Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



CYBRD1 Gene

protein-coding   GIFtS: 61
GCID: GC02P172378

Cytochrome B Reductase 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Cytochrome B Reductase 11 2     Cytochrome B561 Family1
Ferric-Chelate Reductase 31 2 3     Member A21
Duodenal Cytochrome B2 3     CYB561A22
DCYTB2 3     Cytochrome B561 Family, Member A22
FRRS32 3     EC 1.-.-.-3

External Ids:    HGNC: 207971   Entrez Gene: 799012   Ensembl: ENSG000000719677   OMIM: 6057455   UniProtKB: Q53TN43   

Export aliases for CYBRD1 gene to outside databases

Previous GC identifers: GC02P172342 GC02P172581 GC02P172204 GC02P172087 GC02P164264


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for CYBRD1 Gene:
This gene is a member of the cytochrome b(561) family that encodes an iron-regulated protein. It highly expressed
in the duodenal brush border membrane. It has ferric reductase activity and is believed to play a physiological
role in dietary iron absorption. (provided by RefSeq, Jul 2008)

GeneCards Summary for CYBRD1 Gene:
CYBRD1 (cytochrome b reductase 1) is a protein-coding gene. Diseases associated with CYBRD1 include duodenitis, and siderosis. GO annotations related to this gene include oxidoreductase activity, oxidizing metal ions and ferric-chelate reductase activity. An important paralog of this gene is CYB561.

UniProtKB/Swiss-Prot: CYBR1_HUMAN, Q53TN4
Function: Ferric-chelate reductase that reduces Fe(3+) to Fe(2+). Present at the brush border of duodenal
enterocytes where it probably reduces dietary Fe(3+) thereby facilitating its transport into the mucosal cells.
Uses ascorbate as electron donor. May be involved in extracellular ascorbate recycling in erythrocyte membranes.
May also act as a ferrireductase in airway epithelial cells




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000002.12  NC_018913.2  NT_005403.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the CYBRD1 gene promoter:
         Pax-5   Tal-1   Brachyury   p300   HSF1 (long)   RelA   E47   CP2   HSF1short   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCYBRD1 promoter sequence
   Search Chromatin IP Primers for CYBRD1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CYBRD1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q31.1   Ensembl cytogenetic band:  2q31.1   HGNC cytogenetic band: 2q31

CYBRD1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CYBRD1 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P172378:  view genomic region     (about GC identifiers)

Start:
172,378,757 bp from pter      End:
172,414,643 bp from pter
Size:
35,887 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: CYBR1_HUMAN, Q53TN4 (See protein sequence)
Recommended Name: Cytochrome b reductase 1  
Size: 286 amino acids; 31641 Da
Cofactor: Binds 2 heme groups non-covalently (By similarity)
Sequence caution: Sequence=CAG29366.1; Type=Erroneous gene model prediction; Sequence=CAG29367.1; Type=Erroneous
gene model prediction;
Secondary accessions: B2RE79 B4DWD7 Q6KC16 Q6KC17 Q6P147 Q6ZR51 Q9H0Q8 Q9H5G5
Alternative splicing: 3 isoforms:  Q53TN4-1   Q53TN4-2   Q53TN4-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CYBRD1: NX_Q53TN4

Explore proteomics data for CYBRD1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn231
  • Modification sites at PhosphoSitePlus

  • See CYBRD1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001120855.1  NP_001243838.1  NP_079119.3  

    ENSEMBL proteins: 
     ENSP00000386739   ENSP00000319141   ENSP00000364401   ENSP00000402242  
    Reactome Protein details: Q53TN4

    CYBRD1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for CYBRD1
    OriGene Protein Over-expression Lysate for CYBRD1
    OriGene MassSpec for CYBRD1
    OriGene Custom Protein Services for CYBRD1
    GenScript Custom Purified and Recombinant Proteins Services for CYBRD1
    Novus Biologicals CYBRD1 Protein
    Novus Biologicals CYBRD1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CYBRD1

    CYBRD1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for CYBRD1
    OriGene Custom Antibody Services for CYBRD1
    Novus Biologicals CYBRD1 Antibodies
    Abcam antibodies for CYBRD1
    Cloud-Clone Corp. Antibodies for CYBRD1
    ThermoFisher Antibodies for CYBRD1
    LSBio Antibodies in human, mouse, rat for CYBRD1

