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CYP19A1 Gene

protein-coding GIFtS: 64

GC15M051500

cytochrome P450, family 19, subfamily A, polypeptide 1
(Previous names: cytochrome P450, subfamily XIX (aromatization of androgens) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: CYP19)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases & Descriptions
cytochrome P450, family 19, subfamily A, polypeptide 1¹ ²		Estrogen synthase² ³
ARO1¹ ² ³		CYPXIX² ³
CYAR¹ ² ³		flavoprotein-linked monooxygenase²
ARO¹ ² ⁵		MGC104309²
CYP19² ³ ⁵		cytochrome P450 19A1²
cytochrome P450, subfamily XIX (aromatization of androgens)¹ ²		microsomal monooxygenase²
P-450AROM¹ ²		estrogen synthetase²
aromatase¹ ²		Aromatase³
CPV1¹ ²		EC 1.14.14.1³
Cytochrome P-450AROM² ³

External Ids:	HGNC: 2594¹	Entrez Gene: 1588²	Ensembl: ENSG00000137869⁷	UniProtKB: P11511³

Search outside databases for aliases for CYP19A1 gene

Previous GC identifers: GC15M044547 GC15M049080 GC15M049217 GC15M049288

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CYP19A1:

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are

monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and

other lipids. This protein localizes to the endoplasmic reticulum and catalyzes the last steps of estrogen

biosynthesis, three successive hydroxylations of the A ring of androgens. Mutations in this gene can result in either

increased or decreased aromatase activity; the associated phenotypes suggest that estrogen functions both as a sex

steroid hormone and in growth or differentiation. The gene expresses two transcript variants. (provided by RefSeq)

UniProtKB/Swiss-Prot: CP19A_HUMAN, P11511

Function: Catalyzes the formation of aromatic C18 estrogens from C19 androgens

summary for CYP19A1:

Cytochrome P450 (CYP450) enzymes are a diverse group of catalysts that contains 57 members in humans. CYPs

are usually membrane-bound and are localized to the inner mitochondrial or endoplasmic reticular membrane.

CYPs have oxygenase activity and commonly catalyze redox reactions, involving the oxidation of the substrate

and reduction of water. This group of enzymes contain a heme ion within the active site, which is essential

for catalytic activity. CYPs have been found in all organisms tested and are ubiquitously expressed. They

are found at high levels in the liver, where they have an important role in metabolism of drugs and

endogenous toxic compounds (for example bilirubin). Most CYPs can metabolize numerous substrates and this

accounts for their major role in drug interactions. CYPs also have functions in steroid hormone synthesis,

cholesterol synthesis and vitamin D metabolism.

Gene Wiki entry for CYP19A1 (Aromatase)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC and Ensembl (release 56), Regulatory elements and Epigenetics data according to SABiosciences)
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Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CYP19A1 gene upstream (promoter) region

:
NF-kappaB1 C/EBPbeta C/EBPalpha GR-alpha GR-beta YY1 GATA-2 PPAR-gamma2 PPAR-gamma1 Egr-1

Epigenetics:

SABiosciences Methyl-Profiler DNA Methylation qPCR Primer Assays for CYP19A1:

MePH19227-2A

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q21.1 Ensembl cytogenetic band: 15q21.2 HGNC cytogenetic band: 15q21

CYP19A1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 15 GeneLoc Exon Structure

GeneLoc location for GC15M051500: view genomic region (about GC identifiers)

Start:	51,500,254 bp from pter
End:	51,630,807 bp from pter
Size:	130,554 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000015.9 NT_010194.17

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene, Novus Biologicals, and/or Sino Biological,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 May 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abnova, OriGene, Novus Biologicals, and/or Epitomics)
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UniProtKB/Swiss-Prot: CP19A_HUMAN, P11511 (See protein sequence)

Recommended Name: Cytochrome P450 19A1

Size: 503 amino acids; 57883 Da

Cofactor: Heme group

Subcellular location: Membrane; Peripheral membrane protein

PDB structure from and Proteopedia :

1TQA (3D)

3EQM (3D)

Secondary accessions: Q16731 Q3B764 Q58FA0

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_000094.2 NP_112503.1

ENSEMBL proteins:

ENSP00000391975 ENSP00000379685 ENSP00000260433 ENSP00000379683 ENSP00000391139 ENSP00000384389

ENSP00000383930 ENSP00000390614

Human Recombinant Proteins

	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Enzo Life Sciences proteins for CYP19A1
	HuPro® and/or Recombinant Proteins from Abnova for CYP19A1
	Browse Origene full length recombinant human proteins expressed in human HEK293 cells
	Novus Biologicals Proteins for CYP19A1
	Novus Biologicals Lysate for CYP19A1
	Browse Sino Biological Recombinant Proteins

4 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005624	membrane fraction	TAS	2848247
GO:0005783	endoplasmic reticulum	IDA	11256614
GO:0016020	membrane	IEA	--
GO:0019898	extrinsic to membrane	--	--

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CYP19A1 for ontologies About GeneDecksing

Antibodies for CYP19A1:

	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for CYP19A1
	Browse R&D Systems for Antibodies
	Monoclonal and Polyclonal Antibodies from Abnova (CYP19A1)
	Origene Antibodies (see all 2): CYP19A1
	Novus Biologicals Antibodies for CYP19A1
	Browse antibodies at Epitomics

Assays for CYP19A1:

	Browse Kits and Assays available from Millipore
	Browse ELISAs at Sigma-Aldrich
	Browse R&D Systems for biochemical assays
	Enzo Life Sciences assays for CYP19A1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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CYP19A1 for domains About GeneDecksing

