Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



CYP11B1 Gene

protein-coding   GIFtS: 64
GCID: GC08M143950

Cytochrome P450, Family 11, Subfamily B, Polypeptide 1

(Previous names: cytochrome P450, subfamily XIB (steroid 11-beta-hydroxylase),...)
(Previous symbol: CYP11B)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Cytochrome P450, Family 11, Subfamily B, Polypeptide 11 2     EC 1.14.15.43 8
CYP11B1 2     FHI2 5
Cytochrome P450, Subfamily XIB (Steroid 11-Beta-Hydroxylase), Polypeptide
11 2
     P450C112 5
Steroid 11-Beta-Monooxygenase1 2     CPN12
Cytochrome P-450c112 3     Cytochrome P450 11B1, Mitochondrial2
Cytochrome P450C112 3     Cytochrome P450 XIB12
Steroid 11-Beta-Hydroxylase2 3     S11BH3
CYPXIB12 3     EC 1.14.158

External Ids:    HGNC: 25911   Entrez Gene: 15842   Ensembl: ENSG000001608827   OMIM: 6106135   UniProtKB: P155383   

Export aliases for CYP11B1 gene to outside databases

Previous GC identifers: GC08M142258 GC08M144187 GC08M143758 GC08M144016 GC08M139206


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for CYP11B1 Gene:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are
monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids
and other lipids. This protein localizes to the mitochondrial inner membrane and is involved in the conversion of
progesterone to cortisol in the adrenal cortex. Mutations in this gene cause congenital adrenal hyperplasia due
to 11-beta-hydroxylase deficiency. Transcript variants encoding different isoforms have been noted for this gene.
(provided by RefSeq, Jul 2008)

GeneCards Summary for CYP11B1 Gene:
CYP11B1 (cytochrome P450, family 11, subfamily B, polypeptide 1) is a protein-coding gene. Diseases associated with CYP11B1 include glucocorticoid-remediable aldosteronism, and 11-beta-hydroxylase-deficient congenital adrenal hyperplasia. GO annotations related to this gene include electron carrier activity and heme binding. An important paralog of this gene is CYP19A1.

UniProtKB/Swiss-Prot: C11B1_HUMAN, P15538
Function: Has steroid 11-beta-hydroxylase activity. In addition to this activity, the 18 or 19-hydroxylation of
steroids and the aromatization of androstendione to estrone have also been ascribed to cytochrome P450 XIB

summary for CYP11B1 Gene:
Cytochrome P450 (CYP450) enzymes are a diverse group of catalysts that contains 57 members in humans. CYPs
are usually membrane-bound and are localized to the inner mitochondrial or endoplasmic reticular membrane.
CYPs have oxygenase activity and commonly catalyze redox reactions, involving the oxidation of the substrate
and reduction of water. This group of enzymes contain a heme ion within the active site, which is essential
for catalytic activity. CYPs have been found in all organisms tested and are ubiquitously expressed. They
are found at high levels in the liver, where they have an important role in metabolism of drugs and
endogenous toxic compounds (for example bilirubin). Most CYPs can metabolize numerous substrates and this
accounts for their major role in drug interactions. CYPs also have functions in steroid hormone synthesis,
cholesterol synthesis and vitamin D metabolism.

Gene Wiki entry for CYP11B1 (Steroid 11-beta-hydroxylase) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000008.11  NT_008046.17  NC_018919.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CYP11B1 gene promoter:
         Bach1   NF-1/L   NF-1   GCNF   Lmo2   YY1   HEN1   GCNF-1   GCNF-2   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCYP11B1 promoter sequence
   Search Chromatin IP Primers for CYP11B1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CYP11B1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q21   Ensembl cytogenetic band:  8q24.3   HGNC cytogenetic band: 8q21-q22

CYP11B1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CYP11B1 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M143950:  view genomic region     (about GC identifiers)

Start:
143,953,772 bp from pter      End:
143,961,262 bp from pter
Size:
7,491 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: C11B1_HUMAN, P15538 (See protein sequence)
Recommended Name: Cytochrome P450 11B1, mitochondrial precursor  
Size: 503 amino acids; 57573 Da
Cofactor: Heme group (By similarity)
Secondary accessions: Q14095 Q4VAQ8 Q4VAQ9 Q9UML2
Alternative splicing: 2 isoforms:  P15538-1   P15538-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CYP11B1: NX_P15538

