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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CYGB Gene

protein-coding   GIFtS: 53
GCID: GC17M074523

Cytoglobin

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
cytoglobin1 2     HGB2 5
Stellate Cell Activation-Associated Protein1 2 3     HGb3
STAP2 3 5     Histoglobin3
histoglobin1 2     

External Ids:    HGNC: 165051   Entrez Gene: 1147572   Ensembl: ENSG000001615447   OMIM: 6087595   UniProtKB: Q8WWM93   

Export aliases for CYGB gene to outside databases

Previous GC identifers: GC17M074357 GC17M077515 GC17M074987 GC17M075120 GC17M072035 GC17M069951


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CYGB Gene:
This gene encodes a globin protein found in vertebrate cells. The encoded protein is described as a hexacoordinate
hemoglobin which binds ligand differently from the pentacoordinate hemoglobins involved in oxygen transport, and
may be involved in protection during oxidative stress. This gene is located on chromosome 17 in the same region
as a retinal gene which is mutated in progressive rod-cone degeneration, but in the opposite orientation.
(provided by RefSeq, Jan 2012)

GeneCards Summary for CYGB Gene: 
CYGB (cytoglobin) is a protein-coding gene. Diseases associated with CYGB include hereditary neuralgic amyotrophy, and nutrition disease. GO annotations related to this gene include iron ion binding and oxygen binding. An important paralog of this gene is MB.

UniProtKB/Swiss-Prot: CYGB_HUMAN, Q8WWM9
Function: May have a protective function during conditions of oxidative stress. May be involved in intracellular
oxygen storage or transfer

Gene Wiki entry for CYGB (Cytoglobin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010783.15  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CYGB gene promoter:
         GATA-3   Sp1   RelA   XBP-1   HNF-3beta   Egr-2   ZIC2/Zic2   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCYGB promoter sequence
   Search SABiosciences Chromatin IP Primers for CYGB

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CYGB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25   Ensembl cytogenetic band:  17q25.1   HGNC cytogenetic band: 17q25

CYGB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CYGB gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M074523:  view genomic region     (about GC identifiers)

Start:
74,523,438 bp from pter      End:
74,547,257 bp from pter
Size:
23,820 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CYGB_HUMAN, Q8WWM9 (See protein sequence)
Recommended Name: Cytoglobin  
Size: 190 amino acids; 21405 Da
Subunit: Homodimer; disulfide-linked
Subcellular location: Cytoplasm (By similarity)
6/9 PDB 3D structures from and Proteopedia for CYGB (see all 9):
1UMO (3D)        1URV (3D)        1URY (3D)        1UT0 (3D)        1UX9 (3D)        1V5H (3D)    
Secondary accessions: Q541Y7 Q8N2X5

Explore the universe of human proteins at neXtProt for CYGB: NX_Q8WWM9

Explore proteomics data for CYGB at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8WWM9

  • CYGB Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CYGB Protein Expression
    REFSEQ proteins: NP_599030.1  
    ENSEMBL proteins: 
     ENSP00000293230   ENSP00000466448   ENSP00000464817   ENSP00000468559  

    Human Recombinant Protein Products for CYGB: 
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    OriGene Protein Over-expression Lysate for CYGB
    OriGene MassSpec for CYGB 
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    GenScript Custom Purified and Recombinant Proteins Services for CYGB
    Novus Biologicals CYGB Proteins
    Novus Biologicals CYGB Lysates
    Sino Biological Recombinant Protein for CYGB
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for CYGB
    Cloud-Clone Corp. Proteins for CYGB 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0043005neuron projection IEA--
    GO:0043025neuronal cell body IEA--

    CYGB for ontologies           About GeneDecksing



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    Cloud-Clone Corp. ELISAs for CYGB 
    Cloud-Clone Corp. CLIAs for CYGB


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR012292 Globin_dom
     IPR009050 Globin-like
     IPR013314 Globin_lamprey/hagfish
     IPR000971 Globin

    Graphical View of Domain Structure for InterPro Entry Q8WWM9

    ProtoNet protein and cluster: Q8WWM9

    1 Blocks protein domain: IPB002335 Myoglobin signature

    UniProtKB/Swiss-Prot: CYGB_HUMAN, Q8WWM9
    Similarity: Belongs to the globin family


    CYGB for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CYGB_HUMAN, Q8WWM9
    Function: May have a protective function during conditions of oxidative stress. May be involved in intracellular
    oxygen storage or transfer

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004601peroxidase activity ISS11320098
    GO:0005344oxygen transporter activity NAS11919282
    GO:0005506iron ion binding IEA--
    GO:0019825oxygen binding IEA--
    GO:0020037heme binding IEA--
         
    CYGB for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CYGB:
     Increased HPV18 LCR reporter a 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Cygb):
     homeostasis/metabolism  liver/biliary system  tumorigenesis 

    CYGB for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Cygbtm1Nka for CYGB

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CYGB 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CYGB

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CYGB 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CYGB 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CYGB
    8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate CYGB (see all 17):
    hsa-miR-576-3p hsa-miR-520d-5p hsa-miR-766 hsa-miR-29b-1* hsa-miR-3150a-3p hsa-miR-4267 hsa-miR-409-5p hsa-miR-193a-5p
    SwitchGear 3'UTR luciferase reporter plasmidCYGB 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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                         Customized lentivirus expression plasmids for stable overexpression of CYGB 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYGB


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CYGB

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for CYGB (ENSP000002932304) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HBBENSP000003339944STRING: ENSP00000333994
    SH3KBP1ENSP000003809214STRING: ENSP00000380921
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006979response to oxidative stress ISS11320098
    GO:0015671oxygen transport NAS11919282

    CYGB for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CYGB for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CYGB

    2 HMDB Compounds for CYGB    About this table
    CompoundSynonyms CAS #PubMed Ids
    Heme(protoporphyrinato)iron (see all 19)14875-96-8--
    OxygenOxygen (see all 5)7782-44-7--

    1 DrugBank Compound for CYGB    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Heme-- --target--10592235

    8 Novoseek inferred chemical compound relationships for CYGB gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    fe2+ 69.1 5 18599123 (3), 15804830 (1), 16201751 (1)
    oxygen 51.8 17 19001220 (3), 17532579 (3), 18574250 (2), 15299006 (1) (see all 9)
    histidine 47.8 4 16201751 (2), 14530264 (1)
    xenon 34.6 2 15963643 (1), 15044115 (1)
    nitric oxide 19.5 6 19147491 (4)
    iron 19.1 2 16825958 (1)
    h2o2 13.9 2 17476593 (1), 18940239 (1)
    cysteine 4.02 3 15036292 (1), 19052772 (1), 14530264 (1)

    Search CenterWatch for drugs/clinical trials and news about CYGB

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CYGB gene: 
    NM_134268.4  

    Unigene Cluster for CYGB:

    Cytoglobin
    Hs.95120  [show with all ESTs]
    Unigene Representative Sequence: NM_134268
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000293230(uc002jru.1) ENST00000586160 ENST00000589342 ENST00000590175
    ENST00000589145
    miRNA
    Products:
         
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    8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate CYGB (see all 17):
    hsa-miR-576-3p hsa-miR-520d-5p hsa-miR-766 hsa-miR-29b-1* hsa-miR-3150a-3p hsa-miR-4267 hsa-miR-409-5p hsa-miR-193a-5p
    SwitchGear 3'UTR luciferase reporter plasmidCYGB 3' UTR sequence
    Inhib. RNA
    Products:
         
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CYGB
    Clone
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    OriGene clones in human, mouse for CYGB (see all 7)
    OriGene ORF clones in mouse, rat for CYGB
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    GenScript: all cDNA clones in your preferred vector: CYGB (NM_134268)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CYGB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CYGB
    Sirion Biotech Customized lentivirus for stable overexpression of CYGB 
                         Customized lentivirus expression plasmids for stable overexpression of CYGB 
    Primer
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    OriGene qPCR primer pairs and template standards for CYGB
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CYGB
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CYGB

    Additional mRNA sequence: 

    AB057769.1 AJ315162.1 AK098057.1 BC029798.1 BX647425.1 

    5 DOTS entries:

    DT.113708  DT.100780030  DT.439541  DT.99968658  DT.99975546 

    24/128 AceView cDNA sequences (see all 128):

    AI141887 BU683447 BM704770 BM823189 AI749202 BQ719886 CA426049 AJ315162 
    CR615530 N50098 BE313504 BU181112 AA371897 BQ638513 CR604289 BQ881744 
    BM717594 CD671184 NM_134268 CD671183 BU150491 BM925061 AB057769 BU730333 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CYGB expression in normal human tissues (normalized intensities)      CYGB embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTGGGTCTC
    CYGB Expression
    About this image


    CYGB expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/9 selected tissues (see all 9) fully expand
     
     Uncategorized (Uncategorized)    fully expand to see all 2 entries
             PureStem progenitor RP1-MV2-8
     
     Smooth Muscle (Muscoskeletal System)
             Human Colonic Smooth Muscle Cells (HCoSMC)   
     
     Colon (Gastrointestinal Tract)
             Human Colonic Smooth Muscle Cells (HCoSMC)   
     
     Neural Crest (Gastrulation Derivatives)
             PureStem 7PEND24, NCr-fac & Meso-prx Progenitor
     
     Paraxial Mesoderm (Gastrulation Derivatives)
             PureStem 7PEND24, NCr-fac & Meso-prx Progenitor

    See CYGB Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CYGB

    SOURCE GeneReport for Unigene cluster: Hs.95120

    UniProtKB/Swiss-Prot: CYGB_HUMAN, Q8WWM9
    Tissue specificity: Ubiquitously expressed. Highest expression in heart, stomach, bladder and small intestine

        SABiosciences Expression via Pathway-Focused PCR Arrays including CYGB: 
              Oxidative Stress in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYGB

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CYGB gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cygb1 , 5 cytoglobin1, 5 92.81(n)1
    95.26(a)1
      11 (81.45 cM)5
    1148861  NM_030206.41  NP_084482.11 
     1166455955 
    chicken
    (Gallus gallus)
    Aves CYGB1 cytoglobin 78.65(n)
    77.53(a)
      427802  NM_001008789.1  NP_001008789.1 
    lizard
    (Anolis carolinensis)
    Reptilia CYGB6
    cytoglobin
    66(a)
    1 ↔ 1
    2(112013087-112080780)
    zebrafish
    (Danio rerio)
    Actinopterygii cygb2 cytoglobin 73.1(n)   246090  AJ320232.1 


    ENSEMBL Gene Tree for CYGB (if available)
    TreeFam Gene Tree for CYGB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CYGB gene
    MB2  
    10 SIMAP similar genes for CYGB using alignment to 3 protein entries:     CYGB_HUMAN (see all proteins):
    HBE1    HBG1    HBG2    HBD    HBB    HBZ
    MB    HBA1    HBA2    HBQ1

    CYGB for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section
    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CYGB:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv908831CNV Loss21882294
    nsv833549CNV Gain17160897

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CYGB
    DNA2.0 Custom Variant and Variant Library Synthesis for CYGB

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608759    OMIM disorders: --

    20/23 diseases for CYGB (see all 23):    About MalaCards
    hereditary neuralgic amyotrophy    nutrition disease    anoxia    alveolar soft part sarcoma
    acute chest syndrome    keratoderma    cerebral artery occlusion    diarrhea
    oral cancer    hypoxia    thalassemia    retinitis
    kidney disease    neuroblastoma    sarcoma    lung cancer
    anemia    cerebritis    adenocarcinoma    neuronitis

    4 diseases from the University of Copenhagen DISEASES database for CYGB:
    Anemia     Kidney disease     Nutrition disease     Nonepidermolytic palmoplantar keratoderma

    CYGB for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for CYGB gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer lung 0 7 18794132 (2), 16677525 (1)
    tumors 0 12 18794132 (5), 16677525 (2), 18714394 (1)
    cancer 0 5 19568272 (2), 16449996 (1), 16698880 (1)


    Export disorders for CYGB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CYGB gene, integrated from 9 sources (see all 97):
    (articles sorted by number of sources associating them with CYGB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cytoglobin: a novel globin type ubiquitously expressed in vertebrate tissues. (PubMed id 11919282)1, 2, 3, 9 Burmester T.... Hankeln T. (2002)
    2. Crystal structure of cytoglobin: the fourth globin type discovered in man displays heme hexa-coordination. (PubMed id 15095869)1, 2, 9 de Sanctis D.... Bolognesi M. (2004)
    3. High-resolution structure of human cytoglobin: identification of extra N-and C-termini and a new dimerization mode. (PubMed id 16699195)1, 2, 9 Makino M.... Shiro Y. (2006)
    4. Structural basis of human cytoglobin for ligand binding. (PubMed id 15165856)1, 2, 9 Sugimoto H....Shiro Y. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. A ubiquitously expressed human hexacoordinate hemoglobin. (PubMed id 11893755)1, 2 Trent J.T. III and Hargrove M.S. (2002)
    8. Characterization of human stellate cell activation-associated protein and its expression in human liver. (PubMed id 12359339)1, 2 Asahina K.... Yoshizato K. (2002)
    9. Cytoglobin, the newest member of the globin family, functions as a tumor suppressor gene. (PubMed id 18794132)1, 9 Shivapurkar N....Gazdar A.F. (2008)
    10. Cytoglobin is upregulated by tumour hypoxia and silen ced by promoter hypermethylation in head and neck cancer. (PubMed id 19568272)1, 9 Shaw R.J....Risk J.M. (2009)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 114757 HGNC: 16505 AceView: CYGB Ensembl:ENSG00000161544 euGenes: HUgn114757
    ECgene: CYGB H-InvDB: CYGB

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CYGB Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CYGB gene:
    Search GeneIP for patents involving CYGB

    GeneCards and IP:
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