responses in breast cancer cells. (PubMed id 17599377)9 Khan S....Safe S. (Toxicol. Appl. Pharmacol. 2007)
    1078. Differential effect of arecoline on the endogenous dioxin-responsive cytochrome P450 1A1 and on a stably transfected dioxin-responsive element-driven reporter in human hepatoma cells. (PubMed id 17707585)9 Chao H.R....Tsou T.C. (J. Hazard. Mater. 2007)
    1079. The anticancer drug ellipticine is a potent inducer of rat cytochromes P450 1A1 and 1A2, thereby modulating its own metabolism. (PubMed id 17656468)9 AimovA! D....StiborovA! M. (Drug Metab. Dispos. 2007)
    1080. 3-Methylcholanthrene elicits DNA adduct formation in the CYP1A1 promoter region and attenuates reporter gene expression in rat H4IIE cells. (PubMed id 17276403)9 Moorthy B....Jiang W. (Biochem. Biophys. Res. Commun. 2007)
    1081. Growth kinetics in MCF-7 cells modulate benzo[a]pyrene-induced CYP1A1 up-regulation. (PubMed id 17237483)9 Jiao H....Martin F.L. (Mutagenesis 2007)
    1082. Biotransformation of metamitron by human p450 expressed in transgenic tobacco cell cultures. (PubMed id 16484082)9 Bode M....Schmidt B. (J Environ Sci Health B 2006)
    1083. The expression of xenobiotic-metabolizing enzymes in human prostate and in prostate epithelial cells (PECs) derived from primary cultures. (PubMed id 16496416)9 Al-Buheissi S.Z....Phillips D.H. (Prostate 2006)
    1084. For dioxin-induced birth defects, mouse or human CYP1A2 in maternal liver protects whereas mouse CYP1A1 and CYP1B1 are inconsequential. (PubMed id 16636061)9 Dragin N....Nebert D.W. (J. Biol. Chem. 2006)
    1085. Duplicate aryl hydrocarbon receptor repressor genes (ahrr1 and ahrr2) in the zebrafish Danio rerio: structure, function, evolution, and AHR-dependent regulation in vivo. (PubMed id 16122694)9 Evans B.R....Hahn M.E. (Arch. Biochem. Biophys. 2005)
    1086. 5,7-Dimethoxyflavone downregulates CYP1A1 expression and benzo[a]pyrene-induced DNA binding in Hep G2 cells. (PubMed id 15661813)9 Wen X....Walle T. (Carcinogenesis 2005)
    1087. Effects of zearalenone on mRNA expression and activity of cytochrome P450 1A1 and 1B1 in MCF-7 cells. (PubMed id 15157572)9 Yu Z....Li Y. (Ecotoxicol. Environ. Saf. 2004)
    1088. Fluorinated 2-(4-amino-3-methylphenyl)benzothiazoles induce CYP1A1 expression, become metabolized, and bind to macromolecules in sensitive human cancer cells. (PubMed id 15355884)9 Brantley E....Stinson S.F. (Drug Metab. Dispos. 2004)
    1089. Occupational exposure to polycyclic aromatic hydrocarbons suppresses constitutive expression of CYP1B1 on the transcript level in human leukocytes. (PubMed id 15471096)9 Lemm F....Roos P.H. (Int J Hyg Environ Health 2004)
    1090. Suppression by p38 MAP kinase inhibitors (pyridinyl imidazole compounds) of Ah receptor target gene activation by 2,3,7,8-tetrachlorodibenzo-p-dioxin and the possible mechanism. (PubMed id 14594946)9 Shibazaki M....Kikuchi H. (J. Biol. Chem. 2004)
    1091. Modulation of AhR-mediated CYP1A1 mRNA and EROD activities by 17beta-estradiol and dexamethasone in TCDD-induced H411E cells. (PubMed id 14691211)9 Lai K.P....Wong C.K. (Toxicol. Sci. 2004)
    1092. Resveratrol inhibits TCDD-induced expression of CYP1A1 and CYP1B1 and catechol estrogen-mediated oxidative DNA damage in cultured human mammary epithelial cells. (PubMed id 15142886)9 Chen Z.H....Surh Y.J. (Carcinogenesis 2004)