Explore proteomics data for CYP11B1 at MOPED

Selected DME Specific Peptides for CYP11B1 (P15538) (see all 8)
 RQCLGRR  IPAGTLV  AGSVDTT  VQQALRQES 


See CYP11B1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (2 alternative transcripts): 
NP_000488.3  NP_001021384.1  

ENSEMBL proteins: 
 ENSP00000430144   ENSP00000292427   ENSP00000428043   ENSP00000366903  
Reactome Protein details: P15538

CYP11B1 Human Recombinant Protein Products:

Browse Purified and Recombinant Proteins at EMD Millipore
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
OriGene Purified Protein for CYP11B1
OriGene Protein Over-expression Lysate for CYP11B1
OriGene MassSpec for CYP11B1
OriGene Custom Protein Services for CYP11B1
GenScript Custom Purified and Recombinant Proteins Services for CYP11B1
Novus Biologicals CYP11B1 Protein
Novus Biologicals CYP11B1 Lysates
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates
Browse ProSpec Recombinant Proteins
Cloud-Clone Corp. Proteins for CYP11B1

CYP11B1 Antibody Products:

Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse R&D Systems for Antibodies
OriGene Antibodies for CYP11B1
OriGene Custom Antibody Services for CYP11B1
Novus Biologicals CYP11B1 Antibodies
Search for Antibodies for CYP11B1 at Abcam
Cloud-Clone Corp. Antibodies for CYP11B1
ThermoFisher Antibody for CYP11B1
LSBio Antibodies in human, mouse, rat for CYP11B1

CYP11B1 Assay Products:

Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for CYP11B1
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for CYP11B1
Browse Enzo Life Sciences for kits & assays
Cloud-Clone Corp. ELISAs for CYP11B1
Cloud-Clone Corp. CLIAs for CYP11B1


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TryGeneCards Plus
HGNC Gene Families:
CYP: Cytochrome P450s

IUPHAR Guide to PHARMACOLOGY protein family classification: CYP11B1
CYP11, CYP17, CYP19, CYP20 and CYP21 families

3 InterPro protein domains:
 IPR001128 Cyt_P450
 IPR017972 Cyt_P450_CS
 IPR002399 Cyt_P450_mitochondrial

Graphical View of Domain Structure for InterPro Entry P15538

ProtoNet protein and cluster: P15538

1 Blocks protein domain: IPB002399 Mitochondrial P450 clan signature

UniProtKB/Swiss-Prot: C11B1_HUMAN, P15538
Similarity: Belongs to the cytochrome P450 family


CYP11B1 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Molecular Function:

     UniProtKB/Swiss-Prot Summary: C11B1_HUMAN, P15538
Function: Has steroid 11-beta-hydroxylase activity. In addition to this activity, the 18 or 19-hydroxylation of
steroids and the aromatization of androstendione to estrone have also been ascribed to cytochrome P450 XIB
Catalytic activity: A steroid + reduced adrenodoxin + O(2) = an 11-beta-hydroxysteroid + oxidized adrenodoxin +
H(2)O

     Genatlas biochemistry entry for CYP11B1:
cytochrome p450,subfamily XIB,polypeptide 1,steroid 11 beta-hydroxylase,mitochondrial,involved in glucocorticoid
biosynthesis,stimulated by corticotropin,expressed in zona fasciculata of the adrenal cortex

     Enzyme Numbers (IUBMB): EC 1.14.15.41 2 EC 1.14.152

     Gene Ontology (GO): 5 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004497monooxygenase activity ----
GO:0004507steroid 11-beta-monooxygenase activity IMP2022736
GO:0005506iron ion binding IEA--
GO:0016705oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen ----
GO:0020037heme binding IC2256920
     
CYP11B1 for ontologies           About GeneDecksing


Phenotypes:
     1 GenomeRNAi human phenotype for CYP11B1:
 Synthetic lethal with Ras 

