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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CYP1A1 Gene

protein-coding GIFtS: 71
GCID: GC15M075011

cytochrome P450, family 1, subfamily A, polypeptide 1

(Previous names: cytochrome P450, subfamily I (aromatic compound-inducible),...)
(Previous symbol: CYP1)

Explore 185 diseases affiliated with
CYP1A1 via

MalaCards

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Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Cytochrome P450, Family 1, Subfamily A, Polypeptide 1¹ ²		CYPIA1² ³
CYP1¹ ² ⁵		EC 1.14.14.1³ ⁸
CP11¹ ²		AHH²
P1-450¹ ²		AHRR²
P450-C¹ ²		Aryl Hydrocarbon Hydroxylase²
P450DX¹ ²		Cytochrome P1-450, Dioxin-Inducible²
Cytochrome P450, Subfamily I (Aromatic Compound-Inducible), Polypeptide 1¹ ²		Cytochrome P450 1A1²
Cytochrome P450 Form 6² ³		Flavoprotein-Linked Monooxygenase²
Cytochrome P450-C² ³		Xenobiotic Monooxygenase²
Cytochrome P450-P1² ³

External Ids:	HGNC: 2595¹	Entrez Gene: 1543²	Ensembl: ENSG00000140465⁷	OMIM: 108330⁵	UniProtKB: P04798³

Export aliases for CYP1A1 gene to outside databases

Previous GC identifers: GC15M068848 GC15M068126 GC15M072587 GC15M072727 GC15M072798 GC15M051809

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CYP1A1:

This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are

monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and

other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic

aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is

unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with

lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15.

(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CP1A1_HUMAN, P04798

Function: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in

an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including

steroids, fatty acids, and xenobiotics

Gene Wiki entry for CYP1A1 (Cytochrome P450, family 1, member A1)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000015.9 NC_018926.1 NT_010194.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CYP1A1 gene promoter:
GR C/EBPbeta p53 SREBP-1c Bach2 SREBP-1b HNF-4alpha1 MZF-1 SREBP-1a GR-alpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): CYP1A1 promoter sequence

Search SABiosciences Chromatin IP Primers for CYP1A1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CYP1A1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q24.1 Ensembl cytogenetic band: 15q24.1 HGNC cytogenetic band: 15q24.1

CYP1A1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CYP1A1 gene location

GeneLoc information about chromosome 15 GeneLoc Exon Structure

GeneLoc location for GC15M075011: view genomic region (about GC identifiers)

Start:	75,011,883 bp from pter	End:	75,017,951 bp from pter
Size:	6,069 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CP1A1_HUMAN, P04798 (See protein sequence)

Recommended Name: Cytochrome P450 1A1

Size: 512 amino acids; 58165 Da

Cofactor: Heme group (By similarity)

Subcellular location: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral

membrane protein

Secondary accessions: Q53G18

Explore the universe of human proteins at neXtProt for CYP1A1: NX_P04798

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P04798

4/25 DME Specific Peptides for CYP1A1 (P04798) (see all 25)

FSIASDP

PILRYLP

NQWQINH

ELDTVIG

CYP1A1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_000490.1

ENSEMBL proteins:

ENSP00000369050 ENSP00000456585 ENSP00000378489 ENSP00000455340 ENSP00000457668

ENSP00000455051 ENSP00000455846 ENSP00000378488

Reactome Protein details: P04798
Human Recombinant Protein Products for CYP1A1:

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	Novus Biologicals CYP1A1 Protein Novus Biologicals CYP1A1 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for CYP1A1

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	--	--
GO:0005739	mitochondrion	IEA	--
GO:0005789	endoplasmic reticulum membrane	TAS	--
GO:0005792	microsome	--	--

CYP1A1 for ontologies About GeneDecksing

CYP1A1 Antibody Products:

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	Novus Biologicals CYP1A1 Antibodies
	Abcam antibodies for CYP1A1
	Uscn Antibodies for CYP1A1
	ThermoFisher Antibody for CYP1A1

Assay Products for CYP1A1:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for CYP1A1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CYP1A1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CYP1A1 for domains About GeneDecksing

