Aliases for CYP1A1 Gene
Aliases for CYP1A1 Gene
- Cytochrome P450 Family 1 Subfamily A Member 1 2 3 5
- Cytochrome P450, Subfamily I (Aromatic Compound-Inducible), Polypeptide 1 2 3
- Cytochrome P450, Family 1, Subfamily A, Polypeptide 1 2 3
- Cytochrome P450 Form 6 3 4
- Cytochrome P450-P1 3 4
- Cytochrome P450-C 3 4
- EC 1.14.14.1 4 61
- CYPIA1 3 4
- Cytochrome P1-450, Dioxin-Inducible 3
- Flavoprotein-Linked Monooxygenase 3
- Aryl Hydrocarbon Hydroxylase 3
External Ids for CYP1A1 Gene
- HGNC: 2595
- Entrez Gene: 1543
- Ensembl: ENSG00000140465
- OMIM: 108330
- UniProtKB: P04798
Previous HGNC Symbols for CYP1A1 Gene
- CYP1
Previous GeneCards Identifiers for CYP1A1 Gene
- GC15M068848
- GC15M068126
- GC15M072587
- GC15M072727
- GC15M072798
- GC15M075011
- GC15M051809
Summaries for CYP1A1 Gene
-
This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2016]
GeneCards Summary for CYP1A1 Gene
CYP1A1 (Cytochrome P450 Family 1 Subfamily A Member 1) is a Protein Coding gene. Diseases associated with CYP1A1 include Ehrlich Tumor Carcinoma and Lung Squamous Cell Carcinoma. Among its related pathways are Cytochrome P450 - arranged by substrate type and Estrogen metabolism. GO annotations related to this gene include enzyme binding and iron ion binding. An important paralog of this gene is CYP1A2.
UniProtKB/Swiss-Prot for CYP1A1 Gene
-
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYP1A1 Gene
Genomics for CYP1A1 Gene
Regulatory Elements for CYP1A1 Gene
Enhancers for CYP1A1 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around CYP1A1 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the CYP1A1 gene promoter:
Regulatory Element Products
Genomic Location for CYP1A1 Gene
- Chromosome:
- 15
- Start:
- 74,719,542 bp from pter
- End:
- 74,725,610 bp from pter
- Size:
- 6,069 bases
- Orientation:
- Minus strand
Genomic View for CYP1A1 Gene
Genes around CYP1A1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 15q24.1 by Ensembl
- 15q24.1 by Entrez Gene
- 15q24.1 by HGNC
CYP1A1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CYP1A1 Gene
Proteins for CYP1A1 Gene
-
Protein details for CYP1A1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P04798-CP1A1_HUMAN
- Recommended name:
- Cytochrome P450 1A1
- Protein Accession:
- P04798
- A4F3V9
- A4F3W0
- Q53G18
Protein attributes for CYP1A1 Gene
- Size:
- 512 amino acids
- Molecular mass:
- 58165 Da
- Cofactor:
- Name=heme; Xref=ChEBI:CHEBI:30413;
- Quaternary structure:
- No Data Available
Protein Expression for CYP1A1 Gene
Selected DME Specific Peptides for CYP1A1 Gene
- P04798:
-
- KEHYKTFEKG
- TTAISWSL
- FSIASDP
- QGDDFKGRP
- CVFVNQWQ
- VLSGLDTIRQALV
- PILRYLP
- LDENANVQ
- ELDTVIG
- SGNPADFIPIL
- EVFLFLA
- QLSDEKI
- NVICAICFG
- VVGSGNPADFIP
- NQWQINH
- PFTIPHST
- RRPRLSDR
- LTLGKNPH
- TPIYGLT
- PHSTTRDT
- IRDITDSLI
- YGDVLQI
- WAARRRLAQ
- FGAGFDT
- LPYMEAFILE
Post-translational modifications for CYP1A1 Gene
Other Protein References for CYP1A1 Gene
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for CYP1A1
- Novus Biologicals Antibodies for CYP1A1
-
Cloud-Clone Corp. Antibodies for CYP1A1
- Invitrogen Antibodies for CYP1A1
- antibodies-online Antibodies for CYP1A1: See all 133
- GeneTex CYP1A1 antibody for CYP1A1
-
Santa Cruz Biotechnology (SCBT) Antibodies for CYP1A1
Protein Products
-
OriGene Purified Proteins for CYP1A1
- Search Origene for MassSpec and Protein Over-expression Lysates for CYP1A1
- Origene Custom Protein Services for CYP1A1
-
Cloud-Clone Corp. Proteins for CYP1A1
- antibodies-online Proteins for CYP1A1: See all 11
- Search antibodies-online for peptides
- Search GeneTex for Proteins for CYP1A1
Domains & Families for CYP1A1 Gene
Gene Families for CYP1A1 Gene
- HGNC:
- IUPHAR :
Protein Domains for CYP1A1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for CYP1A1 Gene
Graphical View of Domain Structure for InterPro Entry
P04798- Family:
-
- Belongs to the cytochrome P450 family.
