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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CYBRD1 Gene

protein-coding   GIFtS: 57
GCID: GC02P172378

cytochrome b reductase 1
 Explore 6 diseases affiliated with
CYBRD1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CYBRD1    

Aliases
for CYBRD1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Cytochrome B Reductase 11 2     Ferric-Chelate Reductase 32 3
DCYTB1 2 3     FLJ234621
FRRS31 2 3     EC 1.-.-.-3
Duodenal Cytochrome B2 3     

External Ids:    HGNC: 207971   Entrez Gene: 799012   Ensembl: ENSG000000719677   OMIM: 6057455   UniProtKB: Q53TN43   

Export aliases for CYBRD1 gene to outside databases

Previous GC identifers: GC02P172342 GC02P172581 GC02P172204 GC02P172087 GC02P164264


Summaries
for CYBRD1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CYBRD1:
This gene is a member of the cytochrome b(561) family that encodes an iron-regulated protein. It highly expressed in
the duodenal brush border membrane. It has ferric reductase activity and is believed to play a physiological role in
dietary iron absorption. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CYBR1_HUMAN, Q53TN4
Function: Ferric-chelate reductase that reduces Fe(3+) to Fe(2+). Present at the brush border of duodenal enterocytes
where it probably reduces dietary Fe(3+) thereby facilitating its transport into the mucosal cells. Uses ascorbate as
electron donor. May be involved in extracellular ascorbate recycling in erythrocyte membranes. May also act as a
ferrireductase in airway epithelial cells




Genomic Views
for CYBRD1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_005403.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CYBRD1 gene promoter:
         Pax-5   Tal-1   Brachyury   p300   HSF1 (long)   RelA   E47   CP2   HSF1short   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CYBRD1 promoter sequence
   Search SABiosciences Chromatin IP Primers for CYBRD1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CYBRD1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q31.1   Ensembl cytogenetic band:  2q31.1   HGNC cytogenetic band: 2q31

CYBRD1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CYBRD1 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P172378:  view genomic region     (about GC identifiers)

Start:
 172,378,757 bp from pter      End:
 172,414,643 bp from pter
Size:
 35,887 bases      Orientation:
 plus strand

Proteins
for CYBRD1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CYBR1_HUMAN, Q53TN4 (See protein sequence)
Recommended Name: Cytochrome b reductase 1  
Size: 286 amino acids; 31641 Da
Cofactor: Binds 2 heme groups non-covalently (By similarity)
Subcellular location: Membrane; Multi-pass membrane protein
Sequence caution: Sequence=CAG29366.1; Type=Erroneous gene model prediction; Sequence=CAG29367.1; Type=Erroneous gene
model prediction;
Secondary accessions: B2RE79 B4DWD7 Q6KC16 Q6KC17 Q6P147 Q6ZR51 Q9H0Q8 Q9H5G5
Alternative splicing: 3 isoforms:  Q53TN4-1   Q53TN4-2   Q53TN4-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CYBRD1: NX_Q53TN4

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q53TN4

    • CYBRD1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001120855.1  NP_001243838.1  NP_079119.3  

    ENSEMBL proteins: 
     ENSP00000386739   ENSP00000319141   ENSP00000364401   ENSP00000402242  
    Reactome Protein details: Q53TN4
    Human Recombinant Protein Products: 
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    Novus Biologicals CYBRD1 Protein
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    Uscn Proteins for CYBRD1

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral to membrane IEA--
    GO:0031526brush border membrane IEA--


    CYBRD1 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for CYBRD1

    Protein Domains /
    Families
    for CYBRD1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CYBRD1 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR004877 Cyt_b561_euk
     IPR006593 Cyt_b561/ferric_Rdtase_TM

    Graphical View of Domain Structure for InterPro Entry Q53TN4

    ProtoNet protein and cluster: Q53TN4

    1 Blocks protein family: IPB006593 Cytochrome b561 / ferric reductase transmembrane

    UniProtKB/Swiss-Prot: CYBR1_HUMAN, Q53TN4
    Similarity: Contains 1 cytochrome b561 domain


