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Aliases for CYHR1 Gene

Aliases for CYHR1 Gene

  • Cysteine And Histidine Rich 1 2 3 5
  • Cysteine/Histidine-Rich 1 2 3
  • Cysteine And Histidine-Rich Protein 1 3
  • Cysteine And Histidine Rich Protein 3
  • KIAA0496 4
  • CHRP 3

External Ids for CYHR1 Gene

Previous GeneCards Identifiers for CYHR1 Gene

  • GC08U990106
  • GC08M145646
  • GC08M145660
  • GC08M140788
  • GC08M145674

Summaries for CYHR1 Gene

GeneCards Summary for CYHR1 Gene

CYHR1 (Cysteine And Histidine Rich 1) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYHR1 Gene

Genomics for CYHR1 Gene

Regulatory Elements for CYHR1 Gene

Enhancers for CYHR1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08F143493 2.2 Ensembl ENCODE 10.1 +971.2 971234 2.6 HDAC1 CBX3 ARNT ARID4B SIN3A DMAP1 ZNF2 RAD21 GLIS2 ELK1 ENSG00000254859 JRK ZNF696 ZNF623 CYHR1 VPS28 ZC3H3 GC08P143506 PIR44330
GH08F143914 1.9 FANTOM5 Ensembl ENCODE 10.1 +528.6 528561 45.2 MLX CREB3L1 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF263 SP3 ZNF251 ZNF250 ZNF517 LRRC14 PLEC LOC105375803 ZNF696 ZNF623 VPS28 COMMD5
GH08F143731 1.4 FANTOM5 ENCODE 10.1 +728.4 728444 11.1 HDGF PKNOX1 CREB3L1 ARID4B SIN3A ZNF143 FOS SP3 SP5 ZHX2 LRRC14 ZNF696 LOC105375803 ENSG00000254548 VPS28 FAM83H-AS1 FAM83H ARHGAP39 ADCK5 ZNF623
GH08F144506 1.1 ENCODE 10.3 -43.3 -43279 4.0 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 CBX5 ZNF207 ZNF251 ZNF250 PPP1R16A LOC105375803 LRRC14 ENSG00000254533 ZNF517 TMED10P1 ENSG00000255164 ENSG00000255085
GH08F144407 1.1 ENCODE 10.3 +55.5 55522 4.8 HDGF CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZNF143 ZNF207 KLF13 ZNF251 CPSF1 ZNF517 ZNF250 LOC105375803 ENSG00000255456 ENSG00000254574 LRRC14 C8orf82 TMED10P1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CYHR1 on UCSC Golden Path with GeneCards custom track

Promoters for CYHR1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001404434 -409 2601 ATF1 PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF48 ZNF121 GLIS2 ZNF143

Transcription factor binding sites by QIAGEN in the CYHR1 gene promoter:

Genomic Location for CYHR1 Gene

144,449,582 bp from pter
144,465,691 bp from pter
16,110 bases
Minus strand

Genomic View for CYHR1 Gene

Genes around CYHR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CYHR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CYHR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYHR1 Gene

Proteins for CYHR1 Gene

  • Protein details for CYHR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cysteine and histidine-rich protein 1
    Protein Accession:
    Secondary Accessions:
    • B3KSX0
    • D3DWM3
    • Q9BSF6
    • Q9BSU6

    Protein attributes for CYHR1 Gene

    362 amino acids
    Molecular mass:
    40703 Da
    Quaternary structure:
    • Interacts with LGALS3.
    • Sequence=BAD18724.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CYHR1 Gene


neXtProt entry for CYHR1 Gene

Post-translational modifications for CYHR1 Gene

  • Ubiquitination at Lys 104, Lys 292, and Lys 349
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CYHR1 Gene

Domains & Families for CYHR1 Gene

Protein Domains for CYHR1 Gene

Suggested Antigen Peptide Sequences for CYHR1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the CYHR1 family.
  • Contains 1 RING-type zinc finger.
  • Belongs to the CYHR1 family.
  • Contains 1 RING-type zinc finger.
  • Contains 1 TRAF-type zinc finger.
genes like me logo Genes that share domains with CYHR1: view

No data available for Gene Families for CYHR1 Gene

Function for CYHR1 Gene

Gene Ontology (GO) - Molecular Function for CYHR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity IEA --
GO:0004842 ubiquitin-protein transferase activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0008201 heparin binding IEA --
GO:0008237 metallopeptidase activity IEA --
genes like me logo Genes that share ontologies with CYHR1: view

Phenotypes for CYHR1 Gene

genes like me logo Genes that share phenotypes with CYHR1: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CYHR1 Gene

Localization for CYHR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYHR1 Gene

Cytoplasm. Cytoplasm, perinuclear region. Note=Shows a prominent perinuclear and cytoplasmic localization. {ECO:0000250}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CYHR1 gene
Compartment Confidence
nucleus 5
extracellular 2
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for CYHR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IDA --
GO:0005578 proteinaceous extracellular matrix IDA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with CYHR1: view

