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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CYC1 Gene

protein-coding   GIFtS: 64
GCID: GC08P145149

Cytochrome C-1

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Cytochrome C-11 2 3     Ubiquinol-Cytochrome-C Reductase Complex Cytochrome C1 Subunit2 3
Complex III Subunit 42 3     UQCR42
Complex III Subunit IV2 3     Cytochrome C1, Heme Protein, Mitochondrial2
Cytochrome B-C1 Complex Subunit 42 3     

External Ids:    HGNC: 25791   Entrez Gene: 15372   Ensembl: ENSG000001790917   OMIM: 1239805   UniProtKB: P085743   

Export aliases for CYC1 gene to outside databases

Previous GC identifers: GC08U990014 GC08M145286 GC08P144925 GC08P145255 GC08P145221 GC08P140425


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for CYC1 Gene: 
CYC1 (cytochrome c-1) is a protein-coding gene. Diseases associated with CYC1 include ulcerative colitis, and nasopharyngitis, and among its related super-pathways are Electron Transport Chain and Metabolic pathways. GO annotations related to this gene include electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity and iron ion binding.

UniProtKB/Swiss-Prot: CY1_HUMAN, P08574
Function: This is the heme-containing component of the cytochrome b-c1 complex, which accepts electrons from
Rieske protein and transfers electrons to cytochrome c in the mitochondrial respiratory chain

Gene Wiki entry for CYC1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.2  NT_008046.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CYC1 gene promoter:
         E2F-3a   E2F-4   E2F-5   Elk-1   E2F-2   YY1   c-Ets-1   E2F   E2F-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCYC1 promoter sequence
   Search SABiosciences Chromatin IP Primers for CYC1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CYC1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q24.3   Ensembl cytogenetic band:  8q24.3   HGNC cytogenetic band: 8q24

CYC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CYC1 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P145149:  view genomic region     (about GC identifiers)

Start:
145,149,930 bp from pter      End:
145,152,428 bp from pter
Size:
2,499 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CY1_HUMAN, P08574 (See protein sequence)
Recommended Name: Cytochrome c1, heme protein, mitochondrial precursor  
Size: 325 amino acids; 35422 Da
Subunit: The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and
Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6,
UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1)
Subcellular location: Mitochondrion inner membrane; Single-pass membrane protein; Intermembrane side
Secondary accessions: Q5U062 Q6FHS7

Explore the universe of human proteins at neXtProt for CYC1: NX_P08574

Explore proteomics data for CYC1 at MOPED 

Post-translational modifications:

  • UniProtKB: Binds 1 heme group per subunit
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P08574

  • CYC1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CYC1 Protein Expression
    REFSEQ proteins: NP_001907.2  
    ENSEMBL proteins: 
     ENSP00000317159  
    Reactome Protein details: P08574
    Human Recombinant Protein Products for CYC1: 
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    Cloud-Clone Corp. Proteins for CYC1 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005739mitochondrion IDA--
    GO:0005743mitochondrial inner membrane TAS--
    GO:0016021integral to membrane IEA--
    GO:0030054cell junction IDA--

    CYC1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    comIII: Mitochondrial respiratory chain complex / Complex III

    3 InterPro protein domains:
     IPR009056 Cyt_c_dom
     IPR002326 Cyt_c1
     IPR021157 Cyt_c1_TM_anchor_C

    Graphical View of Domain Structure for InterPro Entry P08574

    ProtoNet protein and cluster: P08574

    1 Blocks protein domain: IPB002326 Cytochrome C1 signature

    UniProtKB/Swiss-Prot: CY1_HUMAN, P08574
    Similarity: Belongs to the cytochrome c family
    Similarity: Contains 1 cytochrome c domain


    CYC1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CY1_HUMAN, P08574
    Function: This is the heme-containing component of the cytochrome b-c1 complex, which accepts electrons from
    Rieske protein and transfers electrons to cytochrome c in the mitochondrial respiratory chain

         Genatlas biochemistry entry for CYC1:
    cytochrome c-1,subunit of the mitochondrial bc1 complex III of mitochondrial respiratory chain,oxidative
    phosphorylation(OXPHOS)

