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CYP1A1 Gene(Protein Coding)

Cytochrome P450 Family 1 Subfamily A Member 1

GCID:
GC15M074719
GIFtS:
71
Genes Participants
UDN Logo

Aliases for CYP1A1 Gene

Aliases for CYP1A1 Gene

  • Cytochrome P450 Family 1 Subfamily A Member 1 2 3 5
  • Cytochrome P450, Subfamily I (Aromatic Compound-Inducible), Polypeptide 1 2 3
  • Cytochrome P450, Family 1, Subfamily A, Polypeptide 1 2 3
  • Cytochrome P450 Form 6 3 4
  • Cytochrome P450-P1 3 4
  • Cytochrome P450-C 3 4
  • EC 1.14.14.1 4 63
  • CYPIA1 3 4
  • Cytochrome P1-450, Dioxin-Inducible 3
  • Flavoprotein-Linked Monooxygenase 3
  • Aryl Hydrocarbon Hydroxylase 3
  • Xenobiotic Monooxygenase 3
  • P1-450 3
  • P450-C 3
  • P450DX 3
  • AhRR 3
  • CP11 3
  • CYP1 3
  • AHH 3

External Ids for CYP1A1 Gene

Previous HGNC Symbols for CYP1A1 Gene

  • CYP1

Previous GeneCards Identifiers for CYP1A1 Gene

  • GC15M068848
  • GC15M068126
  • GC15M072587
  • GC15M072727
  • GC15M072798
  • GC15M075011
  • GC15M051809

Summaries for CYP1A1 Gene

Entrez Gene Summary for CYP1A1 Gene

  • This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2016]

GeneCards Summary for CYP1A1 Gene

CYP1A1 (Cytochrome P450 Family 1 Subfamily A Member 1) is a Protein Coding gene. Diseases associated with CYP1A1 include Lung Squamous Cell Carcinoma and Pyridoxine Deficiency. Among its related pathways are Phenytoin Pathway, Pharmacokinetics and Estrone metabolism. GO annotations related to this gene include enzyme binding and iron ion binding. An important paralog of this gene is CYP17A1.

UniProtKB/Swiss-Prot for CYP1A1 Gene

  • Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Gene Wiki entry for CYP1A1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYP1A1 Gene

Genomics for CYP1A1 Gene

Products:

  1. Regulatory Element

Regulatory Elements for CYP1A1 Gene

Enhancers for CYP1A1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CYP1A1 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the CYP1A1 gene promoter:

Genomic Location for CYP1A1 Gene

Chromosome:
15
Start:
74,719,542 bp from pter
End:
74,725,610 bp from pter
Size:
6,069 bases
Orientation:
Minus strand

Genomic View for CYP1A1 Gene

Genes around CYP1A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CYP1A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CYP1A1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CYP1A1 Gene

Proteins for CYP1A1 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for CYP1A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P04798-CP1A1_HUMAN
    Recommended name:
    Cytochrome P450 1A1
    Protein Accession:
    P04798
    Secondary Accessions:
    • A4F3V9
    • A4F3W0
    • Q53G18

    Protein attributes for CYP1A1 Gene

    Size:
    512 amino acids
    Molecular mass:
    58165 Da
    Cofactor:
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CYP1A1 Gene

    Alternative splice isoforms for CYP1A1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CYP1A1 Gene

Proteomics data for CYP1A1 Gene at MOPED

Protein Expression for CYP1A1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for CYP1A1 Gene

P04798:

Post-translational modifications for CYP1A1 Gene

  • Glycosylation at Ser 67
  • Modification sites at PhosphoSitePlus

Other Protein References for CYP1A1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for CYP1A1 Gene

Gene Families for CYP1A1 Gene

HGNC:
IUPHAR :

Protein Domains for CYP1A1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CYP1A1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P04798

UniProtKB/Swiss-Prot:

CP1A1_HUMAN :
  • Belongs to the cytochrome P450 family.
Family:
  • Belongs to the cytochrome P450 family.
genes like me logo Genes that share domains with CYP1A1: view

Function for CYP1A1 Gene

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  2. CRISPR
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  4. Inhibitory RNA
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  7. Flow Cytometry

Molecular function for CYP1A1 Gene

GENATLAS Biochemistry:
cytochrome p450,family I (polycytic aromatic compound-inducible),member A1 (see CYP1@),associated with susceptibility to lung squamous cell carcinoma and to childhood acute lymphoblastic leukemia (in association with deletion of GSTM1)
UniProtKB/Swiss-Prot CatalyticActivity:
RH + [reduced NADPH--hemoprotein reductase] + O(2) = ROH + [oxidized NADPH--hemoprotein reductase] + H(2)O.
UniProtKB/Swiss-Prot Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
UniProtKB/Swiss-Prot Induction:
By 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).

