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Aliases for CYHR1 Gene

Aliases for CYHR1 Gene

  • Cysteine/Histidine-Rich 1 2 3 5
  • Cysteine And Histidine Rich 1 2 3
  • Cysteine And Histidine Rich Protein 3
  • KIAA0496 4
  • CHRP 3

External Ids for CYHR1 Gene

Previous GeneCards Identifiers for CYHR1 Gene

  • GC08U990106
  • GC08M145646
  • GC08M145660
  • GC08M140788
  • GC08M145674

Summaries for CYHR1 Gene

GeneCards Summary for CYHR1 Gene

CYHR1 (Cysteine/Histidine-Rich 1) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYHR1 Gene

Genomics for CYHR1 Gene

Regulatory Elements for CYHR1 Gene

Enhancers for CYHR1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CYHR1 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the CYHR1 gene promoter:

Genomic Location for CYHR1 Gene

144,449,582 bp from pter
144,465,691 bp from pter
16,110 bases
Minus strand

Genomic View for CYHR1 Gene

Genes around CYHR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CYHR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CYHR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYHR1 Gene

Proteins for CYHR1 Gene

  • Protein details for CYHR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cysteine and histidine-rich protein 1
    Protein Accession:
    Secondary Accessions:
    • B3KSX0
    • D3DWM3
    • Q9BSF6
    • Q9BSU6

    Protein attributes for CYHR1 Gene

    362 amino acids
    Molecular mass:
    40703 Da
    Quaternary structure:
    • Interacts with LGALS3.
    • Sequence=BAD18724.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CYHR1 Gene


neXtProt entry for CYHR1 Gene

Proteomics data for CYHR1 Gene at MOPED

Post-translational modifications for CYHR1 Gene

  • Ubiquitination at Lys 104, Lys 292, and Lys 349
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CYHR1 Gene

Domains & Families for CYHR1 Gene

Protein Domains for CYHR1 Gene

Suggested Antigen Peptide Sequences for CYHR1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the CYHR1 family.
  • Contains 1 RING-type zinc finger.
  • Belongs to the CYHR1 family.
  • Contains 1 RING-type zinc finger.
  • Contains 1 TRAF-type zinc finger.
genes like me logo Genes that share domains with CYHR1: view

No data available for Gene Families for CYHR1 Gene

Function for CYHR1 Gene

Phenotypes for CYHR1 Gene

genes like me logo Genes that share phenotypes with CYHR1: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CYHR1 Gene

Localization for CYHR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYHR1 Gene

Cytoplasm. Cytoplasm, perinuclear region. Note=Shows a prominent perinuclear and cytoplasmic localization. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for CYHR1 Gene COMPARTMENTS Subcellular localization image for CYHR1 gene
Compartment Confidence
nucleus 5
extracellular 2
cytosol 1
endoplasmic reticulum 1
lysosome 1
mitochondrion 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for CYHR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0048471 perinuclear region of cytoplasm IEA --
genes like me logo Genes that share ontologies with CYHR1: view

Pathways & Interactions for CYHR1 Gene

SuperPathways for CYHR1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CYHR1 Gene


No data available for Pathways by source and SIGNOR curated interactions for CYHR1 Gene

Drugs & Compounds for CYHR1 Gene

No Compound Related Data Available

Transcripts for CYHR1 Gene

Unigene Clusters for CYHR1 Gene

Cysteine/histidine-rich 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CYHR1 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3a · 3b ^ 4a · 4b · 4c · 4d · 4e · 4f ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b
SP1: - - - - - -
SP2: - - - - - - - - - -
SP3: - -
SP4: - - - - - -
SP5: - -
SP6: -
SP8: -
SP11: -

Relevant External Links for CYHR1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CYHR1 Gene

mRNA expression in normal human tissues for CYHR1 Gene

Protein differential expression in normal tissues from HIPED for CYHR1 Gene

This gene is overexpressed in Testis (13.6), Fetal Brain (9.7), Retina (8.6), Fetal ovary (6.4), and Islet of Langerhans (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CYHR1 Gene

SOURCE GeneReport for Unigene cluster for CYHR1 Gene Hs.459379

genes like me logo Genes that share expression patterns with CYHR1: view

Protein tissue co-expression partners for CYHR1 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CYHR1 Gene

Orthologs for CYHR1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CYHR1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CYHR1 35
  • 93.55 (n)
  • 97.81 (a)
CYHR1 36
  • 95 (a)
(Canis familiaris)
Mammalia CYHR1 35
  • 91.44 (n)
  • 95.3 (a)
CYHR1 36
  • 95 (a)
(Mus musculus)
Mammalia Cyhr1 35
  • 89.82 (n)
  • 96.14 (a)
Cyhr1 16
Cyhr1 36
  • 96 (a)
(Pan troglodytes)
Mammalia CYHR1 35
  • 99.3 (n)
  • 99.4 (a)
CYHR1 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Cyhr1 35
  • 85.97 (n)
  • 91.14 (a)
(Monodelphis domestica)
Mammalia CYHR1 36
  • 91 (a)
(Ornithorhynchus anatinus)
Mammalia CYHR1 36
  • 91 (a)
(Anolis carolinensis)
Reptilia CYHR1 36
  • 60 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101735269 35
  • 82.63 (n)
  • 92.12 (a)
(Danio rerio)
Actinopterygii cyhr1 35
  • 78.61 (n)
  • 83.28 (a)
cyhr1 36
  • 68 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002264 35
  • 58.25 (n)
  • 50.51 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG32486 35
  • 58.59 (n)
  • 52.22 (a)
CG32486 36
  • 38 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8507 36
  • 44 (a)
Species with no ortholog for CYHR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CYHR1 Gene

Gene Tree for CYHR1 (if available)
Gene Tree for CYHR1 (if available)

Paralogs for CYHR1 Gene

No data available for Paralogs for CYHR1 Gene

Variants for CYHR1 Gene

Sequence variations from dbSNP and Humsavar for CYHR1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs2245052 -- 144,452,086(+) CAGGG(A/G)TGGTG intron-variant
rs2256094 -- 144,452,590(+) TACAT(C/G/T)ACTCA intron-variant
rs2620654 -- 144,449,781(+) CAGAG(C/T)GTAGG downstream-variant-500B, utr-variant-3-prime
rs2620655 -- 144,450,224(+) CGTCG(C/T)GCACG utr-variant-3-prime
rs2620656 -- 144,453,697(+) GGCCT(C/T)ATCAG intron-variant, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for CYHR1 Gene

Variant ID Type Subtype PubMed ID
nsv470249 CNV Loss 18288195
nsv515809 CNV Gain+Loss 19592680
nsv891807 CNV Loss 21882294
nsv428208 CNV Gain 18775914
nsv891817 CNV Loss 21882294
dgv7959n71 CNV Loss 21882294
nsv891841 CNV Loss 21882294
nsv891845 CNV Gain 21882294
nsv891846 CNV Loss 21882294
dgv2264e1 CNV Complex 17122850
nsv831489 CNV Loss 17160897
dgv7966n71 CNV Loss 21882294
dgv7967n71 CNV Loss 21882294
dgv7968n71 CNV Loss 21882294
dgv7969n71 CNV Loss 21882294
dgv7970n71 CNV Loss 21882294
dgv7971n71 CNV Loss 21882294
dgv7972n71 CNV Loss 21882294
dgv7973n71 CNV Loss 21882294
dgv907n27 CNV Loss 19166990
nsv891887 CNV Gain 21882294
dgv7975n71 CNV Loss 21882294
nsv891891 CNV Loss 21882294
dgv7976n71 CNV Loss 21882294
dgv7977n71 CNV Loss 21882294
dgv7978n71 CNV Loss 21882294
nsv891897 CNV Loss 21882294
esv1003467 CNV Deletion 20482838
esv29999 CNV Loss 17803354
dgv7979n71 CNV Loss 21882294
esv26548 CNV Gain 19812545
dgv7980n71 CNV Loss 21882294

Variation tolerance for CYHR1 Gene

Gene Damage Index Score: 0.38; 8.36% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CYHR1 Gene

Disorders for CYHR1 Gene

Relevant External Links for CYHR1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CYHR1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CYHR1 Gene

Publications for CYHR1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 67
  2. Interaction of a novel cysteine and histidine-rich cytoplasmic protein with galectin-3 in a carbohydrate-independent manner. (PMID: 10745073) Menon R.P. … Hughes R.C. (FEBS Lett. 2000) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. Common genetic variants associated with cognitive performance identified using the proxy-phenotype method. (PMID: 25201988) Rietveld C.A. … Koellinger P.D. (Proc. Natl. Acad. Sci. U.S.A. 2014) 3

Products for CYHR1 Gene

Sources for CYHR1 Gene