Aliases for CYCS Gene
External Ids for CYCS Gene
- HGNC: 19986
- Entrez Gene: 54205
- Ensembl: ENSG00000172115
- OMIM: 123970
- UniProtKB: P99999
Previous GeneCards Identifiers for CYCS Gene
- GC07M024801
- GC07M024900
- GC07M024931
- GC07M025124
Summaries for CYCS Gene
-
This gene encodes a small heme protein that functions as a central component of the electron transport chain in mitochondria. The encoded protein associates with the inner membrane of the mitochondrion where it accepts electrons from cytochrome b and transfers them to the cytochrome oxidase complex. This protein is also involved in initiation of apoptosis. Mutations in this gene are associated with autosomal dominant nonsyndromic thrombocytopenia. Numerous processed pseudogenes of this gene are found throughout the human genome.[provided by RefSeq, Jul 2010]
GeneCards Summary for CYCS Gene
CYCS (Cytochrome C, Somatic) is a Protein Coding gene. Diseases associated with CYCS include Thrombocytopenia 4 and Autosomal Thrombocytopenia With Normal Platelets. Among its related pathways are Development HGF signaling pathway and Apoptosis and survival Caspase cascade. GO annotations related to this gene include iron ion binding and electron carrier activity.
UniProtKB/Swiss-Prot for CYCS Gene
-
Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
-
Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYCS Gene
Genomics for CYCS Gene
Regulatory Elements for CYCS Gene
Enhancers for CYCS Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH07G025123 | 1.2 | ENCODE | 9.4 | -0.4 | -448 | 4.1 | HDGF PKNOX1 MLX CREB3L1 ARNT AGO1 WRNIP1 ARID4B SIN3A DMAP1 | DFNA5 CYCS OSBPL3 PIR56122 |
| GH07G025093 | 1.2 | Ensembl ENCODE | 7.6 | +31.3 | 31346 | 1.2 | HDAC1 HDGF PKNOX1 FOXA2 RB1 ARNT ARID4B ZNF2 ZBTB40 RAD21 | CYCS GC07P025051 |
| GH07G025149 | 0.6 | ENCODE | 10.2 | -24.5 | -24455 | 0.7 | SOX5 FOSL1 SOX13 ZNF316 JUND ATF3 TEAD4 | CYCS OSBPL3 PIR38469 PIR55615 |
| GH07G025116 | 1.1 | Ensembl ENCODE | 5.3 | +7.7 | 7741 | 2.3 | HDGF PKNOX1 ZBTB40 RELB IKZF2 CREM PAF1 MIER1 JUNB GATAD2B | CYCS GC07P025051 |
| GH07G024910 | 1.7 | FANTOM5 Ensembl ENCODE dbSUPER | 1.4 | +214.2 | 214238 | 2.0 | HDAC1 TBP ATF1 TBL1XR1 FEZF1 TCF12 ZNF766 GATA2 EGR1 RELB | OSBPL3 CYCS SNRPCP19 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around CYCS on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the CYCS gene promoter:
Regulatory Element Products
Genomic Location for CYCS Gene
- Chromosome:
- 7
- Start:
- 25,118,651 bp from pter
- End:
- 25,125,361 bp from pter
- Size:
- 6,711 bases
- Orientation:
- Minus strand
Genomic View for CYCS Gene
Genes around CYCS on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 7p15.3 by Ensembl
- 7p15.3 by Entrez Gene
- 7p15.3 by HGNC
CYCS Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CYCS Gene
Proteins for CYCS Gene
-
Protein details for CYCS Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P99999-CYC_HUMAN
- Recommended name:
- Cytochrome c
- Protein Accession:
- P99999
- A4D166
- B2R4I1
- P00001
- Q6NUR2
- Q6NX69
- Q96BV4
Protein attributes for CYCS Gene
- Size:
- 105 amino acids
- Molecular mass:
- 11749 Da
- Quaternary structure:
- No Data Available
Protein Expression for CYCS Gene
Post-translational modifications for CYCS Gene
- Binds 1 heme group per subunit.
- Phosphorylation at Tyr-49 and Tyr-98 both reduce by half the turnover in the reaction with cytochrome c oxidase, down-regulating mitochondrial respiration.