    Function
    for CYBRD1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CYBR1_HUMAN, Q53TN4
    Function: Ferric-chelate reductase that reduces Fe(3+) to Fe(2+). Present at the brush border of duodenal enterocytes
    where it probably reduces dietary Fe(3+) thereby facilitating its transport into the mucosal cells. Uses ascorbate as
    electron donor. May be involved in extracellular ascorbate recycling in erythrocyte membranes. May also act as a
    ferrireductase in airway epithelial cells
    Induction: By iron deficiency (at protein level)

    Enzyme Number (IUBMB): EC 1.-.-.-1

    miRNA
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    hsa-miR-579 hsa-miR-26a-2* hsa-miR-520e hsa-miR-106a hsa-miR-3074-3p hsa-miR-374a hsa-miR-371-5p hsa-miR-629*
    SwitchGear 3'UTR luciferase reporter plasmid: CYBRD1 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000293ferric-chelate reductase activity IDA14499595
    GO:0016722oxidoreductase activity, oxidizing metal ions TAS--
    GO:0046872metal ion binding IEA--


    CYBRD1 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for CYBRD1:
     Decreased viability with pacli 

    Animal Models:
         Mouse knock-out Cybrd1tm1Nca for CYBRD1
         2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Cybrd1):
     homeostasis/metabolism  liver/biliary system 

    CYBRD1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for CYBRD1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Mineral absorption
    		Mineral absorption1.00
    2Insulin receptor recycling
    		Iron uptake and transport0.56
    3SLC-mediated transmembrane transport
    		Transmembrane transport of small molecules0.50

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    2        Reactome Pathways for CYBRD1
        Transmembrane transport of small molecules
    Iron uptake and transport


    1         Kegg Pathway  (Kegg details for CYBRD1):
        Mineral absorption


    CYBRD1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CYBRD1

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    3 Interacting proteins for CYBRD1 (Q53TN43 ENSP000003191414) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NAPBQ9H1153I2D: score=1 
    STX4Q128463I2D: score=1 
    SLC11A2ENSP000002620524STRING: ENSP00000262052
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006879cellular iron ion homeostasis TAS--
    GO:0010039response to iron ion IEA--
    GO:0022900electron transport chain IEA--
    GO:0055085transmembrane transport TAS--


    CYBRD1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CYBRD1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CYBRD1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CYBRD1

    2 HMDB Compounds for CYBRD1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Heme(protoporphyrinato)iron (see all 19)14875-96-8--
    IronArmco iron (see all 19)7439-89-6--
    3 Novoseek chemical compound relationships for CYBRD1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    iron 62.3 38 17087784 (7), 16137899 (4), 12949720 (4), 18492824 (3) (see all 10)
    fe3+ 53.1 1 12196176 (1)
    ascorbic acid 51 5 20184953 (2), 18194661 (2)

    Search CenterWatch for drugs/clinical trials and news about CYBRD1 / CYBR1 

    Transcripts
    for CYBRD1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CYBRD1 gene (3 alternative transcripts): 
    NM_001127383.1  NM_001256909.1  NM_024843.3  

    Unigene Cluster for CYBRD1:

    Cytochrome b reductase 1
    Hs.221941  [show with all ESTs]
    Unigene Representative Sequence: NM_024843
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000409484 ENST00000468308 ENST00000321348(uc002ugy.4 uc002ugz.4)
    ENST00000375252 ENST00000474182 ENST00000494587 ENST00000445146

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    8/75 QIAGEN miScript miRNA Assays for microRNAs that regulate CYBRD1 (see all 75):
    hsa-miR-579 hsa-miR-26a-2* hsa-miR-520e hsa-miR-106a hsa-miR-3074-3p hsa-miR-374a hsa-miR-371-5p hsa-miR-629*
    SwitchGear 3'UTR luciferase reporter plasmid: CYBRD1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CYBRD1 (see all 7)
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    Clone
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    Additional cDNA sequence: 

    AK026654.1 AK027115.1 AK128495.1 AK225459.1 AK291731.1 AK301485.1 AK316588.1 AL136693.1 
    AL834483.1 BC016900.2 BC065290.1 

    9 DOTS entries:

    DT.445304  DT.99977849  DT.99950803  DT.100825490  DT.91880715  DT.91741788  DT.100037684  DT.100825493 
    DT.97833180 

    24/329 AceView cDNA sequences (see all 329):

