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Aliases for CYLC1 Gene

Aliases for CYLC1 Gene

  • Cylicin 1 2 3
  • Cylicin, Basic Protein Of Sperm Head Cytoskeleton 1 2 3 5
  • Multiple-Band Polypeptide I 3 4
  • Cylicin I 3 4
  • CYCL1 3
  • CYL1 4
  • CYL 4

External Ids for CYLC1 Gene

Previous GeneCards Identifiers for CYLC1 Gene

  • GC0XP078495
  • GC0XP080192
  • GC0XP081163
  • GC0XP081888
  • GC0XP082922
  • GC0XP083116
  • GC0XP076689

Summaries for CYLC1 Gene

Entrez Gene Summary for CYLC1 Gene

  • This gene encodes a sperm head cytoskeletal protein. The encoded protein is associated with the calyx of spermatozoa and spermatids. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]

GeneCards Summary for CYLC1 Gene

CYLC1 (Cylicin 1) is a Protein Coding gene. Diseases associated with CYLC1 include ametropic amblyopia and astigmatism. GO annotations related to this gene include structural molecule activity and structural constituent of cytoskeleton. An important paralog of this gene is CYLC2.

UniProtKB/Swiss-Prot for CYLC1 Gene

  • Possible architectural role during spermatogenesis. May be involved in spermatid differentiation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYLC1 Gene

Genomics for CYLC1 Gene

Regulatory Elements for CYLC1 Gene

Genomic Location for CYLC1 Gene

Chromosome:
X
Start:
83,861,126 bp from pter
End:
83,886,700 bp from pter
Size:
25,575 bases
Orientation:
Plus strand

Genomic View for CYLC1 Gene

Genes around CYLC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CYLC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CYLC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYLC1 Gene

Proteins for CYLC1 Gene

  • Protein details for CYLC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P35663-CYLC1_HUMAN
    Recommended name:
    Cylicin-1
    Protein Accession:
    P35663
    Secondary Accessions:
    • A0AVQ8
    • Q5JQQ9

    Protein attributes for CYLC1 Gene

    Size:
    651 amino acids
    Molecular mass:
    74242 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CYLC1 Gene

Proteomics data for CYLC1 Gene at MOPED

Post-translational modifications for CYLC1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CYLC1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CYLC1 Gene

Domains & Families for CYLC1 Gene

Protein Domains for CYLC1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CYLC1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CYLC1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CYLC1 Gene

Function for CYLC1 Gene

Molecular function for CYLC1 Gene

UniProtKB/Swiss-Prot Function:
Possible architectural role during spermatogenesis. May be involved in spermatid differentiation.
genes like me logo Genes that share phenotypes with CYLC1: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CYLC1 Gene

Localization for CYLC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYLC1 Gene

Cytoplasm, cytoskeleton, perinuclear theca, calyx. Note=Sperm head cytoskeletal structure.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CYLC1 Gene COMPARTMENTS Subcellular localization image for CYLC1 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
vacuole 5
cytosol 2

Gene Ontology (GO) - Cellular Components for CYLC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043159 acrosomal matrix IDA 8354692
genes like me logo Genes that share ontologies with CYLC1: view

Pathways & Interactions for CYLC1 Gene

SuperPathways for CYLC1 Gene

No Data Available

Interacting Proteins for CYLC1 Gene

Gene Ontology (GO) - Biological Process for CYLC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
genes like me logo Genes that share ontologies with CYLC1: view

No data available for Pathways by source and SIGNOR curated interactions for CYLC1 Gene

Drugs & Compounds for CYLC1 Gene

(1) Additional Compounds for CYLC1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CYLC1: view

Transcripts for CYLC1 Gene

mRNA/cDNA for CYLC1 Gene

(3) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(13) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CYLC1 Gene

Cylicin, basic protein of sperm head cytoskeleton 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CYLC1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6
SP1:
SP2:
SP3: - - - - -
SP4: -
SP5: -
SP6:

Relevant External Links for CYLC1 Gene

GeneLoc Exon Structure for
CYLC1
ECgene alternative splicing isoforms for
CYLC1

Expression for CYLC1 Gene

mRNA expression in normal human tissues for CYLC1 Gene

mRNA differential expression in normal tissues according to GTEx for CYLC1 Gene

This gene is overexpressed in Testis (x52.7).

Protein differential expression in normal tissues from HIPED for CYLC1 Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CYLC1 Gene



SOURCE GeneReport for Unigene cluster for CYLC1 Gene Hs.444230

mRNA Expression by UniProt/SwissProt for CYLC1 Gene

P35663-CYLC1_HUMAN
Tissue specificity: Testis.
genes like me logo Genes that share expression patterns with CYLC1: view

Protein tissue co-expression partners for CYLC1 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for CYLC1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CYLC1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CYLC1 35
  • 76.7 (n)
  • 61.49 (a)
CYLC1 36
  • 57 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CYLC1 35
  • 74.33 (n)
  • 55.67 (a)
CYLC1 36
  • 58 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CYLC1 35
  • 98.92 (n)
  • 98.3 (a)
CYLC1 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 24 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Cylc1 36
  • 39 (a)
OneToOne
Species with no ortholog for CYLC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CYLC1 Gene

ENSEMBL:
Gene Tree for CYLC1 (if available)
TreeFam:
Gene Tree for CYLC1 (if available)

Paralogs for CYLC1 Gene

Paralogs for CYLC1 Gene

(1) SIMAP similar genes for CYLC1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CYLC1: view

Variants for CYLC1 Gene

Sequence variations from dbSNP and Humsavar for CYLC1 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs12008888 - 83,873,903(+) AAAAG(C/G)ATGCA intron-variant, reference, missense
rs4581195 -- 83,884,432(+) GTTTA(A/G)TTAAG intron-variant
rs5921999 -- 83,860,730(+) GTACA(A/T)AAAGG upstream-variant-2KB
rs5922000 -- 83,864,931(+) tagcc(C/T)aaaaa intron-variant
rs5922001 -- 83,875,194(+) GAAAT(A/G)ACTAT intron-variant

Variation tolerance for CYLC1 Gene

Residual Variation Intolerance Score: 98.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.71; 57.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CYLC1 Gene

HapMap Linkage Disequilibrium report
CYLC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CYLC1 Gene

Disorders for CYLC1 Gene

MalaCards: The human disease database

(4) MalaCards diseases for CYLC1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
ametropic amblyopia
  • refractive amblyopia
astigmatism
regular astigmatism
punctate epithelial keratoconjunctivitis
  • punctate keratitis
- elite association - COSMIC cancer census association via MalaCards
Search CYLC1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CYLC1

Genetic Association Database (GAD)
CYLC1
Human Genome Epidemiology (HuGE) Navigator
CYLC1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CYLC1
genes like me logo Genes that share disorders with CYLC1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CYLC1 Gene

Publications for CYLC1 Gene

  1. Molecular characterization of mammalian cylicin, a basic protein of the sperm head cytoskeleton. (PMID: 8354692) Hess H. … Franke W.W. (J. Cell Biol. 1993) 2 3 4 23 67
  2. The protein complexity of the cytoskeleton of bovine and human sperm heads: the identification and characterization of cylicin II. (PMID: 7737358) Hess H. … Franke W.W. (Exp. Cell Res. 1995) 2 3 23
  3. Proteomic characterization of the human sperm nucleus. (PMID: 21630459) de Mateo S. … Oliva R. (Proteomics 2011) 3
  4. X chromosomal variation is associated with slow progression to AIDS in HIV-1-infected women. (PMID: 19679225) Siddiqui R.A. … Platzer M. (Am. J. Hum. Genet. 2009) 3
  5. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3

Products for CYLC1 Gene

Sources for CYLC1 Gene

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