Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CYP1A1 Gene

Aliases for CYP1A1 Gene

  • Cytochrome P450 Family 1 Subfamily A Member 1 2 3 5
  • Cytochrome P450, Subfamily I (Aromatic Compound-Inducible), Polypeptide 1 2 3
  • Cytochrome P450, Family 1, Subfamily A, Polypeptide 1 2 3
  • Cytochrome P450 Form 6 3 4
  • Cytochrome P450-P1 3 4
  • Cytochrome P450-C 3 4
  • EC 1.14.14.1 4 61
  • CYPIA1 3 4
  • Cytochrome P1-450, Dioxin-Inducible 3
  • Flavoprotein-Linked Monooxygenase 3
  • Aryl Hydrocarbon Hydroxylase 3
  • Xenobiotic Monooxygenase 3
  • Cytochrome P450 1A1 3
  • P1-450 3
  • P450-C 3
  • P450DX 3
  • AhRR 3
  • CP11 3
  • CYP1 3
  • AHH 3

External Ids for CYP1A1 Gene

Previous HGNC Symbols for CYP1A1 Gene

  • CYP1

Previous GeneCards Identifiers for CYP1A1 Gene

  • GC15M068848
  • GC15M068126
  • GC15M072587
  • GC15M072727
  • GC15M072798
  • GC15M075011
  • GC15M051809

Summaries for CYP1A1 Gene

Entrez Gene Summary for CYP1A1 Gene

  • This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2016]

GeneCards Summary for CYP1A1 Gene

CYP1A1 (Cytochrome P450 Family 1 Subfamily A Member 1) is a Protein Coding gene. Diseases associated with CYP1A1 include Lung Squamous Cell Carcinoma and Ehrlich Tumor Carcinoma. Among its related pathways are Metabolism of xenobiotics by cytochrome P450 and Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha). GO annotations related to this gene include enzyme binding and iron ion binding. An important paralog of this gene is CYP1A2.

UniProtKB/Swiss-Prot for CYP1A1 Gene

  • Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Gene Wiki entry for CYP1A1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYP1A1 Gene

Genomics for CYP1A1 Gene

Regulatory Elements for CYP1A1 Gene

Enhancers for CYP1A1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around CYP1A1 on UCSC Golden Path with GeneCards custom track

Promoters for CYP1A1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for CYP1A1 Gene

Chromosome:
15
Start:
74,719,542 bp from pter
End:
74,725,610 bp from pter
Size:
6,069 bases
Orientation:
Minus strand

Genomic View for CYP1A1 Gene

Genes around CYP1A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CYP1A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CYP1A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYP1A1 Gene

Proteins for CYP1A1 Gene

  • Protein details for CYP1A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P04798-CP1A1_HUMAN
    Recommended name:
    Cytochrome P450 1A1
    Protein Accession:
    P04798
    Secondary Accessions:
    • A4F3V9
    • A4F3W0
    • Q53G18

    Protein attributes for CYP1A1 Gene

    Size:
    512 amino acids
    Molecular mass:
    58165 Da
    Cofactor:
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CYP1A1 Gene

    Alternative splice isoforms for CYP1A1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CYP1A1 Gene

Post-translational modifications for CYP1A1 Gene

  • Glycosylation at Ser 67
  • Modification sites at PhosphoSitePlus

Domains & Families for CYP1A1 Gene

Gene Families for CYP1A1 Gene

Graphical View of Domain Structure for InterPro Entry

P04798

UniProtKB/Swiss-Prot:

CP1A1_HUMAN :
  • Belongs to the cytochrome P450 family.
Family:
  • Belongs to the cytochrome P450 family.
genes like me logo Genes that share domains with CYP1A1: view

Function for CYP1A1 Gene

Molecular function for CYP1A1 Gene

GENATLAS Biochemistry:
cytochrome p450,family I (polycytic aromatic compound-inducible),member A1 (see CYP1@),associated with susceptibility to lung squamous cell carcinoma and to childhood acute lymphoblastic leukemia (in association with deletion of GSTM1)
UniProtKB/Swiss-Prot CatalyticActivity:
RH + [reduced NADPH--hemoprotein reductase] + O(2) = ROH + [oxidized NADPH--hemoprotein reductase] + H(2)O.
UniProtKB/Swiss-Prot Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
UniProtKB/Swiss-Prot Induction:
By 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).

