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Aliases for CYLC2 Gene

Aliases for CYLC2 Gene

  • Cylicin, Basic Protein Of Sperm Head Cytoskeleton 2 2 3
  • Multiple-Band Polypeptide II 3 4
  • Cylicin II 3 4
  • Cylicin-2 3
  • CYL2 4

External Ids for CYLC2 Gene

Summaries for CYLC2 Gene

Entrez Gene Summary for CYLC2 Gene

  • Cylicin II (CYCL2) is specifically expressed in testis and is part of the cytoskeletal calyx of mammalian sperm heads. Cylicin II may play a role in the morphogenesis of the sperm head. [provided by RefSeq, Jul 2008]

GeneCards Summary for CYLC2 Gene

CYLC2 (Cylicin, Basic Protein Of Sperm Head Cytoskeleton 2) is a Protein Coding gene. GO annotations related to this gene include structural constituent of cytoskeleton. An important paralog of this gene is CYLC1.

UniProtKB/Swiss-Prot for CYLC2 Gene

  • Possible architectural role during spermatogenesis. May be involved in spermatid differentiation

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYLC2 Gene

Genomics for CYLC2 Gene

Genomic Location for CYLC2 Gene

Start:
102,995,311 bp from pter
End:
103,018,488 bp from pter
Size:
23,178 bases
Orientation:
Plus strand

Genomic View for CYLC2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CYLC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYLC2 Gene

Regulatory Elements for CYLC2 Gene

Proteins for CYLC2 Gene

  • Protein details for CYLC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14093-CYLC2_HUMAN
    Recommended name:
    Cylicin-2
    Protein Accession:
    Q14093
    Secondary Accessions:
    • B2R8F4
    • Q5VVJ9

    Protein attributes for CYLC2 Gene

    Size:
    348 amino acids
    Molecular mass:
    39079 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CYLC2 Gene

Proteomics data for CYLC2 Gene at MOPED

Post-translational modifications for CYLC2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CYLC2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CYLC2 Gene

Domains for CYLC2 Gene

Protein Domains for CYLC2 Gene

InterPro:
ProtoNet:
genes like me logo Genes that share domains with CYLC2: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CYLC2 Gene

Function for CYLC2 Gene

Molecular function for CYLC2 Gene

UniProtKB/Swiss-Prot Function: Possible architectural role during spermatogenesis. May be involved in spermatid differentiation

Gene Ontology (GO) - Molecular Function for CYLC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005200 structural constituent of cytoskeleton IEA --
genes like me logo Genes that share ontologies with CYLC2: view

Phenotypes for CYLC2 Gene

GenomeRNAi human phenotypes for CYLC2:
genes like me logo Genes that share phenotypes with CYLC2: view

miRNA for CYLC2 Gene

miRTarBase miRNAs that target CYLC2

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CYLC2 Gene

Localization for CYLC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYLC2 Gene

Cytoplasm, cytoskeleton, perinuclear theca, calyx. Note=Sperm head cytoskeletal structure.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CYLC2 Gene COMPARTMENTS Subcellular localization image for CYLC2 gene
Compartment Confidence
cytoskeleton 5
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for CYLC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005737 cytoplasm --
GO:0005856 cytoskeleton --
GO:0033150 cytoskeletal calyx IEA --
genes like me logo Genes that share ontologies with CYLC2: view

Pathways for CYLC2 Gene

SuperPathways for CYLC2 Gene

No Data Available

Interacting Proteins for CYLC2 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000417674%0d%0a9606.ENSP00000254942%0d%0a9606.ENSP00000350249%0d%0a
Selected Interacting proteins: ENSP00000417674 Q14093-CYLC2_HUMAN for CYLC2 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for CYLC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organismal development IEA --
GO:0007283 spermatogenesis IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with CYLC2: view

No data available for Pathways by source for CYLC2 Gene

Transcripts for CYLC2 Gene

mRNA/cDNA for CYLC2 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CYLC2 Gene