    CYBRD1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CYBRD1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CYBRD1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CYBRD1
    Cloud-Clone Corp. CLIAs for CYBRD1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    CYB: Cytochrome b genes

    3 InterPro protein domains:
     IPR028838 Cybrd1
     IPR004877 Cyt_b561_euk
     IPR006593 Cyt_b561/ferric_Rdtase_TM

    Graphical View of Domain Structure for InterPro Entry Q53TN4

    ProtoNet protein and cluster: Q53TN4

    1 Blocks protein domain: IPB006593 Cytochrome b561 / ferric reductase transmembrane

    UniProtKB/Swiss-Prot: CYBR1_HUMAN, Q53TN4
    Similarity: Contains 1 cytochrome b561 domain


    CYBRD1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CYBR1_HUMAN, Q53TN4
    Function: Ferric-chelate reductase that reduces Fe(3+) to Fe(2+). Present at the brush border of duodenal
    enterocytes where it probably reduces dietary Fe(3+) thereby facilitating its transport into the mucosal cells.
    Uses ascorbate as electron donor. May be involved in extracellular ascorbate recycling in erythrocyte membranes.
    May also act as a ferrireductase in airway epithelial cells
    Induction: By iron deficiency (at protein level)

         Enzyme Number (IUBMB): EC 1.-.-.-1

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000293ferric-chelate reductase activity IDA14499595
    GO:0016722oxidoreductase activity, oxidizing metal ions TAS--
    GO:0046872metal ion binding IEA--
         
    CYBRD1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CYBRD1:
     Decreased viability with pacli 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Cybrd1):
     homeostasis/metabolism  liver/biliary system 

    CYBRD1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Cybrd1tm1Nca for CYBRD1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CYBRD1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CYBRD1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CYBRD1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CYBRD1

    miRNA
    Products:
        
    miRTarBase miRNAs that target CYBRD1:
    hsa-mir-301a-3p (MIRT044230), hsa-mir-26b-5p (MIRT028908), hsa-mir-92a-3p (MIRT049718), hsa-mir-21-5p (MIRT030691), hsa-mir-124-3p (MIRT022211)

    Block miRNA regulation of human, mouse, rat CYBRD1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CYBRD1 (see all 75):
    hsa-miR-579 hsa-miR-26a-2* hsa-miR-520e hsa-miR-106a hsa-miR-3074-3p hsa-miR-374a hsa-miR-371-5p hsa-miR-629*
    SwitchGear 3'UTR luciferase reporter plasmidCYBRD1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CYBRD1
    Predesigned siRNA for gene silencing in human, mouse, rat CYBRD1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CYBRD1

    Clone
    Products:
         
    OriGene clones in human, mouse for CYBRD1 (see all 11)
    OriGene ORF clones in mouse, rat for CYBRD1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CYBRD1 (NM_001127383)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CYBRD1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CYBRD1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CYBRD1
    Browse ESI BIO Cell Lines and PureStem Progenitors for CYBRD1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYBRD1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    CYBR1_HUMAN, Q53TN4: Membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    cytosol1
    extracellular1
    golgi apparatus1
    nucleus1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--
    GO:0031526brush border membrane IEA--
    GO:0070062extracellular vesicular exosome IDA19056867

    CYBRD1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for CYBRD1 About    
    See pathways by source

    SuperPathContained pathways About
    1Insulin receptor recycling
    Iron uptake and transport0.70
    2Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    Transmembrane transport of small molecules0.47
    3Mineral absorption
    Mineral absorption

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for CYBRD1
        Iron uptake and transport


    1 Kegg Pathway  (Kegg details for CYBRD1):
        Mineral absorption


    CYBRD1 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CYBRD1
    Interactions:

        GeneGlobe Interaction Network for CYBRD1

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    3 Interacting proteins for CYBRD1 (Q53TN43 ENSP000003191414) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NAPBQ9H1153I2D: score=1 
    STX4Q128463I2D: score=1 
    SLC11A2ENSP000002620524STRING: ENSP00000262052
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006879cellular iron ion homeostasis TAS--
    GO:0010039response to iron ion IEA--
    GO:0055085transmembrane transport TAS--

    CYBRD1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CYBRD1 (CYBR1)

    2 HMDB Compounds for CYBRD1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Heme(protoporphyrinato)iron (see all 19)14875-96-8--
    IronArmco iron (see all 19)7439-89-6--

