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Aliases for CYHR1 Gene

Aliases for CYHR1 Gene

  • Cysteine And Histidine Rich 1 2 3 5
  • Cysteine/Histidine-Rich 1 2 3
  • Cysteine And Histidine-Rich Protein 1 3
  • Cysteine And Histidine Rich Protein 3
  • KIAA0496 4
  • CHRP 3

External Ids for CYHR1 Gene

Previous GeneCards Identifiers for CYHR1 Gene

  • GC08U990106
  • GC08M145646
  • GC08M145660
  • GC08M140788
  • GC08M145674

Summaries for CYHR1 Gene

GeneCards Summary for CYHR1 Gene

CYHR1 (Cysteine And Histidine Rich 1) is a Protein Coding gene.

Additional gene information for CYHR1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYHR1 Gene

Genomics for CYHR1 Gene

Regulatory Elements for CYHR1 Gene

Enhancers for CYHR1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08H143914 2.2 FANTOM5 Ensembl ENCODE dbSUPER 10.1 +528.6 528561 45.2 MLX FEZF1 DMAP1 YY1 ZNF143 SP3 MEF2D ZNF610 GLIS1 RCOR2 PLEC ZNF251 ZNF517 ZNF250 ZNF7 LOC105375803 EEF1D ZNF623 CPSF1 VPS28
GH08H143493 2.2 Ensembl ENCODE dbSUPER 10.1 +971.2 971234 2.6 RING1 MAZ GFI1B ZBTB8A ZIC2 ZFHX2 GLIS2 GLIS1 CREB1 FOXP2 ENSG00000254859 JRK ZNF696 ZNF623 CYHR1 CPSF1 VPS28 ZC3H3 GC08P143506 PIR44330
GH08H143514 1.8 FANTOM5 Ensembl ENCODE dbSUPER 11.3 +947.1 947098 7.4 PKNOX1 MLX ZFP64 FEZF1 GLIS2 ATF7 SP5 ZHX2 MXD4 TSHZ1 ENSG00000254859 GSDMD ENSG00000254574 ENSG00000253728 CPSF1 CYHR1 ZNF707 SHARPIN TOP1MT NAPRT
GH08H143731 1.7 FANTOM5 ENCODE dbSUPER 10.1 +728.4 728444 11.1 HDGF PKNOX1 ARID4B SIN3A ZBTB7B ZNF143 ZNF207 FOS SP3 SP5 ENSG00000254548 FAM83H-AS1 LRRC14 FAM83H LOC105375803 ZNF696 ZNF623 CYHR1 CPSF1 VPS28
GH08H144455 1.4 Ensembl ENCODE 11.7 +9.2 9245 1.6 HNRNPUL1 HDGF PKNOX1 FOXA2 ARNT ZFP64 SIN3A ZNF2 ZNF766 ZNF416 ZNF251 ZNF623 ZNF7 ZNF250 ZNF16 LRRC14 VPS28 CPSF1 ZNF517 ZNF34
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CYHR1 on UCSC Golden Path with GeneCards custom track

Promoters for CYHR1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000232255 -409 2201 PKNOX1 ATF1 ARID4B SIN3A DMAP1 ZBTB7B ETS1 ZNF121 GLIS2 ELK1

Transcription factor binding sites by QIAGEN in the CYHR1 gene promoter:

Genomic Locations for CYHR1 Gene

Genomic Locations for CYHR1 Gene
16,110 bases
Minus strand

Genomic View for CYHR1 Gene

Genes around CYHR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CYHR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CYHR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYHR1 Gene

Proteins for CYHR1 Gene

  • Protein details for CYHR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cysteine and histidine-rich protein 1
    Protein Accession:
    Secondary Accessions:
    • B3KSX0
    • D3DWM3
    • Q9BSF6
    • Q9BSU6

    Protein attributes for CYHR1 Gene

    362 amino acids
    Molecular mass:
    40703 Da
    Quaternary structure:
    • Interacts with LGALS3.
    • Sequence=BAD18724.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CYHR1 Gene


neXtProt entry for CYHR1 Gene

Post-translational modifications for CYHR1 Gene

  • Ubiquitination at isoforms=2, 4104, isoforms=2292, and posLast=349349
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CYHR1 Gene

Domains & Families for CYHR1 Gene

Gene Families for CYHR1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for CYHR1 Gene

Suggested Antigen Peptide Sequences for CYHR1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the CYHR1 family.
  • Belongs to the CYHR1 family.
genes like me logo Genes that share domains with CYHR1: view

Function for CYHR1 Gene

Phenotypes From GWAS Catalog for CYHR1 Gene

Gene Ontology (GO) - Molecular Function for CYHR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with CYHR1: view

Phenotypes for CYHR1 Gene

genes like me logo Genes that share phenotypes with CYHR1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CYHR1 Gene

Localization for CYHR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYHR1 Gene

Cytoplasm. Cytoplasm, perinuclear region. Note=Shows a prominent perinuclear and cytoplasmic localization. {ECO:0000250}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CYHR1 gene
Compartment Confidence
nucleus 5
extracellular 2
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
cytosol 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CYHR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0048471 perinuclear region of cytoplasm IEA --
genes like me logo Genes that share ontologies with CYHR1: view

