Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



CYP11B2 Gene

protein-coding   GIFtS: 61
GCID: GC08M143988

Cytochrome P450, Family 11, Subfamily B, Polypeptide 2

(Previous names: cytochrome P450, subfamily XIB (steroid 11-beta-hydroxylase),...)
(Previous symbol: CYP11B)
  See CYP11B2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Cytochrome P450, Family 11, Subfamily B, Polypeptide 21 2     CYP11BL2
CYP11B1 2     P-450C182
Cytochrome P450, Subfamily XIB (Steroid 11-Beta-Hydroxylase), Polypeptide
21 2
     P450C182
Steroid 11-Beta-Monooxygenase1 2     P450aldo2
Aldosterone Synthase2 3     Cytochrome P450 11B2, Mitochondrial2
Aldosterone-Synthesizing Enzyme2 3     Mitochondrial Cytochrome P450, Family 11, Subfamily B, Polypeptide 22
Cytochrome P-450Aldo2 3     Steroid 11-Beta/18-Hydroxylase2
Cytochrome P-450C182 3     Steroid 18-Hydroxylase, Aldosterone Synthase, P450C18, P450aldo2
ALDOS2 3     EC 1.14.15.53
CYPXIB22 3     Steroid 18-Hydroxylase3
EC 1.14.15.43 8     EC 1.14.158
CPN22     

External Ids:    HGNC: 25921   Entrez Gene: 15852   Ensembl: ENSG000001791427   OMIM: 1240805   UniProtKB: P190993   

Export aliases for CYP11B2 gene to outside databases

Previous GC identifers: GC08U990015 GC08M144225 GC08M143796 GC08M144054 GC08M139244


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for CYP11B2 Gene:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are
monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids
and other lipids. This protein localizes to the mitochondrial inner membrane. The enzyme has steroid
18-hydroxylase activity to synthesize aldosterone and 18-oxocortisol as well as steroid 11 beta-hydroxylase
activity. Mutations in this gene cause corticosterone methyl oxidase deficiency. (provided by RefSeq, Jul 2008)

GeneCards Summary for CYP11B2 Gene:
CYP11B2 (cytochrome P450, family 11, subfamily B, polypeptide 2) is a protein-coding gene. Diseases associated with CYP11B2 include hypoaldosteronism, congenital, due to cmo ii deficiency, and hypoaldosteronism. GO annotations related to this gene include electron carrier activity and heme binding. An important paralog of this gene is CYP19A1.

UniProtKB/Swiss-Prot: C11B2_HUMAN, P19099
Function: Preferentially catalyzes the conversion of 11-deoxycorticosterone to aldosterone via corticosterone and
18-hydroxycorticosterone

Gene Wiki entry for CYP11B2 (Aldosterone synthase) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000008.10  NC_018919.2  NT_008046.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the CYP11B2 gene promoter:
         NF-1   NF-1/L   HSF1 (long)   Lmo2   Roaz   YY1   CREB   deltaCREB   HSF1short   ZID   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCYP11B2 promoter sequence
   Search Chromatin IP Primers for CYP11B2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CYP11B2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q21-q22   Ensembl cytogenetic band:  8q24.3   HGNC cytogenetic band: 8q21-q22

CYP11B2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CYP11B2 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M143988:  view genomic region     (about GC identifiers)

Start:
143,991,975 bp from pter      End:
143,999,259 bp from pter
Size:
7,285 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: C11B2_HUMAN, P19099 (See protein sequence)
Recommended Name: Cytochrome P450 11B2, mitochondrial precursor  
Size: 503 amino acids; 57560 Da
Cofactor: Heme group
2 PDB 3D structures from and Proteopedia for CYP11B2:
4DVQ (3D)        4FDH (3D)    
Secondary accessions: B0ZBE4 Q16726

Explore the universe of human proteins at neXtProt for CYP11B2: NX_P19099

Explore proteomics data for CYP11B2 at MOPED

Selected DME Specific Peptides for CYP11B2 (P19099) (see all 6)
 RQCLGRR  IPAGTLV  AGSVDTT  GVFLLNGPEW 


See CYP11B2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_000489.3  
ENSEMBL proteins: 
 ENSP00000325822  
Reactome Protein details: P19099

CYP11B2 Human Recombinant Protein Products:

Browse Purified and Recombinant Proteins at EMD Millipore
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
OriGene Protein Over-expression Lysate for CYP11B2
OriGene Custom MassSpec
OriGene Custom Protein Services for CYP11B2
GenScript Custom Purified and Recombinant Proteins Services for CYP11B2
Novus Biologicals CYP11B2 Lysate
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates
Browse ProSpec Recombinant Proteins
Browse Proteins at Cloud-Clone Corp.

 
Search eBioscience for Proteins for CYP11B2 

CYP11B2 Antibody Products:

Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse R&D Systems for Antibodies
Browse OriGene Antibodies
OriGene Custom Antibody Services for CYP11B2
Novus Biologicals CYP11B2 Antibodies
Abcam antibodies for CYP11B2
Browse Antibodies at Cloud-Clone Corp.
Search ThermoFisher Antibodies for CYP11B2
LSBio Antibodies in human, mouse, rat for CYP11B2

CYP11B2 Assay Products:

Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for CYP11B2
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for CYP11B2
Browse Enzo Life Sciences for kits & assays
Browse ELISAs at Cloud-Clone Corp.
Browse CLIAs at Cloud-Clone Corp.
Search eBioscience for ELISAs for CYP11B2 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TryGeneCards Plus
HGNC Gene Families:
CYP: Cytochrome P450s

IUPHAR Guide to PHARMACOLOGY protein family classification: CYP11B2
CYP11, CYP17, CYP19, CYP20 and CYP21 families

3 InterPro protein domains:
 IPR001128 Cyt_P450
 IPR017972 Cyt_P450_CS
 IPR002399 Cyt_P450_mitochondrial

Graphical View of Domain Structure for InterPro Entry P19099

ProtoNet protein and cluster: P19099

1 Blocks protein domain: IPB002399 Mitochondrial P450 clan signature

UniProtKB/Swiss-Prot: C11B2_HUMAN, P19099
Similarity: Belongs to the cytochrome P450 family


Find genes that share domains with CYP11B2           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Molecular Function:

     UniProtKB/Swiss-Prot Summary: C11B2_HUMAN, P19099
Function: Preferentially catalyzes the conversion of 11-deoxycorticosterone to aldosterone via corticosterone and
18-hydroxycorticosterone
Catalytic activity: A steroid + reduced adrenodoxin + O(2) = an 11-beta-hydroxysteroid + oxidized adrenodoxin +
H(2)O
Catalytic activity: Corticosterone + reduced adrenodoxin + O(2) = 18-hydroxycorticosterone + oxidized adrenodoxin
+ H(2)O

     Genatlas biochemistry entry for CYP11B2:
cytochrome p450,subfamily XIB,multifunctional enzyme with 18 hydroxylase,18 hydroxysteroid dehydrogenase and
accessorily 11 beta-hydroxylase activity,mitochondrial,involved in mineralocorticoid biosynthesis,stimulated by
angiotensin II and potassium,expressed in zona glomerulosa of the adrenal cortex

     Enzyme Numbers (IUBMB): EC 1.14.15.41 2 EC 1.14.152 EC 1.14.15.51

     Gene Ontology (GO): 5 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004507steroid 11-beta-monooxygenase activity IDA1741400
GO:0005506iron ion binding IEA--
GO:0016705oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen ----
GO:0020037heme binding IDA--
GO:0047783corticosterone 18-monooxygenase activity IEA--
     
Find genes that share ontologies with CYP11B2           About GenesLikeMe


Phenotypes:
     9 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Cyp11b2):
 behavior/neurological  cardiovascular system  cellular  endocrine/exocrine gland  growth/size/body 
 homeostasis/metabolism  mortality/aging  muscle  renal/urinary system 

Find genes that share phenotypes with CYP11B2           About GenesLikeMe

Animal Models:
     MGI mouse knock-out Cyp11b2tm1Hsk for CYP11B2

   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CYP11B2
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CYP11B2

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CYP11B2
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CYP11B2

miRNA
Products:
    
miRTarBase miRNAs that target CYP11B2:
hsa-mir-26b-5p (MIRT029873)

Block miRNA regulation of human, mouse, rat CYP11B2 using miScript Target Protectors
Search for qRT-PCR Assays for microRNAs that regulate CYP11B2
SwitchGear 3'UTR luciferase reporter plasmidCYP11B2 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for CYP11B2
Predesigned siRNA for gene silencing in human, mouse, rat CYP11B2

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for CYP11B2

Clone
Products:
     
OriGene clones in human, mouse for CYP11B2 (see all 6)
OriGene ORF clones in mouse, rat for CYP11B2
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: CYP11B2 (NM_000498)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for CYP11B2
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CYP11B2

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for CYP11B2
Browse ESI BIO Cell Lines and PureStem Progenitors for CYP11B2 
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYP11B2

Flow Cytometry
Products:
   

 
eBioscience FlowRNA Probe Sets ( VA1-13546) for CYP11B2 


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Subcellular locations from UniProtKB/Swiss-Prot
C11B2_HUMAN, P19099: Mitochondrion membrane
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
mitochondrion5
cytosol2
extracellular2
nucleus2

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005739mitochondrion IDA1741400
GO:0005743mitochondrial inner membrane TAS--

Find genes that share ontologies with CYP11B2           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
About This Section

TryGeneCards Plus

SuperPaths for CYP11B2 About   (see all 7)  
See pathways by source

SuperPathContained pathways About
1Cytochrome P450 - arranged by substrate type
Cytochrome P450 - arranged by substrate type0.75
cytochrome P4500.74
Phase 1 - Functionalization of compounds0.75
Endogenous sterols0.00
2Metabolism of steroid hormones and vitamin D
Mineralocorticoid biosynthesis0.00
mineralocorticoid biosynthesis0.00
Metabolism of steroid hormones and vitamin D
Glucocorticoid biosynthesis0.00
3Metabolism
Metabolism0.38
Metabolism of lipids and lipoproteins0.37
Metabolic pathways0.38
4Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics
Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics0.37
ACE Inhibitor Pathway0.00
ACE Inhibitor Pathway, Pharmacodynamics0.00
5Biological oxidations
Biological oxidations0.56
metapathway biotransformation0.42


Find genes that share SuperPaths with CYP11B2           About GenesLikeMe

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


Selected BioSystems Pathways for CYP11B2 (see all 6)
    ACE Inhibitor Pathway
cytochrome P450
mineralocorticoid biosynthesis
superpathway of steroid hormone biosynthesis
metapathway biotransformation

3 Reactome Pathways for CYP11B2
    Endogenous sterols
Mineralocorticoid biosynthesis
Glucocorticoid biosynthesis

2 PharmGKB Pathways for CYP11B2
    ACE Inhibitor Pathway, Pharmacodynamics
Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics

2 Kegg Pathways  (Kegg details for CYP11B2):
    Steroid hormone biosynthesis
Metabolic pathways

    Pathway & Disease-focused RT2 Profiler PCR Arrays including CYP11B2: 
          Drug Metabolism: Phase I Enzymes in human mouse rat
          Cellular Stress Responses in human mouse rat
          Drug Metabolism in human mouse rat

Interactions:

    GeneGlobe Interaction Network for CYP11B2

STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

Selected Interacting proteins for CYP11B2 (P190993 ENSP000003258224) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
InteractantInteraction Details
GeneCardExternal ID(s)
CYP11B1P155383, ENSP000002924274I2D: score=1 STRING: ENSP00000292427
FDX1P101093, ENSP000002602704I2D: score=1 STRING: ENSP00000260270
CYP11A1P051083, ENSP000002680534I2D: score=1 STRING: ENSP00000268053
AKR1D1ENSP000002423754STRING: ENSP00000242375
ENSG00000232414ENSP000004165984STRING: ENSP00000416598
About this table

Gene Ontology (GO): Selected biological process terms (see all 15):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0002017regulation of blood volume by renal aldosterone IMP14614232
GO:0003091renal water homeostasis IC2256920
GO:0006700C21-steroid hormone biosynthetic process IDA2256920
GO:0006705mineralocorticoid biosynthetic process TAS--
GO:0006805xenobiotic metabolic process TAS--

Find genes that share ontologies with CYP11B2           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
About This Section

TryGeneCards Plus
Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for CYP11B2 (C11B2)

Selected HMDB Compounds for CYP11B2 (see all 22)    About this table
CompoundSynonyms CAS #PubMed Ids
11b,17a,21-Trihydroxypreg-nenolone11beta,17alpha,21-Trihydroxypregnenolone (see all 2)----
11b-Hydroxyandrost-4-ene-3,17-dioneAndrost-4-ene-3,17-dione-11beta-ol (see all 3)382-44-5--
11b-Hydroxyprogesterone11b-Hydroxyprogesterone (see all 7)600-57-7--
11beta-Hydroxyprogesterone ----
17-Hydroxyprogesterone17-OHP (see all 15)68-96-2--
17a,21-Dihydroxypreg-nenolone17alpha,21-Dihydroxypregnenolone (see all 2)1167-48-2--
18-Hydroxycorticosterone11b,18,21-trihydroxy-pregn-4-ene-3,20-dione (see all 2)561-65-9--
19-Hydroxydeoxycorticosterone11-deoxy-19-hydroxycorticosterone;11-desoxy-19-hydroxycorticosterone;19,21-dihydroxy-4-pregnene-3,20-dione;19,21-dihydroxypregn-4-ene-3,20-dione;19-Hydroxy-11-deoxycorticosterone;19-Hydroxy-11-desoxycorticosterone 2394-23-2--
19-Oxo-deoxycorticosterone21-hydroxy-19-oxopregn-4-ene-3,20-dione 75220-37-0--
19-oic-deoxycorticosterone21-hydroxy-3,20-dioxopregn-4-en-19-oic acid anion (see all 3)81309-33-3--

7 DrugBank Compounds for CYP11B2    About this table
CompoundSynonyms CAS #TypeActionsPubMed Ids
MetyraponeMepyrapone (see all 9)54-36-4enzymeinhibitor9231789 17646925
Aldosterone(+)-aldosterone (see all 18)52-39-1enzymesubstrate19934256
Eplerenone-- 107724-20-9enzymeinhibitor19934256
Etomidate-- 33125-97-2enzymeinhibitor19934256
Hydrocortisone11beta-Hydroxycortisone (see all 16)50-23-7enzymesubstrate19934256
MetoclopramideMetaclopramide (see all 9)364-62-5enzymeinducer19934256
Mibefradil-- 116644-53-2enzymeinhibitor19934256

Selected Novoseek inferred chemical compound relationships for CYP11B2 gene (see all 63)    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
18-hydroxycortisol 91.6 4 15062555 (2), 9814482 (1), 18505761 (1)
18-hydroxycorticosterone 91.2 21 11549669 (2), 7852500 (1), 2256920 (1), 10411633 (1) (see all 9)
18-oxocortisol 90.9 5 9814482 (1), 17381495 (1), 18505761 (1), 1741400 (1)
doca 89.6 28 1775135 (2), 11549669 (2), 8077359 (1), 7852500 (1) (see all 21)
tetrahydroaldosterone 88.1 1 19151144 (1)
11 deoxycortisol 86.3 6 9814482 (1), 10559665 (1), 9698019 (1), 15522937 (1) (see all 6)
18-hydroxydeoxycorticosterone 76.7 4 11549669 (3)
corticosterone 74.8 34 7852500 (2), 11275950 (2), 8077359 (1), 15947886 (1) (see all 22)
fludrocortisone 72.5 1 15782303 (1)
tetrahydro-11-deoxycortisol 71.8 1 15134824 (1)

3 PharmGKB related drug/compound annotations for CYP11B2 gene    About this table
Drug/compound PharmGKB Annotation
benazeprilCA  
candesartanCA  
imidaprilCA  



Find genes that share compounds with CYP11B2           About GenesLikeMe



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
About This Section

TryGeneCards Plus

REFSEQ mRNAs for CYP11B2 gene: 
NM_000498.3  

Unigene Cluster for CYP11B2:

Cytochrome P450, family 11, subfamily B, polypeptide 2
Hs.632054  [show with all ESTs]
Unigene Representative Sequence: NM_000498
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000323110(uc003yxk.1)
miRNA
Products:
     
Block miRNA regulation of human, mouse, rat CYP11B2 using miScript Target Protectors
Search for qRT-PCR Assays for microRNAs that regulate CYP11B2
SwitchGear 3'UTR luciferase reporter plasmidCYP11B2 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for CYP11B2
Predesigned siRNA for gene silencing in human, mouse, rat CYP11B2
Clone
Products:
     
OriGene clones in human, mouse for CYP11B2 (see all 6)
OriGene ORF clones in mouse, rat for CYP11B2
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: CYP11B2 (NM_000498)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for CYP11B2
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CYP11B2
Primer
Products:
    
OriGene qSTAR qPCR primer pairs in human, mouse for CYP11B2
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CYP11B2
  QuantiTect SYBR Green Assays in human, mouse, rat CYP11B2
  QuantiFast Probe-based Assays in human, mouse, rat CYP11B2
Flow Cytometry
Products:
   

 
eBioscience FlowRNA Probe Sets ( VA1-13546) for CYP11B2 

Additional mRNA sequence: X54741.1 

1 DOTS entry:

DT.95080617 

10 AceView cDNA sequences:

BV199117 T28774 BV183624 BV198798 BV198800 NM_000498 X54741 BV195495 
AV710391 BF791620 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TryGeneCards Plus

CYP11B2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GGAAAGGAAT
CYP11B2 Expression
About this image

CYP11B2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

CYP11B2 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.632054
    Pathway & Disease-focused RT2 Profiler PCR Arrays including CYP11B2: 
          Drug Metabolism: Phase I Enzymes in human mouse rat
          Cellular Stress Responses in human mouse rat
          Drug Metabolism in human mouse rat

Primer
Products:
OriGene qSTAR qPCR primer pairs in human, mouse for CYP11B2
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CYP11B2
QuantiTect SYBR Green Assays in human, mouse, rat CYP11B2
QuantiFast Probe-based Assays in human, mouse, rat CYP11B2
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYP11B2

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

TryGeneCards Plus

This gene was present in the common ancestor of animals.

Orthologs for CYP11B2 gene from Selected species (see all 12)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Cyp11b25
Cyp11b11
cytochrome P450, family 11, subfamily b, polypeptide 2 less5
cytochrome P450, family 11, subfamily b, polypeptide 1 less1
73.48(n)1
64.93(a)1
  15 (34.29 cM)5
1101151  NM_001033229.31  NP_001028401.21 
 748510105 
lizard
(Anolis carolinensis)
Reptilia --
Uncharacterized protein
50(a)
1 → many
AAWZ02036987(3866-16154)
zebrafish
(Danio rerio)
Actinopterygii cyp11c16
cytochrome P450, family 11, subfamily C, polypepti...
33(a)
1 → many
16(57904611-57917200) ENSDARG00000042014
fruit fly
(Drosophila melanogaster)
Insecta Cyp12c13 cytochrome P450 31(a)
(best of 2)
  75D6   --
worm
(Caenorhabditis elegans)
Secernentea ccp-443 cytochrome p450 27(a)   II(5504020-5505870)   --


ENSEMBL Gene Tree for CYP11B2 (if available)
TreeFam Gene Tree for CYP11B2 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section

TryGeneCards Plus
Paralogs for CYP11B2 gene
CYP19A12  CYP11B12  CYP24A12  CYP46A12  CYP27B12  CYP11A12  CYP27A12  CYP27C12  
5 SIMAP similar genes for CYP11B2 using alignment to 3 protein entries:     C11B2_HUMAN (see all proteins):
CYP11B1    CYP11A1    CYP27B1    CYP27C1    CYP24A1

Find genes that share paralogs with CYP11B2           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

TryGeneCards Plus

Selected SNPs for CYP11B2 (see all 470)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 8 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
VAR_0012684
Corticosterone methyloxidase 2 deficiency (CMO-2 deficiency)4--see VAR_0012682 E D mis40--------
VAR_0184724
Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency)4--see VAR_0184722 L P mis40--------
rs45411,2,4
Corticosterone methyloxidase 2 deficiency (CMO-2 deficiency)4--see VAR_0012692 mis40--------
VAR_0184734
Corticosterone methyloxidase 2 deficiency (CMO-2 deficiency)4--see VAR_0184732 T A mis40--------
VAR_0184714
Corticosterone methyloxidase 2 deficiency (CMO-2 deficiency)4--see VAR_0184712 T I mis40--------
rs725546261,2
Cpathogenic1144267999(-) TCCTCA/GCTTTC 2 T A mis10--------
rs725546271,2
Cpathogenic1144268545(-) GATGCC/TGCTGC 2 P L mis10--------
rs617572941,2
C,Fpathogenic1144268849(+) AGCTCA/GCCACT 2 A V mis15Minor allele frequency- G:0.06NS CSA NA EU 6074
rs1219129771,2
Cpathogenic1144270740(-) GGAAGG/TAGCAC 2 E * stg11Minor allele frequency- T:0.00NA 4516
rs1048940721,2
Cpathogenic1144271046(-) ATAGAA/CGGTGT 2 E D mis10--------

HapMap Linkage Disequilibrium report for CYP11B2 (143991975 - 143999259 bp)

Structural Variations
     Database of Genomic Variants (DGV) 7 variations for CYP11B2:    About this table    
Variant IDTypeSubtypePubMed ID
esv2673440CNV Deletion23128226
esv991235CNV Deletion20482838
esv2737938CNV Deletion23290073
nsv436586CNV Deletion17901297
esv2661137CNV Deletion23128226
nsv891648CNV Loss21882294
nsv470246CNV Loss18288195

Human Gene Mutation Database (HGMD): CYP11B2
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing CYP11B2
DNA2.0 Custom Variant and Variant Library Synthesis for CYP11B2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TryGeneCards Plus
OMIM gene information: 124080   
OMIM disorders: 610600  203400  
UniProtKB/Swiss-Prot: C11B2_HUMAN, P19099
  • Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency) [MIM:203400]: Autosomal recessive disorder
    of aldosterone biosynthesis. There are two biochemically different forms of selective aldosterone deficiency be
    termed corticosterone methyloxidase (CMO) deficiency type 1 and type 2. In CMO-1 deficiency, aldosterone is
    undetectable in plasma, while its immediate precursor, 18-hydroxycorticosterone, is low or normal. Note=The
    disease is caused by mutations affecting the gene represented in this entry
  • Corticosterone methyloxidase 2 deficiency (CMO-2 deficiency) [MIM:610600]: Autosomal recessive disorder
    of aldosterone biosynthesis. In CMO-2 deficiency, aldosterone can be low or normal, but at the expense of
    increased secretion of 18-hydroxycorticosterone. Consequently, patients have a greatly increased ratio of
    18-hydroxycorticosterone to aldosterone and a low ratio of corticosterone to 18-hydroxycorticosterone in serum.
    Note=The disease is caused by mutations affecting the gene represented in this entry
  • Familial hyperaldosteronism 1 (FH1) [MIM:103900]: A disorder characterized by hypertension, variable
    hyperaldosteronism, and abnormal adrenal steroid production, including 18-oxocortisol and 18-hydroxycortisol.
    There is significant phenotypic heterogeneity, and some individuals never develop hypertension. Note=The disease
    is caused by mutations affecting the gene represented in this entry. The molecular defect causing
    hyperaldosteronism familial 1 is an anti-Lepore-type fusion of the CYP11B1 and CYP11B2 genes. The hybrid gene has
    the promoting part of CYP11B1, ACTH-sensitive, and the coding part of CYP11B2

  • Selected diseases for CYP11B2 (see all 22):    
    About MalaCards
    hypoaldosteronism, congenital, due to cmo ii deficiency    hypoaldosteronism    corticosterone methyloxidase type ii deficiency    hypoaldosteronism, congenital, due to cmo i deficiency
    low renin hypertension    corticosterone methyloxidase deficiency    18 hydroxylase deficiency    aldosterone to renin ratio raised
    aortic coarctation    glucocorticoid-remediable aldosteronism    conn's syndrome    pulmonary edema
    kabuki syndrome 1    hyperaldosteronism    familial hyperaldosteronism    adrenal adenoma
    kabuki syndrome    systolic heart failure    adrenocortical carcinoma    congenital adrenal hyperplasia

    7 diseases from the University of Copenhagen DISEASES database for CYP11B2:
    Hyperaldosteronism     Conn's syndrome     Hypertension     Adenoma
    Hypokalemia     Adrenocortical carcinoma     Cushing's syndrome

    Find genes that share disorders with CYP11B2           About GenesLikeMe

    Selected Novoseek inferred disease relationships for CYP11B2 gene (see all 42)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glucocorticoid-remediable aldosteronism 93.7 15 11600544 (2), 18505761 (1), 8954032 (1), 10843166 (1) (see all 10)
    cmo i deficiency 92.8 4 7852500 (1), 8439335 (1), 9177280 (1)
    hyperaldosteronism 90 21 10914997 (2), 15062555 (1), 18505761 (1), 9745430 (1) (see all 16)
    hypoaldosteronism 88.5 21 11701710 (3), 11422109 (2), 16733366 (2), 7852500 (1) (see all 10)
    aldosteronism primary 88 25 2256920 (2), 20339375 (2), 12608705 (2), 11422106 (2) (see all 16)
    essential hypertension 78.3 42 15505931 (3), 12444540 (2), 12817181 (2), 16126185 (2) (see all 28)
    low renin hypertension 73.5 2 11587161 (1), 8784078 (1)
    adrenal hyperplasia congenital 71.1 5 11443188 (1), 11549691 (1), 15134805 (1), 9300202 (1)
    adrenal hyperplasia 67.4 3 7758082 (1), 11443188 (1), 15248825 (1)
    myocardial fibrosis 65.1 12 11914098 (2), 16220979 (2), 16246562 (1), 16570918 (1) (see all 5)

    Genetic Association Database (GAD): CYP11B2
    Human Genome Epidemiology (HuGE) Navigator: CYP11B2 (189 documents)

    Export disorders for CYP11B2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for CYP11B2 gene, integrated from 10 sources (see all 522):
    (articles sorted by number of sources associating them with CYP11B2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Haplotypes of aldosterone synthase (CYP11B2) gene in the general population of Japan: the Ohasama study. (PubMed id 11728005)1, 4, 9 Matsubara M....Imai Y. (Clin. Exp. Hypertens. 2001)
    2. Mutation analysis of CYP11B1 and CYP11B2 in patients with increased 18-hydroxycortisol production. (PubMed id 15062555)1, 4, 9 Nicod J....Ferrari P. (Mol. Cell. Endocrinol. 2004)
    3. Congenitally defective aldosterone biosynthesis in humans: inactivation of the P-450(C18) gene (CYP11B2) due to nucleotide deletion in CMO I deficient patients. (PubMed id 8439335)1, 2, 9 Mitsuuchi Y.... Shizuta Y. (Biochem. Biophys. Res. Commun. 1993)
    4. [Impact of gene-environment interaction between the C (-344) T polymorphism of CYP11B2 and drinking index on the risk of hypertension under multifactor dimensionality reduction model in Chinese Mongolian population]. (PubMed id 20193236)1, 4, 9 Pan X.Q....Tong W.J. (Zhonghua Liu Xing Bing Xue Za Zhi 2009)
    5. Multiple Polymorphisms in the renin- angiotensin-aldosterone system (ACE, CYP11B2, AGTR1) and their contribution to hypertension in African Americans and Latinos in the multiethnic cohort. (PubMed id 15545843)1, 4, 9 Henderson S.O....Mack W. (Am. J. Med. Sci. 2004)
    6. CYP11B2 polymorphisms and home blood pressure in a population-based cohort in Japanese: the Ohasama study. (PubMed id 15055249)1, 4, 9 Matsubara M....Imai Y. (Hypertens. Res. 2004)
    7. The -344T&gt;C promoter variant of the gene for aldosterone synthase (CYP11B2) is not associated with cardiovascular risk in a prospective study of UK healthy men. (PubMed id 15135254)1, 4, 9 Payne J.R....Montgomery H.E. (Atherosclerosis 2004)
    8. [Associations of the genetic polymorphisms in CYP11B2 gene with nonfamilial structural atrial fibrillation]. (PubMed id 20193392)1, 4, 9 Cao F.F....Jin L. (Zhonghua Liu Xing Bing Xue Za Zhi 2009)
    9. Effect of variation in CYP11B1 and CYP11B2 on corticosteroid phenotype and hypothalamic-pituitary-adrenal axis activity in hypertensive and normotensive subjects. (PubMed id 17980006)1, 4, 9 Freel E.M....Connell J.M. (Clin. Endocrinol. (Oxf) 2008)
    10. Association of the C-344T polymorphism of CYP11B2 gene with essential hypertension in Hani and Yi minorities of China. (PubMed id 16126185)1, 4, 9 Tang W....Xiao C. ( international journal of clinical chemistry 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 1585 HGNC: 2592 AceView: CYP11B2 Ensembl:ENSG00000179142 euGenes: HUgn1585
    ECgene: CYP11B2 Kegg: 1585 H-InvDB: CYP11B2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for CYP11B2 Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=CYP11B2[genesymbol]
    Wikipedia http://en.wikipedia.org/wiki/CYP11B2

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for CYP11B2 gene:
    Search GeneIP for patents involving CYP11B2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for CYP11B2  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for CYP11B2  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for CYP11B2  
     OriGene qSTAR qPCR primer pairs in human, mouse for CYP11B2   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for CYP11B2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CYP11B2   OriGene Custom Protein Services for CYP11B2  

     
     
     Block miRNA regulation of human, mouse, rat CYP11B2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing CYP11B2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CYP11B2 Predesigned siRNA for gene silencing in human, mouse, rat CYP11B2
     QuantiFast Probe-based Assays in human, mouse, rat CYP11B2 QuantiTect SYBR Green Assays in human, mouse, rat CYP11B2
     PCR Arrays including human, mouse, rat CYP11B2 Search Chromatin IP Primers for CYP11B2
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CYP11B2  GeneGlobe Interaction Network for CYP11B2
     Regulatory tfbs in CYP11B2 promoter
     GenScript Custom Purified and Recombinant Proteins Services for CYP11B2 GenScript cDNA clones with any tag delivered in your preferred vector for CYP11B2
     GenScript Custom Assay Services for CYP11B2 GenScript Custom overexpressing Cell Line Services for CYP11B2
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for CYP11B2 (C11B2)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     CYP11B2 antibodies
     CYP11B2 lysates
     Antibodies for CYP11B2
     See all of Abcam's Antibodies, Kits and Proteins for CYP11B2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for CYP11B2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYP11B2
     SwitchGear 3'UTR luciferase reporter plasmids for CYP11B2
     SwitchGear Promoter luciferase reporter plasmids for CYP11B2
     Search ThermoFisher Antibodies for CYP11B2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CYP11B2
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CYP11B2
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CYP11B2
     LSBio Antibodies in human, mouse, rat for CYP11B2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for CYP11B2
      Search eBioscience for proteins for CYP11B2
      Search eBioscience for elisas for CYP11B2
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CYP11B2 gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4