    3 Novoseek inferred chemical compound relationships for CYBRD1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    iron 62.3 38 17087784 (7), 16137899 (4), 12949720 (4), 18492824 (3) (see all 10)
    fe3+ 53.1 1 12196176 (1)
    ascorbic acid 51 5 20184953 (2), 18194661 (2)



    CYBRD1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for CYBRD1 gene (3 alternative transcripts): 
    NM_001127383.1  NM_001256909.1  NM_024843.3  

    Unigene Cluster for CYBRD1:

    Cytochrome b reductase 1
    Hs.221941  [show with all ESTs]
    Unigene Representative Sequence: NM_024843
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000409484 ENST00000468308 ENST00000321348(uc002ugy.4 uc002ugz.4)
    ENST00000375252 ENST00000474182 ENST00000494587 ENST00000445146
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CYBRD1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CYBRD1 (see all 75):
    hsa-miR-579 hsa-miR-26a-2* hsa-miR-520e hsa-miR-106a hsa-miR-3074-3p hsa-miR-374a hsa-miR-371-5p hsa-miR-629*
    SwitchGear 3'UTR luciferase reporter plasmidCYBRD1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CYBRD1
    Predesigned siRNA for gene silencing in human, mouse, rat CYBRD1
    Clone
    Products:
         
    OriGene clones in human, mouse for CYBRD1 (see all 11)
    OriGene ORF clones in mouse, rat for CYBRD1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CYBRD1 (NM_001127383)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CYBRD1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CYBRD1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CYBRD1
    OriGene qSTAR qPCR primer pairs in human, mouse for CYBRD1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CYBRD1
      QuantiTect SYBR Green Assays in human, mouse, rat CYBRD1
      QuantiFast Probe-based Assays in human, mouse, rat CYBRD1

    Additional mRNA sequence: 

    AK026654.1 AK027115.1 AK128495.1 AK225459.1 AK291731.1 AK301485.1 AK316588.1 AL136693.1 
    AL834483.1 BC016900.2 BC065290.1 

    9 DOTS entries:

    DT.445304  DT.99977849  DT.99950803  DT.100825490  DT.91880715  DT.91741788  DT.100037684  DT.100825493 
    DT.97833180 

    Selected AceView cDNA sequences (see all 329):

    AA299038 BM721523 AA947179 CA424915 CB117847 CR601938 BP341104 AA631537 
    CA437062 CA396900 BQ020071 AW963086 R09234 AI624177 AA284578 BC016900 
    CN481392 BQ029515 AA442294 C00322 CD677258 BP365431 BQ001790 BX095008 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for CYBRD1    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d
    SP1:                    -           -     -                                 
    SP2:                                -     -                                 
    SP3:                    -                                                   
    SP4:                    -     -     -     -                                 
    SP5:                                                                        


    ECgene alternative splicing isoforms for CYBRD1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    CYBRD1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAAGCTGTGC
    CYBRD1 Expression
    About this image


    CYBRD1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 15) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon
     
     Lung (Respiratory System)
             Alveolar type II cells
     
     Epidermis (Integumentary System)
             Detroit 551
     
     Fibroblasts
             Detroit 551
     
     Blood (Hematopoietic System)
             Erythroblasts Hematopoietic Bone Marrow
    CYBRD1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CYBRD1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.221941

    UniProtKB/Swiss-Prot: CYBR1_HUMAN, Q53TN4
    Tissue specificity: Present in erythrocyte membranes (at protein level). Also expressed in respiratory epithelium

        Custom PCR Arrays for CYBRD1
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CYBRD1
    OriGene qSTAR qPCR primer pairs in human, mouse for CYBRD1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CYBRD1
    QuantiTect SYBR Green Assays in human, mouse, rat CYBRD1
    QuantiFast Probe-based Assays in human, mouse, rat CYBRD1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYBRD1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for CYBRD1 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cybrd11 , 5 cytochrome b reductase 11, 5 79.49(n)1
    75.52(a)1
      2 (42.38 cM)5
    736491  NM_028593.21  NP_082869.21 
     711179235 
    chicken
    (Gallus gallus)
    Aves CYBRD11 cytochrome b reductase 1 72.44(n)
    68.9(a)
      424152  XM_421999.4  XP_421999.4 
    lizard
    (Anolis carolinensis)
    Reptilia CYBRD16
    cytochrome b reductase 1
    59(a)
    1 ↔ 1
    GL343353.1(1071811-1094531)
    African clawed frog
    (Xenopus laevis)
    Amphibia BM179782.12   -- 77.55(n)    BM179782.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cybrd11 cytochrome b reductase 1 61.2(n)
    61.48(a)
      552960  NM_001020500.1  NP_001018336.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG12751 CG1275 51.54(n)
    44.44(a)
      38286  NM_167941.3  NP_728726.1 
    worm
    (Caenorhabditis elegans)
    Secernentea F55H2.56
    F39G3.56
    (see all 3)
    Protein F39G3.5, isoform a
    (see all 3)
    26(a)
    24(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    III(9511475-9512954) WBGene00010131
    V(4722620-4724565) WBGene00018210


