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Aliases for CYC1 Gene

Aliases for CYC1 Gene

  • Cytochrome C-1 2 3 4
  • Ubiquinol-Cytochrome-C Reductase Complex Cytochrome C1 Subunit 3 4
  • Cytochrome B-C1 Complex Subunit 4 3 4
  • Complex III Subunit IV 3 4
  • Complex III Subunit 4 3 4
  • MC3DN6 3 6
  • Cytochrome C1, Heme Protein, Mitochondrial 3
  • UQCR4 3

External Ids for CYC1 Gene

Previous GeneCards Identifiers for CYC1 Gene

  • GC08U990014
  • GC08M145286
  • GC08P144925
  • GC08P145255
  • GC08P145221
  • GC08P145149
  • GC08P140425

Summaries for CYC1 Gene

Entrez Gene Summary for CYC1 Gene

  • This gene encodes a subunit of the cytochrome bc1 complex, which plays an important role in the mitochondrial respiratory chain by transferring electrons from the Rieske iron-sulfur protein to cytochrome c. Mutations in this gene may cause mitochondrial complex III deficiency, nuclear type 6. [provided by RefSeq, Dec 2013]

GeneCards Summary for CYC1 Gene

CYC1 (Cytochrome C-1) is a Protein Coding gene. Diseases associated with CYC1 include mitochondrial complex iii deficiency, nuclear type 6 and mitochondrial complex iii deficiency. Among its related pathways are Metabolism and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include iron ion binding and electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity.

UniProtKB/Swiss-Prot for CYC1 Gene

  • This is the heme-containing component of the cytochrome b-c1 complex, which accepts electrons from Rieske protein and transfers electrons to cytochrome c in the mitochondrial respiratory chain

Gene Wiki entry for CYC1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYC1 Gene

Genomics for CYC1 Gene

Regulatory Elements for CYC1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CYC1 Gene

Start:
144,095,027 bp from pter
End:
144,097,527 bp from pter
Size:
2,501 bases
Orientation:
Plus strand

Genomic View for CYC1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CYC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYC1 Gene

Proteins for CYC1 Gene

  • Protein details for CYC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08574-CY1_HUMAN
    Recommended name:
    Cytochrome c1, heme protein, mitochondrial
    Protein Accession:
    P08574
    Secondary Accessions:
    • Q5U062
    • Q6FHS7

    Protein attributes for CYC1 Gene

    Size:
    325 amino acids
    Molecular mass:
    35422 Da
    Quaternary structure:
    • The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1)

neXtProt entry for CYC1 Gene

Proteomics data for CYC1 Gene at MOPED

Post-translational modifications for CYC1 Gene

Other Protein References for CYC1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for CYC1 Gene

Domains for CYC1 Gene

Gene Families for CYC1 Gene

HGNC:
  • comIII :Mitochondrial respiratory chain complex / Complex III

Protein Domains for CYC1 Gene

Suggested Antigen Peptide Sequences for CYC1 Gene

Graphical View of Domain Structure for InterPro Entry

P08574

UniProtKB/Swiss-Prot:

CY1_HUMAN :
  • P08574
Domain:
  • Contains 1 cytochrome c domain.
Family:
  • Belongs to the cytochrome c family.
genes like me logo Genes that share domains with CYC1: view

Function for CYC1 Gene

Molecular function for CYC1 Gene

GENATLAS Biochemistry: cytochrome c-1,subunit of the mitochondrial bc1 complex III of mitochondrial respiratory chain,oxidative phosphorylation(OXPHOS)
UniProtKB/Swiss-Prot Function: This is the heme-containing component of the cytochrome b-c1 complex, which accepts electrons from Rieske protein and transfers electrons to cytochrome c in the mitochondrial respiratory chain

Gene Ontology (GO) - Molecular Function for CYC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005506 iron ion binding IEA --
GO:0005515 protein binding --
GO:0009055 electron carrier activity --
GO:0020037 heme binding IEA --
GO:0045155 electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity TAS 2536365
genes like me logo Genes that share ontologies with CYC1: view

miRNA for CYC1 Gene

miRTarBase miRNAs that target CYC1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CYC1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CYC1 Gene