4 InterPro domains/families:

IPR001128 Cyt_P450

IPR017972 Cyt_P450_CS

IPR002401 Cyt_P450_E_grp-I

IPR008066 Cyt_P450_E_grp-I_CYP1

Graphical View of Domain Structure for InterPro Entry P04798

ProtoNet protein and cluster: P04798

2 Blocks protein families:

IPB002401 E-class P450 group I signature

IPB008066 CYP1A P450 family signature

UniProtKB/Swiss-Prot: CP1A1_HUMAN, P04798

Similarity: Belongs to the cytochrome P450 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: CP1A1_HUMAN, P04798

Function: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in

an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including

steroids, fatty acids, and xenobiotics

Catalytic activity: RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O

Induction: By 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)

Genatlas biochemistry entry for CYP1A1:

cytochrome p450,family I (polycytic aromatic compound-inducible),member A1 (see CYP1@),associated with susceptibility

to lung squamous cell carcinoma and to childhood acute lymphoblastic leukemia (in association with deletion of GSTM1)

Enzyme Number (IUBMB): EC 1.14.14.1¹ ²

Gene Ontology (GO): 5/16 molecular function terms (GO ID links to tree view) (see all 16): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003824	catalytic activity	--	--
GO:0004497	monooxygenase activity	--	--
GO:0005506	iron ion binding	IEA	--
GO:0005515	protein binding	--	--
GO:0008395	steroid hydroxylase activity	IEA	--

CYP1A1 for ontologies About GeneDecksing

Phenotypes:
9 MGI mutant phenotypes (inferred from 7 alleles) (MGI details for Cyp1a1):

cardiovascular system	growth/size	hematopoietic system	homeostasis/metabolism	immune system
liver/biliary system	mortality/aging	no phenotypic analysis	normal

CYP1A1 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-outs for CYP1A1: Cyp1a1^tm1.1Dwn Cyp1a2/Cyp1a1^{Cyp1a2/tm2Dwn} Cyp1a2/Cyp1a1^{Cyp1a2/tm1.1Bra}

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for CYP1A1

miRNA Products:		OriGene 3'-UTR Clone: CYP1A1 Browse MicroRNA Expression Plasmids
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		SwitchGear 3'UTR luciferase reporter plasmid: CYP1A1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CYP1A1 (see all 7) OriGene shRNA RFP: CYP1A1 OriGene siRNA: CYP1A1
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		Sirion Biotech Custom design and validation of potent shRNA sequences against CYP1A1

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for CYP1A1
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Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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		GenScript: all cDNA clones in your preferred vector: CYP1A1 (NM_000499)
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CYP1A1
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYP1A1

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/20 super-pathways (see all 20) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)

Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)	1.00	Benzo[a]pyrene metabolism	0.33
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)	0.55	Benzo[a]pyrene metabolism	0.33
Warfarin Pathway, Pharmacokinetics	0.45	Expression of CYP1A1	0.12
Amodiaquine Pathway, Pharmacokinetics	0.38

Acetaminophen Pathway, Pharmacokinetics

	Pathway_PA165986194 -need delete	1.00			Acetaminophen metabolism	0.43
	Acetaminophen Pathway, Pharmacokinetics	1.00			Acetaminophen metabolism	0.43

Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)

	Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)	1.00			Fatty acid, triacylglycerol, and ketone body metabolism	0.52
	PPARA Activates Gene Expression	0.74

Cytochrome P450 - arranged by substrate type

	Cytochrome P450 - arranged by substrate type	1.00			cytochrome P450	0.73
	Phase 1 - Functionalization of compounds	0.74

Metabolism

	Metabolism	1.00			Metabolism of lipids and lipoproteins	0.34
	Metabolic pathways	0.38

Pathway sources
See GeneCards unified pathways
Show all pathways

7 EMD Millipore Pathways for CYP1A1 (see first 5)

	Androstenedione and testosterone biosynthesis and metabolism p.1
	Estradiol metabolism
	2-Naphthylamine and 2-Nitronaphtalene metabolism
	Retinol metabolism
	Naphthalene metabolism
	Acetaminophen metabolism
	Benzo[a]pyrene metabolism

5/7 GeneGo (Thomson Reuters) Pathways for CYP1A1 (see all 7)

	Estradiol metabolism
	Retinol metabolism
	Naphthalene metabolism
	2-Naphthylamine and 2-Nitronaphtalene metabolism
	Benzo[a]pyrene metabolism

5/8 BioSystems Pathways for CYP1A1 (see all 8)

	cytochrome P450
	Estrogen metabolism
	Benzo(a)pyrene metabolism
	Tamoxifen metabolism
	Fatty Acid Omega Oxidation