    1093. Increased expression of cytochrome P4501B1 in peripheral leukocytes from lung cancer patients. (PubMed id 15093676)9 Wu M.F....Lin P. (Toxicol. Lett. 2004)
    1094. Sensitivity of renal cell carcinoma to aminoflavone: role of CYP1A1. (PubMed id 15017268)9 Loaiza-PAcrez A.I....Vistica D.T. (J. Urol. 2004)
    1095. Role of aryl hydrocarbon receptor-mediated induction of the CYP1 enzymes in environmental toxicity and cancer. (PubMed id 15028720)9 Nebert D.W....Gonzalez F.J. (J. Biol. Chem. 2004)
    1096. Real-time polymerase chain reaction analysis of CYP1B1 gene expression in human liver. (PubMed id 12520071)9 Chang T.K....Bandiera S.M. (Toxicol. Sci. 2003)
    1097. Estrogen regulates Ah responsiveness in MCF-7 breast cancer cells. (PubMed id 12970067)9 Spink D.C....Spink B.C. (Carcinogenesis 2003)
    1098. Quantitative analysis of the Ah receptor/cytochrome P450 CYP1B1/CYP1A1 signalling pathway. (PubMed id 12754102)9 McFadyen M.C....Murray G.I. (Biochem. Pharmacol. 2003)
    1099. Aryl hydrocarbon receptor mediates sensitivity of MCF-7 breast cancer cells to antitumor agent 2-(4-amino-3-methylphenyl) benzothiazole. (PubMed id 11752201)9 Loaiza-PAcrez A.I....Sausville E.A. (Mol. Pharmacol. 2002)
    1100. Differential regulation of expression of hepatic and pulmonary cytochrome P4501A enzymes by 3-methylcholanthrene in mice lacking the CYP1A2 gene. (PubMed id 12438513)9 Kondraganti S.R....Moorthy B. (J. Pharmacol. Exp. Ther. 2002)
    1101. The redox protein thioredoxin-1 regulates the constitutive and inducible expression of the estrogen metabolizing cytochromes P450 1B1 and 1A1 in MCF-7 human breast cancer cells. (PubMed id 12376470)9 Husbeck B. and Powis G. (Carcinogenesis 2002)
    1102. Differential inhibition of human CYP1A1 and CYP1A2 by quinidine and quinine. (PubMed id 11765139)9 Ching M.S....Ghabrial H. ( the fate of foreign compounds in biological systems 2001)
    1103. Low synthesis of retinoic acid due to impaired cytochrome P450 1a1 expression in mouse xeroderma pigmentosum fibroblasts. (PubMed id 11378441)9 Ding J....Ichikawa Y. (amp 2001)
    1104. 2,3,7,8-Tetrachlorodibenzo-p-dioxin and diindolylmethanes differentially induce cytochrome P450 1A1, 1B1, and 19 in H295R human adrenocortical carcinoma cells. (PubMed id 11294972)9 Sanderson J.T....van den Berg M. (Toxicol. Sci. 2001)
    1105. Induction and regulation of the carcinogen-metabolizing enzyme CYP1A1 by marijuana smoke and delta (9)-tetrahydrocannabinol. (PubMed id 11245634)9 Roth M.D....Hankinson O. (Am. J. Respir. Cell Mol. Biol. 2001)
    1106. Regulation of Cyp1a1 induction by dioxin as a function of cell cycle phase. (PubMed id 11602686)9 Santini R.P....Reiners J.J. (J. Pharmacol. Exp. Ther. 2001)
    1107. Polymorphisms of human aryl hydrocarbon receptor (AhR) gene in a French population: relationship with CYP1A1 inducibility and lung cancer. (PubMed id 11698344)9 Cauchi S.... Massaad-Massade L. (Carcinogenesis 2001)
    1108. Induction of cytochrome P450 1A1 gene expression, oxidative stress, and genotoxicity by carbaryl and thiabendazole in transfected human HepG2 and lymphoblastoid cells. (PubMed id 11226373)9 Delescluse C....Rahmani R. (Biochem. Pharmacol. 2001)
    1109. Is CYP1A1 induction always related to AHR signaling pathway? (PubMed id 11090948)9 Delescluse C....Rahmani R. (Toxicology 2000)
