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CYC1 Gene

protein-coding   GIFtS: 66
GCID: GC08P145149

Cytochrome C-1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cytochrome C-11 2 3     Ubiquinol-Cytochrome-C Reductase Complex Cytochrome C1 Subunit2 3
Complex III Subunit 42 3     MC3DN62 5
Complex III Subunit IV2 3     UQCR42
Cytochrome B-C1 Complex Subunit 42 3     Cytochrome C1, Heme Protein, Mitochondrial2

External Ids:    HGNC: 25791   Entrez Gene: 15372   Ensembl: ENSG000001790917   OMIM: 1239805   UniProtKB: P085743   

Export aliases for CYC1 gene to outside databases

Previous GC identifers: GC08U990014 GC08M145286 GC08P144925 GC08P145255 GC08P145221 GC08P140425


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CYC1 Gene:
This gene encodes a subunit of the cytochrome bc1 complex, which plays an important role in the mitochondrial
respiratory chain by transferring electrons from the Rieske iron-sulfur protein to cytochrome c. Mutations in
this gene may cause mitochondrial complex III deficiency, nuclear type 6. (provided by RefSeq, Dec 2013)

GeneCards Summary for CYC1 Gene:
CYC1 (cytochrome c-1) is a protein-coding gene. Diseases associated with CYC1 include mitochondrial complex iii deficiency, nuclear type 6, and ulcerative colitis. GO annotations related to this gene include electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity and iron ion binding.

UniProtKB/Swiss-Prot: CY1_HUMAN, P08574
Function: This is the heme-containing component of the cytochrome b-c1 complex, which accepts electrons from
Rieske protein and transfers electrons to cytochrome c in the mitochondrial respiratory chain

Gene Wiki entry for CYC1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000008.11  NC_018919.2  NT_008046.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the CYC1 gene promoter:
         E2F-3a   E2F-4   E2F-5   Elk-1   E2F-2   YY1   c-Ets-1   E2F   E2F-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCYC1 promoter sequence
   Search Chromatin IP Primers for CYC1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CYC1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q24.3   Ensembl cytogenetic band:  8q24.3   HGNC cytogenetic band: 8q24

CYC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CYC1 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P145149:  view genomic region     (about GC identifiers)

Start:
145,149,930 bp from pter      End:
145,152,428 bp from pter
Size:
2,499 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CY1_HUMAN, P08574 (See protein sequence)
Recommended Name: Cytochrome c1, heme protein, mitochondrial precursor  
Size: 325 amino acids; 35422 Da
Subunit: The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and
Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6,
UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1)
Secondary accessions: Q5U062 Q6FHS7

Explore the universe of human proteins at neXtProt for CYC1: NX_P08574

Explore proteomics data for CYC1 at MOPED

Post-translational modifications: 

  • Binds 1 heme group per subunit1
  • Ubiquitination2 at Lys177
  • Modification sites at PhosphoSitePlus

  • See CYC1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001907.2  
    ENSEMBL proteins: 
     ENSP00000317159  
    Reactome Protein details: P08574

    CYC1 Human Recombinant Protein Products:

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    Novus Biologicals CYC1 Lysates
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    Cloud-Clone Corp. Proteins for CYC1

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    Cloud-Clone Corp. CLIAs for CYC1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    comIII: Mitochondrial respiratory chain complex / Complex III

    3 InterPro protein domains:
     IPR009056 Cyt_c-like_dom
     IPR002326 Cyt_c1
     IPR021157 Cyt_c1_TM_anchor_C

    Graphical View of Domain Structure for InterPro Entry P08574

    ProtoNet protein and cluster: P08574

    1 Blocks protein domain: IPB002326 Cytochrome C1 signature

    UniProtKB/Swiss-Prot: CY1_HUMAN, P08574
    Similarity: Belongs to the cytochrome c family
    Similarity: Contains 1 cytochrome c domain


    CYC1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CY1_HUMAN, P08574
    Function: This is the heme-containing component of the cytochrome b-c1 complex, which accepts electrons from
    Rieske protein and transfers electrons to cytochrome c in the mitochondrial respiratory chain

         Genatlas biochemistry entry for CYC1:
    cytochrome c-1,subunit of the mitochondrial bc1 complex III of mitochondrial respiratory chain,oxidative
    phosphorylation(OXPHOS)

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005506iron ion binding IEA--
    GO:0009055electron carrier activity ----
    GO:0020037heme binding IEA--
    GO:0045155electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity TAS2536365
         
    CYC1 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CYC1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CYC1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CYC1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CYC1

    miRNA
    Products:
        
    miRTarBase miRNAs that target CYC1:
    hsa-mir-615-3p (MIRT040321)