- Ubiquitination at isoforms=40 and Lys80
- Modification sites at PhosphoSitePlus
Other Protein References for CYCS Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for CYCS
- R&D Systems Antibodies for CYCS (Cytochrome c)
- Cell Signaling Technology (CST) Antibodies for CYCS (CYCS)
- Novus Biologicals Antibodies for CYCS
-
Abcam antibodies for CYCS
-
Cloud-Clone Corp. Antibodies for CYCS
- Invitrogen Antibodies for CYCS
- antibodies-online Antibodies for CYCS: See all 260
- GeneTex CYCS antibody for CYCS
-
Santa Cruz Biotechnology (SCBT) Antibodies for CYCS
Protein Products
- R&D Systems Proteins and Enzymes for CYCS (Cytochrome c)
-
OriGene Purified Proteins for CYCS
- Search Origene for MassSpec and Protein Over-expression Lysates for CYCS
- Origene Custom Protein Services for CYCS
-
Cloud-Clone Corp. Proteins for CYCS
- antibodies-online Proteins for CYCS: See all 96
- Search antibodies-online for peptides
- GeneTex Proteins for CYCS
-
ProSci Proteins for CYCS
-
Abcam proteins for CYCS
Assay Products
- R&D Systems ELISAs, Proteome Profiler Antibody Arrays, and other biochemical assays for CYCS (Cytochrome c)
- eBioscience Human Cytochrome c Platinum ELISA 96 tests and Human Cytochrome c Matched Antibody Pairs 10 x 96 tests for CYCS
- antibodies-online Kits for CYCS: See all 82
-
Abcam assays for CYCS
No data available for DME Specific Peptides for CYCS Gene
Domains & Families for CYCS Gene
Protein Domains for CYCS Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for CYCS Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P99999- Family:
-
- Belongs to the cytochrome c family.
No data available for Gene Families for CYCS Gene
Function for CYCS Gene
Molecular function for CYCS Gene
- UniProtKB/Swiss-Prot Function:
- Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
- UniProtKB/Swiss-Prot Function:
- Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004722 | contributes_to protein serine/threonine phosphatase activity | TAS | 8206937 |
| GO:0005515 | protein binding | IPI | 9267021 |
| GO:0009055 | electron carrier activity | IEA | -- |
| GO:0020037 | heme binding | IEA,TAS | 9515723 |
| GO:0045155 | electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity | IDA | 8689682 |
Phenotypes for CYCS Gene
- MGI mutant phenotypes for CYCS:
-
inferred from 3 alleles
- mortality/aging
- cellular phenotype
- behavior/neurological phenotype
- growth/size/body region phenotype
- immune system phenotype
- nervous system phenotype
- cardiovascular system phenotype
- endocrine/exocrine gland phenotype
- skeleton phenotype
- embryo phenotype
- hematopoietic system phenotype
- craniofacial phenotype
- GenomeRNAi human phenotypes for CYCS:
Animal Models for CYCS Gene
- MGI Knock Outs for CYCS:
-
