CYBA Gene
protein-coding GIFtS: 63
GCID: GC16M088709
|
|
cytochrome b-245, alpha polypeptide
| |
Aliases
for CYBA gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Cytochrome B-245, Alpha Polypeptide1 2 | | P22phox1 | | P22-PHOX1 | | Cytochrome B Light Chain2 | | Cytochrome B(558) Alpha Chain2 3 | | Cytochrome B(558) Alpha-Subunit2 | | Cytochrome B558 Subunit Alpha2 3 | | Cytochrome B, Alpha Polypeptide2 | | Neutrophil Cytochrome B 22 KDa Polypeptide2 3 | | Cytochrome B-245 Light Chain2 | | Superoxide-Generating NADPH Oxidase Light Chain Subunit2 3 | | Flavocytochrome B-558 Alpha Polypeptide2 | | P22 Phagocyte B-Cytochrome2 3 | | P22-Phox1 |
Export aliases for CYBA gene to outside databasesPrevious GC identifers: GC16M080145 GC16M089678 GC16M088413 GC16M088453 GC16M087237 GC16M074403 |
Summaries
for CYBA gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CYBA:
Cytochrome b is comprised of a light chain (alpha) and a heavy chain (beta). This gene encodes the light, alpha subunitwhich has been proposed as a primary component of the microbicidal oxidase system of phagocytes. Mutations in thisgene are associated with autosomal recessive chronic granulomatous disease (CGD), that is characterized by the failureof activated phagocytes to generate superoxide, which is important for the microbicidal activity of these cells.(provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: CY24A_HUMAN, P13498Function: Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates withNOX3 to form a functional NADPH oxidase constitutively generating superoxide
Gene Wiki entry for CYBA (Cytochrome b-245, alpha polypeptide)
|
Genomic Views
for CYBA gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000016.9 NC_018927.1 NT_010542.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CYBA gene promoter:
Sp1 AP-1 p53 PPAR-gamma2
Other transcription factors
Search SABiosciences Chromatin IP Primers for CYBA
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CYBA |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16q24 Ensembl cytogenetic band: 16q24.3 HGNC cytogenetic band: 16q24CYBA Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16M088709: view genomic region
(about GC identifiers)
Start:
|
88,709,691 bp from pter |
End:
|
88,717,560 bp from pter |
Size:
|
7,870 bases |
Orientation:
|
minus strand |
|
Proteins
for CYBA gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CY24A_HUMAN, P13498 (See
protein sequence)Recommended Name: Cytochrome b-245 light chain Size: 195 amino acids; 21013 Da
Subunit: Composed of a heavy chain (beta) and a light chain (alpha). Interacts with SH3PXD2A (By similarity). Interactswith DUOX1, DUOX2 and TPO. Interacts with NOX3 and NOX4. Interacts with calprotectin (S100A8/9)
Subcellular location: Cell membrane
1 PDB 3D structure from  and Proteopedia  for CYBA:1WLP (3D)
Secondary accessions: Q14090 Q9BR72Explore the universe of human proteins at neXtProt for CYBA: NX_P13498
Post-translational modifications:
The heme prosthetic group could be coordinated with residues of the light chain, the heavy chain, or both, and it ispossible that more than one heme is present per cytochrome b-2451
Phosphorylation at Thr-147 enhances NADPH oxidase activity by promoting p47phox binding (By similarity)1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P13498
CYBA Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_000092.2
ENSEMBL proteins: ENSP00000261623 ENSP00000455537 ENSP00000457060 ENSP00000454951 ENSP00000456079 ENSP00000455506 Reactome Protein details: P13498
Human Recombinant Protein Products for CYBA:
Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10): About this table
CYBA for ontologies About GeneDecksing
CYBA Antibody Products:
Assay Products for CYBA: |
Protein
Domains /
Families
for CYBA gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CYBA for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry P13498ProtoNet protein and cluster: P13498 1 Blocks protein family: IPB007732 Cytochrome b558 alpha-subunit
UniProtKB/Swiss-Prot: CY24A_HUMAN, P13498Similarity: Belongs to the p22phox family |
Function
for CYBA gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: CY24A_HUMAN, P13498Function: Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates withNOX3 to form a functional NADPH oxidase constitutively generating superoxide Genatlas biochemistry entry for CYBA:cytochrome b-558,alpha polypeptide,(22kDa,membrane bound component of the NADPH oxidase system,cypb245),p22-phox,mainlyexpressed in neutrophiles,oxygen dependent mechanism of phagocytosis
Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table
CYBA for ontologies About GeneDecksing
