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CYFIP2 Gene

protein-coding   GIFtS: 65
GCID: GC05P156674

Cytoplasmic FMR1 Interacting Protein 2

  Search for CYFIP2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cytoplasmic FMR1 Interacting Protein 21 2
P53 Inducible Protein1 2
PIR1212 3
P53-Inducible Protein 1212 3
Cytoplasmic FMR1-Interacting Protein 22
KIAA11683

External Ids:    HGNC: 137601   Entrez Gene: 269992   Ensembl: ENSG000000551637   OMIM: 6063235   UniProtKB: Q96F073   

Export aliases for CYFIP2 gene to outside databases

Previous GC identifers: GC05P156742 GC05P157244 GC05P156628 GC05P156673 GC05P151780


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CYFIP2 Gene:
CYFIP2 (cytoplasmic FMR1 interacting protein 2) is a protein-coding gene. An important paralog of this gene is CYFIP1.

UniProtKB/Swiss-Prot: CYFP2_HUMAN, Q96F07
Function: Involved in T-cell adhesion and p53/TP53-dependent induction of apoptosis. Does not bind RNA

Gene Wiki entry for CYFIP2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NC_018916.2  NT_023133.14  
Regulatory elements:
   Regulatory transcription factor binding sites in the CYFIP2 gene promoter:
         SRY   Elk-1   POU6F1 (c2)   MRF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCYFIP2 promoter sequence
   Search Chromatin IP Primers for CYFIP2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CYFIP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q33.3   Ensembl cytogenetic band:  5q33.3   HGNC cytogenetic band: 5q34

CYFIP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CYFIP2 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P156674:  view genomic region     (about GC identifiers)

Start:
156,693,089 bp from pter      End:
156,822,606 bp from pter
Size:
129,518 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CYFP2_HUMAN, Q96F07 (See protein sequence)
Recommended Name: Cytoplasmic FMR1-interacting protein 2  
Size: 1278 amino acids; 148399 Da
Subunit: Interacts with FMR1, FXR1 AND FXR2. Component of the WAVE1 complex composed of ABI2, CYFIP2, BRK1, NCKAP1
and WASF1/WAVE1. CYFIP2 binds to activated RAC1 which causes the complex to dissociate, releasing activated
WASF1. The complex can also be activated by NCK1. Interacts with SHANK3; the interaction mediates the association
of SHANK3 with the WAVE1 complex
Rna editing: Modified_positions=320; Note=Partially edited. Editing appears to be brain-specific
Sequence caution: Sequence=BAA86482.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=BAD97324.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: A6NLT2 D3DQJ3 Q53EN5 Q9NTK4 Q9ULQ2 Q9UN29
Alternative splicing: 2 isoforms:  Q96F07-1   Q96F07-2   

Explore the universe of human proteins at neXtProt for CYFIP2: NX_Q96F07

Explore proteomics data for CYFIP2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys97, Lys150, Lys197, Lys300, Lys545, Lys775, Lys903, Lys916, Lys1077, Lys1107,
                                 Lys1234, Lys1248, Lys1251
  • Modification sites at PhosphoSitePlus

  • See CYFIP2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001032409.2  NP_001032410.1  NP_055191.2  

    ENSEMBL proteins: 
     ENSP00000429846   ENSP00000429135   ENSP00000428009   ENSP00000427933   ENSP00000428079  
     ENSP00000430904   ENSP00000430930   ENSP00000428520   ENSP00000428022   ENSP00000428645  
     ENSP00000428946   ENSP00000428156   ENSP00000428655   ENSP00000325817   ENSP00000313567  
     ENSP00000366799   ENSP00000444645   ENSP00000403793   ENSP00000390948  
    Reactome Protein details: Q96F07

    CYFIP2 Human Recombinant Protein Products:

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    Novus Biologicals CYFIP2 Proteins
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CYFIP2