- Cycs tm1Wlm
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for CYCS
-
-
ViGene Biosciences lentiviral particle packaged cDNA for CYCS gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CYCS gene
- Search ViGene Biosciences for CYCS
CRISPR Products
-
OriGene CRISPR knockouts for CYCS
-
Santa Cruz Biotechnology (SCBT) CRISPR for CYCS
- GenScript: Design CRISPR guide RNA sequences for CYCS
miRNA for CYCS Gene
- miRTarBase miRNAs that target CYCS
-
- hsa-mir-148a-3p (MIRT025976)
- hsa-mir-16-5p (MIRT031466)
- hsa-mir-320c (MIRT036158)
- hsa-mir-93-3p (MIRT038787)
- hsa-mir-361-5p (MIRT044075)
- hsa-mir-21-3p (MIRT320232)
- hsa-mir-1306-5p (MIRT320237)
- hsa-mir-3591-3p (MIRT320239)
- hsa-mir-6878-3p (MIRT524257)
- hsa-mir-5089-5p (MIRT524258)
- hsa-mir-6811-5p (MIRT524259)
- hsa-mir-6511b-5p (MIRT524260)
- hsa-mir-215-5p (MIRT524261)
- hsa-mir-192-5p (MIRT524262)
- hsa-mir-6744-3p (MIRT524263)
- hsa-mir-4757-5p (MIRT524264)
- hsa-mir-5589-5p (MIRT524265)
- hsa-mir-4731-5p (MIRT524266)
- hsa-mir-4312 (MIRT524267)
- hsa-mir-6778-3p (MIRT524268)
- hsa-mir-6797-3p (MIRT524269)
- hsa-mir-6076 (MIRT524270)
- hsa-mir-6506-5p (MIRT524271)
- hsa-mir-619-5p (MIRT524272)
- hsa-mir-150-5p (MIRT524273)
- hsa-mir-212-5p (MIRT524274)
- hsa-mir-186-3p (MIRT524275)
- hsa-mir-520h (MIRT524276)
- hsa-mir-520g-3p (MIRT524277)
- hsa-mir-512-3p (MIRT524278)
- hsa-mir-520e (MIRT524279)
- hsa-mir-520d-3p (MIRT524280)
- hsa-mir-520c-3p (MIRT524281)
- hsa-mir-520b (MIRT524282)
- hsa-mir-520a-3p (MIRT524283)
- hsa-mir-373-3p (MIRT524284)
- hsa-mir-372-3p (MIRT524285)
- hsa-mir-302e (MIRT524286)
- hsa-mir-302d-3p (MIRT524287)
- hsa-mir-302c-3p (MIRT524288)
- hsa-mir-302b-3p (MIRT524289)
- hsa-mir-302a-3p (MIRT524290)
- hsa-mir-93-5p (MIRT524291)
- hsa-mir-526b-3p (MIRT524292)
- hsa-mir-519d-3p (MIRT524293)
- hsa-mir-20b-5p (MIRT524294)
- hsa-mir-20a-5p (MIRT524295)
- hsa-mir-17-5p (MIRT524296)
- hsa-mir-106b-5p (MIRT524297)
- hsa-mir-106a-5p (MIRT524298)
- hsa-mir-7977 (MIRT629109)
- hsa-mir-2861 (MIRT629110)
- hsa-mir-4763-3p (MIRT629111)
- hsa-mir-1207-5p (MIRT629112)
- hsa-mir-6836-5p (MIRT629113)
- hsa-mir-6132 (MIRT629114)
- hsa-mir-4456 (MIRT629115)
- hsa-mir-3918 (MIRT629116)
- hsa-mir-4512 (MIRT629117)
- hsa-mir-498 (MIRT668825)
- hsa-mir-4279 (MIRT668826)
- hsa-mir-4713-5p (MIRT668827)
- hsa-mir-3671 (MIRT668828)
- hsa-mir-1976 (MIRT668829)
- hsa-mir-3653-5p (MIRT668830)
- hsa-mir-2116-3p (MIRT668831)
- hsa-mir-532-3p (MIRT668832)
- hsa-mir-372-5p (MIRT668833)
- hsa-mir-371a-5p (MIRT668834)
- hsa-mir-616-5p (MIRT668835)
- hsa-mir-373-5p (MIRT668836)
- hsa-mir-371b-5p (MIRT668837)
- hsa-mir-6747-3p (MIRT668838)
- hsa-mir-6727-3p (MIRT668839)
- hsa-mir-4722-3p (MIRT668840)
- hsa-mir-4726-3p (MIRT668841)
