Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CYHR1 Gene

Aliases for CYHR1 Gene

  • Cysteine And Histidine Rich 1 2 3 5
  • Cysteine/Histidine-Rich 1 2 3
  • Cysteine And Histidine-Rich Protein 1 3
  • Cysteine And Histidine Rich Protein 3
  • KIAA0496 4
  • CHRP 3

External Ids for CYHR1 Gene

Previous GeneCards Identifiers for CYHR1 Gene

  • GC08U990106
  • GC08M145646
  • GC08M145660
  • GC08M140788
  • GC08M145674

Summaries for CYHR1 Gene

GeneCards Summary for CYHR1 Gene

CYHR1 (Cysteine And Histidine Rich 1) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYHR1 Gene

Genomics for CYHR1 Gene

Regulatory Elements for CYHR1 Gene

Enhancers for CYHR1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08G143493 2.4 Ensembl ENCODE dbSUPER 10.1 +971.2 971234 2.6 HDAC1 CBX3 ARNT ARID4B SIN3A DMAP1 ZNF2 RAD21 GLIS2 ELK1 ENSG00000254859 JRK ZNF696 ZNF623 CYHR1 VPS28 ZC3H3 GC08P143506 PIR44330
GH08G143914 2.2 FANTOM5 Ensembl ENCODE dbSUPER 10.1 +528.6 528561 45.2 CREB3L1 MLX AGO1 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF263 PLEC ZNF251 ZNF517 ZNF250 LOC105375803 LRRC14 ZNF696 ZNF34 ZNF623 CYHR1
GH08G143731 1.7 FANTOM5 ENCODE dbSUPER 10.1 +728.4 728444 11.1 HDGF PKNOX1 CREB3L1 AGO1 SIN3A ARID4B ZBTB7B ZNF143 ZNF207 FOS ENSG00000254548 FAM83H-AS1 LRRC14 FAM83H LOC105375803 ZNF696 ZNF623 CYHR1 VPS28 ENSG00000254973
GH08G144506 1.4 ENCODE dbSUPER 10.3 -43.3 -43279 4.0 HNRNPUL1 HDGF PKNOX1 ARNT CREB3L1 AGO1 ARID4B SIN3A DMAP1 ZNF2 ZNF251 LRRC14 ZNF250 VPS28 PPP1R16A ZNF623 LOC105375803 ENSG00000254533 ZNF517 TMED10P1
GH08G144407 1.4 ENCODE dbSUPER 10.3 +55.5 55522 4.8 HDGF HNRNPUL1 FOXA2 CREB3L1 ARNT AGO1 ZFP64 ARID4B SIN3A DMAP1 ZNF251 CPSF1 ZNF517 ZNF250 LOC105375803 LRRC14 TMED10P1 ENSG00000255164 ZNF34 ZNF623
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CYHR1 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the CYHR1 gene promoter:

Genomic Location for CYHR1 Gene

Chromosome:
8
Start:
144,449,582 bp from pter
End:
144,465,691 bp from pter
Size:
16,110 bases
Orientation:
Minus strand

Genomic View for CYHR1 Gene

Genes around CYHR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CYHR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CYHR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYHR1 Gene

Proteins for CYHR1 Gene

  • Protein details for CYHR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZMK1-CYHR1_HUMAN
    Recommended name:
    Cysteine and histidine-rich protein 1
    Protein Accession:
    Q6ZMK1
    Secondary Accessions:
    • B3KSX0
    • D3DWM3
    • Q9BSF6
    • Q9BSU6

    Protein attributes for CYHR1 Gene

    Size:
    362 amino acids
    Molecular mass:
    40703 Da
    Quaternary structure:
    • Interacts with LGALS3.
    SequenceCaution:
    • Sequence=BAD18724.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CYHR1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CYHR1 Gene

Post-translational modifications for CYHR1 Gene

  • Ubiquitination at Lys104, isoforms=2292, and isoforms=2349
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CYHR1 Gene

Domains & Families for CYHR1 Gene

Protein Domains for CYHR1 Gene

Suggested Antigen Peptide Sequences for CYHR1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6ZMK1

UniProtKB/Swiss-Prot:

CYHR1_HUMAN :
  • Belongs to the CYHR1 family.
Family:
  • Belongs to the CYHR1 family.
genes like me logo Genes that share domains with CYHR1: view

No data available for Gene Families for CYHR1 Gene

Function for CYHR1 Gene

Gene Ontology (GO) - Molecular Function for CYHR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with CYHR1: view

Phenotypes for CYHR1 Gene

genes like me logo Genes that share phenotypes with CYHR1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CYHR1 Gene

Localization for CYHR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYHR1 Gene

Cytoplasm. Cytoplasm, perinuclear region. Note=Shows a prominent perinuclear and cytoplasmic localization. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CYHR1 gene
Compartment Confidence
nucleus 5
extracellular 2
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for CYHR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0048471 perinuclear region of cytoplasm IEA --
genes like me logo Genes that share ontologies with CYHR1: view

Pathways & Interactions for CYHR1 Gene

SuperPathways for CYHR1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CYHR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with CYHR1: view

No data available for Pathways by source and SIGNOR curated interactions for CYHR1 Gene

Drugs & Compounds for CYHR1 Gene

No Compound Related Data Available

Transcripts for CYHR1 Gene

Unigene Clusters for CYHR1 Gene

Cysteine/histidine-rich 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for CYHR1 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3a · 3b ^ 4a · 4b · 4c · 4d · 4e · 4f ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b
SP1: - - - - - -
SP2: - - - - - - - - - -
SP3: - -
SP4: - - - - - -
SP5: - -
SP6: -
SP7:
SP8: -
SP9:
SP10:
SP11: -

Relevant External Links for CYHR1 Gene

GeneLoc Exon Structure for
CYHR1
ECgene alternative splicing isoforms for
CYHR1

Expression for CYHR1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CYHR1 Gene

Protein differential expression in normal tissues from HIPED for CYHR1 Gene

This gene is overexpressed in Testis (13.6), Fetal Brain (9.7), Retina (8.6), Fetal ovary (6.4), and Islet of Langerhans (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CYHR1 Gene



Protein tissue co-expression partners for CYHR1 Gene

NURSA nuclear receptor signaling pathways regulating expression of CYHR1 Gene:

CYHR1

SOURCE GeneReport for Unigene cluster for CYHR1 Gene:

Hs.459379

Evidence on tissue expression from TISSUES for CYHR1 Gene

  • Nervous system(4.7)
  • Lung(4.3)
  • Spleen(4.2)
genes like me logo Genes that share expression patterns with CYHR1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CYHR1 Gene

Orthologs for CYHR1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CYHR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CYHR1 34 35
  • 99.3 (n)
cow
(Bos Taurus)
Mammalia CYHR1 34 35
  • 93.55 (n)
dog
(Canis familiaris)
Mammalia CYHR1 34 35
  • 91.44 (n)
oppossum
(Monodelphis domestica)
Mammalia CYHR1 35
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CYHR1 35
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cyhr1 34 16 35
  • 89.82 (n)
rat
(Rattus norvegicus)
Mammalia Cyhr1 34
  • 85.97 (n)
lizard
(Anolis carolinensis)
Reptilia CYHR1 35
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101735269 34
  • 82.63 (n)
zebrafish
(Danio rerio)
Actinopterygii cyhr1 34 35
  • 78.61 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG32486 34 35
  • 58.59 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002264 34
  • 58.25 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8507 35
  • 44 (a)
OneToOne
Species where no ortholog for CYHR1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CYHR1 Gene

ENSEMBL:
Gene Tree for CYHR1 (if available)
TreeFam:
Gene Tree for CYHR1 (if available)

Paralogs for CYHR1 Gene

No data available for Paralogs for CYHR1 Gene

Variants for CYHR1 Gene

Sequence variations from dbSNP and Humsavar for CYHR1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1000026052 -- 144,459,645(+) TGGAT(A/G)ACAAG intron-variant
rs1000209806 -- 144,462,357(+) CAGTT(C/T)CCCGC intron-variant, reference, missense
rs1000336116 -- 144,462,617(+) CCGCG(A/G)CCGGG intron-variant, reference, missense
rs1000379339 -- 144,455,239(+) GAACC(C/T)GGGAG intron-variant, utr-variant-5-prime
rs1000393001 -- 144,466,237(+) TCCAG(A/G)TGCGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CYHR1 Gene

Variant ID Type Subtype PubMed ID
dgv12434n54 CNV loss 21841781
dgv12438n54 CNV loss 21841781
dgv12439n54 CNV loss 21841781
dgv12440n54 CNV loss 21841781
dgv3934n106 CNV deletion 24896259
dgv907n27 CNV loss 19166990
esv1003467 CNV deletion 20482838
esv26548 CNV gain 19812545
esv2759652 CNV gain+loss 17122850
esv29999 CNV loss 17803354
nsv1077078 CNV deletion 25765185
nsv1077079 CNV deletion 25765185
nsv1144242 CNV deletion 24896259
nsv428208 CNV gain 18775914
nsv470249 CNV loss 18288195
nsv515809 CNV gain+loss 19592680
nsv612935 CNV loss 21841781
nsv612936 CNV loss 21841781
nsv612940 CNV loss 21841781
nsv612946 CNV loss 21841781
nsv612947 CNV loss 21841781
nsv831489 CNV loss 17160897

Variation tolerance for CYHR1 Gene

Gene Damage Index Score: 0.38; 8.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CYHR1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CYHR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CYHR1 Gene

Disorders for CYHR1 Gene

Relevant External Links for CYHR1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CYHR1

No disorders were found for CYHR1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CYHR1 Gene

Publications for CYHR1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. Interaction of a novel cysteine and histidine-rich cytoplasmic protein with galectin-3 in a carbohydrate-independent manner. (PMID: 10745073) Menon R.P. … Hughes R.C. (FEBS Lett. 2000) 2 3 64
  3. Characterization of cDNA clones in size-fractionated cDNA libraries from human brain. (PMID: 9455484) Seki N. … Ohara O. (DNA Res. 1997) 3 4 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64

Products for CYHR1 Gene

Sources for CYHR1 Gene

Content
Loading form....