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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CYP1A1 Gene

protein-coding   GIFtS: 71
GCID: GC15M075011

cytochrome P450, family 1, subfamily A, polypeptide 1

(Previous names: cytochrome P450, subfamily I (aromatic compound-inducible),...)
(Previous symbol: CYP1)
 Explore 185 diseases affiliated with
CYP1A1 via
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 Human Malady Compendium 
Biological research products
for CYP1A1    

Aliases
for CYP1A1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Cytochrome P450, Family 1, Subfamily A, Polypeptide 11 2     CYPIA12 3
CYP11 2 5     EC 1.14.14.13 8
CP111 2     AHH2
P1-4501 2     AHRR2
P450-C1 2     Aryl Hydrocarbon Hydroxylase2
P450DX1 2     Cytochrome P1-450, Dioxin-Inducible2
Cytochrome P450, Subfamily I (Aromatic Compound-Inducible), Polypeptide 11 2     Cytochrome P450 1A12
Cytochrome P450 Form 62 3     Flavoprotein-Linked Monooxygenase2
Cytochrome P450-C2 3     Xenobiotic Monooxygenase2
Cytochrome P450-P12 3     

External Ids:    HGNC: 25951   Entrez Gene: 15432   Ensembl: ENSG000001404657   OMIM: 1083305   UniProtKB: P047983   

Export aliases for CYP1A1 gene to outside databases

Previous GC identifers: GC15M068848 GC15M068126 GC15M072587 GC15M072727 GC15M072798 GC15M051809


Summaries
for CYP1A1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CYP1A1:
This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are
monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and
other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic
aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is
unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with
lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15.
(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CP1A1_HUMAN, P04798
Function: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in
an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including
steroids, fatty acids, and xenobiotics

Gene Wiki entry for CYP1A1 (Cytochrome P450, family 1, member A1)


Genomic Views
for CYP1A1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NC_018926.1  NT_010194.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CYP1A1 gene promoter:
         GR   C/EBPbeta   p53   SREBP-1c   Bach2   SREBP-1b   HNF-4alpha1   MZF-1   SREBP-1a   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): CYP1A1 promoter sequence
   Search SABiosciences Chromatin IP Primers for CYP1A1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CYP1A1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q24.1   Ensembl cytogenetic band:  15q24.1   HGNC cytogenetic band: 15q24.1

CYP1A1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CYP1A1 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M075011:  view genomic region     (about GC identifiers)

Start:
 75,011,883 bp from pter      End:
 75,017,951 bp from pter
Size:
 6,069 bases      Orientation:
 minus strand

Proteins
for CYP1A1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CP1A1_HUMAN, P04798 (See protein sequence)
Recommended Name: Cytochrome P450 1A1  
Size: 512 amino acids; 58165 Da
Cofactor: Heme group (By similarity)
Subcellular location: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral
membrane protein
Secondary accessions: Q53G18

Explore the universe of human proteins at neXtProt for CYP1A1: NX_P04798

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P04798

    • 4/25 DME Specific Peptides for CYP1A1 (P04798) (see all 25)
     FSIASDP  PILRYLP  NQWQINH  ELDTVIG 

    CYP1A1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_000490.1  
    ENSEMBL proteins: 
     ENSP00000369050   ENSP00000456585   ENSP00000378489   ENSP00000455340   ENSP00000457668  
     ENSP00000455051   ENSP00000455846   ENSP00000378488  
    Reactome Protein details: P04798
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: CYP1A1
    OriGene Protein Over-expression Lysate: CYP1A1
    OriGene Custom Protein Services for CYP1A1 
    GenScript Custom Purified and Recombinant Proteins Services for CYP1A1
    Novus Biologicals CYP1A1 Protein
    Novus Biologicals CYP1A1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for CYP1A1

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005739mitochondrion IEA--
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0005792microsome ----


    CYP1A1 for ontologies           About GeneDecksing



    CYP1A1 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of CYP1A1
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    Novus Biologicals CYP1A1 Antibodies
    Abcam antibodies for CYP1A1 
    Uscn Antibodies for CYP1A1
    ThermoFisher Antibody for CYP1A1

