Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CYFIP1 Gene

Aliases for CYFIP1 Gene

  • Cytoplasmic FMR1 Interacting Protein 1 2 3
  • Cytoplasmic FMRP Interacting Protein 1 2 3
  • Specifically Rac1-Associated Protein 1 3 4
  • Selective Hybridizing Clone 2 3
  • P140SRA-1 3 4
  • KIAA0068 4 6
  • SRA-1 3 4
  • Cytoplasmic FMR1-Interacting Protein 1 3
  • SRA1 3
  • SHYC 3

External Ids for CYFIP1 Gene

Previous GeneCards Identifiers for CYFIP1 Gene

  • GC15P019172
  • GC15M015990
  • GC15P020311
  • GC15P020440
  • GC15P020444
  • GC15P023697
  • GC15P023717
  • GC15P001205
  • GC15P023748
  • GC15P023761
  • GC15P023780
  • GC15P023809
  • GC15P023843
  • GC15P023873
  • GC15P023905

Summaries for CYFIP1 Gene

GeneCards Summary for CYFIP1 Gene

CYFIP1 (Cytoplasmic FMR1 Interacting Protein 1) is a Protein Coding gene. Diseases associated with CYFIP1 include angelman syndrome and fragile x syndrome. Among its related pathways are Regulation of actin cytoskeleton and ERK Signaling. GO annotations related to this gene include actin filament binding and Rac GTPase binding.

UniProtKB/Swiss-Prot for CYFIP1 Gene

  • Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit is an adapter between EIF4E and FMR1. Promotes the translation repression activity of FMR1 in brain probably by mediating its association with EIF4E and mRNA (By similarity). Regulates formation of membrane ruffles and lamellipodia. Plays a role in axon outgrowth. Binds to F-actin but not to RNA. Part of the WAVE complex that regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. Regulator of epithelial morphogenesis. May act as an invasion suppressor in cancers.

Gene Wiki entry for CYFIP1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYFIP1 Gene

Genomics for CYFIP1 Gene

Regulatory Elements for CYFIP1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CYFIP1 Gene

Start:
22,867,052 bp from pter
End:
22,981,063 bp from pter
Size:
114,012 bases
Orientation:
Minus strand

Genomic View for CYFIP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CYFIP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYFIP1 Gene

Proteins for CYFIP1 Gene

  • Protein details for CYFIP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7L576-CYFP1_HUMAN
    Recommended name:
    Cytoplasmic FMR1-interacting protein 1
    Protein Accession:
    Q7L576
    Secondary Accessions:
    • A8K6D9
    • Q14467
    • Q5IED0
    • Q6ZSX1
    • Q9BSD9
    • Q9BVC7

    Protein attributes for CYFIP1 Gene

    Size:
    1253 amino acids
    Molecular mass:
    145182 Da
    Quaternary structure:
    • Component of the WAVE1 complex composed of ABI2, CYFIP1 or CYFIP2, BRK1, NCKAP1 and WASF1/WAVE1. Within the complex, a heterdimer containing NCKAP1 and CYFIP1 interacts with a heterotrimer formed by WAVE1, ABI2 and BRK1. Component of the CYFIP1-EIF4E-FMR1 complex which is composed of CYFIP, EIF4E and FMR1. Interacts with FMR1 but does not bind to related proteins FXR1 or FXR2. Interaction with EIF4E stimulates FMR1 binding. Component of the WAVE2 complex composed of ABI1, CYFIP1/SRA1, NCKAP1/NAP1 and WASF2/WAVE2. Interacts with the active GTP-bound form of RAC1. Interacts through its C-terminus with the C-terminus of DPYSL2/CRMP2 which is necessary for DPYSL2-induced axon outgrowth. Interacts with NYAP1, NYAP2 and MYO16.
    Miscellaneous:
    • Breakpoint hotspot for the Prader-Willi/Angelman syndromes and may be implicated in autism. Commonly altered in tumors
    SequenceCaution:
    • Sequence=BAA07552.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CYFIP1 Gene

    Alternative splice isoforms for CYFIP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CYFIP1 Gene

Proteomics data for CYFIP1 Gene at MOPED

Post-translational modifications for CYFIP1 Gene

  • Ubiquitination at Lys97, Lys751, Lys1053, Lys1083, and Lys1210
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CYFIP1 Gene

Domains for CYFIP1 Gene

Suggested Antigen Peptide Sequences for CYFIP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7L576

UniProtKB/Swiss-Prot:

CYFP1_HUMAN :
  • Q7L576
Family:
  • Belongs to the CYFIP family.
genes like me logo Genes that share domains with CYFIP1: view

No data available for Gene Families for CYFIP1 Gene

Function for CYFIP1 Gene

Molecular function for CYFIP1 Gene

UniProtKB/Swiss-Prot Function: Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit is an adapter between EIF4E and FMR1. Promotes the translation repression activity of FMR1 in brain probably by mediating its association with EIF4E and mRNA (By similarity). Regulates formation of membrane ruffles and lamellipodia. Plays a role in axon outgrowth. Binds to F-actin but not to RNA. Part of the WAVE complex that regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. Regulator of epithelial morphogenesis. May act as an invasion suppressor in cancers.

