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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CYFIP2 Gene

protein-coding GIFtS: 63
GCID: GC05P156674

cytoplasmic FMR1 interacting protein 2

Explore 3 diseases affiliated with
CYFIP2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Cytoplasmic FMR1 Interacting Protein 2¹ ²
PIR121¹ ² ³
P53-Inducible Protein 121² ³
Cytoplasmic FMR1-Interacting Protein 2²
P53 Inducible Protein²
KIAA1168³

External Ids:	HGNC: 13760¹	Entrez Gene: 26999²	Ensembl: ENSG00000055163⁷	OMIM: 606323⁵	UniProtKB: Q96F07³

Export aliases for CYFIP2 gene to outside databases

Previous GC identifers: GC05P156742 GC05P157244 GC05P156628 GC05P156673 GC05P151780

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: CYFP2_HUMAN, Q96F07

Function: Involved in T-cell adhesion and p53/TP53-dependent induction of apoptosis. Does not bind RNA

Gene Wiki entry for CYFIP2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000005.9 NC_018916.1 NT_023133.13

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CYFIP2 gene promoter:
SRY Elk-1 POU6F1 (c2) MRF-2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CYFIP2 promoter sequence

Search SABiosciences Chromatin IP Primers for CYFIP2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CYFIP2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q33.3 Ensembl cytogenetic band: 5q33.3 HGNC cytogenetic band: 5q34

CYFIP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CYFIP2 gene location

GeneLoc information about chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05P156674: view genomic region (about GC identifiers)

Start:	156,693,089 bp from pter	End:	156,822,606 bp from pter
Size:	129,518 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CYFP2_HUMAN, Q96F07 (See protein sequence)

Recommended Name: Cytoplasmic FMR1-interacting protein 2

Size: 1278 amino acids; 148399 Da

Subunit: Interacts with FMR1, FXR1 AND FXR2. Component of the WAVE1 complex composed of ABI2, CYFIP2, BRK1, NCKAP1 and

WASF1/WAVE1. CYFIP2 binds to activated RAC1 which causes the complex to dissociate, releasing activated WASF1. The

complex can also be activated by NCK1

Subcellular location: Cytoplasm. Cytoplasm, perinuclear region. Cell junction, synapse, synaptosome. Note=Highly

expressed in the perinuclear region. Enriched in synaptosomes. Treatment with leptomycin-B triggers translocation to

the nucleus

Rna editing: Modified_positions=320; Note=Partially edited. Editing appears to be brain-specific

Sequence caution: Sequence=BAA86482.2; Type=Erroneous initiation; Sequence=BAD97324.1; Type=Erroneous initiation;

Secondary accessions: A6NLT2 D3DQJ3 Q53EN5 Q9NTK4 Q9ULQ2 Q9UN29

Alternative splicing: 2 isoforms: Q96F07-1 Q96F07-2

Explore the universe of human proteins at neXtProt for CYFIP2: NX_Q96F07

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q96F07

CYFIP2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001032409.2 NP_001032410.1 NP_055191.2

ENSEMBL proteins:

ENSP00000429846 ENSP00000429135 ENSP00000428009 ENSP00000427933 ENSP00000428079

ENSP00000430904 ENSP00000430930 ENSP00000428520 ENSP00000428022 ENSP00000428645

ENSP00000428946 ENSP00000428156 ENSP00000428655 ENSP00000325817 ENSP00000313567

ENSP00000366799 ENSP00000444645 ENSP00000403793 ENSP00000390948

Reactome Protein details: Q96F07
Human Recombinant Protein Products for CYFIP2:

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	Novus Biologicals CYFIP2 Proteins
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for CYFIP2

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IDA	11438699
GO:0019717	synaptosome	--	--
GO:0030054	cell junction	IEA	--
GO:0043005	neuron projection	IEA	--
GO:0045202	synapse	IDA	11438699

CYFIP2 for ontologies About GeneDecksing

CYFIP2 Antibody Products:

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	ThermoFisher Antibody for CYFIP2

Assay Products for CYFIP2:

	Browse Kits and Assays available from EMD Millipore
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	Uscn ELISAs and CLIAs for CYFIP2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CYFIP2 for domains About GeneDecksing

2 InterPro domains/families:

IPR008081 Cytoplasmic_FMR1-int

IPR016536 Cytoplasmic_FMR1-int_sub

Graphical View of Domain Structure for InterPro Entry Q96F07

ProtoNet protein and cluster: Q96F07

1 Blocks protein family: IPB008081 Cytoplasmic fragile X mental retardation protein interacting protein signature

UniProtKB/Swiss-Prot: CYFP2_HUMAN, Q96F07

Similarity: Belongs to the CYFIP family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: CYFP2_HUMAN, Q96F07