Phenotypes:
3 GenomeRNAi human phenotypes for CYBA:
4 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Cyba):
CYBA for phenotypes About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CYBA (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CYBA
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: CYBA (NM_000101) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CYBA | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CYBA |
|
Pathways & Interactions
for CYBA gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/17 super-pathways (see all 17) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | G-protein signaling_RAC1 in cellular process | | | 2 | Immune response _CCR3 signaling in eosinophils | | | 3 | Immune System | | | 4 | Insulin receptor recycling | | | 5 | G-protein signaling Regulation of RAC1 activity | |
Pathway sources
See GeneCards unified pathways
Show all pathways
3 EMD Millipore Pathways for CYBA
1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for CYBA
4  GeneGo (Thomson Reuters) Pathways for CYBA
2  BioSystems Pathways for CYBA
5/8 
Reactome Pathways for CYBA (see all 8)
1  PharmGKB Pathway for CYBA
4 
Kegg Pathways (Kegg details for CYBA):
CYBA for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CYBA
STRING Interaction
Network Preview (showing 5 interactants - click image to see 24)
5/27 Interacting proteins for CYBA (P134981, 2, 3 ENSP000002616234) via UniProtKB, MINT, STRING, and/or I2D (see all 27)About this table
Gene Ontology (GO): 5/29 biological process terms (GO ID links to tree view) (see all 29): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0001938 | positive regulation of endothelial cell proliferation |
IEA | -- | | GO:0002474 | antigen processing and presentation of peptide antigen via MHC class I |
TAS | -- | | GO:0002479 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent |
TAS | -- | | GO:0003106 | negative regulation of glomerular filtration by angiotensin |
IEA | -- | | GO:0006801 | superoxide metabolic process |
IMP | 2243141 |
CYBA for ontologies About GeneDecksing
|
Drugs & Compounds
for CYBA gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
CYBA for compounds About GeneDecksing
 Browse Tocris compounds for CYBA
2 HMDB Compounds for CYBA About this table
| Compound | Synonyms |
CAS
# | PubMed Ids |
|---|
| Heme | (protoporphyrinato)iron (see all 19) | 14875-96-8 | -- | | NADPH | 2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide (see all 23) | 53-57-6 | -- |
10/27 Novoseek chemical compound relationships for CYBA gene (see all 27) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| nadph |
93 |
204 |
10893420 (5), 16759310 (5), 10593961 (4), 15210651 (4) (see all 99) |
| superoxide |
81.1 |
40 |
16460309 (3), 10788501 (2), 9856978 (2), 17880563 (2) (see all 29) |
| diphenyleneiodonium |
77.5 |
5 |
15683718 (1), 18958420 (1), 11980681 (1) |
| apocynin |
72.3 |
1 |
18092937 (1) |
| oxygen |
65 |
16 |
15994299 (4), 10996353 (1), 16754784 (1), 18660448 (1) (see all 13) |
| nadh |
63.4 |
16 |
10583446 (1), 10720412 (1), 11133215 (1), 9445163 (1) (see all 14) |
| hocl |
41.5 |
1 |
12440767 (1) |
| n-formylmethionyl-leucylphenylalanine |
41.5 |
1 |
10893420 (1) |
| nitric oxide |
38.1 |
13 |
12514663 (1), 16738684 (1), 14561241 (1), 17081080 (1) (see all 8) |
| h2o2 |
37.7 |
6 |
15683718 (2), 8917565 (1), 12440767 (1), 18717627 (1) |
1 PharmGKB related drug/compound annotation for CYBA gene About this tableSearch CenterWatch for drugs/clinical trials and news about CYBA / CY24A
|
Transcripts
for CYBA gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CYBA gene: NM_000101.3 Unigene Cluster for CYBA: Cytochrome b-245, alpha polypeptide Hs.513803 [show with all ESTs]Unigene Representative Sequence: BQ71109410 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000261623(uc002flb.3) ENST00000565588 ENST00000566534(uc010chx.1)
ENST00000566229 ENST00000567174 ENST00000569359(uc002fld.1) ENST00000563526
ENST00000568278 ENST00000562209 ENST00000561972
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CYBA (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CYBA
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CYBA (NM_000101) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CYBA | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CYBA |
Additional cDNA sequence: AK300049.1 BC006465.1 BT006861.1 M21186.1 18 DOTS entries: DT.449843 DT.112624 DT.92060078 DT.100817057 DT.95363376 DT.317715 DT.40297132 DT.95166994 DT.75195756 DT.120656538 DT.40114988 DT.100817058 DT.120656519 DT.86835803 DT.92432291 DT.99965841 DT.120656543 DT.121394457 24/375 AceView cDNA sequences (see all 375): BI524270 AW152064 AA766274 AI673477 AI867529 BI521876 AI222391 AW268707 AI076057 BE676504 AI686369 CA489753 AA644008 AW276645 AI810889 BE675554 AI202296 AW662521 AW196420 BF063215 AI538549 AA284138 AI637488 BM148016
