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Aliases for CYHR1 Gene

Aliases for CYHR1 Gene

  • Cysteine/Histidine-Rich 1 2 3
  • Cysteine And Histidine Rich 1 2 3
  • Cysteine And Histidine-Rich Protein 1 3
  • Cysteine And Histidine Rich Protein 3
  • KIAA0496 4
  • CHRP 3

External Ids for CYHR1 Gene

Summaries for CYHR1 Gene

GeneCards Summary for CYHR1 Gene

CYHR1 (Cysteine/Histidine-Rich 1) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYHR1 Gene

Genomics for CYHR1 Gene

Genomic Location for CYHR1 Gene

Start:
144,449,582 bp from pter
End:
144,465,678 bp from pter
Size:
16,097 bases
Orientation:
Minus strand

Genomic View for CYHR1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CYHR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYHR1 Gene

Regulatory Elements for CYHR1 Gene

Transcription factor binding sites by QIAGEN in the CYHR1 gene promoter:

Proteins for CYHR1 Gene

  • Protein details for CYHR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZMK1-CYHR1_HUMAN
    Recommended name:
    Cysteine and histidine-rich protein 1
    Protein Accession:
    Q6ZMK1
    Secondary Accessions:
    • B3KSX0
    • D3DWM3
    • Q9BSF6
    • Q9BSU6

    Protein attributes for CYHR1 Gene

    Size:
    362 amino acids
    Molecular mass:
    40703 Da
    Quaternary structure:
    • Interacts with LGALS3.
    SequenceCaution:
    • Sequence=BAD18724.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CYHR1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CYHR1 Gene

Proteomics data for CYHR1 Gene at MOPED

Post-translational modifications for CYHR1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys104, Lys292, and Lys349

No data available for DME Specific Peptides for CYHR1 Gene

Domains for CYHR1 Gene

Protein Domains for CYHR1 Gene

UniProtKB/Swiss-Prot:

CYHR1_HUMAN
Family:
  • Belongs to the CYHR1 family.:
    • Q6ZMK1
Similarity:
  • Contains 1 RING-type zinc finger.:
    • Q6ZMK1
  • Contains 1 TRAF-type zinc finger.:
    • Q6ZMK1
genes like me logo Genes that share domains with CYHR1: view

No data available for Gene Families for CYHR1 Gene

Function for CYHR1 Gene

Gene Ontology (GO) - Molecular Function for CYHR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with CYHR1: view

Phenotypes for CYHR1 Gene

GenomeRNAi human phenotypes for CYHR1:
genes like me logo Genes that share phenotypes with CYHR1: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CYHR1 Gene

Localization for CYHR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYHR1 Gene

Cytoplasm. Cytoplasm, perinuclear region. Note=Shows a prominent perinuclear and cytoplasmic localization. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CYHR1 Gene COMPARTMENTS Subcellular localization image for CYHR1 gene
Compartment Confidence
extracellular 2
nucleus 2
cytosol 1
endoplasmic reticulum 1
lysosome 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CYHR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005635 nuclear envelope IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm --
GO:0048471 perinuclear region of cytoplasm IEA --
genes like me logo Genes that share ontologies with CYHR1: view

Pathways for CYHR1 Gene

SuperPathways for CYHR1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CYHR1 Gene

None

No data available for Pathways by source for CYHR1 Gene

Transcripts for CYHR1 Gene

Unigene Clusters for CYHR1 Gene

Cysteine/histidine-rich 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CYHR1 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3a · 3b ^ 4a · 4b · 4c · 4d · 4e · 4f ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b
SP1: - - - - - -
SP2: - - - - - - - - - -
SP3: - -
SP4: - - - - - -
SP5: - -
SP6: -
SP7:
SP8: -
SP9:
SP10:
SP11: -

Relevant External Links for CYHR1 Gene

GeneLoc Exon Structure for
CYHR1
ECgene alternative splicing isoforms for
CYHR1

Expression for CYHR1 Gene

mRNA expression in normal human tissues for CYHR1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CYHR1 Gene