    Assay Products for CYP1A1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CYP1A1
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for CYP1A1

    Protein Domains /
    Families
    for CYP1A1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CYP1A1 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR001128 Cyt_P450
     IPR017972 Cyt_P450_CS
     IPR002401 Cyt_P450_E_grp-I
     IPR008066 Cyt_P450_E_grp-I_CYP1

    Graphical View of Domain Structure for InterPro Entry P04798

    ProtoNet protein and cluster: P04798

    2 Blocks protein families:
    IPB002401 E-class P450 group I signature
    IPB008066 CYP1A P450 family signature


    UniProtKB/Swiss-Prot: CP1A1_HUMAN, P04798
    Similarity: Belongs to the cytochrome P450 family


    Function
    for CYP1A1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CP1A1_HUMAN, P04798
    Function: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in
    an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including
    steroids, fatty acids, and xenobiotics
    Catalytic activity: RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O
    Induction: By 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)

         Genatlas biochemistry entry for CYP1A1:
    cytochrome p450,family I (polycytic aromatic compound-inducible),member A1 (see CYP1@),associated with susceptibility
    to lung squamous cell carcinoma and to childhood acute lymphoblastic leukemia (in association with deletion of GSTM1)

    Enzyme Number (IUBMB): EC 1.14.14.11 2

    miRNA
    Products:            		 OriGene 3'-UTR Clone: CYP1A1
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CYP1A1
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate CYP1A1
    SwitchGear 3'UTR luciferase reporter plasmid: CYP1A1 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CYP1A1 (see all 7)
    OriGene shRNA RFP: CYP1A1
    OriGene siRNA: CYP1A1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CYP1A1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for CYP1A1

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CYP1A1 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CYP1A1 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: CYP1A1 (NM_000499)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CYP1A1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CYP1A1 

    Cell Line
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    Search LifeMap BioReagents cell lines for CYP1A1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYP1A1

    Gene Ontology (GO): 5/16 molecular function terms (GO ID links to tree view) (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004497monooxygenase activity ----
    GO:0005506iron ion binding IEA--
    GO:0005515protein binding ----
    GO:0008395steroid hydroxylase activity IEA--


    CYP1A1 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-outs for CYP1A1: Cyp1a1tm1.1Dwn Cyp1a2/Cyp1a1Cyp1a2/tm2Dwn Cyp1a2/Cyp1a1Cyp1a2/tm1.1Bra
         9 MGI mutant phenotypes (inferred from 7 alleles) (MGI details for Cyp1a1):
     cardiovascular system  growth/size  hematopoietic system  homeostasis/metabolism  immune system 
     liver/biliary system  mortality/aging  no phenotypic analysis  normal 

    CYP1A1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for CYP1A1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/20 super-pathways (see all 20) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)
    		Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)1.00
    		Benzo[a]pyrene metabolism0.33
    		Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)0.55
    		Benzo[a]pyrene metabolism0.33
    		Warfarin Pathway, Pharmacokinetics0.45
    		Expression of CYP1A10.12
    		Amodiaquine Pathway, Pharmacokinetics0.38
    2Acetaminophen Pathway, Pharmacokinetics
    		Pathway_PA165986194 -need delete1.00
    		Acetaminophen metabolism0.43
    		Acetaminophen Pathway, Pharmacokinetics1.00
    		Acetaminophen metabolism0.43
    3Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
    		Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)1.00
    		Fatty acid, triacylglycerol, and ketone body metabolism0.52
    		PPARA Activates Gene Expression0.74
    4Cytochrome P450 - arranged by substrate type
    		Cytochrome P450 - arranged by substrate type1.00
    		cytochrome P4500.73
    		Phase 1 - Functionalization of compounds0.74
    5Metabolism
    		Metabolism1.00
    		Metabolism of lipids and lipoproteins0.34
    		Metabolic pathways0.38

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/7 EMD Millipore Pathways for CYP1A1 (see all 7)
        Androstenedione and testosterone biosynthesis and metabolism p.1
    Estradiol metabolism
    2-Naphthylamine and 2-Nitronaphtalene metabolism
    Retinol metabolism
    Naphthalene metabolism