     11 MGI mutant phenotypes (inferred from 1 allele(MGI details for Cyp11b1):
 adipose tissue  cardiovascular system  endocrine/exocrine gland  growth/size/body  hematopoietic system 
 homeostasis/metabolism  immune system  liver/biliary system  nervous system  renal/urinary system 
 reproductive system 

CYP11B1 for phenotypes           About GeneDecksing

Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CYP11B1
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CYP11B1

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CYP11B1
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CYP11B1

miRNA
Products:
    
Block miRNA regulation of human, mouse, rat CYP11B1 using miScript Target Protectors
Search for qRT-PCR Assays for microRNAs that regulate CYP11B1
SwitchGear 3'UTR luciferase reporter plasmidCYP11B1 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for CYP11B1
Predesigned siRNA for gene silencing in human, mouse, rat CYP11B1

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for CYP11B1

Clone
Products:
     
OriGene clones in human, mouse for CYP11B1 (see all 11)
OriGene ORF clones in mouse, rat for CYP11B1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 2): CYP11B1 (NM_001026213)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for CYP11B1
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CYP11B1

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for CYP11B1
Browse ESI BIO Cell Lines and PureStem Progenitors for CYP11B1 
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYP11B1


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Subcellular locations from UniProtKB/Swiss-Prot
C11B1_HUMAN, P15538: Mitochondrion membrane
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
mitochondrion5
cytosol2
nucleus2
peroxisome2

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005739mitochondrion IDA2256920
GO:0005743mitochondrial inner membrane TAS15026188

CYP11B1 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
About This Section

TryGeneCards Plus

SuperPaths for CYP11B1 About   (see all 8)                                                                                              See pathways by source

SuperPathContained pathways About
1Metabolism of steroid hormones and vitamin D
Mineralocorticoid biosynthesis0.00
glucocorticoid biosynthesis0.00
Metabolism of steroid hormones and vitamin D
Glucocorticoid biosynthesis0.00
mineralocorticoid biosynthesis0.00
2Cytochrome P450 - arranged by substrate type
Cytochrome P450 - arranged by substrate type0.75
cytochrome P4500.74
Phase 1 - Functionalization of compounds0.75
Endogenous sterols0.00
3Metabolism
Metabolism0.38
Metabolism of lipids and lipoproteins0.37
Metabolic pathways0.38
4Biological oxidations
Biological oxidations0.56
metapathway biotransformation0.42
5Estrone metabolism
Estrogen biosynthesis0.47

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


1 GeneGo (Thomson Reuters) Pathway for CYP11B1
    Estrogen biosynthesis

Selected BioSystems Pathways for CYP11B1 (see all 6)
    cytochrome P450
glucocorticoid biosynthesis
mineralocorticoid biosynthesis
superpathway of steroid hormone biosynthesis
Corticotropin-releasing hormone

3 Reactome Pathways for CYP11B1
    Endogenous sterols
Mineralocorticoid biosynthesis
Glucocorticoid biosynthesis


2 Kegg Pathways  (Kegg details for CYP11B1):
    Steroid hormone biosynthesis
Metabolic pathways


CYP11B1 for pathways           About GeneDecksing

    Pathway & Disease-focused RT2 Profiler PCR Array including CYP11B1: 
          Drug Metabolism: Phase I Enzymes in human mouse rat

Interactions:

    GeneGlobe Interaction Network for CYP11B1

STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

Selected Interacting proteins for CYP11B1 (P155383 ENSP000002924274) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
InteractantInteraction Details
GeneCardExternal ID(s)
CYP11B2P190993, ENSP000003258224I2D: score=1 STRING: ENSP00000325822
CYP17A1ENSP000003589034STRING: ENSP00000358903
CYP19A1ENSP000002604334STRING: ENSP00000260433
ENSG00000232414ENSP000004165984STRING: ENSP00000416598
HSD11B1ENSP000002614654STRING: ENSP00000261465
About this table

Gene Ontology (GO): Selected biological process terms (see all 15):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006700C21-steroid hormone biosynthetic process IDA2256920
GO:0006704glucocorticoid biosynthetic process TAS--
GO:0006705mineralocorticoid biosynthetic process TAS--
GO:0006805xenobiotic metabolic process TAS--
GO:0006955immune response TAS12452430

