Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CYFIP2 Gene

Aliases for CYFIP2 Gene

  • Cytoplasmic FMR1 Interacting Protein 2 2 3 5
  • P53-Inducible Protein 121 3 4
  • PIR121 3 4
  • P53 Inducible Protein 2
  • KIAA1168 4

External Ids for CYFIP2 Gene

Previous GeneCards Identifiers for CYFIP2 Gene

  • GC05P156742
  • GC05P156628
  • GC05P156673
  • GC05P156674
  • GC05P151780

Summaries for CYFIP2 Gene

GeneCards Summary for CYFIP2 Gene

CYFIP2 (Cytoplasmic FMR1 Interacting Protein 2) is a Protein Coding gene. Diseases associated with CYFIP2 include fragile x syndrome and amyotrophic lateral sclerosis 1. Among its related pathways are Signaling by GPCR and Signaling by Rho GTPases. GO annotations related to this gene include chemokine activity. An important paralog of this gene is CYFIP1.

UniProtKB/Swiss-Prot for CYFIP2 Gene

  • Involved in T-cell adhesion and p53/TP53-dependent induction of apoptosis. Does not bind RNA.

Gene Wiki entry for CYFIP2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYFIP2 Gene

Genomics for CYFIP2 Gene

Regulatory Elements for CYFIP2 Gene

Promoters for CYFIP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CYFIP2 on UCSC Golden Path with GeneCards custom track

Genomic Location for CYFIP2 Gene

Chromosome:
5
Start:
157,266,079 bp from pter
End:
157,395,598 bp from pter
Size:
129,520 bases
Orientation:
Plus strand

Genomic View for CYFIP2 Gene

Genes around CYFIP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CYFIP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CYFIP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYFIP2 Gene

Proteins for CYFIP2 Gene

  • Protein details for CYFIP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96F07-CYFP2_HUMAN
    Recommended name:
    Cytoplasmic FMR1-interacting protein 2
    Protein Accession:
    Q96F07
    Secondary Accessions:
    • A6NLT2
    • D3DQJ3
    • Q53EN5
    • Q9NTK4
    • Q9ULQ2
    • Q9UN29

    Protein attributes for CYFIP2 Gene

    Size:
    1278 amino acids
    Molecular mass:
    148399 Da
    Quaternary structure:
    • Interacts with FMR1, FXR1 AND FXR2. Component of the WAVE1 complex composed of ABI2, CYFIP2, BRK1, NCKAP1 and WASF1/WAVE1. CYFIP2 binds to activated RAC1 which causes the complex to dissociate, releasing activated WASF1. The complex can also be activated by NCK1. Interacts with SHANK3; the interaction mediates the association of SHANK3 with the WAVE1 complex.
    SequenceCaution:
    • Sequence=BAA86482.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAD97324.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for CYFIP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CYFIP2 Gene

Proteomics data for CYFIP2 Gene at MOPED

Post-translational modifications for CYFIP2 Gene

  • Ubiquitination at Lys 197, Lys 300, Lys 545, Lys 775, Lys 903, Lys 916, Lys 1077, Lys 1234, Lys 1248, and Lys 1251
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CYFIP2 Gene

Domains & Families for CYFIP2 Gene

Suggested Antigen Peptide Sequences for CYFIP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96F07

UniProtKB/Swiss-Prot:

CYFP2_HUMAN :
  • Belongs to the CYFIP family.
Family:
  • Belongs to the CYFIP family.
genes like me logo Genes that share domains with CYFIP2: view

No data available for Gene Families for CYFIP2 Gene

Function for CYFIP2 Gene

Molecular function for CYFIP2 Gene

UniProtKB/Swiss-Prot Function:
Involved in T-cell adhesion and p53/TP53-dependent induction of apoptosis. Does not bind RNA.
UniProtKB/Swiss-Prot Induction:
By p53/TP53.
genes like me logo Genes that share phenotypes with CYFIP2: view

