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CYP17A1 Gene

protein-coding GIFtS: 66

GC10M104580

cytochrome P450, family 17, subfamily A, polypeptide 1
(Previous names: cytochrome P450, subfamily XVII (steroid 17-alpha-hydroxylase), adrenal hyperplasia )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: CYP17)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
CPT7 ^¹, ²
CYP17 ^², ³, ⁵
CYPXVII ^³
EC 1.14.99.9 ^³
OTTHUMP00000020382 ^²
P450-C17 ^³
P450C17 ^¹, ², ⁵
P450c17 ^³
S17AH ^¹, ², ³

Descriptions
Cytochrome P450 17A1 ^³
Steroid 17-alpha-monooxygenase ^², ³
cytochrome P450, family 17 ^²
cytochrome P450, family 17, subfamily A, polypeptide 1 ^²
cytochrome P450, subfamily XVII (steroid 17-alpha-hydroxylase), adrenal hyperplasia ^¹, ²
cytochrome p450 XVIIA1 ^²
steroid 17-alpha-hydroxylase/17,20 lyase ^²

External Ids
HGNC: 2593¹
Entrez Gene: 1586²
UniProtKB: P05093³
Ensembl: ENSG00000148795⁷

Search outside databases for aliases for CYP17A1 gene

Previous GC identifers: GC10M103823 GC10M104721 GC10M104254

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for CYP17A1:

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450

proteins are monooxygenases which catalyze many reactions involved in drug metabolism and

synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic

reticulum. It has both 17alpha-hydroxylase and 17,20-lyase activities and is a key enzyme in the

steroidogenic pathway that produces progestins, mineralocorticoids, glucocorticoids, androgens,

and estrogens. Mutations in this gene are associated with isolated steroid-17 alpha-hydroxylase

deficiency, 17-alpha-hydroxylase/17,20-lyase deficiency, pseudohermaphroditism, and adrenal

hyperplasia. [provided by RefSeq]

UniProtKB/Swiss-Prot: CP17A_HUMAN, P05093

Function: Conversion of pregnenolone and progesterone to their 17-alpha-hydroxylated products and

subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the

17-alpha-hydroxylation and the 17,20-lyase reaction. Involved in sexual development during fetal

life and at puberty

Gene Wiki entry for CYP17A1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the CYP17A1 gene

Entrez Gene cytogenetic band: 10q24.3 Ensembl cytogenetic band: 10q24.32 HGNC cytogenetic band: 10q24.3

CYP17A1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10M104580: (about GC identifiers)

Start:	104,580,278 bp from pter
End:	104,587,280 bp from pter
Size:	7,003 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000010.9 NT_030059.12

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: CP17A_HUMAN, P05093 (See protein sequence)

Recommended Name: Steroid 17-alpha-hydroxylase/17,20 lyase

Size: 508 amino acids; 57371 Da

Cofactor: Heme group

Subcellular location: Membrane (Potential). Membrane; Single-pass membrane protein

PDB structures from and Proteopedia :

2C17 (3D)

Secondary accessions: Q5TZV7

Post-translational modifications:

Phosphorylation is necessary for 17,20-lyase, but not for 17-alpha-hydroxylase activity¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_000093.1

ENSEMBL proteins:

ENSP00000358903

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Cytochrome P450 17A1)
	Human Recombinant Proteins from Abnova (CYP17A1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5/6 Gene Ontology (GO) cellular component terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005739	mitochondrion	IEA	--
GO:0005783	endoplasmic reticulum	NAS	9326943
GO:0005789	endoplasmic reticulum membrane	EXP	10406467
GO:0016020	membrane	IEA	--
GO:0030424	axon	IEA	--

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Antibodies for CYP17A1:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (Cytochrome P450 17A1), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (CYP17A1)
	Novus Biologicals Antibodies for CYP17A1

Assays for CYP17A1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P05093

ProtoNet protein and cluster: P05093

1 Blocks protein family: IPB002401 E-class P450 group I signature

UniProtKB/Swiss-Prot: CP17A_HUMAN, P05093

Similarity: Belongs to the cytochrome P450 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CYP17A1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CYP17A1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000102

Applied Biosystems Silencer® siRNAs for CYP17A1

Sigma-Aldrich siRNA and siRNA Panels for CYP17A1

Sigma-Aldrich shRNA for CYP17A1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for CYP17A1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_000102
Myc/DDK tagged cDNA clone in CMV expression vector: NM_000102
untagged cDNA clone in CMV expression vector: NM_000102

