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CYGB Gene

protein-coding   GIFtS: 53
GCID: GC17M074523

Cytoglobin

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
cytoglobin1 2     HGB2 5
Stellate Cell Activation-Associated Protein1 2 3     HGb3
STAP2 3 5     Histoglobin3
histoglobin1 2     

External Ids:    HGNC: 165051   Entrez Gene: 1147572   Ensembl: ENSG000001615447   OMIM: 6087595   UniProtKB: Q8WWM93   

Export aliases for CYGB gene to outside databases

Previous GC identifers: GC17M074357 GC17M077515 GC17M074987 GC17M075120 GC17M072035 GC17M069951


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CYGB Gene:
This gene encodes a globin protein found in vertebrate cells. The encoded protein is described as a hexacoordinate
hemoglobin which binds ligand differently from the pentacoordinate hemoglobins involved in oxygen transport, and
may be involved in protection during oxidative stress. This gene is located on chromosome 17 in the same region
as a retinal gene which is mutated in progressive rod-cone degeneration, but in the opposite orientation.
(provided by RefSeq, Jan 2012)

GeneCards Summary for CYGB Gene:
CYGB (cytoglobin) is a protein-coding gene. Diseases associated with CYGB include hereditary neuralgic amyotrophy, and anoxia. GO annotations related to this gene include iron ion binding and oxygen binding. An important paralog of this gene is MB.

UniProtKB/Swiss-Prot: CYGB_HUMAN, Q8WWM9
Function: May have a protective function during conditions of oxidative stress. May be involved in intracellular
oxygen storage or transfer

Gene Wiki entry for CYGB (Cytoglobin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NT_010783.16  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CYGB gene promoter:
         GATA-3   Sp1   RelA   XBP-1   HNF-3beta   Egr-2   ZIC2/Zic2   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCYGB promoter sequence
   Search Chromatin IP Primers for CYGB

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CYGB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25   Ensembl cytogenetic band:  17q25.1   HGNC cytogenetic band: 17q25

CYGB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CYGB gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M074523:  view genomic region     (about GC identifiers)

Start:
74,523,438 bp from pter      End:
74,547,257 bp from pter
Size:
23,820 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CYGB_HUMAN, Q8WWM9 (See protein sequence)
Recommended Name: Cytoglobin  
Size: 190 amino acids; 21405 Da
Subunit: Homodimer; disulfide-linked
Selected PDB 3D structures from and Proteopedia for CYGB (see all 9):
1UMO (3D)        1URV (3D)        1URY (3D)        1UT0 (3D)        1UX9 (3D)        1V5H (3D)    
Secondary accessions: Q541Y7 Q8N2X5

Explore the universe of human proteins at neXtProt for CYGB: NX_Q8WWM9

Explore proteomics data for CYGB at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CYGB Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_599030.1  
    ENSEMBL proteins: 
     ENSP00000293230   ENSP00000466448   ENSP00000464817   ENSP00000468559  

    CYGB Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Purified Protein for CYGB
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    OriGene MassSpec for CYGB
    OriGene Custom Protein Services for CYGB
    GenScript Custom Purified and Recombinant Proteins Services for CYGB
    Novus Biologicals CYGB Proteins
    Novus Biologicals CYGB Lysate
    Sino Biological Recombinant Protein for CYGB
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for CYGB
    Cloud-Clone Corp. Proteins for CYGB

    CYGB Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
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    Novus Biologicals CYGB Antibodies
    Abcam antibodies for CYGB
    Cloud-Clone Corp. Antibodies for CYGB
    ThermoFisher Antibody for CYGB
    LSBio Antibodies in human, mouse, rat for CYGB

    CYGB Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CYGB
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CYGB
    Cloud-Clone Corp. CLIAs for CYGB


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR012292 Globin_dom
     IPR009050 Globin-like
     IPR013314 Globin_lamprey/hagfish
     IPR000971 Globin

    Graphical View of Domain Structure for InterPro Entry Q8WWM9

    ProtoNet protein and cluster: Q8WWM9

    1 Blocks protein domain: IPB002335 Myoglobin signature

    UniProtKB/Swiss-Prot: CYGB_HUMAN, Q8WWM9
    Similarity: Belongs to the globin family


    CYGB for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CYGB_HUMAN, Q8WWM9
    Function: May have a protective function during conditions of oxidative stress. May be involved in intracellular
    oxygen storage or transfer

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004601peroxidase activity ISS11320098
    GO:0005344oxygen transporter activity NAS11919282
    GO:0005506iron ion binding IEA--
    GO:0019825oxygen binding IEA--
    GO:0020037heme binding IEA--
         
    CYGB for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CYGB:
     Increased HPV18 LCR reporter a 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Cygb):
     homeostasis/metabolism  liver/biliary system  tumorigenesis 

    CYGB for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Cygbtm1Nka for CYGB

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CYGB
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CYGB