4 InterPro domains/families:

IPR001128 Cyt_P450

IPR017973 Cyt_P450_C

IPR017972 Cyt_P450_CS

IPR002401 Cyt_P450_E_grp-I

Graphical View of Domain Structure for InterPro Entry P11511

ProtoNet protein and cluster: P11511

UniProtKB/Swiss-Prot: CP19A_HUMAN, P11511

Similarity: Belongs to the cytochrome P450 family

(According to MGI May 08 2010, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, Abnova, siRNAs from Applied Biosystems, Sigma-Aldrich, Clones from Millipore, Sigma-Aldrich, OriGene, Sino Biological, Ontologies according to Gene Ontology Consortium 01 May 2010 via Entrez Gene.)
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Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CYP19A1)
		Origene 29mer shRNA kits in GFP-retroviral vector: CYP19A1 Origene shRNA RFP: CYP19A1 Origene basic RS shRNA: CYP19A1
		Applied Biosystems Silencer® siRNAs for CYP19A1
		Sigma-Aldrich siRNA Panels and siRNA for CYP19A1 Sigma-Aldrich shRNA for CYP19A1 Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
		Browse iPSC Reprogramming Factors at Sigma-Aldrich
		Origene GFP tagged cDNA clones in CMV expression vector (see all 2): CYP19A1 Origene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): CYP19A1 Origene untagged cDNA clones in CMV expression vector (see all 2): CYP19A1
		Browse Sino Biological Human cDNA Clones

UniProtKB/Swiss-Prot: CP19A_HUMAN, P11511

Function: Catalyzes the formation of aromatic C18 estrogens from C19 androgens

Catalytic activity: RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O

Enzyme Number (IUBMB): EC 1.14.14.1

5/8 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 8 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004497	monooxygenase activity	--	--
GO:0005506	iron ion binding	--	--
GO:0009055	electron carrier activity	TAS	2848247
GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	TAS	1371509
GO:0019825	oxygen binding	TAS	2848247

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CYP19A1 for ontologies About GeneDecksing

Animal Models: 15/18 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Cyp19a1) (see all 18 ):

adipose tissue	behavior/neurological	cardiovascular system	cellular	endocrine/exocrine gland
growth/size	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system
liver/biliary system	muscle	nervous system	normal	pigmentation

CYP19A1 for phenotypes About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, Applied Biosystems GeneAssist, KEGG and/or UniProtKB, (map by GeneGo),
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 May 2010 via Entrez Gene).
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CYP19A1 for pathways About GeneDecksing

2 Millipore Pathways for CYP19A1

	Transcription Role of VDR in regulation of genes involved in osteoporosis
	Estrogen biosynthesis

5/8 Sigma-Aldrich "Your Favorite Gene" Pathways for CYP19A1 (Your Favorite Gene powered by Ingenuity) (see all 8 )

	Metabolism of Xenobiotics by Cytochrome P450
	Linoleic Acid Metabolism
	FXR/RXR Activation
	Fatty Acid Metabolism
	Tryptophan Metabolism

2 Kegg Pathways (Kegg details for CYP19A1):

	hsa00140 Steroid hormone biosynthesis
	hsa01100 Metabolic pathways

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CYP19A1

5/53 Interacting proteins for CYP19A1 (ENSP00000260433³ P11511²) via UniProtKB, MINT, and/or STRING (see all 53 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
A2M	P01023²	MINT-4054731
ACTB	P60709²	MINT-4054731
ALPP	P05187²	MINT-4054731
APOD	P05090²	MINT-4054731
ARL8B	Q9NVJ2²	MINT-4054731

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4 Gene Ontology (GO) biological process terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006694	steroid biosynthetic process	EXP	15583024
GO:0008209	androgen metabolic process	--	--
GO:0055114	oxidation reduction	IEA	--
GO:0060736	prostate gland growth	--	--

About this table

CYP19A1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
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CYP19A1 for compounds About GeneDecksing

Enzo Life Sciences drugs & compounds for CYP19A1

Sigma-Aldrich Small Molecules for CYP19A1:

Small Molecule - Inhibitor Small Molecule - Ligand

Compounds for CYP19A1 available from Tocris Bioscience

Compound	Action	CAS number
YM 511	Potent aromatase (CYP19) inhibitor	[148869-05-0]
Anastrozole	Potent aromatase (CYP19) inhibitor	[120511-73-1]

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10/819 Novoseek chemical compound relationships for CYP19A1 gene (see all 819 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
3beta-hydroxysteroid	100.00	144	17548088 (3), 9571011 (2), 8364162 (2), 8013361 (2) (see all 100)
17beta-hydroxysteroid	100.00	156	9929167 (4), 11205867 (3), 9626631 (2), 6325047 (2) (see all 100)
fulvestrant	100.00	83	16912252 (3), 10598045 (3), 19645779 (2), 19137123 (2) (see all 71)
4-hydroxyandrostenedione	100.00	237	9797017 (3), 7781147 (3), 9484813 (2), 9459198 (2) (see all 100)
aminoglutethimide	100.00	280	3129284 (7), 3921242 (6), 3755630 (6), 16244789 (6) (see all 100)
anastrozole	100.00	448	9522927 (4), 16263272 (4), 11900212 (4), 11329794 (4) (see all 100)
letrozole	100.00	500	9878997 (4), 9556790 (4), 19217534 (4), 16263272 (4) (see all 100)
testosterone	100.00	1121	2328827 (9), 11850230 (7), 9619844 (5), 9625355 (4) (see all 100)
estrone	100.00	213	15456920 (5), 2796962 (4), 8476770 (3), 6725522 (3) (see all 100)
fadrozole	100.00	274	9459198 (5), 8476776 (5), 8045368 (4), 7621894 (4) (see all 100)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 223 Homo sapiens; Apr 2 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from SABiosciences,
Tagged/untagged cDNA clones from OriGene, Primers from OriGene and/or SABiosciences,
Expression Assays from Applied Biosystems)
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Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CYP19A1)
		Applied Biosystems Silencer® siRNAs: NM_000103 NM_031226
		Origene 29mer shRNA kits in GFP-retroviral vector: CYP19A1 Origene shRNA RFP: CYP19A1 Origene basic RS shRNA: CYP19A1
		Sigma-Aldrich siRNA Panels and siRNA for CYP19A1 Sigma-Aldrich shRNA for CYP19A1 Explore Sigma-Aldrich super-pooled esiRNAs