- hsa-mir-6764-5p (MIRT668842)
- hsa-mir-1915-3p (MIRT668843)
- hsa-mir-6840-3p (MIRT668844)
- hsa-mir-22-3p (MIRT668845)
- hsa-mir-6877-3p (MIRT668846)
- hsa-mir-6819-3p (MIRT668847)
- hsa-mir-8057 (MIRT668848)
- hsa-mir-4772-3p (MIRT668849)
- hsa-mir-4284 (MIRT668850)
- hsa-mir-1304-3p (MIRT668851)
- hsa-mir-6814-5p (MIRT668852)
- hsa-mir-6890-3p (MIRT668853)
- hsa-mir-5096 (MIRT673634)
- hsa-mir-6848-3p (MIRT673635)
- hsa-mir-6855-5p (MIRT673636)
- hsa-mir-6843-3p (MIRT673637)
- hsa-mir-3170 (MIRT673638)
- hsa-mir-3187-3p (MIRT673639)
- hsa-mir-4435 (MIRT673640)
- hsa-mir-588 (MIRT673641)
- hsa-mir-4701-5p (MIRT673642)
- hsa-mir-548s (MIRT673643)
- hsa-mir-514b-5p (MIRT673644)
- hsa-mir-513c-5p (MIRT673645)
- hsa-mir-378a-5p (MIRT673646)
- hsa-mir-197-3p (MIRT673647)
- hsa-mir-193b-5p (MIRT673648)
- hsa-mir-6131 (MIRT673649)
- hsa-mir-4755-3p (MIRT673650)
- hsa-mir-1273f (MIRT673651)
- hsa-mir-3663-5p (MIRT673652)
- hsa-mir-4716-5p (MIRT673653)
- hsa-mir-4781-3p (MIRT673654)
- hsa-mir-6890-5p (MIRT673655)
- hsa-mir-665 (MIRT688589)
- hsa-mir-7160-5p (MIRT688590)
- hsa-mir-4722-5p (MIRT688591)
- hsa-mir-891b (MIRT688592)
- hsa-mir-6884-5p (MIRT688593)
- hsa-mir-485-5p (MIRT688594)
- hsa-mir-1827 (MIRT688595)
- hsa-mir-4649-3p (MIRT688596)
- hsa-mir-3664-3p (MIRT688597)
- hsa-mir-4768-3p (MIRT688598)
- hsa-mir-3614-5p (MIRT688599)
- hsa-mir-4478 (MIRT688600)
- hsa-mir-4419b (MIRT688601)
- hsa-mir-3929 (MIRT688602)
- hsa-mir-940 (MIRT688603)
- hsa-mir-6893-5p (MIRT688604)
- hsa-mir-6808-5p (MIRT688605)
- hsa-mir-4695-5p (MIRT688606)
- hsa-mir-510-5p (MIRT688607)
- hsa-mir-34b-3p (MIRT688608)
- hsa-mir-3926 (MIRT714473)
- hsa-mir-494-3p (MIRT714474)
- hsa-mir-3922-3p (MIRT714475)
- hsa-mir-3176 (MIRT714476)
- hsa-mir-3190-5p (MIRT714477)
- hsa-mir-622 (MIRT714478)
miRNA Products
- Search ViGene Biosciences for CYCS
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CYCS
- Browse OriGene Inhibitory RNA Products For CYCS
-
ViGene Biosciences ready-to-package AAV shRNAs for CYCS gene
Clone Products
- Sino Biological Human cDNA Clone for CYCS
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for CYCS
- VectorBuilder custom plasmid, inducible vectors for CYCS
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CYCS
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for CYCS
-
ViGene Biosciences adenoviral particle packaged cDNA for CYCS gene
-
ViGene Biosciences lentiviral particle packaged cDNA for CYCS gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CYCS gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CYCS Gene
Localization for CYCS Gene
Subcellular locations from UniProtKB/Swiss-Prot for CYCS Gene
- Mitochondrion intermembrane space. Note=Loosely associated with the inner membrane.