Animal Models for CYFIP2 Gene

MGI Knock Outs for CYFIP2:

Animal Model Products

miRNA for CYFIP2 Gene

miRTarBase miRNAs that target CYFIP2

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CYFIP2 Gene

Localization for CYFIP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYFIP2 Gene

Cytoplasm. Nucleus. Cytoplasm, perinuclear region. Cell junction, synapse, synaptosome. Note=Highly expressed in the perinuclear regionand enriched in synaptosomes (By similarity). Treatment with leptomycin-B triggers translocation to the nucleus (PubMed:17245118). {ECO:0000250 UniProtKB:Q5SQX6, ECO:0000269 PubMed:17245118}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CYFIP2 Gene COMPARTMENTS Subcellular localization image for CYFIP2 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 4
cytoskeleton 2
mitochondrion 2

Gene Ontology (GO) - Cellular Components for CYFIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 11438699
GO:0030054 cell junction IEA --
GO:0048471 perinuclear region of cytoplasm IDA 10449408
genes like me logo Genes that share ontologies with CYFIP2: view

Pathways & Interactions for CYFIP2 Gene

genes like me logo Genes that share pathways with CYFIP2: view

Gene Ontology (GO) - Biological Process for CYFIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IDA 10449408
GO:0016337 single organismal cell-cell adhesion IDA 15048733
GO:0045087 innate immune response TAS --
GO:0097202 activation of cysteine-type endopeptidase activity IDA 18387192
genes like me logo Genes that share ontologies with CYFIP2: view

No data available for SIGNOR curated interactions for CYFIP2 Gene

Drugs & Compounds for CYFIP2 Gene

No Compound Related Data Available

Transcripts for CYFIP2 Gene

Unigene Clusters for CYFIP2 Gene

Cytoplasmic FMR1 interacting protein 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CYFIP2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c · 11d ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^
SP1: -
SP2: - - - - -
SP3: - -
SP4: - - - - -
SP5: - - - - - - -
SP6:
SP7: - -
SP8:
SP9:
SP10:
SP11:
SP12:
SP13: - -
SP14:
SP15:
SP16:

ExUns: 20 ^ 21 ^ 22 ^ 23 ^ 24a · 24b · 24c ^ 25a · 25b ^ 26a · 26b ^ 27 ^ 28 ^ 29a · 29b ^ 30 ^ 31a · 31b ^ 32 ^ 33a · 33b · 33c ^ 34 ^ 35a · 35b · 35c ^
SP1: - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - - -
SP4:
SP5:
SP6:
SP7:
SP8: - -
SP9: -
SP10: - - - -
SP11:
SP12: - -
SP13:
SP14: -
SP15: - -
SP16:

ExUns: 36a · 36b ^ 37a · 37b · 37c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:

Relevant External Links for CYFIP2 Gene

GeneLoc Exon Structure for
CYFIP2
ECgene alternative splicing isoforms for
CYFIP2

Expression for CYFIP2 Gene

mRNA expression in normal human tissues for CYFIP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CYFIP2 Gene

This gene is overexpressed in Whole Blood (x4.7).

Protein differential expression in normal tissues from HIPED for CYFIP2 Gene

This gene is overexpressed in Frontal cortex (14.7), Lymph node (12.6), Brain (10.0), and Fetal Brain (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for CYFIP2 Gene



SOURCE GeneReport for Unigene cluster for CYFIP2 Gene Hs.519702

mRNA Expression by UniProt/SwissProt for CYFIP2 Gene

Q96F07-CYFP2_HUMAN
Tissue specificity: Expressed in T-cells. Increased expression is observed in CD4(+) T-lymphocytes from patients with multiple sclerosis (at protein level).
genes like me logo Genes that share expression patterns with CYFIP2: view