    1110. Influence of genetic susceptibility on the urinary excretion of 8-hydroxydeoxyguanosine of firefighters. (PubMed id 10810125)9 Hong Y.C....Ha E.H. (Occup Environ Med 2000)
    1111. Inhibitory effects of amiodarone and its N-deethylated metabolite on human cytochrome P450 activities: prediction of in vivo drug interactions. (PubMed id 10718780)9 Ohyama K....Yokoi T. (Br J Clin Pharmacol 2000)
    1112. Gender differences in genetic susceptibility for lung cancer. (PubMed id 11137199)9 Dresler C.M....Clapper M.L. (Lung Cancer 2000)
    1113. Estrogen enhances induction of cytochrome P-4501A1 by 2,3,7, 8-tetrachlorodibenzo-p-dioxin in liver of female Long-Evans rats. (PubMed id 10601559)9 Sarkar S....Sone H. (Int. J. Oncol. 2000)
    1114. Comparative effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on MCF-7, RL95-2, and LNCaP cells: role of target steroid hormones in cellular responsiveness to CYP1A1 induction. (PubMed id 11281733)9 Jana N.R....Sone H. (Mol. Cell Biol. Res. Commun. 2000)
    1115. Induction and regulation of xenobiotic-metabolizing cytochrome P450s in the human A549 lung adenocarcinoma cell line. (PubMed id 10696073)9 Hukkanen J....Raunio H. (Am. J. Respir. Cell Mol. Biol. 2000)
    1116. 2,3,7,8 Tetrachlorodibenzo-p-dioxin induction of cytochrome P4501A in cultured rat and human hepatocytes. (PubMed id 10728777)9 Xu L....Ruh M.F. (Chem. Biol. Interact. 2000)
    1117. Expression of dioxin-related transactivating factors and target genes in human eutopic endometrial and endometriotic tissues. (PubMed id 10764452)9 Bulun S.E....Kilic G. (Am. J. Obstet. Gynecol. 2000)
    1118. [Applications of aryl hydrocarbon hydroxylase in diagnosis of lung cancer]. (PubMed id 11778487)9 Chen L. and Liu Y. (Zhonghua Jie He He Hu Xi Za Zhi 2000)
    1119. Cytochrome P-450 1A1 expression in human small bowel: interindividual variation and inhibition by ketoconazole. (PubMed id 10064566)9 Paine M.F....Watkins P.B. (Drug Metab. Dispos. 1999)
    1120. Genetic cancer susceptibility and DNA adducts: studies in smokers, tobacco chewers, and coke oven workers. (PubMed id 10571654)9 Bartsch H....Alexandrov K. (Cancer Detect. Prev. 1999)
    1121. Genetic polymorphism of xenobiotic metabolizing enzymes among Chinese lung cancer patients. (PubMed id 10209943)9 Persson I....Ingelman-Sundberg M. (Int. J. Cancer 1999)
    1122. Ethnic susceptibility to lung cancer: differences in CYP2E1, CYP1A1 and GSTM1 genetic polymorphisms between French Caucasian and Chilean populations. (PubMed id 10454258)9 QuiA+ones L....Lucas D. (Cancer Lett. 1999)
    1123. Quercetin inhibits benzo[a]pyrene-induced DNA adducts in human Hep G2 cells by altering cytochrome P-450 1A1 gene expression. (PubMed id 10693172)9 Kang Z.C....Lee H. (Nutr Cancer 1999)
    1124. Effects of genetic polymorphism of metabolic enzymes, nutrition, and lifestyle factors on DNA adduct formation in lymphocytes. (PubMed id 9810147)9 Wang Y....Tomokuni K. (Ind Health 1998)
    1125. Glutathione S-transferase M1 and T1 and cytochrome P4501A1 polymorphisms in relation to the risk for benign and malignant head and neck lesions. (PubMed id 9486585)9 Oude Ophuis M.B....Manni J.J. (Cancer 1998)
    1126. Contribution of human hepatic cytochrome P450 isoforms to regioselective hydroxylation of steroid hormones. (PubMed id 9667077)9 Niwa T....Katagiri M. ( the fate of foreign compounds in biological systems 1998)
