Aliases for CYFIP1 Gene
External Ids for CYFIP1 Gene
Previous GeneCards Identifiers for CYFIP1 Gene
GeneCards Summary for CYFIP1 Gene
CYFIP1 (Cytoplasmic FMR1 Interacting Protein 1) is a Protein Coding gene. Diseases associated with CYFIP1 include Fragile X Syndrome. Among its related pathways are Signaling by GPCR and Regulation of actin dynamics for phagocytic cup formation. GO annotations related to this gene include protein complex binding and Rac GTPase binding. An important paralog of this gene is CYFIP2.
UniProtKB/Swiss-Prot for CYFIP1 Gene
Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit is an adapter between EIF4E and FMR1. Promotes the translation repression activity of FMR1 in brain probably by mediating its association with EIF4E and mRNA (By similarity). Regulates formation of membrane ruffles and lamellipodia. Plays a role in axon outgrowth. Binds to F-actin but not to RNA. Part of the WAVE complex that regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. Regulator of epithelial morphogenesis. May act as an invasion suppressor in cancers.