Function for CYP1A1 Gene
Molecular function for CYP1A1 Gene
- GENATLAS Biochemistry:
- cytochrome p450,family I (polycytic aromatic compound-inducible),member A1 (see CYP1@),associated with susceptibility to lung squamous cell carcinoma and to childhood acute lymphoblastic leukemia (in association with deletion of GSTM1)
- UniProtKB/Swiss-Prot CatalyticActivity:
- RH + [reduced NADPH--hemoprotein reductase] + O(2) = ROH + [oxidized NADPH--hemoprotein reductase] + H(2)O.
- UniProtKB/Swiss-Prot Function:
- Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
- UniProtKB/Swiss-Prot Induction:
- By 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).
Enzyme Numbers (IUBMB) for CYP1A1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003824 | catalytic activity | IEA | -- |
| GO:0004497 | monooxygenase activity | TAS,IEA | -- |
| GO:0005506 | iron ion binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 25416956 |
| GO:0008395 | steroid hydroxylase activity | IEA | -- |
Phenotypes for CYP1A1 Gene
- MGI mutant phenotypes for CYP1A1:
- inferred from 6 alleles
- GenomeRNAi human phenotypes for CYP1A1:
-
- Increased viability
- Increased vaccinia virus (VACV) infection
- Decreased viability
- Mildly decreased CFP-tsO45G cell surface transport
- Decreased NF-kappaB reporter expression
- Increased transferrin (TF) endocytosis
- Negative genetic interaction between PTEN-/- and PTEN+/+
- Weakly decreased NFAT1-GFP nuclear translocation
- Increased shRNA abundance
Animal Models for CYP1A1 Gene
- MGI Knock Outs for CYP1A1:
-
- Cyp1a1 tm1.1Dwn
- Cyp1a2/Cyp1a1 tm1.1Bra
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for CYP1A1
-
-
ViGene Biosciences lentiviral particle packaged cDNA for CYP1A1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CYP1A1 gene
- Search ViGene Biosciences for CYP1A1
CRISPR Products
-
OriGene CRISPR knockouts for CYP1A1
-
Santa Cruz Biotechnology (SCBT) CRISPR for CYP1A1
- GenScript: Design CRISPR guide RNA sequences for CYP1A1
miRNA for CYP1A1 Gene
- miRTarBase miRNAs that target CYP1A1
-
- hsa-mir-296-3p (MIRT038448)
- hsa-mir-6809-3p (MIRT489671)
- hsa-mir-6833-3p (MIRT489672)
- hsa-mir-4768-5p (MIRT489673)
- hsa-mir-3191-5p (MIRT489674)
- hsa-mir-4294 (MIRT489675)
- hsa-mir-4680-5p (MIRT489676)
- hsa-mir-4679 (MIRT489677)
- hsa-mir-4677-3p (MIRT489678)
- hsa-mir-3664-5p (MIRT489679)
- hsa-mir-1231 (MIRT497714)
- hsa-mir-632 (MIRT497715)
- hsa-mir-6888-3p (MIRT497716)
- hsa-mir-4288 (MIRT497717)
- hsa-mir-155-5p (MIRT497718)
- hsa-mir-655-3p (MIRT497719)
- hsa-mir-374c-5p (MIRT497720)
- hsa-mir-3120-5p (MIRT497721)
- hsa-mir-892c-3p (MIRT497722)
- hsa-mir-4676-3p (MIRT497723)
- hsa-mir-452-5p (MIRT497724)
- hsa-mir-429 (MIRT497725)
- hsa-mir-200c-3p (MIRT497726)
- hsa-mir-8084 (MIRT497727)
- hsa-mir-200b-3p (MIRT497728)
miRNA Products
- Search ViGene Biosciences for CYP1A1
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CYP1A1
- Browse OriGene Inhibitory RNA Products For CYP1A1
-
ViGene Biosciences ready-to-package AAV shRNAs for CYP1A1 gene
Clone Products
-
OriGene ORF clones in human for CYP1A1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for CYP1A1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CYP1A1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CYP1A1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for CYP1A1
-
ViGene Biosciences adenoviral particle packaged cDNA for CYP1A1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for CYP1A1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CYP1A1 gene
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CYP1A1 Gene
Localization for CYP1A1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CYP1A1 Gene
- Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
| Compartment | Confidence |
|---|---|
| endoplasmic reticulum | 5 |
| mitochondrion | 3 |
| nucleus | 3 |
| plasma membrane | 2 |
| extracellular | 2 |
| peroxisome | 2 |