    1127. Genetic polymorphisms of CYP2D6, CYP1A1 and CYP2E1 in the South-Amerindian population of Chile. (PubMed id 9731721)9 MuA+oz S....Chianale J. (Pharmacogenetics 1998)
    1128. Delayed ontogenesis of CYP1A2 in the human liver. (PubMed id 9490065)9 Sonnier M. and Cresteil T. (Eur. J. Biochem. 1998)
    1129. 2,3,7,8-Tetrachlorodibenzo-p-dioxin increases mRNA levels for interleukin-1beta, urokinase plasminogen activator, and tumor necrosis factor-alpha in human uterine endometrial adenocarcinoma RL95-2 cells. (PubMed id 9299508)9 Charles G.D. and Shiverick K.T. (Biochem. Biophys. Res. Commun. 1997)
    1130. Effect of transforming growth factor-beta1 on expression of aryl hydrocarbon receptor and genes of Ah gene battery: clues for independent down-regulation in A549 cells. (PubMed id 9145908)9 DAPhr O....Abel J. (Mol. Pharmacol. 1997)
    1131. Cytochrome P450 CYP1A1 MspI polymorphism and lung cancer susceptibility. (PubMed id 8877059)9 Xu X....Christiani D.C. (amp 1996)
    1132. Multiple cutaneous basal cell carcinomas: glutathione S-transferase (GSTM1, GSTT1) and cytochrome P450 (CYP2D6, CYP1A1) polymorphisms influence tumour numbers and accrual. (PubMed id 8824510)9 Lear J.T....Strange R.C. (Carcinogenesis 1996)
    1133. Expression of aryl hydrocarbon receptor (AhR) and aryl hydrocarbon receptor nuclear translocator (Arnt) in adult rabbits known to be non-responsive to cytochrome P-450 1A1 (CYP1A1) inducers. (PubMed id 9022676)9 Takahashi Y....Kamataki T. (Eur. J. Biochem. 1996)
    1134. Bioassay for determining 2,3,7,8-tetrachlorodibenzo-p-dioxin equivalents (TEs) in human hepatoma Hepg2 cells. (PubMed id 8920757)9 Wiebel F.J....Kiefer F. (Toxicol. Lett. 1996)
    1135. Constitutive and inducible expression of drug metabolizing enzymes in cultured human keratinocytes. (PubMed id 7756127)9 Vecchini F....Shroot B. (Br. J. Dermatol. 1995)
    1136. Dioxin-responsive genes: examination of dose-response relationships using quantitative reverse transcriptase-polymerase chain reaction. (PubMed id 8261464)9 Vanden Heuvel J.P....Bell D.A. (Cancer Res. 1994)
    1137. NAD(P)H:quinone oxidoreductase1 (DT diaphorase) specifically prevents the formation of benzo[a]pyrene quinone-DNA adducts generated by cytochrome P4501A1 and P450 reductase. (PubMed id 8078896)9 Joseph P. and Jaiswal A.K. (Proc. Natl. Acad. Sci. U.S.A. 1994)
    1138. Effects of cycloheximide on the induction of CYP1A1 gene expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in three human breast cancer cell lines. (PubMed id 8382112)9 Arellano L.O....Safe S. (Carcinogenesis 1993)
    1139. Metabolic cytochrome P450 genotypes and assessment of individual susceptibility to lung cancer. (PubMed id 1306126)9 Hirvonen A....Vainio H. (Pharmacogenetics 1992)
    1140. Detection and characterization of the Ah receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin in the human colon adenocarcinoma cell line LS180. (PubMed id 1654865)9 Harper P.A....Okey A.B. (Arch. Biochem. Biophys. 1991)
    1141. Expression of CYP1A1 gene in patients with lung cancer: evidence for cigarette smoke-induced gene expression in normal lung tissue and for altered gene regulation in primary pulmonary carcinomas. (PubMed id 2380990)9 McLemore T.L....Lubet R.A. (J. Natl. Cancer Inst. 1990)