Enzyme Numbers (IUBMB) for CYP1A1 Gene

Gene Ontology (GO) - Molecular Function for CYP1A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity IEA --
GO:0004497 monooxygenase activity TAS --
GO:0005506 iron ion binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0008395 steroid hydroxylase activity IEA --
genes like me logo Genes that share ontologies with CYP1A1: view
genes like me logo Genes that share phenotypes with CYP1A1: view

Human Phenotype Ontology for CYP1A1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for CYP1A1 Gene

MGI Knock Outs for CYP1A1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for CYP1A1 Gene

Localization for CYP1A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYP1A1 Gene

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CYP1A1 Gene COMPARTMENTS Subcellular localization image for CYP1A1 gene
Compartment Confidence
endoplasmic reticulum 5
mitochondrion 3
nucleus 3
cytosol 2
extracellular 2
peroxisome 2
plasma membrane 2
cytoskeleton 1
vacuole 1

Gene Ontology (GO) - Cellular Components for CYP1A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IEA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0031090 organelle membrane IEA --
GO:0043231 intracellular membrane-bounded organelle IBA --
genes like me logo Genes that share ontologies with CYP1A1: view

Pathways & Interactions for CYP1A1 Gene

genes like me logo Genes that share pathways with CYP1A1: view

Gene Ontology (GO) - Biological Process for CYP1A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001666 response to hypoxia IEA --
GO:0001889 liver development IEA --
GO:0006778 porphyrin-containing compound metabolic process IEA --
GO:0007568 aging IEA --
GO:0008283 cell proliferation IEA --
genes like me logo Genes that share ontologies with CYP1A1: view

No data available for SIGNOR curated interactions for CYP1A1 Gene

Drugs & Compounds for CYP1A1 Gene

(185) Drugs for CYP1A1 Gene - From: DrugBank, PharmGKB, ApexBio, FDA Approved Drugs, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phenobarbital Approved Pharma Agonist, Enzyme, inducer 54
Chlorzoxazone Approved Pharma Agonist, Activator, Enzyme, substrate 6
Clofibrate Approved Pharma Agonist, Enzyme, inducer 2
Daunorubicin Approved Pharma Enzyme, substrate DNA topoisomerase II inhibitor 259
Dexamethasone Approved, Investigational, Vet_approved Pharma Agonist, Enzyme, inhibitor, inducer 2001

(101) Additional Compounds for CYP1A1 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
11,12,15-THETA
  • 11,12,15-TriHETRE
  • 11,12,15-Trihydroxyicosatrienoate
  • 11,12,15-Trihydroxyicosatrienoic acid
  • 11,12,15S-Trihydroxy-5Z,8Z,13E-eicosatrienoate
  • 11,12,15S-Trihydroxy-5Z,8Z,13E-eicosatrienoic acid
11,12-Epoxyeicosatrienoic acid
  • (5Z,8Z,14Z)-11,12-Epoxyeicosa-5,8,14-trienoate
  • (5Z,8Z,14Z)-11,12-Epoxyeicosa-5,8,14-trienoic acid
  • (5Z,8Z,14Z)-11,12-Epoxyicosa-5,8,14-trienoate
  • (5Z,8Z,14Z)-11,12-Epoxyicosa-5,8,14-trienoic acid
  • 10-(3-(2-Octenyl)oxiranyl)-5,8-Decadienoate
81276-02-0
11,14,15-THETA
  • (5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoate
  • (5Z,8Z,12E)-11,14,15-Trihydroxyeicosa-5,8,12-trienoic acid
  • (5Z,8Z,12E)-11,14,15-Trihydroxyicosa-5,8,12-trienoate
  • (5Z,8Z,12E)-11,14,15-Trihydroxyicosa-5,8,12-trienoic acid
  • 11,14,15-Trihydroxy-5Z,8Z,12E-eicosatrienoate
11H-14,15-EETA
  • (5Z,8Z,12E)-14,15-Epoxy-11-hydroxyeicosa-5,8,12-trienoate
  • (5Z,8Z,12E)-14,15-Epoxy-11-hydroxyeicosa-5,8,12-trienoic acid
  • (5Z,8Z,12E)-14,15-Epoxy-11-hydroxyicosa-5,8,12-trienoate
  • (5Z,8Z,12E)-14,15-Epoxy-11-hydroxyicosa-5,8,12-trienoic acid
  • 11-Hydroxy-14,15-EETA
219535-29-2
12,13-EpOME
  • (+/-)-12(13)-epoxy-9Z-octadecenoate
  • (+/-)-12(13)-epoxy-9Z-octadecenoic acid
  • (9Z)-11-(3-pentyloxiran-2-yl)undec-9-enoate
  • (9Z)-11-(3-pentyloxiran-2-yl)undec-9-enoic acid
  • (9Z)-12,13-epoxyoctadecenoate