| cytosol | 2 |
| cytoskeleton | 1 |
| lysosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005739 | mitochondrion | IEA | -- |
| GO:0005783 | endoplasmic reticulum | IEA | -- |
| GO:0005789 | endoplasmic reticulum membrane | IEA,TAS | -- |
| GO:0016020 | membrane | IEA | -- |
Pathways & Interactions for CYP1A1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Cytochrome P450 - arranged by substrate type |
.39
|
|
| 2 | Drug metabolism - cytochrome P450 | ||
| 3 | Arachidonic acid metabolism | ||
| 4 | Metabolism |
.37
|
|
| 5 | Gefitinib Pathway, Pharmacokinetics | ||
Pathways by source for CYP1A1 Gene
12 BioSystems pathways for CYP1A1 Gene
12 Reactome pathways for CYP1A1 Gene
7 KEGG pathways for CYP1A1 Gene
7 GeneGo (Thomson Reuters) pathways for CYP1A1 Gene
Interacting Proteins for CYP1A1 Gene
Selected Interacting proteins:
ENSP00000369050
P04798-CP1A1_HUMAN
for CYP1A1 Gene via
STRING
IID
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001666 | response to hypoxia | IEA | -- |
| GO:0001889 | liver development | IEA | -- |
| GO:0002933 | lipid hydroxylation | IDA | 14559847 |
| GO:0006778 | porphyrin-containing compound metabolic process | IEA | -- |
| GO:0007568 | aging | IEA | -- |
No data available for SIGNOR curated interactions for CYP1A1 Gene
Drugs & Compounds for CYP1A1 Gene
(186) Drugs for CYP1A1 Gene - From: DrugBank, PharmGKB, ApexBio, FDA Approved Drugs, HMDB, and Novoseek
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Granisetron | Approved, Investigational | Pharma | Enzyme, substrate | Serotonin 5-HT3 receptor antagonist | 72 | |
| Phenobarbital | Approved | Pharma | Agonist, Enzyme, inducer | 59 | ||
| Chlorzoxazone | Approved | Pharma | Agonist, Activator, Enzyme, substrate | 7 | ||
| Clofibrate | Approved | Pharma | Agonist, Enzyme, inducer | 2 | ||
| Daunorubicin | Approved | Pharma | Enzyme, substrate | DNA topoisomerase II inhibitor | 273 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| 11,12,15-THETA |
|
|
||||
| 11,12-Epoxyeicosatrienoic acid |
|
81276-02-0 |
|
|||
| 11,14,15-THETA |
|
|
||||
| 11H-14,15-EETA |
|
219535-29-2 |
|
|||
| 12,13-EpOME |
|
|
(4) ApexBio Compounds for CYP1A1 Gene
| Compound | Action | Cas Number |
|---|---|---|
| 7-Ethoxyresorufin | Specific subtrate of CYP1A | 5725-91-7 |
| Diosmetin | CYP1A1 inhibitor | 520-34-3 |
| Methoxyresorufin | 5725-89-3 | |
| Pentoxyresorufin | 87687-03-4 |
Transcripts for CYP1A1 Gene
mRNA/cDNA for CYP1A1 Gene
- (4) REFSEQ mRNAs :
- (15) Additional mRNA sequences :
- (52) Selected AceView cDNA sequences:
- (10) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for CYP1A1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for CYP1A1
-
Santa Cruz Biotechnology (SCBT) CRISPR for CYP1A1
- GenScript: Design CRISPR guide RNA sequences for CYP1A1
miRNA Products
- Search ViGene Biosciences for CYP1A1
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CYP1A1
- Browse OriGene Inhibitory RNA Products For CYP1A1
-
ViGene Biosciences ready-to-package AAV shRNAs for CYP1A1 gene
Clone Products
-
OriGene ORF clones in human for CYP1A1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for CYP1A1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CYP1A1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CYP1A1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||
| SP2: |
Expression for CYP1A1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Adipose (Muscoskeletal System)
-
Lung (Respiratory System)
- Basal Cells Respiratory Bronchioles
-
Epithelial Cells
- Basal Cells Respiratory Bronchioles
-
Liver (Hepatobiliary System)
- Perivenous Hepatocytes Liver Lobule
- Intestine (Gastrointestinal Tract)
- Placenta (Extraembryonic Tissues)
mRNA differential expression in normal tissues according to GTEx for CYP1A1 Gene
This gene is overexpressed in Liver (x8.2), Lung (x5.5), Adipose - Subcutaneous (x5.0), and Skin - Sun Exposed (Lower leg) (x4.0).
This gene is overexpressed in Gallbladder (22.6), Liver (18.4), Plasma (12.0), Pancreatic juice (10.0), and Islet of Langerhans (6.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CYP1A1 Gene
NURSA nuclear receptor signaling pathways regulating expression of CYP1A1 Gene:
CYP1A1SOURCE GeneReport for Unigene cluster for CYP1A1 Gene:
Hs.72912mRNA Expression by UniProt/SwissProt for CYP1A1 Gene:
P04798-CP1A1_HUMAN
Tissue specificity:
Lung, lymphocytes and placenta.
Evidence on tissue expression from TISSUES for CYP1A1 Gene
- Liver(4.8)
- Blood(4.5)
- Nervous system(4.4)
- Lung(3.4)
- Intestine(2.8)
- Kidney(2.7)
- Skin(2.3)
Primer Products
-
OriGene qPCR primer pairs and template standards for CYP1A1
-
OriGene qPCR primer pairs for CYP1A1
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CYP1A1 Gene
Orthologs for CYP1A1 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CYP1A1 35 |
|
OneToOne | |
| LOC453744 34 |
|
||||
| cow (Bos Taurus) |
Mammalia | CYP1A1 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | CYP1A1 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Cyp1a1 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Cyp1a1 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | -- 35 |
|
ManyToMany | |
| -- 35 |
|
ManyToMany | |||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 35 |
|
OneToMany | |
| chicken (Gallus gallus) |
Aves | CYP1A1 34 35 |
|
||
| CYP1A4 35 |
|
ManyToMany | |||
| lizard (Anolis carolinensis) |
Reptilia | -- 35 |
|
ManyToMany | |
| -- 35 |
|
ManyToMany | |||
| -- 35 |
|
ManyToMany | |||
| tropical clawed frog (Silurana tropicalis) |
Amphibia | cyp1a1 34 |
|
||
| Str.2144 34 |
|
||||
| zebrafish (Danio rerio) |
Actinopterygii | cyp1a 34 35 |
|
||
| cyp1a1 34 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | Cyp18a1 36 |
|
|
|
| Cyp307a1 36 |
|
|
|||
| spo 35 |
|
ManyToMany | |||
| spok 35 |
|
ManyToMany | |||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | CYP93D1 34 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os06g0613600 34 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
ManyToMany | |
| -- 35 |
|
ManyToMany |
- Species where no ortholog for CYP1A1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for CYP1A1 Gene
(30) SIMAP similar genes for CYP1A1 Gene using alignment to 8 proteins:
Pseudogenes.org Pseudogenes for CYP1A1 Gene
Variants for CYP1A1 Gene
| SNP ID | Clin | Chr 15 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000393848 | -- | 74,719,252(+) | GTGCC(G/T)GCGGC | downstream-variant-500B | |
| rs1000699728 | -- | 74,724,009(+) | ATTGC(C/T)TTCAG | intron-variant | |
| rs1000751890 | -- | 74,723,694(+) | TCATG(G/T)TCTCA | intron-variant | |
| rs1001267801 | -- | 74,724,894(+) | CCTGG(G/T)ACTCC | intron-variant | |
| rs1001321488 | -- | 74,725,220(+) | CTGTA(C/T)CTAGA | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2763106 | CNV | loss | 21179565 |
| esv3636907 | CNV | loss | 21293372 |
| nsv1121512 | CNV | deletion | 24896259 |
| nsv817698 | CNV | gain | 17921354 |
| nsv833055 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
96.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
8.23;
84.97% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for CYP1A1 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CYP1A1 Gene
Disorders for CYP1A1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| ehrlich tumor carcinoma |
|
|
| lung squamous cell carcinoma |
|
|
| oral cavity cancer |
|
|
| basal cell carcinoma, multiple |
|
|
| squamous cell carcinoma |
|
Search CYP1A1 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for CYP1A1
No data available for UniProtKB/Swiss-Prot and Genatlas for CYP1A1 Gene
Publications for CYP1A1 Gene
- Polymorphisms in genes of the steroid hormone biosynthesis and metabolism pathways and endometrial cancer risk. (PMID: 20381444) Ashton K.A. … Scott R.J. (Cancer Epidemiol 2010) 3 22 46 64
