Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CYLC2 Gene

Aliases for CYLC2 Gene

  • Cylicin 2 2 3 5
  • Cylicin, Basic Protein Of Sperm Head Cytoskeleton 2 2 3
  • Multiple-Band Polypeptide II 3 4
  • Cylicin II 3 4
  • Cylicin-2 3
  • CYL2 4

External Ids for CYLC2 Gene

Previous GeneCards Identifiers for CYLC2 Gene

  • GC09P096564
  • GC09P097507
  • GC09P099215
  • GC09P101143
  • GC09P101137
  • GC09P102825
  • GC09P104797
  • GC09P105757
  • GC09P075360

Summaries for CYLC2 Gene

Entrez Gene Summary for CYLC2 Gene

  • Cylicin II (CYCL2) is specifically expressed in testis and is part of the cytoskeletal calyx of mammalian sperm heads. Cylicin II may play a role in the morphogenesis of the sperm head. [provided by RefSeq, Jul 2008]

GeneCards Summary for CYLC2 Gene

CYLC2 (Cylicin 2) is a Protein Coding gene. GO annotations related to this gene include structural constituent of cytoskeleton. An important paralog of this gene is CYLC1.

UniProtKB/Swiss-Prot for CYLC2 Gene

  • Possible architectural role during spermatogenesis. May be involved in spermatid differentiation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYLC2 Gene

Genomics for CYLC2 Gene

Regulatory Elements for CYLC2 Gene

Enhancers for CYLC2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09F102971 1.2 FANTOM5 0.3 -23.9 -23869 0.0 CYLC2 LOC100421294
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around CYLC2 on UCSC Golden Path with GeneCards custom track

Genomic Location for CYLC2 Gene

102,995,311 bp from pter
103,018,488 bp from pter
23,178 bases
Plus strand

Genomic View for CYLC2 Gene

Genes around CYLC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CYLC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CYLC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYLC2 Gene

Proteins for CYLC2 Gene

  • Protein details for CYLC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • B2R8F4
    • Q5VVJ9

    Protein attributes for CYLC2 Gene

    348 amino acids
    Molecular mass:
    39079 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CYLC2 Gene

Post-translational modifications for CYLC2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CYLC2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CYLC2 Gene

Domains & Families for CYLC2 Gene

Protein Domains for CYLC2 Gene


Suggested Antigen Peptide Sequences for CYLC2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CYLC2: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CYLC2 Gene

Function for CYLC2 Gene

Molecular function for CYLC2 Gene

UniProtKB/Swiss-Prot Function:
Possible architectural role during spermatogenesis. May be involved in spermatid differentiation.

Gene Ontology (GO) - Molecular Function for CYLC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005200 structural constituent of cytoskeleton IEA --
genes like me logo Genes that share ontologies with CYLC2: view
genes like me logo Genes that share phenotypes with CYLC2: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CYLC2 Gene

Localization for CYLC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYLC2 Gene

Cytoplasm, cytoskeleton, perinuclear theca, calyx. Note=Sperm head cytoskeletal structure.

Subcellular locations from

Jensen Localization Image for CYLC2 Gene COMPARTMENTS Subcellular localization image for CYLC2 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for CYLC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0033150 cytoskeletal calyx IEA --
genes like me logo Genes that share ontologies with CYLC2: view

Pathways & Interactions for CYLC2 Gene

SuperPathways for CYLC2 Gene

No Data Available

Interacting Proteins for CYLC2 Gene

Gene Ontology (GO) - Biological Process for CYLC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007010 cytoskeleton organization IEA --
GO:0007275 multicellular organism development IEA --
GO:0007283 spermatogenesis IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with CYLC2: view

No data available for Pathways by source and SIGNOR curated interactions for CYLC2 Gene

Transcripts for CYLC2 Gene

mRNA/cDNA for CYLC2 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CYLC2 Gene

Cylicin, basic protein of sperm head cytoskeleton 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CYLC2 Gene

No ASD Table

Relevant External Links for CYLC2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CYLC2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CYLC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CYLC2 Gene

This gene is overexpressed in Testis (x52.7).