Pathways & Interactions for CYHR1 Gene

SuperPathways for CYHR1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CYHR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with CYHR1: view

No data available for Pathways by source and SIGNOR curated interactions for CYHR1 Gene

Transcripts for CYHR1 Gene

Unigene Clusters for CYHR1 Gene

Cysteine/histidine-rich 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CYHR1 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3a · 3b ^ 4a · 4b · 4c · 4d · 4e · 4f ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b
SP1: - - - - - -
SP2: - - - - - - - - - -
SP3: - -
SP4: - - - - - -
SP5: - -
SP6: -
SP8: -
SP11: -

Relevant External Links for CYHR1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CYHR1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CYHR1 Gene

Protein differential expression in normal tissues from HIPED for CYHR1 Gene

This gene is overexpressed in Testis (13.6), Fetal Brain (9.7), Retina (8.6), Fetal ovary (6.4), and Islet of Langerhans (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CYHR1 Gene

Protein tissue co-expression partners for CYHR1 Gene

NURSA nuclear receptor signaling pathways regulating expression of CYHR1 Gene:


SOURCE GeneReport for Unigene cluster for CYHR1 Gene:

genes like me logo Genes that share expression patterns with CYHR1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CYHR1 Gene

Orthologs for CYHR1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CYHR1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CYHR1 34 35
  • 99.3 (n)
(Bos Taurus)
Mammalia CYHR1 34 35
  • 93.55 (n)
(Canis familiaris)
Mammalia CYHR1 34 35
  • 91.44 (n)
(Monodelphis domestica)
Mammalia CYHR1 35
  • 91 (a)
(Ornithorhynchus anatinus)
Mammalia CYHR1 35
  • 91 (a)
(Mus musculus)
Mammalia Cyhr1 34 16 35
  • 89.82 (n)
(Rattus norvegicus)
Mammalia Cyhr1 34
  • 85.97 (n)
(Anolis carolinensis)
Reptilia CYHR1 35
  • 60 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101735269 34
  • 82.63 (n)
(Danio rerio)
Actinopterygii cyhr1 34 35
  • 78.61 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG32486 34 35
  • 58.59 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002264 34
  • 58.25 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8507 35
  • 44 (a)
Species where no ortholog for CYHR1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CYHR1 Gene

Gene Tree for CYHR1 (if available)
Gene Tree for CYHR1 (if available)

Paralogs for CYHR1 Gene

No data available for Paralogs for CYHR1 Gene

Variants for CYHR1 Gene

Sequence variations from dbSNP and Humsavar for CYHR1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs10096642 -- 144,461,990(+) GAAAA(A/G)AGAAG intron-variant
rs10108150 -- 144,462,092(+) TGAGA(A/G)AAAGA intron-variant
rs10113848 -- 144,454,017(+) CAGAG(A/G)CCTCC intron-variant, utr-variant-5-prime
rs1046830 -- 144,463,867(-) CCAGA(A/G)AAGAG intron-variant, upstream-variant-2KB, utr-variant-3-prime
rs1058858 -- 144,450,126(-) GGTGC(A/C)CCAGG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CYHR1 Gene

Variant ID Type Subtype PubMed ID
nsv831489 CNV loss 17160897
nsv612947 CNV loss 21841781
nsv612946 CNV loss 21841781
nsv612940 CNV loss 21841781
nsv612936 CNV loss 21841781
nsv612935 CNV loss 21841781
nsv515809 CNV gain+loss 19592680
nsv470249 CNV loss 18288195
nsv428208 CNV gain 18775914
nsv1144242 CNV deletion 24896259
nsv1077079 CNV deletion 25765185
nsv1077078 CNV deletion 25765185
esv29999 CNV loss 17803354
esv2759652 CNV gain+loss 17122850
esv26548 CNV gain 19812545
esv1003467 CNV deletion 20482838
dgv907n27 CNV loss 19166990
dgv3934n106 CNV deletion 24896259
dgv12440n54 CNV loss 21841781
dgv12439n54 CNV loss 21841781
dgv12438n54 CNV loss 21841781
dgv12434n54 CNV loss 21841781

Variation tolerance for CYHR1 Gene

Gene Damage Index Score: 0.38; 8.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CYHR1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CYHR1 Gene

Disorders for CYHR1 Gene

Relevant External Links for CYHR1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CYHR1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CYHR1 Gene

Publications for CYHR1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. Interaction of a novel cysteine and histidine-rich cytoplasmic protein with galectin-3 in a carbohydrate-independent manner. (PMID: 10745073) Menon R.P. … Hughes R.C. (FEBS Lett. 2000) 2 3 64
  3. Characterization of cDNA clones in size-fractionated cDNA libraries from human brain. (PMID: 9455484) Seki N. … Ohara O. (DNA Res. 1997) 3 4 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64

Products for CYHR1 Gene

Sources for CYHR1 Gene

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