5/13 Reactome Pathways for CYP1A1 (see all 13)

	Cytochrome P450 - arranged by substrate type
	Xenobiotics
	Metabolism
	Arachidonic acid metabolism
	Fatty acid, triacylglycerol, and ketone body metabolism

5/7 PharmGKB Pathways for CYP1A1 (see all 7)

	Acetaminophen Pathway, Pharmacokinetics
	Amodiaquine Pathway, Pharmacokinetics
	Erlotinib Pathway, Pharmacokinetics
	Estrogen Metabolism Pathway
	Gefitinib Pathway, Pharmacokinetics

5 Kegg Pathways (Kegg details for CYP1A1):

	Steroid hormone biosynthesis
	Tryptophan metabolism
	Retinol metabolism
	Metabolism of xenobiotics by cytochrome P450
	Metabolic pathways

CYP1A1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CYP1A1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/90 Interacting proteins for CYP1A1 (P04798³ ENSP00000369050⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 90)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CYB5A	P00167³, ENSP00000341625⁴	I2D: score=1 STRING: ENSP00000341625
HSP90AA1	P07900³	I2D: score=1
HSPA4	P34932³	I2D: score=1
AKR1C1	ENSP00000370254⁴	STRING: ENSP00000370254
AKR1C3	ENSP00000369927⁴	STRING: ENSP00000369927

About this table

Gene Ontology (GO): 5/45 biological process terms (GO ID links to tree view) (see all 45): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001666	response to hypoxia	IEA	--
GO:0001889	liver development	--	--
GO:0006778	porphyrin-containing compound metabolic process	IEA	--
GO:0006805	xenobiotic metabolic process	TAS	--
GO:0006950	response to stress	--	--

CYP1A1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CYP1A1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CYP1A1

10/54 HMDB Compounds for CYP1A1 (see all 54) About this table

Compound	Synonyms	CAS #	PubMed Ids
Melatonin	5-Methoxy-N-acetyltryptamine (see all 23)	73-31-4	19919601
10-HETE	10-hydroxyeicosa-all-cis-5,8,11,14-tetraenoate (see all 2)	167697-52-1	--
11,12,15-THETA	11,12,15-Trihydroxyicosatrienoic acid (see all 5)	--	--
11,12-Epoxyeicosatrienoic acid	10-(3-(2-octenyl)oxiranyl)-5,8-Decadienoic acid (see all 15)	81276-02-0	--
11,14,15-THETA	(5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoic acid (see all 8)	--	--
11H-14,15-EETA	14,15-Ep-11-HETrE (see all 11)	219535-29-2	--
11beta-Hydroxytestosterone	11beta,17beta-dihydroxyandrost-4-en-3-one	1816-85-9	--
12,13-EpOME	Vernolic acid (see all 12)	--	--
13-HETE	13-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoate (see all 2)	151910-72-4	--
14,15-Epoxy-5,8,11-eicosatrienoic acid	(5Z,8Z,11Z)-14,15-Epoxyicosa-5.8.11-trienoic acid (see all 11)	81276-03-1	--

10/83 DrugBank Compounds for CYP1A1 (see all 83) About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Erlotinib	--	183321-74-6	enzyme	substrate	17575239 16166415 19733976
Melatonin	MEL (see all 4)	73-31-4	enzyme	substrate inhibitor	19919601 15616152 19934256
Tamoxifen	Tamoxifen Citrate (see all 5)	10540-29-1	enzyme	substrate	12124303 19934256 19515014
Amiodarone	Amiodarona [INN-Spanish] (see all 5)	1951-25-3	enzyme	substrate	18445370 19934256
Amlodipine	Amlodipine Benzenesulfonate (see all 6)	88150-42-9	enzyme	inhibitor	10805063 19934256
Chlorzoxazone	Chloroxazone (see all 3)	95-25-0	enzyme	substrate	15231049 20164110
Cinnarizine	--	298-57-7	enzyme	substrate	19934256 19515014
Dasatinib	--	302962-49-8	enzyme	substrate	18556438 19733976
Flunarizine	(E)-1-[Bis-(p-fluorophenyl)methyl]-4-cinnamylpiperazine (see all 6)	52468-60-7	enzyme	substrate	19934256 19515014
Fluvastatin	Fluindostatin (see all 5)	93957-54-1	enzyme	substrate	19934256 19515014