Protein differential expression in normal tissues from HIPED for CYLC2 Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CYLC2 Gene

Protein tissue co-expression partners for CYLC2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CYLC2 Gene:


SOURCE GeneReport for Unigene cluster for CYLC2 Gene:


mRNA Expression by UniProt/SwissProt for CYLC2 Gene:

Tissue specificity: Testis.
genes like me logo Genes that share expression patterns with CYLC2: view

Primer Products

Orthologs for CYLC2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CYLC2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CYLC2 34 35
  • 98.73 (n)
(Bos Taurus)
Mammalia CYLC2 35
  • 48 (a)
(Canis familiaris)
Mammalia CYLC2 35
  • 38 (a)
(Mus musculus)
Mammalia Cylc2 35
  • 37 (a)
(Monodelphis domestica)
Mammalia -- 35
  • 26 (a)
Species where no ortholog for CYLC2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CYLC2 Gene

Gene Tree for CYLC2 (if available)
Gene Tree for CYLC2 (if available)

Paralogs for CYLC2 Gene

Paralogs for CYLC2 Gene

(1) SIMAP similar genes for CYLC2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CYLC2: view

Variants for CYLC2 Gene

Sequence variations from dbSNP and Humsavar for CYLC2 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs10115462 -- 102,996,380(+) TATCA(C/T)GAGCA intron-variant
rs10115583 -- 102,996,095(+) GTGGG(A/C)CTTAA intron-variant
rs10119363 -- 102,998,497(+) GAGAT(A/G)CTCTC intron-variant
rs10119488 -- 103,006,221(+) AAATA(C/T)AGCAT utr-variant-3-prime
rs10119620 -- 103,006,146(+) TGCAT(A/C)CACAG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CYLC2 Gene

Variant ID Type Subtype PubMed ID
dgv1363e199 CNV deletion 23128226
dgv4111n106 CNV deletion 24896259
dgv7692n100 CNV loss 25217958
dgv7693n100 CNV loss 25217958
esv21750 CNV gain 19812545
esv2530008 CNV loss 19546169
esv2660397 CNV deletion 23128226
esv2668100 CNV deletion 23128226
esv2738857 CNV deletion 23290073
esv2738858 CNV deletion 23290073
esv2738859 CNV deletion 23290073
esv2738860 CNV deletion 23290073
esv2738861 CNV deletion 23290073
esv2738863 CNV deletion 23290073
esv2762824 CNV loss 21179565
esv3573326 CNV loss 25503493
esv3576687 CNV gain 25503493
esv3621296 CNV loss 21293372
esv3621301 CNV loss 21293372
esv4412 CNV loss 18987735
nsv1036220 CNV loss 25217958
nsv1043424 CNV loss 25217958
nsv1051679 CNV loss 25217958
nsv1051901 CNV loss 25217958
nsv1075667 CNV deletion 25765185
nsv1075668 CNV deletion 25765185
nsv1128336 CNV deletion 24896259
nsv1134928 CNV tandem duplication 24896259
nsv1141018 CNV deletion 24896259
nsv415530 CNV deletion 16902084
nsv416206 CNV deletion 16902084
nsv466455 CNV gain 19166990
nsv516844 CNV gain+loss 19592680
nsv615027 CNV gain 21841781
nsv615037 CNV loss 21841781
nsv615038 CNV loss 21841781
nsv615039 CNV loss 21841781

Variation tolerance for CYLC2 Gene

Residual Variation Intolerance Score: 93.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.97; 49.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CYLC2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CYLC2 Gene

Disorders for CYLC2 Gene

Relevant External Links for CYLC2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CYLC2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CYLC2 Gene

Publications for CYLC2 Gene

  1. The protein complexity of the cytoskeleton of bovine and human sperm heads: the identification and characterization of cylicin II. (PMID: 7737358) Hess H. … Franke W.W. (Exp. Cell Res. 1995) 2 3 4 22 64
  2. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PMID: 20677014) Shimada M. … Tokunaga K. (Hum. Genet. 2010) 3 46 64
  3. Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts. (PMID: 18978678) Vieira A.R. … Marazita M.L. (Genet. Med. 2008) 3 46 64
  4. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for CYLC2 Gene

Sources for CYLC2 Gene

Loading form....