CYP11B1 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
About This Section

TryGeneCards Plus
Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Compounds for CYP11B1 available from Tocris Bioscience    About this table
CompoundAction CAS #
Metyrapone11-beta hydroxylase inhibitor[54-36-4]
DMOGProlylhydroxylase inhibitor[89464-63-1]
Ro 61-8048Potent kynurenine 3-hydroxylase inhibitor[199666-03-0]

Selected HMDB Compounds for CYP11B1 (see all 21)    About this table
CompoundSynonyms CAS #PubMed Ids
Cortexolone11-Deoxy-17-hydroxycorticosterone (see all 21)152-58-91775135
Deoxycorticosterone11-Dehydroxycorticosterone (see all 21)64-85-71775135
11b,17a,21-Trihydroxypreg-nenolone11beta,17alpha,21-Trihydroxypregnenolone (see all 2)----
11b-Hydroxyandrost-4-ene-3,17-dioneAndrost-4-ene-3,17-dione-11beta-ol (see all 3)382-44-5--
11b-Hydroxyprogesterone11b-Hydroxyprogesterone (see all 7)600-57-7--
11beta-Hydroxyprogesterone ----
17-Hydroxyprogesterone17-OHP (see all 15)68-96-2--
17a,21-Dihydroxypreg-nenolone17alpha,21-Dihydroxypregnenolone (see all 2)1167-48-2--
18-Hydroxycorticosterone11b,18,21-trihydroxy-pregn-4-ene-3,20-dione (see all 2)561-65-9--
19-Hydroxydeoxycorticosterone11-deoxy-19-hydroxycorticosterone;11-desoxy-19-hydroxycorticosterone;19,21-dihydroxy-4-pregnene-3,20-dione;19,21-dihydroxypregn-4-ene-3,20-dione;19-Hydroxy-11-deoxycorticosterone;19-Hydroxy-11-desoxycorticosterone 2394-23-2--

Selected DrugBank Compounds for CYP11B1 (see all 14)    About this table
CompoundSynonyms CAS #TypeActionsPubMed Ids
MetyraponeMepyrapone (see all 9)54-36-4targetinhibitor17487473 11869873 17462829 11752352
enzymeinhibitor17487473 11869873 17462829 11752352 19934256
Aldosterone(+)-aldosterone (see all 18)52-39-1enzymesubstrate19934256
Cimetidine-- 51481-61-9enzymeinhibitor19934256
ClotrimazoleChlotrimazole (see all 2)23593-75-1enzymeinhibitor19934256
Etomidate-- 33125-97-2enzymeinhibitor19934256
Fluconazole-- 86386-73-4enzymeinhibitor19934256
Hydrocortisone11beta-Hydroxycortisone (see all 16)50-23-7enzymesubstrate19934256
Ketoconazole2% (see all 6)65277-42-1enzymeinhibitor19934256
MetoclopramideMetaclopramide (see all 9)364-62-5enzymeinhibitor19934256
Mibefradil-- 116644-53-2enzymeinhibitor19934256

Selected Novoseek inferred chemical compound relationships for CYP11B1 gene (see all 38)    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
11 deoxycortisol 91.5 14 8530633 (1), 1775135 (1), 10559665 (1), 15755848 (1) (see all 12)
18-oxocortisol 91.5 5 8800594 (2), 1741400 (2), 10994747 (1)
18-hydroxycorticosterone 89.1 4 2298865 (1), 10411633 (1), 8123004 (1)
18-hydroxycortisol 88 3 15062555 (2), 10994747 (1)
doca 86.2 8 7673111 (1), 16105656 (1), 2298865 (1), 1775135 (1) (see all 8)
18-hydroxydeoxycorticosterone 77.4 1 11549669 (1)
acth 76.6 32 11903322 (2), 11595502 (2), 10994747 (2), 1310416 (1) (see all 24)
steroid 73.8 51 16024935 (2), 15807871 (2), 11443188 (2), 8088295 (2) (see all 40)
pcb 126 71.9 17 16396990 (5), 17350062 (4), 15703266 (2)
3beta-hydroxysteroid 66.8 8 11701663 (1), 9880115 (1), 16981135 (1), 16973756 (1) (see all 8)