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000102

UniProtKB/Swiss-Prot: CP17A_HUMAN, P05093

Function: Conversion of pregnenolone and progesterone to their 17-alpha-hydroxylated products and

subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the

17-alpha-hydroxylation and the 17,20-lyase reaction. Involved in sexual development during fetal

life and at puberty

Catalytic activity: A steroid + AH(2) + O(2) = a 17-alpha-hydroxysteroid + A + H(2)O

Enzyme regulation: Regulated predominantly by intracellular cAMP levels

Enzyme Number (IUBMB): EC 1.14.99.9

1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Cyp17a1):

lethality-prenatal/perinatal

5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004497	monooxygenase activity	IEA	--
GO:0004508	steroid 17-alpha-monooxygenase activity	TAS	1347802
GO:0009055	electron carrier activity	IEA	--
GO:0019825	oxygen binding	TAS	2808364
GO:0020037	heme binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Sigma-Aldrich "Your Favorite Gene" Pathway for CYP17A1 (Your Favorite Gene powered by Ingenuity)

C21-Steroid Hormone Metabolism

GeneDecks CYP17A1 for the pathways selected above

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UniProtKB/Swiss-Prot: CP17A_HUMAN, P05093

Pathway: Lipid metabolism; steroid biosynthesis

Gene Network Central^TM Interacting Genes and Proteins Network for CYP17A1

5/47 Interacting proteins for CYP17A1 (ENSP00000358903³) via UniProtKB, MINT, and/or STRING (see all 47 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
POR	ENSP00000265302³	STRING (score=.995)
POMC	ENSP00000370171³	STRING (score=.991)
HSD3B1	ENSP00000358421³	STRING (score=.973)
HSD3B2	ENSP00000358424³	STRING (score=.973)
HSD17B3	ENSP00000364412³	STRING (score=.972)

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5 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006700	C21-steroid hormone biosynthetic process	IEA	--
GO:0006704	glucocorticoid biosynthetic process	IEA	--
GO:0007548	sex differentiation	TAS	9326943
GO:0009636	response to toxin	IEA	--
GO:0055114	oxidation reduction	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for CYP17A1

Sigma-Aldrich Small Molecules for CYP17A1:

Inhibitor

Browse Tocris compounds for CYP17A1
10/50 Novoseek chemical compound relationships for CYP17A1 gene (see all 50 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
3beta-hydroxysteroid	90.83	71	15730543 (2), 8550761 (2), 8943800 (1), 9851802 (1) (see all 65)
17-hydroxypregnenolone	90.78	13	12464253 (1), 12573809 (1), 8396144 (1), 14504283 (1) (see all 12)
dhea	85.35	86	9927319 (4), 10824109 (3), 8943800 (2), 9768686 (2) (see all 44)
17-hydroxyprogesterone	83.35	12	9211124 (2), 12464253 (1), 17386955 (1), 8969926 (1) (see all 10)
steroid	82.54	152	11358812 (3), 11440959 (3), 11036113 (2), 10070957 (2) (see all 99)
androstenedione	82.34	24	14504283 (2), 10919257 (1), 12915666 (1), 9029727 (1) (see all 19)
abiraterone acetate	78.37	4	18645193 (3), 19189435 (1), 19223900 (1)
16alpha-hydroxyprogesterone	77.58	1	17386955 (1)
17alpha-hydroxysteroid	71.82	1	8943800 (1)
progesterone	71.04	68	8948449 (3), 12464252 (3), 17484509 (3), 12423360 (3) (see all 43)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CYP17A1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CYP17A1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000102

Sigma-Aldrich siRNA and siRNA Panels for CYP17A1

Sigma-Aldrich shRNA for CYP17A1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000102

REFSEQ mRNAs for CYP17A1 gene:

NM_000102.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000102

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000102
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000102
                                 untagged cDNA clone in CMV expression vector: NM_000102

Additional cDNA sequence:

AK094106.1 AK289898.1 AK308466.1 AK312235.1 BC032843.1 BC062997.1 BC063388.1 BT020000.1

M14564.1

20 DOTS entries:

DT.95274034 DT.121299833 DT.95274043 DT.95118255 DT.455545 DT.75146340 DT.95274036 DT.100793744

DT.92443848 DT.95280371 DT.100793745 DT.121299706 DT.121299718 DT.121299769 DT.87014926 DT.91810671

DT.92443849 DT.92443850 DT.92443853 DT.91957907

24/166 AceView cDNA sequences (see all 166 ):