Gene Ontology (GO) - Molecular Function for CYFIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11438699
GO:0032403 protein complex binding IMP 21107423
GO:0048365 Rac GTPase binding ISS --
GO:0051015 actin filament binding ISS --
genes like me logo Genes that share ontologies with CYFIP1: view

Phenotypes for CYFIP1 Gene

genes like me logo Genes that share phenotypes with CYFIP1: view

Animal Model Products

CRISPR Products

miRNA for CYFIP1 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CYFIP1 Gene

Localization for CYFIP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYFIP1 Gene

Cytoplasm, perinuclear region. Cell projection, lamellipodium. Cell projection, ruffle. Cell junction, synapse, synaptosome. Note=Highly expressed in the perinuclear region. Enriched in synaptosomes, membrane ruffles and at the tips of lamellipodia (By similarity). {ECO:0000250 UniProtKB:Q7TMB8}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CYFIP1 Gene COMPARTMENTS Subcellular localization image for CYFIP1 gene
Compartment Confidence
cytosol 2
nucleus 2
cytoskeleton 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CYFIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001726 ruffle ISS --
GO:0005737 cytoplasm --
GO:0005829 cytosol TAS --
GO:0005845 mRNA cap binding complex ISS --
GO:0005925 focal adhesion IDA 21423176
genes like me logo Genes that share ontologies with CYFIP1: view

Pathways for CYFIP1 Gene

genes like me logo Genes that share pathways with CYFIP1: view

Pathways by source for CYFIP1 Gene

3 Qiagen pathways for CYFIP1 Gene
1 BioSystems pathway for CYFIP1 Gene
2 KEGG pathways for CYFIP1 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for CYFIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0008360 regulation of cell shape IEA --
GO:0016601 Rac protein signal transduction IMP 21107423
GO:0030032 lamellipodium assembly ISS --
GO:0031529 ruffle organization ISS --
genes like me logo Genes that share ontologies with CYFIP1: view

Compounds for CYFIP1 Gene

(1) HMDB Compounds for CYFIP1 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
86-01-1
genes like me logo Genes that share compounds with CYFIP1: view

Transcripts for CYFIP1 Gene

Unigene Clusters for CYFIP1 Gene

Cytoplasmic FMR1 interacting protein 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CYFIP1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CYFIP1 Gene

No ASD Table

Relevant External Links for CYFIP1 Gene

GeneLoc Exon Structure for
CYFIP1
ECgene alternative splicing isoforms for
CYFIP1

Expression for CYFIP1 Gene

mRNA expression in normal human tissues for CYFIP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for CYFIP1 Gene

SOURCE GeneReport for Unigene cluster for CYFIP1 Gene Hs.26704

genes like me logo Genes that share expressions with CYFIP1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CYFIP1 Gene

Orthologs for CYFIP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CYFIP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CYFIP1 35
  • 99.41 (n)
  • 99.92 (a)
cow
(Bos Taurus)
Mammalia CYFIP1 35
  • 90.96 (n)
  • 99.04 (a)
mouse
(Mus musculus)
Mammalia Cyfip1 35
  • 90.21 (n)
  • 99.04 (a)
Cyfip1 16
rat
(Rattus norvegicus)
Mammalia Cyfip1 35
  • 89.78 (n)
  • 99.2 (a)
chicken
(Gallus gallus)
Aves CYFIP1 35
  • 82.07 (n)
  • 97.29 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cyfip1 35
  • 79.2 (n)
  • 94.25 (a)
Str.15568 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5585 35
zebrafish
(Danio rerio)
Actinopterygii cyfip1 35
  • 79.49 (n)
  • 92.57 (a)
Dr.1164 35
fruit fly
(Drosophila melanogaster)
Insecta Sra-1 37
  • 65 (a)
worm
(Caenorhabditis elegans)
Secernentea gex-2 35
  • 55.89 (n)
  • 52.29 (a)
Species with no ortholog for CYFIP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CYFIP1 Gene

ENSEMBL:
Gene Tree for CYFIP1 (if available)
TreeFam:
Gene Tree for CYFIP1 (if available)

Paralogs for CYFIP1 Gene

Selected SIMAP similar genes for CYFIP1 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with CYFIP1: view

No data available for Paralogs for CYFIP1 Gene

Variants for CYFIP1 Gene

Sequence variations from dbSNP and Humsavar for CYFIP1 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs7733 -- 22,869,605(-) TAGTT(C/G/T)TAAGT utr-variant-3-prime
rs14809 -- 22,869,578(-) TTTTT(G/T)TGTGT utr-variant-3-prime
rs719897 -- 22,935,028(+) AAAAT(A/G)GATCT intron-variant
rs722410 -- 22,948,971(+) AAAGG(A/C)AAAGG intron-variant
rs722411 -- 22,948,924(+) TCTTC(A/G)GGACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CYFIP1 Gene