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for CYBA (see all 6) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 |
|---|
|
| SP1: | | | | | | | | | | | - | | - | | | | | | - | | - | | | | - | | - | | | | |
| SP2: | | | | | | | | | | | - | | - | | | | | | - | | - | | | | - | | | | | | |
| SP3: | | | | | | | | | | | - | | - | | | | | | - | | - | | | | | | | | | | |
| SP4: | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for CYBA
|
Expression
for CYBA gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CYBA expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACCGCCGTGG
About this image
See CYBA Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CYBA
SOURCE GeneReport for Unigene cluster: Hs.513803
SABiosciences Custom PCR Arrays for CYBA
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CYBA
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat CYBA | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CYBA | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CYBA |
Orthologs
for CYBA gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for CYBA gene from 4/15 species (see all 15) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Cyba1 , 5 |
cytochrome b-245, alpha polypeptide1, 5 |
81.94(n)1
88.02(a)1 |
|
8 (71.04 cM)5
130571 NM_007806.31 NP_031832.21
1224247725 |
lizard
(Anolis carolinensis) |
Reptilia |
CYBA6 |
-- |
75(a) |
1 ↔ 1 |
GL343670.1(98511-111451) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.59672 |
Xenopus laevis transcribed sequence with weak similarity more |
73.19(n) |
|
CF270763.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
zgc660772 |
hypothetical protein MGC66077 |
70.31(n) |
|
393551 BC056702.1 |
ENSEMBL Gene Tree for CYBA (if available)
TreeFam Gene Tree for CYBA (if available) |
Paralogs
for CYBA gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for CYBA gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 16 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CYBA (88709691 - 88717560 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for CYBA
2 CNVs: 4973 30011
Human Gene Mutation Database (HGMD): CYBA
Locus Specific Mutation Databases (LSDB): CYBA
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CYBA |
|
Disorders
/ Diseases
for CYBA gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CYBA for disorders About GeneDecksing
OMIM gene information: 608508
OMIM disorders: 233690
UniProtKB/Swiss-Prot: CY24A_HUMAN, P13498
Defects in CYBA are a cause of chronic granulomatous disease autosomal recessive cytochrome-b-negative (ARCGD)[MIM:233690]. Chronic granulomatous disease is a genetically heterogeneous disorder characterized by the inability ofneutrophils and phagocytes to kill microbes that they have ingested. Patients suffer from life-threateningbacterial/fungal infections
20/76  diseases for CYBA (see all 76): About MalaCardschronic granulomatous disease chronic granulomatous disease, autosomal, due to deficiency of cyba chronic granulomatous disease, autosomal recessive, cytochrome b-negative diffuse large b-cell lymphoma
leber hereditary optic neuropathy arterial occlusive disease thoracic aortic aneurysm peripheral arterial occlusive disease
b-cell lymphomas non-hodgkin lymphoma aortic aneurysm type 1 diabetes mellitus
coronary heart disease chronic obstructive pulmonary disease sleep apnea diabetes mellitus
insulin resistance tetralogy of fallot ectodermal dysplasia essential hypertension
3 diseases from the University of Copenhagen DISEASES database for CYBA:Chronic granulomatous disease Hypertension Atherosclerosis 10/17 Novoseek disease relationships for CYBA gene (see all 17) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| granulomatous disease chronic |
87.8 |
17 |
10910929 (2), 19292887 (2), 10452961 (1), 17101097 (1) (see all 15) |
| atherosclerosis |
49.7 |
11 |
12547880 (2), 11914250 (1), 18801380 (1), 10510050 (1) (see all 8) |
| coronary artery disease |
47.7 |
10 |
20100625 (2), 17627182 (1), 10996353 (1), 10700443 (1) (see all 8) |
| cardiovascular diseases |
40.1 |
2 |
17880563 (1), 15255799 (1) |
| coronary heart disease |
30.5 |
7 |
12905852 (2), 15193812 (1), 18324526 (1), 15461271 (1) (see all 6) |
| hypercholesterolemia |
20.3 |
4 |
17627182 (1), 12683949 (1), 15135268 (1) |
| genetic disorder |
18.4 |
2 |
17101097 (1), 12440767 (1) |
| necrosis |
12.2 |
1 |
11359957 (1) |
| diabetes mellitus |
7.97 |
2 |
15135268 (1) |
| hypertension arterial |
7.69 |
1 |