AV710594 AV704387 AV711286 AV711044 AA340586 AA340899 AA349302 AV711503

AV711168 AA349170 BI520509 BX508739 BX279660 AV708626 AV706727 AV708250

AV710929 AV708366 AV710102 AV706133 AV706512 BM559917 BC063388 AA340749

highest scoring ESTs for CYP17A1:

M14564 AU120851 BC032843 BC062997 BC063388 BI458918 BI827786 BI829004 BI829884 BI831667

Unigene Cluster for CYP17A1:

Cytochrome P450, family 17, subfamily A, polypeptide 1

Hs.438016 [show with all ESTs]

Unigene Representative Sequence: AK094106

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for CYP17A1 (see all 7 )

ExUns:	1a	·	1b	^	2	^	3a	·	3b	·	3c	^	4a	·	4b	·	4c	·	4d	^	5a	·	5b	^	6a	·	6b	·	6c	^	7	^	8	^	9a	·	9b
SP1:							-
SP2:							-														-		-
SP3:																					-		-
SP4:
SP5:																							-		-

About this scheme

ECgene alternative splicing isoforms for CYP17A1

1 Ensembl transcript including schematic representation:

ENST00000369887

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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CYP17A1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for CYP17A1

¹ / ² / ³

6 probe-sets matching CYP17A1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
31789_at²^{, 3}	U95-A	1	1.00	1.00	0.99	0.85	M14564	1.00	1.00	1.00	1
90804_at²^{, 3}	U95-D	1	1.00	1.00	0.42	0.43	AI269107	0.60	0.75	0.68	1
586_s_at²^{, 3}	U95-A	1	1.00	1.00	0.96	1.18	M31153	0.20	1.00	0.72	1
205502_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000102	0.60	1.00	0.82	1
205502_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1562573_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks CYP17A1 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
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CGAP SAGE TAG: GCCTGGCTGC

SOURCE GeneReport for Unigene cluster: Hs.438016
Expression variation in blood from EXPOLDB for CYP17A1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for CYP17A1 gene from 5/9 species (see all 9 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	LOC477807¹	--	similar to Cytochrome P450 17A1 (CYPXVII) (P450-C17) more	83.79(n) 78.94(a)	477807 XM_846133.1 XP_851226.1
chimpanzee (Pan troglodytes)	CYP17A1¹	--	cytochrome P450, family 17, subfamily A, polypeptide more	99.41(n) 99.61(a)	450141 NM_001009052.1 NP_001009052.1
cow (Bos taurus)	CYP17¹	--	cytochrome P450, subfamily XVII	80.12(n) 71.06(a)	281739 NM_174304.1 NP_776729.1
rat (Rattus norvegicus)	Cyp17a1¹	--	cytochrome P450, family 17, subfamily a, polypeptide more	76.2(n) 68.44(a)	25146 NM_012753.1 NP_036885.1
mouse (Mus musculus)	Cyp17a1^{1, 5}	19 (46.00 cM)⁵	cytochrome P450, family 17, subfamily a, polypeptide more^{1, 5}	74.75(n)¹ 66.86(a)¹	13074¹ NM_007809.2¹ NP_031835.2¹ AK132830⁵ AK134376⁵ (see all 12)

About this table Species with no ortholog for CYP17A1

ENSEMBL Gene Tree for CYP17A1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for CYP17A1 gene

CYP21A2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/130 NCBI SNPs in CYP17A1 are shown (see all 130 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 49)

AB	SNP ID	Valid	Chr 10 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs743572^1,2	A,C,F,H,O	104587142(+)	`ACAGCA/GGTGGA`	1	--	ut5¹ ese³		34		NA EA MN EU WA CSAM NS	4195
	rs2486758^1,2	C,F,H,O	104587470(+)	`CCATGT/CTGCAA`	1	--	ng3¹		23		NA MN EA EU WA CSAM NS	1918
	rs17115149^1,2	C,F,H	104587708(+)	`GGAACG/TAAAGG`	1	--	ng3¹		20		NA EU EA WA NS	1556
	rs762563^1,2	C,F,H	104587043(-)	`AGGTGC/GCCTGG`	1	C/W	mis¹ ese³		10		MN EU EA WA CSAM	1010
--	rs10786713^1,2	A,C	104588312(+)	`TGCACA/GTACTG`	1	--	ng3¹		0	--	--	--	--
	rs17115144^1,2	C,F	104587298(+)	`GAGGYG/AGTGGG`	1	--	ng3¹		13		NA MN CSAM EA NS	716
--	rs10786714^1,2	A,C	104588596(+)	`TGCATC/GTCCAT`	1	--	ng3¹		0	--	--	--	--
--	rs34103489^1,2	F	104587297(-)	`CCACYG/ACCTCT`	1	--	ng3¹		5		MN CSAM EA	396
--	rs45455494^1,2	F	104580283(-)	`TTTTT-/TCCATA`	1	--	ut3¹		5		NS	184
--	rs17115125^1,2	C	104587122(-)	`CTGCCG/AGCACC`	1	--	ut5¹ ese³		7		MN EA NS	538

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HapMap Linkage Disequilibrium images for CYP17A1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 609300 disorders: 202110 202110

UniProtKB/Swiss-Prot: CP17A_HUMAN, P05093

Defects in CYP17A1 are the cause of adrenal hyperplasia type 5 (AH5) [MIM:202110]. AH5 is

a form of congenital adrenal hyperplasia, a common recessive disease due to defective synthesis of

cortisol. Congenital adrenal hyperplasia is characterized by androgen excess leading to ambiguous

genitalia in affected females, rapid somatic growth during childhood in both sexes with premature

closure of the epiphyses and short adult stature. Four clinical types: "salt wasting" (SW, the

most severe type), "simple virilizing" (SV, less severely affected patients), with normal

aldosterone biosynthesis, "non-classic form" or late onset (NC or LOAH), and "cryptic"

(asymptomatic)

10/59 Novoseek disease relationships for CYP17A1 gene (see all 59 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
infantilism sexual	91.09	9	16483711 (1), 17379008 (1), 18832096 (1), 12701064 (1) (see all 7)
antley-bixler syndrome	79.28	1	15483095 (1)
polycystic ovary syndrome	77.44	21	19013303 (2), 15482786 (2), 7479852 (2), 10065777 (2) (see all 17)
adrenal hyperplasia congenital	76.09	12	17379008 (3), 1577471 (1), 17505056 (1), 7626447 (1) (see all 9)
adenoma adrenocortical	73.66	12	1835446 (3), 1820978 (2), 9851803 (2), 11857908 (2) (see all 7)
hyperandrogenism	72.14	14	11095477 (4), 9704303 (2), 8773744 (1), 9135692 (1) (see all 8)
pseudohermaphroditism male	67.32	2	16483711 (1), 1621662 (1)
carcinoma adrenocortical	67.27	3	11869873 (1), 16828825 (1), 18022659 (1)
polycystic ovaries	63.06	6	11821083 (2), 9648052 (1), 17895316 (1), 8923880 (1) (see all 5)
prostate cancer	60.45	117	11059764 (6), 12954495 (5), 11440959 (5), 11535545 (4) (see all 55)

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Human Gene Mutation Database: CYP17A1
Genetic Association Database: CYP17A1
Human Genome Epidemiology Navigator: CYP17A1 (204 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/704 PubMed articles for CYP17A1 gene (see all 704 ):