(4) ApexBio Compounds for CYP1A1 Gene

Compound Action Cas Number
7-Ethoxyresorufin Specific subtrate of CYP1A 5725-91-7
Diosmetin CYP1A1 inhibitor 520-34-3
Methoxyresorufin 5725-89-3
Pentoxyresorufin 87687-03-4
genes like me logo Genes that share compounds with CYP1A1: view

Drug Products

Transcripts for CYP1A1 Gene

Unigene Clusters for CYP1A1 Gene

Cytochrome P450, family 1, subfamily A, polypeptide 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CYP1A1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
SP1:
SP2:

Relevant External Links for CYP1A1 Gene

GeneLoc Exon Structure for
CYP1A1
ECgene alternative splicing isoforms for
CYP1A1

Expression for CYP1A1 Gene

mRNA expression in normal human tissues for CYP1A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CYP1A1 Gene

This gene is overexpressed in Liver (x8.2), Lung (x5.5), Adipose - Subcutaneous (x5.0), and Skin - Sun Exposed (Lower leg) (x4.0).

Protein differential expression in normal tissues from HIPED for CYP1A1 Gene

This gene is overexpressed in Gallbladder (22.6), Liver (18.4), Plasma (12.0), Pancreatic juice (10.0), and Islet of Langerhans (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CYP1A1 Gene



Protein tissue co-expression partners for CYP1A1 Gene

NURSA nuclear receptor signaling pathways regulating expression of CYP1A1 Gene:

CYP1A1

SOURCE GeneReport for Unigene cluster for CYP1A1 Gene:

Hs.72912

mRNA Expression by UniProt/SwissProt for CYP1A1 Gene:

P04798-CP1A1_HUMAN
Tissue specificity: Lung, lymphocytes and placenta.
genes like me logo Genes that share expression patterns with CYP1A1: view

Primer Products

Orthologs for CYP1A1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CYP1A1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CYP1A1 34
  • 85.42 (n)
  • 81.18 (a)
CYP1A1 35
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CYP1A1 34
  • 84.65 (n)
  • 82.09 (a)
CYP1A1 35
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cyp1a1 34
  • 82.61 (n)
  • 80.39 (a)
Cyp1a1 16
Cyp1a1 35
  • 78 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LOC453744 34
  • 99.67 (n)
  • 99.8 (a)
CYP1A1 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cyp1a1 34
  • 82.42 (n)
  • 79.61 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 72 (a)
ManyToMany
-- 35
  • 59 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 70 (a)
OneToMany
chicken
(Gallus gallus)
Aves CYP1A1 34
  • 67.06 (n)
  • 62.4 (a)
CYP1A1 35
  • 60 (a)
ManyToMany
CYP1A4 35
  • 58 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 55 (a)
ManyToMany
-- 35
  • 58 (a)
ManyToMany
-- 35
  • 60 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia cyp1a1 34
  • 65.14 (n)
  • 63.22 (a)
Str.2144 34
zebrafish
(Danio rerio)
Actinopterygii cyp1a 34
  • 60.88 (n)
  • 57.88 (a)
cyp1a1 34
cyp1a 35
  • 55 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Cyp18a1 36
  • 32 (a)
Cyp307a1 36
  • 28 (a)
spo 35
  • 24 (a)
ManyToMany
spok 35
  • 22 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons CYP93D1 34
  • 40.54 (n)
  • 28.05 (a)
rice
(Oryza sativa)
Liliopsida Os06g0613600 34
  • 45.38 (n)
  • 31.3 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 31 (a)
ManyToMany
-- 35
  • 21 (a)
ManyToMany
Species where no ortholog for CYP1A1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CYP1A1 Gene