Variant ID Type Subtype PubMed ID
dgv669e1 CNV Complex 17122850
dgv679e1 CNV Complex 17122850
dgv44n16 CNV Insertion 17901297
esv2751489 CNV Gain 17911159
esv34233 CNV Loss 17911159
essv13315 CNV CNV 17122850
nsv437797 CNV Loss 16327808
nsv511042 OTHER Inversion 20534489
nsv433429 CNV Gain 18776910
nsv903495 CNV Gain 21882294
esv2474417 CNV Loss 19546169
nsv442359 CNV CNV 18776908
dgv696e1 CNV Complex 17122850
nsv903498 CNV Gain 21882294
dgv2233n71 CNV Gain 21882294
dgv2234n71 CNV Loss 21882294
dgv2235n71 CNV Gain 21882294
dgv2236n71 CNV Gain+Loss 21882294
nsv433290 CNV Loss 18776910
dgv2238n71 CNV Loss 21882294
dgv2239n71 CNV Gain 21882294
nsv456612 CNV Loss 19166990
dgv287n27 CNV Gain 19166990
nsv471225 CNV Gain 18288195
nsv471226 CNV Loss 18288195
dgv2240n71 CNV Gain 21882294
esv34463 CNV Gain 17911159
essv24027 CNV CNV 17122850
dgv8n31 CNV Deletion 19718026
dgv2242n71 CNV Gain 21882294
essv13814 CNV CNV 17122850
nsv456636 CNV Loss 19166990
nsv469615 CNV Complex 16826518
nsv903549 CNV Loss 21882294
nsv903550 CNV Loss 21882294
dgv2243n71 CNV Gain 21882294
essv24315 CNV CNV 17122850
dgv2244n71 CNV Loss 21882294
nsv903553 CNV Loss 21882294
nsv903554 CNV Loss 21882294
dgv2245n71 CNV Loss 21882294
nsv832926 CNV Gain+Loss 17160897
esv2749402 CNV Deletion 23290073
esv2749403 CNV Deletion 23290073
esv2749404 CNV Deletion 23290073
nsv9184 CNV Loss 18304495
nsv903559 CNV Gain+Loss 21882294
nsv903560 CNV Loss 21882294
dgv2246n71 CNV Gain 21882294
nsv903562 CNV Loss 21882294
dgv2247n71 CNV Gain 21882294
essv25143 CNV CNV 17122850
essv19361 CNV CNV 17122850
nsv471376 CNV Deletion 19718026
dgv697e1 CNV Complex 17122850
nsv94774 CNV Insertion 16902084
esv2749405 CNV Deletion 23290073
esv2749406 CNV Deletion 23290073
nsv469667 CNV Loss 16826518
dgv9n31 CNV Deletion 19718026

Relevant External Links for CYFIP1 Gene

HapMap Linkage Disequilibrium report
CYFIP1
Human Gene Mutation Database (HGMD)
CYFIP1

PCR Panel Products

  • Copy Number PCR Panels: for CYFIP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CYFIP1 Gene

Disorders for CYFIP1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for CYFIP1 Gene including...

Search for CYFIP1 Gene in MalaCards »

(2) Novoseek inferred disease relationships for CYFIP1 Gene

Disease -log(P) Hits PubMed IDs
fragile x syndrome 72.4 1
mental retardation 68.1 1

Relevant External Links for CYFIP1

Genetic Association Database (GAD)
CYFIP1
Human Genome Epidemiology (HuGE) Navigator
CYFIP1
genes like me logo Genes that share disorders with CYFIP1: view

No data available for UniProtKB/Swiss-Prot for CYFIP1 Gene

Publications for CYFIP1 Gene

  1. A highly conserved protein family interacting with the fragile X mental retardation protein (FMRP) and displaying selective interactions with FMRP-related proteins FXR1P and FXR2P. (PMID: 11438699) Schenck A. … Mandel J.L. (Proc. Natl. Acad. Sci. U.S.A. 2001) 2 3 23
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. CRMP-2 is involved in kinesin-1-dependent transport of the Sra- 1/WAVE1 complex and axon formation. (PMID: 16260607) Kawano Y. … Kaibuchi K. (Mol. Cell. Biol. 2005) 3 4
  4. Genome-wide expression profiling of lymphoblastoid cell lines distinguishes different forms of autism and reveals shared pathways. (PMID: 17519220) Nishimura Y. … Geschwind D.H. (Hum. Mol. Genet. 2007) 3 23
  5. The fragile X syndrome protein represses activity-dependent translation through CYFIP1, a new 4E-BP. (PMID: 18805096) Napoli I. … Bagni C. (Cell 2008) 3 23

Products for CYFIP1 Gene

Sources for CYFIP1 Gene

Back to Top

Content