    BQ029515 BC016900 AA947179 CA455101 BM981066 BM723590 R09234 CA424915 
    AA693926 CD677258 C00322 BM721523 CR601938 AA442294 AA631537 W42866 
    CA396900 AL597707 BQ001790 AA284834 AI383016 BQ030018 CA393101 BP341104 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for CYBRD1    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d
    SP1:                    -           -     -                                 
    SP2:                                -     -                                 
    SP3:                    -                                                   
    SP4:                    -     -     -     -                                 
    SP5:                                                                        


    ECgene alternative splicing isoforms for CYBRD1

    Expression
    for CYBRD1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CYBRD1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TAAGCTGTGC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    CYBRD1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BrainBlood Brain BarrierPostnatal Endothelial CellsBlood Brain Barrier, Endothelium
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See CYBRD1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CYBRD1

    SOURCE GeneReport for Unigene cluster: Hs.221941

    UniProtKB/Swiss-Prot: CYBR1_HUMAN, Q53TN4
    Tissue specificity: Present in erythrocyte membranes (at protein level). Also expressed in respiratory epithelium

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    In Situ
    Assay Products:     
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    Orthologs
    for CYBRD1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CYBRD1 gene from 8/23 species (see all 23)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves CYBRD11 cytochrome b reductase 1 69.36(n)
    65.47(a)    		   424152  XM_421999.3  XP_421999.3 
    lizard
    (Anolis carolinensis)    		 Reptilia CYBRD16
    		 --
    		 65(a)
    		 1 ↔ 1
    		 GL343353.1(1072010-1094531)
    African clawed frog
    (Xenopus laevis)    		 Amphibia BM179782.12   -- 77.55(n)    BM179782.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii cybrd11 cytochrome b reductase 1 62.29(n)
    63.56(a)    		   552960  NM_001020500.1  NP_001018336.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG12751 CG1275 51.54(n)
    44.44(a)    		   38286  NM_139446.3  NP_647703.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea CELE_F55H2.51 Protein F55H2.5 43.89(n)
    32.13(a)    		   186343  NM_066694.1  NP_499095.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons ACYB-21 cytochrome b561/ferric reductase transmembrane family more 47.93(n)
    36.82(a)    		   828662  NM_118689.3  NP_567723.1 
    rice
    (Oryza sativa)    		 Liliopsida Os04g05335001 hypothetical protein 46.09(n)
    36.73(a)    		   4336503  NM_001059945.1  NP_001053410.1 


    ENSEMBL Gene Tree for CYBRD1 (if available)
    TreeFam Gene Tree for CYBRD1 (if available) 

    Paralogs
    for CYBRD1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CYBRD1 gene
    CYBASC32  CYB5612  
    2 SIMAP similar genes for CYBRD1 using alignment to 2 protein entries:     CYBR1_HUMAN (see all proteins):
    CYBASC3    CYB561

    CYBRD1 for paralogs           About GeneDecksing



    Genomic Variants
    for CYBRD1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: CYBR1_HUMAN, Q53TN4
    Polymorphism: Genetic variations in CYBRD1 may act as modifier of iron overload expression and account for the variance
    observed in serum ferritin levels in patients with hereditary hemochromatosis


    10/762 NCBI SNPs in CYBRD1 are shown (see all 762)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 2 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs750493621,2
    		F,--172376769(+) CAAGAC/TGGCAA 1 -- us2k11Minor allele frequency- T:0.22WA 118
    rs38065621,2
    		C,F,H,--172376785(+) CAATAT/CAGCAA 1 -- us2k125Minor allele frequency- C:0.18EA NA NS WA CSA 3781
    rs1490784401,2
    		--172376807(+) GAGATA/GAGCTA 1 -- us2k10--------
    rs1431936071,2
    		--172376824(+) AGGGCG/TAGAAG 1 -- us2k10--------
    rs1884065481,2
    		--172376921(+) GTCCAA/GTGGAG 3 -- us2k10--------
    rs38065631,2
    		C,F,H,--172376933(+) AGGGTG/AAGGAT 3 -- us2k125Minor allele frequency- A:0.18EA NS NA WA CSA 3466
    rs728843171,2
    		C,--172376961(+) AGGGAG/ACAAGC 3 -- us2k13Minor allele frequency- A:0.07NA EA 242
    rs38065641,2
    		C,F,A,--172376963(+) GGAGCA/GAGCTT 3 -- us2k113Minor allele frequency- G:0.14EA NA WA CSA 1688
    rs38065651,2
    		C,F,A,H,--172377000(+) CAAATT/CGGTTT 3 -- us2k116Minor allele frequency- C:0.15EA NS NA WA CSA 2034
    rs1931929671,2
    		--172377047(+) TAAACA/GGCAAG 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for CYBRD1 (172378757 - 172414643 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for CYBRD1: --
    Human Gene Mutation Database (HGMD): CYBRD1