microRNA:		9 SABiosciences microRNAs that regulate CYP19A1:
		hsa-miR-98 hsa-let-7d hsa-let-7c hsa-let-7i hsa-let-7e hsa-let-7g hsa-let-7b hsa-let-7a hsa-let-7f

Assays:

Applied Biosystems TaqMan® Gene Expression Assays:

NM_000103 NM_031226

Clones:

Origene GFP tagged cDNA clones in CMV expression vector (see all 2): CYP19A1
Origene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): CYP19A1
Origene untagged cDNA clones in CMV expression vector (see all 2): CYP19A1

Primers:		Origene genome-wide validated SYBR primer pairs: CYP19A1
		SABiosciences RT2 qPCR Primer Assay for CYP19A1: PPH00132A

REFSEQ mRNAs for CYP19A1 gene (2 alternative transcripts):

NM_000103.3 NM_031226.2

Additional cDNA sequence:

AK291778.1 BC020767.1 BC022896.1 BC035714.1 BC035959.1 BC056258.1 BC107785.1 CR591944.1

CR594831.1 CR610414.1 CR615188.1 CR617535.1 CR617751.1 CR619515.1 CR620604.1 CR621023.1

CR622060.1 CR622116.1 DQ118405.1 J04127.1 M18856.1 M22246.1 M28420.1 S52789.1

S52793.1 S52794.1 S58866.1 S85075.1 S96437.1 X13589.1 Y07508.1

24/62 DOTS entries (see all 62 ):

DT.449261 DT.100676727 DT.95300279 DT.101970966 DT.100869537 DT.91861766 DT.121057178 DT.100854649

DT.100676716 DT.121057260 DT.121057258 DT.303062 DT.40215192 DT.91787024 DT.100676720 DT.100676725

DT.121057024 DT.100660172 DT.121056960 DT.70102672 DT.121057151 DT.92416133 DT.121057217 DT.70101056

24/577 AceView cDNA sequences (see all 577 ):

S52793 BX339221 BG572661 BG434800 BG572026 CR619515 S52794 H03482

R32427 CF527879 BG572583 CR620604 BU751802 N54268 BX339518 CR622116

BX360406 NM_031226 D79084 BX379105 BG572328 BQ023342 NM_000103 BG619920

highest scoring ESTs for CYP19A1:

X13589 AA368214 AL540982 AL541360 AL541373 AL543759 AL551641 AU100175 BC020767 BC022896

Unigene Cluster for CYP19A1:

Cytochrome P450, family 19, subfamily A, polypeptide 1

Hs.260074 [show with all ESTs]

Unigene Representative Sequence: NM_031226

GeneLoc Exon Structure

5/12 Alternative Splicing Database (ASD) splice patterns (SP) for CYP19A1 (see all 12 )

ExUns:	1	^	2a	·	2b	^	3a	·	3b	^	4	^	5	^	6	^	7	^	8a	·	8b	^	9a	·	9b	^	10a	·	10b	^	11	^	12a	·	12b	·	12c	^	13a	·	13b	^	14	^	15a	·	15b	^	16a	·	16b	^
SP1:																			-																		-										-
SP2:																																					-										-
SP3:											-		-		-		-		-
SP4:																																					-
SP5:			-		-		-		-		-		-		-		-		-

ExUns:	17
SP1:
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for CYP19A1

11 Ensembl transcripts including schematic representations:

ENST00000420301 ENST00000396404 ENST00000260433 ENST00000396402 ENST00000453807 ENST00000478421

ENST00000405011 ENST00000490076 ENST00000492852 ENST00000405913 ENST00000439712

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 223 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems, Primers from OriGene and/or SABiosciences )
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CYP19A1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for CYP19A1

¹ / ² / ³

12 probe-sets matching CYP19A1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
987_g_at²^{, 3}	U95-A	1	1.00	1.00	0.59	1.04	X13589	1.00	1.00	1.00	1
986_at²^{, 3}	U95-A	1	1.00	1.00	0.96	1.29	X13589	1.00	1.00	1.00	1
38039_at²^{, 3}	U95-A	1	1.00	1.00	0.56	0.37	M22246	0.80	1.00	0.91	1
1619_g_at²^{, 3}	U95-A	1	1.00	1.00	0.70	1.18	D21241	0.20	1.00	0.72	1
42790_at²	U95-B	1	0.94	1.00	0.21	0.91	--	--	--	--	--
44388_at²^{, 3}	U95-B	1	0.50	1.00	0.66	0.73	AA628233	0.60	1.00	0.82	1
64527_at²^{, 3}	U95-C	1	0.44	1.00	0.39	0.19	H13091	0.80	1.00	0.91	1
1618_at*²^{, 3}	U95-A	1	--	--	0.58	0.33	D21241	0.20	1.00	0.72	1
203475_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000103	0.60	1.00	0.82	1
203475_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1554296_at²	U133Plus2	1	0.36	1.00	--	--	--	--	--	--	--
1560295_at*²	U133Plus2	1	0.36	1.00	--	--	--	--	--	--	--