    5/7 GeneGo (Thomson Reuters) Pathways for CYP1A1 (see all 7)
        Estradiol metabolism
    Retinol metabolism
    Naphthalene metabolism
    2-Naphthylamine and 2-Nitronaphtalene metabolism
    Benzo[a]pyrene metabolism

    5/8 BioSystems Pathways for CYP1A1 (see all 8) 
        cytochrome P450
    Estrogen metabolism
    Benzo(a)pyrene metabolism
    Tamoxifen metabolism
    Fatty Acid Omega Oxidation

    5/13        Reactome Pathways for CYP1A1 (see all 13)
        Cytochrome P450 - arranged by substrate type
    Xenobiotics
    Metabolism
    Arachidonic acid metabolism
    Fatty acid, triacylglycerol, and ketone body metabolism

    5/7 PharmGKB Pathways for CYP1A1 (see all 7)
        Acetaminophen Pathway, Pharmacokinetics
    Amodiaquine Pathway, Pharmacokinetics
    Erlotinib Pathway, Pharmacokinetics
    Estrogen Metabolism Pathway
    Gefitinib Pathway, Pharmacokinetics

    5         Kegg Pathways  (Kegg details for CYP1A1):
        Steroid hormone biosynthesis
    Tryptophan metabolism
    Retinol metabolism
    Metabolism of xenobiotics by cytochrome P450
    Metabolic pathways


    CYP1A1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CYP1A1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/90 Interacting proteins for CYP1A1 (P047983 ENSP000003690504) via UniProtKB, MINT, STRING, and/or I2D (see all 90)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CYB5AP001673, ENSP000003416254I2D: score=1 STRING: ENSP00000341625
    HSP90AA1P079003I2D: score=1 
    HSPA4P349323I2D: score=1 
    AKR1C1ENSP000003702544STRING: ENSP00000370254
    AKR1C3ENSP000003699274STRING: ENSP00000369927
    About this table

    Gene Ontology (GO): 5/45 biological process terms (GO ID links to tree view) (see all 45):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001666response to hypoxia IEA--
    GO:0001889liver development ----
    GO:0006778porphyrin-containing compound metabolic process IEA--
    GO:0006805xenobiotic metabolic process TAS--
    GO:0006950response to stress ----


    CYP1A1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CYP1A1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CYP1A1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CYP1A1