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for CYBRD1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CYBRD1 for disorders           About GeneDecksing

    OMIM gene information: 605745    OMIM disorders: --

    6 diseases for CYBRD1:    About MalaCards
    duodenitis    iron overload    iron deficiency anemia    hemochromatosis
    siderosis    anemia

    3 diseases from the University of Copenhagen DISEASES database for CYBRD1:
    Hemochromatosis     Siderosis     Iron deficiency anemia

    4 Novoseek disease relationships for CYBRD1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hereditary hemochromatosis 80.7 1 16137899 (1)
    iron deficiency 68.5 9 17087784 (3), 12949720 (3), 16137899 (2)
    iron overload 60.1 3 15338274 (2), 14618243 (1)
    hemochromatosis 57.3 4 12949720 (3)

    Genetic Association Database (GAD): CYBRD1
    Human Genome Epidemiology (HuGE) Navigator: CYBRD1 (5 documents)

    Export disorders for CYBRD1 gene to outside databases

    Publications
    for CYBRD1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CYBRD1 gene, integrated from 9 sources (see all 38):
    (articles sorted by number of sources associating them with CYBRD1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Analysis of genes implicated in iron regulation in individuals presenting with primary iron overload. (PubMed id 15338274)1, 2, 4, 9 Zaahl M.G.... Robson K.J.H. (2004)
    2. Duodenal cytochrome b and hephaestin expression in patients with iron deficiency and hemochromatosis. (PubMed id 12949720)1, 2, 9 Zoller H....Weiss G. (2003)
    3. A novel association between a SNP in CYBRD1 and serum ferritin levels in a cohort study of HFE hereditary haemochromatosis. (PubMed id 19673882)1, 2 Constantine C.C....Gurrin L.C. (2009)
    4. Human erythrocyte membranes contain a cytochrome b561 that may be involved in extracellular ascorbate recycling. (PubMed id 17068337)1, 2 Su D.... Asard H. (2006)
    5. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
    6. An iron-regulated ferric reductase associated with the absorption of dietary iron. (PubMed id 11230685)1, 3 McKie A.T....Simpson R.J. (2001)
    7. Functional characterization of human duodenal cytochrome b (Cybrd1): Redox properties in relation to iron and ascorbate metabolism. (PubMed id 18194661)1, 9 Oakhill J.S....McKie A.T. (2008)
    8. Immunolocalization of duodenal cytochrome B: a relationship with circulating markers of iron status. (PubMed id 17087784)2, 9 Li A.C....Powell J.J. (2006)
    9. Duodenal cytochrome B expression stimulates iron uptake by human intestinal epithelial cells. (PubMed id 18492824)1, 9 Latunde-Dada G.O....McKie A.T. (2008)
    10. Examination of genetic polymorphisms in newborns for signatures of sex-specific prenatal selection. (PubMed id 20587610)1 Ucisik-Akkaya E....Tevfik Dorak M. (2010)

    External Searches for CYBRD1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
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    Genome Databases showing CYBRD1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 79901 HGNC: 20797 AceView: CYBRD1 Ensembl:ENSG00000071967 euGenes: HUgn79901
    ECgene: CYBRD1 Kegg: 79901 H-InvDB: CYBRD1

    Other Databases showing CYBRD1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CYBRD1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CYBRD1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for CYBRD1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CYBRD1 gene:
    Search GeneIP for patents involving CYBRD1

    GeneCards and IP:
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