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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CYP1A1 Gene

protein-coding   GIFtS: 73
GCID: GC15M075011

Cytochrome P450, Family 1, Subfamily A, Polypeptide 1

(Previous names: cytochrome P450, subfamily I (aromatic compound-inducible),...)
(Previous symbol: CYP1)
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Aliases
for CYP1A1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section
Aliases
Cytochrome P450, Family 1, Subfamily A, Polypeptide 11 2     CP112
CYP11 2 5     P1-4502
Cytochrome P450, Subfamily I (Aromatic Compound-Inducible), Polypeptide 11 2     P450-C2
Cytochrome P450 Form 62 3     P450DX2
Cytochrome P450-C2 3     Aryl Hydrocarbon Hydroxylase2
Cytochrome P450-P12 3     Cytochrome P1-450, Dioxin-Inducible2
CYPIA12 3     Cytochrome P450 1A12
EC 1.14.14.13 8     Flavoprotein-Linked Monooxygenase2
AHH2     Xenobiotic Monooxygenase2
AHRR2     

External Ids:    HGNC: 25951   Entrez Gene: 15432   Ensembl: ENSG000001404657   OMIM: 1083305   UniProtKB: P047983   

Export aliases for CYP1A1 gene to outside databases

Previous GC identifers: GC15M068848 GC15M068126 GC15M072587 GC15M072727 GC15M072798 GC15M051809


Summaries
for CYP1A1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CYP1A1 Gene:
This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins
are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol,
steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by
some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous
substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has
been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from
CYP1A1 on chromosome 15. (provided by RefSeq, Jul 2008)

GeneCards Summary for CYP1A1 Gene: 
CYP1A1 (cytochrome P450, family 1, subfamily A, polypeptide 1) is a protein-coding gene. Diseases associated with CYP1A1 include basal cell carcinoma, multiple, and oral cancer, and among its related super-pathways are Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) and Cytochrome P450 - arranged by substrate type. GO annotations related to this gene include iron ion binding and enzyme binding. An important paralog of this gene is CYP1A2.

UniProtKB/Swiss-Prot: CP1A1_HUMAN, P04798
Function: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is
involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated
compounds, including steroids, fatty acids, and xenobiotics

Gene Wiki entry for CYP1A1 (Cytochrome P450, family 1, member A1) Gene


Genomic Views
for CYP1A1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NT_010194.17  NC_018926.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CYP1A1 gene promoter:
         GR   C/EBPbeta   p53   SREBP-1c   Bach2   SREBP-1b   HNF-4alpha1   MZF-1   SREBP-1a   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): CYP1A1 promoter sequence
   Search SABiosciences Chromatin IP Primers for CYP1A1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CYP1A1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q24.1   Ensembl cytogenetic band:  15q24.1   HGNC cytogenetic band: 15q24.1

CYP1A1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CYP1A1 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M075011:  view genomic region     (about GC identifiers)

Start:
 75,011,883 bp from pter      End:
 75,017,951 bp from pter
Size:
 6,069 bases      Orientation:
 minus strand

Proteins
for CYP1A1 gene

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section
UniProtKB/Swiss-Prot: CP1A1_HUMAN, P04798 (See protein sequence)
Recommended Name: Cytochrome P450 1A1  
Size: 512 amino acids; 58165 Da
Cofactor: Heme group
Subcellular location: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral
membrane protein
1 PDB 3D structure from and Proteopedia for CYP1A1:
4I8V (3D)    
Secondary accessions: Q53G18

Explore the universe of human proteins at neXtProt for CYP1A1: NX_P04798

Explore proteomics data for CYP1A1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P04798

    • 4/25 DME Specific Peptides for CYP1A1 (P04798) (see all 25)
     FSIASDP  PILRYLP  NQWQINH  ELDTVIG 

    CYP1A1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CYP1A1 Protein Expression
    REFSEQ proteins: NP_000490.1  
    ENSEMBL proteins: 
     ENSP00000369050   ENSP00000456585   ENSP00000378489   ENSP00000455340   ENSP00000457668  
     ENSP00000455051   ENSP00000455846   ENSP00000378488  
    Reactome Protein details: P04798
    Human Recombinant Protein Products for CYP1A1: 
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    Novus Biologicals CYP1A1 Protein
    Novus Biologicals CYP1A1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CYP1A1 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005739mitochondrion IEA--
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0043231intracellular membrane-bounded organelle ----