    10/54 HMDB Compounds for CYP1A1 (see all 54)    About this table
    CompoundSynonyms CAS #PubMed Ids
    Melatonin
    • 5-Methoxy-N-acetyltryptamine
    • Circadin
    • MT6
    • Melatol
    • Melatonin
    • Melatonin (synth.) standard-grade
    • Melatonin (synth.) ultra-pure
    • Melatonine
    • Melovine
    • N-(2-(5-Methoxyindol-3-yl)ethyl)acetamide
    • N-(2-(5-methoxy-1H-indol-3-yl)ethyl)acetamide
    • N-(2-(5-methoxyindol-3-yl)ethyl)-Acetamide
    • N-Acetyl-5-methoxytryptamine
    • N-[2-(5-Methoxy-1H-indol-3-yl)ethyl)acetamide
    • N-[2-(5-Methoxy-1H-indol-3-yl)ethyl]acetamide
    • N-[2-(5-Methoxyindol-3-yl)ethyl]acetamide
    • N-[2-(5-methoxy-1H-indol-3-yl)ethyl]-Acetamide
    • N-[2-(5-methoxyindol-3-yl)ethyl]-Acetamide
    • N-acetyl-5-methoxy-tryptamine
    • N-acetyl-5-methoxy-tryptamine Melatonine
    • Regulin
    • {N-[2-(5-methoxy-1H-indol-3-yl)ethyl]-} Acetamide
    • {N-[2-(5-methoxyindol-3-yl)ethyl]-} Acetamide
    (see top 1)    		73-31-419919601
    10-HETE
    • 10-hydroxyeicosa-all-cis-5,8,11,14-tetraenoate
    • 10-hydroxyeicosa-all-cis-5,8,11,14-tetraenoic acid
    (see top 1)    		167697-52-1--
    11,12,15-THETA
    • 11,12,15-Trihydroxyicosatrienoic acid
    • 11,12,15S-trihydroxy-5Z,8Z,13E-eicosatrienoic acid
    • 11,12,15-TriHETRE
    • 11,12,15-Trihydroxyicosatrienoate
    • 11,12,15S-trihydroxy-5Z,8Z,13E-eicosatrienoate
    (see top 1)    		----
    11,12-Epoxyeicosatrienoic acid
    • 10-(3-(2-octenyl)oxiranyl)-5,8-Decadienoic acid
    • 11,12-EET
    • 11,12-Oxido-5,8,14-eicosatrienoic acid
    • 11,12-Oxido-5,8,14-eicosatrienoate
    • 11,12-Epoxyeicosatrienoate
    • 11,12-epoxy-5,8,14-eicosatrienoic acid
    • 11,12-epoxy-5,8,14-eicosatrienoate
    • 11,12-Epoxy-(5Z,8Z,14Z)-eicosatrienoic acid
    • (5Z,8Z,14Z)-11,12-Epoxyicosa-5,8,14-trienoic acid
    • (5Z,8Z,14Z)-11,12-Epoxyicosa-5,8,14-trienoate
    • (5Z,8Z,14Z)-11,12-Epoxyeicosa-5,8,14-trienoic acid
    • (5Z,8Z,14Z)-11,12-Epoxyeicosa-5,8,14-trienoate
    • 10-(3-(2-octenyl)oxiranyl)-5,8-Decadienoate
    • 11,12-Epoxyeicosatrienoic acid
    • 11,12-Epoxy-(5Z,8Z,14Z)-eicosatrienoate
    (see top 1)    		81276-02-0--
    11,14,15-THETA
    • (5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoic acid
    • 11,14,15-Trihydroxyicosatrienoic acid
    • (5Z,8Z,12E)-11,14,15-Trihydroxyicosa-5,8,12-trienoic acid
    • 11,14,15-trihydroxy-5Z,8Z,12E-eicosatrienoic acid
    • (5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoate
    • 11,14,15-Trihydroxyicosatrienoate
    • (5Z,8Z,12E)-11,14,15-Trihydroxyicosa-5,8,12-trienoate
    • 11,14,15-trihydroxy-5Z,8Z,12E-eicosatrienoate
    (see top 1)    		----
    11H-14,15-EETA
    • 14,15-Ep-11-HETrE
    • 11-Hydroxy-14,15-epoxyeicosatrienoic acid
    • 11-hydroxy-14,15-epoxy-5Z,8Z,12E-eicosatrienoic acid
    • 11-Hydroxy-14,15-EETA
    • (5Z,8Z,12E)-14,15-Epoxy-11-hydroxyicosa-5,8,12-trienoic acid
    • (5Z,8Z,12E)-14,15-Epoxy-11-hydroxyeicosa-5,8,12-trienoic acid
    • 11-Hydroxy-14,15-epoxyeicosatrienoate
    • 11-hydroxy-14,15-epoxy-5Z,8Z,12E-eicosatrienoate
    • (5Z,8Z,12E)-14,15-Epoxy-11-hydroxyicosa-5,8,12-trienoate
    • (5Z,8Z,12E)-14,15-Epoxy-11-hydroxyeicosa-5,8,12-trienoate
    • 14(15)-EpETrE
    (see top 1)    		219535-29-2--
    11beta-Hydroxytestosterone11beta,17beta-dihydroxyandrost-4-en-3-one 1816-85-9--
    12,13-EpOME
    • Vernolic acid
    • 12(13)-EpOME
    • (9Z)-12,13-epoxyoctadecenoic acid
    • (+/-)-12(13)-epoxy-9Z-octadecenoic acid
    • (9Z)-11-(3-pentyloxiran-2-yl)undec-9-enoic acid
    • (9Z)-12,13-epoxyoctadecenoate
    • (+/-)-12(13)-epoxy-9Z-octadecenoate
    • (9Z)-11-(3-pentyloxiran-2-yl)undec-9-enoate
    • 12,13-epoxyoctadec-9(Z)-enoate
    • 12,13-epoxy-9(Z)-octadecenoic acid
    • 12,13-epoxyoctadec-9(Z)-enoic acid
    • 12,13-epoxy-9(Z)-octadecenoate
    (see top 1)    		----
    13-HETE
    • 13-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoate
    • 13-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoic acid
    (see top 1)    		151910-72-4--
    14,15-Epoxy-5,8,11-eicosatrienoic acid
    • (5Z,8Z,11Z)-14,15-Epoxyicosa-5.8.11-trienoic acid
    • (+/-)14,15-EpETrE
    • 14(15)-EpETrE-EA
    • (5Z,8Z,11Z)-14,15-Epoxyeicosa-5.8.11-trienoic acid
    • 14,15-epoxy-5Z,8Z,11Z-eicosatrienoic acid
    • 14,15-EET
    • (5Z,8Z,11Z)-14,15-Epoxyicosa-5.8.11-trienoate
    • (5Z,8Z,11Z)-14,15-Epoxyeicosa-5.8.11-trienoate
    • 14,15-epoxy-5Z,8Z,11Z-eicosatrienoate
    • 14(15)-EpETrE
    • 14,15-EpETrE
    (see top 1)    		81276-03-1--

