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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CYGB Gene

protein-coding   GIFtS: 51
GCID: GC17M074523

cytoglobin
 Explore 20 diseases affiliated with
CYGB via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CYGB    

Aliases
for CYGB gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Cytoglobin1     Histoglobin3
STAP1 2 3 5     HGb3
HGB1 2 5     Histoglobin3
Stellate Cell Activation-Associated Protein2 3     

External Ids:    HGNC: 165051   Entrez Gene: 1147572   Ensembl: ENSG000001615447   OMIM: 6087595   UniProtKB: Q8WWM93   

Export aliases for CYGB gene to outside databases

Previous GC identifers: GC17M074357 GC17M077515 GC17M074987 GC17M075120 GC17M072035 GC17M069951


Summaries
for CYGB gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CYGB:
This gene encodes a globin protein found in vertebrate cells. The encoded protein is described as a hexacoordinate
hemoglobin which binds ligand differently from the pentacoordinate hemoglobins involved in oxygen transport, and may
be involved in protection during oxidative stress. This gene is located on chromosome 17 in the same region as a
retinal gene which is mutated in progressive rod-cone degeneration, but in the opposite orientation. (provided by
RefSeq, Jan 2012)

UniProtKB/Swiss-Prot: CYGB_HUMAN, Q8WWM9
Function: May have a protective function during conditions of oxidative stress. May be involved in intracellular oxygen
storage or transfer

Gene Wiki entry for CYGB (Cytoglobin)


Genomic Views
for CYGB gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CYGB gene promoter:
         GATA-3   Sp1   RelA   XBP-1   HNF-3beta   Egr-2   ZIC2/Zic2   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CYGB promoter sequence
   Search SABiosciences Chromatin IP Primers for CYGB

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CYGB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25   Ensembl cytogenetic band:  17q25.1   HGNC cytogenetic band: 17q25

CYGB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CYGB gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M074523:  view genomic region     (about GC identifiers)

Start:
 74,523,438 bp from pter      End:
 74,547,257 bp from pter
Size:
 23,820 bases      Orientation:
 minus strand

Proteins
for CYGB gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CYGB_HUMAN, Q8WWM9 (See protein sequence)
Recommended Name: Cytoglobin  
Size: 190 amino acids; 21405 Da
Subunit: Homodimer; disulfide-linked
Subcellular location: Cytoplasm (By similarity)
6/9 PDB 3D structures from and Proteopedia for CYGB (see all 9):
1UMO (3D)        1URV (3D)        1URY (3D)        1UT0 (3D)        1UX9 (3D)        1V5H (3D)    
Secondary accessions: Q541Y7 Q8N2X5

Explore the universe of human proteins at neXtProt for CYGB: NX_Q8WWM9

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8WWM9

    • CYGB Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_599030.1  
    ENSEMBL proteins: 
     ENSP00000293230   ENSP00000466448   ENSP00000464817   ENSP00000468559  

    Human Recombinant Protein Products: 
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    OriGene Purified Protein: CYGB
    OriGene Protein Over-expression Lysate: CYGB
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    Novus Biologicals CYGB Proteins
    Novus Biologicals CYGB Lysates
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for CYGB
    Uscn Proteins for CYGB

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0043005neuron projection IEA--
    GO:0043025neuronal cell body IEA--


    CYGB for ontologies           About GeneDecksing



    CYGB Antibody Products: 
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    Uscn Antibodies for CYGB
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    Assay Products for CYGB: 
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    Uscn ELISAs and CLIAs for CYGB

    Protein Domains /
    Families
    for CYGB gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CYGB for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR012292 Globin_dom
     IPR009050 Globin-like
     IPR013314 Globin_lamprey/hagfish
     IPR000971 Globin

    Graphical View of Domain Structure for InterPro Entry Q8WWM9

    ProtoNet protein and cluster: Q8WWM9

    1 Blocks protein family: IPB002335 Myoglobin signature

    UniProtKB/Swiss-Prot: CYGB_HUMAN, Q8WWM9
    Similarity: Belongs to the globin family