Enzyme Numbers (IUBMB) for CYP1A1 Gene

Gene Ontology (GO) - Molecular Function for CYP1A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004497 monooxygenase activity IBA,TAS --
GO:0016679 oxidoreductase activity, acting on diphenols and related substances as donors IEA --
genes like me logo Genes that share ontologies with CYP1A1: view

Phenotypes for CYP1A1 Gene

MGI mutant phenotypes for CYP1A1:
inferred from 6 alleles
GenomeRNAi human phenotypes for CYP1A1:
genes like me logo Genes that share phenotypes with CYP1A1: view

Human Phenotype Ontology for CYP1A1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for CYP1A1 Gene

MGI Knock Outs for CYP1A1:

Animal Model Products

miRNA for CYP1A1 Gene

miRTarBase miRNAs that target CYP1A1

Inhibitory RNA Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for CYP1A1 Gene

Localization for CYP1A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYP1A1 Gene

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CYP1A1 Gene COMPARTMENTS Subcellular localization image for CYP1A1 gene
Compartment Confidence
endoplasmic reticulum 5
mitochondrion 3
nucleus 3
cytosol 2
extracellular 2
peroxisome 2
plasma membrane 2
cytoskeleton 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for CYP1A1 Gene

Pathways & Interactions for CYP1A1 Gene

genes like me logo Genes that share pathways with CYP1A1: view

Gene Ontology (GO) - Biological Process for CYP1A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001666 response to hypoxia IEA --
GO:0001889 liver development IEA --
GO:0006778 porphyrin-containing compound metabolic process IEA --
GO:0006805 xenobiotic metabolic process TAS --
GO:0008283 cell proliferation IEA --
genes like me logo Genes that share ontologies with CYP1A1: view

No data available for SIGNOR curated interactions for CYP1A1 Gene

Drugs & Compounds for CYP1A1 Gene

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  1. Drug

(172) Drugs for CYP1A1 Gene - From: DrugBank, PharmGKB, FDA Approved Drugs, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Chlorzoxazone Approved Pharma Agonist, Activator, Enzyme, substrate 6
Clofibrate Approved Pharma Agonist, Enzyme, inducer 2
Daunorubicin Approved Pharma Enzyme, substrate 254
Dexamethasone Approved, Investigational Pharma Agonist, Enzyme, inhibitor, inducer 1950
Dronabinol Approved, Illicit Pharma Enzyme, substrate 131

(105) Additional Compounds for CYP1A1 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
11,12,15-THETA
  • 11,12,15-TriHETRE
  • 11,12,15-Trihydroxyicosatrienoate
  • 11,12,15-Trihydroxyicosatrienoic acid
  • 11,12,15S-Trihydroxy-5Z,8Z,13E-eicosatrienoate
  • 11,12,15S-Trihydroxy-5Z,8Z,13E-eicosatrienoic acid
11,12-Epoxyeicosatrienoic acid
  • (5Z,8Z,14Z)-11,12-Epoxyeicosa-5,8,14-trienoate
  • (5Z,8Z,14Z)-11,12-Epoxyeicosa-5,8,14-trienoic acid
  • (5Z,8Z,14Z)-11,12-Epoxyicosa-5,8,14-trienoate
  • (5Z,8Z,14Z)-11,12-Epoxyicosa-5,8,14-trienoic acid
  • 10-(3-(2-Octenyl)oxiranyl)-5,8-Decadienoate
 81276-02-0
11,14,15-THETA
  • (5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoate
  • (5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoic acid
  • (5Z,8Z,12E)-11,14,15-Trihydroxyicosa-5,8,12-trienoate
  • (5Z,8Z,12E)-11,14,15-Trihydroxyicosa-5,8,12-trienoic acid
  • 11,14,15-Trihydroxy-5Z,8Z,12E-eicosatrienoate
11H-14,15-EETA
  • (5Z,8Z,12E)-14,15-Epoxy-11-hydroxyeicosa-5,8,12-trienoate
  • (5Z,8Z,12E)-14,15-Epoxy-11-hydroxyeicosa-5,8,12-trienoic acid
  • (5Z,8Z,12E)-14,15-Epoxy-11-hydroxyicosa-5,8,12-trienoate
  • (5Z,8Z,12E)-14,15-Epoxy-11-hydroxyicosa-5,8,12-trienoic acid
  • 11-Hydroxy-14,15-EETA
 219535-29-2
12,13-EpOME
  • (+/-)-12(13)-epoxy-9Z-octadecenoate
  • (+/-)-12(13)-epoxy-9Z-octadecenoic acid
  • (9Z)-11-(3-pentyloxiran-2-yl)undec-9-enoate
  • (9Z)-11-(3-pentyloxiran-2-yl)undec-9-enoic acid
  • (9Z)-12,13-epoxyoctadecenoate
genes like me logo Genes that share compounds with CYP1A1: view