CYP11B1 for compounds           About GeneDecksing



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
About This Section

TryGeneCards Plus

REFSEQ mRNAs for CYP11B1 gene (2 alternative transcripts): 
NM_000497.3  NM_001026213.1  

Unigene Cluster for CYP11B1:

Cytochrome P450, family 11, subfamily B, polypeptide 1
Hs.184927  [show with all ESTs]
Unigene Representative Sequence: NM_000497
5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000314111(uc003yxh.3 uc003yxi.3 uc003yxj.3 uc010mey.3)
ENST00000519285(uc010mex.3) ENST00000292427 ENST00000517471 ENST00000377675

miRNA
Products:
     
Block miRNA regulation of human, mouse, rat CYP11B1 using miScript Target Protectors
Search for qRT-PCR Assays for microRNAs that regulate CYP11B1
SwitchGear 3'UTR luciferase reporter plasmidCYP11B1 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for CYP11B1
Predesigned siRNA for gene silencing in human, mouse, rat CYP11B1
Clone
Products:
     
OriGene clones in human, mouse for CYP11B1 (see all 11)
OriGene ORF clones in mouse, rat for CYP11B1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 2): CYP11B1 (NM_001026213)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for CYP11B1
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CYP11B1
Primer
Products:
    
OriGene qPCR primer pairs and template standards for CYP11B1
OriGene qSTAR qPCR primer pairs in human, mouse for CYP11B1
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CYP11B1
  QuantiTect SYBR Green Assays in human, mouse, rat CYP11B1
  QuantiFast Probe-based Assays in human, mouse, rat CYP11B1

Additional mRNA sequence: 

AF478474.1 BC096285.3 BC096286.3 BC096287.3 BX647738.1 M24667.1 X55764.1 

13 DOTS entries:

DT.92430889  DT.102825805  DT.99996152  DT.40286765  DT.92430900  DT.101957314  DT.95070826  DT.121479667 
DT.121479688  DT.92430899  DT.95141897  DT.121479682  DT.92430898 

Selected AceView cDNA sequences (see all 89):

AV707112 AA605202 BX642335 AA564584 AF478474 AV709131 AV709464 AI791941 
CB986007 NM_000497 AV709422 AV708822 AV705864 X55764 BX509275 AV703325 
AV708701 AV702884 AV704246 AV702075 BX642334 AV711336 CD608634 AV710319 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TryGeneCards Plus

CYP11B1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
CYP11B1 Expression
About this image

CYP11B1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

CYP11B1 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.184927
    Pathway & Disease-focused RT2 Profiler PCR Array including CYP11B1: 
          Drug Metabolism: Phase I Enzymes in human mouse rat

Primer
Products:
OriGene qPCR primer pairs and template standards for CYP11B1
OriGene qSTAR qPCR primer pairs in human, mouse for CYP11B1
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CYP11B1
QuantiTect SYBR Green Assays in human, mouse, rat CYP11B1
QuantiFast Probe-based Assays in human, mouse, rat CYP11B1
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYP11B1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

TryGeneCards Plus

This gene was present in the common ancestor of animals.

Orthologs for CYP11B1 gene from Selected species (see all 13)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Cyp11b15
Cyp11b21
cytochrome P450, family 11, subfamily b, polypeptide more1, 5 74.87(n)1
68.2(a)1
  15 (34.29 cM)5
130721  NM_009991.31  NP_034121.31 
 748348925 
lizard
(Anolis carolinensis)
Reptilia --
Uncharacterized protein
50(a)
1 → many
AAWZ02036987(3866-16154)
tropical clawed frog
(Xenopus tropicalis)
Amphibia LOC1017310701 cytochrome P450 11B, mitochondrial-like 57.52(n)
51.36(a)
  101731070  XM_004920024.1  XP_004920081.1 
zebrafish
(Danio rerio)
Actinopterygii cyp11c11 cytochrome P450, family 11, subfamily C, polypeptide more 55.27(n)
43.87(a)
  791124  NM_001080204.1  NP_001073673.1 
fruit fly
(Drosophila melanogaster)
Insecta Cyp12c13 cytochrome P450 29(a)   75D6   --
worm
(Caenorhabditis elegans)
Secernentea ccp-443 cytochrome p450 26(a)   II(5504020-5505870)   --


