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CYP1A1 Gene

protein-coding GIFtS: 74
GCID: GC15M075011

Cytochrome P450, Family 1, Subfamily A, Polypeptide 1

(Previous names: cytochrome P450, subfamily I (aromatic compound-inducible),...)
(Previous symbol: CYP1)

See CYP1A1-related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Cytochrome P450, Family 1, Subfamily A, Polypeptide 1¹ ²		CP11²
CYP1¹ ² ⁵		P1-450²
Cytochrome P450, Subfamily I (Aromatic Compound-Inducible), Polypeptide 1¹ ²		P450-C²
Cytochrome P450 Form 6² ³		P450DX²
Cytochrome P450-C² ³		Aryl Hydrocarbon Hydroxylase²
Cytochrome P450-P1² ³		Cytochrome P1-450, Dioxin-Inducible²
CYPIA1² ³		Cytochrome P450 1A1²
EC 1.14.14.1³ ⁸		Flavoprotein-Linked Monooxygenase²
AHH²		Xenobiotic Monooxygenase²
AHRR²

External Ids:	HGNC: 2595¹	Entrez Gene: 1543²	Ensembl: ENSG00000140465⁷	OMIM: 108330⁵	UniProtKB: P04798³

Export aliases for CYP1A1 gene to outside databases

Previous GC identifers: GC15M068848 GC15M068126 GC15M072587 GC15M072727 GC15M072798 GC15M051809

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CYP1A1 Gene:

This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins

are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol,

steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by

some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous

substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has

been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from

CYP1A1 on chromosome 15. (provided by RefSeq, Jul 2008)

GeneCards Summary for CYP1A1 Gene:

CYP1A1 (cytochrome P450, family 1, subfamily A, polypeptide 1) is a protein-coding gene. Diseases associated with CYP1A1 include oral cancer, and cardia cancer. GO annotations related to this gene include iron ion binding and enzyme binding. An important paralog of this gene is CYP1A2.

UniProtKB/Swiss-Prot: CP1A1_HUMAN, P04798

Function: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is

involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated

compounds, including steroids, fatty acids, and xenobiotics

Gene Wiki entry for CYP1A1 (Cytochrome P450, family 1, member A1) Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence at NCBI GenBank:

NC_000015.9 NT_010194.18 NC_018926.2

Regulatory elements:

Regulatory transcription factor binding sites in the CYP1A1 gene promoter:
GR C/EBPbeta p53 SREBP-1c Bach2 SREBP-1b HNF-4alpha1 MZF-1 SREBP-1a GR-alpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): CYP1A1 promoter sequence

Search Chromatin IP Primers for CYP1A1

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CYP1A1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q24.1 Ensembl cytogenetic band: 15q24.1 HGNC cytogenetic band: 15q24.1

CYP1A1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CYP1A1 gene location

GeneLoc information about chromosome 15 GeneLoc Exon Structure

GeneLoc location for GC15M075011: view genomic region (about GC identifiers)

Start:	75,011,883 bp from pter	End:	75,017,951 bp from pter
Size:	6,069 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

UniProtKB/Swiss-Prot: CP1A1_HUMAN, P04798 (See protein sequence)

Recommended Name: Cytochrome P450 1A1

Size: 512 amino acids; 58165 Da

Cofactor: Heme group

1 PDB 3D structure from and Proteopedia for CYP1A1:

4I8V (3D)

Secondary accessions: A4F3V9 A4F3W0 Q53G18

Alternative splicing: 3 isoforms: P04798-1 P04798-2 P04798-3 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CYP1A1: NX_P04798

Explore proteomics data for CYP1A1 at MOPED

Post-translational modifications:

Modification sites at neXtProt

Modification sites at PhosphoSitePlus

Selected DME Specific Peptides for CYP1A1 (P04798) (see all 25)

FSIASDP

PILRYLP

NQWQINH

ELDTVIG

See CYP1A1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_000490.1

ENSEMBL proteins:

ENSP00000369050 ENSP00000456585 ENSP00000378489 ENSP00000455340 ENSP00000457668

ENSP00000455051 ENSP00000455846 ENSP00000378488

Reactome Protein details: P04798

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	antibodies-online kits for CYP1A1 (25 products)

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
About This Section

HGNC Gene Families:

CYP: Cytochrome P450s

IUPHAR Guide to PHARMACOLOGY protein family classification: CYP1A1

CYP1 family

4 InterPro protein domains:

IPR001128 Cyt_P450

IPR017972 Cyt_P450_CS

IPR002401 Cyt_P450_E_grp-I

IPR008066 Cyt_P450_E_grp-I_CYP1

Graphical View of Domain Structure for InterPro Entry P04798

ProtoNet protein and cluster: P04798

2 Blocks protein domains:

IPB002401 E-class P450 group I signature

IPB008066 CYP1A P450 family signature

UniProtKB/Swiss-Prot: CP1A1_HUMAN, P04798

Similarity: Belongs to the cytochrome P450 family

Find genes that share domains with CYP1A1 About GenesLikeMe

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: CP1A1_HUMAN, P04798

Function: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is

involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated

compounds, including steroids, fatty acids, and xenobiotics

Catalytic activity: RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O

Induction: By 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)

Genatlas biochemistry entry for CYP1A1:

cytochrome p450,family I (polycytic aromatic compound-inducible),member A1 (see CYP1@),associated with

susceptibility to lung squamous cell carcinoma and to childhood acute lymphoblastic leukemia (in association with

deletion of GSTM1)

Enzyme Number (IUBMB): EC 1.14.14.1¹ ²

Gene Ontology (GO): Selected molecular function terms (see all 16): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003824	catalytic activity	--	--
GO:0004497	monooxygenase activity	--	--
GO:0005506	iron ion binding	IEA	--
GO:0005515	protein binding	--	--
GO:0008395	steroid hydroxylase activity	IEA	--

Find genes that share ontologies with CYP1A1 About GenesLikeMe

Phenotypes:
9 MGI mutant phenotypes (inferred from 7 alleles) (MGI details for Cyp1a1):

cardiovascular system	growth/size/body	hematopoietic system	homeostasis/metabolism	immune system
liver/biliary system	mortality/aging	no phenotypic analysis	normal

Find genes that share phenotypes with CYP1A1 About GenesLikeMe

Animal Models:
MGI mouse knock-outs for CYP1A1: Cyp1a1^tm1.1Dwn Cyp1a2/Cyp1a1^{Cyp1a2/tm2Dwn} Cyp1a2/Cyp1a1^{Cyp1a2/tm1.1Bra}

genOway: Develop your customized and physiologically relevant rodent model for CYP1A1

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Gene Editing
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYP1A1

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Subcellular locations from UniProtKB/Swiss-Prot

CP1A1_HUMAN, P04798: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral

membrane protein

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
endoplasmic reticulum	5
nucleus	3
cytosol	2
mitochondrion	2
cytoskeleton	1
extracellular	1
peroxisome	1
plasma membrane	1

About this image

Gene Ontology (GO): 4 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	--	--
GO:0005739	mitochondrion	IEA	--
GO:0005789	endoplasmic reticulum membrane	TAS	--
GO:0043231	intracellular membrane-bounded organelle	--	--

Find genes that share ontologies with CYP1A1 About GenesLikeMe

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

SuperPaths for CYP1A1 About (see all 17)

See pathways by source

Powered
by

SuperPath

Contained pathways About

Biological oxidations

Biological oxidations	0.56	Acetaminophen metabolism
metapathway biotransformation	0.42	Tamoxifen metabolism
Benzo(a)pyrene metabolism	0.00	Estradiol metabolism

Cytochrome P450 - arranged by substrate type

Cytochrome P450 - arranged by substrate type	0.75	Xenobiotics	0.00
Phase 1 - Functionalization of compounds	0.75	Fatty Acid Omega Oxidation	0.00
cytochrome P450	0.74

Chemical carcinogenesis

Metabolism of xenobiotics by cytochrome P450	0.71	Retinol metabolism	0.32
Chemical carcinogenesis	0.71	Benzo[a]pyrene metabolism	0.00
Retinol metabolism	0.35

Arachidonic acid metabolism

	Arachidonic acid metabolism	0.40			Amodiaquine Pathway, Pharmacokinetics	0.00
	Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)	0.00			Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)	0.00

Metabolism

	Metabolism	0.38			Metabolism of lipids and lipoproteins	0.37
	Metabolic pathways	0.38

Find genes that share SuperPaths with CYP1A1 About GenesLikeMe

Pathways by source See SuperPaths
Show all pathways

1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for CYP1A1

AHR Pathway

Selected GeneGo (Thomson Reuters) Pathways for CYP1A1 (see all 7)

	Estradiol metabolism
	Retinol metabolism
	Naphthalene metabolism
	2-Naphthylamine and 2-Nitronaphtalene metabolism
	Benzo[a]pyrene metabolism

Selected BioSystems Pathways for CYP1A1 (see all 9)

	cytochrome P450
	Oxidative Stress
	Tamoxifen metabolism
	Benzo(a)pyrene metabolism
	Estrogen metabolism

4 Reactome Pathways for CYP1A1

	Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)
	Xenobiotics
	PPARA activates gene expression
	Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)

Selected PharmGKB Pathways for CYP1A1 (see all 6)

	Acetaminophen Pathway, Pharmacokinetics
	Amodiaquine Pathway, Pharmacokinetics
	Erlotinib Pathway, Pharmacokinetics
	Estrogen Metabolism Pathway
	Gefitinib Pathway, Pharmacokinetics

Selected Kegg Pathways (Kegg details for CYP1A1) (see all 7):

	Steroid hormone biosynthesis
	Tryptophan metabolism
	Retinol metabolism
	Metabolism of xenobiotics by cytochrome P450
	Metabolic pathways

Pathway & Disease-focused RT² Profiler PCR Arrays including CYP1A1 (see all 6):

Estrogen Receptor Signaling in human mouse rat

Cancer Drug Resistance in human mouse rat

Drug Metabolism: Phase I Enzymes in human mouse rat

Cellular Stress Responses in human mouse rat

Molecular Toxicology PathwayFinder 384HT in human mouse rat

Interactions:

GeneGlobe Interaction Network for CYP1A1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for CYP1A1 (P04798³ ENSP00000369050⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 92)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CYB5A	P00167³, ENSP00000341625⁴	I2D: score=1 STRING: ENSP00000341625
HSPA4	P34932³, ENSP00000302961⁴	I2D: score=1 STRING: ENSP00000302961
HSP90AA1	P07900³, ENSP00000335153⁴	I2D: score=1 STRING: ENSP00000335153
AKR1C1	ENSP00000370254⁴	STRING: ENSP00000370254
AKR1C3	ENSP00000369927⁴	STRING: ENSP00000369927

About this table

Gene Ontology (GO): Selected biological process terms (see all 47): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001666	response to hypoxia	IEA	--
GO:0001889	liver development	--	--
GO:0006778	porphyrin-containing compound metabolic process	IEA	--
GO:0006805	xenobiotic metabolic process	TAS	--
GO:0007568	aging	IEA	--

Find genes that share ontologies with CYP1A1 About GenesLikeMe

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for CYP1A1 (CP1A1)

Selected HMDB Compounds for CYP1A1 (see all 54) About this table

Compound	Synonyms	CAS #	PubMed Ids
Melatonin	5-Methoxy-N-acetyltryptamine (see all 23)	73-31-4	19919601
10-HETE	10-hydroxyeicosa-all-cis-5,8,11,14-tetraenoate (see all 2)	167697-52-1	--
11,12,15-THETA	11,12,15-Trihydroxyicosatrienoic acid (see all 5)	--	--
11,12-Epoxyeicosatrienoic acid	10-(3-(2-octenyl)oxiranyl)-5,8-Decadienoic acid (see all 15)	81276-02-0	--
11,14,15-THETA	(5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoic acid (see all 8)	--	--
11H-14,15-EETA	14,15-Ep-11-HETrE (see all 11)	219535-29-2	--
11beta-Hydroxytestosterone	11beta,17beta-dihydroxyandrost-4-en-3-one	1816-85-9	--
12,13-EpOME	Vernolic acid (see all 12)	--	--
13-HETE	13-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoate (see all 2)	151910-72-4	--
14,15-Epoxy-5,8,11-eicosatrienoic acid	(5Z,8Z,11Z)-14,15-Epoxyicosa-5.8.11-trienoic acid (see all 11)	81276-03-1	--

Selected DrugBank Compounds for CYP1A1 (see all 90) About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Erlotinib	CP358774 (see all 2)	183321-74-6	enzyme	substrate	17575239 16166415 19733976
Melatonin	MEL (see all 4)	73-31-4	enzyme	substrate inhibitor	19919601 15616152 19934256
Tamoxifen	ICI-46474 (see all 3)	10540-29-1	enzyme	substrate	12124303 19934256 19515014
Amiodarone	Amiodarona [INN-Spanish] (see all 5)	1951-25-3	enzyme	substrate	18445370 19934256
Amlodipine	Amlodipine Benzenesulfonate (see all 6)	88150-42-9	enzyme	inhibitor	10805063 19934256
Benzyl alcohol	(Hydroxymethyl)benzene (see all 10)	100-51-6	enzyme	--	9065730 9726784
Chlorzoxazone	Chloroxazone (see all 3)	95-25-0	enzyme	substrate	15231049 20164110
Cinnarizine	--	298-57-7	enzyme	substrate	19934256 19515014
Dasatinib	--	302962-49-8	enzyme	substrate	18556438 19733976
Ellagic Acid	--	476-66-4	enzyme	inhibitor inducer	8024593 19469472

Selected Novoseek inferred chemical compound relationships for CYP1A1 gene (see all 140) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tcdd	94	698	8396892 (9), 15630080 (7), 11728381 (6), 9931287 (6) (see all 99)
ethoxyresorufin	91.1	84	17959138 (4), 8093105 (3), 11599655 (2), 8396892 (1) (see all 67)
benzo(a)pyrene	89.7	376	18372000 (6), 19330882 (6), 16280210 (6), 10503953 (6) (see all 99)
alpha-naphthoflavone	88.1	64	1329656 (4), 12628305 (2), 2115161 (2), 1315629 (1) (see all 38)
3-methylcholanthrene	86.4	193	12941938 (7), 16137816 (4), 17276403 (3), 9465551 (3) (see all 64)
hydrocarbons	85.2	131	8954573 (2), 17630984 (2), 19362136 (2), 8353849 (2) (see all 99)
mspi	84.8	71	1284589 (4), 8706015 (3), 8877059 (3), 8983277 (2) (see all 51)
beta-naphthoflavone	82.9	79	11076701 (3), 12147246 (3), 18502397 (3), 19470599 (3) (see all 36)
4-methoxyestradiol	79.6	1	10403516 (1)
benz(a)anthracene	78.8	30	1700499 (4), 8920757 (2), 1358564 (2), 1654865 (2) (see all 14)

6 PharmGKB related drug/compound annotations for CYP1A1 gene About this table

Drug/compound	PharmGKB Annotation
capecitabine	CA
dexlansoprazole
docetaxel	CA
drospirenone
ethinyl estradiol
tiotropium

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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
About This Section

REFSEQ mRNAs for CYP1A1 gene (2 alternative transcripts):

NM_000499.3 XM_005254185.1

Unigene Cluster for CYP1A1:

Cytochrome P450, family 1, subfamily A, polypeptide 1

Hs.72912 [show with all ESTs]

Unigene Representative Sequence: NM_000499

8 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000379727(uc002ayq.4 uc010bjy.3) ENST00000567032 ENST00000395049

ENST00000562201 ENST00000564596(uc010bjz.1) ENST00000569630 ENST00000566503

ENST00000395048(uc002ayp.4 uc010bju.3 uc010bjv.3 uc010bjw.3 uc010bjx.3)

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		QuantiFast Probe-based Assays in human, mouse, rat CYP1A1

Additional mRNA sequence:

AK223108.1 AK223113.1 AK310810.1 AK313880.1 AM233517.1 AM233518.1 AM233519.1 AM233520.1

AM236046.1 AM236047.1 AY310359.1 AY871801.1 BC023019.1 K03191.1 M12079.1

2 DOTS entries:

DT.310017 DT.100744671

Selected AceView cDNA sequences (see all 52):

AI417887 BU620769 BC023019 AL600919 AV656441 NM_000499 BQ878741 AW451941

AL600881 CA423835 AL600770 AW949660 BQ005861 CB267342 CA439920 BU941041

CB163693 AH007293 CB265483 AA418907 BP353358 CA426401 AL598760 BU182605

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for CYP1A1 About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7a	·	7b
SP1:
SP2:

ECgene alternative splicing isoforms for CYP1A1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CYP1A1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: CTTGCATAAG

About this image

CYP1A1 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 4) fully expand


Liver (Hepatobiliary System)
Perivenous Hepatocytes Liver Lobule

Adipose (Muscoskeletal System) fully expand to see all 2 entries
Interscapular Brown Adipose Depot
HyStem+BMP4-induced 7SMOO32 cells

Lung (Respiratory System)
Basal Cells Respiratory Bronchioles

Placenta (Extraembryonic Tissues)
Syncytiotrophoblast-like cells

CYP1A1 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

CYP1A1 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.72912

UniProtKB/Swiss-Prot: CP1A1_HUMAN, P04798

Tissue specificity: Lung, lymphocytes and placenta

Pathway & Disease-focused RT² Profiler PCR Arrays including CYP1A1 (see all 6):

Estrogen Receptor Signaling in human mouse rat

Cancer Drug Resistance in human mouse rat

Drug Metabolism: Phase I Enzymes in human mouse rat

Cellular Stress Responses in human mouse rat

Molecular Toxicology PathwayFinder 384HT in human mouse rat

Primer Products:		OriGene qPCR primer pairs and template standards for CYP1A1 OriGene qSTAR qPCR primer pairs in human, mouse for CYP1A1
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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYP1A1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for CYP1A1 gene from Selected species (see all 16) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Cyp1a1^{1 , 5}	cytochrome P450, family 1, subfamily a, polypeptide more^{1, 5}	82.61(n)¹ 80.39(a)¹		9 (31.34 cM)⁵ 13076¹ NM_001136059.2¹ NP_001129531.1¹ 57697613⁵
chicken (Gallus gallus)	Aves	CYP1A1¹	cytochrome P450, family 1, subfamily A, polypeptide more	67.06(n) 62.4(a)		396051 NM_205146.2 NP_990477.1
lizard (Anolis carolinensis)	Reptilia	-- -- (see all 3)	Uncharacterized protein (see all 3)	60(a) 58(a) (see all 3)	many ↔ many many ↔ many (see all 3)	GL343721.1(50982-63103) GL343721.1(108802-116982)
African clawed frog (Xenopus laevis)	Amphibia	AB022087.1²	--	71.3(n)		AB022087.1
zebrafish (Danio rerio)	Actinopterygii	cyp1a1²	cytochrome P450, subfamily I, polypeptide 1	74.16(n)		140634 AB078927.1
fruit fly (Drosophila melanogaster)	Insecta	Cyp18a1³	steroid biosynthesis cytochrome P450	32(a) (best of 2)		17D1 --
thale cress (Arabidopsis thaliana)	eudicotyledons	CYP93D1¹	CYP93D1	40.54(n) 28.05(a)		830580 NM_120772.1 NP_196307.1
rice (Oryza sativa)	Liliopsida	Os06g0613600¹	Os06g0613600	45.38(n) 31.3(a)		4341526 NM_001064607.1 NP_001058072.1