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005506iron ion binding IEA--
    GO:0009055electron carrier activity ----
    GO:0020037heme binding IEA--
    GO:0045155electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity TAS2536365
         
    CYC1 for ontologies           About GeneDecksing


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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CYC1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.0.81
    Parkinson's disease0.61
    Respiratory electron transport0.81
    Huntington's disease0.47
    The citric acid (TCA) cycle and respiratory electron transport0.72
    Alzheimer's disease0.46
    Oxidative phosphorylation0.64
    Non-alcoholic fatty liver disease (NAFLD)0.41
    2Metabolism
    Metabolism0.40
    Metabolic pathways0.40
    3Asparagine N-linked glycosylation
    Metabolism of proteins0.35
    4Mitochondrial Protein Import
    Mitochondrial Protein Import
    5Cardiac muscle contraction
    Cardiac muscle contraction

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5/6        Reactome Pathways for CYC1 (see all 6)
        Respiratory electron transport
    Metabolism
    Mitochondrial Protein Import
    Metabolism of proteins
    Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.


    5/7         Kegg Pathways  (Kegg details for CYC1) (see all 7):
        Oxidative phosphorylation
    Metabolic pathways
    Cardiac muscle contraction
    Non-alcoholic fatty liver disease (NAFLD)
    Alzheimer's disease


    CYC1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CYC1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/165 Interacting proteins for CYC1 (P085743 ENSP000003171594) via UniProtKB, MINT, STRING, and/or I2D (see all 165)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UQCRBP149273, ENSP000002870224I2D: score=2 STRING: ENSP00000287022
    UQCRC1P319303, ENSP000002034074I2D: score=2 STRING: ENSP00000203407
    ALADP137163, ENSP000003862844I2D: score=1 STRING: ENSP00000386284
    GTF2H2CQ6P1K83I2D: score=1 
    GTF2H2DQ6P1K83I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0022904respiratory electron transport chain TAS--
    GO:0044237cellular metabolic process TAS--
    GO:0044281small molecule metabolic process TAS--

    CYC1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CYC1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CYC1 (CY1)

    4 HMDB Compounds for CYC1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Heme(protoporphyrinato)iron (see all 19)14875-96-8--
    QH2CoQH2 (see all 5)56275-39-9--
    Ubiquinone Q1Coenzyme Q (see all 9)727-81-1--
    Ubiquinone Q22-(3,7-dimethyl-2,6-octadienyl)-5,6-dimethoxy-3-methyl-2,5-Cyclohexadiene-1,4-dione (see all 7)606-06-4--

    9 DrugBank Compounds for CYC1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    (5S)-3-ANILINO-5-(2,4-DIFLUOROPHENYL)-5-METHYL-1,3-OXAZOLIDINE-2,4-DIONE-- --target--10592235
    2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol-- --target--10592235
    2-NONYL-4-HYDROXYQUINOLINE N-OXIDE-- --target--10592235
    5-HEPTYL-6-HYDROXY-1,3-BENZOTHIAZOLE-4,7-DIONE-- --target--10592235
    5-n-undecyl-6-hydroxy-4,7-dioxobenzothiazole3-undecyl-2-hydroxydioxobenzothiazol (see all 4)43152-58-5target--10592235
    FAMOXADONE-- --target--10592235
    METHYL (2Z)-2-(2-{[6-(2-CYANOPHENOXY)PYRIMIDIN-4-YL]OXY}PHENYL)-3-METHOXYACRYLATE-- --target--10592235
    METHYL (2Z)-3-METHOXY-2-{2-[(E)-2-PHENYLVINYL]PHENYL}ACRYLATE-- --target--10592235
    UBIQUINONE-2-- --target--10592235

    10/14 Novoseek inferred chemical compound relationships for CYC1 gene (see all 14)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    moa stilbene 90.5 1 1991466 (1)
    ubiquinol 79 2 12672829 (1), 19695092 (1)
    iron-sulfur 76 7 1318882 (1), 15917236 (1), 8688450 (1), 1848094 (1) (see all 7)
    myxothiazol 72.7 1 1851092 (1)
    ubiquinone 71.4 2 1848094 (1), 2165852 (1)
    antimycin a 67.6 3 9712733 (1), 9396723 (1), 10036166 (1)
    citrinin 56.9 3 1851092 (1)
    hydroquinone 48.8 2 1318882 (1), 12672829 (1)
    atp 16.8 3 1334457 (2), 16267049 (1)
    phospholipid 16.4 1 1848094 (1)