ENSEMBL:
Gene Tree for CYP1A1 (if available)
TreeFam:
Gene Tree for CYP1A1 (if available)

Paralogs for CYP1A1 Gene

Paralogs for CYP1A1 Gene

Pseudogenes.org Pseudogenes for CYP1A1 Gene

genes like me logo Genes that share paralogs with CYP1A1: view

Variants for CYP1A1 Gene

Sequence variations from dbSNP and Humsavar for CYP1A1 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1048943 - 74,720,644(-) AGACC(A/C/G/T)TTGCC reference, missense
rs1799814 - 74,720,646(-) TGAGA(A/C/T)CATTG reference, missense
rs34260157 - 74,721,708(-) ACATC(C/G/T)GGGAC reference, missense
rs56313657 - 74,721,463(+) AAATA(A/C/T)ATGAG reference, missense
rs72547509 - 74,720,685(+) AGATA(A/G/T)TCACC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for CYP1A1 Gene

Variant ID Type Subtype PubMed ID
esv2763106 CNV loss 21179565
esv3636907 CNV loss 21293372
nsv1121512 CNV deletion 24896259
nsv817698 CNV gain 17921354
nsv833055 CNV loss 17160897

Variation tolerance for CYP1A1 Gene

Residual Variation Intolerance Score: 96.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.23; 84.97% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CYP1A1 Gene

Human Gene Mutation Database (HGMD)
CYP1A1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CYP1A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CYP1A1 Gene

Disorders for CYP1A1 Gene

MalaCards: The human disease database

(26) MalaCards diseases for CYP1A1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
lung squamous cell carcinoma
  • epidermoid cell carcinoma of the lung
ehrlich tumor carcinoma
  • ehrlich's tumor
oral cavity cancer
  • malignant neoplasm of anterior portion of floor of mouth
oral cancer
  • malignant neoplasm of mouth
hepatocellular adenoma
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CYP1A1

Genetic Association Database (GAD)
CYP1A1
Human Genome Epidemiology (HuGE) Navigator
CYP1A1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CYP1A1
genes like me logo Genes that share disorders with CYP1A1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CYP1A1 Gene

Publications for CYP1A1 Gene

  1. Genetic association study of CYP1A1 polymorphisms identifies risk haplotypes in nonsmall cell lung cancer. (PMID: 19608585) Wright C.M. … Fong K.M. (Eur. Respir. J. 2010) 3 22 46 65
  2. Polymorphisms in genes of the steroid hormone biosynthesis and metabolism pathways and endometrial cancer risk. (PMID: 20381444) Ashton K.A. … Scott R.J. (Cancer Epidemiol 2010) 3 22 46 65
  3. Association of CYP1A1*2 polymorphisms with breast cancer risk: a case control study. (PMID: 19346634) Surekha D. … Vishnupriya S. (Indian J Med Sci 2009) 3 22 46 65
  4. [Relationship between CYP1A1 gene polymorphisms and urinary 1-hydroxypyrene levels in coke oven workers]. (PMID: 19538838) Nie J.S. … Niu Q. (Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2009) 3 22 46 65
  5. Evidence for increased cytochrome P450 1A1 expression in blood lymphocytes of lung cancer patients. (PMID: 19632247) Shah P.P. … Parmar D. (Mutat. Res. 2009) 3 22 46 65

Products for CYP1A1 Gene

Sources for CYP1A1 Gene

Content
Loading form....