    Block miRNA regulation of human, mouse, rat CYC1 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate CYC1:
    hsa-miR-539 hsa-miR-32* hsa-miR-580
    SwitchGear 3'UTR luciferase reporter plasmidCYC1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CYC1
    Predesigned siRNA for gene silencing in human, mouse, rat CYC1

    Gene Editing
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    Clone
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    OriGene ORF clones in mouse, rat for CYC1
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    GenScript: all cDNA clones in your preferred vector: CYC1 (NM_001916)
    Sino Biological Human cDNA Clone for CYC1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CYC1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CYC1

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYC1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CY1_HUMAN, P08574: Mitochondrion inner membrane; Single-pass membrane protein; Intermembrane side
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    cytosol3
    extracellular1
    lysosome1
    plasma membrane1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005739mitochondrion IDA--
    GO:0005743mitochondrial inner membrane TAS--
    GO:0016021integral component of membrane IEA--
    GO:0030054cell junction ----

    CYC1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CYC1 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.0.81
    Parkinson's disease0.57
    Respiratory electron transport0.81
    Huntington's disease0.45
    The citric acid (TCA) cycle and respiratory electron transport0.71
    Non-alcoholic fatty liver disease (NAFLD)0.41
    Oxidative phosphorylation0.64
    2Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    3Alzheimer's disease
    Alzheimer's disease0.44
    4Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30
    5Mitochondrial Protein Import
    Mitochondrial Protein Import

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    2 Reactome Pathways for CYC1
        Respiratory electron transport
    Mitochondrial protein import


    Selected Kegg Pathways  (Kegg details for CYC1) (see all 7):
        Oxidative phosphorylation
    Metabolic pathways
    Cardiac muscle contraction
    Non-alcoholic fatty liver disease (NAFLD)
    Alzheimer's disease


    CYC1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CYC1: 
              Mitochondrial Energy Metabolism in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for CYC1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CYC1 (P085743 ENSP000003171594) via UniProtKB, MINT, STRING, and/or I2D (see all 201)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UQCRBP149273, ENSP000002870224I2D: score=2 STRING: ENSP00000287022
    UQCRC1P319303, ENSP000002034074I2D: score=2 STRING: ENSP00000203407
    MYCP011063, ENSP000003672074I2D: score=1 STRING: ENSP00000367207
    UQCRFS1P479853, ENSP000003063974I2D: score=10 STRING: ENSP00000306397
    MT-CYBP001563, ENSP000003545544I2D: score=5 STRING: ENSP00000354554
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0022904respiratory electron transport chain TAS--
    GO:0033762response to glucagon IEA--
    GO:0044237cellular metabolic process TAS--
    GO:0044281small molecule metabolic process TAS--

    CYC1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CYC1 (CY1)

    4 HMDB Compounds for CYC1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Heme(protoporphyrinato)iron (see all 19)14875-96-8--
    QH2CoQH2 (see all 5)56275-39-9--
    Ubiquinone Q1Coenzyme Q (see all 9)727-81-1--
    Ubiquinone Q22-(3,7-dimethyl-2,6-octadienyl)-5,6-dimethoxy-3-methyl-2,5-Cyclohexadiene-1,4-dione (see all 7)606-06-4--

    9 DrugBank Compounds for CYC1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    (5S)-3-ANILINO-5-(2,4-DIFLUOROPHENYL)-5-METHYL-1,3-OXAZOLIDINE-2,4-DIONE-- --target--10592235
    2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol-- --target--10592235
    2-NONYL-4-HYDROXYQUINOLINE N-OXIDE-- --target--10592235
    5-HEPTYL-6-HYDROXY-1,3-BENZOTHIAZOLE-4,7-DIONE-- --target--10592235
    5-n-undecyl-6-hydroxy-4,7-dioxobenzothiazole3-undecyl-2-hydroxydioxobenzothiazol (see all 4)43152-58-5target--10592235
    FAMOXADONE-- --target--10592235
    METHYL (2Z)-2-(2-{[6-(2-CYANOPHENOXY)PYRIMIDIN-4-YL]OXY}PHENYL)-3-METHOXYACRYLATE-- --target--10592235
    METHYL (2Z)-3-METHOXY-2-{2-[(E)-2-PHENYLVINYL]PHENYL}ACRYLATE-- --target--10592235
    UBIQUINONE-2-- --target--10592235