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CYP19A1 for expression About GeneDecksing

Data from Genenote (Publications) and GNF BioGPS
About these images

About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.260074

Expression variation in blood from EXPOLDB for CYP19A1

UniProtKB/Swiss-Prot: CP19A_HUMAN, P11511

Tissue specificity: Brain, placenta and gonads

Primers:		Origene genome-wide validated SYBR primer pairs: CYP19A1
		SABiosciences RT2 qPCR Primer Assay for CYP19A1: PPH00132A

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI May 08 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for CYP19A1 gene from 5/9 species (see all 9 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	CYP19¹	--	aromatase	87.98(n) 86.25(a)	494003 NM_001008715.1 NP_001008715.1
chimpanzee (Pan troglodytes)	CYP19A1¹	--	cytochrome P450, family 19, subfamily A, polypeptide more	99.8(n) 99.8(a)	453433 XM_001169384.1 XP_001169384.1
cow (Bos taurus)	CYP19¹	--	cytochrome P450, family XIX (conversion of androgen more	86.39(n) 84.06(a)	281740 NM_174305.1 NP_776730.1
rat (Rattus norvegicus)	Cyp19a1¹	--	cytochrome P450, family 19, subfamily a, polypeptide more	80.69(n) 77.85(a)	25147 NM_017085.1 NP_058781.1
mouse (Mus musculus)	Cyp19a1⁵ Cyp19a1¹	9 (31.00 cM)⁵	cytochrome P450, family 19, subfamily a, polypeptide more^{1, 5}	81.41(n)¹ 79.48(a)¹	13075¹ NM_007810.2¹ NP_031836.1¹ AK143323⁵ BC103670⁵ (see all 13)

About this table Species with no ortholog for CYP19A1

ENSEMBL Gene Tree for CYP19A1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Genotyping Reagents from Applied Biosystems)
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10/1180 NCBI SNPs in CYP19A1 are shown (see all 1180 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 476)

AB	SNP ID	Valid	Chr 15 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Related Data				Allele Frequencies
				--	--	--		--	--			--
	rs10046^1,2	C,F,A,H	51502986(-)	`GTACCC/TACTCT`	2	--	ut3¹ ese³		31	MN EA NS NA WA	6880
	rs934633^1,2	C,F,O,A	51500494(+)	`TTCCAC/TTTGAG`	2	--	ut3¹		12	MN NS EA NA	946
	rs4646^1,2	C,F,A,H	51502844(+)	`ATGACC/AAATAG`	2	--	ut3¹		41	EA CSA EU CSAM NA MN NS WA	6920
	rs6493497^1,2	C,F,A,H	28460912(+)	`catttG/Attgtc`	1	--	ng5¹		15	NS EA NA WA	3634
	rs4775936^1,2	C,F,A	28366207(+)	`TTTTTC/TAACAT`	2	--	ng5¹ int¹		21	NA NS EA	1898
	rs2255192^1,2	C,F,A	51500835(+)	`ACAGGC/TTAAGC`	2	--	ut3¹		16	EA NS NA WA	2420
	rs10851498^1,2	C,F,A	28367197(+)	`agatgT/Ctgcaa`	2	--	ng5¹ int¹		12	NS EA NA WA	1018
--	rs7176005^1,2	C,F,A	28461356(+)	`ttcaAC/TGGGTA`	1	--	ng5¹		5	NA EA WA	3090
	rs934634^1,2	C,F,A	51500538(+)	`GGTGTC/TTAGCA`	2	--	ut3¹		18	MN EA NS NA WA	2866
	rs752760^1,2	C,F,A	28461556(+)	`TCTGCT/CTGTCT`	1	--	ng5¹		9	NS EA NA WA	634

About this table

HapMap Linkage Disequilibrium images for CYP19A1 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for CYP19A1
5 CNVs: 102102 72248 3081 8798 3963
1 Indel: 33603

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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CYP19A1 for disorders About GeneDecksing

OMIM: 107910

UniProtKB/Swiss-Prot: CP19A_HUMAN, P11511

Defects in CYP19A1 are a cause of familial gynecomastia [MIM:139300]. This is characterized by an estrogen

excess due to an increased aromatase activity

Defects in CYP19A1 are the cause of aromatase deficiency (AROD) [MIM:107910]. AROD is a rare disease in which

fetal androgens are not converted into estrogens due to placental aromatase deficiency. Thus, pregnant women exhibit a

hirsutism, which spontaneously resolves after post-partum. At birth, female babies present with pseudohermaphroditism

due to virilization of extern genital organs. In adult females, manifestations include delay of puberty, breast

