CYFIP1 Gene
protein-coding GIFtS: 62
GCID: GC15P023843
|
|
cytoplasmic FMR1 interacting protein 1
| |
Aliases
for CYFIP1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Cytoplasmic FMR1 Interacting Protein 11 2 | | Cytoplasmic FMR1-Interacting Protein 12 | | KIAA00681 3 5 | | Cytoplasmic FMRP Interacting Protein 12 | | P140SRA-11 2 | | Selective Hybridizing Clone2 | | SHYC1 2 | | Sra-13 | | Specifically Rac1-Associated Protein 12 3 | | Sra-13 | | SRA12 | | P140sra-11 |
Export aliases for CYFIP1 gene to outside databasesPrevious GC identifers: GC15P019172 GC15M015990 GC15P020311 GC15P020440 GC15P020444 GC15P023697 GC15P023717 GC15P001205 GC15P023748 GC15P023761 GC15P023780 GC15P023809 |
Summaries
for CYFIP1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: CYFP1_HUMAN, Q7L576Function: Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression.In the CYFIP1-EIF4E-FMR1 complex this subunit is an adapter between EIF4E and FMR1. Promotes the translationrepression activity of FMR1 in brain probably by mediating its association with EIF4E and mRNA (By similarity).Regulates formation of membrane ruffles and lamellipodia. Plays a role in axon outgrowth. Binds to F-actin but not toRNA. Part of the WAVE complex that regulates actin filament reorganization via its interaction with the Arp2/3complex. Actin remodeling activity is regulated by RAC1. Regulator of epithelial morphogenesis. May act as an invasionsuppressor in cancers
Gene Wiki entry for CYFIP1
|
Genomic Views
for CYFIP1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000015.9 NC_018926.1 NT_078094.2
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CYFIP1 gene promoter:
NF-1/L NF-1 AML1a FOXO3 FOXO3a STAT5A E47 FOXO3b
Other transcription factors
Search SABiosciences Chromatin IP Primers for CYFIP1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CYFIP1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 15q11 Ensembl cytogenetic band: 15q11.2 HGNC cytogenetic band: 15q11CYFIP1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 15 GeneLoc Exon Structure GeneLoc location for GC15P023843: view genomic region
(about GC identifiers)
Start:
|
22,892,005 bp from pter |
End:
|
23,006,016 bp from pter |
Size:
|
114,012 bases |
Orientation:
|
plus strand |
|
Proteins
for CYFIP1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CYFP1_HUMAN, Q7L576 (See
protein sequence)Recommended Name: Cytoplasmic FMR1-interacting protein 1 Size: 1253 amino acids; 145182 Da
Subunit: Component of the WAVE1 complex composed of ABI2, CYFIP1 or CYFIP2, BRK1, NCKAP1 and WASF1/WAVE1. Within thecomplex, a heterdimer containing NCKAP1 and CYFIP1 interacts with a heterotrimer formed by WAVE1, ABI2 and BRK1.Component of the CYFIP1-EIF4E-FMR1 complex which is composed of CYFIP, EIF4E and FMR1. Interacts with FMR1 but doesnot bind to related proteins FXR1 or FXR2. Interaction with EIF4E stimulates FMR1 binding. Component of the WAVE2complex composed of ABI1, CYFIP1/SRA1, NCKAP1/NAP1 and WASF2/WAVE2. Interacts with the active GTP-bound form of RAC1.Interacts through its C-terminus with the C-terminus of DPYSL2/CRMP2 which is necessary for DPYSL2-induced axonoutgrowth. Interacts with NYAP1, NYAP2 and MYO16
Subcellular location: Cytoplasm, perinuclear region (By similarity). Cell projection, lamellipodium (By similarity).Cell projection, ruffle (By similarity). Cell junction, synapse, synaptosome (By similarity). Note=Highly expressed inthe perinuclear region. Enriched in synaptosomes, membrane ruffles and at the tips of lamellipodia (By similarity)
Miscellaneous: Breakpoint hotspot for the Prader-Willi/Angelman syndromes and may be implicated in autism. Commonlyaltered in tumors
Sequence caution: Sequence=BAA07552.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
1 PDB 3D structure from  and Proteopedia  for CYFIP1:3P8C (3D)
Secondary accessions: A8K6D9 Q14467 Q5IED0 Q6ZSX1 Q9BSD9 Q9BVC7Alternative splicing: 3 isoforms: Q7L576-1 Q7L576-2 Q7L576-3 Explore the universe of human proteins at neXtProt for CYFIP1: NX_Q7L576
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q7L576