Function: Involved in T-cell adhesion and p53/TP53-dependent induction of apoptosis. Does not bind RNA

Induction: By p53/TP53

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	11438699

CYFIP2 for ontologies About GeneDecksing

Phenotypes:
1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Cyfip2):

mortality/aging

CYFIP2 for phenotypes About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for CYFIP2

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CYFIP2
		8/36 QIAGEN miScript miRNA Assays for microRNAs that regulate CYFIP2 (see all 36):
		hsa-miR-579 hsa-miR-4328 hsa-let-7a-2* hsa-miR-29b-1* hsa-miR-374c hsa-miR-3658 hsa-miR-30b* hsa-miR-30c-2*

		SwitchGear 3'UTR luciferase reporter plasmid: CYFIP2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYFIP2

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Regulation of actin dynamics for phagocytic cup formation

	Regulation of actin dynamics for phagocytic cup formation	1.00			Fcgamma receptor (FCGR) dependent phagocytosis	0.80
	Role of myosins in phagosome formation	0.80			Branching and elongation of mother and daughter filaments	0.29

G-protein signaling_RAC1 in cellular process

	G-protein signaling RAC1 in cellular process	1.00			RAC1 signaling pathway	0.34
	G-protein signaling_RAC1 in cellular process	1.00

Immune System

Immune System

1.00

Innate Immune System

0.46

Regulation of Actin Cytoskeleton

Regulation of Actin Cytoskeleton

1.00

Regulation of actin cytoskeleton

0.58

ErbB1 downstream signaling

ErbB1 downstream signaling

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for CYFIP2

G-protein signaling RAC1 in cellular process

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for CYFIP2

Rac1 Pathway

1 GeneGo (Thomson Reuters) Pathway for CYFIP2

G-protein signaling RAC1 in cellular process

5 BioSystems Pathways for CYFIP2

	Regulation of Actin Cytoskeleton
	ErbB1 downstream signaling
	RAC1 signaling pathway
	E-cadherin signaling in the nascent adherens junction
	Stabilization and expansion of the E-cadherin adherens junction

5/6 Reactome Pathways for CYFIP2 (see all 6)

	Role of myosins in phagosome formation
	Branching and elongation of mother and daughter filaments
	Regulation of actin dynamics for phagocytic cup formation
	Fcgamma receptor (FCGR) dependent phagocytosis
	Immune System

1 Kegg Pathway (Kegg details for CYFIP2):

Regulation of actin cytoskeleton

CYFIP2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CYFIP2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/51 Interacting proteins for CYFIP2 (Q96F07^{1, 2, 3} ENSP00000390948⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 51)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ABI1	Q8IZP0²^,³, ENSP00000365312⁴	MINT-45982 MINT-45988 I2D: score=4 STRING: ENSP00000365312
FXR1	P51114²^,³, ENSP00000350170⁴	MINT-16283 I2D: score=5 STRING: ENSP00000350170
GAS7	O60861²^,³, ENSP00000322608⁴	MINT-72914 I2D: score=4 STRING: ENSP00000322608
FXR2	P51116²^,³, ENSP00000250113⁴	MINT-17596 I2D: score=3 STRING: ENSP00000250113
ABI3	Q9P2A4²^,³, ENSP00000225941⁴	MINT-3390361 I2D: score=2 STRING: ENSP00000225941

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006915	apoptotic process	IDA	10449408
GO:0016337	cell-cell adhesion	IDA	15048733

CYFIP2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CYFIP2
Search CenterWatch for drugs/clinical trials and news about CYFIP2 / CYFP2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CYFIP2 gene (3 alternative transcripts):

NM_001037332.2 NM_001037333.1 NM_014376.2

Unigene Cluster for CYFIP2:

Cytoplasmic FMR1 interacting protein 2

Hs.519702 [show with all ESTs]

Unigene Representative Sequence: NM_001037332

18/31 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 31):

ENST00000523969 ENST00000520759 ENST00000522463 ENST00000523119 ENST00000522637

ENST00000521420 ENST00000519002 ENST00000519252 ENST00000520419 ENST00000522423

ENST00000519153 ENST00000518456 ENST00000517850 ENST00000517753 ENST00000518511

ENST00000520942 ENST00000520960 ENST00000518555

miRNA Products:		OriGene 3'-UTR Clone (see all 3): CYFIP2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CYFIP2
		8/36 QIAGEN miScript miRNA Assays for microRNAs that regulate CYFIP2 (see all 36):
		hsa-miR-579 hsa-miR-4328 hsa-let-7a-2* hsa-miR-29b-1* hsa-miR-374c hsa-miR-3658 hsa-miR-30b* hsa-miR-30c-2*

		SwitchGear 3'UTR luciferase reporter plasmid: CYFIP2 3' UTR sequence

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Additional cDNA sequence:

AB032994.2 AF132197.1 AF160973.1 AK172724.1 AK223604.1 AK294220.1 AK295865.1 AK297401.1

AK303702.1 AK312157.1 AL136549.1 AL161999.1 BC011762.1 BC021008.1 BC026892.2 BC066933.1

L47738.1

24 DOTS entries:

DT.91879845 DT.100655783 DT.454661 DT.444880 DT.100655781 DT.100862470 DT.95214650 DT.100738555

DT.101955204 DT.100655782 DT.120837307 DT.95262088 DT.95339040 DT.40252820 DT.416237 DT.100655785

DT.100803745 DT.120837343 DT.120837362 DT.120837395 DT.86838971 DT.97777401 DT.100722385 DT.97821880

24/380 AceView cDNA sequences (see all 380):

BP361095 BP350074 AI433299 BM457177 BU175638 R54588 AW500843 BQ216347

AA682987 AA034345 BQ049658 BM691201 BC021008 AI954773 BE501906 CF143725

BU844979 BE396592 BQ721622 BM460242 BP368520 AA309733 BE551722 AW499580

GeneLoc Exon Structure

5/16 Alternative Splicing Database (ASD) splice patterns (SP) for CYFIP2 (see all 16) About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4	^	5a	·	5b	^	6	^	7	^	8	^	9a	·	9b	^	10	^	11a	·	11b	·	11c	·	11d	^	12	^	13	^	14	^	15	^	16	^	17	^	18	^	19	^
SP1:																	-
SP2:					-		-		-								-																																		-
SP3:																	-																																		-
SP4:					-		-		-								-												-
SP5:					-		-		-						-		-		-		-

ExUns:	20	^	21	^	22	^	23	^	24a	·	24b	·	24c	^	25a	·	25b	^	26a	·	26b	^	27	^	28	^	29a	·	29b	^	30	^	31a	·	31b	^	32	^	33a	·	33b	·	33c	^	34	^	35a	·	35b	·	35c	^
SP1:			-						-																								-						-				-		-				-		-
SP2:			-						-																								-						-				-		-				-		-
SP3:			-						-																								-						-				-		-				-		-
SP4:
SP5:

ExUns:	36a	·	36b	^	37a	·	37b	·	37c
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for CYFIP2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CYFIP2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTGGTTTCTC

About this image

CYFIP2 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

3 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Testis

Seminiferous Tubules

Sertoli cells

Testis

Bone

Skeletal Muscle

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 7 LifeMap Cells

Name

Category

PureStem™ endothelial progenitor 30-SM2-1 (Embryonic Progenitor Cell)

Endothelium

PureStem™ progenitor E68 (Embryonic Progenitor Cell)

PureStem™ epithelial progenitor E164 (Embryonic Progenitor Cell)

Intermediate Mesoderm, Kidney

PureStem™ mesenchymal progenitor E15 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ progenitor E69 (Embryonic Progenitor Cell)

PureStem™ progenitor SM22 (Embryonic Progenitor Cell)

PureStem™ progenitor U31 (Embryonic Progenitor Cell)

See CYFIP2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CYFIP2

SOURCE GeneReport for Unigene cluster: Hs.519702

UniProtKB/Swiss-Prot: CYFP2_HUMAN, Q96F07

Tissue specificity: Expressed in T-cells. Increased expression is observed in CD4(+) T-lymphocytes from patients with

multiple sclerosis (at protein level)

SABiosciences Expression via Pathway-Focused PCR Array including CYFIP2:

Cytoskeleton Regulators in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYFIP2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for CYFIP2 gene from 9/25 species (see all 25) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Cyfip2^{1 , 5}	cytoplasmic FMR1 interacting protein 2^{1, 5}	90.9(n)¹ 99.92(a)¹		11 (27.61 cM)⁵ 76884¹ NM_001252459.1¹ NP_001239388.1¹ 46193855⁵
chicken (Gallus gallus)	Aves	CYFIP2¹	cytoplasmic FMR1 interacting protein 2	86.19(n) 99.84(a)		416246 XM_414567.3 XP_414567.2
lizard (Anolis carolinensis)	Reptilia	CYFIP2⁶	--	98(a)	1 ↔ 1	GL343205.1(2643426-2699568)
African clawed frog (Xenopus laevis)	Amphibia	Xl.11884²	Xenopus laevis transcribed sequence with strong similarity more	82.72(n)		BJ060443.1
zebrafish (Danio rerio)	Actinopterygii	cyfip2¹	cytoplasmic FMR1 interacting protein 2	83.55(n) 98.24(a)		100002872 NM_001097587.1 NP_001091056.1
fruit fly (Drosophila melanogaster)	Insecta	Sra-1^{1 , 3}	Rho interactor³ specifically Rac1-associated protein 1¹	65(a)³ 65.86(n)¹ 67.76(a)¹		88F1³ 41861¹ NM_142190.2¹ NP_650447.1¹
worm (Caenorhabditis elegans)	Secernentea	gex-2⁶	Cytoplasmic FMR1-interacting protein homolog	50(a)	1 → many	IV(572723-583601)
thale cress (Arabidopsis thaliana)	eudicotyledons	PIR121¹	protein PIR	44.29(n) 31.01(a)		831959 NM_121846.4 NP_197342.3
rice (Oryza sativa)	Liliopsida	--	PIR, putative, expressed	27(a)	1 → many	3(2431918-2448211)