hypoplasia and primary amenorrhoea with multicystic ovaries

10/509 Novoseek disease relationships for CYP19A1 gene (see all 509 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
breast cancer	100.00	2451	19906814 (8), 17440110 (8), 16471323 (8), 17624762 (7) (see all 100)
endometriosis	100.00	227	9024261 (6), 8550748 (6), 18048499 (5), 16806212 (5) (see all 100)
aromatase deficiency	100.00	160	20164294 (5), 19707181 (4), 16439592 (4), 10843162 (4) (see all 100)
breast tumor	100.00	246	9010331 (5), 9797023 (4), 19800002 (4), 10629706 (4) (see all 100)
aromatase activity, increased	100.00	105	16394175 (3), 7060521 (2), 3090186 (2), 1889004 (2) (see all 96)
breast cancer metastatic	66.12	117	9786093 (3), 16940812 (3), 11129731 (3), 9350235 (2) (see all 97)
endometrial cancer	41.30	132	8476761 (5), 7856758 (5), 17404019 (5), 15939586 (4) (see all 73)
estrogen resistance	32.22	15	9554463 (2), 7670243 (1), 19528961 (1), 16556720 (1) (see all 14)
choriocarcinoma	26.74	58	3181871 (4), 9328212 (3), 12050258 (3), 9528950 (2) (see all 41)
gynecomastia	24.31	42	18426832 (4), 8768875 (3), 10731125 (3), 9589695 (2) (see all 32)

About this table

Locus Specific Mutation Databases: CYP19A1
Human Gene Mutation Database: CYP19A1
Genetic Association Database: CYP19A1
Human Genome Epidemiology Navigator: CYP19A1 (220 documents)

(Possibly Related Articles in Doctor's Guide)
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(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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39/2343 PubMed articles for CYP19A1 gene (see all 2343 ):

CYP1B1 and CYP19 gene polymorphisms and breast cancer incidence: no association in the ARIC study. (PubMed id 15072827)^{1, 3, 6} Thyagarajan B....Gross M. (2004)
Interaction between CYP19 aromatase and butyrylcholinesterase genes increases Alzheimer's disease risk. (PubMed id 16020944)^{1, 3, 6} Combarros O....Berciano J. (2005)
Association of the genetic polymorphism of the CYP19 intron 4[TTTA]n repeat with familial prostate cancer risk in a Japanese population. (PubMed id 14981949)^{1, 3, 6} Suzuki K....Yamanaka H. (2003)
Genetic polymorphisms of estrogen receptor alpha, CYP19, catechol-O-methyltransferase are associated with familial prostate carcinoma risk in a Japanese population. (PubMed id 14508827)^{1, 3, 6} Suzuki K....Yamanaka H. (2003)
CYP19 gene polymorphism in endometrial cancer patients. (PubMed id 11216915)^{1, 3, 6} Berstein L.M....Gamajunova V.B. (2001)
Phytoestrogen exposure correlation with plasma estradiol in postmenopausal women in European Prospective Investigation of Cancer and Nutrition-Norfolk may involve diet-gene interactions. (PubMed id 15668497)^{1, 3, 6} Low Y.L....Bingham S.A. (2005)
CYP19 (aromatase) haplotypes and endometrial cancer risk. (PubMed id 15800924)^{1, 3, 6} Paynter R.A....De Vivo I. (2005)
CYP17 and CYP19 genetic polymorphisms in endometrial cancer: association with intratumoral aromatase activity. (PubMed id 15072828)^{1, 3, 6} Berstein L.M....Thijssen J.H. (2004)
Association of CYP17, CYP19, CYP1B1, and COMT polymorphisms with serum and urinary sex hormone concentrations in postmenopausal women. (PubMed id 14744739)^{1, 3, 6} Tworoger S.S....McTiernan A. (2004)
[Association of polymorphism of genetic markers of CYP19 and CYP17 with sporadic breast cancer] (PubMed id 14714492)^{1, 3, 6} Artamonov V.V....Zaletaev D.V. (2003)
A new SNP in a negative regulatory region of the CYP19A1 gene is associated with lumbar spine BMD in postmenopausal women. (PubMed id 16344016)^{1, 3, 6} Enjuanes A....Diez-Perez A. (2006)
Association study of aromatase gene (CYP19A1) in essential hypertension. (PubMed id 18274619)^{1, 3} Shimodaira M....Izumi Y. (2008)
Haplotype analyses of CYP19A1 gene variants and breast cancer risk: results from the Shanghai Breast Cancer Study. (PubMed id 18199708)^{1, 3} Cai Q....Zheng W. (2008)
Association of FSH receptor and CYP19A1 gene variations with sterility and ovarian hyperstimulation syndrome. (PubMed id 18159088)^{1, 3} Binder H....Strick R. (2008)
Genetic polymorphisms of the CYP19A1 gene and breast cancer survival. (PubMed id 17119036)^{1, 3} Long J.R....Zheng W. (2006)