| Compartment | Confidence |
|---|---|
| mitochondrion | 5 |
| nucleus | 5 |
| cytosol | 5 |
| plasma membrane | 2 |
| extracellular | 2 |
| cytoskeleton | 2 |
| endoplasmic reticulum | 2 |
| lysosome | 2 |
| peroxisome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000159 | protein phosphatase type 2A complex | TAS | 8206937 |
| GO:0005634 | nucleus | IDA | 21630459 |
| GO:0005739 | mitochondrion | IEA,IDA | 20671748 |
| GO:0005743 | mitochondrial inner membrane | TAS | -- |
| GO:0005758 | mitochondrial intermembrane space | TAS | 8689682 |
Pathways & Interactions for CYCS Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | TNFR1 Pathway |
.87
.87
.56
.55
|
.40
.35
|
| 2 | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. | ||
| 3 | Apoptosis Modulation and Signaling |
.41
|
.33
|
| 4 | Nanomaterial induced apoptosis | ||
| 5 | Apoptotic Pathways in Synovial Fibroblasts |
.74
|
|
Pathways by source for CYCS Gene
1 Sino Biological pathway for CYCS Gene
2 GeneTex pathways for CYCS Gene
1 Cell Signaling Technology pathway for CYCS Gene
15 BioSystems pathways for CYCS Gene
2 PharmGKB pathways for CYCS Gene
21 KEGG pathways for CYCS Gene
10 GeneGo (Thomson Reuters) pathways for CYCS Gene
3 R&D Systems pathways for CYCS Gene
29 Qiagen pathways for CYCS Gene
Interacting Proteins for CYCS Gene
Selected Interacting proteins:
P99999-CYC_HUMAN
ENSP00000307786
for CYCS Gene via
MINT
STRING
UniProtKB
IID
SIGNOR curated interactions for CYCS Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000302 | response to reactive oxygen species | TAS | -- |
| GO:0006122 | mitochondrial electron transport, ubiquinol to cytochrome c | TAS | -- |
| GO:0006123 | mitochondrial electron transport, cytochrome c to oxygen | TAS | -- |
| GO:0006470 | protein dephosphorylation | IEA | -- |
| GO:0006915 | apoptotic process | IEA | -- |
Drugs & Compounds for CYCS Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Minocycline | Approved, Investigational | Pharma | Target, negative modulator | 231 | ||
| Heme C | Experimental | Pharma | Target | 0 | ||
| N-Trimethyllysine | Experimental | Pharma | Target | 0 | ||
| Protoporphyrin Ix Containing Co | Experimental | Pharma | Target | 0 | ||
| Protoporphyrin Ix Containing Zn | Experimental | Pharma | Target | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
(1) ApexBio Compounds for CYCS Gene
| Compound | Action | Cas Number |
|---|---|---|
| Cytochrome c - pigeon (88-104) | Triggers T Cell response | 86579-06-8 |
Drug Products
- ApexBio compounds for CYCS
Transcripts for CYCS Gene
mRNA/cDNA for CYCS Gene
- (1) REFSEQ mRNAs :
- (2051) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for CYCS
-
Santa Cruz Biotechnology (SCBT) CRISPR for CYCS
- GenScript: Design CRISPR guide RNA sequences for CYCS
miRNA Products
- Search ViGene Biosciences for CYCS
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CYCS
- Browse OriGene Inhibitory RNA Products For CYCS
-
ViGene Biosciences ready-to-package AAV shRNAs for CYCS gene
Clone Products
- Sino Biological Human cDNA Clone for CYCS
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for CYCS
- VectorBuilder custom plasmid, inducible vectors for CYCS
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CYCS
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
Expression for CYCS Gene
mRNA differential expression in normal tissues according to GTEx for CYCS Gene
This gene is overexpressed in Heart - Left Ventricle (x5.4) and Heart - Atrial Appendage (x4.1).
This gene is overexpressed in Serum (6.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CYCS Gene
NURSA nuclear receptor signaling pathways regulating expression of CYCS Gene:
CYCSSOURCE GeneReport for Unigene cluster for CYCS Gene:
Hs.437060Evidence on tissue expression from TISSUES for CYCS Gene
- Nervous system(5)
- Liver(4.9)
- Kidney(4.8)
- Heart(4.7)
- Muscle(4.3)
- Lung(4.2)
- Skin(4.2)
- Intestine(3.8)
- Blood(3.4)
- Eye(3.1)
- Adrenal gland(3)
- Stomach(2.7)
- Bone marrow(2.5)
- Pancreas(2.5)
- Lymph node(2.3)
- Spleen(2.3)
- Bone(2.2)
- Thyroid gland(2.1)
Phenotype-based relationships between genes and organs from Gene ORGANizer for CYCS Gene
Germ Layers:
- ectoderm
- mesoderm
Systems:
- cardiovascular
- integumentary
- skeleton
Organs:
General:
- blood