    ENSEMBL Gene Tree for CYBRD1 (if available)
    TreeFam Gene Tree for CYBRD1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for CYBRD1 gene
    CYB5612  CYB561A32  
    2 SIMAP similar genes for CYBRD1 using alignment to 2 protein entries:     CYBR1_HUMAN (see all proteins):
    CYB561A3    CYB561

    CYBRD1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Polymorphic Variants from UniProtKB/Swiss-Prot
    CYBR1_HUMAN, Q53TN4: Genetic variations in CYBRD1 may act as modifier of iron overload expression and account for the
    variance observed in serum ferritin levels in patients with hereditary hemochromatosis


    Selected SNPs for CYBRD1 (see all 860)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs714014291,2
    C--171780486(+) GTCTC-/AAAAAA 3 -- int11Minor allele frequency- A:0.50NA 2
    rs750493621,2
    C,F--172376769(+) CAAGAC/TGGCAA 1 -- us2k11Minor allele frequency- T:0.22WA 118
    rs38065621,2
    C,F,H--172376785(+) CAATAT/CAGCAA 1 -- us2k125Minor allele frequency- C:0.18EA NA NS WA CSA 3781
    rs1490784401,2
    --172376807(+) GAGATA/GAGCTA 1 -- us2k10--------
    rs1431936071,2
    --172376824(+) AGGGCG/TAGAAG 1 -- us2k10--------
    rs1884065481,2
    --172376921(+) GTCCAA/GTGGAG 3 -- us2k10--------
    rs38065631,2
    C,F,H--172376933(+) AGGGTG/AAGGAT 3 -- us2k125Minor allele frequency- A:0.18EA NS NA WA CSA 3466
    rs728843171,2
    C--172376961(+) AGGGAG/ACAAGC 3 -- us2k13Minor allele frequency- A:0.07NA EA 242
    rs38065641,2
    C,F,A--172376963(+) GGAGCA/GAGCTT 3 -- us2k113Minor allele frequency- G:0.14EA NA WA CSA 1688
    rs38065651,2
    C,F,A,H--172377000(+) CAAATT/CGGTTT 3 -- us2k116Minor allele frequency- C:0.15EA NS NA WA CSA 2034

    HapMap Linkage Disequilibrium report for CYBRD1 (172378757 - 172414643 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CYBRD1: --
    Human Gene Mutation Database (HGMD): CYBRD1
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing CYBRD1
    DNA2.0 Custom Variant and Variant Library Synthesis for CYBRD1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 605745    OMIM disorders: --

    9 diseases for CYBRD1:    
    About MalaCards
    duodenitis    siderosis    hemochromatosis    iron deficiency anemia
    deficiency anemia    porphyria cutanea tarda    porphyria    myocardial infarction
    malaria

    1 disease from the University of Copenhagen DISEASES database for CYBRD1:
    Hemochromatosis

    CYBRD1 for disorders           About GeneDecksing

    4 Novoseek inferred disease relationships for CYBRD1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hereditary hemochromatosis 80.7 1 16137899 (1)
    iron deficiency 68.5 9 17087784 (3), 12949720 (3), 16137899 (2)
    iron overload 60.1 3 15338274 (2), 14618243 (1)
    hemochromatosis 57.3 4 12949720 (3)

    Genetic Association Database (GAD): CYBRD1
    Human Genome Epidemiology (HuGE) Navigator: CYBRD1 (5 documents)