CYFIP1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001028200.1 NP_055423.1
ENSEMBL proteins: ENSP00000453046 ENSP00000324549 ENSP00000453233 ENSP00000454199 ENSP00000454091 ENSP00000453917 ENSP00000454045 ENSP00000405956 ENSP00000453060
Human Recombinant Protein Products:
Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8): About this table
CYFIP1 for ontologies About GeneDecksing
CYFIP1 Antibody Products:
Assay Products for CYFIP1: |
Protein
Domains /
Families
for CYFIP1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CYFIP1 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q7L576ProtoNet protein and cluster: Q7L576 1 Blocks protein family: IPB008081 Cytoplasmic fragile X mental retardation protein interacting protein signature
UniProtKB/Swiss-Prot: CYFP1_HUMAN, Q7L576Similarity: Belongs to the CYFIP family |
Function
for CYFIP1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: CYFP1_HUMAN, Q7L576Function: Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression.In the CYFIP1-EIF4E-FMR1 complex this subunit is an adapter between EIF4E and FMR1. Promotes the translationrepression activity of FMR1 in brain probably by mediating its association with EIF4E and mRNA (By similarity).Regulates formation of membrane ruffles and lamellipodia. Plays a role in axon outgrowth. Binds to F-actin but not toRNA. Part of the WAVE complex that regulates actin filament reorganization via its interaction with the Arp2/3complex. Actin remodeling activity is regulated by RAC1. Regulator of epithelial morphogenesis. May act as an invasionsuppressor in cancers
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CYFIP1 (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CYFIP1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): CYFIP1 (NM_001033028) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CYFIP1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CYFIP1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYFIP1 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
CYFIP1 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for CYFIP1:
Animal Models:
3 MGI mutant phenotypes (inferred from 4 alleles ) (MGI details for Cyfip1):
CYFIP1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for CYFIP1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Rho Family GTPases | | | 2 | Apoptotic Pathways in Synovial Fibroblasts | | | 3 | Regulation of Actin Cytoskeleton | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CYFIP1
1 
Kegg Pathway (Kegg details for CYFIP1):
CYFIP1 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CYFIP1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/57 Interacting proteins for CYFIP1 (Q7L5761, 2, 3 ENSP000003245494) via UniProtKB, MINT, STRING, and/or I2D (see all 57)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| GAS7 | O608612, 3, ENSP000003226084 | MINT-72913 I2D:
score=2 STRING: ENSP00000322608 | | ABI1 | Q8IZP02, 3, ENSP000003653124 | MINT-45994 I2D:
score=1 STRING: ENSP00000365312 | | FMR1 | Q067871, 2, 3, ENSP000003595064 | EBI-1048143,EBI-366305 MINT-19272 MINT-19271 MINT-19273 I2D:
score=7 STRING: ENSP00000359506 | | NCKAP1 | Q9Y2A71, 2, 3, ENSP000003542514 | EBI-1048143,EBI-389845 MINT-8307391 I2D:
score=2 STRING: ENSP00000354251 | | ACTA1 | P681333, ENSP000003556454 | I2D:
score=2 STRING: ENSP00000355645 |
About this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table
CYFIP1 for ontologies About GeneDecksing
|
Drugs & Compounds
for CYFIP1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CYFIP1
1 HMDB Compound for CYFIP1 About this table
Search CenterWatch for drugs/clinical trials and news about CYFIP1 / CYFP1
|
Transcripts
for CYFIP1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CYFIP1 gene (2 alternative transcripts): NM_001033028.1 NM_014608.2 Unigene Cluster for CYFIP1: Cytoplasmic FMR1 interacting protein 1 Hs.26704 [show with all ESTs]Unigene Representative Sequence: AK12709414 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000561185 ENST00000313077(uc001yus.3) ENST00000561274 ENST00000560848(uc001yut.3 uc010aya.1)
ENST00000558430 ENST00000559393 ENST00000557859 ENST00000558549 ENST00000435939(uc001yuu.3)
ENST00000558826 ENST00000561296 ENST00000561020(uc001yuv.3) ENST00000557890
ENST00000561263
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CYFIP1 (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CYFIP1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): CYFIP1 (NM_001033028) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CYFIP1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CYFIP1 |
Additional cDNA sequence: AK024816.1 AK125784.1 AK125936.1 AK127094.1 AK291604.1 AL357618.1 AY763577.1 AY763578.1 AY763579.1 AY763580.1 BC001306.2 BC005097.1 BC063869.1 BC118566.1 BC118646.1 D38549.1 24 DOTS entries: DT.97813683 DT.417613 DT.91865366 DT.95120668 DT.100793753 DT.121069748 DT.100810327 DT.451960 DT.101984967 DT.101984966 DT.100793752 DT.100044762 DT.100834953 DT.121069777 DT.99970876 DT.121069792 DT.121069810 DT.40266447 DT.95120667 DT.95120669 DT.95120670 DT.75115206 DT.92439746 DT.97760020 24/429 AceView cDNA sequences (see all 429): AA478821 BQ006326 AA970370 AL557701 BQ643770 BQ002490 BU684453 AI801614 AI057523 AI752059 AK125936 AW300619 N66002 BM796917 BU152835 BM673358 AA860219 BM727801 H89287 AA456560 BX356445 BU786870 AA778837 BQ231860
GeneLoc Exon Structure
5/12 Alternative Splicing Database (ASD) splice patterns (SP) for CYFIP1 (see all 12) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18a | · | 18b | · | 18c | ^ | 19a | · | 19b | ^ |
|---|
|
| SP1: | | | | | - | | | | - | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | |
| SP2: | | | | | - | | - | | - | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | |
| SP3: | | | | | | | - | | - | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 20a | · | 20b | ^ | 21a | · | 21b | · | 21c | ^ | 22 | ^ | 23 | ^ | 24 | ^ | 25 | ^ | 26a | · | 26b | · | 26c | ^ | 27 | ^ | 28a | · | 28b | ^ | 29 | ^ | 30a | · | 30b | ^ | 31 | ^ | 32a | · | 32b | ^ | 33 | ^ | 34 | ^ | 35 | ^ | 36a | · | 36b |
|---|
|
| SP1: | - | | | | - | | | | - | | | | | | | | | | - | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | |
| SP2: | - | | | | - | | | | - | | | | | | | | | | - | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | |
| SP3: | - | | | | - | | | | - | | | | | | | | | | - | | | | | | | | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | |
| SP4: | | | | | - | | | | - | | | | | | | | | | - | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for CYFIP1
|
Expression
for CYFIP1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CYFIP1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCTTTCTCTC
About this image
See CYFIP1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CYFIP1
SOURCE GeneReport for Unigene cluster: Hs.26704
SABiosciences Expression via Pathway-Focused PCR Array including CYFIP1:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CYFIP1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CYFIP1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CYFIP1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CYFIP1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYFIP1 |
Orthologs
for CYFIP1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for CYFIP1 gene from 8/25 species (see all 25) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
CYFIP11 |
cytoplasmic FMR1 interacting protein 1 |
82.07(n)
97.29(a) |
|
418677 XM_003640523.1 XP_003640571.1 |
lizard
(Anolis carolinensis) |
Reptilia |
CYFIP16 |
-- |
90(a) |
1 ↔ 1 |
3(111762059-111821064) |
tropical clawed frog
(Xenopus tropicalis) |
Amphibia |
Str.155682 |
Transcribed sequence with moderate similarity to protein more |
77.86(n) |
|
BX728347.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.11642 |
Danio rerio Cyfip mRNA, complete cds |
80.02(n) |
|
AY017342.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Sra-13 |
Rho interactor |
65(a) |
|
88F1 -- |
worm
(Caenorhabditis elegans) |
Secernentea |
gex-21 |
Protein GEX-2 |
55.89(n)
52.29(a) |
|
176885 NM_067548.3 NP_499949.2 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
PIR6 |
protein PIR |
26(a) |
1 → many |
5(6097271-6105031) |
rice
(Oryza sativa) |
Liliopsida |
-- |
PIR, putative, expressed |
27(a) |
1 → many |
3(2431918-2448211) |
ENSEMBL Gene Tree for CYFIP1 (if available)
TreeFam Gene Tree for CYFIP1 (if available) |
Paralogs
for CYFIP1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CYFIP1 gene
- CYFIP22
2 SIMAP similar genes for CYFIP1 using alignment to 7 protein entries: CYFP1_HUMAN (see all proteins):CYFIP2 DKFZp761H087
CYFIP1 for paralogs About GeneDecksing
|
Genomic Variants
for CYFIP1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 15 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CYFIP1 (22892005 - 23006016 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 22 variations for CYFIP1
15/21 CNVs (see all 21): 38872 4878 37594 49473 9256 9251 49472 1281 49471 102046 8787 3070 3951 34608 34529
1 Indel: 33590 | SABiosciences Cancer Mutation PCR Assays |
| 1 SABiosciences qBiomarker Copy Number PCR Array containing CYFIP1: |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CYFIP1 |
|
Disorders
/ Diseases
for CYFIP1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CYFIP1 for disorders About GeneDecksing
OMIM gene information: 606322
OMIM disorders: --
6  diseases for CYFIP1: About MalaCardsfragile x syndrome prader-willi syndrome intellectual disability angelman syndrome
schizophrenia neuronitis
4 diseases from the University of Copenhagen DISEASES database for CYFIP1:Autistic disorder Angelman syndrome Prader-Willi syndrome Intellectual disability 2 Novoseek disease relationships for CYFIP1 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| fragile x syndrome |
72.4 |
1 |
18805096 (1) |
| mental retardation |
68.1 |
2 |
20298200 (1) |
Human Genome Epidemiology (HuGE) Navigator: CYFIP1 (1 document)
Export disorders for CYFIP1 gene to outside databases
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Publications
for CYFIP1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
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PubMed articles for CYFIP1 gene, integrated from 9 sources (see all 34):
(articles sorted by number of sources associating them with CYFIP1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A highly conserved protein family interacting with the fragile X mental retardation protein (FMRP) and displaying selective interactions with FMRP-related proteins FXR1P and FXR2P. (PubMed id 11438699)1, 3, 9 Schenck A....Mandel J.L. (2001)
- Cyfip1 is a putative invasion suppressor in epithelia l cancers. (PubMed id 19524508)1, 2 Silva J.M....Hannon G.J. (2009)
- CRMP-2 is involved in kinesin-1-dependent transport of the Sra- 1/WAVE1 complex and axon formation. (PubMed id 16260607)1, 2 Kawano Y.... Kaibuchi K. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- p140Sra-1 (specifically Rac1-associated protein) is a novel specific target for Rac1 small GTPase. (PubMed id 9417078)1, 2 Kobayashi K.... Kaibuchi K. (1998)
- Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 7584044)1, 2 Nomura N....Tabata S. (1994)
- The fragile X syndrome protein represses activity-dependent translation through CYFIP1, a new 4E-BP. (PubMed id 18805096)1, 9 Napoli I....Bagni C. (2008)
- Confirmed rare copy number variants implicate novel g enes in schizophrenia. (PubMed id 20298200)1, 9 Tam G.W....Grant S.G. (2010)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
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External Searches for CYFIP1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing CYFIP1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing CYFIP1 gene
(According to HUGE)
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Specialized Databases showing CYFIP1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Name | Description |
| PharmGKB entry for CYFIP1 | Pharmacogenomics, SNPs, Pathways |
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| Patent Information for CYFIP1 gene:
Search GeneIP for patents involving CYFIP1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for CYFIP1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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