    10/83 DrugBank Compounds for CYP1A1 (see all 83)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Erlotinib-- 183321-74-6enzymesubstrate17575239 16166415 19733976
    MelatoninMEL (see all 4)73-31-4enzymesubstrate inhibitor19919601 15616152 19934256
    TamoxifenTamoxifen Citrate (see all 5)10540-29-1enzymesubstrate12124303 19934256 19515014
    AmiodaroneAmiodarona [INN-Spanish] (see all 5)1951-25-3enzymesubstrate18445370 19934256
    AmlodipineAmlodipine Benzenesulfonate (see all 6)88150-42-9enzymeinhibitor10805063 19934256
    ChlorzoxazoneChloroxazone (see all 3)95-25-0enzymesubstrate15231049 20164110
    Cinnarizine-- 298-57-7enzymesubstrate19934256 19515014
    Dasatinib-- 302962-49-8enzymesubstrate18556438 19733976
    Flunarizine(E)-1-[Bis-(p-fluorophenyl)methyl]-4-cinnamylpiperazine (see all 6)52468-60-7enzymesubstrate19934256 19515014
    FluvastatinFluindostatin (see all 5)93957-54-1enzymesubstrate19934256 19515014

    10/140 Novoseek chemical compound relationships for CYP1A1 gene (see all 140)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tcdd 94 698 8396892 (9), 15630080 (7), 11728381 (6), 9931287 (6) (see all 99)
    ethoxyresorufin 91.1 84 17959138 (4), 8093105 (3), 11599655 (2), 8396892 (1) (see all 67)
    benzo(a)pyrene 89.7 376 18372000 (6), 19330882 (6), 16280210 (6), 10503953 (6) (see all 99)
    alpha-naphthoflavone 88.1 64 1329656 (4), 12628305 (2), 2115161 (2), 1315629 (1) (see all 38)
    3-methylcholanthrene 86.4 193 12941938 (7), 16137816 (4), 17276403 (3), 9465551 (3) (see all 64)
    hydrocarbons 85.2 131 8954573 (2), 17630984 (2), 19362136 (2), 8353849 (2) (see all 99)
    mspi 84.8 71 1284589 (4), 8706015 (3), 8877059 (3), 8983277 (2) (see all 51)
    beta-naphthoflavone 82.9 79 11076701 (3), 12147246 (3), 18502397 (3), 19470599 (3) (see all 36)
    4-methoxyestradiol 79.6 1 10403516 (1)
    benz(a)anthracene 78.8 30 1700499 (4), 8920757 (2), 1358564 (2), 1654865 (2) (see all 14)

    Search CenterWatch for drugs/clinical trials and news about CYP1A1 / CP1A1 

    Transcripts
    for CYP1A1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CYP1A1 gene: 
    NM_000499.3  

    Unigene Cluster for CYP1A1:

    Cytochrome P450, family 1, subfamily A, polypeptide 1
    Hs.72912  [show with all ESTs]
    Unigene Representative Sequence: NM_000499
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000379727(uc002ayq.4 uc010bjy.3) ENST00000567032 ENST00000395049
    ENST00000562201 ENST00000564596(uc010bjz.1) ENST00000569630 ENST00000566503
    ENST00000395048(uc002ayp.4 uc010bju.3 uc010bjv.3 uc010bjw.3 uc010bjx.3)


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    Inhib. RNA
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    OriGene shRNA RFP: CYP1A1
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    Clone
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    Additional cDNA sequence: 

    AK223108.1 AK223113.1 AK310810.1 AK313880.1 AM233517.1 AM233518.1 AM233519.1 AM233520.1 
    AM236046.1 AM236047.1 AY310359.1 AY871801.1 BC023019.1 K03191.1 M12079.1 

    2 DOTS entries:

    DT.310017  DT.100744671 

    24/52 AceView cDNA sequences (see all 52):

    BC023019 AV656441 AW451941 BQ005861 AI417887 AW949660 AL600919 AL600881 
    AL600770 NM_000499 BQ878741 BU620769 CA423835 BI254564 AI745534 CB267342 
    BP353358 CB265483 AW291515 M12079 BU182605 AH007293 AL598658 BF593495 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for CYP1A1    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
    SP1:                                                
    SP2:                                                


    ECgene alternative splicing isoforms for CYP1A1

    Expression
    for CYP1A1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CYP1A1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CTTGCATAAG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    CYP1A1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LiverLiver LobulePerivenous HepatocytesLiver
    AdiposeInterscapular Brown Adipose DepotAdipose
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 5 LifeMap Cells 
    NameCategory
    PureStem™ endothelial progenitor 30-MV2-12 (Embryonic Progenitor Cell)Blood, Endothelium
    PureStem™ endothelial Progenitor 30-SM2-3 (Embryonic Progenitor Cell)Blood, Endothelium
    PureStem™ endothelial progenitor 30-MV2-14 (Embryonic Progenitor Cell)Endothelium
    Syncytiotrophoblast-like cells (Generation of syncyt...)
    HyStem+BMP4-induced 7SMOO32 cells (HyStem+BMP4 inductio...)Adipose

    See CYP1A1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CYP1A1

    SOURCE GeneReport for Unigene cluster: Hs.72912

    UniProtKB/Swiss-Prot: CP1A1_HUMAN, P04798
    Tissue specificity: Lung, lymphocytes and placenta

        SABiosciences Expression via Pathway-Focused PCR Arrays including CYP1A1 (see all 6): 
              Estrogen Receptor Signaling in human mouse rat
              Cancer Drug Resistance in human mouse rat
              Drug Metabolism: Phase I Enzymes in human mouse rat
              Cellular Stress Responses in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

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    In Situ
    Assay Products:     
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    Orthologs
    for CYP1A1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CYP1A1 gene from 7/22 species (see all 22)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves CYP1A11 cytochrome P450, family 1, subfamily A, polypeptide more 67.06(n)
    62.4(a)    		   396051  NM_205146.1  NP_990477.1 
    lizard
    (Anolis carolinensis)    		 Reptilia --
    --
    (see all 3)    		 --
    		 59(a)
    58(a)
    (see all 3)    		 many ↔ many
    many ↔ many
    (see all 3)    		 GL343721.1(52577-61909)
    GL343721.1(108864-116106)
    African clawed frog
    (Xenopus laevis)    		 Amphibia AB022087.12   -- 71.3(n)    AB022087.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii cyp1a12 cytochrome P450, subfamily I, polypeptide 1 74.16(n)   140634  AB078927.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Cyp18a13 steroid biosynthesis cytochrome P450 32(a)
    (best of 2)    		   17D1   --
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons CYP93D11 cytochrome P450, family 93, subfamily D, polypeptide more 41.25(n)
    28.29(a)    		   830580  NM_120772.1  NP_196307.1 
    rice
    (Oryza sativa)    		 Liliopsida Os06g06136001 hypothetical protein 46.09(n)
    32.35(a)    		   4341526  NM_001064607.1  NP_001058072.1 


    ENSEMBL Gene Tree for CYP1A1 (if available)
    TreeFam Gene Tree for CYP1A1 (if available) 

