Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CYP11B2 Gene

protein-coding   GIFtS: 63
GCID: GC08M143988

Cytochrome P450, Family 11, Subfamily B, Polypeptide 2

(Previous names: cytochrome P450, subfamily XIB (steroid 11-beta-hydroxylase),...)
(Previous symbol: CYP11B)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Cytochrome P450, Family 11, Subfamily B, Polypeptide 21 2     CYP11BL2
CYP11B1 2     P-450C182
Cytochrome P450, Subfamily XIB (Steroid 11-Beta-Hydroxylase), Polypeptide
21 2
     P450C182
Steroid 11-Beta-Monooxygenase1 2     P450aldo2
Aldosterone Synthase2 3     Cytochrome P450 11B2, Mitochondrial2
Aldosterone-Synthesizing Enzyme2 3     Mitochondrial Cytochrome P450, Family 11, Subfamily B, Polypeptide 22
Cytochrome P-450Aldo2 3     Steroid 11-Beta/18-Hydroxylase2
Cytochrome P-450C182 3     Steroid 18-Hydroxylase, Aldosterone Synthase, P450C18, P450aldo2
ALDOS2 3     EC 1.14.15.53
CYPXIB22 3     Steroid 18-Hydroxylase3
EC 1.14.15.43 8     EC 1.14.158
CPN22     

External Ids:    HGNC: 25921   Entrez Gene: 15852   Ensembl: ENSG000001791427   OMIM: 1240805   UniProtKB: P190993   

Export aliases for CYP11B2 gene to outside databases

Previous GC identifers: GC08U990015 GC08M144225 GC08M143796 GC08M144054 GC08M139244


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CYP11B2 Gene:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are
monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids
and other lipids. This protein localizes to the mitochondrial inner membrane. The enzyme has steroid
18-hydroxylase activity to synthesize aldosterone and 18-oxocortisol as well as steroid 11 beta-hydroxylase
activity. Mutations in this gene cause corticosterone methyl oxidase deficiency. (provided by RefSeq, Jul 2008)

GeneCards Summary for CYP11B2 Gene: 
CYP11B2 (cytochrome P450, family 11, subfamily B, polypeptide 2) is a protein-coding gene. Diseases associated with CYP11B2 include glucocorticoid-remediable aldosteronism, and hypoaldosteronism, and among its related super-pathways are Glucocorticoid biosynthesis and ACE Inhibitor Pathway. GO annotations related to this gene include electron carrier activity and heme binding. An important paralog of this gene is CYP11A1.

UniProtKB/Swiss-Prot: C11B2_HUMAN, P19099
Function: Preferentially catalyzes the conversion of 11-deoxycorticosterone to aldosterone via corticosterone and
18-hydroxycorticosterone

Gene Wiki entry for CYP11B2 (Aldosterone synthase) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.2  NT_008046.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CYP11B2 gene promoter:
         NF-1   NF-1/L   HSF1 (long)   Lmo2   Roaz   YY1   CREB   deltaCREB   HSF1short   ZID   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCYP11B2 promoter sequence
   Search SABiosciences Chromatin IP Primers for CYP11B2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CYP11B2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q21-q22   Ensembl cytogenetic band:  8q24.3   HGNC cytogenetic band: 8q21-q22

CYP11B2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CYP11B2 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M143988:  view genomic region     (about GC identifiers)

Start:
143,991,975 bp from pter      End:
143,999,259 bp from pter
Size:
7,285 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: C11B2_HUMAN, P19099 (See protein sequence)
Recommended Name: Cytochrome P450 11B2, mitochondrial precursor  
Size: 503 amino acids; 57560 Da
Cofactor: Heme group
Subcellular location: Mitochondrion membrane
2 PDB 3D structures from and Proteopedia for CYP11B2:
4DVQ (3D)        4FDH (3D)    
Secondary accessions: B0ZBE4 Q16726

Explore the universe of human proteins at neXtProt for CYP11B2: NX_P19099

Explore proteomics data for CYP11B2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P19099

  • 4/6 DME Specific Peptides for CYP11B2 (P19099) (see all 6)
     RQCLGRR  IPAGTLV  AGSVDTT  GVFLLNGPEW 