- Genetic association study of CYP1A1 polymorphisms identifies risk haplotypes in nonsmall cell lung cancer. (PMID: 19608585) Wright C.M. … Fong K.M. (Eur. Respir. J. 2010) 3 22 46 64
- Effect of combined genetic polymorphisms on lung cancer risk in northern Thai women. (PMID: 19963114) Klinchid J. … Cressey R. (Cancer Genet. Cytogenet. 2009) 3 22 46 64
- Prevalence of CYP1A1 and GST polymorphisms in the population of northeastern India and susceptibility of oral cancer. (PMID: 19718946) Chatterjee S. … Talukder G. (Oncol. Res. 2009) 3 22 46 64
- Evidence for increased cytochrome P450 1A1 expression in blood lymphocytes of lung cancer patients. (PMID: 19632247) Shah P.P. … Parmar D. (Mutat. Res. 2009) 3 22 46 64
Products for CYP1A1 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
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- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for CYP1A1
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for CYP1A1
- Search Origene for MassSpec and Protein Over-expression Lysates for CYP1A1
- Origene Custom Protein Services for CYP1A1
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CYP1A1
- Browse OriGene Inhibitory RNA Products For CYP1A1
- OriGene qPCR primer pairs and template standards for CYP1A1
- OriGene qPCR primer pairs for CYP1A1
- OriGene CRISPR knockouts for CYP1A1
- OriGene ORF clones in human for CYP1A1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CYP1A1
- GenScript: Next-day shipping cDNA ORF clone for CYP1A1 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for CYP1A1
- GenScript Custom Assay Services for CYP1A1
- GenScript Custom overexpressing Cell Line Services for CYP1A1
- GenScript: Design CRISPR guide RNA sequences for CYP1A1
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for CYP1A1
- Sino Biological Human cDNA Clone for CYP1A1
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Proteins
- Sino Biological Antibodies
- Sino Biological ELISA Kits and Pair Sets
- Sino Biological Cell Lysates
- Sino Biological qPCR Primers
- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for CYP1A1
- Novus Biologicals proteins and lysates for CYP1A1
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Cloud-Clone Corp. Antibodies for CYP1A1
- Cloud-Clone Corp. Proteins for CYP1A1
- Cloud-Clone Corp Assay Kits for CYP1A1
- Invitrogen Antibodies for CYP1A1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- ApexBio compounds for CYP1A1
- antibodies-online Antibodies for CYP1A1: See all 133
- antibodies-online Kits for CYP1A1: See all 29
- antibodies-online Proteins for CYP1A1: See all 11
- Search antibodies-online for peptides
- GeneTex CYP1A1 antibody for CYP1A1
- Search GeneTex for Proteins for CYP1A1
- ViGene Biosciences adenoviral particle packaged cDNA for CYP1A1 gene
- ViGene Biosciences lentiviral particle packaged cDNA for CYP1A1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for CYP1A1 gene
- Search ViGene Biosciences for CYP1A1
- Santa Cruz Biotechnology (SCBT) Antibodies for CYP1A1
- Search Santa Cruz Biotechnology (SCBT) for CYP1A1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CYP1A1
- Horizon Cell Lines for CYP1A1
- Cyagen custom Knockout/knockin (KOKI) mouse models for CYP1A1
- VectorBuilder custom plasmid, inducible vectors for CYP1A1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CYP1A1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for CYP1A1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
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- (28) RNAdb
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- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
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- (115) ProteomicsDB
- (116) SCBT
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- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
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- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer