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Aliases for CYP1A1 Gene

Aliases for CYP1A1 Gene

  • Cytochrome P450, Family 1, Subfamily A, Polypeptide 1 2 3
  • Cytochrome P450, Subfamily I (Aromatic Compound-Inducible), Polypeptide 1 2 3
  • Cytochrome P450 Form 6 3 4
  • Cytochrome P450-P1 3 4
  • Cytochrome P450-C 3 4
  • EC 4 63
  • CYPIA1 3 4
  • CYP1 3 6
  • Cytochrome P1-450, Dioxin-Inducible 3
  • Flavoprotein-Linked Monooxygenase 3
  • Aryl Hydrocarbon Hydroxylase 3
  • Xenobiotic Monooxygenase 3
  • Cytochrome P450 1A1 3
  • P1-450 3
  • P450-C 3
  • P450DX 3
  • AhRR 3
  • CP11 3
  • AHH 3

External Ids for CYP1A1 Gene

Previous Symbols for CYP1A1 Gene

  • CYP1

Summaries for CYP1A1 Gene

Entrez Gene Summary for CYP1A1 Gene

  • This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15. [provided by RefSeq, Jul 2008]

GeneCards Summary for CYP1A1 Gene

CYP1A1 (Cytochrome P450, Family 1, Subfamily A, Polypeptide 1) is a Protein Coding gene. Diseases associated with CYP1A1 include basal cell carcinoma, multiple and oral cancer. Among its related pathways are AhR pathway (WikiPathways) and Metabolism. GO annotations related to this gene include enzyme binding and iron ion binding. An important paralog of this gene is CYP21A2.

UniProtKB/Swiss-Prot for CYP1A1 Gene

  • Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics

Gene Wiki entry for CYP1A1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYP1A1 Gene

Genomics for CYP1A1 Gene

Genomic Location for CYP1A1 Gene

74,719,542 bp from pter
74,725,610 bp from pter
6,069 bases
Minus strand

Genomic View for CYP1A1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CYP1A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYP1A1 Gene

Regulatory Elements for CYP1A1 Gene

Proteins for CYP1A1 Gene

  • Protein details for CYP1A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cytochrome P450 1A1
    Protein Accession:
    Secondary Accessions:
    • A4F3V9
    • A4F3W0
    • Q53G18

    Protein attributes for CYP1A1 Gene

    512 amino acids
    Molecular mass:
    58165 Da
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CYP1A1 Gene

    Alternative splice isoforms for CYP1A1 Gene


neXtProt entry for CYP1A1 Gene

Proteomics data for CYP1A1 Gene at MOPED

Post-translational modifications for CYP1A1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CYP1A1 Gene

Domains for CYP1A1 Gene

Gene Families for CYP1A1 Gene

  • CYP :Cytochrome P450s

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the cytochrome P450 family.:
    • P04798
genes like me logo Genes that share domains with CYP1A1: view

Function for CYP1A1 Gene

Molecular function for CYP1A1 Gene

GENATLAS Biochemistry: cytochrome p450,family I (polycytic aromatic compound-inducible),member A1 (see CYP1@),associated with susceptibility to lung squamous cell carcinoma and to childhood acute lymphoblastic leukemia (in association with deletion of GSTM1)
UniProtKB/Swiss-Prot CatalyticActivity: RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O
UniProtKB/Swiss-Prot Function: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics
UniProtKB/Swiss-Prot Induction: By 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)

Enzyme Numbers (IUBMB) for CYP1A1 Gene

Gene Ontology (GO) - Molecular Function for CYP1A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004497 monooxygenase activity --
GO:0005506 iron ion binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0008395 steroid hydroxylase activity IEA --
genes like me logo Genes that share ontologies with CYP1A1: view
genes like me logo Genes that share phenotypes with CYP1A1: view

Animal Models for CYP1A1 Gene

MGI Knock Outs for CYP1A1:

miRNA for CYP1A1 Gene

miRTarBase miRNAs that target CYP1A1

No data available for Transcription Factor Targeting and HOMER Transcription for CYP1A1 Gene

Localization for CYP1A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYP1A1 Gene

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Subcellular locations from

Jensen Localization Image for CYP1A1 Gene COMPARTMENTS Subcellular localization image for CYP1A1 gene
Compartment Confidence
endoplasmic reticulum 5
nucleus 3
cytosol 2
mitochondrion 2
cytoskeleton 1
extracellular 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CYP1A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm --
GO:0005739 mitochondrion IEA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0043231 intracellular membrane-bounded organelle --
genes like me logo Genes that share ontologies with CYP1A1: view

Pathways for CYP1A1 Gene

genes like me logo Genes that share pathways with CYP1A1: view

Gene Ontology (GO) - Biological Process for CYP1A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001666 response to hypoxia IEA --
GO:0001889 liver development --
GO:0006778 porphyrin-containing compound metabolic process IEA --
GO:0006805 xenobiotic metabolic process TAS --
GO:0007568 aging IEA --
genes like me logo Genes that share ontologies with CYP1A1: view

Compounds for CYP1A1 Gene

(54) HMDB Compounds for CYP1A1 Gene

Compound Synonyms Cas Number PubMed IDs
  • 10-hydroxyeicosa-all-cis-5,8,11,14-tetraenoate
  • 11,12,15-Trihydroxyicosatrienoic acid
Not Available
11,12-Epoxyeicosatrienoic acid
  • 10-(3-(2-octenyl)oxiranyl)-5,8-Decadienoic acid
  • (5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoic acid
Not Available
  • 11beta,17beta-dihydroxyandrost-4-en-3-one

(90) Drugbank Compounds for CYP1A1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
  • Acetaminofen
103-90-2 enzyme substrate
54965-21-8 enzyme inducer
  • Amiodarona [INN-Spanish]
1951-25-3 enzyme substrate
  • Amlodipine Benzenesulfonate
88150-42-9 enzyme inhibitor
  • Amodiaquin
86-42-0 enzyme substrate

(140) Novoseek inferred chemical compound relationships for CYP1A1 Gene

Compound -log(P) Hits PubMed IDs
tcdd 94 304
ethoxyresorufin 91.1 73
benzo(a)pyrene 89.7 209
alpha-naphthoflavone 88.1 43
3-methylcholanthrene 86.4 103

(6) PharmGKB related drug/compound annotations for CYP1A1 Gene

genes like me logo Genes that share compounds with CYP1A1: view

Transcripts for CYP1A1 Gene

Unigene Clusters for CYP1A1 Gene

Cytochrome P450, family 1, subfamily A, polypeptide 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CYP1A1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b

Relevant External Links for CYP1A1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CYP1A1 Gene

mRNA expression in normal human tissues for CYP1A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CYP1A1 Gene

This gene is overexpressed in Liver (8.2), Lung (5.5), Adipose - Subcutaneous (5.0), and Skin - Sun Exposed (Lower leg) (4.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CYP1A1 Gene

SOURCE GeneReport for Unigene cluster for CYP1A1 Gene Hs.72912

mRNA Expression by UniProt/SwissProt for CYP1A1 Gene

Tissue specificity: Lung, lymphocytes and placenta
genes like me logo Genes that share expressions with CYP1A1: view

Orthologs for CYP1A1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CYP1A1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CYP1A1 36
  • 100 (a)
LOC453744 35
  • 99.67 (n)
  • 99.8 (a)
(Bos Taurus)
Mammalia CYP1A1 35
  • 85.42 (n)
  • 81.18 (a)
CYP1A1 36
  • 80 (a)
(Canis familiaris)
Mammalia CYP1A1 35
  • 84.65 (n)
  • 82.09 (a)
CYP1A1 36
  • 80 (a)
(Mus musculus)
Mammalia Cyp1a1 35
  • 82.61 (n)
  • 80.39 (a)
Cyp1a1 16
Cyp1a1 36
  • 78 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 72 (a)
-- 36
  • 59 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 70 (a)
(Rattus norvegicus)
Mammalia Cyp1a1 35
  • 82.42 (n)
  • 79.61 (a)
(Gallus gallus)
Aves CYP1A1 35
  • 67.06 (n)
  • 62.4 (a)
CYP1A1 36
  • 60 (a)
CYP1A4 36
  • 58 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 55 (a)
-- 36
  • 58 (a)
-- 36
  • 60 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cyp1a1 35
  • 65.14 (n)
  • 63.22 (a)
Str.2144 35
(Danio rerio)
Actinopterygii cyp1a 35
  • 60.88 (n)
  • 57.88 (a)
cyp1a 36
  • 55 (a)
cyp1a1 35
fruit fly
(Drosophila melanogaster)
Insecta spo 36
  • 24 (a)
spok 36
  • 22 (a)
Cyp307a1 37
  • 28 (a)
Cyp18a1 37
  • 32 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons CYP93D1 35
  • 40.54 (n)
  • 28.05 (a)
(Oryza sativa)
Liliopsida Os06g0613600 35
  • 45.38 (n)
  • 31.3 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 31 (a)
-- 36
  • 21 (a)
Species with no ortholog for CYP1A1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CYP1A1 Gene

Gene Tree for CYP1A1 (if available)
Gene Tree for CYP1A1 (if available)

Paralogs for CYP1A1 Gene

Paralogs for CYP1A1 Gene Pseudogenes for CYP1A1 Gene

genes like me logo Genes that share paralogs with CYP1A1: view

Variants for CYP1A1 Gene

Sequence variations from dbSNP and Humsavar for CYP1A1 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs1048943 - 74,720,644(-) AGACC(A/C/G/T)TTGCC reference, missense
rs1799814 - 74,720,646(-) TGAGA(A/C)CATTG missense, reference
rs1800031 -- 74,719,894(-) CCTTC(C/T)GGCCT utr-variant-3-prime
rs2229150 - 74,722,821(-) CCATC(C/T)GGCAG reference, missense
rs2278970 -- 74,720,640(+) AGCGG(C/G)CAAYG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for CYP1A1 Gene

Variant ID Type Subtype PubMed ID
nsv904379 CNV Loss 21882294
nsv904380 CNV Loss 21882294
nsv817698 CNV Gain 17921354
nsv833055 CNV Loss 17160897

Relevant External Links for CYP1A1 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)
Locus Specific Mutation Databases (LSDB)
The Human Cytochrome P450 Allele Nomenclature Database

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CYP1A1 Gene

Disorders for CYP1A1 Gene

(4) University of Copenhagen DISEASES for CYP1A1 Gene

(93) Novoseek inferred disease relationships for CYP1A1 Gene

Disease -log(P) Hits PubMed IDs
ahh inducibility 87.7 27
cancer lung 68.2 225
genetic susceptibility 61.7 19
chemical carcinogenesis 58 6
cancer 57.9 106

Relevant External Links for CYP1A1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with CYP1A1: view

No data available for UniProtKB/Swiss-Prot for CYP1A1 Gene

Publications for CYP1A1 Gene

  1. Variation in induced CYP1A1 levels: relationship to CYP1A1, Ah receptor and GSTM1 polymorphisms. (PMID: 10739168) Smart J. … Daly A.K. (Pharmacogenetics 2000) 3 4 23
  2. Relation between inducibility of CYP1A1, GSTM1 and lung cancer in a French population. (PMID: 11037803) StA1cker I. … HAcmon D. (Pharmacogenetics 2000) 3 23 48
  3. Association of CYP1A1 germ line polymorphisms with mutations of the p53 gene in lung cancer. (PMID: 8548778) Kawajiri K. … Yamamoto M. (Cancer Res. 1996) 3 23 48
  4. Genetic polymorphisms in cytochrome P450 (CYP) 1A1, CYP1A2, CYP2E1, glutathione S-transferase (GST) M1 and GSTT1 and susceptibility to prostate cancer in the Japanese population. (PMID: 11275366) Murata M. … Shiraishi T. (Cancer Lett. 2001) 3 23 48
  5. [Polymorphisms of the CYP1A1 and GSTM1 genes and their combined effects on individual susceptibility to lung cancer in a Chinese population]. (PMID: 11295132) Xue K. … Wu J. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2001) 3 23 48

Products for CYP1A1 Gene

Sources for CYP1A1 Gene

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