    Function
    for CYGB gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CYGB_HUMAN, Q8WWM9
    Function: May have a protective function during conditions of oxidative stress. May be involved in intracellular oxygen
    storage or transfer

    miRNA
    Products:            		 OriGene 3'-UTR Clone: CYGB
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CYGB
    8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate CYGB (see all 17):
    hsa-miR-576-3p hsa-miR-520d-5p hsa-miR-766 hsa-miR-29b-1* hsa-miR-3150a-3p hsa-miR-4267 hsa-miR-409-5p hsa-miR-193a-5p
    SwitchGear 3'UTR luciferase reporter plasmid: CYGB 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CYGB (see all 7)
    OriGene shRNA RFP: CYGB
    OriGene siRNA: CYGB
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CYGB

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for CYGB

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CYGB (see all 3)
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    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for CYGB
    Search LifeMap BioReagents cell lines for CYGB

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYGB

    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004601peroxidase activity ISS11320098
    GO:0005344oxygen transporter activity NAS11919282
    GO:0005506iron ion binding IEA--
    GO:0019825oxygen binding IEA--
    GO:0020037heme binding IEA--


    CYGB for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for CYGB:
     Increased HPV18 LCR reporter a 

    Animal Models:
         Mouse knock-out Cygbtm1Nka for CYGB
         3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Cygb):
     homeostasis/metabolism  liver/biliary system  tumorigenesis 

    CYGB for phenotypes           About GeneDecksing


    Pathways & Interactions
    for CYGB gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CYGB

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for CYGB (ENSP000002932304) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HBBENSP000003339944STRING: ENSP00000333994
    SH3KBP1ENSP000003809214STRING: ENSP00000380921
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006979response to oxidative stress ISS11320098
    GO:0015671oxygen transport NAS11919282


    CYGB for ontologies           About GeneDecksing



    Drugs & Compounds
    for CYGB gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CYGB for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CYGB

    2 HMDB Compounds for CYGB    About this table
    CompoundSynonyms CAS #PubMed Ids
    Heme(protoporphyrinato)iron (see all 19)14875-96-8--
    OxygenOxygen (see all 5)7782-44-7--

    1 DrugBank Compound for CYGB    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Heme-- --target--10592235

    8 Novoseek chemical compound relationships for CYGB gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    fe2+ 69.1 5 18599123 (3), 15804830 (1), 16201751 (1)
    oxygen 51.8 17 19001220 (3), 17532579 (3), 18574250 (2), 15299006 (1) (see all 9)
    histidine 47.8 4 16201751 (2), 14530264 (1)
    xenon 34.6 2 15963643 (1), 15044115 (1)
    nitric oxide 19.5 6 19147491 (4)
    iron 19.1 2 16825958 (1)
    h2o2 13.9 2 17476593 (1), 18940239 (1)
    cysteine 4.02 3 15036292 (1), 19052772 (1), 14530264 (1)

    Search CenterWatch for drugs/clinical trials and news about CYGB 

    Transcripts
    for CYGB gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CYGB gene: 
    NM_134268.4  

    Unigene Cluster for CYGB:

    Cytoglobin
    Hs.95120  [show with all ESTs]
    Unigene Representative Sequence: NM_134268
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000293230(uc002jru.1) ENST00000586160 ENST00000589342 ENST00000590175
    ENST00000589145

    miRNA
    Products:             		 OriGene 3'-UTR Clone: CYGB
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CYGB
    8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate CYGB (see all 17):
    hsa-miR-576-3p hsa-miR-520d-5p hsa-miR-766 hsa-miR-29b-1* hsa-miR-3150a-3p hsa-miR-4267 hsa-miR-409-5p hsa-miR-193a-5p
    SwitchGear 3'UTR luciferase reporter plasmid: CYGB 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CYGB (see all 7)
    OriGene shRNA RFP: CYGB
    OriGene siRNA: CYGB
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CYGB
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CYGB (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CYGB
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: CYGB (NM_134268)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CYGB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CYGB 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CYGB
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CYGB
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CYGB
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CYGB