    CYP11B2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CYP11B2 Protein Expression
    REFSEQ proteins: NP_000489.3  
    ENSEMBL proteins: 
     ENSP00000325822  
    Reactome Protein details: P19099
    Human Recombinant Protein Products for CYP11B2: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for CYP11B2
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for CYP11B2
    GenScript Custom Purified and Recombinant Proteins Services for CYP11B2
    Novus Biologicals CYP11B2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IDA1741400
    GO:0005743mitochondrial inner membrane TAS--

    CYP11B2 for ontologies           About GeneDecksing



    CYP11B2 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for CYP11B2
    GenScript Custom Superior Antibodies Services for CYP11B2
    Novus Biologicals CYP11B2 Antibodies
    Abcam antibodies for CYP11B2
    Browse Antibodies at Cloud-Clone Corp. 
    Search ThermoFisher Antibodies for CYP11B2
    LSBio Antibodies in human, mouse, rat for CYP11B2 

    Assay Products for CYP11B2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CYP11B2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CYP11B2
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CYP: Cytochrome P450s

    IUPHAR Guide to PHARMACOLOGY protein family classification: CYP11B2 
    CYP11, CYP17, CYP19, CYP20 and CYP21 families

    3 InterPro protein domains:
     IPR001128 Cyt_P450
     IPR017972 Cyt_P450_CS
     IPR002399 Cyt_P450_mitochondrial

    Graphical View of Domain Structure for InterPro Entry P19099

    ProtoNet protein and cluster: P19099

    1 Blocks protein domain: IPB002399 Mitochondrial P450 clan signature

    UniProtKB/Swiss-Prot: C11B2_HUMAN, P19099
    Similarity: Belongs to the cytochrome P450 family


    CYP11B2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: C11B2_HUMAN, P19099
    Function: Preferentially catalyzes the conversion of 11-deoxycorticosterone to aldosterone via corticosterone and
    18-hydroxycorticosterone
    Catalytic activity: A steroid + reduced adrenodoxin + O(2) = an 11-beta-hydroxysteroid + oxidized adrenodoxin +
    H(2)O
    Catalytic activity: Corticosterone + reduced adrenodoxin + O(2) = 18-hydroxycorticosterone + oxidized adrenodoxin
    + H(2)O

         Genatlas biochemistry entry for CYP11B2:
    cytochrome p450,subfamily XIB,multifunctional enzyme with 18 hydroxylase,18 hydroxysteroid dehydrogenase and
    accessorily 11 beta-hydroxylase activity,mitochondrial,involved in mineralocorticoid biosynthesis,stimulated by
    angiotensin II and potassium,expressed in zona glomerulosa of the adrenal cortex

         Enzyme Numbers (IUBMB): EC 1.14.15.41 2 EC 1.14.152 EC 1.14.15.51

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004507steroid 11-beta-monooxygenase activity IDA1741400
    GO:0005506iron ion binding IEA--
    GO:0009055electron carrier activity IEA--
    GO:0016705oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen ----
    GO:0020037heme binding IDA--
         
    CYP11B2 for ontologies           About GeneDecksing


    Phenotypes:
         9 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Cyp11b2):
     behavior/neurological  cardiovascular system  cellular  endocrine/exocrine gland  growth/size 
     homeostasis/metabolism  mortality/aging  muscle  renal/urinary system 

    CYP11B2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Cyp11b2tm1Hsk for CYP11B2

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CYP11B2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CYP11B2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CYP11B2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CYP11B2 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CYP11B2
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate CYP11B2
    SwitchGear 3'UTR luciferase reporter plasmidCYP11B2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CYP11B2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CYP11B2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CYP11B2
    Sirion Biotech Customized adenovirus for overexpression of CYP11B2

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for CYP11B2 (see all 7)
    OriGene ORF clones in mouse, rat for CYP11B2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CYP11B2 (NM_000498)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CYP11B2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CYP11B2
    Sirion Biotech Customized lentivirus for stable overexpression of CYP11B2 
                         Customized lentivirus expression plasmids for stable overexpression of CYP11B2 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CYP11B2
    Search LifeMap BioReagents cell lines for CYP11B2
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYP11B2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CYP11B2 About   (see all 8)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Mineralocorticoid biosynthesis
    Mineralocorticoid biosynthesis0.71
    Glucocorticoid & Mineralcorticoid Metabolism0.67
    Glucocorticoid biosynthesis0.71
    mineralocorticoid biosynthesis0.60
    2Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics
    ACE Inhibitor Pathway0.85
    ACE Inhibitor Pathway, Pharmacodynamics0.85
    Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics0.85
    3Cytochrome P450 - arranged by substrate type
    Cytochrome P450 - arranged by substrate type0.75
    Phase 1 - Functionalization of compounds0.74
    cytochrome P4500.75
    4Metabolism
    Metabolism0.40
    Metabolism of lipids and lipoproteins0.34
    Metabolic pathways0.40
    5Biological oxidations
    Biological oxidations0.55
    metapathway biotransformation0.41

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5 BioSystems Pathways for CYP11B2
        cytochrome P450
    ACE Inhibitor Pathway
    mineralocorticoid biosynthesis
    metapathway biotransformation
    Glucocorticoid & Mineralcorticoid Metabolism

    5/10        Reactome Pathways for CYP11B2 (see all 10)
        Cytochrome P450 - arranged by substrate type
    Mineralocorticoid biosynthesis
    Metabolism
    Steroid hormones
    Endogenous sterols

    2 PharmGKB Pathways for CYP11B2
        ACE Inhibitor Pathway, Pharmacodynamics
    Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics

    2         Kegg Pathways  (Kegg details for CYP11B2):
        Steroid hormone biosynthesis
    Metabolic pathways


    CYP11B2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CYP11B2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/7 Interacting proteins for CYP11B2 (P190993 ENSP000003258224) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CYP11B1P155383, ENSP000002924274I2D: score=1 STRING: ENSP00000292427
    FDX1P101093, ENSP000002602704I2D: score=1 STRING: ENSP00000260270
    CYP11A1P051083, ENSP000002680534I2D: score=1 STRING: ENSP00000268053
    AKR1D1ENSP000002423754STRING: ENSP00000242375
    ENSG00000232414ENSP000004165984STRING: ENSP00000416598
    About this table

    Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002017regulation of blood volume by renal aldosterone IMP14614232
    GO:0003091renal water homeostasis IC2256920
    GO:0006700C21-steroid hormone biosynthetic process IDA2256920
    GO:0006705mineralocorticoid biosynthetic process TAS--
    GO:0006805xenobiotic metabolic process TAS--

    CYP11B2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CYP11B2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CYP11B2 (C11B2)

    10/22 HMDB Compounds for CYP11B2 (see all 22)    About this table
    CompoundSynonyms CAS #PubMed Ids
    11b,17a,21-Trihydroxypreg-nenolone11beta,17alpha,21-Trihydroxypregnenolone (see all 2)----
    11b-Hydroxyandrost-4-ene-3,17-dioneAndrost-4-ene-3,17-dione-11beta-ol (see all 3)382-44-5--
    11b-Hydroxyprogesterone11b-Hydroxyprogesterone (see all 7)600-57-7--
    11beta-Hydroxyprogesterone ----
    17-Hydroxyprogesterone17-OHP (see all 15)68-96-2--
    17a,21-Dihydroxypreg-nenolone17alpha,21-Dihydroxypregnenolone (see all 2)1167-48-2--
    18-Hydroxycorticosterone11b,18,21-trihydroxy-pregn-4-ene-3,20-dione (see all 2)561-65-9--
    19-Hydroxydeoxycorticosterone11-deoxy-19-hydroxycorticosterone;11-desoxy-19-hydroxycorticosterone;19,21-dihydroxy-4-pregnene-3,20-dione;19,21-dihydroxypregn-4-ene-3,20-dione;19-Hydroxy-11-deoxycorticosterone;19-Hydroxy-11-desoxycorticosterone 2394-23-2--
    19-Oxo-deoxycorticosterone21-hydroxy-19-oxopregn-4-ene-3,20-dione 75220-37-0--
    19-oic-deoxycorticosterone21-hydroxy-3,20-dioxopregn-4-en-19-oic acid anion (see all 3)81309-33-3--

    7 DrugBank Compounds for CYP11B2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    MetyraponeMepyrapone (see all 9)54-36-4enzymeinhibitor9231789 17646925
    Aldosterone(+)-aldosterone (see all 18)52-39-1enzymesubstrate19934256
    Eplerenone-- 107724-20-9enzymeinhibitor19934256
    Etomidate-- 33125-97-2enzymeinhibitor19934256
    Hydrocortisone11beta-Hydroxycortisone (see all 16)50-23-7enzymesubstrate19934256
    MetoclopramideMetaclopramide (see all 9)364-62-5enzymeinducer19934256
    Mibefradil-- 116644-53-2enzymeinhibitor19934256

    10/63 Novoseek inferred chemical compound relationships for CYP11B2 gene (see all 63)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    18-hydroxycortisol 91.6 4 15062555 (2), 9814482 (1), 18505761 (1)
    18-hydroxycorticosterone 91.2 21 11549669 (2), 7852500 (1), 2256920 (1), 10411633 (1) (see all 9)
    18-oxocortisol 90.9 5 9814482 (1), 17381495 (1), 18505761 (1), 1741400 (1)
    doca 89.6 28 1775135 (2), 11549669 (2), 8077359 (1), 7852500 (1) (see all 21)
    tetrahydroaldosterone 88.1 1 19151144 (1)
    11 deoxycortisol 86.3 6 9814482 (1), 10559665 (1), 9698019 (1), 15522937 (1) (see all 6)
    18-hydroxydeoxycorticosterone 76.7 4 11549669 (3)
    corticosterone 74.8 34 7852500 (2), 11275950 (2), 8077359 (1), 15947886 (1) (see all 22)
    fludrocortisone 72.5 1 15782303 (1)
    tetrahydro-11-deoxycortisol 71.8 1 15134824 (1)

    Search CenterWatch for drugs/clinical trials and news about CYP11B2 / C11B2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CYP11B2 gene: 
    NM_000498.3  

    Unigene Cluster for CYP11B2:

    Cytochrome P450, family 11, subfamily B, polypeptide 2
    Hs.632054  [show with all ESTs]
    Unigene Representative Sequence: NM_000498
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000323110(uc003yxk.1)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CYP11B2
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate CYP11B2
    SwitchGear 3'UTR luciferase reporter plasmidCYP11B2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CYP11B2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CYP11B2
    Clone
    Products:
         
    OriGene clones in human, mouse for CYP11B2 (see all 7)
    OriGene ORF clones in mouse, rat for CYP11B2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CYP11B2 (NM_000498)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CYP11B2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CYP11B2
    Sirion Biotech Customized lentivirus for stable overexpression of CYP11B2 
                         Customized lentivirus expression plasmids for stable overexpression of CYP11B2 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for CYP11B2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CYP11B2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CYP11B2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CYP11B2

    Additional mRNA sequence: X54741.1 

    1 DOTS entry:

    DT.95080617 

    10 AceView cDNA sequences:

    BV199117 X54741 BV183624 BV198798 BV198800 NM_000498 T28774 BV195495 
    AV710391 BF791620 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CYP11B2 expression in normal human tissues (normalized intensities)      CYP11B2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAAAGGAAT
    CYP11B2 Expression
    About this image


    CYP11B2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/24 selected tissues (see all 24) fully expand
     
     Uterus
             uterus, pre-menopause ; glandular cells   
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 3 entries
             rectum ; glandular cells   
     
     Adrenal Gland (Endocrine System)    fully expand to see all 2 entries
             adrenal gland ; glandular cells   
             Adrenal Cortex   
     
     Intestine (Gastrointestinal Tract)    fully expand to see all 2 entries
             small intestine ; glandular cells   

    See CYP11B2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CYP11B2

    SOURCE GeneReport for Unigene cluster: Hs.632054
        SABiosciences Expression via Pathway-Focused PCR Arrays including CYP11B2: 
              Drug Metabolism: Phase I Enzymes in human mouse rat
              Cellular Stress Responses in human mouse rat
              Drug Metabolism in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for CYP11B2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CYP11B2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CYP11B2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CYP11B2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYP11B2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for CYP11B2 gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cyp11b25
    Cyp11b11
    cytochrome P450, family 11, subfamily b, polypeptide 2 less5
    cytochrome P450, family 11, subfamily b, polypeptide 1 less1
    73.48(n)1
    64.93(a)1
      15 (34.29 cM)5
    1101151  NM_001033229.31  NP_001028401.21 
     748510105 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    51(a)
    1 → many
    AAWZ02036987(3866-16154)
    zebrafish
    (Danio rerio)
    Actinopterygii cyp11c11 cytochrome P450, family 11, subfamily C, polypeptide 1 less 55.67(n)
    45.29(a)
      791124  NM_001080204.1  NP_001073673.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Cyp12c13 cytochrome P450 31(a)
    (best of 2)
      75D6   --
    worm
    (Caenorhabditis elegans)
    Secernentea ccp-443 cytochrome p450 27(a)   II(5504020-5505870)   --


    ENSEMBL Gene Tree for CYP11B2 (if available)
    TreeFam Gene Tree for CYP11B2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CYP11B2 gene
    CYP11A12  CYP27A12  CYP11B12  CYP24A12  CYP27C12  CYP27B12  
    6 SIMAP similar genes for CYP11B2 using alignment to 3 protein entries:     C11B2_HUMAN (see all proteins):
    CYP11B1    CYP11A1    CYP27C1    CYP27B1    CYP24    CYP24A1

    CYP11B2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/470 SNPs in CYP11B2 are shown (see all 470)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0012684
    Corticosterone methyloxidase 2 deficiency (CMO-2 deficiency)4--see VAR_0012682 E D mis40--------
    VAR_0184724
    Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency)4--see VAR_0184722 L P mis40--------
    VAR_0012694
    Corticosterone methyloxidase 2 deficiency (CMO-2 deficiency)4--see VAR_0012692 V A mis40--------
    VAR_0184734
    Corticosterone methyloxidase 2 deficiency (CMO-2 deficiency)4--see VAR_0184732 T A mis40--------
    VAR_0184714
    Corticosterone methyloxidase 2 deficiency (CMO-2 deficiency)4--see VAR_0184712 T I mis40--------
    rs725546261,2
    Cpathogenic1144267999(-) TCCTCA/GCTTTC 2 T A mis10--------
    rs725546271,2
    Cpathogenic1144268545(-) GATGCC/TGCTGC 2 P L mis10--------
    rs617572941,2
    C,Fpathogenic1144268849(+) AGCTCA/GCCACT 2 A V mis15Minor allele frequency- G:0.06NS CSA NA EU 6074
    rs1219129771,2
    Cpathogenic1144270740(-) GGAAGG/TAGCAC 2 E * stg11Minor allele frequency- T:0.00NA 4516
    rs1048940721,2
    Cpathogenic1144271046(-) ATAGAA/CGGTGT 2 E D mis10--------

    HapMap Linkage Disequilibrium report for CYP11B2 (143991975 - 143999259 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for CYP11B2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2673440CNV Deletion23128226
    esv991235CNV Deletion20482838
    esv2737938CNV Deletion23290073
    nsv436586CNV Deletion17901297
    esv2661137CNV Deletion23128226
    nsv891648CNV Loss21882294
    nsv470246CNV Loss18288195


    Human Gene Mutation Database (HGMD): CYP11B2
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CYP11B2
    DNA2.0 Custom Variant and Variant Library Synthesis for CYP11B2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 124080   
    OMIM disorders: 610600  203400  
    UniProtKB/Swiss-Prot: C11B2_HUMAN, P19099
  • Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency) [MIM:203400]: Autosomal recessive disorder
    of aldosterone biosynthesis. There are two biochemically different forms of selective aldosterone deficiency be
    termed corticosterone methyloxidase (CMO) deficiency type 1 and type 2. In CMO-1 deficiency, aldosterone is
    undetectable in plasma, while its immediate precursor, 18-hydroxycorticosterone, is low or normal. Note=The
    disease is caused by mutations affecting the gene represented in this entry
  • Corticosterone methyloxidase 2 deficiency (CMO-2 deficiency) [MIM:610600]: Autosomal recessive disorder
    of aldosterone biosynthesis. In CMO-2 deficiency, aldosterone can be low or normal, but at the expense of
    increased secretion of 18-hydroxycorticosterone. Consequently, patients have a greatly increased ratio of
    18-hydroxycorticosterone to aldosterone and a low ratio of corticosterone to 18-hydroxycorticosterone in serum.
    Note=The disease is caused by mutations affecting the gene represented in this entry
  • Familial hyperaldosteronism 1 (FH1) [MIM:103900]: A disorder characterized by hypertension, variable
    hyperaldosteronism, and abnormal adrenal steroid production, including 18-oxocortisol and 18-hydroxycortisol.
    There is significant phenotypic heterogeneity, and some individuals never develop hypertension. Note=The disease
    is caused by mutations affecting the gene represented in this entry. The molecular defect causing
    hyperaldosteronism familial 1 is an anti-Lepore-type fusion of the CYP11B1 and CYP11B2 genes. The hybrid gene has
    the promoting part of CYP11B1, ACTH-sensitive, and the coding part of CYP11B2

  • 20/57 diseases for CYP11B2 (see all 57):    About MalaCards
    glucocorticoid-remediable aldosteronism    hypoaldosteronism    corticosterone methyloxidase type i deficiency    familial hyperreninemic hypoaldosteronism type 2
    hypoaldosteronism, congenital, due to cmo ii deficiency    hypoaldosteronism, congenital, due to cmo i deficiency    hyperaldosteronism    familial hyperaldosteronism
    aortic coarctation    corticosterone methyloxidase type ii deficiency    pulmonary edema    endocrine diseases
    11-beta-hydroxylase-deficient congenital adrenal hyperplasia    conn's syndrome    adrenocortical carcinoma    systolic heart failure
    liddle syndrome    adrenal adenoma    essential hypertension    hypertensive heart disease

    7 diseases from the University of Copenhagen DISEASES database for CYP11B2:
    Hyperaldosteronism     Conn's syndrome     Hypertension     Adenoma
    Hypokalemia     Adrenocortical carcinoma     Cushing's syndrome

    CYP11B2 for disorders           About GeneDecksing

    10/42 Novoseek inferred disease relationships for CYP11B2 gene (see all 42)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glucocorticoid-remediable aldosteronism 93.7 15 11600544 (2), 18505761 (1), 8954032 (1), 10843166 (1) (see all 10)
    cmo i deficiency 92.8 4 7852500 (1), 8439335 (1), 9177280 (1)
    hyperaldosteronism 90 21 10914997 (2), 15062555 (1), 18505761 (1), 9745430 (1) (see all 16)
    hypoaldosteronism 88.5 21 11701710 (3), 11422109 (2), 16733366 (2), 7852500 (1) (see all 10)
    aldosteronism primary 88 25 2256920 (2), 20339375 (2), 12608705 (2), 11422106 (2) (see all 16)
    essential hypertension 78.3 42 15505931 (3), 12444540 (2), 12817181 (2), 16126185 (2) (see all 28)
    low renin hypertension 73.5 2 11587161 (1), 8784078 (1)
    adrenal hyperplasia congenital 71.1 5 11443188 (1), 11549691 (1), 15134805 (1), 9300202 (1)
    adrenal hyperplasia 67.4 3 7758082 (1), 11443188 (1), 15248825 (1)
    myocardial fibrosis 65.1 12 11914098 (2), 16220979 (2), 16246562 (1), 16570918 (1) (see all 5)

    Genetic Association Database (GAD): CYP11B2
    Human Genome Epidemiology (HuGE) Navigator: CYP11B2 (189 documents)

