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Aliases for CYLC2 Gene

Aliases for CYLC2 Gene

  • Cylicin 2 2 3
  • Cylicin, Basic Protein Of Sperm Head Cytoskeleton 2 2 5
  • Multiple-Band Polypeptide II 4
  • Cylicin II 4
  • CYL2 4

External Ids for CYLC2 Gene

Previous GeneCards Identifiers for CYLC2 Gene

  • GC09P096564
  • GC09P097507
  • GC09P099215
  • GC09P101143
  • GC09P101137
  • GC09P102825
  • GC09P104797
  • GC09P105757
  • GC09P075360

Summaries for CYLC2 Gene

Entrez Gene Summary for CYLC2 Gene

  • Cylicin II (CYCL2) is specifically expressed in testis and is part of the cytoskeletal calyx of mammalian sperm heads. Cylicin II may play a role in the morphogenesis of the sperm head. [provided by RefSeq, Jul 2008]

GeneCards Summary for CYLC2 Gene

CYLC2 (Cylicin 2) is a Protein Coding gene. GO annotations related to this gene include structural constituent of cytoskeleton. An important paralog of this gene is CYLC1.

UniProtKB/Swiss-Prot for CYLC2 Gene

  • Possible architectural role during spermatogenesis. May be involved in spermatid differentiation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYLC2 Gene

Genomics for CYLC2 Gene

Regulatory Elements for CYLC2 Gene

Enhancers for CYLC2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CYLC2 on UCSC Golden Path with GeneCards custom track

Genomic Location for CYLC2 Gene

102,995,311 bp from pter
103,018,488 bp from pter
23,178 bases
Plus strand

Genomic View for CYLC2 Gene

Genes around CYLC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CYLC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CYLC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYLC2 Gene

Proteins for CYLC2 Gene

  • Protein details for CYLC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • B2R8F4
    • Q5VVJ9

    Protein attributes for CYLC2 Gene

    348 amino acids
    Molecular mass:
    39079 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CYLC2 Gene

Proteomics data for CYLC2 Gene at MOPED

Post-translational modifications for CYLC2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CYLC2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CYLC2 Gene

Domains & Families for CYLC2 Gene

Protein Domains for CYLC2 Gene


Suggested Antigen Peptide Sequences for CYLC2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CYLC2: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CYLC2 Gene

Function for CYLC2 Gene

Molecular function for CYLC2 Gene

UniProtKB/Swiss-Prot Function:
Possible architectural role during spermatogenesis. May be involved in spermatid differentiation.
genes like me logo Genes that share phenotypes with CYLC2: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CYLC2 Gene

Localization for CYLC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYLC2 Gene

Cytoplasm, cytoskeleton, perinuclear theca, calyx. Note=Sperm head cytoskeletal structure.

Subcellular locations from

Jensen Localization Image for CYLC2 Gene COMPARTMENTS Subcellular localization image for CYLC2 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for CYLC2 Gene

Pathways & Interactions for CYLC2 Gene

SuperPathways for CYLC2 Gene

No Data Available

Interacting Proteins for CYLC2 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000417674 Q14093-CYLC2_HUMAN for CYLC2 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for CYLC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
genes like me logo Genes that share ontologies with CYLC2: view

No data available for Pathways by source and SIGNOR curated interactions for CYLC2 Gene

Drugs & Compounds for CYLC2 Gene

No Compound Related Data Available

Transcripts for CYLC2 Gene

mRNA/cDNA for CYLC2 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CYLC2 Gene

Cylicin, basic protein of sperm head cytoskeleton 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CYLC2 Gene

No ASD Table

Relevant External Links for CYLC2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CYLC2 Gene

mRNA expression in normal human tissues for CYLC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CYLC2 Gene

This gene is overexpressed in Testis (x52.7).

Protein differential expression in normal tissues from HIPED for CYLC2 Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CYLC2 Gene

SOURCE GeneReport for Unigene cluster for CYLC2 Gene Hs.3232

mRNA Expression by UniProt/SwissProt for CYLC2 Gene

Tissue specificity: Testis.
genes like me logo Genes that share expression patterns with CYLC2: view

Protein tissue co-expression partners for CYLC2 Gene

- Elite partner

Primer Products

Orthologs for CYLC2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CYLC2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CYLC2 35
  • 98.73 (n)
  • 97.14 (a)
CYLC2 36
  • 96 (a)
(Bos Taurus)
Mammalia CYLC2 36
  • 48 (a)
(Canis familiaris)
Mammalia CYLC2 36
  • 38 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 26 (a)
(Mus musculus)
Mammalia Cylc2 36
  • 37 (a)
Species with no ortholog for CYLC2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CYLC2 Gene

Gene Tree for CYLC2 (if available)
Gene Tree for CYLC2 (if available)

Paralogs for CYLC2 Gene

Paralogs for CYLC2 Gene

(1) SIMAP similar genes for CYLC2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CYLC2: view

Variants for CYLC2 Gene

Sequence variations from dbSNP and Humsavar for CYLC2 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs2298050 - 103,005,199(+) ATAAC(A/G)AAAAA reference, missense
rs2298051 - 103,005,254(+) TGAAG(A/G)TGAAA reference, missense
rs3763636 - 103,005,587(+) GGATG(A/C)AAAGA reference, missense
rs13293961 - 103,005,067(+) GCAAG(G/T)ATATA reference, missense
rs10990424 - 103,005,182(+) aggag(A/G)tgcaa reference, missense

Structural Variations from Database of Genomic Variants (DGV) for CYLC2 Gene

Variant ID Type Subtype PubMed ID
nsv893656 CNV Gain 21882294
nsv893657 CNV Loss 21882294
nsv466455 CNV Gain 19166990
nsv516844 CNV Gain+Loss 19592680
nsv893658 CNV Loss 21882294
dgv1363e199 CNV Deletion 23128226
esv2668100 CNV Deletion 23128226
esv21750 CNV Gain 19812545
esv2530008 CNV Loss 19546169
esv2738857 CNV Deletion 23290073
esv2738858 CNV Deletion 23290073
esv2738859 CNV Deletion 23290073
esv4412 CNV Deletion 18987735
nsv415530 CNV Loss 16902084
esv2738860 CNV Deletion 23290073
esv2738861 CNV Deletion 23290073
esv2660397 CNV Deletion 23128226
esv2738863 CNV Deletion 23290073
nsv416206 CNV Loss 16902084

Variation tolerance for CYLC2 Gene

Residual Variation Intolerance Score: 93.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.97; 49.56% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CYLC2 Gene

Disorders for CYLC2 Gene

Relevant External Links for CYLC2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CYLC2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CYLC2 Gene

Publications for CYLC2 Gene

  1. The protein complexity of the cytoskeleton of bovine and human sperm heads: the identification and characterization of cylicin II. (PMID: 7737358) Hess H. … Franke W.W. (Exp. Cell Res. 1995) 2 3 4 23 67
  2. Cross-disorder genome-wide analyses suggest a complex genetic relationship between Tourette's syndrome and OCD. (PMID: 25158072) Yu D. … Pauls D.L. (Am J Psychiatry 2015) 3
  3. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie A.G. … Butte N.F. (PLoS ONE 2012) 3
  4. Proteomic characterization of the human sperm nucleus. (PMID: 21630459) de Mateo S. … Oliva R. (Proteomics 2011) 3
  5. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PMID: 20677014) Shimada M. … Tokunaga K. (Hum. Genet. 2010) 3

Products for CYLC2 Gene

Sources for CYLC2 Gene