- blood vessel
- coagulation system
- skin
Primer Products
-
OriGene qPCR primer pairs and template standards for CYCS
-
OriGene qPCR primer pairs for CYCS
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for CYCS Gene
Orthologs for CYCS Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CYCS 35 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | CYCS 34 35 |
|
||
| -- 35 |
|
ManyToMany | |||
| mouse (Mus musculus) |
Mammalia | Cycs 34 16 |
|
||
| Gm10108 35 |
|
ManyToMany | |||
| oppossum (Monodelphis domestica) |
Mammalia | -- 35 |
|
OneToMany | |
| dog (Canis familiaris) |
Mammalia | CYCS 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | LOC100363502 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 35 |
|
OneToMany | |
| chicken (Gallus gallus) |
Aves | CYC 35 |
|
OneToMany | |
| CYCS 34 |
|
||||
| lizard (Anolis carolinensis) |
Reptilia | -- 35 |
|
OneToMany | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | cycs 34 |
|
||
| MGC75709 34 |
|
||||
| zebrafish (Danio rerio) |
Actinopterygii | cycsa 35 |
|
OneToMany | |
| -- 34 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.8580 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Cyt-c-p 34 35 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP009537 34 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | cyc-2.1 34 35 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | CYC1 34 35 37 |
|
||
| CYC7 35 |
|
ManyToMany | |||
| K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0F16929g 34 |
|
||
| A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_AFR360W 34 |
|
||
| soybean (Glycine max) |
eudicotyledons | Gma.10771 34 |
|
||
| barley (Hordeum vulgare) |
Liliopsida | Hv.3294 34 |
|
||
| corn (Zea mays) |
Liliopsida | Zm.15923 34 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.4826 35 |
|
ManyToMany | |
| -- 35 |
|
ManyToMany |
- Species where no ortholog for CYCS was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for CYCS Gene
Pseudogenes.org Pseudogenes for CYCS Gene
- PGOHUM00000290428
- PGOHUM00000290694
- PGOHUM00000290978
- PGOHUM00000291040
- PGOHUM00000291061
- PGOHUM00000291755
- PGOHUM00000291871
- PGOHUM00000291934
- PGOHUM00000292037
- PGOHUM00000292098
- PGOHUM00000292730
- PGOHUM00000293220
- PGOHUM00000293265
- PGOHUM00000293476
- PGOHUM00000294224
- PGOHUM00000295952
- PGOHUM00000296009
- PGOHUM00000296143
- PGOHUM00000296571
- PGOHUM00000296590
- PGOHUM00000307806
- PGOHUM00000297330
- PGOHUM00000297925
- PGOHUM00000298041
- PGOHUM00000298714
- PGOHUM00000298939
- PGOHUM00000298942
- PGOHUM00000298946
- PGOHUM00000298989
- PGOHUM00000299263
- PGOHUM00000301769
- PGOHUM00000301890
- PGOHUM00000302422
- PGOHUM00000302906
- PGOHUM00000303201
- PGOHUM00000304392
- PGOHUM00000304681
- PGOHUM00000305373
- PGOHUM00000305401
- PGOHUM00000305818
- PGOHUM00000305486
- PGOHUM00000305665
- PGOHUM00000305786
- PGOHUM00000305790
No data available for Paralogs for CYCS Gene
Variants for CYCS Gene
| SNP ID | Clin | Chr 07 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs121918552 | Pathogenic, Thrombocytopenia 4 (THC4) [MIM:612004] | 25,123,996(-) | AGACA(A/G)GTCAG | reference, missense | |
| rs886037737 | Pathogenic | 25,123,975(-) | ACTCT(C/T)ACACA | reference, missense | |
| rs10215217 | Likely benign | 25,121,514(+) | cctgg(A/G)cgaaa | utr-variant-3-prime | |
| rs11267038 | Likely benign | 25,124,125(-) | TAGAA(G/T)TAAAT | utr-variant-5-prime | |
| rs113653188 | Likely benign | 25,118,976(+) | GAACC(-/TAT)TAAAT | utr-variant-3-prime |
Residual Variation Intolerance Score:
51.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.24;
5.36% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for CYCS Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CYCS Gene
Disorders for CYCS Gene
(39) MalaCards diseases for CYCS Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| thrombocytopenia 4 |
|
|
| autosomal thrombocytopenia with normal platelets |
|
|
| orbital granuloma |
|
|
| telangiectatic osteogenic sarcoma |
|
|
| bladder transitional cell papilloma |
|
|
Search CYCS in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
CYC_HUMAN- Thrombocytopenia 4 (THC4) [MIM:612004]: Thrombocytopenia is defined by a decrease in the number of platelets in circulating blood, resulting in the potential for increased bleeding and decreased ability for clotting. {ECO:0000269 PubMed:18345000}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Relevant External Links for CYCS
