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CYHR1 Gene

protein-coding   GIFtS: 46
GCID: GC08M145674

Cysteine/Histidine-Rich 1

(Previous name: cysteine and histidine rich 1)
  Search for CYHR1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cysteine/Histidine-Rich 11 2
Cysteine And Histidine Rich 11 2
CHRP2
Cysteine And Histidine Rich Protein2
Cysteine And Histidine-Rich Protein 12
KIAA04963

External Ids:    HGNC: 178061   Entrez Gene: 506262   Ensembl: ENSG000001879547   UniProtKB: Q6ZMK13   

Export aliases for CYHR1 gene to outside databases

Previous GC identifers: GC08U990106 GC08M145646 GC08M145660 GC08M140788


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CYHR1 Gene:
CYHR1 (cysteine/histidine-rich 1) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000008.11  NT_008046.17  NC_018919.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CYHR1 gene promoter:
         Sp1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCYHR1 promoter sequence
   Search Chromatin IP Primers for CYHR1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CYHR1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q24.3   Ensembl cytogenetic band:  8q24.3   HGNC cytogenetic band: 8q24

CYHR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CYHR1 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M145674:  view genomic region     (about GC identifiers)

Start:
145,674,965 bp from pter      End:
145,691,060 bp from pter
Size:
16,096 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CYHR1_HUMAN, Q6ZMK1 (See protein sequence)
Recommended Name: Cysteine and histidine-rich protein 1  
Size: 362 amino acids; 40703 Da
Subunit: Interacts with LGALS3 (By similarity)
Sequence caution: Sequence=BAD18724.1; Type=Erroneous initiation;
Secondary accessions: B3KSX0 D3DWM3 Q9BSF6 Q9BSU6
Alternative splicing: 4 isoforms:  Q6ZMK1-1   Q6ZMK1-2   Q6ZMK1-3   Q6ZMK1-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CYHR1: NX_Q6ZMK1

Explore proteomics data for CYHR1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys104, Lys292, Lys349
  • Modification sites at PhosphoSitePlus

  • See CYHR1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001123360.1  NP_116076.1  NP_612505.1  

    ENSEMBL proteins: 
     ENSP00000387426   ENSP00000433769   ENSP00000434470   ENSP00000385962   ENSP00000414647  
     ENSP00000304826   ENSP00000432902   ENSP00000434642  

    CYHR1 Human Recombinant Protein Products:

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    Cloud-Clone Corp. CLIAs for CYHR1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR008974 TRAF-like
     IPR013083 Znf_RING/FYVE/PHD
     IPR001293 Znf_TRAF

    Graphical View of Domain Structure for InterPro Entry Q6ZMK1

    ProtoNet protein and cluster: Q6ZMK1

    UniProtKB/Swiss-Prot: CYHR1_HUMAN, Q6ZMK1
    Similarity: Belongs to the CYHR1 family
    Similarity: Contains 1 RING-type zinc finger
    Similarity: Contains 1 TRAF-type zinc finger


    CYHR1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
         
    CYHR1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CYHR1:
     Decreased viability with pacli 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CYHR1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CYHR1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CYHR1

    miRNA
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    3 qRT-PCR Assays for microRNAs that regulate CYHR1:
    hsa-miR-3166 hsa-miR-4279 hsa-miR-4273
    SwitchGear 3'UTR luciferase reporter plasmidCYHR1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CYHR1
    Predesigned siRNA for gene silencing in human, mouse, rat CYHR1

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for CYHR1

    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 3): CYHR1 (NM_138496)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CYHR1

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYHR1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CYHR1_HUMAN, Q6ZMK1: Cytoplasm (By similarity). Cytoplasm, perinuclear region (By similarity). Note=Shows a
    prominent perinuclear and cytoplasmic localization (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular2
    nucleus2
    cytosol1
    endoplasmic reticulum1
    lysosome1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005635nuclear envelope IEA--
    GO:0005737cytoplasm ----
    GO:0048471perinuclear region of cytoplasm IEA--

    CYHR1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CYHR1
    Interactions:

        Search GeneGlobe Interaction Network for CYHR1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    Selected Interacting proteins for CYHR1 (Q6ZMK13 ENSP000003874264) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ECHS1P300843, ENSP000003575354I2D: score=1 STRING: ENSP00000357535
    LGALS3P179313, ENSP000002543014I2D: score=1 STRING: ENSP00000254301
    UBE2KP610863, ENSP000002614274I2D: score=5 STRING: ENSP00000261427
    COPS4Q9BT783I2D: score=5 
    SCP2P223073I2D: score=5 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CYHR1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CYHR1 gene (3 alternative transcripts): 
    NM_001129888.1  NM_032687.3  NM_138496.1  

    Unigene Cluster for CYHR1:

    Cysteine/histidine-rich 1
    Hs.459379  [show with all ESTs]
    Unigene Representative Sequence: AB007965
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000528663 ENST00000438911(uc003zcv.2) ENST00000530374 ENST00000526887
    ENST00000533173 ENST00000528558 ENST00000403000(uc003zcx.2) ENST00000424149(uc003zcy.2)
    ENST00000306145(uc003zcw.2) ENST00000533764 ENST00000530637 ENST00000524623