Pathways & Interactions for CYHR1 Gene

SuperPathways for CYHR1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CYHR1 Gene


No data available for Pathways by source and SIGNOR curated interactions for CYHR1 Gene

Drugs & Compounds for CYHR1 Gene

No Compound Related Data Available

Transcripts for CYHR1 Gene

Unigene Clusters for CYHR1 Gene

Cysteine/histidine-rich 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CYHR1 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3a · 3b ^ 4a · 4b · 4c · 4d · 4e · 4f ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b
SP1: - - - - - -
SP2: - - - - - - - - - -
SP3: - -
SP4: - - - - - -
SP5: - -
SP6: -
SP8: -
SP11: -

Relevant External Links for CYHR1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CYHR1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CYHR1 Gene

Protein differential expression in normal tissues from HIPED for CYHR1 Gene

This gene is overexpressed in Testis (13.6), Fetal Brain (9.7), Retina (8.6), Fetal ovary (6.4), and Islet of Langerhans (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CYHR1 Gene

Protein tissue co-expression partners for CYHR1 Gene

NURSA nuclear receptor signaling pathways regulating expression of CYHR1 Gene:


SOURCE GeneReport for Unigene cluster for CYHR1 Gene:


Evidence on tissue expression from TISSUES for CYHR1 Gene

  • Nervous system(4.7)
  • Lung(4.3)
  • Spleen(4.2)
genes like me logo Genes that share expression patterns with CYHR1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CYHR1 Gene

Orthologs for CYHR1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CYHR1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CYHR1 33 34
  • 99.3 (n)
(Bos Taurus)
Mammalia CYHR1 33 34
  • 93.55 (n)
(Canis familiaris)
Mammalia CYHR1 33 34
  • 91.44 (n)
(Monodelphis domestica)
Mammalia CYHR1 34
  • 91 (a)
(Ornithorhynchus anatinus)
Mammalia CYHR1 34
  • 91 (a)
(Mus musculus)
Mammalia Cyhr1 33 16 34
  • 89.82 (n)
(Rattus norvegicus)
Mammalia Cyhr1 33
  • 85.97 (n)
(Anolis carolinensis)
Reptilia CYHR1 34
  • 60 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101735269 33
  • 82.63 (n)
(Danio rerio)
Actinopterygii cyhr1 33 34
  • 78.61 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG32486 33 34
  • 58.59 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002264 33
  • 58.25 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8507 34
  • 44 (a)
Species where no ortholog for CYHR1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CYHR1 Gene

Gene Tree for CYHR1 (if available)
Gene Tree for CYHR1 (if available)

Paralogs for CYHR1 Gene

No data available for Paralogs for CYHR1 Gene

Variants for CYHR1 Gene

Sequence variations from dbSNP and Humsavar for CYHR1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1000026052 -- 144,459,645(+) TGGAT(A/G)ACAAG intron-variant
rs1000209806 -- 144,462,357(+) CAGTT(C/T)CCCGC intron-variant, reference, missense
rs1000336116 -- 144,462,617(+) CCGCG(A/G)CCGGG intron-variant, reference, missense
rs1000379339 -- 144,455,239(+) GAACC(C/T)GGGAG intron-variant, utr-variant-5-prime
rs1000393001 -- 144,466,237(+) TCCAG(A/G)TGCGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CYHR1 Gene

Variant ID Type Subtype PubMed ID
nsv831489 CNV loss 17160897
nsv612947 CNV loss 21841781
nsv612946 CNV loss 21841781
nsv612940 CNV loss 21841781
nsv612936 CNV loss 21841781
nsv612935 CNV loss 21841781
nsv515809 CNV gain+loss 19592680
nsv470249 CNV loss 18288195
nsv428208 CNV gain 18775914
nsv1144242 CNV deletion 24896259
nsv1077079 CNV deletion 25765185
nsv1077078 CNV deletion 25765185
esv29999 CNV loss 17803354
esv2759652 CNV gain+loss 17122850
esv26548 CNV gain 19812545
esv1003467 CNV deletion 20482838
dgv907n27 CNV loss 19166990
dgv3934n106 CNV deletion 24896259
dgv12440n54 CNV loss 21841781
dgv12439n54 CNV loss 21841781
dgv12438n54 CNV loss 21841781
dgv12434n54 CNV loss 21841781

Variation tolerance for CYHR1 Gene

Gene Damage Index Score: 0.38; 8.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CYHR1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CYHR1 Gene

Disorders for CYHR1 Gene

Relevant External Links for CYHR1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CYHR1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CYHR1 Gene

Publications for CYHR1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  2. Interaction of a novel cysteine and histidine-rich cytoplasmic protein with galectin-3 in a carbohydrate-independent manner. (PMID: 10745073) Menon RP … Hughes RC (FEBS letters 2000) 2 3 60
  3. Characterization of cDNA clones in size-fractionated cDNA libraries from human brain. (PMID: 9455484) Seki N … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1997) 3 4 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. (PMID: 27173435) Boldt K … UK10K Rare Diseases Group (Nature communications 2016) 3 60

Products for CYHR1 Gene

Sources for CYHR1 Gene

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