ENSEMBL Gene Tree for CYP1A1 (if available)
TreeFam Gene Tree for CYP1A1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
About This Section

Paralogs for CYP1A1 gene

CYP1A2² CYP1B1² CYP17A1² CYP21A2²

Selected SIMAP similar genes for CYP1A1 using alignment to 8 protein entries: CP1A1_HUMAN (see all proteins) (see all similar genes):

CYP1A2 CYP1B1 CYP4V2 CYP2U1 DKFZp686I24235 CYP2D6

CYP2S1 CYP2A13 CYP2A6 CYP2A7 CYP21A2 CYP2F1

CYP2R1 CYP2C8 CYP2J2 CYP2B7 CYP2A6V2 CYP2G1P

Find genes that share paralogs with CYP1A1 About GenesLikeMe

1 Pseudogenes.org Pseudogene for CYP1A1
PGOHUM00000236640

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

SNP ID	Valid	Clinical significance	Chr 15 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs149423266^1,2		--	55062351(+)	`AGGGCA/GTAAGT`	1	--	ds500¹		0	--	--	--	--
rs45627134^1,2	C,F	--	55062527(-)	`CGCAGG/CCACAC`	1	--	ds500¹		5		NS	176
rs79812015^1,2	F	--	55062576(+)	`GAGCCT/CGGAGG`	1	--	ds500¹		1		PA	802
rs4646903^1,2	C,F,A,H	--	55062577(-)	`CCTCCA/C/TGGGCT`	1	--	ds500¹		17		NA MN NS WA CSA EA	934
rs139774860^1,2		--	55062715(+)	`TGCTAC/TCTCCT`	1	--	ds500¹		0	--	--	--	--
rs188913283^1,2	C	--	55062779(+)	`TTAGAC/GGAGTG`	1	--	ds500¹		0	--	--	--	--
rs181716815^1,2		--	55062780(+)	`TAGACA/GAGTGA`	1	--	ds500¹		0	--	--	--	--
rs2472307^1,2	C,H	--	55062791(+)	`TGAATC/TATTTA`	1	--	ds500¹		11		NS EA NA MN	812
rs185383134^1,2		--	55062910(+)	`ATTAAA/CTCAAT`	1	--	ut3¹		0	--	--	--	--
rs17861084^1,2	C,F	--	55062955(+)	`ATGCAG/TGCTAG`	1	--	ut3¹		11		MN NS WA	714

HapMap Linkage Disequilibrium report for CYP1A1 (75011883 - 75017951 bp)

Structural Variations
Database of Genomic Variants (DGV) 4 variations for CYP1A1: About this table

Variant ID	Type	Subtype	PubMed ID
nsv904380	CNV	Loss	21882294
nsv904379	CNV	Loss	21882294
nsv833055	CNV	Loss	17160897
nsv817698	CNV	Gain	17921354

The Human Cytochrome P450 Allele Nomenclature Database: CYP1A1

Human Gene Mutation Database (HGMD): CYP1A1
Locus Specific Mutation Databases (LSDB): CYP1A1

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing CYP1A1

DNA2.0 Custom Variant and Variant Library Synthesis for CYP1A1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
About This Section

OMIM gene information: 108330 OMIM disorders: --

11 diseases for CYP1A1:
About MalaCards

oral cancer cardia cancer lung cancer basal cell carcinoma, multiple

basal cell carcinoma colorectal cancer endometriosis breast cancer

barrett's esophagus leukoplakia prostate cancer

4 inferred disease relationships from the University of Copenhagen DISEASES database for CYP1A1:

Lung cancer Hepatocellular carcinoma Breast cancer Carcinoma

Find genes that share disorders with CYP1A1 About GenesLikeMe

Selected Novoseek inferred disease relationships for CYP1A1 gene (see all 93) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
ahh inducibility	87.7	42	8126925 (5), 8609043 (5), 9465551 (5), 9731718 (4) (see all 10)
cancer lung	68.2	293	9894148 (6), 11778487 (6), 16228113 (6), 10491856 (5) (see all 99)
genetic susceptibility	61.7	23	18304461 (2), 10698723 (1), 19472123 (1), 20054510 (1) (see all 18)
chemical carcinogenesis	58	6	12628305 (1), 19573549 (1), 12520071 (1), 11370663 (1) (see all 6)
cancer	57.9	119	8552885 (3), 15355884 (3), 15805301 (2), 16402077 (2) (see all 91)
breast cancer	57.1	155	9485019 (6), 20088394 (5), 11408954 (5), 16807674 (4) (see all 79)
environmental carcinogenesis	56.6	1	18463401 (1)
oral cancer	46	35	19469619 (5), 17461521 (4), 19160101 (3), 9332761 (3) (see all 10)
adenocarcinoma lung	43.3	14	17200336 (2), 12824892 (2), 15375499 (2), 11955671 (1) (see all 8)
carcinoma squamous cell	43.2	41	11778487 (3), 10435155 (2), 7554077 (2), 10793329 (2) (see all 30)

Genetic Association Database (GAD): CYP1A1
Human Genome Epidemiology (HuGE) Navigator: CYP1A1 (699 documents)

Export disorders for CYP1A1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CYP1A1 gene, integrated from 10 sources (see all 1899):
(articles sorted by number of sources associating them with CYP1A1)

Variation in induced CYP1A1 levels: relationship to CYP1A1, Ah receptor and GSTM1 polymorphisms. (PubMed id 10739168)^{1, 2, 9} Smart J. and Daly A.K. (Pharmacogenetics 2000)
[Relationship between CYP1A1, GSTM1 genetic polymorphisms and susceptibility to esophageal squamous cell carcinoma]. (PubMed id 11860825)^{1, 4, 9} Shao G....Wen B. (Zhonghua Liu Xing Bing Xue Za Zhi 2000)
Evidence for increased cytochrome P450 1A1 expression in blood lymphocytes of lung cancer patients. (PubMed id 19632247)^{1, 4, 9} Shah P.P....Parmar D. (Mutat. Res. 2009)
[Relationship between susceptibility and prognosis of laryngeal cancer and genetic polymorphisms in CYP1A1 and GSTM1]. (PubMed id 15127559)^{1, 4, 9} Li L....Lu H.H. (Zhonghua Er Bi Yan Hou Ke Za Zhi 2004)
CYP1A1 gene polymorphism and risk of epithelial ovarian neoplasm. (PubMed id 12144816)^{1, 4, 9} Aktas D....Ayhan A. (Gynecol. Oncol. 2002)
Possible risk modification by CYP1A1, GSTM1 and GSTT1 gene polymorphisms in lung cancer susceptibility in a South Indian population. (PubMed id 16228113)^{1, 4, 9} Sreeja L....Ankathil R. (J. Hum. Genet. 2005)
[Relationship between CYP1A1 gene polymorphisms and urinary 1-hydroxypyrene levels in coke oven workers]. (PubMed id 19538838)^{1, 4, 9} Nie J.S....Niu Q. (Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2009)
CYP1A1 and GSTM1 polymorphisms and oral cancer risk: association studies via evidence-based meta-analyses. (PubMed id 19160101)^{1, 4, 9} Zhuo W....Chen Z. (Cancer Invest. 2009)
CYP1A1, SULT1A1, and SULT1E1 polymorphisms are risk factors for endometrial cancer susceptibility. (PubMed id 18318428)^{1, 4, 9} Hirata H....Dahiya R. (Cancer 2008)
Riluzole metabolism and CYP1A1/2 polymorphisms in patients with ALS. (PubMed id 17852022)^{1, 4, 9} Ajroud-Driss S....Lukas T.J. (Amyotroph Lateral Scler 2007)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 1543	HGNC: 2595	AceView: CYP1A1	Ensembl:ENSG00000140465	euGenes: HUgn1543
ECgene: CYP1A1	Kegg: 1543	H-InvDB: CYP1A1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CYP1A1	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for CYP1A1	Genetics and Cytogenetics in Oncology and Haematology
Cytochrome P450 Allele Nomenclature Committee	http://www.cypalleles.ki.se/cyp1a1.htm
SHMPD	http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=CYP1A1
Wikipedia	http://en.wikipedia.org/wiki/CYP1A1

