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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CYBRD1 Gene

protein-coding   GIFtS: 60
GCID: GC02P172378

Cytochrome B Reductase 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Cytochrome B Reductase 11 2     Cytochrome B561 Family1
Ferric-Chelate Reductase 31 2 3     Member A21
Duodenal Cytochrome B2 3     CYB561A22
DCYTB2 3     Cytochrome B561 Family, Member A22
FRRS32 3     EC 1.-.-.-3

External Ids:    HGNC: 207971   Entrez Gene: 799012   Ensembl: ENSG000000719677   OMIM: 6057455   UniProtKB: Q53TN43   

Export aliases for CYBRD1 gene to outside databases

Previous GC identifers: GC02P172342 GC02P172581 GC02P172204 GC02P172087 GC02P164264


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CYBRD1 Gene:
This gene is a member of the cytochrome b(561) family that encodes an iron-regulated protein. It highly expressed
in the duodenal brush border membrane. It has ferric reductase activity and is believed to play a physiological
role in dietary iron absorption. (provided by RefSeq, Jul 2008)

GeneCards Summary for CYBRD1 Gene: 
CYBRD1 (cytochrome b reductase 1) is a protein-coding gene. Diseases associated with CYBRD1 include duodenitis, and siderosis, and among its related super-pathways are Transferrin endocytosis and recycling and SLC-mediated transmembrane transport. GO annotations related to this gene include oxidoreductase activity, oxidizing metal ions and ferric-chelate reductase activity. An important paralog of this gene is CYB561.

UniProtKB/Swiss-Prot: CYBR1_HUMAN, Q53TN4
Function: Ferric-chelate reductase that reduces Fe(3+) to Fe(2+). Present at the brush border of duodenal
enterocytes where it probably reduces dietary Fe(3+) thereby facilitating its transport into the mucosal cells.
Uses ascorbate as electron donor. May be involved in extracellular ascorbate recycling in erythrocyte membranes.
May also act as a ferrireductase in airway epithelial cells




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.2  NT_005403.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CYBRD1 gene promoter:
         Pax-5   Tal-1   Brachyury   p300   HSF1 (long)   RelA   E47   CP2   HSF1short   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCYBRD1 promoter sequence
   Search SABiosciences Chromatin IP Primers for CYBRD1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CYBRD1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q31.1   Ensembl cytogenetic band:  2q31.1   HGNC cytogenetic band: 2q31

CYBRD1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CYBRD1 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P172378:  view genomic region     (about GC identifiers)

Start:
172,378,757 bp from pter      End:
172,414,643 bp from pter
Size:
35,887 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CYBR1_HUMAN, Q53TN4 (See protein sequence)
Recommended Name: Cytochrome b reductase 1  
Size: 286 amino acids; 31641 Da
Cofactor: Binds 2 heme groups non-covalently (By similarity)
Subcellular location: Membrane; Multi-pass membrane protein
Sequence caution: Sequence=CAG29366.1; Type=Erroneous gene model prediction; Sequence=CAG29367.1; Type=Erroneous
gene model prediction;
Secondary accessions: B2RE79 B4DWD7 Q6KC16 Q6KC17 Q6P147 Q6ZR51 Q9H0Q8 Q9H5G5
Alternative splicing: 3 isoforms:  Q53TN4-1   Q53TN4-2   Q53TN4-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CYBRD1: NX_Q53TN4

Explore proteomics data for CYBRD1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q53TN4

  • CYBRD1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CYBRD1 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001120855.1  NP_001243838.1  NP_079119.3  

    ENSEMBL proteins: 
     ENSP00000386739   ENSP00000319141   ENSP00000364401   ENSP00000402242  
    Reactome Protein details: Q53TN4
    Human Recombinant Protein Products for CYBRD1: 
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    Cloud-Clone Corp. Proteins for CYBRD1 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral to membrane IEA--
    GO:0031526brush border membrane IEA--

    CYBRD1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CYB: Cytochrome b genes