    Additional cDNA sequence: 

    AB057769.1 AJ315162.1 AK098057.1 BC029798.1 BX647425.1 

    5 DOTS entries:

    DT.113708  DT.100780030  DT.439541  DT.99968658  DT.99975546 

    24/128 AceView cDNA sequences (see all 128):

    BM823189 AA371897 N50098 CA426049 BE313504 CF131380 CR604289 BQ881744 
    CR626663 CR596351 AB057769 BQ638513 BM717594 BU730333 BQ719886 AK098057 
    CD671184 NM_134268 CD671183 CR615530 AI141887 BU683447 BU181112 BM704770 

    GeneLoc Exon Structure


    Expression
    for CYGB gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CYGB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CCTGGGTCTC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    CYGB expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 4 LifeMap Cells 
    NameCategory
    PureStem™ myogenic progenitor Z11 (Embryonic Progenitor Cell)Heart, Myocardium, Smooth Muscle
    PureStem™ mesenchymal progenitor 7PEND24 (Embryonic Progenitor Cell)Cartilage, Neural Crest
    PureStem™ progenitor EN27 (Embryonic Progenitor Cell)
    PureStem™ progenitor W8 (Embryonic Progenitor Cell)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See CYGB Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CYGB

    SOURCE GeneReport for Unigene cluster: Hs.95120

    UniProtKB/Swiss-Prot: CYGB_HUMAN, Q8WWM9
    Tissue specificity: Ubiquitously expressed. Highest expression in heart, stomach, bladder and small intestine

        SABiosciences Expression via Pathway-Focused PCR Arrays including CYGB: 
              Oxidative Stress in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CYGB
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYGB

    Orthologs
    for CYGB gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for CYGB gene from 3/11 species (see all 11)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves CYGB1 cytoglobin 78.65(n)
    77.53(a)    		   427802  NM_001008789.1  NP_001008789.1 
    lizard
    (Anolis carolinensis)    		 Reptilia CYGB6
    		 --
    		 75(a)
    		 1 ↔ 1
    		 2(112047533-112050745)
    zebrafish
    (Danio rerio)    		 Actinopterygii cygb2 cytoglobin 73.1(n)   246090  AJ320232.1 


    ENSEMBL Gene Tree for CYGB (if available)
    TreeFam Gene Tree for CYGB (if available) 

    Paralogs
    for CYGB gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CYGB gene
    HBG22  HBE12  HBZ2  HBD2  HBG12  HBA22  HBB2  HBQ12  
    HBA12  HBM2  
    10 SIMAP similar genes for CYGB using alignment to 3 protein entries:     CYGB_HUMAN (see all proteins):
    HBE1    HBG1    HBG2    HBD    HBB    HBZ
    MB    HBA1    HBA2    HBQ1

    CYGB for paralogs           About GeneDecksing



    Genomic Variants
    for CYGB gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/219 NCBI SNPs in CYGB are shown (see all 219)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 17 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1135269541,2
    		C,F--69950704(+) CCTTGG/TTGTGG 1 -- us2k12Minor allele frequency- T:0.50NA WA 4
    rs1123485951,2
    		C,F--69950781(+) TGGGGC/TGCCCT 1 -- us2k12Minor allele frequency- T:0.50NA WA 4
    rs114251,2
    		C--69951117(-) ATGTTT/GGTAAC 1 -- us2k13Minor allele frequency- G:0.00MN NA 188
    rs1132888871,2
    		--69951673(+) CCCAGC/ACCTGC 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs118710591,2
    		C,F,H,--69951807(+) CGCCGC/TGGATA 1 -- int1 ese34Minor allele frequency- T:0.18NA CSA WA 127
    rs2013037821,2
    		C--69952139(-) GGTCCC/TCCCCT 1 -- int10--------
    rs42389951,2
    		C,A,H--69952284(+) TGGAGG/GG    
           /T/TT    TAGGG     		1 -- int10--------
    rs733653811,2
    		C,--69952401(+) GAGGAC/TCTGGG 1 -- int11Minor allele frequency- T:0.50WA 2
    rs1141597371,2
    		C,F,--69952699(+) CTCCTC/TGGGCC 1 -- int11Minor allele frequency- T:0.08WA 118
    rs772653801,2
    		--69954369(+) TTACCG/ACCAGG 1 -- int12Minor allele frequency- A:0.07CSA WA 120