15255799 (1) |
Genatlas disease: CYBA chronic granulomatous disease,autosomal (cypb558 deficiency)
Genetic Association Database (GAD): CYBA
Human Genome Epidemiology (HuGE) Navigator: CYBA (123 documents)
Export disorders for CYBA gene to outside databases
|
Publications
for CYBA gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CYBA gene, integrated from 9 sources (see all 419):
(articles sorted by number of sources associating them with CYBA) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Human neutrophil cytochrome b light chain (p22-phox). Gene structure, chromosomal location, and mutations in cytochrome-negative autosomal recessive chronic granulomatous disease. (PubMed id 2243141)1, 2, 3 Dinauer M.C.... Orkin S.H. (1990)
- Genetic studies of three Japanese patients with p22-phox-deficient chronic granulomatous disease: detection of a possible common mutant CYBA allele in Japan and a genotype-phenotype correlation in these patients. (PubMed id 10759707)1, 2, 9 Yamada M.... Sakiyama Y. (2000)
- Three common polymorphisms in the CYBA gene form a haplotype associated with decreased ROS generation. (PubMed id 19388116)1, 2, 9 Bedard K.... Krause K.-H. (2009)
- Functional effect of the p22phox -930A/G polymorphism on p22phox expression and NADPH oxidase activity in hypertension. (PubMed id 15210651)1, 4, 9 San Jose G....Zalba G. (2004)
- Angiotensin-converting enzyme and p22(phox) polymorphisms and the risk of coronary heart disease in a low-risk Spanish population. (PubMed id 15193812)1, 4, 9 Mata-Balaguer T....Ruiz-Rejon F. (2004)
- Functional effects of NAD(P)H oxidase p22(phox) C242T mutation in human leukocytes and association with thrombotic cerebral infarction. (PubMed id 15186954)1, 4, 9 Shimo-Nakanishi Y....Urabe T. (2004)
- Endothelial venodilator response in carriers of genetic polymorphisms involved in NO synthesis and degradation. (PubMed id 15255799)1, 4, 9 Fricker R....Haefeli W.E. (2004)
- Nicotinamide adenine dinucleotide phosphate oxidase (NADPH oxidase) P22 Phox C242T gene polymorphism in type 1 diabetes. (PubMed id 14679084)1, 4, 9 Matsunaga S....Saruta T. (2003)
- 156Pro-->Gln substitution in the light chain of cytochrome b558 of the human NADPH oxidase (p22-phox) leads to defective translocation of the cytosolic proteins p47-phox and p67-phox. (PubMed id 7964505)1, 2, 9 Leusen J.H.... Verhoeven A.J. (1994)
- Cytochrome b558-negative, autosomal recessive chronic granulomatous disease: two new mutations in the cytochrome b558 light chain of the NADPH oxidase (p22-phox). (PubMed id 1415254)1, 2, 9 de Boer M.... Roos D. (1992)
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External Searches for CYBA gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing CYBA gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing CYBA gene
(According to HUGE)
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Specialized Databases showing CYBA gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CYBA | Pharmacogenomics, SNPs, Pathways | | CYBAbase | http://bioinf.uta.fi/CYBAbase/ | | GeneReviews | http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/CYBA | | SHMPD | http://shmpd.bii.a-star.edu.sg/gene.php?genestart=C&genename=CYBB+%40+GP91-PHOX |
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About This Section
| Patent Information for CYBA gene:
Search GeneIP for patents involving CYBA
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for CYBA gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
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| | |  | Browse OriGene Antibodies | | Browse OriGene shRNA RFPs | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CYBA | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CYBA | | | OriGene Protein Over-expression Lysate for CYBA | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CYBA | | OriGene 3'-UTR Clone for CYBA | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CYBA | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CYBA | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CYBA | | OriGene Custom Protein Services for CYBA | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CYBA | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CYBA | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CYBA | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CYBA | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CYBA | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CYBA |
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| | | | Search Tocris compounds for CYBA |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CYBA |
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