10/140 Novoseek chemical compound relationships for CYP1A1 gene (see all 140) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tcdd	94	698	8396892 (9), 15630080 (7), 11728381 (6), 9931287 (6) (see all 99)
ethoxyresorufin	91.1	84	17959138 (4), 8093105 (3), 11599655 (2), 8396892 (1) (see all 67)
benzo(a)pyrene	89.7	376	18372000 (6), 19330882 (6), 16280210 (6), 10503953 (6) (see all 99)
alpha-naphthoflavone	88.1	64	1329656 (4), 12628305 (2), 2115161 (2), 1315629 (1) (see all 38)
3-methylcholanthrene	86.4	193	12941938 (7), 16137816 (4), 17276403 (3), 9465551 (3) (see all 64)
hydrocarbons	85.2	131	8954573 (2), 17630984 (2), 19362136 (2), 8353849 (2) (see all 99)
mspi	84.8	71	1284589 (4), 8706015 (3), 8877059 (3), 8983277 (2) (see all 51)
beta-naphthoflavone	82.9	79	11076701 (3), 12147246 (3), 18502397 (3), 19470599 (3) (see all 36)
4-methoxyestradiol	79.6	1	10403516 (1)
benz(a)anthracene	78.8	30	1700499 (4), 8920757 (2), 1358564 (2), 1654865 (2) (see all 14)

Search CenterWatch for drugs/clinical trials and news about CYP1A1 / CP1A1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CYP1A1 gene:

NM_000499.3

Unigene Cluster for CYP1A1:

Cytochrome P450, family 1, subfamily A, polypeptide 1

Hs.72912 [show with all ESTs]

Unigene Representative Sequence: NM_000499

8 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000379727(uc002ayq.4 uc010bjy.3) ENST00000567032 ENST00000395049

ENST00000562201 ENST00000564596(uc010bjz.1) ENST00000569630 ENST00000566503

ENST00000395048(uc002ayp.4 uc010bju.3 uc010bjv.3 uc010bjw.3 uc010bjx.3)

miRNA Products:		OriGene 3'-UTR Clone: CYP1A1 Browse OriGene MicroRNA Expression Plasmids
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Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		Sirion Biotech Custom design and validation of potent shRNA sequences against CYP1A1

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		GenScript: all cDNA clones in your preferred vector: CYP1A1 (NM_000499)
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CYP1A1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CYP1A1

Additional cDNA sequence:

AK223108.1 AK223113.1 AK310810.1 AK313880.1 AM233517.1 AM233518.1 AM233519.1 AM233520.1

AM236046.1 AM236047.1 AY310359.1 AY871801.1 BC023019.1 K03191.1 M12079.1

2 DOTS entries:

DT.310017 DT.100744671

24/52 AceView cDNA sequences (see all 52):

BC023019 AV656441 AW451941 BQ005861 AI417887 AW949660 AL600919 AL600881

AL600770 NM_000499 BQ878741 BU620769 CA423835 BI254564 AI745534 CB267342

BP353358 CB265483 AW291515 M12079 BU182605 AH007293 AL598658 BF593495

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for CYP1A1 About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7a	·	7b
SP1:
SP2:

ECgene alternative splicing isoforms for CYP1A1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CYP1A1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTTGCATAAG

About this image

CYP1A1 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Liver

Liver Lobule

Perivenous Hepatocytes

Selective marker (cell-identifying gene)

Liver

Adipose

Interscapular Brown Adipose Depot

Adipose

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 5 LifeMap Cells

Name

Category

PureStem™ endothelial progenitor 30-MV2-12 (Embryonic Progenitor Cell)

Blood, Endothelium

PureStem™ endothelial Progenitor 30-SM2-3 (Embryonic Progenitor Cell)

Blood, Endothelium

PureStem™ endothelial progenitor 30-MV2-14 (Embryonic Progenitor Cell)

Endothelium

Syncytiotrophoblast-like cells (Generation of syncyt...)

HyStem+BMP4-induced 7SMOO32 cells (HyStem+BMP4 inductio...)