    1142. Induction of cytochrome P(1)450 RNA and benzo[a]pyrene metabolism in primary human hepatocyte cultures with benzanthracene. (PubMed id 1700499)9 Monteith D.K....Strom S.C. (Toxicol. Appl. Pharmacol. 1990)
    1143. Evidence for ligand-mediated selective modulation of aryl hydrocarbon receptor activity. (PubMed id 19903824)9 Murray I.A....Perdew G.H. (Mol. Pharmacol. 2010)
    1144. Exposure of human skin to benzo[a]pyrene: role of CYP1A1 and aryl hydrocarbon receptor in oxidative stress generation. (PubMed id 20307623)9 Costa C....Melchini A. (Toxicology 2010)
    1145. Peganum harmala L. is a candidate herbal plant for preventing dioxin mediated effects. (PubMed id 19941261)9 El Gendy M.A....El-Kadi A.O. (Planta Med. 2010)
    1146. TSU-16, (Z)-3-[(2,4-dimethylpyrrol-5-yl)methylidenyl]-2-indolinone, is a potent activator of aryl hydrocarbon receptor and increases CYP1A1 and CYP1A2 expression in human hepatocytes. (PubMed id 20171196)9 Matsuoka-Kawano K....Yamazoe Y. (Chem. Biol. Interact. 2010)
    1147. Evaluation of cytochrome P450 1 (CYP1) and N-acetyltransferase 1 (NAT1) activities in HaCaT cells: implications for the development of in vitro techniques for predictive testing of contact sensitizers. (PubMed id 20036732)9 Bonifas J....BlAPmeke B. (Toxicol In Vitro 2010)
    1148. Activation of the aryl hydrocarbon receptor pathway enhances cancer cell invasion by upregulating the MMP expression and is associated with poor prognosis in upper urinary tract urothelial cancer. (PubMed id 19755661)9 Ishida M....Oya M. (Carcinogenesis 2010)
    1149. The suggested physiologic aryl hydrocarbon receptor activator and cytochrome P4501 substrate 6-formylindolo[3,2-b]carbazole is present in humans. (PubMed id 19054769)9 Wincent E....Rannug U. (J. Biol. Chem. 2009)
    1150. Inhibition of CYP1A1 by Quassinoids found in Picrasma excelsa. (PubMed id 19016402)9 Shields M....Delgoda R. (Planta Med. 2009)
    1151. TCDD-mediated suppression of the in vitro anti-sheep erythrocyte IgM antibody forming cell response is reversed by interferon-gamma. (PubMed id 18948302)9 North C.M....Kaminski N.E. (Toxicol. Sci. 2009)
    1152. Aryl hydrocarbon receptor pathway activation enhances gastric cancer cell invasiveness likely through a c-Jun-dependent induction of matrix metalloproteinase-9. (PubMed id 19371443)9 Peng T.L....Chen M.H. (BMC Cell Biol. 2009)
    1153. Repression of activated aryl hydrocarbon receptor-induced transcriptional activation by 5alpha-dihydrotestosterone in human prostate cancer LNCaP and human breast cancer T47D cells. (PubMed id 19270430)9 Sanada N....Kizu R. (J. Pharmacol. Sci. 2009)
    1154. [Metabolic activation of benzo(a)pyrene enhanced transformation of human bronchial epithelium cell HBETR]. (PubMed id 20047213)9 Pang Y....Chen W. (Wei Sheng Yan Jiu 2009)
    1155. Activation function 2 mediates dioxin-induced recruitment of estrogen receptor alpha to CYP1A1 and CYP1B1. (PubMed id 19460354)9 MacPherson L....Matthews J. (Biochem. Biophys. Res. Commun. 2009)
    1156. Modulation of carcinogen metabolism by nitric oxide-aspirin 2 is associated with suppression of DNA damage and DNA adduct formation. (PubMed id 19542225)9 MacDonald C.J....Yeh G.C. (J. Biol. Chem. 2009)
    1157. Evaluation of the transport, in vitro metabolism and pharmacokinetics of Salvinorin A, a potent hallucinogen. (PubMed id 19462483)9 Teksin Z.S....Eddington N.D. (Eur J Pharm Biopharm 2009)