Interaction of soy food and tea consumption with CYP19A1 genetic polymorphisms in the development of endometrial cancer. (PubMed id 17827443)^{1, 3} Xu W.H....Shu X.O. (2007)
CYP19A1 genetic polymorphisms may be associated with obesity-related phenotypes in Chinese women. (PubMed id 16894362)^{1, 3} Long J.R....Zheng W. (2007)
Polymorphisms in the CYP19A1 (aromatase) gene and endometrial cancer risk in Chinese women. (PubMed id 17507620)^{1, 3} Tao M.H....Shu X.O. (2007)
Genetic polymorphisms in CYP17, CYP3A4, CYP19A1, SRD5A2, IGF-1, and IGFBP-3 and prostate cancer risk in African-American men: the Flint Men's Health Study. (PubMed id 18163429)^{1, 3} Sarma A.V....Cooney K.A. (2008)
Association of two common single-nucleotide polymorphisms in the CYP19A1 locus and ovarian cancer risk. (PubMed id 18667686)^{1, 3} Goodman M.T....Carney M.E. (2008)
Polymorphisms in the cytochrome P450 genes CYP1A2, CYP1B1, CYP3A4, CYP3A5, CYP11A1, CYP17A1, CYP19A1 and colorectal cancer risk. (PubMed id 17615053)^{1, 3} Bethke L....Houlston R. (2007)
[Effect of R264C polymorphism in CYP19A1 gene on BRCA1/2-negative hereditary breast cancer from Shanghai population of China] (PubMed id 16604491)^{1, 3} Song C.G....Shao Z.M. (2006)
Aromatase gene (CYP19A1) variants, female infertility and ovarian stimulation outcome: a preliminary report. (PubMed id 19549443)^{1, 3} AltmAoe S....Salumets A. (year=2009;month=May;day=)
Association of genetic polymorphisms in CYP19A1 and blood levels of sex hormones among postmenopausal Chinese women. (PubMed id 18622258)^{1, 3} Cai H....Zheng W. (2008)
Single nucleotide polymorphisms of the aromatase gene (CYP19A1), HER2/neu status, and prognosis in breast cancer patients. (PubMed id 18049890)^{1, 3} Fasching P.A....Strick R. (2008)
Sex and body mass index specific regulation of blood pressure by CYP19A1 gene variants. (PubMed id 17893373)^{1, 3} Ramirez-Lorca R....Serrano-Rios M. (2007)
Modulation of human CYP19A1 activity by mutant NADPH P450 oxidoreductase. (PubMed id 17595315)^{1, 3} Pandey A.V....Fluck C.E. (2007)
Association between CYP19A1 polymorphisms and sex hormones in postmenopausal Japanese women. (PubMed id 19158807)³ Kidokoro K....Matsuo K. (2009)
Association of polymorphisms in CYP19A1 and CYP3A4 ge nes with lower urinary tract symptoms, prostate volume, uroflow and PSA in a po pulation-based sample. (PubMed id 19921206)³ Berges R....Madersbacher S. (2009)
Alternative 5'-untranslated first exons of the mouse Cyp19A1 (aromatase) gene. (PubMed id 19500729)³ Chow J.D....Boon W.C. (2009)
Two estrogen-related variants in CYP19A1 and endometrial cancer risk: a pooled analysis in the Epidemiology of Endometrial Cancer Consortium. (PubMed id 19124504)³ Setiawan V.W....Olson S.H. (2009)
Genetic variation in CYP19A1 and risk of breast cancer and fibrocystic breast conditions among women in Shanghai, China. (PubMed id 19064562)³ Chen C....Thomas D.B. (2008)
CYP19A1 polymorphisms are associated with bone mineral density in Chinese men. (PubMed id 17216495)³ Hong X....Xu X. (2007)
Genetic variation at the CYP19A1 locus predicts circulating estrogen levels but not breast cancer risk in postmenopausal women. (PubMed id 17325027)³ Haiman C.A....Ziegler R.G. (2007)
CYP19A1 genetic variation in relation to prostate can cer risk and circulating sex hormone concentrations in men from the Breast and Prostate Cancer Cohort Consortium. (PubMed id 19789370)³ Travis R.C....Hunter D.J. (year=2009;month=Oct;day=)
In vitro kinetic properties of the Thr201Met variant of human aromatase gene CYP19A1: functional responses to substrate and product inhibition and enzyme inhibitors. (PubMed id 19470632)³ Payne E.J....Prince R.L. (year=2009;month=Aug;day=)
Gene-wide association study between the aromatase gen e (CYP19A1) and female pattern hair loss. (PubMed id 19438456)³ Yip L....Ellis J. (year=2009;month=Aug;day=)
Tissue- and sex-specific regulation of CYP19A1 expression in the Atlantic croaker (Micropogonias undulatus). (PubMed id 16872606)¹ Nunez B.S. and Applebaum S.L. (2006)
Distinct regulation by steroids of messenger RNAs for FSHR and CYP19A1 in bovine granulosa cells. (PubMed id 16641147)¹ Luo W. and Wiltbank M.C. (year=2006;month=Aug;day=)