    Paralogs
    for CYP1A1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CYP1A1 gene
    CYP1B12  CYP1A22  CYP17A12  CYP2G1P2  ENSG000001982512  CYP21A22  
    18/30 SIMAP similar genes for CYP1A1 using alignment to 10 protein entries:     CP1A1_HUMAN (see all proteins) (see all similar genes):
    CYP1A2    CYP1B1    CYP2U1    CYP4V2    DKFZp686I24235    CYP2D6
    CYP21A2    CYP2A7    CYP2A13    CYP2A6    CYP2C9    CYP2S1
    CYP2C8    CYP2R1    CYP2B7    CYP2F1    CYP2J2    CYP2A6V2

    CYP1A1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CYP1A1
    PGOHUM00000236640


    Genomic Variants
    for CYP1A1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/213 NCBI SNPs in CYP1A1 are shown (see all 213)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 15 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1494232661,2
    		--75011415(+) AGGGCA/GTAAGT 1 -- ds50010--------
    rs456271341,2
    		C,--75011591(-) CGCAGG/CCACAC 1 -- ds50015Minor allele frequency- C:0.01NS 176
    rs798120151,2
    		F--75011640(+) GAGCCT/CGGAGG 1 -- ds50011Minor allele frequency- C:0.39PA 802
    rs46469031,2
    		C,F,A,H,--75011641(-) CCTCCA/C/TGGGCT 1 -- ds500117NA MN NS WA CSA EA 934
    rs1397748601,2
    		--75011779(+) TGCTAC/TCTCCT 1 -- ds50010--------
    rs1889132831,2
    		--75011843(+) TTAGAC/GGAGTG 1 -- ds50010--------
    rs1817168151,2
    		--75011844(+) TAGACA/GAGTGA 1 -- ds50010--------
    rs24723071,2
    		C,H--75011855(+) TGAATC/TATTTA 1 -- ds500111Minor allele frequency- T:0.00NS EA NA MN 812
    rs1853831341,2
    		--75011974(+) ATTAAA/CTCAAT 1 -- ut310--------
    rs178610841,2
    		C,F,--75012019(+) ATGCAG/TGCTAG 1 -- ut3111Minor allele frequency- T:0.06MN NS WA 714

    HapMap Linkage Disequilibrium report for CYP1A1 (75011883 - 75017951 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for CYP1A1
         1 CNV: 9749
         1 Inversion: 37170
    Human Gene Mutation Database (HGMD): CYP1A1

    Locus Specific Mutation Databases (LSDB): CYP1A1

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CYP1A1
    DNA2.0 Custom Variant and Variant Library Synthesis for CYP1A1

    Disorders / Diseases
    for CYP1A1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CYP1A1 for disorders           About GeneDecksing

    OMIM gene information: 108330    OMIM disorders: --

    20/185 diseases for CYP1A1 (see all 185):    About MalaCards
    lung cancer    porphyria cutanea tarda    diffuse large b-cell lymphoma    sudden infant death syndrome
    age related macular degeneration    hidradenitis suppurativa    xeroderma pigmentosum    patent ductus arteriosus
    squamous cell carcinoma    non-small cell lung carcinoma    basal cell carcinoma, multiple    b-cell lymphomas
    barrett's esophagus    laryngeal squamous cell carcinoma    pre-eclampsia    basal cell carcinoma
    testicular germ cell tumor    malignant pleural mesothelioma    cholesterol    intrahepatic cholestasis

    4 diseases from the University of Copenhagen DISEASES database for CYP1A1:
    Lung cancer     Hepatocellular carcinoma     Breast cancer     Carcinoma