    2 InterPro protein domains:
     IPR004877 Cyt_b561_euk
     IPR006593 Cyt_b561/ferric_Rdtase_TM

    Graphical View of Domain Structure for InterPro Entry Q53TN4

    ProtoNet protein and cluster: Q53TN4

    1 Blocks protein domain: IPB006593 Cytochrome b561 / ferric reductase transmembrane

    UniProtKB/Swiss-Prot: CYBR1_HUMAN, Q53TN4
    Similarity: Contains 1 cytochrome b561 domain


    CYBRD1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CYBR1_HUMAN, Q53TN4
    Function: Ferric-chelate reductase that reduces Fe(3+) to Fe(2+). Present at the brush border of duodenal
    enterocytes where it probably reduces dietary Fe(3+) thereby facilitating its transport into the mucosal cells.
    Uses ascorbate as electron donor. May be involved in extracellular ascorbate recycling in erythrocyte membranes.
    May also act as a ferrireductase in airway epithelial cells
    Induction: By iron deficiency (at protein level)

         Enzyme Number (IUBMB): EC 1.-.-.-1

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000293ferric-chelate reductase activity IDA14499595
    GO:0016722oxidoreductase activity, oxidizing metal ions TAS--
    GO:0046872metal ion binding IEA--
         
    CYBRD1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CYBRD1:
     Decreased viability with pacli 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Cybrd1):
     homeostasis/metabolism  liver/biliary system 

    CYBRD1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Cybrd1tm1Nca for CYBRD1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CYBRD1 
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    SwitchGear 3'UTR luciferase reporter plasmidCYBRD1 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CYBRD1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Insulin receptor recycling
    Iron uptake and transport0.69
    2SLC-mediated transmembrane transport
    Transmembrane transport of small molecules0.50
    3Mineral absorption
    Mineral absorption

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2        Reactome Pathways for CYBRD1
        Transmembrane transport of small molecules
    Iron uptake and transport


    1         Kegg Pathway  (Kegg details for CYBRD1):
        Mineral absorption


    CYBRD1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CYBRD1

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    3 Interacting proteins for CYBRD1 (Q53TN43 ENSP000003191414) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NAPBQ9H1153I2D: score=1 
    STX4Q128463I2D: score=1 
    SLC11A2ENSP000002620524STRING: ENSP00000262052
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006879cellular iron ion homeostasis TAS--
    GO:0010039response to iron ion IEA--
    GO:0022900electron transport chain ----
    GO:0055085transmembrane transport TAS--

    CYBRD1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CYBRD1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for CYBRD1 (CYBR1)

    2 HMDB Compounds for CYBRD1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Heme(protoporphyrinato)iron (see all 19)14875-96-8--
    IronArmco iron (see all 19)7439-89-6--

    3 Novoseek inferred chemical compound relationships for CYBRD1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    iron 62.3 38 17087784 (7), 16137899 (4), 12949720 (4), 18492824 (3) (see all 10)
    fe3+ 53.1 1 12196176 (1)
    ascorbic acid 51 5 20184953 (2), 18194661 (2)

    Search CenterWatch for drugs/clinical trials and news about CYBRD1 / CYBR1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CYBRD1 gene (3 alternative transcripts): 
    NM_001127383.1  NM_001256909.1  NM_024843.3  

    Unigene Cluster for CYBRD1:

    Cytochrome b reductase 1
    Hs.221941  [show with all ESTs]
    Unigene Representative Sequence: NM_024843
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000409484 ENST00000468308 ENST00000321348(uc002ugy.4 uc002ugz.4)
    ENST00000375252 ENST00000474182 ENST00000494587 ENST00000445146
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    Additional mRNA sequence: 

    AK026654.1 AK027115.1 AK128495.1 AK225459.1 AK291731.1 AK301485.1 AK316588.1 AL136693.1 
    AL834483.1 BC016900.2 BC065290.1 

    9 DOTS entries:

    DT.445304  DT.99977849  DT.99950803  DT.100825490  DT.91880715  DT.91741788  DT.100037684  DT.100825493 
    DT.97833180 

    24/329 AceView cDNA sequences (see all 329):