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CYGB
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CYGB

    miRNA
    Products:
        
    miRTarBase miRNAs that target CYGB:
    hsa-mir-335-5p (MIRT016773)

    Block miRNA regulation of human, mouse, rat CYGB using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CYGB (see all 17):
    hsa-miR-576-3p hsa-miR-520d-5p hsa-miR-766 hsa-miR-29b-1* hsa-miR-3150a-3p hsa-miR-4267 hsa-miR-409-5p hsa-miR-193a-5p
    SwitchGear 3'UTR luciferase reporter plasmidCYGB 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CYGB
    Predesigned siRNA for gene silencing in human, mouse, rat CYGB

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CYGB

    Clone
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    OriGene clones in human, mouse for CYGB (see all 6)
    OriGene ORF clones in mouse, rat for CYGB
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CYGB (NM_134268)
    Sino Biological Human cDNA Clone for CYGB
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CYGB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CYGB

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CYGB
    Browse ESI BIO Cell Lines and PureStem Progenitors for CYGB 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYGB


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CYGB_HUMAN, Q8WWM9: Cytoplasm (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    extracellular2
    nucleus2
    mitochondrion1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0043005neuron projection IEA--
    GO:0043025neuronal cell body IEA--

    CYGB for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Arrays including CYGB: 
              Oxidative Stress in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for CYGB

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for CYGB (ENSP000002932304) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HBBENSP000003339944STRING: ENSP00000333994
    SH3KBP1ENSP000003809214STRING: ENSP00000380921
    AANATENSP000002506154STRING: ENSP00000250615
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006979response to oxidative stress ISS11320098
    GO:0015671oxygen transport NAS11919282
    GO:0055114oxidation-reduction process ISS11320098

    CYGB for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CYGB

    2 HMDB Compounds for CYGB    About this table
    CompoundSynonyms CAS #PubMed Ids
    Heme(protoporphyrinato)iron (see all 19)14875-96-8--
    OxygenOxygen (see all 5)7782-44-7--

    1 DrugBank Compound for CYGB    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Heme-- --target--10592235

    8 Novoseek inferred chemical compound relationships for CYGB gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    fe2+ 69.1 5 18599123 (3), 15804830 (1), 16201751 (1)
    oxygen 51.8 17 19001220 (3), 17532579 (3), 18574250 (2), 15299006 (1) (see all 9)
    histidine 47.8 4 16201751 (2), 14530264 (1)
    xenon 34.6 2 15963643 (1), 15044115 (1)
    nitric oxide 19.5 6 19147491 (4)
    iron 19.1 2 16825958 (1)
    h2o2 13.9 2 17476593 (1), 18940239 (1)
    cysteine 4.02 3 15036292 (1), 19052772 (1), 14530264 (1)



    CYGB for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CYGB gene: 
    NM_134268.4  

    Unigene Cluster for CYGB:

    Cytoglobin
    Hs.95120  [show with all ESTs]
    Unigene Representative Sequence: NM_134268
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000293230(uc002jru.1) ENST00000586160 ENST00000589342 ENST00000590175
    ENST00000589145
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CYGB using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CYGB (see all 17):
    hsa-miR-576-3p hsa-miR-520d-5p hsa-miR-766 hsa-miR-29b-1* hsa-miR-3150a-3p hsa-miR-4267 hsa-miR-409-5p hsa-miR-193a-5p
    SwitchGear 3'UTR luciferase reporter plasmidCYGB 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CYGB
    Predesigned siRNA for gene silencing in human, mouse, rat CYGB
    Clone
    Products:
         
    OriGene clones in human, mouse for CYGB (see all 6)
    OriGene ORF clones in mouse, rat for CYGB
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CYGB (NM_134268)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CYGB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CYGB
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CYGB
    OriGene qSTAR qPCR primer pairs in human, mouse for CYGB
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CYGB
      QuantiTect SYBR Green Assays in human, mouse, rat CYGB
      QuantiFast Probe-based Assays in human, mouse, rat CYGB

    Additional mRNA sequence: 

    AB057769.1 AJ315162.1 AK098057.1 BC029798.1 BX647425.1 

    5 DOTS entries:

    DT.113708  DT.100780030  DT.439541  DT.99968658  DT.99975546 

    Selected AceView cDNA sequences (see all 128):

    AI749202 AJ315162 BM925061 BU683447 CR615530 AB057769 BM704770 BQ881744 
    BU730333 BM717594 CD671184 CR626663 BU181112 BQ719886 CR596351 BQ638513 
    CR604289 NM_134268 BE313504 BU150491 AA371897 CD671183 CF131380 AK098057 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CYGB expression in normal human tissues (normalized intensities)      CYGB embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTGGGTCTC
    CYGB Expression
    About this image


    CYGB expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Paraxial Mesoderm (Gastrulation Derivatives)
             PureStem 7PEND24, NCr-fac & Meso-prx Progenitor
     
     Neural Crest (Gastrulation Derivatives)
             PureStem 7PEND24, NCr-fac & Meso-prx Progenitor
    CYGB Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CYGB Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.95120