    1158. Effects of dioxin on vascular endothelial growth factor (VEGF) production in the retina associated with choroidal neovascularization. (PubMed id 19182260)9 Takeuchi A....Kuroda M. (amp 2009)
    1159. Further assessment of 17alpha-ethinyl estradiol as an inhibitor of different human cytochrome P450 forms in vitro. (PubMed id 19454483)9 Chang S.Y....Rodrigues A.D. (Drug Metab. Dispos. 2009)
    1160. 3-aminobenzanthrone, a human metabolite of the carcinogenic environmental pollutant 3-nitrobenzanthrone, induces biotransformation enzymes in rat kidney and lung. (PubMed id 19398038)9 StiborovA! M....Arlt V.M. (Mutat. Res. 2009)
    1161. Cytochrome P450 CYP1A1: wider roles in cancer progression and prevention. (PubMed id 19531241)9 Androutsopoulos V.P....Spandidos D.A. (BMC Cancer 2009)
    1162. Up-regulation of the CYP1 family in rat and human liver by the aliphatic isothiocyanates erucin and sulforaphane. (PubMed id 18773935)9 Hanlon N....Ioannides C. (Toxicology 2008)
    1163. 2,3,7,8-Tetrachlorodibenzo-p-dioxin modulates the induction of DNA strand breaks and poly(ADP-ribose) polymerase-1 activation by 17beta-estradiol in human breast carcinoma cells through alteration of CYP1A1 and CYP1B1 expression. (PubMed id 18558727)9 Lin P.H....Chuang M.C. (Chem. Res. Toxicol. 2008)
    1164. Effect of long-term selenium yeast intervention on activity and gene expression of antioxidant and xenobiotic metabolising enzymes in healthy elderly volunteers from the Danish Prevention of Cancer by Intervention by Selenium (PRECISE) pilot study. (PubMed id 18062829)9 Ravn-Haren G....Dragsted L.O. (Br. J. Nutr. 2008)
    1165. Activation of the aryl hydrocarbon receptor by the calcium/calmodulin-dependent protein kinase kinase inhibitor 7-oxo-7H-benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylic acid (STO-609). (PubMed id 18755850)9 Monteiro P....Fardel O. (Drug Metab. Dispos. 2008)
    1166. Pyrethroids: cytotoxicity and induction of CYP isoforms in human hepatocytes. (PubMed id 19326768)9 Das P.C....Hodgson E. (Drug Metabol Drug Interact 2008)
    1167. Generation of a 'humanized' hCYP1A1_1A2_Cyp1a1/1a2(-/-)_Ahrd mouse line harboring the poor-affinity aryl hydrocarbon receptor. (PubMed id 18814841)9 Shi Z....Nebert D.W. (Biochem. Biophys. Res. Commun. 2008)
    1168. Tumor necrosis factor-alpha potentiates genotoxic effects of benzo[a]pyrene in rat liver epithelial cells through upregulation of cytochrome P450 1B1 expression. (PubMed id 18336843)9 UmannovA! L....VondrA!cek J. (Mutat. Res. 2008)
    1169. The aryl hydrocarbon receptor repressor is a putative tumor suppressor gene in multiple human cancers. (PubMed id 18172554)9 Zudaire E....Cuttitta F. (J. Clin. Invest. 2008)
    1170. A low halogenated biphenyl (PCB3) increases CYP1A1 expression and activity via the estrogen receptor beta in the porcine ovary. (PubMed id 18953099)9 Ptak A....Gregoraszczuk E.A.8. (J. Physiol. Pharmacol. 2008)
    1171. A novel synthetic analogue of a constituent of Isodon excisus inhibits transcription of CYP1A1, -1A2 and -1B1 by preventing activation of the aryl hydrocarbon receptor. (PubMed id 17183067)9 Sienkiewicz P....Yeh G.C. (Carcinogenesis 2007)