     
    Search eBioscience for Proteins for CYFIP2 

    CYFIP2 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of CYFIP2
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    LSBio Antibodies in human, mouse, rat for CYFIP2

    CYFIP2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for CYFIP2
    Cloud-Clone Corp. CLIAs for CYFIP2
    Search eBioscience for ELISAs for CYFIP2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR008081 Cytoplasmic_FMR1-int
     IPR016536 Cytoplasmic_FMR1-int_sub

    Graphical View of Domain Structure for InterPro Entry Q96F07

    ProtoNet protein and cluster: Q96F07

    1 Blocks protein domain: IPB008081 Cytoplasmic fragile X mental retardation protein interacting protein signature

    UniProtKB/Swiss-Prot: CYFP2_HUMAN, Q96F07
    Similarity: Belongs to the CYFIP family


    Find genes that share domains with CYFIP2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CYFP2_HUMAN, Q96F07
    Function: Involved in T-cell adhesion and p53/TP53-dependent induction of apoptosis. Does not bind RNA
    Induction: By p53/TP53

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI11438699
    GO:0008009chemokine activity ----
         
    Find genes that share ontologies with CYFIP2           About GenesLikeMe


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Cyfip2):
     behavior/neurological  cardiovascular system  homeostasis/metabolism  mortality/aging  nervous system 

    Find genes that share phenotypes with CYFIP2           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CYFIP2
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CYFIP2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CYFIP2

    miRNA
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    miRTarBase miRNAs that target CYFIP2:
    hsa-mir-149-5p (MIRT045595), hsa-mir-423-3p (MIRT042505)

    Block miRNA regulation of human, mouse, rat CYFIP2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CYFIP2 (see all 36):
    hsa-miR-579 hsa-miR-4328 hsa-let-7a-2* hsa-miR-29b-1* hsa-miR-374c hsa-miR-3658 hsa-miR-30b* hsa-miR-30c-2*
    SwitchGear 3'UTR luciferase reporter plasmidCYFIP2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CYFIP2

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 3): CYFIP2 (NM_001037333)
    Browse Sino Biological Human cDNA Clones
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYFIP2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CYFP2_HUMAN, Q96F07: Cytoplasm. Cytoplasm, perinuclear region. Cell junction, synapse, synaptosome. Note=Highly
    expressed in the perinuclear region. Enriched in synaptosomes. Treatment with leptomycin-B triggers translocation
    to the nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus2
    cytoskeleton1
    lysosome1
    mitochondrion1
    vacuole1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----
    GO:0005737cytoplasm IDA11438699
    GO:0005829cytosol TAS--
    GO:0030054cell junction IEA--
    GO:0043005neuron projection IEA--

    Find genes that share ontologies with CYFIP2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CYFIP2 About   (see all 9)  
    See pathways by source

    SuperPathContained pathways About
    1Regulation of actin cytoskeleton
    Regulation of actin cytoskeleton0.57
    Regulation of Actin Cytoskeleton0.57
    2Fcgamma receptor (FCGR) dependent phagocytosis
    Regulation of actin dynamics for phagocytic cup formation0.77
    Fcgamma receptor (FCGR) dependent phagocytosis0.77
    3Apoptotic Pathways in Synovial Fibroblasts
    Rac1 Pathway0.65
    4G protein signaling RAC1 in cellular process
    G protein signaling RAC1 in cellular process0.37
    5CDC42 signaling events
    RAC1 signaling pathway0.34


    Find genes that share SuperPaths with CYFIP2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for CYFIP2
        Rac1 Pathway

    1 GeneGo (Thomson Reuters) Pathway for CYFIP2
        G-protein signaling RAC1 in cellular process

    5 BioSystems Pathways for CYFIP2
        Regulation of Actin Cytoskeleton
    E-cadherin signaling in the nascent adherens junction
    Stabilization and expansion of the E-cadherin adherens junction
    ErbB1 downstream signaling
    RAC1 signaling pathway

    1 Reactome Pathway for CYFIP2
        Regulation of actin dynamics for phagocytic cup formation


    2 Kegg Pathways  (Kegg details for CYFIP2):
        RNA transport
    Regulation of actin cytoskeleton

        Pathway & Disease-focused RT2 Profiler PCR Array including CYFIP2: 
              Cytoskeleton Regulators in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CYFIP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CYFIP2 (Q96F071, 2, 3 ENSP000003909484) via UniProtKB, MINT, STRING, and/or I2D (see all 61)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ABI1Q8IZP02, 3, ENSP000003653124MINT-45982 MINT-45988 I2D: score=4 STRING: ENSP00000365312
    FXR1P511142, 3, ENSP000003501704MINT-16283 I2D: score=5 STRING: ENSP00000350170
    GAS7O608612, 3, ENSP000003226084MINT-72914 I2D: score=4 STRING: ENSP00000322608
    FXR2P511162, 3, ENSP000002501134MINT-17596 I2D: score=3 STRING: ENSP00000250113
    ABI3Q9P2A42, 3, ENSP000002259414MINT-3390361 I2D: score=2 STRING: ENSP00000225941
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process IDA10449408
    GO:0006955immune response ----
    GO:0016337cell-cell adhesion IDA15048733
    GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis TAS--
    GO:0045087innate immune response TAS--

    Find genes that share ontologies with CYFIP2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CYFIP2 (CYFP2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CYFIP2 gene (3 alternative transcripts): 
    NM_001037332.2  NM_001037333.1  NM_014376.2  

    Unigene Cluster for CYFIP2:

    Cytoplasmic FMR1 interacting protein 2
    Hs.519702  [show with all ESTs]
    Unigene Representative Sequence: NM_001037332
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 31):
    ENST00000523969 ENST00000520759 ENST00000522463 ENST00000523119 ENST00000522637
    ENST00000521420 ENST00000519002 ENST00000519252 ENST00000520419 ENST00000522423
    ENST00000519153 ENST00000518456 ENST00000517850 ENST00000517753 ENST00000518511
    ENST00000520942 ENST00000520960 ENST00000518555
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate CYFIP2 (see all 36):
    hsa-miR-579 hsa-miR-4328 hsa-let-7a-2* hsa-miR-29b-1* hsa-miR-374c hsa-miR-3658 hsa-miR-30b* hsa-miR-30c-2*
    SwitchGear 3'UTR luciferase reporter plasmidCYFIP2 3' UTR sequence
    Inhib. RNA
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CYFIP2
      QuantiTect SYBR Green Assays in human, mouse, rat CYFIP2
      QuantiFast Probe-based Assays in human, mouse, rat CYFIP2

    Additional mRNA sequence: 

    AB032994.2 AF132197.1 AF160973.1 AK172724.1 AK223604.1 AK294220.1 AK295865.1 AK297401.1 
    AK303702.1 AK312157.1 AL136549.1 AL161999.1 BC011762.1 BC021008.1 BC026892.2 BC066933.1 
    L47738.1 

    24 DOTS entries:

    DT.91879845  DT.100655783  DT.454661  DT.444880  DT.100655781  DT.100862470  DT.95214650  DT.100738555 
    DT.101955204  DT.100655782  DT.120837307  DT.95262088  DT.95339040  DT.40252820  DT.416237  DT.100655785 
    DT.100803745  DT.120837343  DT.120837362  DT.120837395  DT.86838971  DT.97777401  DT.100722385  DT.97821880 

    Selected AceView cDNA sequences (see all 380):

    BX364037 AL713443 AW468488 AW576513 BM694352 AA682987 BU154305 AW574676 
    BU726545 AI422235 BQ049658 AA034345 AL547269 CA313478 NM_014376 BP361095 
    BM802687 AL136549 AA351287 BE048879 BE396592 BM691201 AW500843 BQ181756 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CYFIP2 (see all 16)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c · 11d ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^
    SP1:                                                  -                                                                                                         
    SP2:              -     -     -                       -                                                                                                     -   
    SP3:                                                  -                                                                                                     -   
    SP4:              -     -     -                       -                                   -                                                                     
    SP5:              -     -     -                 -     -     -     -                                                                                             

    ExUns: 20 ^ 21 ^ 22 ^ 23 ^ 24a · 24b · 24c ^ 25a · 25b ^ 26a · 26b ^ 27 ^ 28 ^ 29a · 29b ^ 30 ^ 31a · 31b ^ 32 ^ 33a · 33b · 33c ^ 34 ^ 35a · 35b · 35c ^
    SP1:        -                 -                                                                       -                 -           -     -           -     -   
    SP2:        -                 -                                                                       -                 -           -     -           -     -   
    SP3:        -                 -                                                                       -                 -           -     -           -     -   
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 36a · 36b ^ 37a · 37b · 37c
    SP1:                              
    SP2:                              
    SP3:                              
    SP4:                              
    SP5:                              


    ECgene alternative splicing isoforms for CYFIP2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    CYFIP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGGTTTCTC
    CYFIP2 Expression
    About this image


    CYFIP2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 13) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Telencephalon
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Prechondrocytic Mesenchymal Cells Zeugopod
             Stylopod Long Bone
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             GABAergic Amacrine Cells Inner Nuclear Layer
     
     Neurons
             GABAergic Amacrine Cells Inner Nuclear Layer
     
     Cartilage (Muscoskeletal System)
             Prechondrocytic Mesenchymal Cells Zeugopod
    CYFIP2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CYFIP2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.519702

    UniProtKB/Swiss-Prot: CYFP2_HUMAN, Q96F07
    Tissue specificity: Expressed in T-cells. Increased expression is observed in CD4(+) T-lymphocytes from patients
    with multiple sclerosis (at protein level)

        Pathway & Disease-focused RT2 Profiler PCR Array including CYFIP2: 
              Cytoskeleton Regulators in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CYFIP2 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cyfip21 , 5 cytoplasmic FMR1 interacting protein 21, 5 90.9(n)1
    99.92(a)1
      11 (27.61 cM)5
    768841  NM_001252459.11  NP_001239388.11 
     461938555 
    chicken
    (Gallus gallus)
    Aves CYFIP21 cytoplasmic FMR1 interacting protein 2 86.19(n)
    99.84(a)
      416246  XM_004944914.1  XP_004944971.1 
    lizard
    (Anolis carolinensis)
    Reptilia CYFIP26
    cytoplasmic FMR1 interacting protein 2
    98(a)
    1 ↔ 1
    GL343205.1(2626804-2701859)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.118842 Xenopus laevis transcribed sequence with strong similarity more 82.72(n)    BJ060443.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cyfip21 cytoplasmic FMR1 interacting protein 2 83.55(n)
    98.24(a)
      100002872  NM_001097587.1  NP_001091056.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Sra-11 , 3 Rho interactor3
    specifically Rac1-associated protein 11
    65(a)3
    65.86(n)1
    67.76(a)1
      88F13
    418611  NM_142190.31  NP_650447.11 
    worm
    (Caenorhabditis elegans)
    Secernentea gex-26
    Protein GEX-2 (gex-2) mRNA, complete cds
    49(a)
    1 → many
    IV(572723-583601) WBGene00001579
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons PIR1211 PIR121 44.31(n)
    31.6(a)
      831959  NM_121846.4  NP_197342.3 


    ENSEMBL Gene Tree for CYFIP2 (if available)
    TreeFam Gene Tree for CYFIP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CYFIP2 gene
    CYFIP12  
    2 SIMAP similar genes for CYFIP2 using alignment to 11 protein entries:     CYFP2_HUMAN (see all proteins):
    DKFZp761H087    CYFIP1

    Find genes that share paralogs with CYFIP2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CYFIP2 (see all 2685)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1142387181,2
    C,F--156691381(+) TCACAC/TTGAAC 2 -- us2k11Minor allele frequency- T:0.03NA 120
    rs2002424691,2
    --156691401(+) ATGTA-/TGTGTGT 2 -- us2k10--------
    rs1434812261,2
    C--156691409(+) ATATA-/TAAGTCA 2 -- us2k10--------
    rs361154461,2
    C--156691410(+) TGTGT-/TA    
       
    /TATA
    ATATA
    2 -- us2k10--------
    rs1890583571,2
    C--156691411(+) TGTGTA/GTATAT 2 -- us2k10--------
    rs733021381,2
    C,F--156691442(+) TTTCCG/AAAATA 2 -- us2k12Minor allele frequency- A:0.03WA 120
    rs1435773201,2
    --156691542(+) GAAAGC/GAAAGG 2 -- us2k10--------
    rs1811500511,2
    --156691627(+) GATTAA/CGTATA 2 -- us2k10--------
    rs1840551451,2
    --156691819(+) TTTGGG/TGCAGC 2 -- us2k10--------
    rs1880468441,2
    --156691887(+) TTCTCC/TTTTTC 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for CYFIP2 (156693089 - 156822606 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CYFIP2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv830526CNV Loss17160897
    nsv515686CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CYFIP2
    DNA2.0 Custom Variant and Variant Library Synthesis for CYFIP2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606323    OMIM disorders: --


    Find genes that share disorders with CYFIP2           About GenesLikeMe

    Genetic Association Database (GAD): CYFIP2
    Human Genome Epidemiology (HuGE) Navigator: CYFIP2 (3 documents)

    Export disorders for CYFIP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CYFIP2 gene, integrated from 10 sources (see all 48):
    (articles sorted by number of sources associating them with CYFIP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. CYFIP2 is highly abundant in CD4+ cells from multiple sclerosis patients and is involved in T cell adhesion. (PubMed id 15048733)1, 2, 9 Mayne M.... Melanson M. (Eur. J. Immunol. 2004)
    2. Evaluation of candidate genes in a genome-wide association study of childhood asthma in Mexicans. (PubMed id 19910030)1, 4, 9 Wu H....London S.J. (J. Allergy Clin. Immunol. 2010)
    3. Analyses of associations between three positionally cloned asthma candidate genes and asthma or asthma-related phenotypes in a Chinese population. (PubMed id 19951440)1, 4 Zhou H....Xu X. (BMC Med. Genet. 2009)
    4. Analyses of associations with asthma in four asthma population samples from Canada and Australia. (PubMed id 19247692)1, 4 Daley D....Hudson T.J. (Hum. Genet. 2009)
    5. CYFIP2, a direct p53 target, is leptomycin-B sensitive. (PubMed id 17245118)1, 2 Jackson R.S. II... Liang P. (Cell Cycle 2007)
    6. Evolutionarily conserved human targets of adenosine to inosine RNA editing. (PubMed id 15731336)1, 2 Levanon E.Y.... Eisenberg E. (Nucleic Acids Res. 2005)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (Genome Res. 2001)
    9. A highly conserved protein family interacting with the fragile X mental retardation protein (FMRP) and displaying selective interactions with FMRP-related proteins FXR1P and FXR2P. (PubMed id 11438699)1, 3 Schenck A....Mandel J.L. (Proc. Natl. Acad. Sci. U.S.A. 2001)
    10. Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PubMed id 10574461)1, 2 Hirosawa M.... Ohara O. (DNA Res. 1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 26999 HGNC: 13760 AceView: CYFIP2 Ensembl:ENSG00000055163 euGenes: HUgn26999
    ECgene: CYFIP2 Kegg: 26999 H-InvDB: CYFIP2

    (According to HUGE)
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    HUGE: KIAA1168

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CYFIP2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CYFIP2 gene:
    Search GeneIP for patents involving CYFIP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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