Protein tissue co-expression partners for CYFIP2 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for CYFIP2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CYFIP2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CYFIP2 35
  • 92.36 (n)
  • 99.84 (a)
CYFIP2 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CYFIP2 35
  • 93.03 (n)
  • 99.92 (a)
CYFIP2 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cyfip2 35
  • 90.9 (n)
  • 99.92 (a)
Cyfip2 16
Cyfip2 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CYFIP2 35
  • 99.65 (n)
  • 100 (a)
CYFIP2 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CYFIP2 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CYFIP2 36
  • 95 (a)
OneToOne
chicken
(Gallus gallus)
Aves CYFIP2 35
  • 86.19 (n)
  • 99.84 (a)
CYFIP2 36
  • 98 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CYFIP2 36
  • 98 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cyfip2 35
  • 82.97 (n)
  • 98.32 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.11884 35
zebrafish
(Danio rerio)
Actinopterygii cyfip2 35
  • 83.55 (n)
  • 98.24 (a)
cyfip2 36
  • 96 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Sra-1 37
  • 65 (a)
Sra-1 35
  • 65.86 (n)
  • 67.76 (a)
Sra-1 36
  • 64 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000195 35
  • 66.29 (n)
  • 67.82 (a)
worm
(Caenorhabditis elegans)
Secernentea gex-2 36
  • 49 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons PIR121 35
  • 44.31 (n)
  • 31.6 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3302 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 64 (a)
OneToMany
Species with no ortholog for CYFIP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CYFIP2 Gene

ENSEMBL:
Gene Tree for CYFIP2 (if available)
TreeFam:
Gene Tree for CYFIP2 (if available)

Paralogs for CYFIP2 Gene

Paralogs for CYFIP2 Gene

genes like me logo Genes that share paralogs with CYFIP2: view

Variants for CYFIP2 Gene

Sequence variations from dbSNP and Humsavar for CYFIP2 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs3207362 - 157,309,800(+) ACATT(A/G/T)AGACC reference, missense
rs1247 -- 157,334,597(-) caata(A/G)tatgt intron-variant
rs1248 -- 157,334,609(-) aTATG(A/T)tgata intron-variant
rs1249 -- 157,334,582(-) ctggt(A/G)atatt intron-variant
rs187458 -- 157,266,552(+) GGCCG(C/G)GAGCC intron-variant, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for CYFIP2 Gene

Variant ID Type Subtype PubMed ID
nsv515686 CNV Loss 19592680
nsv830526 CNV Loss 17160897

Variation tolerance for CYFIP2 Gene

Gene Damage Index Score: 1.55; 29.98% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CYFIP2 Gene

HapMap Linkage Disequilibrium report
CYFIP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CYFIP2 Gene

Disorders for CYFIP2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for CYFIP2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
fragile x syndrome
  • fragile x mental retardation syndrome
amyotrophic lateral sclerosis 1
  • amyotrophic lateral sclerosis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CYFIP2

Genetic Association Database (GAD)
CYFIP2
Human Genome Epidemiology (HuGE) Navigator
CYFIP2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CYFIP2
genes like me logo Genes that share disorders with CYFIP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CYFIP2 Gene

Publications for CYFIP2 Gene

  1. CYFIP2 is highly abundant in CD4+ cells from multiple sclerosis patients and is involved in T cell adhesion. (PMID: 15048733) Mayne M. … Melanson M. (Eur. J. Immunol. 2004) 3 4 23 67
  2. Evaluation of candidate genes in a genome-wide association study of childhood asthma in Mexicans. (PMID: 19910030) Wu H. … London S.J. (J. Allergy Clin. Immunol. 2010) 3 23
  3. A highly conserved protein family interacting with the fragile X mental retardation protein (FMRP) and displaying selective interactions with FMRP-related proteins FXR1P and FXR2P. (PMID: 11438699) Schenck A. … Mandel J.L. (Proc. Natl. Acad. Sci. U.S.A. 2001) 2 3
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for CYFIP2 Gene

Sources for CYFIP2 Gene

Back to Top

Content