    1172. Chromium cross-links histone deacetylase 1-DNA methyltransferase 1 complexes to chromatin, inhibiting histone-remodeling marks critical for transcriptional activation. (PubMed id 17682057)9 Schnekenburger M....Puga A. (Mol. Cell. Biol. 2007)
    1173. The environmental carcinogen benzo[a]pyrene induces expression of monocyte-chemoattractant protein-1 in vascular tissue: a possible role in atherogenesis. (PubMed id 17376491)9 Knaapen A.M....Van Schooten F.J. (Mutat. Res. 2007)
    1174. Cytochrome P450 expression (CYP) in non-small cell lung cancer. (PubMed id 17127240)9 Oyama T....Yasumoto K. (Front. Biosci. 2007)
    1175. Identification of a novel co-transcription of P450/1A1 with telomerase in A549. (PubMed id 17141429)9 Shervington A....Lea R. (Gene 2007)
    1176. A possible role for dihydrodiol dehydrogenase in the formation of benzo[a]pyrene-DNA adducts in lung cancer cells and tumor tissues. (PubMed id 17163506)9 Cheng Y.W....Lee H. (Environ. Mol. Mutagen. 2007)
    1177. Cyclooxygenase-2 promoter activation by the aromatic hydrocarbon receptor in breast cancer mcf-7 cells: repressive effects of conjugated linoleic acid. (PubMed id 18001219)9 Degner S.C....Romagnolo D.F. (Nutr Cancer 2007)
    1178. Eugenol inhibit 7,12-dimethylbenz[a]anthracene-induced genotoxicity in MCF-7 cells: Bifunctional effects on CYP1 and NAD(P)H:quinone oxidoreductase. (PubMed id 17275817)9 Han E.H....Jeong H.G. (FEBS Lett. 2007)
    1179. A dioxin-responsive enhancer 3' of the human CYP1A2 gene. (PubMed id 17785579)9 Okino S.T....Dahiya R. (Mol. Pharmacol. 2007)
    1180. Cytochrome P450 gene induction in rats ex vivo assessed by quantitative real-time reverse transcriptase-polymerase chain reaction (TaqMan). (PubMed id 16531474)9 Baldwin S.J....Clarke S.E. (Drug Metab. Dispos. 2006)
    1181. Inhibition of benzo[a]pyrene-activating enzymes and DNA binding in human bronchial epithelial BEAS-2B cells by methoxylated flavonoids. (PubMed id 16484233)9 Tsuji P.A. and Walle T. (Carcinogenesis 2006)
    1182. Influence of glutathione-S-transferase (GSTM1, GSTP1, GSTT1) and cytochrome p450 (CYP1A1, CYP2D6) polymorphisms on numbers of basal cell carcinomas (BCCs) in families with the naevoid basal cell carcinoma syndrome. (PubMed id 16582078)9 R Yang X....Goldstein A.M. (J. Med. Genet. 2006)
    1183. Naphthalene toxicity in mice and aryl hydrocarbon receptor-mediated CYPs. (PubMed id 16876762)9 Genter M.B....Nebert D.W. (Biochem. Biophys. Res. Commun. 2006)
    1184. TCDD-induced CYP1A1 expression, an index of dioxin toxicity, is suppressed by flavonoids permeating the human intestinal Caco-2 cell monolayers. (PubMed id 17090139)9 Hamada M....Shimizu M. (J. Agric. Food Chem. 2006)
    1185. Arsenic inhibits induction of cytochrome P450 1A1 by 2,3,7,8-tetrachlorodibenzo-p-dioxin in human hepatoma cells. (PubMed id 16713074)9 Chao H.R....Lee W.J. (J. Hazard. Mater. 2006)
    1186. Preferential induction of CYP1A1 and CYP1B1 in CCSP-positive cells. (PubMed id 16237193)9 Chang H....Lin P. (Toxicol. Sci. 2006)
    1187. Oxidative metabolism of the alkaloid rutaecarpine by human cytochrome P450. (PubMed id 16501007)9 Ueng Y.F....Chen C.F. (Drug Metab. Dispos. 2006)
    1188. Altered gene expression patterns in MCF-7 cells induced by the urban dust particulate complex mixture standard reference material 1649a. (PubMed id 15735009)9 Mahadevan B....Baird W.M. (Cancer Res. 2005)
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