    Selected Novoseek inferred chemical compound relationships for CYC1 gene (see all 14)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    moa stilbene 90.5 1 1991466 (1)
    ubiquinol 79 2 12672829 (1), 19695092 (1)
    iron-sulfur 76 7 1318882 (1), 15917236 (1), 8688450 (1), 1848094 (1) (see all 7)
    myxothiazol 72.7 1 1851092 (1)
    ubiquinone 71.4 2 1848094 (1), 2165852 (1)
    antimycin a 67.6 3 9712733 (1), 9396723 (1), 10036166 (1)
    citrinin 56.9 3 1851092 (1)
    hydroquinone 48.8 2 1318882 (1), 12672829 (1)
    atp 16.8 3 1334457 (2), 16267049 (1)
    phospholipid 16.4 1 1848094 (1)



    CYC1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CYC1 gene: 
    NM_001916.4  

    Unigene Cluster for CYC1:

    Cytochrome c-1
    Hs.289271  [show with all ESTs]
    Unigene Representative Sequence: BF569085
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000318911(uc003zaz.4) ENST00000533444(uc003zay.3) ENST00000528618
    ENST00000525122
    miRNA
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    3 qRT-PCR Assays for microRNAs that regulate CYC1:
    hsa-miR-539 hsa-miR-32* hsa-miR-580
    SwitchGear 3'UTR luciferase reporter plasmidCYC1 3' UTR sequence
    Inhib. RNA
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CYC1
      QuantiTect SYBR Green Assays in human, mouse, rat CYC1
      QuantiFast Probe-based Assays in human, mouse, rat CYC1

    Additional mRNA sequence: 

    AK026633.1 AK225796.1 BC001006.1 BC015616.2 BC020566.1 BC024650.1 BT019798.1 CR541674.1 
    M16597.1 X06994.1 

    23 DOTS entries:

    DT.85105597  DT.219095  DT.75156262  DT.100688768  DT.100800121  DT.95272833  DT.100723054  DT.91779197 
    DT.120634145  DT.121633955  DT.95272823  DT.100800122  DT.100800125  DT.100841745  DT.120634128  DT.120634150 
    DT.91779164  DT.91779169  DT.91779196  DT.95139380  DT.95272827  DT.95272830  DT.95272831 

    Selected AceView cDNA sequences (see all 685):

    AJ707231 BM129416 AA040709 AI972923 F26065 AA453948 BE273582 BE742690 
    BU196090 CD368512 AA453445 BF821301 AA304309 BU728484 AI078786 BM824528 
    BM830030 CF145355 BG180799 BP429033 BM771578 BM692681 BM824164 AA248700 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for CYC1    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7
    SP1:                                                                        
    SP2:        -                                                               
    SP3:                          -                                             
    SP4:                                                                        


    ECgene alternative splicing isoforms for CYC1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CYC1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAATAAATT
    CYC1 Expression
    About this image


    CYC1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 18) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Adipose (Muscoskeletal System)    fully expand to see all 2 entries
             Brown adipocyte-like cells
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
     
     Neural Tube (Nervous System)
             Telencephalon
    CYC1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CYC1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.289271
        Pathway & Disease-focused RT2 Profiler PCR Arrays including CYC1: 
              Mitochondrial Energy Metabolism in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CYC1
    OriGene qSTAR qPCR primer pairs in human, mouse for CYC1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CYC1
    QuantiTect SYBR Green Assays in human, mouse, rat CYC1
    QuantiFast Probe-based Assays in human, mouse, rat CYC1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYC1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CYC1 gene from Selected species (see all 28)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cyc11 , 5 cytochrome c-11, 5 87.59(n)1
    90.77(a)1
      15 (35.74 cM)5
    664451  NM_025567.21  NP_079843.11 
     763435235 
    lizard
    (Anolis carolinensis)
    Reptilia CYC16
    cytochrome c-1
    80(a)
    1 ↔ 1
    GL343789.1(96073-106535)
    African clawed frog
    (Xenopus laevis)
    Amphibia cyc1-prov2 cytochrome c-1 76(n)    BC045127.1 
    zebrafish
    (Danio rerio)
    Actinopterygii srnyz1042 srnyz104 73.35(n)   321345  CF266205.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG145083
    CG47691
    oxidative phosphorylation electron
    transporter, more3
    CG47691
    59(a)
    (best of 2)3
    61.9(n)1
    57.84(a)1
      99A13
    386121  NM_001259708.21  NP_001246637.11 
    worm
    (Caenorhabditis elegans)
    Secernentea C54G4.83
    cyc-11
    cytochrome C1, heme protein3
    cyc-11
    49(a)3
    56.46(n)1
    51.84(a)1
      I(8031313-8032464)3
    1725821  NM_059806.31  NP_492207.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CYT1(YOR065W)4
    CYT11
    Cytochrome c1, component of the mitochondrial respiratory more4
    CYT11
    56.6(n)1
    57.96(a)1
      15(447439-448368)4
    8542311, 4  NP_014708.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G408101 AT5G40810 57.64(n)
    60(a)
      834081  NM_123446.4  NP_198897.1 
    rice
    (Oryza sativa)
    Liliopsida Os.63362 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 69.51(n)    AK069403.1 