    10/93 Novoseek disease relationships for CYP1A1 gene (see all 93)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ahh inducibility 87.7 42 8126925 (5), 8609043 (5), 9465551 (5), 9731718 (4) (see all 10)
    cancer lung 68.2 293 9894148 (6), 11778487 (6), 16228113 (6), 10491856 (5) (see all 99)
    genetic susceptibility 61.7 23 18304461 (2), 10698723 (1), 19472123 (1), 20054510 (1) (see all 18)
    chemical carcinogenesis 58 6 12628305 (1), 19573549 (1), 12520071 (1), 11370663 (1) (see all 6)
    cancer 57.9 119 8552885 (3), 15355884 (3), 15805301 (2), 16402077 (2) (see all 91)
    breast cancer 57.1 155 9485019 (6), 20088394 (5), 11408954 (5), 16807674 (4) (see all 79)
    environmental carcinogenesis 56.6 1 18463401 (1)
    oral cancer 46 35 19469619 (5), 17461521 (4), 19160101 (3), 9332761 (3) (see all 10)
    adenocarcinoma lung 43.3 14 17200336 (2), 12824892 (2), 15375499 (2), 11955671 (1) (see all 8)
    carcinoma squamous cell 43.2 41 11778487 (3), 10435155 (2), 7554077 (2), 10793329 (2) (see all 30)

    Genetic Association Database (GAD): CYP1A1
    Human Genome Epidemiology (HuGE) Navigator: CYP1A1 (699 documents)

    Export disorders for CYP1A1 gene to outside databases

    Publications
    for CYP1A1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CYP1A1 gene, integrated from 9 sources (see all 1831):
    (articles sorted by number of sources associating them with CYP1A1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Variation in induced CYP1A1 levels: relationship to CYP1A1, Ah receptor and GSTM1 polymorphisms. (PubMed id 10739168)1, 2, 9 Smart J. and Daly A.K. (2000)
    2. [Relationship between CYP1A1, GSTM1 genetic polymorphisms and susceptibility to esophageal squamous cell carcinoma] (PubMed id 11860825)1, 4, 9 Shao G....Wen B. (2000)
    3. Genetic polymorphisms and transcriptional pattern analysis of CYP1A1, AhR, GSTM1, GSTP1 and GSTT1 genes in breast cancer. (PubMed id 11408954)1, 4, 9 Dialyna I.A....Spandidos D.A. (2001)
    4. Ah receptor, CYP1A1, CYP1A2 and CYP1B1 gene polymorphisms are not involved in the risk of recurrent pregnancy loss. (PubMed id 15299091)1, 4, 9 Saijo Y....Kishi R. (2004)
    5. [Association between gene mutation of cytochrome P450 1A1 in exon 7 A4889G locus and susceptibility to endometriosis] (PubMed id 12903034)1, 4, 9 Peng D.X....Lin J.M. (2003)
    6. Toward the evaluation of function in genetic variability: characterizing human SNP frequencies and establishing BAC-transgenic mice carrying the human CYP1A1_CYP1A2 locus. (PubMed id 15643613)1, 2, 9 Jiang Z.... Nebert D.W. (2005)
    7. Effects of dietary intake and genetic factors on hypermethylation of the hMLH1 gene promoter in gastric cancer. (PubMed id 15991278)1, 4, 9 Nan H.M....Kim H. (2005)
    8. CYP1A1 and CYP1B1 genotypes, haplotypes, and TCDD-induced gene expression in subjects from Seveso, Italy. (PubMed id 15596250)1, 4, 9 Landi M.T....Bell D.A. (2005)
    9. An investigation of mammographic density and gene variants in healthy women. (PubMed id 15382051)1, 4, 9 Maskarinec G....Le Marchand L. (2004)
    10. [Allelic distribution of the CYP1A1 in lung cancer patients, middle-aged tissue donors and in elderly people without cancer] (PubMed id 15176217)1, 4, 9 Belogubova E.V....Imianitov E.N. (2004)

    External Searches for CYP1A1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CYP1A1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1543 HGNC: 2595 AceView: CYP1A1 Ensembl:ENSG00000140465 euGenes: HUgn1543
    ECgene: CYP1A1 Kegg: 1543 H-InvDB: CYP1A1

    Other Databases showing CYP1A1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CYP1A1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CYP1A1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CYP1A1 Genetics and Cytogenetics in Oncology and Haematology
    Cytochrome P450 Allele Nomenclature Committeehttp://www.cypalleles.ki.se/cyp1a1.htm
    SHMPDhttp://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=CYP1A1
    Wikipedia http://en.wikipedia.org/wiki/CYP1A1

    Intellectual Property
    for CYP1A1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CYP1A1 gene:
    Search GeneIP for patents involving CYP1A1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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