SOURCE GeneReport for Unigene cluster for CYHR1 Gene Hs.459379

genes like me logo Genes that share expressions with CYHR1: view

Orthologs for CYHR1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CYHR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CYHR1 36
  • 99.3 (n)
  • 99.4 (a)
CYHR1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CYHR1 36
  • 93.55 (n)
  • 97.81 (a)
CYHR1 37
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CYHR1 36
  • 91.44 (n)
  • 95.3 (a)
CYHR1 37
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cyhr1 36
  • 89.82 (n)
  • 96.14 (a)
Cyhr1 16
Cyhr1 37
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CYHR1 37
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CYHR1 37
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cyhr1 36
  • 85.97 (n)
  • 91.14 (a)
lizard
(Anolis carolinensis)
Reptilia CYHR1 37
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101735269 36
  • 82.63 (n)
  • 92.12 (a)
zebrafish
(Danio rerio)
Actinopterygii cyhr1 36
  • 78.61 (n)
  • 83.28 (a)
cyhr1 37
  • 68 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002264 36
  • 58.25 (n)
  • 50.51 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG32486 36
  • 58.59 (n)
  • 52.22 (a)
CG32486 37
  • 38 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8507 37
  • 44 (a)
OneToOne
Species with no ortholog for CYHR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CYHR1 Gene

ENSEMBL:
Gene Tree for CYHR1 (if available)
TreeFam:
Gene Tree for CYHR1 (if available)

Paralogs for CYHR1 Gene

No data available for Paralogs for CYHR1 Gene

Variants for CYHR1 Gene

Sequence variations from dbSNP and Humsavar for CYHR1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs731254 -- 144,456,284(-) GCATG(G/T)GACCA intron-variant
rs748193 -- 144,456,732(+) CATCA(C/T)GGGAA intron-variant
rs748194 -- 144,456,992(+) GGGGA(A/T)GACAT intron-variant
rs748195 -- 144,457,131(+) TGTGG(C/T)GACAG intron-variant
rs1046830 -- 144,463,867(-) CCAGA(A/G)AAGAG utr-variant-3-prime, intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CYHR1 Gene

Variant ID Type Subtype PubMed ID
nsv470249 CNV Loss 18288195
nsv515809 CNV Gain+Loss 19592680
nsv891807 CNV Loss 21882294
nsv428208 CNV Gain 18775914
nsv891817 CNV Loss 21882294
dgv7959n71 CNV Loss 21882294
nsv891841 CNV Loss 21882294
nsv891845 CNV Gain 21882294
nsv891846 CNV Loss 21882294
dgv2264e1 CNV Complex 17122850
nsv831489 CNV Loss 17160897
dgv7966n71 CNV Loss 21882294
dgv7967n71 CNV Loss 21882294
dgv7968n71 CNV Loss 21882294
dgv7969n71 CNV Loss 21882294
dgv7970n71 CNV Loss 21882294
dgv7971n71 CNV Loss 21882294
dgv7972n71 CNV Loss 21882294
dgv7973n71 CNV Loss 21882294
dgv907n27 CNV Loss 19166990
nsv891887 CNV Gain 21882294
dgv7975n71 CNV Loss 21882294
nsv891891 CNV Loss 21882294
dgv7976n71 CNV Loss 21882294
dgv7977n71 CNV Loss 21882294
dgv7978n71 CNV Loss 21882294
nsv891897 CNV Loss 21882294
esv1003467 CNV Deletion 20482838
esv29999 CNV Loss 17803354
dgv7979n71 CNV Loss 21882294
esv26548 CNV Gain 19812545
dgv7980n71 CNV Loss 21882294

Relevant External Links for CYHR1 Gene

HapMap Linkage Disequilibrium report
CYHR1

Disorders for CYHR1 Gene

No disorders were found for CYHR1 Gene.

No data available for UniProtKB/Swiss-Prot for CYHR1 Gene

Publications for CYHR1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. Characterization of cDNA clones in size-fractionated cDNA libraries from human brain. (PMID: 9455484) Seki N. … Ohara O. (DNA Res. 1997) 3 4
  3. Interaction of a novel cysteine and histidine-rich cytoplasmic protein with galectin-3 in a carbohydrate-independent manner. (PMID: 10745073) Menon R.P. … Hughes R.C. (FEBS Lett. 2000) 2 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo M.F. … Soares M.B. (Genome Res. 1996) 3

Products for CYHR1 Gene

Sources for CYHR1 Gene

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