Transcripts for CYP1A1 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
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mRNA/cDNA for CYP1A1 Gene

(4) REFSEQ mRNAs :
(15) Additional mRNA sequences :
(52) Selected AceView cDNA sequences:
(10) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CYP1A1 Gene

Cytochrome P450, family 1, subfamily A, polypeptide 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CYP1A1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
SP1:
SP2:

Relevant External Links for CYP1A1 Gene

GeneLoc Exon Structure for
CYP1A1
ECgene alternative splicing isoforms for
CYP1A1

Expression for CYP1A1 Gene

Products:

  1. Primer

mRNA expression in normal human tissues for CYP1A1 Gene

mRNA expression in normal human tissues for CYP1A1 Gene
mRNA expression by BioGPS for CYP1A1 GenemRNA expression by GTEx for CYP1A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CYP1A1 Gene

This gene is overexpressed in Liver (x8.2), Lung (x5.5), Adipose - Subcutaneous (x5.0), and Skin - Sun Exposed (Lower leg) (x4.0).

Protein differential expression in normal tissues from HIPED for CYP1A1 Gene

This gene is overexpressed in Gallbladder (22.6), Liver (18.4), Plasma (12.0), Pancreatic juice (10.0), and Islet of Langerhans (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CYP1A1 Gene



SOURCE GeneReport for Unigene cluster for CYP1A1 Gene Hs.72912

mRNA Expression by UniProt/SwissProt for CYP1A1 Gene

P04798-CP1A1_HUMAN
Tissue specificity: Lung, lymphocytes and placenta.
genes like me logo Genes that share expression patterns with CYP1A1: view

Protein tissue co-expression partners for CYP1A1 Gene

Primer Products

Orthologs for CYP1A1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CYP1A1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
 Mammalia CYP1A1 35
  • 85.42 (n)
  • 81.18 (a)
CYP1A1 36
  • 80 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia CYP1A1 35
  • 84.65 (n)
  • 82.09 (a)
CYP1A1 36
  • 80 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Cyp1a1 35
  • 82.61 (n)
  • 80.39 (a)
Cyp1a1 16
Cyp1a1 36
  • 78 (a)
 OneToOne
chimpanzee
(Pan troglodytes)
 Mammalia LOC453744 35
  • 99.67 (n)
  • 99.8 (a)
CYP1A1 36
  • 100 (a)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Cyp1a1 35
  • 82.42 (n)
  • 79.61 (a)
oppossum
(Monodelphis domestica)
 Mammalia -- 36
  • 72 (a)
 ManyToMany
-- 36
  • 59 (a)
 ManyToMany
platypus
(Ornithorhynchus anatinus)
 Mammalia -- 36
  • 70 (a)
 OneToMany
chicken
(Gallus gallus)
 Aves CYP1A1 35
  • 67.06 (n)
  • 62.4 (a)
CYP1A1 36
  • 60 (a)
 ManyToMany
CYP1A4 36
  • 58 (a)
 ManyToMany
lizard
(Anolis carolinensis)
 Reptilia -- 36
  • 55 (a)
 ManyToMany
-- 36
  • 58 (a)
 ManyToMany
-- 36
  • 60 (a)
 ManyToMany
tropical clawed frog
(Silurana tropicalis)
 Amphibia cyp1a1 35
  • 65.14 (n)
  • 63.22 (a)
Str.2144 35
zebrafish
(Danio rerio)
 Actinopterygii cyp1a 35
  • 60.88 (n)
  • 57.88 (a)
cyp1a1 35
cyp1a 36
  • 55 (a)
 OneToMany
fruit fly
(Drosophila melanogaster)
 Insecta Cyp18a1 37
  • 32 (a)
Cyp307a1 37
  • 28 (a)
spo 36
  • 24 (a)
 ManyToMany
spok 36
  • 22 (a)
 ManyToMany
thale cress
(Arabidopsis thaliana)
 eudicotyledons CYP93D1 35
  • 40.54 (n)
  • 28.05 (a)
rice
(Oryza sativa)
 Liliopsida Os06g0613600 35
  • 45.38 (n)
  • 31.3 (a)
sea squirt
(Ciona savignyi)
 Ascidiacea -- 36
  • 31 (a)
 ManyToMany
-- 36
  • 21 (a)
 ManyToMany
Species with no ortholog for CYP1A1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CYP1A1 Gene