    AI624177 AA284834 BC016900 C00322 BM723590 CA396900 CA424915 CB267760 
    AA631537 AV682689 W42866 AA442294 BM721523 AA947179 CR601938 AA693926 
    AA299038 CA437062 AA865198 BQ030018 BP341104 CD677258 AL597707 BQ029515 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for CYBRD1    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d
    SP1:                    -           -     -                                 
    SP2:                                -     -                                 
    SP3:                    -                                                   
    SP4:                    -     -     -     -                                 
    SP5:                                                                        


    ECgene alternative splicing isoforms for CYBRD1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CYBRD1 expression in normal human tissues (normalized intensities)      CYBRD1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAAGCTGTGC
    CYBRD1 Expression
    About this image


    CYBRD1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/7 selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Hypothalamus
             brain/midbrain   
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon
     
     Lung (Respiratory System)
             trachea   
     
     Intestine (Gastrointestinal Tract)
             duodenum   
     
     Epidermis (Integumentary System)
             Detroit 551

    See CYBRD1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CYBRD1

    SOURCE GeneReport for Unigene cluster: Hs.221941

    UniProtKB/Swiss-Prot: CYBR1_HUMAN, Q53TN4
    Tissue specificity: Present in erythrocyte membranes (at protein level). Also expressed in respiratory epithelium

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CYBRD1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CYBRD1 gene from 9/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cybrd11 , 5 cytochrome b reductase 11, 5 79.49(n)1
    75.52(a)1
      2 (42.38 cM)5
    736491  NM_028593.21  NP_082869.21 
     711179235 
    chicken
    (Gallus gallus)
    Aves CYBRD11 cytochrome b reductase 1 69.36(n)
    65.47(a)
      424152  XM_421999.3  XP_421999.3 
    lizard
    (Anolis carolinensis)
    Reptilia CYBRD16
    Uncharacterized protein
    56(a)
    1 ↔ 1
    GL343353.1(1071811-1094531)
    African clawed frog
    (Xenopus laevis)
    Amphibia BM179782.12   -- 77.55(n)    BM179782.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cybrd11 cytochrome b reductase 1 62.29(n)
    63.56(a)
      552960  NM_001020500.1  NP_001018336.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG12751 CG1275 51.54(n)
    44.44(a)
      38286  NM_139446.3  NP_647703.1 
    worm
    (Caenorhabditis elegans)
    Secernentea CELE_F55H2.51 Protein F55H2.5 43.89(n)
    32.13(a)
      186343  NM_066694.1  NP_499095.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ACYB-21 cytochrome b561/ferric reductase transmembrane family more 47.93(n)
    36.82(a)
      828662  NM_118689.3  NP_567723.1 
    rice
    (Oryza sativa)
    Liliopsida Os04g05335001 hypothetical protein 46.09(n)
    36.73(a)
      4336503  NM_001059945.1  NP_001053410.1 


    ENSEMBL Gene Tree for CYBRD1 (if available)
    TreeFam Gene Tree for CYBRD1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CYBRD1 gene
    CYB5612  CYB561A32  
    2 SIMAP similar genes for CYBRD1 using alignment to 2 protein entries:     CYBR1_HUMAN (see all proteins):
    CYB561A3    CYB561

    CYBRD1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: CYBR1_HUMAN, Q53TN4
    Polymorphism: Genetic variations in CYBRD1 may act as modifier of iron overload expression and account for the
    variance observed in serum ferritin levels in patients with hereditary hemochromatosis


    10/860 SNPs in CYBRD1 are shown (see all 860)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs714014291,2
    C--171780486(+) GTCTC-/AAAAAA 3 -- int11Minor allele frequency- A:0.50NA 2
    rs750493621,2
    C,F--172376769(+) CAAGAC/TGGCAA 1 -- us2k11Minor allele frequency- T:0.22WA 118
    rs38065621,2
    C,F,H--172376785(+) CAATAT/CAGCAA 1 -- us2k125Minor allele frequency- C:0.18EA NA NS WA CSA 3781
    rs1490784401,2
    --172376807(+) GAGATA/GAGCTA 1 -- us2k10--------
    rs1431936071,2
    --172376824(+) AGGGCG/TAGAAG 1 -- us2k10--------
    rs1884065481,2
    --172376921(+) GTCCAA/GTGGAG 3 -- us2k10--------
    rs38065631,2
    C,F,H--172376933(+) AGGGTG/AAGGAT 3 -- us2k125Minor allele frequency- A:0.18EA NS NA WA CSA 3466
    rs728843171,2
    C--172376961(+) AGGGAG/ACAAGC 3 -- us2k13Minor allele frequency- A:0.07NA EA 242
    rs38065641,2
    C,F,A--172376963(+) GGAGCA/GAGCTT 3 -- us2k113Minor allele frequency- G:0.14EA NA WA CSA 1688
    rs38065651,2
    C,F,A,H--172377000(+) CAAATT/CGGTTT 3 -- us2k116Minor allele frequency- C:0.15EA NS NA WA CSA 2034

    HapMap Linkage Disequilibrium report for CYBRD1 (172378757 - 172414643 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CYBRD1: --

    Human Gene Mutation Database (HGMD): CYBRD1
    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing CYBRD1
    DNA2.0 Custom Variant and Variant Library Synthesis for CYBRD1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605745    OMIM disorders: --

    6 diseases for CYBRD1:    About MalaCards
    duodenitis    siderosis    hemochromatosis    iron deficiency anemia
    anemia    myocardial infarction

    1 disease from the University of Copenhagen DISEASES database for CYBRD1:
    Hemochromatosis

    CYBRD1 for disorders           About GeneDecksing

    4 Novoseek inferred disease relationships for CYBRD1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hereditary hemochromatosis 80.7 1 16137899 (1)
    iron deficiency 68.5 9 17087784 (3), 12949720 (3), 16137899 (2)
    iron overload 60.1 3 15338274 (2), 14618243 (1)
    hemochromatosis 57.3 4 12949720 (3)

    Genetic Association Database (GAD): CYBRD1
    Human Genome Epidemiology (HuGE) Navigator: CYBRD1 (5 documents)

    Export disorders for CYBRD1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CYBRD1 gene, integrated from 9 sources (see all 39):
    (articles sorted by number of sources associating them with CYBRD1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Analysis of genes implicated in iron regulation in individuals presenting with primary iron overload. (PubMed id 15338274)1, 2, 4, 9 Zaahl M.G.... Robson K.J.H. (2004)
    2. A novel association between a SNP in CYBRD1 and serum ferritin levels in a cohort study of HFE hereditary haemochromatosis. (PubMed id 19673882)1, 2, 4 Constantine C.C....Gurrin L.C. (2009)
    3. Duodenal cytochrome b and hephaestin expression in patients with iron deficiency and hemochromatosis. (PubMed id 12949720)1, 2, 9 Zoller H....Weiss G. (2003)
    4. Examination of genetic polymorphisms in newborns for signatures of sex-specific prenatal selection. (PubMed id 20587610)1, 4 Ucisik-Akkaya E....Tevfik Dorak M. (2010)
    5. Gene variants associated with ischemic stroke: the cardiovascular health study. (PubMed id 19023099)1, 4 Luke M.M....Psaty B.M. (2009)
    6. Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study. (PubMed id 17975119)1, 4 Shiffman D....Psaty B.M. (2008)
    7. Human erythrocyte membranes contain a cytochrome b561 that may be involved in extracellular ascorbate recycling. (PubMed id 17068337)1, 2 Su D.... Asard H. (2006)
    8. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
    9. An iron-regulated ferric reductase associated with the absorption of dietary iron. (PubMed id 11230685)1, 3 McKie A.T....Simpson R.J. (2001)
    10. Functional characterization of human duodenal cytochrome b (Cybrd1): Redox properties in relation to iron and ascorbate metabolism. (PubMed id 18194661)1, 9 Oakhill J.S....McKie A.T. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 79901 HGNC: 20797 AceView: CYBRD1 Ensembl:ENSG00000071967 euGenes: HUgn79901
    ECgene: CYBRD1 Kegg: 79901 H-InvDB: CYBRD1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CYBRD1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CYBRD1 gene:
    Search GeneIP for patents involving CYBRD1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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