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CYHR1 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate CYHR1:
    hsa-miR-3166 hsa-miR-4279 hsa-miR-4273
    SwitchGear 3'UTR luciferase reporter plasmidCYHR1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CYHR1
    Predesigned siRNA for gene silencing in human, mouse, rat CYHR1
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    GenScript: all cDNA clones in your preferred vector (see all 3): CYHR1 (NM_138496)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CYHR1
    Primer
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    OriGene qPCR primer pairs and template standards for CYHR1
    OriGene qSTAR qPCR primer pairs in human, mouse for CYHR1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CYHR1
      QuantiTect SYBR Green Assays in human, mouse, rat CYHR1
      QuantiFast Probe-based Assays in human, mouse, rat CYHR1

    Additional mRNA sequence: 

    AB007965.1 AK094514.1 AK160381.1 BC004544.2 BC005073.1 BC056412.1 BC065484.1 

    14 DOTS entries:

    DT.97862092  DT.313040  DT.75122970  DT.40194945  DT.443215  DT.92422079  DT.92422088  DT.95271126 
    DT.97862091  DT.100036735  DT.91661729  DT.100754297  DT.86854373  DT.92422081 

    Selected AceView cDNA sequences (see all 254):

    AI982764 BM797552 BM832785 BM671891 BQ683590 AW169601 AI479794 BM662154 
    BM754169 BM313717 AI499360 BM695235 BM748073 AI318085 BM042303 AI880303 
    AI362779 CK819067 BQ956567 AI935167 BU630101 BM908508 BC056412 BM974393 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CYHR1 (see all 11)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3a · 3b ^ 4a · 4b · 4c · 4d · 4e · 4f ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b
    SP1:                                                                                -     -     -     -     -                       -               
    SP2:                                      -                 -     -     -     -     -     -     -     -     -                                       
    SP3:                                                                                                        -                       -               
    SP4:        -     -     -     -     -     -                                                                                                         
    SP5:                                -     -                                                                                                         


    ECgene alternative splicing isoforms for CYHR1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CYHR1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGCTGGCAG
    CYHR1 Expression
    About this image

    CYHR1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CYHR1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.459379
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYHR1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CYHR1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cyhr11 , 5 cysteine and histidine rich 11, 5 89.82(n)1
    96.14(a)1
      15 (36.20 cM)5
    541511  NM_019396.31  NP_062269.11 
     766433955 
    lizard
    (Anolis carolinensis)
    Reptilia CYHR16
    cysteine/histidine-rich 1
    60(a)
    1 ↔ 1
    GL343892.1(2190-20845)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1017352691 cysteine and histidine-rich protein 1-A-like 82.63(n)
    92.12(a)
      101735269  XM_004920488.1  XP_004920545.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cyhr11 cysteine/histidine-rich 1 78.61(n)
    83.28(a)
      767773  NM_001076740.1  NP_001070208.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG324861 CG32486 58.59(n)
    52.22(a)
      38367  NM_139508.3  NP_647765.1 


    ENSEMBL Gene Tree for CYHR1 (if available)
    TreeFam Gene Tree for CYHR1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CYHR1 (see all 400)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2016400671,2
    C--140805957(+) CTGGGC/TCCACC 1 -- us2k10--------
    rs2009688531,2
    --140805959(+) GGGCCC/TACCCT 1 -- us2k10--------
    rs1421248801,2
    C--140805960(+) GGCCCA/GCCCTA 1 -- us2k10--------
    rs1460573511,2
    C--140805962(+) CCCACC/TCTACT 1 -- us2k11Minor allele frequency- T:0.00EU 1299
    rs2000971751,2
    C--140805966(+) CCCTAC/TTCCAG 1 -- us2k10--------
    rs2001989631,2
    --140806146(+) GATTGC/TCGGCT 1 -- us2k10--------
    rs1997062661,2
    C--140806147(+) ATTGCC/TGGCTG 1 -- us2k10--------
    rs1914432381,2
    --145674873(+) CCAGGC/TGCCCA 1 -- ds50010--------
    rs1158081511,2
    F--145674911(+) CTGGGG/AACGCT 1 -- ds50011Minor allele frequency- A:0.03WA 118
    rs1479544831,2
    --145675002(+) TTAATC/TTTTTT 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for CYHR1 (145674965 - 145691060 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for CYHR1 (see all 32):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1003467CNV Deletion20482838
    dgv907n27CNV Loss19166990
    dgv7966n71CNV Loss21882294
    dgv7977n71CNV Loss21882294
    dgv7976n71CNV Loss21882294
    nsv891841CNV Loss21882294
    dgv7978n71CNV Loss21882294
    dgv7980n71CNV Loss21882294
    nsv891846CNV Loss21882294
    nsv891817CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CYHR1
    DNA2.0 Custom Variant and Variant Library Synthesis for CYHR1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CYHR1 gene, integrated from 10 sources (see all 13):
    (articles sorted by number of sources associating them with CYHR1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    2. Interaction of a novel cysteine and histidine-rich cytoplasmic protein with galectin-3 in a carbohydrate-independent manner. (PubMed id 10745073)1, 3 Menon R.P....Hughes R.C. (FEBS Lett. 2000)
    3. Characterization of cDNA clones in size-fractionated cDNA libraries from human brain. (PubMed id 9455484)1, 2 Seki N.... Ohara O. (DNA Res. 1997)
    4. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    5. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)
    6. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    7. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    8. Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymes. (PubMed id 22118674)1 Altun M....Kessler B.M. (amp 2011)
    9. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    10. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 50626 HGNC: 17806 AceView: CYHR1 Ensembl:ENSG00000187954 euGenes: HUgn50626
    ECgene: CYHR1 H-InvDB: CYHR1

    (According to HUGE)
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    HUGE: KIAA0496

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CYHR1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CYHR1 gene:
    Search GeneIP for patents involving CYHR1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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