    Export disorders for CYP11B2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CYP11B2 gene, integrated from 9 sources (see all 519):
    (articles sorted by number of sources associating them with CYP11B2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Haplotypes of aldosterone synthase (CYP11B2) gene in the general population of Japan: the Ohasama study. (PubMed id 11728005)1, 4, 9 Matsubara M....Imai Y. (2001)
    2. Mutation analysis of CYP11B1 and CYP11B2 in patients with increased 18-hydroxycortisol production. (PubMed id 15062555)1, 4, 9 Nicod J....Ferrari P. (2004)
    3. Congenitally defective aldosterone biosynthesis in humans: inactivation of the P-450(C18) gene (CYP11B2) due to nucleotide deletion in CMO I deficient patients. (PubMed id 8439335)1, 2, 9 Mitsuuchi Y.... Shizuta Y. (1993)
    4. [Impact of gene-environment interaction between the C (-344) T polymorphism of CYP11B2 and drinking index on the risk of hypertensio n under multifactor dimensionality reduction model in Chinese Mongolian populat ion] (PubMed id 20193236)1, 4, 9 Pan X.Q....Tong W.J. (2009)
    5. Multiple Polymorphisms in the renin- angiotensin-aldosterone system (ACE, CYP11B2, AGTR1) and their contribution to hypertension in African Americans and Latinos in the multiethnic cohort. (PubMed id 15545843)1, 4, 9 Henderson S.O....Mack W. (2004)
    6. CYP11B2 polymorphisms and home blood pressure in a population-based cohort in Japanese: the Ohasama study. (PubMed id 15055249)1, 4, 9 Matsubara M....Imai Y. (2004)
    7. The -344T>C promoter variant of the gene for aldosterone synthase (CYP11B2) is not associated with cardiovascular risk in a prospective study of UK healthy men. (PubMed id 15135254)1, 4, 9 Payne J.R....Montgomery H.E. (2004)
    8. [Associations of the genetic polymorphisms in CYP11B2 gene with nonfamilial structural atrial fibrillation] (PubMed id 20193392)1, 4, 9 Cao F.F....Jin L. (2009)
    9. Effect of variation in CYP11B1 and CYP11B2 on corticosteroid phenotype and hypothalamic-pituitary-adrenal axis activity in hypertensive and normotensive subjects. (PubMed id 17980006)1, 4, 9 Freel E.M....Connell J.M. (2008)
    10. Association of the C-344T polymorphism of CYP11B2 gene with essential hypertension in Hani and Yi minorities of China. (PubMed id 16126185)1, 4, 9 Tang W....Xiao C. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1585 HGNC: 2592 AceView: CYP11B2 Ensembl:ENSG00000179142 euGenes: HUgn1585
    ECgene: CYP11B2 Kegg: 1585 H-InvDB: CYP11B2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CYP11B2 Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/CYP11B2
    Wikipedia http://en.wikipedia.org/wiki/CYP11B2

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CYP11B2 gene:
    Search GeneIP for patents involving CYP11B2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for CYP11B2  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for CYP11B2  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for CYP11B2  
     OriGene qSTAR qPCR primer pairs in human, mouse for CYP11B2   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for CYP11B2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CYP11B2   OriGene Custom Protein Services for CYP11B2  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CYP11B2
     QIAGEN SeqTarget long-range PCR primers for resequencing CYP11B2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CYP11B2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CYP11B2
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CYP11B2
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CYP11B2
     GenScript Custom Purified and Recombinant Proteins Services for CYP11B2 GenScript cDNA clones with any tag delivered in your preferred vector for CYP11B2
     GenScript Custom Assay Services for CYP11B2 GenScript Custom Superior Antibodies Services for CYP11B2
     GenScript Custom overexpressing Cell Line Services for CYP11B2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in CYP11B2 promoter
     Search Chromatin IP Primers for CYP11B2
     RT2 qPCR Primer Assay in human, mouse, rat CYP11B2
     GNC Network for CYP11B2
     SABiosciences PCR Arrays including human, mouse, rat CYP11B2
     Search Tocris compounds for CYP11B2 (C11B2)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     CYP11B2 antibodies
     CYP11B2 lysates
     Antibodies for CYP11B2
     See all of Abcam's Antibodies, Kits and Proteins for CYP11B2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.
     Search LifeMap BioReagents cell lines for CYP11B2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYP11B2
     SwitchGear 3'UTR luciferase reporter plasmids for CYP11B2
     SwitchGear Promoter luciferase reporter plasmids for CYP11B2
     Search ThermoFisher Antibodies for CYP11B2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CYP11B2
     inGenious Targeting Laboratory - Custom generated mouse model solutions for CYP11B2
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CYP11B2
    Customized:
     lentivirus for stable overexpression of CYP11B2
     lentivirus expression plasmids for stable overexpression of CYP11B2
     adenovirus for overexpression of CYP11B2
     LSBio Antibodies in human, mouse, rat for CYP11B2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CYP11B2 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4