Adipose

See CYP1A1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CYP1A1

SOURCE GeneReport for Unigene cluster: Hs.72912

UniProtKB/Swiss-Prot: CP1A1_HUMAN, P04798

Tissue specificity: Lung, lymphocytes and placenta

SABiosciences Expression via Pathway-Focused PCR Arrays including CYP1A1 (see all 6):

Estrogen Receptor Signaling in human mouse rat

Cancer Drug Resistance in human mouse rat

Drug Metabolism: Phase I Enzymes in human mouse rat

Cellular Stress Responses in human mouse rat

Molecular Toxicology PathwayFinder 384HT in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CYP1A1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CYP1A1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CYP1A1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CYP1A1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYP1A1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for CYP1A1 gene from 7/22 species (see all 22) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	CYP1A1¹	cytochrome P450, family 1, subfamily A, polypeptide more	67.06(n) 62.4(a)		396051 NM_205146.1 NP_990477.1
lizard (Anolis carolinensis)	Reptilia	-- -- (see all 3)	--	59(a) 58(a) (see all 3)	many ↔ many many ↔ many (see all 3)	GL343721.1(52577-61909) GL343721.1(108864-116106)
African clawed frog (Xenopus laevis)	Amphibia	AB022087.1²	--	71.3(n)		AB022087.1
zebrafish (Danio rerio)	Actinopterygii	cyp1a1²	cytochrome P450, subfamily I, polypeptide 1	74.16(n)		140634 AB078927.1
fruit fly (Drosophila melanogaster)	Insecta	Cyp18a1³	steroid biosynthesis cytochrome P450	32(a) (best of 2)		17D1 --
thale cress (Arabidopsis thaliana)	eudicotyledons	CYP93D1¹	cytochrome P450, family 93, subfamily D, polypeptide more	41.25(n) 28.29(a)		830580 NM_120772.1 NP_196307.1
rice (Oryza sativa)	Liliopsida	Os06g0613600¹	hypothetical protein	46.09(n) 32.35(a)		4341526 NM_001064607.1 NP_001058072.1

ENSEMBL Gene Tree for CYP1A1 (if available)
TreeFam Gene Tree for CYP1A1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CYP1A1 gene

CYP1B1² CYP1A2² CYP17A1² CYP2G1P² ENSG00000198251² CYP21A2²

18/30 SIMAP similar genes for CYP1A1 using alignment to 10 protein entries: CP1A1_HUMAN (see all proteins) (see all similar genes):

CYP1A2 CYP1B1 CYP2U1 CYP4V2 DKFZp686I24235 CYP2D6

CYP21A2 CYP2A7 CYP2A13 CYP2A6 CYP2C9 CYP2S1

CYP2C8 CYP2R1 CYP2B7 CYP2F1 CYP2J2 CYP2A6V2

CYP1A1 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for CYP1A1
PGOHUM00000236640

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 15 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs149423266^1,2		--	75011415(+)	`AGGGCA/GTAAGT`	1	--	ds500¹		0	--	--	--	--
rs45627134^1,2	C	--	75011591(-)	`CGCAGG/CCACAC`	1	--	ds500¹		5		NS	176
rs79812015^1,2	F	--	75011640(+)	`GAGCCT/CGGAGG`	1	--	ds500¹		1		PA	802
rs4646903^1,2	C,F,A,H	--	75011641(-)	`CCTCCA/C/TGGGCT`	1	--	ds500¹		17		NA MN NS WA CSA EA	934
rs139774860^1,2		--	75011779(+)	`TGCTAC/TCTCCT`	1	--	ds500¹		0	--	--	--	--
rs188913283^1,2		--	75011843(+)	`TTAGAC/GGAGTG`	1	--	ds500¹		0	--	--	--	--
rs181716815^1,2		--	75011844(+)	`TAGACA/GAGTGA`	1	--	ds500¹		0	--	--	--	--
rs2472307^1,2	C,H	--	75011855(+)	`TGAATC/TATTTA`	1	--	ds500¹		11		NS EA NA MN	812
rs185383134^1,2		--	75011974(+)	`ATTAAA/CTCAAT`	1	--	ut3¹		0	--	--	--	--
rs17861084^1,2	C,F	--	75012019(+)	`ATGCAG/TGCTAG`	1	--	ut3¹		11		MN NS WA	714

HapMap Linkage Disequilibrium report for CYP1A1 (75011883 - 75017951 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for CYP1A1
1 CNV: 9749
1 Inversion: 37170
Human Gene Mutation Database (HGMD): CYP1A1

Locus Specific Mutation Databases (LSDB): CYP1A1

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CYP1A1

DNA2.0 Custom Variant and Variant Library Synthesis for CYP1A1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CYP1A1 for disorders           About GeneDecksing

OMIM gene information: 108330    OMIM disorders: --

20/185 diseases for CYP1A1 (see all 185):    About MalaCards

lung cancer porphyria cutanea tarda diffuse large b-cell lymphoma sudden infant death syndrome

squamous cell carcinoma non-small cell lung carcinoma basal cell carcinoma, multiple b-cell lymphomas

barrett's esophagus laryngeal squamous cell carcinoma pre-eclampsia basal cell carcinoma

testicular germ cell tumor malignant pleural mesothelioma cholesterol intrahepatic cholestasis

4 diseases from the University of Copenhagen DISEASES database for CYP1A1:

Lung cancer Hepatocellular carcinoma Breast cancer Carcinoma

10/93 Novoseek disease relationships for CYP1A1 gene (see all 93) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
ahh inducibility	87.7	42	8126925 (5), 8609043 (5), 9465551 (5), 9731718 (4) (see all 10)
cancer lung	68.2	293	9894148 (6), 11778487 (6), 16228113 (6), 10491856 (5) (see all 99)
genetic susceptibility	61.7	23	18304461 (2), 10698723 (1), 19472123 (1), 20054510 (1) (see all 18)
chemical carcinogenesis	58	6	12628305 (1), 19573549 (1), 12520071 (1), 11370663 (1) (see all 6)
cancer	57.9	119	8552885 (3), 15355884 (3), 15805301 (2), 16402077 (2) (see all 91)
breast cancer	57.1	155	9485019 (6), 20088394 (5), 11408954 (5), 16807674 (4) (see all 79)
environmental carcinogenesis	56.6	1	18463401 (1)
oral cancer	46	35	19469619 (5), 17461521 (4), 19160101 (3), 9332761 (3) (see all 10)
adenocarcinoma lung	43.3	14	17200336 (2), 12824892 (2), 15375499 (2), 11955671 (1) (see all 8)
carcinoma squamous cell	43.2	41	11778487 (3), 10435155 (2), 7554077 (2), 10793329 (2) (see all 30)

Genetic Association Database (GAD): CYP1A1
Human Genome Epidemiology (HuGE) Navigator: CYP1A1 (699 documents)

Export disorders for CYP1A1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CYP1A1 gene, integrated from 9 sources (see all 1831):
(articles sorted by number of sources associating them with CYP1A1)

Utopia: connect your pdf to the dynamic
world of online information

Variation in induced CYP1A1 levels: relationship to CYP1A1, Ah receptor and GSTM1 polymorphisms. (PubMed id 10739168)^{1, 2, 9} Smart J. and Daly A.K. (2000)
[Relationship between CYP1A1, GSTM1 genetic polymorphisms and susceptibility to esophageal squamous cell carcinoma] (PubMed id 11860825)^{1, 4, 9} Shao G....Wen B. (2000)
Genetic polymorphisms and transcriptional pattern analysis of CYP1A1, AhR, GSTM1, GSTP1 and GSTT1 genes in breast cancer. (PubMed id 11408954)^{1, 4, 9} Dialyna I.A....Spandidos D.A. (2001)
Ah receptor, CYP1A1, CYP1A2 and CYP1B1 gene polymorphisms are not involved in the risk of recurrent pregnancy loss. (PubMed id 15299091)^{1, 4, 9} Saijo Y....Kishi R. (2004)
[Association between gene mutation of cytochrome P450 1A1 in exon 7 A4889G locus and susceptibility to endometriosis] (PubMed id 12903034)^{1, 4, 9} Peng D.X....Lin J.M. (2003)
Toward the evaluation of function in genetic variability: characterizing human SNP frequencies and establishing BAC-transgenic mice carrying the human CYP1A1_CYP1A2 locus. (PubMed id 15643613)^{1, 2, 9} Jiang Z.... Nebert D.W. (2005)
Effects of dietary intake and genetic factors on hypermethylation of the hMLH1 gene promoter in gastric cancer. (PubMed id 15991278)^{1, 4, 9} Nan H.M....Kim H. (2005)
CYP1A1 and CYP1B1 genotypes, haplotypes, and TCDD-induced gene expression in subjects from Seveso, Italy. (PubMed id 15596250)^{1, 4, 9} Landi M.T....Bell D.A. (2005)
An investigation of mammographic density and gene variants in healthy women. (PubMed id 15382051)^{1, 4, 9} Maskarinec G....Le Marchand L. (2004)
[Allelic distribution of the CYP1A1 in lung cancer patients, middle-aged tissue donors and in elderly people without cancer] (PubMed id 15176217)^{1, 4, 9} Belogubova E.V....Imianitov E.N. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 1543	HGNC: 2595	AceView: CYP1A1	Ensembl:ENSG00000140465	euGenes: HUgn1543
ECgene: CYP1A1	Kegg: 1543	H-InvDB: CYP1A1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CYP1A1	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for CYP1A1	Genetics and Cytogenetics in Oncology and Haematology
Cytochrome P450 Allele Nomenclature Committee	http://www.cypalleles.ki.se/cyp1a1.htm
SHMPD	http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=CYP1A1
Wikipedia	http://en.wikipedia.org/wiki/CYP1A1