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		AND	OR
Aliases
Disorders
Search String
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 1588	HGNC: 2594	AceView: CYP19A1	Ensembl:ENSG00000137869	euGenes: HUgn1588
ECgene: CYP19A1	Kegg: 1588	H-InvDB: CYP19A1

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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Name	Description
ATLAS Chromosomes in Cancer entry for CYP19A1	Genetics and Cytogenetics in Oncology and Haematology
Wikipedia	http://en.wikipedia.org/wiki/Aromatase
GeneReviews	http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/CYP19A1
NIEHS-SNPs	http://egp.gs.washington.edu/data/cyp19a1/

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CYP19A1 (Gene Symbol)
cytochrome P450, family 19, subfamily A, polypeptide 1
ARO1
CYAR
ARO
CYP19
cytochrome P450, subfamily XIX (aromatization of androgens)
P-450AROM
aromatase
CPV1
Cytochrome P-450AROM
Estrogen synthase
CYPXIX
flavoprotein-linked monooxygenase
MGC104309
cytochrome P450 19A1
microsomal monooxygenase
estrogen synthetase
Aromatase
EC 1.14.14.1

adenomyosis
breast mouse
cartilaginous tumor
pregnancy loss
malformation
lung tumor
uterine hypertrophy
leydig cell hyperplasia
adrenal disease
benign ovarian tumor
relapse
chronic sialadenitis
hormone receptor positive tumor
factor v leiden
endometrioma
unexplained infertility
epilepsies
insufficiency; placental
cholestasis intrahepatic
neurodegenerative disease
autosomal dominant hereditary disorder
COPD
atherosclerosis
adrenal carcinoma
premalignant lesion
nonsense mutation
colorectal adenocarcinoma
leiomyomatosis peritonealis disseminata
genitourinary abnormalities
dysplasia; hip
gene fusion
high-risk pregnancies
neuroblastoma
human mammary carcinoma
estrogenic effect
malignant disease
failure heart
pregnancy; tubal
lymphoma
cancer regression
hypergonadism
heterotopia
precocious puberty, male-limited
ovarian cancer
breast cyst
chronic pain syndrome
erythema nodosum
epithelial proliferation
leiomyoma
cognitive impairment
osteoporosis postmenopausal
cystic ovaries
male pseudohermaphroditism
localized cancer
atherogenesis
hamartoma
endometrial tumor
hand osteoarthritis
dysfunction ovarian
pelvic endometriosis
sex cord-stromal tumor
demineralization; bone
immunosuppression
metabolic syndrome
metastasis
degenerative
adenocarcinoma endometrial
necrosis
cell injury
menopause ovarian failure
impaired wound healing
lymph node metastasis
prostatic disease
hyperandrogenism
growth delay
prostate tumor
testis cancer
colon cancer
hyperprolactinemia
macroorchidism
middle cerebral artery occlusion
obstruction; prostatic
contralateral breast cancer
infection; salmonella
epithelial tumor
thyroid cancer
abortion (spontaneous)
albino
osteosarcoma
osteoporosis
tumor initiation
endocrinopathy
female infertility
prostatitis
17 alpha-hydroxylase deficiency
gonadal dysfunction
endometrial stromal sarcoma
granulosa cell tumor
aromatase activity, increased
pituitary tumor
breast cancer recurrent
gh deficiency
hypoplasia
sertoli-leydig cell tumor
adrenocortical carcinoma
immune dysfunction
ovarian endometriosis
undifferentiated carcinoma
menstrual irregularities
benign tumor
partial androgen insensitivity syndrome
menorrhagia
amenorrhea primary
ovarian granulosa cell tumor
multiple myeloma
dilatations
gingival overgrowth
invasive breast cancer
vascular disease
disorder; growth
choriocarcinoma
bone disease
lupus erythematosus systemic
fatty liver
phocas
poems syndrome
brain disease
fibromatosis; retroperitoneal
infertility
growth suppression
sepsis
intravenous leiomyomatosis
malaria
benign prostatic hypertrophy
rheumatic disease
wallerian degeneration
sarcoma, endometrial stromal, low-grade
inflammatory disease
stromal tumor
pubertal gynecomastia
peutz-jegher syndrome
skin; appendage
insulin sensitivity
lung cancer
breast cancer
hypogonadotrophic hypogonadism
comt, val158met
dysgerminoma
hypercholesterolemia
tumor promotion
acute infection
bone loss
androgen deficiency
ankylosing; arthritis
shock
ambiguous external genitalia
recurrent miscarriage
incomplete testicular feminization syndrome
fatty infiltration
fibroma
dominant-negative mutant
colorectal cancer
delayed-type hypersensitivity
cutaneous vasculitis
short stature
androgen excess
hypertension
uterine abnormalities
impaired sexual behavior
cysts
idiopathic osteoporosis
cervical cancer
disease regression
cancer other
sicca
morbid obesities
entrapment neuropathies
innate immune response
thrombosis
extravasation
placental choriocarcinoma
prostatic adenocarcinoma
abuse; drug
precocious puberty
aromatase deficiency
breast cancer metastatic
cardiovascular disease
finger trigger
transgenic model
deficiency; folate
hypertension, pregnancy-induced
gastric cancer
gynecologic cancer
disorder; reproductive
melanoma
abnormal pregnancy
oedema peripheral
tumor progression
glioma
hormone-refractory prostate cancer
aldosteronism primary
uterine sarcoma
ovarian cancer recurrent
idiopathic hypogonadotropic hypogonadism
congenital adrenal hypoplasia
carcinoma endometrial recurrent
artificial menopause
hormone replacement
anovulatory
disease parkinsons
varicose vein
obese
uterine tumor
disease; inflammatory bowel
eruption
dysmetabolic syndrome
fibrolamellar hepatocellular carcinoma
apeced
leydig cell tumor
undifferentiated neuroblastoma
osteoporosis (osteopenia)
panhypopituitarism
atypical proliferation
aggressive behavior
ovary; polycystic (syndrome)
juvenile idiopathic arthritis
deficiency; growth hormone
anastomosis
meningioma
malignant blue nevus
paraneoplastic syndrome
enzyme inhibition
insulin resistance
endometrial disease