ENSEMBL:
Gene Tree for CYP1A1 (if available)
TreeFam:
Gene Tree for CYP1A1 (if available)

Paralogs for CYP1A1 Gene

Paralogs for CYP1A1 Gene

(30) SIMAP similar genes for CYP1A1 Gene using alignment to 8 proteins:

Pseudogenes.org Pseudogenes for CYP1A1 Gene

genes like me logo Genes that share paralogs with CYP1A1: view

Variants for CYP1A1 Gene

Sequence variations from dbSNP and Humsavar for CYP1A1 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1048943 - 74,720,644(-) AGACC(A/C/G/T)TTGCC reference, missense
rs1799814 - 74,720,646(-) TGAGA(A/C/T)CATTG reference, missense
rs34260157 - 74,721,708(-) ACATC(C/G/T)GGGAC reference, missense
rs56313657 - 74,721,463(+) AAATA(A/C/T)ATGAG reference, missense
VAR_016938 -

Structural Variations from Database of Genomic Variants (DGV) for CYP1A1 Gene

Variant ID Type Subtype PubMed ID
nsv904379 CNV Loss 21882294
nsv904380 CNV Loss 21882294
nsv817698 CNV Gain 17921354
nsv833055 CNV Loss 17160897

Variation tolerance for CYP1A1 Gene

Residual Variation Intolerance Score: 96.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.23; 84.97% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CYP1A1 Gene

Human Gene Mutation Database (HGMD)
CYP1A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CYP1A1 Gene

Disorders for CYP1A1 Gene

MalaCards: The human disease database

(34) MalaCards diseases for CYP1A1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
lung squamous cell carcinoma
  • epidermoid cell carcinoma of the lung
pyridoxine deficiency
  • vitamin b6 deficiency
ehrlich tumor carcinoma
  • ehrlich's tumor
oral cavity cancer
  • malignant neoplasm of anterior portion of floor of mouth
oral cancer
  • malignant neoplasm of mouth
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CYP1A1

Genetic Association Database (GAD)
CYP1A1
Human Genome Epidemiology (HuGE) Navigator
CYP1A1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CYP1A1
genes like me logo Genes that share disorders with CYP1A1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CYP1A1 Gene

Publications for CYP1A1 Gene

  1. Variation in induced CYP1A1 levels: relationship to CYP1A1, Ah receptor and GSTM1 polymorphisms. (PMID: 10739168) Smart J. … Daly A.K. (Pharmacogenetics 2000) 3 4 23 67
  2. Inhibition of procarcinogen-bioactivating human CYP1A1, CYP1A2 and CYP1B1 enzymes by melatonin. (PMID: 19919601) Chang T.K. … Yeung E.Y. (J. Pineal Res. 2010) 23 25 26
  3. Chlorzoxazone metabolism by porcine cytochrome P450 enzymes and the effect of cytochrome b5. (PMID: 20164110) Wiercinska P. … Squires E.J. (Drug Metab. Dispos. 2010) 23 25 26
  4. Role of adrenoceptor-linked signaling pathways in the regulation of CYP1A1 gene expression. (PMID: 15627480) Konstandi M. … Lang M.A. (Biochem. Pharmacol. 2005) 23 25 26
  5. Induction of CYP1A1 by GABA receptor ligands. (PMID: 8954111) Sadar M.D. … Andersson T.B. (Biochem. Biophys. Res. Commun. 1996) 23 25 26

Products for CYP1A1 Gene

Sources for CYP1A1 Gene

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