ENSEMBL Gene Tree for CYFIP2 (if available)
TreeFam Gene Tree for CYFIP2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for CYFIP2 gene

CYFIP1²

2 SIMAP similar genes for CYFIP2 using alignment to 11 protein entries: CYFP2_HUMAN (see all proteins):

DKFZp761H087 CYFIP1

CYFIP2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 5 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs114238718^1,2	C,F	--	156691381(+)	`TCACAC/TTGAAC`	2	--	us2k¹		1		NA	120
rs200242469^1,2		--	156691401(+)	`ATGTA-/TGTGTGT`	2	--	us2k¹		0	--	--	--	--
rs143481226^1,2	C	--	156691409(+)	`GTGTG-/TATATAT`	2	--	us2k¹		0	--	--	--	--
rs189058357^1,2	C	--	156691411(+)	`TGTGTA/GTATAT`	2	--	us2k¹		0	--	--	--	--
rs73302138^1,2	C	--	156691442(+)	`TTTCCG/AAAATA`	2	--	us2k¹		2		WA	120
rs143577320^1,2		--	156691542(+)	`GAAAGC/GAAAGG`	2	--	us2k¹		0	--	--	--	--
rs181150051^1,2		--	156691627(+)	`GATTAA/CGTATA`	2	--	us2k¹		0	--	--	--	--
rs184055145^1,2		--	156691819(+)	`TTTGGG/TGCAGC`	2	--	us2k¹		0	--	--	--	--
rs188046844^1,2		--	156691887(+)	`TTCTCC/TTTTTC`	2	--	us2k¹		0	--	--	--	--
rs72545377^1,2	C	--	156691938(+)	`CTCTCTT/-TCTTT`	2	--	us2k¹		1		CSA	2

HapMap Linkage Disequilibrium report for CYFIP2 (156693089 - 156822606 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for CYFIP2
1 CNV: 51598

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CYFIP2 for disorders           About GeneDecksing

OMIM gene information: 606323    OMIM disorders: --

3 diseases for CYFIP2:    About MalaCards

multiple sclerosis gout asthma

Human Genome Epidemiology (HuGE) Navigator: CYFIP2 (3 documents)

Export disorders for CYFIP2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for CYFIP2 gene, integrated from 9 sources (see all 40):
(articles sorted by number of sources associating them with CYFIP2)

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world of online information

CYFIP2 is highly abundant in CD4+ cells from multiple sclerosis patients and is involved in T cell adhesion. (PubMed id 15048733)^{1, 2, 9} Mayne M.... Melanson M. (2004)
CYFIP2, a direct p53 target, is leptomycin-B sensitive. (PubMed id 17245118)^{1, 2} Jackson R.S. II... Liang P. (2007)
Evolutionarily conserved human targets of adenosine to inosine RNA editing. (PubMed id 15731336)^{1, 2} Levanon E.Y.... Eisenberg E. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)^{1, 2} Wiemann S.... Poustka A. (2001)
A highly conserved protein family interacting with the fragile X mental retardation protein (FMRP) and displaying selective interactions with FMRP-related proteins FXR1P and FXR2P. (PubMed id 11438699)^{1, 3} Schenck A....Mandel J.L. (2001)
Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PubMed id 10574461)^{1, 2} Hirosawa M.... Ohara O. (1999)
Increased apoptosis induction by 121F mutant p53. (PubMed id 10449408)^{1, 2} Saller E....Iggo R. (1999)
Evaluation of candidate genes in a genome-wide associ ation study of childhood asthma in Mexicans. (PubMed id 19910030)^{1, 9} Wu H....London S.J. (2010)
Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)¹ Udeshi N.D....Carr S.A. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 26999	HGNC: 13760	AceView: CYFIP2	Ensembl:ENSG00000055163	euGenes: HUgn26999
ECgene: CYFIP2	Kegg: 26999	H-InvDB: CYFIP2

(According to HUGE)
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HUGE: KIAA1168

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CYFIP2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for CYFIP2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for CYFIP2 gene:
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GeneCards and IP:
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CYFIP2 Gene

cytoplasmic FMR1 interacting protein 2

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CYFIP2 Gene

cytoplasmic FMR1 interacting protein 2

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