    Export disorders for CYBRD1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for CYBRD1 gene, integrated from 10 sources (see all 41):
    (articles sorted by number of sources associating them with CYBRD1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Analysis of genes implicated in iron regulation in individuals presenting with primary iron overload. (PubMed id 15338274)1, 2, 4, 9 Zaahl M.G.... Robson K.J.H. (Hum. Genet. 2004)
    2. A novel association between a SNP in CYBRD1 and serum ferritin levels in a cohort study of HFE hereditary haemochromatosis. (PubMed id 19673882)1, 2, 4 Constantine C.C....Gurrin L.C. (Br. J. Haematol. 2009)
    3. Duodenal cytochrome b and hephaestin expression in patients with iron deficiency and hemochromatosis. (PubMed id 12949720)1, 2, 9 Zoller H.... Weiss G. (Gastroenterology 2003)
    4. Examination of genetic polymorphisms in newborns for signatures of sex-specific prenatal selection. (PubMed id 20587610)1, 4 Ucisik-Akkaya E....Dorak M.T. (Mol. Hum. Reprod. 2010)
    5. Gene variants associated with ischemic stroke: the cardiovascular health study. (PubMed id 19023099)1, 4 Luke M.M....Psaty B.M. ( a journal of cerebral circulation 2009)
    6. Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study. (PubMed id 17975119)1, 4 Shiffman D....Psaty B.M. (Arterioscler. Thromb. Vasc. Biol. 2008)
    7. Human erythrocyte membranes contain a cytochrome b561 that may be involved in extracellular ascorbate recycling. (PubMed id 17068337)1, 2 Su D.... Asard H. (J. Biol. Chem. 2006)
    8. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (Genome Res. 2001)
    9. An iron-regulated ferric reductase associated with the absorption of dietary iron. (PubMed id 11230685)1, 3 McKie A.T....Simpson R.J. (Science 2001)
    10. Functional characterization of human duodenal cytochrome b (Cybrd1): Redox properties in relation to iron and ascorbate metabolism. (PubMed id 18194661)1, 9 Oakhill J.S....McKie A.T. (Biochim. Biophys. Acta 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 79901 HGNC: 20797 AceView: CYBRD1 Ensembl:ENSG00000071967 euGenes: HUgn79901
    ECgene: CYBRD1 Kegg: 79901 H-InvDB: CYBRD1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for CYBRD1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for CYBRD1 gene:
    Search GeneIP for patents involving CYBRD1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for CYBRD1   OriGene RNAi products in human, mouse, rat for CYBRD1  
     OriGene qPCR primer pairs and template standards for CYBRD1   OriGene Protein Over-expression Lysate for CYBRD1  
     OriGene MassSpec something-or-other for CYBRD1   OriGene clones in human, mouse for CYBRD1  
     OriGene qSTAR qPCR primer pairs in human, mouse for CYBRD1   OriGene Purified Protein for CYBRD1  
     OriGene ORF clones in mouse, rat for CYBRD1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CYBRD1   OriGene Custom Protein Services for CYBRD1  

     
     
     Block miRNA regulation of human, mouse, rat CYBRD1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing CYBRD1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CYBRD1 Predesigned siRNA for gene silencing in human, mouse, rat CYBRD1
     QuantiFast Probe-based Assays in human, mouse, rat CYBRD1 QuantiTect SYBR Green Assays in human, mouse, rat CYBRD1
     Custom PCR Arrays for CYBRD1 Search Chromatin IP Primers for CYBRD1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CYBRD1  GeneGlobe Interaction Network for CYBRD1
     Regulatory tfbs in CYBRD1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for CYBRD1 GenScript cDNA clones with any tag delivered in your preferred vector for CYBRD1
     GenScript Custom Assay Services for CYBRD1 GenScript Custom overexpressing Cell Line Services for CYBRD1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for CYBRD1 (CYBR1)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     CYBRD1 antibodies
     CYBRD1 proteins
     CYBRD1 lysates
     Antibodies for CYBRD1
     See all of Abcam's Antibodies, Kits and Proteins for CYBRD1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for CYBRD1
     Antibodies for CYBRD1
     ELISAs for CYBRD1
     CLIAs for CYBRD1



     Browse ESI BIO Cell Lines and PureStem Progenitors for CYBRD1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYBRD1
     SwitchGear 3'UTR luciferase reporter plasmids for CYBRD1
     SwitchGear Promoter luciferase reporter plasmids for CYBRD1
     ThermoFisher Antibodies for CYBRD1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CYBRD1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CYBRD1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CYBRD1
     LSBio Antibodies in human, mouse, rat for CYBRD1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CYBRD1 gene at Home site.
    Version: 3.12.142 28 July 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4