ENSEMBL Gene Tree for CYP11B1 (if available)
TreeFam Gene Tree for CYP11B1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section

TryGeneCards Plus
Paralogs for CYP11B1 gene
CYP19A12  CYP24A12  CYP46A12  CYP11B22  CYP27B12  CYP11A12  CYP27A12  CYP27C12  
7 SIMAP similar genes for CYP11B1 using alignment to 9 protein entries:     C11B1_HUMAN (see all proteins):
CYP11B2    CYP11A1    CYP3A5    CYP24A1    CYP27B1    CYP27C1
CYP2E1

CYP11B1 for paralogs           About GeneDecksing


1 Pseudogenes.org Pseudogene for CYP11B1
PGOHUM00000249518


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

TryGeneCards Plus

Selected SNPs for CYP11B1 (see all 535)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 8 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs289345861,2,,4
CAdrenal hyperplasia 4 (AH4)4 pathogenic1144231010(-) CATGCA/GCCAGT 3 H R mis1 int1 ese30--------
VAR_0656664
Adrenal hyperplasia 4 (AH4)4--see VAR_0656662 P L mis40--------
VAR_0012604
Adrenal hyperplasia 4 (AH4)4--see VAR_0012602 P S mis40--------
VAR_0012624
Adrenal hyperplasia 4 (AH4)4--see VAR_0012622 T M mis40--------
VAR_0012614
Adrenal hyperplasia 4 (AH4)4--see VAR_0012612 N H mis40--------
VAR_0651964
Adrenal hyperplasia 4 (AH4)4--see VAR_0651962 G V mis40--------
VAR_0012634
Adrenal hyperplasia 4 (AH4)4--see VAR_0012632 T M mis40--------
VAR_0012644
Adrenal hyperplasia 4 (AH4)4--see VAR_0012642 R Q mis40--------
VAR_0656674
Adrenal hyperplasia 4 (AH4)4--see VAR_0656672 T R mis40--------
VAR_0651974
Adrenal hyperplasia 4 (AH4)4--see VAR_0651972 R C mis40--------

HapMap Linkage Disequilibrium report for CYP11B1 (143953772 - 143961262 bp)

Structural Variations
     Database of Genomic Variants (DGV) 10 variations for CYP11B1:    About this table    
Variant IDTypeSubtypePubMed ID
esv2673440CNV Deletion23128226
esv991235CNV Deletion20482838
esv2737938CNV Deletion23290073
nsv436586CNV Deletion17901297
esv2661137CNV Deletion23128226
nsv891647CNV Loss21882294
nsv470246CNV Loss18288195
nsv891648CNV Loss21882294
nsv520940CNV Gain19592680
nsv482123CNV Gain20164927

Human Gene Mutation Database (HGMD): CYP11B1
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing CYP11B1
DNA2.0 Custom Variant and Variant Library Synthesis for CYP11B1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TryGeneCards Plus
OMIM gene information: 610613   
OMIM disorders: 202010  103900  
UniProtKB/Swiss-Prot: C11B1_HUMAN, P15538
  • Adrenal hyperplasia 4 (AH4) [MIM:202010]: A form of congenital adrenal hyperplasia, a common recessive
    disease due to defective synthesis of cortisol. Congenital adrenal hyperplasia is characterized by androgen
    excess leading to ambiguous genitalia in affected females, rapid somatic growth during childhood in both sexes
    with premature closure of the epiphyses and short adult stature. Four clinical types: 'salt wasting' (SW, the
    most severe type), 'simple virilizing' (SV, less severely affected patients), with normal aldosterone
    biosynthesis, 'non-classic form' or late-onset (NC or LOAH)and 'cryptic' (asymptomatic). Note=The disease is
    caused by mutations affecting the gene represented in this entry
  • Familial hyperaldosteronism 1 (FH1) [MIM:103900]: A disorder characterized by hypertension, variable
    hyperaldosteronism, and abnormal adrenal steroid production, including 18-oxocortisol and 18-hydroxycortisol.
    There is significant phenotypic heterogeneity, and some individuals never develop hypertension. Note=The disease
    is caused by mutations affecting the gene represented in this entry. The molecular defect causing
    hyperaldosteronism familial 1 is an anti-Lepore-type fusion of the CYP11B1 and CYP11B2 genes. The hybrid gene has
    the promoting part of CYP11B1, ACTH-sensitive, and the coding part of CYP11B2

  • Selected diseases for CYP11B1 (see all 34):    About MalaCards
    glucocorticoid-remediable aldosteronism    11-beta-hydroxylase-deficient congenital adrenal hyperplasia    iridocyclitis    11-beta-hydroxylase deficiency
    congenital adrenal hyperplasia    hyperaldosteronism    familial hyperaldosteronism    adrenal adenoma
    low renin hypertension    pelvic inflammatory disease    conn's syndrome    21-hydroxylase deficiency
    cushing's syndrome    adrenocortical carcinoma    patent ductus arteriosus    congestive heart failure
    asperger syndrome    hyperandrogenism    essential hypertension    was-related disorders

    6 diseases from the University of Copenhagen DISEASES database for CYP11B1:
    Hyperaldosteronism     Conn's syndrome     Iridocyclitis     Hypertension
    Cushing's syndrome     Adrenocortical carcinoma

    CYP11B1 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for CYP11B1 gene (see all 20)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glucocorticoid-remediable aldosteronism 95.5 25 11600544 (2), 11903322 (1), 10843166 (1), 15941863 (1) (see all 19)
    adrenal hyperplasia congenital 90.4 44 15755848 (2), 11443188 (2), 8506298 (2), 8088295 (2) (see all 34)
    hyperaldosteronism 89.1 21 9745430 (2), 10994747 (2), 15062555 (1), 11128865 (1) (see all 16)
    aldosteronism primary 85.5 9 1820978 (2), 20339375 (2), 10566677 (1), 7882585 (1) (see all 7)
    adrenal hyperplasia 78.3 3 9302260 (1), 7758082 (1), 11443188 (1)
    adenoma adrenocortical 76.1 3 1820978 (2), 1535042 (1)
    virilization 70.7 3 1879383 (1), 11964027 (1), 18663314 (1)
    adrenal tumor 69.3 3 1775135 (1), 19564722 (1), 2401360 (1)
    cushing syndrome 62 5 19564722 (2), 12608705 (1), 20200334 (1)
    adenoma 59.7 18 1535042 (2), 12457455 (2), 19915020 (2), 7588406 (1) (see all 13)

    Genetic Association Database (GAD): CYP11B1
    Human Genome Epidemiology (HuGE) Navigator: CYP11B1 (34 documents)

    Export disorders for CYP11B1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for CYP11B1 gene, integrated from 10 sources (see all 278):
    (articles sorted by number of sources associating them with CYP11B1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A nonsense mutation (TGG [Trp116]-->TAG [Stop]) in CYP11B1 causes steroid 11 beta-hydroxylase deficiency. (PubMed id 7903314)1, 2, 9 Naiki Y.... Shizuta Y. (J. Clin. Endocrinol. Metab. 1993)
    2. A mutation in CYP11B1 (Arg-448-->His) associated with steroid 11 beta-hydroxylase deficiency in Jews of Moroccan origin. (PubMed id 2022736)1, 2, 9 White P.C....Roesler A. (J. Clin. Invest. 1991)
    3. Mutation analysis of CYP11B1 and CYP11B2 in patients with increased 18-hydroxycortisol production. (PubMed id 15062555)1, 4, 9 Nicod J....Ferrari P. (Mol. Cell. Endocrinol. 2004)
    4. Association between aldosterone production and variation in the 11beta-hydroxylase (CYP11B1) gene. (PubMed id 16984984)1, 4, 9 Imrie H....Connell J.M. (J. Clin. Endocrinol. Metab. 2006)
    5. Functional effects of genetic variants in the 11beta-hydroxylase (CYP11B1) gene. (PubMed id 17121536)1, 4, 9 Barr M....Davies E. (Clin. Endocrinol. (Oxf) 2006)
    6. CYP11B1 mutations causing non-classic adrenal hyperplasia due to 11 beta-hydroxylase deficiency. (PubMed id 9302260)1, 2, 9 Joehrer K.... White P.C. (Hum. Mol. Genet. 1997)
    7. Effect of variation in CYP11B1 and CYP11B2 on corticosteroid phenotype and hypothalamic-pituitary-adrenal axis activity in hypertensive and normotensive subjects. (PubMed id 17980006)1, 4, 9 Freel E.M....Connell J.M. (Clin. Endocrinol. (Oxf) 2008)
    8. Polymorphisms in CYP11B2 and CYP11B1 genes associated with primary hyperaldosteronism. (PubMed id 20339375)1, 4, 9 Zhang G.X....Zhang X. (Hypertens. Res. 2010)
    9. Role of steroid 11 beta-hydroxylase and steroid 18-hydroxylase in the biosynthesis of glucocorticoids and mineralocorticoids in humans. (PubMed id 1741400)1, 2, 9 Kawamoto T....Shuzuta Y. (Proc. Natl. Acad. Sci. U.S.A. 1992)
    10. CYP11B2-CYP11B1 haplotypes associated with decreased 11 beta-hydroxylase activity. (PubMed id 15507509)1, 4, 9 Ganapathipillai S....Ferrari P. (J. Clin. Endocrinol. Metab. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 1584 HGNC: 2591 AceView: CYP11B1 Ensembl:ENSG00000160882 euGenes: HUgn1584
    ECgene: CYP11B1 Kegg: 1584 H-InvDB: CYP11B1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for CYP11B1 Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=CYP11B1[genesymbol]

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for CYP11B1 gene:
    Search GeneIP for patents involving CYP11B1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for CYP11B1   OriGene RNAi products in human, mouse, rat for CYP11B1  
     OriGene qPCR primer pairs and template standards for CYP11B1   OriGene Protein Over-expression Lysate for CYP11B1  
     OriGene MassSpec something-or-other for CYP11B1   OriGene clones in human, mouse for CYP11B1  
     OriGene qSTAR qPCR primer pairs in human, mouse for CYP11B1   OriGene Purified Protein for CYP11B1  
     OriGene ORF clones in mouse, rat for CYP11B1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CYP11B1   OriGene Custom Protein Services for CYP11B1  

     
     
     Block miRNA regulation of human, mouse, rat CYP11B1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing CYP11B1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CYP11B1 Predesigned siRNA for gene silencing in human, mouse, rat CYP11B1
     QuantiFast Probe-based Assays in human, mouse, rat CYP11B1 QuantiTect SYBR Green Assays in human, mouse, rat CYP11B1
     PCR Arrays including human, mouse, rat CYP11B1 Search Chromatin IP Primers for CYP11B1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CYP11B1  GeneGlobe Interaction Network for CYP11B1
     Regulatory tfbs in CYP11B1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for CYP11B1 GenScript cDNA clones with any tag delivered in your preferred vector for CYP11B1
     GenScript Custom Assay Services for CYP11B1 GenScript Custom overexpressing Cell Line Services for CYP11B1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Tocris compounds for CYP11B1
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     CYP11B1 antibodies
     CYP11B1 proteins
     CYP11B1 lysates
     Search for Antibodies for CYP11B1 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for CYP11B1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for CYP11B1
     Antibodies for CYP11B1
     ELISAs for CYP11B1
     CLIAs for CYP11B1



     Browse ESI BIO Cell Lines and PureStem Progenitors for CYP11B1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYP11B1
     SwitchGear 3'UTR luciferase reporter plasmids for CYP11B1
     SwitchGear Promoter luciferase reporter plasmids for CYP11B1
     ThermoFisher Antibody for CYP11B1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CYP11B1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CYP11B1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CYP11B1
     LSBio Antibodies in human, mouse, rat for CYP11B1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CYP11B1 gene at Home site.
    Version: 3.12.136 22 July 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4