    UniProtKB/Swiss-Prot: CYGB_HUMAN, Q8WWM9
    Tissue specificity: Ubiquitously expressed. Highest expression in heart, stomach, bladder and small intestine

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CYGB: 
              Oxidative Stress in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CYGB
    OriGene qSTAR qPCR primer pairs in human, mouse for CYGB
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CYGB
    QuantiTect SYBR Green Assays in human, mouse, rat CYGB
    QuantiFast Probe-based Assays in human, mouse, rat CYGB
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYGB

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CYGB gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cygb1 , 5 cytoglobin1, 5 92.81(n)1
    95.26(a)1
      11 (81.45 cM)5
    1148861  NM_030206.41  NP_084482.11 
     1166455955 
    chicken
    (Gallus gallus)
    Aves CYGB1 cytoglobin 78.65(n)
    77.53(a)
      427802  NM_001008789.1  NP_001008789.1 
    lizard
    (Anolis carolinensis)
    Reptilia CYGB6
    cytoglobin
    65(a)
    1 ↔ 1
    2(112013087-112080780)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia cygb1 cytoglobin 71.35(n)
    69.66(a)
      448640  NM_001006869.1  NP_001006870.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cygb2 cytoglobin 73.1(n)   246090  AJ320232.1 


    ENSEMBL Gene Tree for CYGB (if available)
    TreeFam Gene Tree for CYGB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CYGB gene
    MB2  
    10 SIMAP similar genes for CYGB using alignment to 3 protein entries:     CYGB_HUMAN (see all proteins):
    HBE1    HBG1    HBG2    HBD    HBB    HBZ
    MB    HBA1    HBA2    HBQ1

    CYGB for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CYGB:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv908831CNV Loss21882294
    nsv833549CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CYGB
    DNA2.0 Custom Variant and Variant Library Synthesis for CYGB

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608759    OMIM disorders: --

    Selected diseases for CYGB (see all 22):    About MalaCards
    hereditary neuralgic amyotrophy    anoxia    alveolar soft part sarcoma    cerebral artery occlusion
    acute chest syndrome    keratoderma    diarrhea    oral cancer
    hypoxia    thalassemia    retinitis    neuroblastoma
    cerebritis    kidney disease    sarcoma    lung cancer
    adenocarcinoma    neuronitis    breast cancer    ovarian cancer

    4 diseases from the University of Copenhagen DISEASES database for CYGB:
    Anemia     Kidney disease     Nutrition disease     Nonepidermolytic palmoplantar keratoderma

    CYGB for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for CYGB gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer lung 0 7 18794132 (2), 16677525 (1)
    tumors 0 12 18794132 (5), 16677525 (2), 18714394 (1)
    cancer 0 5 19568272 (2), 16449996 (1), 16698880 (1)


    Export disorders for CYGB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CYGB gene, integrated from 10 sources (see all 100):
    (articles sorted by number of sources associating them with CYGB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cytoglobin: a novel globin type ubiquitously expressed in vertebrate tissues. (PubMed id 11919282)1, 2, 3, 9 Burmester T.... Hankeln T. (Mol. Biol. Evol. 2002)
    2. Crystal structure of cytoglobin: the fourth globin type discovered in man displays heme hexa-coordination. (PubMed id 15095869)1, 2, 9 de Sanctis D.... Bolognesi M. (J. Mol. Biol. 2004)
    3. High-resolution structure of human cytoglobin: identification of extra N-and C-termini and a new dimerization mode. (PubMed id 16699195)1, 2, 9 Makino M.... Shiro Y. (Acta Crystallogr. D 2006)
    4. Structural basis of human cytoglobin for ligand binding. (PubMed id 15165856)1, 2, 9 Sugimoto H.... Shiro Y. (J. Mol. Biol. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. A ubiquitously expressed human hexacoordinate hemoglobin. (PubMed id 11893755)1, 2 Trent J.T. III and Hargrove M.S. (J. Biol. Chem. 2002)
    8. Characterization of human stellate cell activation-associated protein and its expression in human liver. (PubMed id 12359339)1, 2 Asahina K.... Yoshizato K. (Biochim. Biophys. Acta 2002)
    9. Cytoglobin, the newest member of the globin family, functions as a tumor suppressor gene. (PubMed id 18794132)1, 9 Shivapurkar N....Gazdar A.F. (Cancer Res. 2008)
    10. Cytoglobin is upregulated by tumour hypoxia and silenced by promoter hypermethylation in head and neck cancer. (PubMed id 19568272)1, 9 Shaw R.J....Risk J.M. (Br. J. Cancer 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Aliases
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 114757 HGNC: 16505 AceView: CYGB Ensembl:ENSG00000161544 euGenes: HUgn114757
    ECgene: CYGB H-InvDB: CYGB

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CYGB Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CYGB gene:
    Search GeneIP for patents involving CYGB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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