Localization for CYC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYC1 Gene

Mitochondrion inner membrane; Single-pass membrane protein; Intermembrane side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CYC1 Gene COMPARTMENTS Subcellular localization image for CYC1 gene
Compartment Confidence
mitochondrion 5
cytosol 3
extracellular 1
lysosome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CYC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005739 mitochondrion IDA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CYC1: view

Pathways for CYC1 Gene

genes like me logo Genes that share pathways with CYC1: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for CYC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0022904 respiratory electron transport chain TAS --
GO:0033762 response to glucagon IEA --
GO:0044237 cellular metabolic process TAS --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with CYC1: view

Compounds for CYC1 Gene

(4) HMDB Compounds for CYC1 Gene

Compound Synonyms Cas Number PubMed IDs
Heme
  • (protoporphyrinato)iron
14875-96-8
QH2
  • CoQH2
56275-39-9
Ubiquinone Q1
  • Coenzyme Q
727-81-1
Ubiquinone Q2
  • 2-(3,7-dimethyl-2,6-octadienyl)-5,6-dimethoxy-3-methyl-2,5-Cyclohexadiene-1,4-dione
606-06-4

(14) Novoseek inferred chemical compound relationships for CYC1 Gene

Compound -log(P) Hits PubMed IDs
moa stilbene 90.5 1
ubiquinol 79 2
iron-sulfur 76 7
myxothiazol 72.7 1
ubiquinone 71.4 2
genes like me logo Genes that share compounds with CYC1: view

Transcripts for CYC1 Gene

mRNA/cDNA for CYC1 Gene

Unigene Clusters for CYC1 Gene

Cytochrome c-1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CYC1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CYC1 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7
SP1:
SP2: -
SP3: -
SP4:

Relevant External Links for CYC1 Gene

GeneLoc Exon Structure for
CYC1
ECgene alternative splicing isoforms for
CYC1

Expression for CYC1 Gene

mRNA expression in normal human tissues for CYC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CYC1 Gene

This gene is overexpressed in Heart - Left Ventricle (4.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CYC1 Gene

SOURCE GeneReport for Unigene cluster for CYC1 Gene Hs.289271

genes like me logo Genes that share expressions with CYC1: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for CYC1 Gene

Orthologs for CYC1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CYC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CYC1 35
  • 99.38 (n)
  • 100 (a)
CYC1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CYC1 35
  • 90.56 (n)
  • 92.92 (a)
CYC1 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CYC1 35
  • 89.33 (n)
  • 92.31 (a)
CYC1 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cyc1 35
  • 87.59 (n)
  • 90.77 (a)
Cyc1 16
Cyc1 36
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CYC1 36
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cyc1 35
  • 87.35 (n)
  • 90.74 (a)
lizard
(Anolis carolinensis)
Reptilia CYC1 36
  • 80 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia cyc1-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75973 35
MGC75973 35
  • 70.76 (n)
  • 79.42 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8431 35
zebrafish
(Danio rerio)
Actinopterygii cyc1 35
  • 67.86 (n)
  • 72.88 (a)
cyc1 36
  • 71 (a)
OneToOne
srnyz104 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006936 35
  • 65.16 (n)
  • 65.84 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG14508 36
  • 46 (a)
OneToMany
CG4769 35
  • 61.9 (n)
  • 57.84 (a)
CG4769 36
  • 55 (a)
OneToMany
CG14508 37
  • 59 (a)
CG4769 37
  • 58 (a)
worm
(Caenorhabditis elegans)
Secernentea cyc-1 35
  • 56.46 (n)
  • 51.84 (a)
cyc-1 36
  • 47 (a)
OneToOne
C54G4.8 37
  • 49 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR208W 35
  • 61.77 (n)
  • 56.73 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CYT1 35
  • 56.6 (n)
  • 57.96 (a)
CYT1 36
  • 47 (a)
OneToOne
CYT1 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F16555g 35
  • 56.73 (n)
  • 57.55 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G40810 35
  • 57.64 (n)
  • 60 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.526 35
corn
(Zea mays)
Liliopsida Zm.788 35
rice
(Oryza sativa)
Liliopsida Os.6336 35
Os01g0935700 35
  • 60.46 (n)
  • 61.04 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.28376 35
bread mold
(Neurospora crassa)
Ascomycetes NCU09816 35
  • 61.65 (n)
  • 59.35 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cyt1 35
  • 58.5 (n)
  • 56.33 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4648 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 50 (a)
OneToOne
Species with no ortholog for CYC1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for CYC1 Gene