Intellectual Property for CYP1A1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for CYP1A1 gene:
Search GeneIP for patents involving CYP1A1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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CYP1A1 Gene

cytochrome P450, family 1, subfamily A, polypeptide 1

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CYP1A1 (Gene Symbol)
Cytochrome P450, Family 1, Subfamily A, Polypeptide 1
CYP1
CP11
P1-450
P450-C
P450DX
Cytochrome P450, Subfamily I (Aromatic Compound-Inducible), Polypeptide 1
Cytochrome P450 Form 6
Cytochrome P450-C
Cytochrome P450-P1
CYPIA1
EC 1.14.14.1
AHH
AHRR
Aryl Hydrocarbon Hydroxylase
Cytochrome P1-450, Dioxin-Inducible
Cytochrome P450 1A1
Flavoprotein-Linked Monooxygenase
Xenobiotic Monooxygenase

Lymphoblastic Leukemia Acute Childhood
Pregnancy loss
preterm delivery
LUNG TUMOR
Infertility
Genetic Susceptibility
environmental carcinogenesis
Endometriosis
BASAL CELL CARCINOMA, MULTIPLE
Carcinoma Basal Cell
Xeroderma Pigmentosum
Polyps
ADENOCARCINOMA LUNG
COLON CARCINOMA
LUNG CARCINOMA
Liver diseases
Atherosclerosis
Breast Cancer
Metaplasia
primary tumor
NSCLC
Adenocarcinoma
Neck Cancer
cell damage
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premalignant
Colorectal Carcinoma
Poisoning
Lymphoma
Miscarriage
Leukoplakia
mammary tumor
Shock
Precancerous lesions
Colorectal Cancer
HNSCC
Inflammation
Germ-Line Mutation
TUMOR LIVER
adult brain tumor
chemical carcinogenesis
Oral Cancer
Cervical Cancer
Pulmonary Disease Chronic Obstructive
prostate cancer
Pneumonia
Tumors
Cardiovascular Diseases
Metastasis
Lymphoblastic Leukemia Acute
Necrosis
Carcinoma Bronchogenic
SMOKING HABIT
Hepatitis C
Chronic Disease
Gastric Cancer
Barrett Esophagus
Cirrhosis
BREAST CARCINOMA
Melanoma
Colon Cancer
bladder cancer
Parkinson Disease
ESOPHAGEAL CARCINOMA
Glioma
Carcinoma
Leukemia
Osteoporosis
Laryngeal Cancer
HEPATOCELLULAR CARCINOMA
Calcification
AHH INDUCIBILITY
laryngeal squamous cell carcinoma
Carcinoma Renal Cell
AML adult
chemically induced
Cancer Lung
small cell lung cancer
Coronary Artery Disease
Wasting Syndrome
Skin Cancer
NASOPHARYNGEAL CARCINOMA
Adenoma
benign prostatic hyperplasia
OVARIAN CARCINOMA
Carcinoma Squamous Cell
Chromosomal Aberrations
chronic liver disease
Lymphoma Non-Hodgkins
leukemogenesis
Breast Diseases
Endometrial Cancer
Lupus Erythematosus Systemic

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CYP1A1 Gene

cytochrome P450, family 1, subfamily A, polypeptide 1

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for CYP1A1 gene

Pathways & Interactions
for CYP1A1 gene

Drugs & Compounds
for CYP1A1 gene

Transcripts
for CYP1A1 gene

Expression
for CYP1A1 gene

Orthologs
for CYP1A1 gene

Paralogs
for CYP1A1 gene

Genomic Variants
for CYP1A1 gene

Disorders / Diseases
for CYP1A1 gene

Publications
for CYP1A1 gene

Intellectual Property
for CYP1A1 gene

Products
for CYP1A1 gene