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Aliases for CYLC1 Gene

Aliases for CYLC1 Gene

  • Cylicin, Basic Protein Of Sperm Head Cytoskeleton 1 2 3
  • Multiple-Band Polypeptide I 3 4
  • Cylicin I 3 4
  • Cylicin 1 2
  • Cylicin-1 3
  • CYCL1 3
  • CYL1 4
  • CYL 4

External Ids for CYLC1 Gene

Previous GeneCards Identifiers for CYLC1 Gene

  • GC0XP078495
  • GC0XP080192
  • GC0XP081163
  • GC0XP081888
  • GC0XP082922
  • GC0XP083116
  • GC0XP076689

Summaries for CYLC1 Gene

Entrez Gene Summary for CYLC1 Gene

  • This gene encodes a sperm head cytoskeletal protein. The encoded protein is associated with the calyx of spermatozoa and spermatids. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]

GeneCards Summary for CYLC1 Gene

CYLC1 (Cylicin, Basic Protein Of Sperm Head Cytoskeleton 1) is a Protein Coding gene. GO annotations related to this gene include structural molecule activity and structural constituent of cytoskeleton. An important paralog of this gene is CYLC2.

UniProtKB/Swiss-Prot for CYLC1 Gene

  • Possible architectural role during spermatogenesis. May be involved in spermatid differentiation

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYLC1 Gene

Genomics for CYLC1 Gene

Regulatory Elements for CYLC1 Gene

Genomic Location for CYLC1 Gene

Start:
83,861,126 bp from pter
End:
83,886,700 bp from pter
Size:
25,575 bases
Orientation:
Plus strand

Genomic View for CYLC1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CYLC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYLC1 Gene

Proteins for CYLC1 Gene

  • Protein details for CYLC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P35663-CYLC1_HUMAN
    Recommended name:
    Cylicin-1
    Protein Accession:
    P35663
    Secondary Accessions:
    • A0AVQ8
    • Q5JQQ9

    Protein attributes for CYLC1 Gene

    Size:
    651 amino acids
    Molecular mass:
    74242 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CYLC1 Gene

Proteomics data for CYLC1 Gene at MOPED

Post-translational modifications for CYLC1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CYLC1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for CYLC1 Gene

Domains for CYLC1 Gene

Protein Domains for CYLC1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CYLC1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CYLC1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CYLC1 Gene

Function for CYLC1 Gene

Molecular function for CYLC1 Gene

UniProtKB/Swiss-Prot Function:
Possible architectural role during spermatogenesis. May be involved in spermatid differentiation

Gene Ontology (GO) - Molecular Function for CYLC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity NAS 8354692
GO:0005200 structural constituent of cytoskeleton IEA --
genes like me logo Genes that share ontologies with CYLC1: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CYLC1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CYLC1 Gene

Localization for CYLC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYLC1 Gene

Cytoplasm, cytoskeleton, perinuclear theca, calyx. Note=Sperm head cytoskeletal structure.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CYLC1 Gene COMPARTMENTS Subcellular localization image for CYLC1 gene
Compartment Confidence
cytoskeleton 5
vacuole 5
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for CYLC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005856 cytoskeleton --
GO:0033150 cytoskeletal calyx IEA --
GO:0043159 acrosomal matrix IDA 8354692
genes like me logo Genes that share ontologies with CYLC1: view

Pathways for CYLC1 Gene

SuperPathways for CYLC1 Gene

No Data Available

Interacting Proteins for CYLC1 Gene

Gene Ontology (GO) - Biological Process for CYLC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organismal development IEA --
GO:0007283 spermatogenesis NAS 8354692
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with CYLC1: view

No data available for Pathways by source for CYLC1 Gene

Compounds for CYLC1 Gene

(1) Novoseek inferred chemical compound relationships for CYLC1 Gene

Compound -log(P) Hits PubMed IDs
tripeptide s 77.5 3
genes like me logo Genes that share compounds with CYLC1: view

Transcripts for CYLC1 Gene

mRNA/cDNA for CYLC1 Gene

(13) Selected AceView cDNA sequences:
(6) Additional mRNA sequences :
(3) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CYLC1 Gene

Cylicin, basic protein of sperm head cytoskeleton 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CYLC1

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CYLC1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6
SP1:
SP2:
SP3: - - - - -
SP4: -
SP5: -
SP6:

Relevant External Links for CYLC1 Gene

GeneLoc Exon Structure for
CYLC1
ECgene alternative splicing isoforms for
CYLC1

Expression for CYLC1 Gene

mRNA expression in normal human tissues for CYLC1 Gene

mRNA differential expression in normal tissues according to GTEx for CYLC1 Gene

This gene is overexpressed in Testis (52.7).

Protein differential expression in normal tissues for CYLC1 Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for CYLC1 Gene

SOURCE GeneReport for Unigene cluster for CYLC1 Gene Hs.444230

mRNA Expression by UniProt/SwissProt for CYLC1 Gene

P35663-CYLC1_HUMAN
Tissue specificity: Testis
genes like me logo Genes that share expressions with CYLC1: view

Expression partners for CYLC1 Gene

In Situ Assay Products

Orthologs for CYLC1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CYLC1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CYLC1 35
  • 76.7 (n)
  • 61.49 (a)
CYLC1 36
  • 57 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CYLC1 35
  • 74.33 (n)
  • 55.67 (a)
CYLC1 36
  • 58 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CYLC1 35
  • 98.92 (n)
  • 98.3 (a)
CYLC1 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cylc1 16
Cylc1 36
  • 39 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 24 (a)
OneToMany
Species with no ortholog for CYLC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CYLC1 Gene

ENSEMBL:
Gene Tree for CYLC1 (if available)
TreeFam:
Gene Tree for CYLC1 (if available)

Paralogs for CYLC1 Gene

Paralogs for CYLC1 Gene

Selected SIMAP similar genes for CYLC1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CYLC1: view

Variants for CYLC1 Gene

Sequence variations from dbSNP and Humsavar for CYLC1 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs4581195 -- 83,884,432(+) GTTTA(A/G)TTAAG intron-variant
rs5921999 -- 83,860,730(+) GTACA(A/T)AAAGG upstream-variant-2KB
rs5922000 -- 83,864,931(+) tagcc(C/T)aaaaa intron-variant
rs5922001 -- 83,875,194(+) GAAAT(A/G)ACTAT intron-variant
rs5922880 -- 83,868,561(+) ctgag(A/G)ctgat intron-variant

Relevant External Links for CYLC1 Gene

HapMap Linkage Disequilibrium report
CYLC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CYLC1 Gene

Disorders for CYLC1 Gene

Relevant External Links for CYLC1

Genetic Association Database (GAD)
CYLC1
Human Genome Epidemiology (HuGE) Navigator
CYLC1

No disorders were found for CYLC1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for CYLC1 Gene

Publications for CYLC1 Gene

  1. Molecular characterization of mammalian cylicin, a basic protein of the sperm head cytoskeleton. (PMID: 8354692) Hess H. … Franke W.W. (J. Cell Biol. 1993) 2 3 4 23
  2. The protein complexity of the cytoskeleton of bovine and human sperm heads: the identification and characterization of cylicin II. (PMID: 7737358) Hess H. … Franke W.W. (Exp. Cell Res. 1995) 2 3 23
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4
  5. X chromosomal variation is associated with slow progression to AIDS in HIV-1-infected women. (PMID: 19679225) Siddiqui R.A. … Platzer M. (Am. J. Hum. Genet. 2009) 3 48

Products for CYLC1 Gene

Sources for CYLC1 Gene

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