ENSEMBL:
Gene Tree for CYC1 (if available)
TreeFam:
Gene Tree for CYC1 (if available)

Paralogs for CYC1 Gene

No data available for Paralogs for CYC1 Gene

Variants for CYC1 Gene

Sequence variations from dbSNP and Humsavar for CYC1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs1071599 -- 144,097,474(+) TAGCT(C/T)TGGGC utr-variant-3-prime
rs1126919 -- 144,097,094(+) GGCAT(C/T)TGAGC reference, missense
rs1139508 -- 144,097,270(+) GGTAA(A/C)ACCAT stop-gained, reference
rs1139509 -- 144,097,272(+) TAACA(C/G)CATAA reference, missense
rs1139510 -- 144,097,273(+) AACAC(C/G)ATAAA reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for CYC1 Gene

Variant ID Type Subtype PubMed ID
dgv7935n71 CNV Loss 21882294
dgv7940n71 CNV Loss 21882294
nsv891766 CNV Loss 21882294
dgv906n27 CNV Loss 19166990
nsv470249 CNV Loss 18288195
dgv7948n71 CNV Loss 21882294
dgv7949n71 CNV Loss 21882294
dgv7950n71 CNV Loss 21882294
nsv515809 CNV Gain+Loss 19592680
nsv470250 CNV Gain 18288195
dgv7954n71 CNV Loss 21882294
nsv466014 CNV Loss 19166990
dgv7955n71 CNV Loss 21882294
nsv891807 CNV Loss 21882294
nsv428208 CNV Gain 18775914
nsv891809 CNV Loss 21882294
esv29971 CNV Loss 17803354
dgv2263e1 CNV Complex 17122850
dgv7956n71 CNV Loss 21882294
nsv891812 CNV Loss 21882294
esv2738050 CNV Deletion 23290073

Relevant External Links for CYC1 Gene

HapMap Linkage Disequilibrium report
CYC1
Human Gene Mutation Database (HGMD)
CYC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CYC1 Gene

Disorders for CYC1 Gene

(1) OMIM Diseases for CYC1 Gene (123980)

UniProtKB/Swiss-Prot

CY1_HUMAN
  • Mitochondrial complex III deficiency, nuclear 6 (MC3DN6) [MIM:615453]: An autosomal recessive disorder caused by mitochondrial dysfunction. It is characterized by onset in early childhood of episodic acute lactic acidosis, ketoacidosis, and insulin-responsive hyperglycemia, usually associated with infection. Laboratory studies show decreased activity of mitochondrial complex III. Psychomotor development is normal. {ECO:0000269 PubMed:23910460}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for CYC1

Genetic Association Database (GAD)
CYC1
Human Genome Epidemiology (HuGE) Navigator
CYC1
genes like me logo Genes that share disorders with CYC1: view

Publications for CYC1 Gene

  1. Assignment of the gene for the cytochrome c1 subunit of the mitochondrial cytochrome bc1 complex (CYC1) to human chromosome 8q24.3. (PMID: 8188279) Duncan A.M. … Rozen R. (Genomics 1994) 3 23
  2. Structural organization of the human mitochondrial cytochrome c1 gene. (PMID: 2536365) Suzuki H. … Ozawa T. (J. Biol. Chem. 1989) 3 4
  3. Nucleotide sequence of a cDNA encoding the precursor to human cytochrome c1. (PMID: 2836796) Nishikimi M. … Ozawa T. (Nucleic Acids Res. 1988) 3 4
  4. A mitochondrial cytochrome b mutation but no mutations of nuclearly encoded subunits in ubiquinol cytochrome c reductase (complex III) deficiency. (PMID: 10453733) Valnot I. … Roetig A. (Hum. Genet. 1999) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for CYC1 Gene

Sources for CYC1 Gene

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