Cylicin, basic protein of sperm head cytoskeleton 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CYLC2 Gene

No ASD Table

Relevant External Links for CYLC2 Gene

GeneLoc Exon Structure for
CYLC2
ECgene alternative splicing isoforms for
CYLC2

Expression for CYLC2 Gene

mRNA expression in normal human tissues for CYLC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CYLC2 Gene

This gene is overexpressed in Testis (52.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CYLC2 Gene

SOURCE GeneReport for Unigene cluster for CYLC2 Gene Hs.3232

mRNA Expression by UniProt/SwissProt for CYLC2 Gene

Q14093-CYLC2_HUMAN
Tissue specificity: Testis
genes like me logo Genes that share expressions with CYLC2: view

Orthologs for CYLC2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CYLC2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CYLC2 36
  • 98.73 (n)
  • 97.14 (a)
CYLC2 37
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CYLC2 37
  • 48 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CYLC2 37
  • 38 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cylc2 16
Cylc2 37
  • 37 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 26 (a)
OneToMany
Species with no ortholog for CYLC2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CYLC2 Gene

ENSEMBL:
Gene Tree for CYLC2 (if available)
TreeFam:
Gene Tree for CYLC2 (if available)

Paralogs for CYLC2 Gene

Paralogs for CYLC2 Gene

Selected SIMAP similar genes for CYLC2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CYLC2: view

Variants for CYLC2 Gene

Sequence variations from dbSNP and Humsavar for CYLC2 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs874794 -- 103,007,154(+) ATGAA(C/G)TTTGG intron-variant
rs947186 -- 103,007,876(-) ATGTT(A/G)AGTGT intron-variant
rs947187 -- 103,007,756(-) AGTTT(A/G)TGTCA intron-variant
rs947188 -- 103,007,386(-) CTTGT(C/T)GGTAA intron-variant
rs1107538 -- 103,008,274(+) GGTGC(A/G)CCATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CYLC2 Gene

Variant ID Type Subtype PubMed ID
nsv893656 CNV Gain 21882294
nsv893657 CNV Loss 21882294
nsv466455 CNV Gain 19166990
nsv516844 CNV Gain+Loss 19592680
nsv893658 CNV Loss 21882294
dgv1363e199 CNV Deletion 23128226
esv2668100 CNV Deletion 23128226
esv21750 CNV Gain 19812545
esv2530008 CNV Loss 19546169
esv2738857 CNV Deletion 23290073
esv2738858 CNV Deletion 23290073
esv2738859 CNV Deletion 23290073
esv4412 CNV Deletion 18987735
nsv415530 CNV Loss 16902084
esv2738860 CNV Deletion 23290073
esv2738861 CNV Deletion 23290073
esv2660397 CNV Deletion 23128226
esv2738863 CNV Deletion 23290073
nsv416206 CNV Loss 16902084

Relevant External Links for CYLC2 Gene

HapMap Linkage Disequilibrium report
CYLC2

Disorders for CYLC2 Gene

Relevant External Links for CYLC2

Genetic Association Database (GAD)
CYLC2
Human Genome Epidemiology (HuGE) Navigator
CYLC2
genes like me logo Genes that share disorders with CYLC2: view

No data available for UniProtKB/Swiss-Prot for CYLC2 Gene

Publications for CYLC2 Gene

  1. The protein complexity of the cytoskeleton of bovine and human sperm heads: the identification and characterization of cylicin II. (PMID: 7737358) Hess H. … Franke W.W. (Exp. Cell Res. 1995) 2 3 4 23
  2. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts. (PMID: 18978678) Vieira A.R. … Marazita M.L. (Genet. Med. 2008) 3 49
  5. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PMID: 20677014) Shimada M. … Tokunaga K. (Hum. Genet. 2010) 3 49

Products for CYLC2 Gene

Sources for CYLC2 Gene

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