    Search CenterWatch for drugs/clinical trials and news about CYC1 / CY1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CYC1 gene: 
    NM_001916.3  

    Unigene Cluster for CYC1:

    Cytochrome c-1
    Hs.289271  [show with all ESTs]
    Unigene Representative Sequence: BF569085
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000318911(uc003zaz.4) ENST00000533444(uc003zay.3) ENST00000528618
    ENST00000525122
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    AK026633.1 AK225796.1 BC001006.1 BC015616.2 BC020566.1 BC024650.1 BT019798.1 CR541674.1 
    M16597.1 X06994.1 

    23 DOTS entries:

    DT.85105597  DT.219095  DT.75156262  DT.100688768  DT.100800121  DT.95272833  DT.100723054  DT.91779197 
    DT.120634145  DT.121633955  DT.95272823  DT.100800122  DT.100800125  DT.100841745  DT.120634128  DT.120634150 
    DT.91779164  DT.91779169  DT.91779196  DT.95139380  DT.95272827  DT.95272830  DT.95272831 

    24/685 AceView cDNA sequences (see all 685):

    CA306243 BQ421140 BE296554 AJ707231 BM129416 AA040709 AI972923 F26065 
    AA453948 BE273582 BE742690 BU196090 CD368512 AA453445 BF821301 AA304309 
    BU728484 AI078786 BM824528 BM830030 CF145355 BG180799 BP429033 BM771578 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for CYC1    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7
    SP1:                                                                        
    SP2:        -                                                               
    SP3:                          -                                             
    SP4:                                                                        


    ECgene alternative splicing isoforms for CYC1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CYC1 expression in normal human tissues (normalized intensities)      CYC1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAATAAATT
    CYC1 Expression
    About this image


    CYC1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/35 selected tissues (see all 35) fully expand
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Cerebral Cortex
             brain/midbrain   
     
     Uterus (Reproductive System)    fully expand to see all 5 entries
             uterus, post-menopause ; glandular cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Tonsil (Hematopoietic System)    fully expand to see all 3 entries
             tonsil ; squamous epithelial cells   

    See CYC1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CYC1

    SOURCE GeneReport for Unigene cluster: Hs.289271
        SABiosciences Expression via Pathway-Focused PCR Arrays including CYC1: 
              Mitochondrial Energy Metabolism in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CYC1 gene from 9/27 species (see all 27)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cyc11 , 5 cytochrome c-11, 5 87.59(n)1
    90.77(a)1
      15 (35.74 cM)5
    664451  NM_025567.21  NP_079843.11 
     763435235 
    lizard
    (Anolis carolinensis)
    Reptilia CYC16
    Uncharacterized protein
    80(a)
    1 ↔ 1
    GL343789.1(96073-106535)
    African clawed frog
    (Xenopus laevis)
    Amphibia cyc1-prov2 cytochrome c-1 76(n)    BC045127.1 
    zebrafish
    (Danio rerio)
    Actinopterygii srnyz1042 srnyz104 73.35(n)   321345  CF266205.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG145083
    CG47691
    oxidative phosphorylation electron
    transporter, more3
    CG47691
    59(a)
    (best of 2)3
    62.11(n)1
    58.25(a)1
      99A13
    386121  NM_139701.11  NP_647958.11 
    worm
    (Caenorhabditis elegans)
    Secernentea C54G4.83
    cyc-11
    cytochrome C1, heme protein3
    Protein CYC-11
    49(a)3
    54.91(n)1
    51.27(a)1
      I(8031313-8032464)3
    1725821  NM_059806.21  NP_492207.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CYT1(YOR065W)4
    CYT11
    Cytochrome c1, component of the mitochondrial respiratory more4
    Cyt1p1
    53.84(n)1
    54.68(a)1
      15(447439-448368)4
    8542311, 4  NP_014708.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G408101 ubiquinol-cytochrome c reductase cytochrome c1 subunit 55.16(n)
    56.12(a)
      834081  NM_123446.4  NP_198897.1 
    rice
    (Oryza sativa)
    Liliopsida Os.63362 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 69.51(n)    AK069403.1 