No data available for Genatlas for CYCS Gene
Publications for CYCS Gene
- Cytochrome c release upon Fas receptor activation depends on translocation of full-length bid and the induction of the mitochondrial permeability transition. (PMID: 11790791) Tafani M. … Farber J.L. (J. Biol. Chem. 2002) 2 3 22 64
- Cytochrome c in the apoptotic and antioxidant cascades. (PMID: 9515723) Skulachev V.P. (FEBS Lett. 1998) 3 4 22 64
- Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
- Absence of CYCS mutations in a large Italian cohort of patients with inherited thrombocytopenias of unknown origin. (PMID: 19172527) Savoia A. … Balduini C.L. (Platelets 2009) 3 46 64
- A mutation of human cytochrome c enhances the intrinsic apoptotic pathway but causes only thrombocytopenia. (PMID: 18345000) Morison I.M. … Ledgerwood E.C. (Nat. Genet. 2008) 3 4 64
Products for CYCS Gene
- R&D Systems Antibodies for CYCS (Cytochrome c)
- R&D Systems Proteins and Enzymes for CYCS (Cytochrome c)
- R&D Systems ELISAs, Proteome Profiler Antibody Arrays, and other biochemical assays for CYCS (Cytochrome c)
- Browse Primary Antibodies
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- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for CYCS
- Custom Assay Services
- OriGene Purified Proteins for CYCS
- Search Origene for MassSpec and Protein Over-expression Lysates for CYCS
- Origene Custom Protein Services for CYCS
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CYCS
- Browse OriGene Inhibitory RNA Products For CYCS
- OriGene qPCR primer pairs and template standards for CYCS
- OriGene qPCR primer pairs for CYCS
- OriGene CRISPR knockouts for CYCS
- OriGene ORF clones in human for CYCS
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CYCS
- GenScript: Next-day shipping cDNA ORF clone for CYCS in any vector
- GenScript Custom Purified and Recombinant Proteins Services for CYCS
- GenScript Custom Assay Services for CYCS
- GenScript Custom overexpressing Cell Line Services for CYCS
- GenScript: Design CRISPR guide RNA sequences for CYCS
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for CYCS
- Cell Signaling Technology (CST) Antibodies for CYCS (CYCS)
- Search for Antibodies & Assays
- Sino Biological Human cDNA Clone for CYCS
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Proteins
- Sino Biological Antibodies
- Sino Biological ELISA Kits and Pair Sets
- Sino Biological Cell Lysates
- Sino Biological qPCR Primers
- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for CYCS
- Novus Biologicals proteins and lysates for CYCS
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam antibodies for CYCS
- Abcam proteins for CYCS
- Abcam assays for CYCS
- Find your target
- Search knockout validated antibodies
- Browse monoclonal antibodies
- Cloud-Clone Corp. Antibodies for CYCS
- Cloud-Clone Corp. Proteins for CYCS
- Browse Assay Kits at Cloud-Clone Corp.
- Invitrogen Antibodies for CYCS
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- ApexBio compounds for CYCS
- Addgene plasmids for CYCS
- antibodies-online Antibodies for CYCS: See all 260
- antibodies-online Kits for CYCS: See all 82
- antibodies-online Proteins for CYCS: See all 96
- Search antibodies-online for peptides
- GeneTex CYCS antibody for CYCS
- GeneTex Proteins for CYCS
- ViGene Biosciences adenoviral particle packaged cDNA for CYCS gene
- ViGene Biosciences lentiviral particle packaged cDNA for CYCS gene
- ViGene Biosciences ready-to-package AAV shRNAs for CYCS gene
- Search ViGene Biosciences for CYCS
- Santa Cruz Biotechnology (SCBT) Antibodies for CYCS
- Search Santa Cruz Biotechnology (SCBT) for CYCS siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CYCS
- Search for CYCS Antibodies at ProSci
- Custom Antibody Services
- ProSci Proteins for CYCS
- Horizon Cell Lines for CYCS
- Cyagen custom Knockout/knockin (KOKI) mouse models for CYCS
- VectorBuilder custom plasmid, inducible vectors for CYCS
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CYCS
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for CYCS Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer