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Aliases for CYFIP2 Gene

Aliases for CYFIP2 Gene

  • Cytoplasmic FMR1 Interacting Protein 2 2 3
  • P53-Inducible Protein 121 3 4
  • PIR121 3 4
  • Cytoplasmic FMR1-Interacting Protein 2 3
  • P53 Inducible Protein 2
  • KIAA1168 4

External Ids for CYFIP2 Gene

Summaries for CYFIP2 Gene

GeneCards Summary for CYFIP2 Gene

CYFIP2 (Cytoplasmic FMR1 Interacting Protein 2) is a Protein Coding gene. Among its related pathways are Regulation of actin cytoskeleton and Regulation of actin cytoskeleton.

UniProtKB/Swiss-Prot for CYFIP2 Gene

  • Involved in T-cell adhesion and p53/TP53-dependent induction of apoptosis. Does not bind RNA.

Gene Wiki entry for CYFIP2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYFIP2 Gene

Genomics for CYFIP2 Gene

Genomic Location for CYFIP2 Gene

Start:
157,266,079 bp from pter
End:
157,395,598 bp from pter
Size:
129,520 bases
Orientation:
Plus strand

Genomic View for CYFIP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CYFIP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYFIP2 Gene

Regulatory Elements for CYFIP2 Gene

Proteins for CYFIP2 Gene

  • Protein details for CYFIP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96F07-CYFP2_HUMAN
    Recommended name:
    Cytoplasmic FMR1-interacting protein 2
    Protein Accession:
    Q96F07
    Secondary Accessions:
    • A6NLT2
    • D3DQJ3
    • Q53EN5
    • Q9NTK4
    • Q9ULQ2
    • Q9UN29

    Protein attributes for CYFIP2 Gene

    Size:
    1278 amino acids
    Molecular mass:
    148399 Da
    Quaternary structure:
    • Interacts with FMR1, FXR1 AND FXR2. Component of the WAVE1 complex composed of ABI2, CYFIP2, BRK1, NCKAP1 and WASF1/WAVE1. CYFIP2 binds to activated RAC1 which causes the complex to dissociate, releasing activated WASF1. The complex can also be activated by NCK1. Interacts with SHANK3; the interaction mediates the association of SHANK3 with the WAVE1 complex.
    SequenceCaution:
    • Sequence=BAA86482.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAD97324.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for CYFIP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CYFIP2 Gene

Proteomics data for CYFIP2 Gene at MOPED

Post-translational modifications for CYFIP2 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys97, Lys150, Lys197, Lys300, Lys545, Lys775, Lys903, Lys916, Lys1077, Lys1107, Lys1234, Lys1248, and Lys1251

No data available for DME Specific Peptides for CYFIP2 Gene

Domains for CYFIP2 Gene

UniProtKB/Swiss-Prot:

CYFP2_HUMAN
Family:
  • Belongs to the CYFIP family.:
    • Q96F07
genes like me logo Genes that share domains with CYFIP2: view

No data available for Gene Families for CYFIP2 Gene

Function for CYFIP2 Gene

Molecular function for CYFIP2 Gene

UniProtKB/Swiss-Prot Function: Involved in T-cell adhesion and p53/TP53-dependent induction of apoptosis. Does not bind RNA.
UniProtKB/Swiss-Prot Induction: By p53/TP53.

Gene Ontology (GO) - Molecular Function for CYFIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11438699
GO:0008009 chemokine activity --
genes like me logo Genes that share ontologies with CYFIP2: view
genes like me logo Genes that share phenotypes with CYFIP2: view

miRNA for CYFIP2 Gene

miRTarBase miRNAs that target CYFIP2

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CYFIP2 Gene

Localization for CYFIP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYFIP2 Gene

Cytoplasm. Cytoplasm, perinuclear region. Cell junction, synapse, synaptosome. Note=Highly expressed in the perinuclear region. Enriched in synaptosomes. Treatment with leptomycin-B triggers translocation to the nucleus. {ECO:0000250 UniProtKB:Q5SQX6, ECO:0000269 PubMed:10449408, ECO:0000269 PubMed:17245118}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CYFIP2 Gene COMPARTMENTS Subcellular localization image for CYFIP2 gene
Compartment Confidence
cytosol 4
nucleus 2
cytoskeleton 1
lysosome 1
mitochondrion 1
vacuole 1

Gene Ontology (GO) - Cellular Components for CYFIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region --
GO:0005737 cytoplasm IDA 11438699
GO:0005829 cytosol TAS --
GO:0016020 membrane IDA 19946888
GO:0030054 cell junction IEA --
genes like me logo Genes that share ontologies with CYFIP2: view

Pathways for CYFIP2 Gene

genes like me logo Genes that share pathways with CYFIP2: view

Gene Ontology (GO) - Biological Process for CYFIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IDA 10449408
GO:0006955 immune response --
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0016337 single organismal cell-cell adhesion IDA 15048733
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS --
genes like me logo Genes that share ontologies with CYFIP2: view

Transcripts for CYFIP2 Gene

Unigene Clusters for CYFIP2 Gene

Cytoplasmic FMR1 interacting protein 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CYFIP2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c · 11d ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^
SP1: -
SP2: - - - - -
SP3: - -
SP4: - - - - -
SP5: - - - - - - -
SP6:
SP7: - -
SP8:
SP9:
SP10:
SP11:
SP12:
SP13: - -
SP14:
SP15:
SP16:

ExUns: 20 ^ 21 ^ 22 ^ 23 ^ 24a · 24b · 24c ^ 25a · 25b ^ 26a · 26b ^ 27 ^ 28 ^ 29a · 29b ^ 30 ^ 31a · 31b ^ 32 ^ 33a · 33b · 33c ^ 34 ^ 35a · 35b · 35c ^
SP1: - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - - -
SP4:
SP5:
SP6:
SP7:
SP8: - -
SP9: -
SP10: - - - -
SP11:
SP12: - -
SP13:
SP14: -
SP15: - -
SP16:

ExUns: 36a · 36b ^ 37a · 37b · 37c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:

Relevant External Links for CYFIP2 Gene

GeneLoc Exon Structure for
CYFIP2
ECgene alternative splicing isoforms for
CYFIP2

Expression for CYFIP2 Gene

mRNA expression in normal human tissues for CYFIP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CYFIP2 Gene

This gene is overexpressed in Whole Blood (4.7).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for CYFIP2 Gene

SOURCE GeneReport for Unigene cluster for CYFIP2 Gene Hs.519702

mRNA Expression by UniProt/SwissProt for CYFIP2 Gene

Q96F07-CYFP2_HUMAN
Tissue specificity: Expressed in T-cells. Increased expression is observed in CD4(+) T-lymphocytes from patients with multiple sclerosis (at protein level).
genes like me logo Genes that share expressions with CYFIP2: view

Orthologs for CYFIP2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CYFIP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CYFIP2 36
  • 99.65 (n)
  • 100 (a)
CYFIP2 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CYFIP2 36
  • 92.36 (n)
  • 99.84 (a)
CYFIP2 37
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CYFIP2 36
  • 93.03 (n)
  • 99.92 (a)
CYFIP2 37
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cyfip2 36
  • 90.9 (n)
  • 99.92 (a)
Cyfip2 16
Cyfip2 37
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CYFIP2 37
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CYFIP2 37
  • 95 (a)
OneToOne
chicken
(Gallus gallus)
Aves CYFIP2 36
  • 86.19 (n)
  • 99.84 (a)
CYFIP2 37
  • 98 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CYFIP2 37
  • 98 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.11884 36
tropical clawed frog
(Silurana tropicalis)
Amphibia cyfip2 36
  • 82.97 (n)
  • 98.32 (a)
zebrafish
(Danio rerio)
Actinopterygii cyfip2 36
  • 83.55 (n)
  • 98.24 (a)
cyfip2 37
  • 96 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000195 36
  • 66.29 (n)
  • 67.82 (a)
fruit fly
(Drosophila melanogaster)
Insecta Sra-1 36
  • 65.86 (n)
  • 67.76 (a)
Sra-1 37
  • 64 (a)
OneToMany
Sra-1 38
  • 65 (a)
worm
(Caenorhabditis elegans)
Secernentea gex-2 37
  • 49 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons PIR121 36
  • 44.31 (n)
  • 31.6 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3302 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 64 (a)
OneToMany
Species with no ortholog for CYFIP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CYFIP2 Gene

ENSEMBL:
Gene Tree for CYFIP2 (if available)
TreeFam:
Gene Tree for CYFIP2 (if available)

Paralogs for CYFIP2 Gene

genes like me logo Genes that share paralogs with CYFIP2: view

No data available for Paralogs for CYFIP2 Gene

Variants for CYFIP2 Gene

Sequence variations from dbSNP and Humsavar for CYFIP2 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs1247 -- 157,334,597(-) caata(A/G)tatgt intron-variant
rs1248 -- 157,334,609(-) aTATG(A/T)tgata intron-variant
rs1249 -- 157,334,582(-) ctggt(A/G)atatt intron-variant
rs70529 -- 157,307,302(+) AGGAG(C/T)AGCCC intron-variant
rs163406 -- 157,265,047(+) CGGCG(C/G)CAGGA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CYFIP2 Gene

Variant ID Type Subtype PubMed ID
nsv515686 CNV Loss 19592680
nsv830526 CNV Loss 17160897

Relevant External Links for CYFIP2 Gene

HapMap Linkage Disequilibrium report
CYFIP2

Disorders for CYFIP2 Gene

Relevant External Links for CYFIP2

Genetic Association Database (GAD)
CYFIP2
Human Genome Epidemiology (HuGE) Navigator
CYFIP2
genes like me logo Genes that share disorders with CYFIP2: view

No data available for UniProtKB/Swiss-Prot for CYFIP2 Gene

Publications for CYFIP2 Gene

  1. CYFIP2 is highly abundant in CD4+ cells from multiple sclerosis patients and is involved in T cell adhesion. (PMID: 15048733) Mayne M. … Melanson M. (Eur. J. Immunol. 2004) 3 4 23
  2. Evaluation of candidate genes in a genome-wide association study of childhood asthma in Mexicans. (PMID: 19910030) Wu H. … London S.J. (J. Allergy Clin. Immunol. 2010) 3 23 49
  3. Increased apoptosis induction by 121F mutant p53. (PMID: 10449408) Saller E. … Iggo R. (EMBO J. 1999) 3 4
  4. Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PMID: 10574461) Hirosawa M. … Ohara O. (DNA Res. 1999) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for CYFIP2 Gene

Sources for CYFIP2 Gene

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