Intellectual Property for CYP1A1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for CYP1A1 gene:
Search GeneIP for patents involving CYP1A1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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CYP1A1 Gene

Cytochrome P450, Family 1, Subfamily A, Polypeptide 1

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CYP1A1 (Gene Symbol)
Cytochrome P450, Family 1, Subfamily A, Polypeptide 1
CYP1
Cytochrome P450, Subfamily I (Aromatic Compound-Inducible), Polypeptide 1
Cytochrome P450 Form 6
Cytochrome P450-C
Cytochrome P450-P1
CYPIA1
EC 1.14.14.1
AHH
AHRR
CP11
P1-450
P450-C
P450DX
Aryl Hydrocarbon Hydroxylase
Cytochrome P1-450, Dioxin-Inducible
Cytochrome P450 1A1
Flavoprotein-Linked Monooxygenase
Xenobiotic Monooxygenase

Lymphoblastic Leukemia Acute Childhood
Pregnancy loss
preterm delivery
LUNG TUMOR
Infertility
Genetic Susceptibility
environmental carcinogenesis
Endometriosis
BASAL CELL CARCINOMA, MULTIPLE
Carcinoma Basal Cell
Xeroderma Pigmentosum
Polyps
ADENOCARCINOMA LUNG
COLON CARCINOMA
LUNG CARCINOMA
Liver diseases
Atherosclerosis
Breast Cancer
Metaplasia
primary tumor
NSCLC
Adenocarcinoma
Neck Cancer
cell damage
Cancer
premalignant
Colorectal Carcinoma
Poisoning
Lymphoma
Miscarriage
Leukoplakia
mammary tumor
Shock
Precancerous lesions
Colorectal Cancer
HNSCC
Inflammation
Germ-Line Mutation
TUMOR LIVER
adult brain tumor
chemical carcinogenesis
Oral Cancer
Cervical Cancer
Pulmonary Disease Chronic Obstructive
prostate cancer
Pneumonia
Tumors
Cardiovascular Diseases
Metastasis
Lymphoblastic Leukemia Acute
Necrosis
Carcinoma Bronchogenic
SMOKING HABIT
Hepatitis C
Chronic Disease
Gastric Cancer
Barrett Esophagus
Cirrhosis
BREAST CARCINOMA
Melanoma
Colon Cancer
bladder cancer
Parkinson Disease
ESOPHAGEAL CARCINOMA
Glioma
Carcinoma
Leukemia
Osteoporosis
Laryngeal Cancer
HEPATOCELLULAR CARCINOMA
Calcification
AHH INDUCIBILITY
laryngeal squamous cell carcinoma
Carcinoma Renal Cell
AML adult
chemically induced
Cancer Lung
small cell lung cancer
Coronary Artery Disease
Wasting Syndrome
Skin Cancer
NASOPHARYNGEAL CARCINOMA
Adenoma
benign prostatic hyperplasia
OVARIAN CARCINOMA
Carcinoma Squamous Cell
Chromosomal Aberrations
chronic liver disease
Lymphoma Non-Hodgkins
leukemogenesis
Breast Diseases
Endometrial Cancer
Lupus Erythematosus Systemic

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CYP1A1 Gene

Cytochrome P450, Family 1, Subfamily A, Polypeptide 1

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