klinefelter syndrome
disease; lung
breast disease
pelvic tumor
azoospermia, nonobstructive
metastatic prostate cancer
cyst; ovarian
solid tumor
inflammatory carcinoma
ambiguous genitalia
erythema multiforme
mucinous cystadenocarcinoma
microcephalies
conduct disorder
granular cell tumor
leukemia myeloid
delay; developmental
serous carcinoma
hyperplastic nodule
trophoblastic tumor
fibrothecoma
endometrial hyperplasia
caruncle
death fetal
blue nevi
endometrial cancer
granulosa cell cancer
delivery preterm
adenosis sclerosing
brca1 mutation
glucose tolerance impaired
dysmenorrhea
tumor lysis syndrome
disease; musculoskeletal
embolism pulmonary
single gene defect
pain syndrome
endometriosis
dysplasia
tumor growth
lymphedema
dyspareunia
acne
feminization
hyperthyroidism
hypothyroidism primary
nsclc
primary tumor
ovarian serous cystadenocarcinoma
ureteral obstruction
abdominal obesity
cancer
obstruction
tumor necrosis
multinodular goiter
adenoma; pituitary
steroid cell tumor
embryonal carcinoma
testosterone deficiency
growth arrest
endocrine cancer
hyperestrogenism
oncogenesis
ductal hyperplasia
invasive lobular carcinoma
atrophies
polyp
por deficiency
contraction; bladder
gynecomastia
climacteric syndrome
bipolar disorder
circulation; fetal
nasopharyngeal juvenile angiofibroma
sclerosing stromal tumor
breast cancer, familial
idiopathic gynecomastia
hashimoto thyroiditis
lymphocytic infiltration
vitamin d deficiencies
cystadenoma mucinous
testotoxicosis
anovulation
idiopathic short stature
carcinogenicity
epithelial hyperplasia
syndrome; vasomotor
hyperplasia
multiple cancer
germinoma
atherosclerotic plaque
ovarian hyperstimulation
benign prostate hyperplasia
macronucleus
cardiovascular complication
RA
ohss
breast cancer stage iii
prostatic hypertrophy
estrogen deficiency
squamous cell carcinoma
leukemia
conventional chondrosarcoma
hydatidiform mole
diabetes mellitus
dyspepsia
ovarian failure premature
arteriosclerosis
cognitive deficit
oligozoospermia
uterine atrophy
pregnancy early
pancreatic cancer
maturation defect
cerebral ventricle
hypertrophies
adenoma
arteriovenous malformation
autoimmune thyroid disease
disease graves
xenograft model
leukemia prolymphocytic
CAD
autoimmune
mccune-albright syndrome
bilateral breast cancer
sporadic breast cancer
cryptorchidism
osteomalacia
pituitary macroadenoma
21-hydroxylase deficiency
rare disorder
ejaculation premature
breast cancer stage
amenorrhoea
dcis
malignant transformation
inflammatory response
hyperinsulinemia
essential hypertension
placental aromatase deficiency
endometritis
plasma cell dyscrasia
bone; change
sclerosis
gynecologic disease
hyperlipidemia
pregnancy risk
hiv-lipodystrophy
diabetes; type 2
cytoplasmic droplets
cancer cell growth
schizophrenia
germ cell tumor
adenocarcinoma
seminoma
advanced cancer
venous thromboembolism
fracture; osteoporotic
aggressive angiomyxoma
tumor; wilms
ovarian disease
pseudohermaphroditism
dysfunction; sexual
early menopause
gender identity disorder
anabolic steroids
metastasizing leiomyoma
endometrial polyp
hemorrhage retinal
purpura
dyslipidemia
binucleate cell
malnutrition
inflammation
oppositional defiant disorder
idiopathic hirsutism
immunodeficiency
atypical endometrial hyperplasia
adrenal hyperplasia congenital
large cell calcifying sertoli cell tumor
effusion pleural
cyst; follicular
cancer recurrence
androgen insensitivity syndrome
leukemia monocytic
scorbutic
prostate cancer
mammary tumorigenesis
urine marking
thromboembolic event
carcinoma hepatocellular
sarcoma
adhd
hypersensitivities
glioblastoma
lymphoid tumor
fibroadenoma
carpal tunnel syndrome
ankylosing spondylitis
dwarf
mood disorder
androgenization
phenomenon; raynaud
cancer, treatment-related
hemorrhagic cyst
skin lines
lesion; skin
lung cancer stage i
adrenocortical tumor
malnutrition; maternal
mammary adenocarcinoma
aspiration pneumonia
invasive carcinoma
antley-bixler syndrome
hypogonadism male
prolactinoma
ovarian dysgenesis
uterine leiomyosarcoma
osteoarthritis
bacterial infection
isosexual precocious puberty
delayed puberty
uterine cancer
thrombosis venous
single tumor
leukopenia
vaginal carcinoma
portopulmonary hypertension
neurodegeneration
breast tumor
cysticercosis
anencephaly
uterine disease
nuclear accumulation
invasive ductal carcinoma
premature pubarche
heterosexual precocity
influenza
bleeding; uterine
adrenocortical adenoma
precancerous condition
generalized obesity
adenomatous hyperplasia
sertoli cell tumor
dysfunction testicular
AD
chronic subdural hematoma
estrogen resistance
niddm1
myoma
delayed ovulation
hyperplasia; prostate
infertility male
carney complex
adrenal tumor
large breast
preneoplastic change
allelic imbalance
thrombophilia
stroke
sexual infantilism
cholera
ovarian tumor
genetic disorder
synovitis
ovarian adenocarcinoma
testicular leydig cell tumor
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CYP19A1 Gene

protein-coding GIFtS: 64

Aliases & Descriptionsfor CYP19A1 gene

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Aliases &
Descriptions
for CYP19A1 gene

Summaries
for CYP19A1 gene

Genomic Views
for CYP19A1 gene

Proteins
for CYP19A1 gene

Protein Domains/
Families
for CYP19A1 gene

Gene Function
for CYP19A1 gene

Pathways & Interactions
for CYP19A1 gene

Drugs & Compounds
for CYP19A1 gene

Transcripts
for CYP19A1 gene

Expression
for CYP19A1 gene

Orthologs
for CYP19A1 gene

Paralogs
for CYP19A1 gene

Genomic Variants
for CYP19A1 gene

Disorders & Mutations
for CYP19A1 gene

Medical News
for CYP19A1 gene

Publications
for CYP19A1 gene

Intellectual Property
for CYP19A1 gene

Services
for CYP19A1 gene