CYP17 polymorphisms in relation to risks of prostate cancer and benign prostatic hyperplasia: a population-based study in China. (PubMed id 12949806)^{1, 3, 6} Madigan M.P....Hsing A.W. (2003)
Increased risk of prostate cancer and benign prostatic hyperplasia associated with a CYP17 gene polymorphism with a gene dosage effect. (PubMed id 11059764)^{1, 3, 6} Habuchi T....Kato T. (2000)
A polymorphism in CYP17 and endometrial cancer risk. (PubMed id 11358812)^{1, 3, 6} Haiman C.A....De Vivo I. (2001)
CYP17 genetic polymorphism, breast cancer, and breast cancer risk factors. (PubMed id 12631398)^{1, 3, 6} Ambrosone C.B....Shields P.G. (2003)
Association of the CYP17 gene polymorphism with the risk of prostate cancer: a meta-analysis. (PubMed id 12582021)^{1, 3, 6} Ntais C....Ioannidis J.P. (2003)
Combined 17alpha-hydroxylase/17,20-lyase deficiency caused by Phe93Cys mutation in the CYP17 gene. (PubMed id 11836339)^{1, 3, 4} Di Cerbo A.... Savoia A. (2002)
The risk of breast cancer associated with dietary lignans differs by CYP17 genotype in women. (PubMed id 12368392)^{1, 3, 6} McCann S.E....Shields P.G. (2002)
The relationship between a polymorphism in CYP17 with plasma hormone levels and prostate cancer. (PubMed id 11440959)^{1, 3, 6} Haiman C.A....Hunter D.J. (2001)
Pitfalls in characterizing P450c17 mutations associated with isolated 17,20-lyase deficiency. (PubMed id 11549685)^{1, 3, 4} Gupta M.K.... Auchus R.J. (2001)
Genetic polymorphism of CYP17 and breast cancer risk in Korean women. (PubMed id 15761247)^{1, 3, 6} Shin M.H....Kang D. (2005)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 1586	HGNC: 2593	AceView: CYP17A1	Ensembl:ENSG00000148795	euGenes: HUgn1586
ECgene: CYP17A1	H-InvDB: CYP17A1

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for CYP17A1	Genetics and Cytogenetics in Oncology and Haematology
SHMPD	http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=CYP17A1
GeneReviews	http://www.genetests.org/query?gene=CYP17A1

Licensable Technologies for CYP17A1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for CYP17A1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for CYP17A1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for CYP17A1		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for CYP17A1		Small molecules for CYP17A1
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (CYP17A1)
	Antibodies (CYP17A1)
	Chimera RNAi (CYP17A1)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

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	Antibodies (Cytochrome P450 17A1)

Search OriGene for CYP17A1

Search Tocris compounds for CYP17A1

	Drugs for CYP17A1
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for CYP17A1

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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CYP17A1 Gene at Home site.
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CYP17A1 Gene

protein-coding GIFtS: 66

Aliases &
Descriptions
for CYP17A1

Summaries
for CYP17A1

Genomic Location
for CYP17A1

Proteins
for CYP17A1

Protein Domains/
Families
for CYP17A1

Gene Function
for CYP17A1

Pathways & Interactions
for CYP17A1

Drugs & Compounds
for CYP17A1

Transcripts
for CYP17A1

Expression
for CYP17A1

Orthologs
for CYP17A1

Paralogs
for CYP17A1

SNPs/Variants
for CYP17A1

Disorders & Mutations
for CYP17A1

Medical News
for CYP17A1

Publications
for CYP17A1

Search for CYP17A1

Genome Databases showing CYP17A1

Other Databases showing CYP17A1

Specialized Databases showing CYP17A1

Licensable Technologies
for CYP17A1

Services
for CYP17A1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

CYP17A1 Gene

protein-coding GIFtS: 66

Aliases & Descriptionsfor CYP17A1

Summariesfor CYP17A1

Genomic Locationfor CYP17A1

Proteinsfor CYP17A1

Protein Domains/Familiesfor CYP17A1

Gene Functionfor CYP17A1

Pathways & Interactionsfor CYP17A1

Drugs & Compoundsfor CYP17A1

Transcriptsfor CYP17A1

Expression for CYP17A1

Orthologsfor CYP17A1

Paralogsfor CYP17A1

SNPs/Variantsfor CYP17A1

Disorders & Mutationsfor CYP17A1

Medical Newsfor CYP17A1

Publicationsfor CYP17A1

Search for CYP17A1

Genome Databases showing CYP17A1

Other Databases showing CYP17A1

Specialized Databases showing CYP17A1

Licensable Technologiesfor CYP17A1

Servicesfor CYP17A1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for CYP17A1

Summaries
for CYP17A1

Genomic Location
for CYP17A1

Proteins
for CYP17A1

Protein Domains/
Families
for CYP17A1

Gene Function
for CYP17A1

Pathways & Interactions
for CYP17A1

Drugs & Compounds
for CYP17A1

Transcripts
for CYP17A1

Expression
for CYP17A1

Orthologs
for CYP17A1

Paralogs
for CYP17A1

SNPs/Variants
for CYP17A1

Disorders & Mutations
for CYP17A1

Medical News
for CYP17A1

Publications
for CYP17A1

Licensable Technologies
for CYP17A1

Services
for CYP17A1