    ENSEMBL Gene Tree for CYC1 (if available)
    TreeFam Gene Tree for CYC1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for CYC1 (see all 164)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0708474
    Mitochondrial complex III deficiency, nuclear 6 (MC3DN6)4--see VAR_0708472 W C mis40--------
    VAR_0708484
    Mitochondrial complex III deficiency, nuclear 6 (MC3DN6)4--see VAR_0708482 L F mis40--------
    rs1416385381,2
    --145148046(+) TGTTAC/GAAATA 1 -- us2k10--------
    rs1825259201,2
    --145148220(+) TCGTCA/GTTTAC 1 -- us2k10--------
    rs1851363551,2
    --145148286(+) CCGGTA/GTGTGA 1 -- us2k10--------
    rs1505292541,2
    C--145148305(+) TTCCCA/GTGTCC 1 -- us2k10--------
    rs1904254521,2
    C--145148329(+) GTTCAA/C/GTTCCC 1 -- us2k10--------
    rs1120453281,2
    C,F--145148472(+) TGGACG/TTGCTC 1 -- us2k11Minor allele frequency- T:0.50WA 2
    rs1855512431,2
    --145148622(+) GCCATC/TTGGCT 1 -- us2k10--------
    rs1903182041,2
    --145148654(+) CAGTAG/TCAGGG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CYC1 (145149930 - 145152428 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for CYC1 (see all 21):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2738050CNV Deletion23290073
    nsv891809CNV Loss21882294
    dgv7949n71CNV Loss21882294
    dgv7950n71CNV Loss21882294
    dgv906n27CNV Loss19166990
    nsv891812CNV Loss21882294
    dgv7955n71CNV Loss21882294
    nsv891807CNV Loss21882294
    dgv7954n71CNV Loss21882294
    esv29971CNV Loss17803354

    Human Gene Mutation Database (HGMD): CYC1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CYC1
    DNA2.0 Custom Variant and Variant Library Synthesis for CYC1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 123980   
    OMIM disorders: 615453  
    20 diseases for CYC1:    
    About MalaCards
    mitochondrial complex iii deficiency, nuclear type 6    ulcerative colitis    lateral sclerosis    amyotrophic lateral sclerosis
    nasopharyngitis    huntington's disease    fatty liver disease    osteosarcoma
    tonsillitis    parkinson's disease    hiv-1    liver disease
    ovarian cancer    thyroiditis    alzheimer's disease    cerebritis
    endotheliitis    malaria    prostatitis    neuronitis


    CYC1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CYC1
    Human Genome Epidemiology (HuGE) Navigator: CYC1 (4 documents)

    Export disorders for CYC1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CYC1 gene, integrated from 10 sources (see all 93):
    (articles sorted by number of sources associating them with CYC1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    2. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility &quot;hot-spot&quot;. (PubMed id 20628624)1, 4 Johnatty S.E.... . (PLoS Genet. 2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. A mitochondrial cytochrome b mutation but no mutations of nuclearly encoded subunits in ubiquinol cytochrome c reductase (complex III) deficiency. (PubMed id 10453733)1, 2 Valnot I.... Roetig A. (Hum. Genet. 1999)
    5. Structural organization of the human mitochondrial cytochrome c1 gene. (PubMed id 2536365)1, 2 Suzuki H.... Ozawa T. (J. Biol. Chem. 1989)
    6. Nucleotide sequence of a cDNA encoding the precursor to human cytochrome c1. (PubMed id 2836796)1, 2 Nishikimi M.... Ozawa T. (Nucleic Acids Res. 1988)
    7. Isolation of a cDNA clone for human cytochrome c1 from a lambda gt11 expression library. (PubMed id 3036122)1, 2 Nishikimi M.... Ozawa T. (Biochem. Biophys. Res. Commun. 1987)
    8. Assignment of the gene for the cytochrome c1 subunit of the mitochondrial cytochrome bc1 complex (CYC1) to human chromosome 8q24.3. (PubMed id 8188279)1, 9 Duncan A.M....Rozen R. (Genomics 1994)
    9. Mutations in CYC1, encoding cytochrome c1 subunit of respiratory chain complex III, cause insulin-responsive hyperglycemia. (PubMed id 23910460)1 Gaignard P....Rustin P. (Am. J. Hum. Genet. 2013)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1537 HGNC: 2579 AceView: CYC1 Ensembl:ENSG00000179091 euGenes: HUgn1537
    ECgene: CYC1 Kegg: 1537 H-InvDB: CYC1

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CYC1 Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/cyc1/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CYC1 gene:
    Search GeneIP for patents involving CYC1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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