    HapMap Linkage Disequilibrium report for CYGB (74523438 - 74547257 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for CYGB: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CYGB
    DNA2.0 Custom Variant and Variant Library Synthesis for CYGB

    Disorders / Diseases
    for CYGB gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CYGB for disorders           About GeneDecksing

    OMIM gene information: 608759    OMIM disorders: --

    20 diseases for CYGB:    About MalaCards
    hereditary neuralgic amyotrophy    nonepidermolytic palmoplantar keratoderma    alveolar soft part sarcoma    retinol binding protein
    acute chest syndrome    keratoderma    anoxia    retinitis
    thalassemia    diarrhea    oral cancer    sarcoma
    lung cancer    breast cancer    fibrosis    hypoxia
    neuroblastoma    hepatitis    neuronitis    liver fibrosis

    4 diseases from the University of Copenhagen DISEASES database for CYGB:
    Anemia     Kidney disease     Nutrition disease     Nonepidermolytic palmoplantar keratoderma

    3 Novoseek disease relationships for CYGB gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer lung 0 7 18794132 (2), 16677525 (1)
    tumors 0 12 18794132 (5), 16677525 (2), 18714394 (1)
    cancer 0 5 19568272 (2), 16449996 (1), 16698880 (1)


    Export disorders for CYGB gene to outside databases

    Publications
    for CYGB gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CYGB gene, integrated from 9 sources (see all 94):
    (articles sorted by number of sources associating them with CYGB)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cytoglobin: a novel globin type ubiquitously expressed in vertebrate tissues. (PubMed id 11919282)1, 2, 3, 9 Burmester T.... Hankeln T. (2002)
    2. Crystal structure of cytoglobin: the fourth globin type discovered in man displays heme hexa-coordination. (PubMed id 15095869)1, 2, 9 de Sanctis D.... Bolognesi M. (2004)
    3. High-resolution structure of human cytoglobin: identification of extra N-and C-termini and a new dimerization mode. (PubMed id 16699195)1, 2, 9 Makino M.... Shiro Y. (2006)
    4. Structural basis of human cytoglobin for ligand binding. (PubMed id 15165856)1, 2, 9 Sugimoto H....Shiro Y. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. A ubiquitously expressed human hexacoordinate hemoglobin. (PubMed id 11893755)1, 2 Trent J.T. III and Hargrove M.S. (2002)
    8. Characterization of human stellate cell activation-associated protein and its expression in human liver. (PubMed id 12359339)1, 2 Asahina K.... Yoshizato K. (2002)
    9. Cytoglobin, the newest member of the globin family, functions as a tumor suppressor gene. (PubMed id 18794132)1, 9 Shivapurkar N....Gazdar A.F. (2008)
    10. Cytoglobin is upregulated by tumour hypoxia and silen ced by promoter hypermethylation in head and neck cancer. (PubMed id 19568272)1, 9 Shaw R.J....Risk J.M. (2009)

    External Searches for CYGB gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing CYGB gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 114757 HGNC: 16505 AceView: CYGB Ensembl:ENSG00000161544 euGenes: HUgn114757
    ECgene: CYGB H-InvDB: CYGB

    Other Databases showing CYGB gene

    (According to HUGE)
    About This Section
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    Specialized Databases showing CYGB gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CYGB Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for CYGB gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CYGB gene:
    Search GeneIP for patents involving CYGB

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