    ENSEMBL Gene Tree for CYC1 (if available)
    TreeFam Gene Tree for CYC1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/162 SNPs in CYC1 are shown (see all 162)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0251634
    ----see VAR_0251632 M V mis40--------
    VAR_0136314
    ----see VAR_0136312 L V mis40--------
    rs1416385381,2
    --145148046(+) TGTTAC/GAAATA 1 -- us2k10--------
    rs1825259201,2
    --145148220(+) TCGTCA/GTTTAC 1 -- us2k10--------
    rs1851363551,2
    --145148286(+) CCGGTA/GTGTGA 1 -- us2k10--------
    rs1505292541,2
    C--145148305(+) TTCCCA/GTGTCC 1 -- us2k10--------
    rs1904254521,2
    C--145148329(+) GTTCAA/C/GTTCCC 1 -- us2k10--------
    rs1120453281,2
    C,F--145148472(+) TGGACG/TTGCTC 1 -- us2k11Minor allele frequency- T:0.50WA 2
    rs1855512431,2
    --145148622(+) GCCATC/TTGGCT 1 -- us2k10--------
    rs1903182041,2
    --145148654(+) CAGTAG/TCAGGG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CYC1 (145149930 - 145152428 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/21 variations for CYC1 (see all 21):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2738050CNV Deletion23290073
    nsv891809CNV Loss21882294
    dgv7949n71CNV Loss21882294
    dgv7950n71CNV Loss21882294
    dgv906n27CNV Loss19166990
    nsv891812CNV Loss21882294
    dgv7955n71CNV Loss21882294
    nsv891807CNV Loss21882294
    dgv7954n71CNV Loss21882294
    esv29971CNV Loss17803354

    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for CYC1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 123980    OMIM disorders: --

    13 diseases for CYC1:    About MalaCards
    ulcerative colitis    nasopharyngitis    huntington's disease    amyotrophic lateral sclerosis
    lateral sclerosis    osteosarcoma    parkinson's disease    ovarian cancer
    thyroiditis    prostatitis    endotheliitis    alzheimer's disease
    neuronitis


    CYC1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): CYC1
    Human Genome Epidemiology (HuGE) Navigator: CYC1 (4 documents)

    Export disorders for CYC1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CYC1 gene, integrated from 9 sources (see all 91):
    (articles sorted by number of sources associating them with CYC1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
    2. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility 'hot-spot'. (PubMed id 20628624)1, 4 Johnatty S.E.... . (2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. A mitochondrial cytochrome b mutation but no mutations of nuclearly encoded subunits in ubiquinol cytochrome c reductase (complex III) deficiency. (PubMed id 10453733)1, 2 Valnot I.... Roetig A. (1999)
    5. Structural organization of the human mitochondrial cytochrome c1 gene. (PubMed id 2536365)1, 2 Suzuki H.... Ozawa T. (1989)
    6. Nucleotide sequence of a cDNA encoding the precursor to human cytochrome c1. (PubMed id 2836796)1, 2 Nishikimi M.... Ozawa T. (1988)
    7. Isolation of a cDNA clone for human cytochrome c1 from a lambda gt11 expression library. (PubMed id 3036122)1, 2 Nishikimi M.... Ozawa T. (1987)
    8. Assignment of the gene for the cytochrome c1 subunit of the mitochondrial cytochrome bc1 complex (CYC1) to human chromosome 8q24.3. (PubMed id 8188279)1, 9 Duncan A.M....Rozen R. (1994)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    10. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1537 HGNC: 2579 AceView: CYC1 Ensembl:ENSG00000179091 euGenes: HUgn1537
    ECgene: CYC1 Kegg: 1537 H-InvDB: CYC1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CYC1 Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/cyc1/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CYC1 gene:
    Search GeneIP for patents involving CYC1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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