    CYP1A1 for ontologies           About GeneDecksing



    CYP1A1 Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for CYP1A1 

    Assay Products for CYP1A1: 
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CYP1A1 
    Cloud-Clone Corp. CLIAs for CYP1A1

    Protein Domains /
    Families
    for CYP1A1 gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    		 HGNC Gene Families: 
    CYP: Cytochrome P450s

    IUPHAR Guide to PHARMACOLOGY protein family classification: CYP1A1 
    CYP1 family

    4 InterPro protein domains:
     IPR001128 Cyt_P450
     IPR017972 Cyt_P450_CS
     IPR002401 Cyt_P450_E_grp-I
     IPR008066 Cyt_P450_E_grp-I_CYP1

    Graphical View of Domain Structure for InterPro Entry P04798

    ProtoNet protein and cluster: P04798

    2 Blocks protein domains:
    IPB002401 E-class P450 group I signature
    IPB008066 CYP1A P450 family signature


    UniProtKB/Swiss-Prot: CP1A1_HUMAN, P04798
    Similarity: Belongs to the cytochrome P450 family


    CYP1A1 for domains           About GeneDecksing


    Function
    for CYP1A1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CP1A1_HUMAN, P04798
    Function: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is
    involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated
    compounds, including steroids, fatty acids, and xenobiotics
    Catalytic activity: RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O
    Induction: By 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)

         Genatlas biochemistry entry for CYP1A1:
    cytochrome p450,family I (polycytic aromatic compound-inducible),member A1 (see CYP1@),associated with
    susceptibility to lung squamous cell carcinoma and to childhood acute lymphoblastic leukemia (in association with
    deletion of GSTM1)

         Enzyme Number (IUBMB): EC 1.14.14.11 2

         Gene Ontology (GO): 5/17 molecular function terms (GO ID links to tree view) (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004497monooxygenase activity ----
    GO:0005506iron ion binding IEA--
    GO:0005515protein binding ----
    GO:0008395steroid hydroxylase activity IEA--
         
    CYP1A1 for ontologies           About GeneDecksing


    Phenotypes:
         9 MGI mutant phenotypes (inferred from 7 alleles) (MGI details for Cyp1a1):
     cardiovascular system  growth/size  hematopoietic system  homeostasis/metabolism  immune system 
     liver/biliary system  mortality/aging  no phenotypic analysis  normal 

    CYP1A1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for CYP1A1: Cyp1a1tm1.1Dwn Cyp1a2/Cyp1a1Cyp1a2/tm2Dwn Cyp1a2/Cyp1a1Cyp1a2/tm1.1Bra

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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CYP1A1 
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    miRNA
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    Inhib. RNA
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of CYP1A1

    Clone
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    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYP1A1


    Pathways & Interactions
    for CYP1A1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CYP1A1 About   (see all 21)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)
    		Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)0.55
    		Benzo[a]pyrene metabolism0.43
    		Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)0.55
    		Amodiaquine Pathway, Pharmacokinetics0.38
    		Warfarin Pathway, Pharmacokinetics0.45
    2Cytochrome P450 - arranged by substrate type
    		Cytochrome P450 - arranged by substrate type0.75
    		Phase 1 - Functionalization of compounds0.74
    		cytochrome P4500.75
    3Acetaminophen metabolism
    		Acetaminophen metabolism0.43
    		2-Naphthylamine and 2-Nitronaphtalene metabolism0.32
    		Acetaminophen Pathway, Pharmacokinetics0.43
    4Metabolism
    		Metabolism0.40
    		Metabolism of lipids and lipoproteins0.34
    		Metabolic pathways0.40
    5Tamoxifen metabolism
    		Tamoxifen metabolism0.68
    		Estradiol metabolism0.52

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/7 EMD Millipore Pathways for CYP1A1 (see all 7)
        Androstenedione and testosterone biosynthesis and metabolism p.1
    Estradiol metabolism
    2-Naphthylamine and 2-Nitronaphtalene metabolism
    Retinol metabolism
    Naphthalene metabolism


    5/7 GeneGo (Thomson Reuters) Pathways for CYP1A1 (see all 7)
        Estradiol metabolism
    Retinol metabolism
    Naphthalene metabolism
    2-Naphthylamine and 2-Nitronaphtalene metabolism
    Benzo[a]pyrene metabolism

    5/9 BioSystems Pathways for CYP1A1 (see all 9)
        cytochrome P450
    Oxidative Stress
    Tamoxifen metabolism
    Estrogen metabolism
    Benzo(a)pyrene metabolism


    5/12        Reactome Pathways for CYP1A1 (see all 12)
        Cytochrome P450 - arranged by substrate type
    Xenobiotics
    Metabolism
    Arachidonic acid metabolism
    Fatty acid, triacylglycerol, and ketone body metabolism

    5/6 PharmGKB Pathways for CYP1A1 (see all 6)
        Acetaminophen Pathway, Pharmacokinetics
    Amodiaquine Pathway, Pharmacokinetics
    Erlotinib Pathway, Pharmacokinetics
    Estrogen Metabolism Pathway
    Gefitinib Pathway, Pharmacokinetics

    5/7         Kegg Pathways  (Kegg details for CYP1A1) (see all 7):
        Steroid hormone biosynthesis
    Tryptophan metabolism
    Retinol metabolism
    Metabolism of xenobiotics by cytochrome P450
    Metabolic pathways


    CYP1A1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CYP1A1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/90 Interacting proteins for CYP1A1 (P047983 ENSP000003690504) via UniProtKB, MINT, STRING, and/or I2D (see all 90)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CYB5AP001673, ENSP000003416254I2D: score=1 STRING: ENSP00000341625
    HSP90AA1P079003I2D: score=1 
    HSPA4P349323I2D: score=1 
    AKR1C1ENSP000003702544STRING: ENSP00000370254
    AKR1C3ENSP000003699274STRING: ENSP00000369927
    About this table

    Gene Ontology (GO): 5/48 biological process terms (GO ID links to tree view) (see all 48):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001666response to hypoxia IEA--
    GO:0001889liver development ----
    GO:0006778porphyrin-containing compound metabolic process IEA--
    GO:0006805xenobiotic metabolic process TAS--
    GO:0006950response to stress ----

    CYP1A1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CYP1A1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CYP1A1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CYP1A1 (CP1A1)

    10/54 HMDB Compounds for CYP1A1 (see all 54)    About this table
    CompoundSynonyms CAS #PubMed Ids
    Melatonin5-Methoxy-N-acetyltryptamine (see all 23)73-31-419919601
    10-HETE10-hydroxyeicosa-all-cis-5,8,11,14-tetraenoate (see all 2)167697-52-1--
    11,12,15-THETA11,12,15-Trihydroxyicosatrienoic acid (see all 5)----
    11,12-Epoxyeicosatrienoic acid10-(3-(2-octenyl)oxiranyl)-5,8-Decadienoic acid (see all 15)81276-02-0--
    11,14,15-THETA(5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoic acid (see all 8)----
    11H-14,15-EETA14,15-Ep-11-HETrE (see all 11)219535-29-2--
    11beta-Hydroxytestosterone11beta,17beta-dihydroxyandrost-4-en-3-one 1816-85-9--
    12,13-EpOMEVernolic acid (see all 12)----
    13-HETE13-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoate (see all 2)151910-72-4--
    14,15-Epoxy-5,8,11-eicosatrienoic acid(5Z,8Z,11Z)-14,15-Epoxyicosa-5.8.11-trienoic acid (see all 11)81276-03-1--

    10/90 DrugBank Compounds for CYP1A1 (see all 90)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    ErlotinibCP358774 (see all 2)183321-74-6enzymesubstrate17575239 16166415 19733976
    MelatoninMEL (see all 4)73-31-4enzymesubstrate inhibitor19919601 15616152 19934256
    TamoxifenICI-46474 (see all 3)10540-29-1enzymesubstrate12124303 19934256 19515014
    AmiodaroneAmiodarona [INN-Spanish] (see all 5)1951-25-3enzymesubstrate18445370 19934256
    AmlodipineAmlodipine Benzenesulfonate (see all 6)88150-42-9enzymeinhibitor10805063 19934256
    Benzyl alcohol(Hydroxymethyl)benzene (see all 10)100-51-6enzyme--9065730 9726784
    ChlorzoxazoneChloroxazone (see all 3)95-25-0enzymesubstrate15231049 20164110
    Cinnarizine-- 298-57-7enzymesubstrate19934256 19515014
    Dasatinib-- 302962-49-8enzymesubstrate18556438 19733976
    Ellagic Acid-- 476-66-4enzymeinhibitor inducer8024593 19469472

    10/140 Novoseek inferred chemical compound relationships for CYP1A1 gene (see all 140)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tcdd 94 698 8396892 (9), 15630080 (7), 11728381 (6), 9931287 (6) (see all 99)
    ethoxyresorufin 91.1 84 17959138 (4), 8093105 (3), 11599655 (2), 8396892 (1) (see all 67)
    benzo(a)pyrene 89.7 376 18372000 (6), 19330882 (6), 16280210 (6), 10503953 (6) (see all 99)
    alpha-naphthoflavone 88.1 64 1329656 (4), 12628305 (2), 2115161 (2), 1315629 (1) (see all 38)
    3-methylcholanthrene 86.4 193 12941938 (7), 16137816 (4), 17276403 (3), 9465551 (3) (see all 64)
    hydrocarbons 85.2 131 8954573 (2), 17630984 (2), 19362136 (2), 8353849 (2) (see all 99)
    mspi 84.8 71 1284589 (4), 8706015 (3), 8877059 (3), 8983277 (2) (see all 51)
    beta-naphthoflavone 82.9 79 11076701 (3), 12147246 (3), 18502397 (3), 19470599 (3) (see all 36)
    4-methoxyestradiol 79.6 1 10403516 (1)
    benz(a)anthracene 78.8 30 1700499 (4), 8920757 (2), 1358564 (2), 1654865 (2) (see all 14)

    Search CenterWatch for drugs/clinical trials and news about CYP1A1 / CP1A1

    Transcripts
    for CYP1A1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CYP1A1 gene: 
    NM_000499.3  

    Unigene Cluster for CYP1A1:

    Cytochrome P450, family 1, subfamily A, polypeptide 1
    Hs.72912  [show with all ESTs]
    Unigene Representative Sequence: NM_000499
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000379727(uc002ayq.4 uc010bjy.3) ENST00000567032 ENST00000395049
    ENST00000562201 ENST00000564596(uc010bjz.1) ENST00000569630 ENST00000566503
    ENST00000395048(uc002ayp.4 uc010bju.3 uc010bjv.3 uc010bjw.3 uc010bjx.3)

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    AK223108.1 AK223113.1 AK310810.1 AK313880.1 AM233517.1 AM233518.1 AM233519.1 AM233520.1 
    AM236046.1 AM236047.1 AY310359.1 AY871801.1 BC023019.1 K03191.1 M12079.1 

    2 DOTS entries:

    DT.310017  DT.100744671 

    24/52 AceView cDNA sequences (see all 52):

    BQ878741 NM_000499 BQ005861 AL600770 CA423835 AL600919 AW949660 AL600881 
    BC023019 AI417887 AV656441 BU620769 AW451941 BU182605 K03191 CB265483 
    CA439920 M12079 BU941041 AI745534 AL598658 BP353358 BF437793 CA426401 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for CYP1A1    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
    SP1:                                                
    SP2:                                                


    ECgene alternative splicing isoforms for CYP1A1

    Expression
    for CYP1A1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CYP1A1 expression in normal human tissues (normalized intensities)      CYP1A1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTGCATAAG
    CYP1A1 Expression
    About this image


    CYP1A1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Endothelium (Cardiovascular System)    fully expand to see all 3 entries
             PureStem ES-335, Meso-latp Progenitor
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             PureStem endothelial progenitor 30-MV2-12
     
     Lung (Respiratory System)
             Basal Cells Respiratory Bronchioles
     
     Liver (Hepatobiliary System)
             Perivenous Hepatocytes Liver Lobule
     
     Intestine (Gastrointestinal Tract)
             ileum   

    See CYP1A1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CYP1A1

    SOURCE GeneReport for Unigene cluster: Hs.72912

    UniProtKB/Swiss-Prot: CP1A1_HUMAN, P04798
    Tissue specificity: Lung, lymphocytes and placenta

        SABiosciences Expression via Pathway-Focused PCR Arrays including CYP1A1 (see all 6): 
              Estrogen Receptor Signaling in human mouse rat
              Cancer Drug Resistance in human mouse rat
              Drug Metabolism: Phase I Enzymes in human mouse rat
              Cellular Stress Responses in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

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    In Situ
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    Orthologs
    for CYP1A1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CYP1A1 gene from 8/16 species (see all 16)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Cyp1a11 , 5 cytochrome P450, family 1, subfamily a, polypeptide more1, 5 82.71(n)1
    80.55(a)1    		   9 (31.34 cM)5
    130761  NM_001136059.21  NP_001129531.11 
     576976135 
    chicken
    (Gallus gallus)    		 Aves CYP1A11 cytochrome P450, family 1, subfamily A, polypeptide more 67.06(n)
    62.4(a)    		   396051  NM_205146.1  NP_990477.1 
    lizard
    (Anolis carolinensis)    		 Reptilia --
    --
    (see all 3)    		 Uncharacterized protein
    (see all 3)    		 60(a)
    58(a)
    (see all 3)    		 many ↔ many
    many ↔ many
    (see all 3)    		 GL343721.1(50982-63103)
    GL343721.1(108802-116982)
    African clawed frog
    (Xenopus laevis)    		 Amphibia AB022087.12   -- 71.3(n)    AB022087.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii cyp1a12 cytochrome P450, subfamily I, polypeptide 1 74.16(n)   140634  AB078927.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Cyp18a13 steroid biosynthesis cytochrome P450 32(a)
    (best of 2)    		   17D1   --
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons CYP93D11 cytochrome P450, family 93, subfamily D, polypeptide more 41.25(n)
    28.29(a)    		   830580  NM_120772.1  NP_196307.1 
    rice
    (Oryza sativa)    		 Liliopsida Os06g06136001 hypothetical protein 46.09(n)
    32.35(a)    		   4341526  NM_001064607.1  NP_001058072.1 


    ENSEMBL Gene Tree for CYP1A1 (if available)
    TreeFam Gene Tree for CYP1A1 (if available)

    Paralogs
    for CYP1A1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CYP1A1 gene
    CYP1A22  CYP1B12  CYP2D7P12  CYP17A12  CYP21A22  
    18/30 SIMAP similar genes for CYP1A1 using alignment to 10 protein entries:     CP1A1_HUMAN (see all proteins) (see all similar genes):
    CYP1A2    CYP1B1    CYP2U1    CYP2S1    CYP4V2    DKFZp686I24235
    CYP2D6    CYP21A2    CYP2A7    CYP2A13    CYP2A6    CYP2C9
    CYP2C8    CYP2R1    CYP2B7    CYP2F1    CYP2J2    CYP2A6V2

    CYP1A1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CYP1A1
    PGOHUM00000236640


    Genomic Variants
    for CYP1A1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/294 SNPs in CYP1A1 are shown (see all 294)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 15 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    VAR_0169394
    		----see VAR_0169392 R C mis40--------
    VAR_0169384
    		----see VAR_0169382 I N mis40--------
    rs1494232661,2
    		--55062351(+) AGGGCA/GTAAGT 1 -- ds50010--------
    rs456271341,2
    		C,F--55062527(-) CGCAGG/CCACAC 1 -- ds50015Minor allele frequency- C:0.01NS 176
    rs798120151,2
    		F--55062576(+) GAGCCT/CGGAGG 1 -- ds50011Minor allele frequency- C:0.39PA 802
    rs46469031,2
    		C,F,A,H--55062577(-) CCTCCA/C/TGGGCT 1 -- ds500117NA MN NS WA CSA EA 934
    rs1397748601,2
    		--55062715(+) TGCTAC/TCTCCT 1 -- ds50010--------
    rs1889132831,2
    		C--55062779(+) TTAGAC/GGAGTG 1 -- ds50010--------
    rs1817168151,2
    		--55062780(+) TAGACA/GAGTGA 1 -- ds50010--------
    rs24723071,2
    		C,H--55062791(+) TGAATC/TATTTA 1 -- ds500111Minor allele frequency- T:0.00NS EA NA MN 812

    HapMap Linkage Disequilibrium report for CYP1A1 (75011883 - 75017951 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for CYP1A1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv904380CNV Loss21882294
    nsv904379CNV Loss21882294
    nsv833055CNV Loss17160897
    nsv817698CNV Gain17921354


    Human Gene Mutation Database (HGMD): CYP1A1

    Locus Specific Mutation Databases (LSDB): CYP1A1
    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for CYP1A1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    		 OMIM gene information: 108330    OMIM disorders: --

    20/169 diseases for CYP1A1 (see all 169):    About MalaCards
    basal cell carcinoma, multiple    oral cancer    leukoplakia    basal cell carcinoma
    cytochrome p450    lung cancer    oral cavity cancer    cardia cancer
    hidradenitis suppurativa    malignant hypertension    hidradenitis    breast disease
    endometriosis    hepatocellular adenoma    placental choriocarcinoma    laryngitis
    porphyria cutanea tarda    familial prostate cancer    intrahepatic cholestasis of pregnancy    skin cancer

    4 diseases from the University of Copenhagen DISEASES database for CYP1A1:
    Lung cancer     Hepatocellular carcinoma     Breast cancer     Carcinoma

    CYP1A1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/93 Novoseek inferred disease relationships for CYP1A1 gene (see all 93)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ahh inducibility 87.7 42 8126925 (5), 8609043 (5), 9465551 (5), 9731718 (4) (see all 10)
    cancer lung 68.2 293 9894148 (6), 11778487 (6), 16228113 (6), 10491856 (5) (see all 99)
    genetic susceptibility 61.7 23 18304461 (2), 10698723 (1), 19472123 (1), 20054510 (1) (see all 18)
    chemical carcinogenesis 58 6 12628305 (1), 19573549 (1), 12520071 (1), 11370663 (1) (see all 6)
    cancer 57.9 119 8552885 (3), 15355884 (3), 15805301 (2), 16402077 (2) (see all 91)
    breast cancer 57.1 155 9485019 (6), 20088394 (5), 11408954 (5), 16807674 (4) (see all 79)
    environmental carcinogenesis 56.6 1 18463401 (1)
    oral cancer 46 35 19469619 (5), 17461521 (4), 19160101 (3), 9332761 (3) (see all 10)
    adenocarcinoma lung 43.3 14 17200336 (2), 12824892 (2), 15375499 (2), 11955671 (1) (see all 8)
    carcinoma squamous cell 43.2 41 11778487 (3), 10435155 (2), 7554077 (2), 10793329 (2) (see all 30)

    Genetic Association Database (GAD): CYP1A1
    Human Genome Epidemiology (HuGE) Navigator: CYP1A1 (699 documents)

    Export disorders for CYP1A1 gene to outside databases

    Publications
    for CYP1A1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CYP1A1 gene, integrated from 9 sources (see all 1872):
    (articles sorted by number of sources associating them with CYP1A1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Variation in induced CYP1A1 levels: relationship to CYP1A1, Ah receptor and GSTM1 polymorphisms. (PubMed id 10739168)1, 2, 9 Smart J. and Daly A.K. (2000)
    2. [Relationship between CYP1A1, GSTM1 genetic polymorphisms and susceptibility to esophageal squamous cell carcinoma] (PubMed id 11860825)1, 4, 9 Shao G....Wen B. (2000)
    3. Evidence for increased cytochrome P450 1A1 expression in blood lymphocytes of lung cancer patients. (PubMed id 19632247)1, 4, 9 Shah P.P....Parmar D. (2009)
    4. [Relationship between susceptibility and prognosis of laryngeal cancer and genetic polymorphisms in CYP1A1 and GSTM1] (PubMed id 15127559)1, 4, 9 Li L....Lu H.H. (2004)
    5. CYP1A1 gene polymorphism and risk of epithelial ovarian neoplasm. (PubMed id 12144816)1, 4, 9 Aktas D....Ayhan A. (2002)
    6. Possible risk modification by CYP1A1, GSTM1 and GSTT1 gene polymorphisms in lung cancer susceptibility in a South Indian population. (PubMed id 16228113)1, 4, 9 Sreeja L....Ankathil R. (2005)
    7. [Relationship between CYP1A1 gene polymorphisms and u rinary 1-hydroxypyrene levels in coke oven workers] (PubMed id 19538838)1, 4, 9 Nie J.S....Niu Q. (2009)
    8. CYP1A1 and GSTM1 polymorphisms and oral cancer risk: association studies via evidence-based meta-analyses. (PubMed id 19160101)1, 4, 9 Zhuo W....Chen Z. (2009)
    9. CYP1A1, SULT1A1, and SULT1E1 polymorphisms are risk factors for endometrial cancer susceptibility. (PubMed id 18318428)1, 4, 9 Hirata H....Dahiya R. (2008)
    10. Riluzole metabolism and CYP1A1/2 polymorphisms in patients with ALS. (PubMed id 17852022)1, 4, 9 Ajroud-Driss S....Lukas T.J. (2007)

    External Searches for CYP1A1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CYP1A1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1543 HGNC: 2595 AceView: CYP1A1 Ensembl:ENSG00000140465 euGenes: HUgn1543
    ECgene: CYP1A1 Kegg: 1543 H-InvDB: CYP1A1

    Other Databases showing CYP1A1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CYP1A1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CYP1A1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CYP1A1 Genetics and Cytogenetics in Oncology and Haematology
    Cytochrome P450 Allele Nomenclature Committeehttp://www.cypalleles.ki.se/cyp1a1.htm
    SHMPDhttp://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=CYP1A1
    Wikipedia http://en.wikipedia.org/wiki/CYP1A1

    Intellectual Property
    for CYP1A1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CYP1A1 gene:
    Search GeneIP for patents involving CYP1A1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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