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Aliases for CYBA Gene

Aliases for CYBA Gene

  • Cytochrome B-245, Alpha Polypeptide 2 3
  • Superoxide-Generating NADPH Oxidase Light Chain Subunit 3 4
  • Neutrophil Cytochrome B 22 KDa Polypeptide 3 4
  • Flavocytochrome B-558 Alpha Polypeptide 2 3
  • Cytochrome B(558) Alpha Chain 3 4
  • Cytochrome B558 Subunit Alpha 3 4
  • P22 Phagocyte B-Cytochrome 3 4
  • P22-PHOX 3 4
  • P22phox 3 4
  • Cytochrome B(558) Alpha-Subunit 3
  • Cytochrome B, Alpha Polypeptide 3
  • Cytochrome B-245 Light Chain 3
  • Cytochrome B Light Chain 3

External Ids for CYBA Gene

Previous GeneCards Identifiers for CYBA Gene

  • GC16M080145
  • GC16M089678
  • GC16M088413
  • GC16M088453
  • GC16M087237
  • GC16M088709
  • GC16M074403

Summaries for CYBA Gene

Entrez Gene Summary for CYBA Gene

  • Cytochrome b is comprised of a light chain (alpha) and a heavy chain (beta). This gene encodes the light, alpha subunit which has been proposed as a primary component of the microbicidal oxidase system of phagocytes. Mutations in this gene are associated with autosomal recessive chronic granulomatous disease (CGD), that is characterized by the failure of activated phagocytes to generate superoxide, which is important for the microbicidal activity of these cells. [provided by RefSeq, Jul 2008]

GeneCards Summary for CYBA Gene

CYBA (Cytochrome B-245, Alpha Polypeptide) is a Protein Coding gene. Diseases associated with CYBA include chronic granulomatous disease, autosomal, due to deficiency of cyba and chronic granulomatous disease. Among its related pathways are Disease and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include protein heterodimerization activity and heme binding.

UniProtKB/Swiss-Prot for CYBA Gene

  • Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide.

Gene Wiki entry for CYBA Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CYBA Gene

Genomics for CYBA Gene

Regulatory Elements for CYBA Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CYBA Gene

88,643,283 bp from pter
88,651,152 bp from pter
7,870 bases
Minus strand

Genomic View for CYBA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CYBA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CYBA Gene

Proteins for CYBA Gene

  • Protein details for CYBA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cytochrome b-245 light chain
    Protein Accession:
    Secondary Accessions:
    • Q14090
    • Q9BR72

    Protein attributes for CYBA Gene

    195 amino acids
    Molecular mass:
    21013 Da
    Quaternary structure:
    • Composed of a heavy chain (beta) and a light chain (alpha). Component of an NADPH oxidase complex composed of a heterodimer formed by the membrane proteins CYBA and CYBB and the cytosolic subunits NCF1, NCF2 and NCF4. Interacts with NCF1 (via SH3 domain). Interacts with SH3PXD2A (By similarity). Interacts with DUOX1, DUOX2 and TPO. Interacts with NOX3 and NOX4. Interacts with calprotectin (S100A8/9).

    Three dimensional structures from OCA and Proteopedia for CYBA Gene

neXtProt entry for CYBA Gene

Proteomics data for CYBA Gene at MOPED

Post-translational modifications for CYBA Gene

  • Phosphorylation at Thr-147 enhances NADPH oxidase activity by promoting p47phox binding.
  • The heme prosthetic group could be coordinated with residues of the light chain, the heavy chain, or both, and it is possible that more than one heme is present per cytochrome b-245
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CYBA Gene

No data available for DME Specific Peptides for CYBA Gene

Domains for CYBA Gene

Protein Domains for CYBA Gene


Suggested Antigen Peptide Sequences for CYBA Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the p22phox family.
  • Belongs to the p22phox family.
genes like me logo Genes that share domains with CYBA: view

No data available for Gene Families for CYBA Gene

Function for CYBA Gene

Molecular function for CYBA Gene

GENATLAS Biochemistry:
cytochrome b-558,alpha polypeptide,(22kDa,membrane bound component of the NADPH oxidase system,cypb245),p22-phox,mainly expressed in neutrophiles,oxygen dependent mechanism of phagocytosis
UniProtKB/Swiss-Prot Function:
Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide.

Gene Ontology (GO) - Molecular Function for CYBA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11733522
GO:0009055 electron carrier activity TAS 2243141
GO:0016175 contributes_to superoxide-generating NADPH oxidase activity IMP 1763037
GO:0017124 SH3 domain binding IPI 7938008
GO:0020037 heme binding IEA --
genes like me logo Genes that share ontologies with CYBA: view
genes like me logo Genes that share phenotypes with CYBA: view

Animal Model Products

miRNA for CYBA Gene

miRTarBase miRNAs that target CYBA

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CYBA

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for CYBA Gene

Localization for CYBA Gene

Subcellular locations from UniProtKB/Swiss-Prot for CYBA Gene

Cell membrane.

Subcellular locations from

Jensen Localization Image for CYBA Gene COMPARTMENTS Subcellular localization image for CYBA gene
Compartment Confidence
plasma membrane 5
cytosol 2
extracellular 2
golgi apparatus 2
mitochondrion 2
endoplasmic reticulum 1
lysosome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for CYBA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm --
GO:0005739 mitochondrion IEA --
GO:0005768 endosome IEA --
GO:0005794 Golgi apparatus IEA --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with CYBA: view

Pathways for CYBA Gene

genes like me logo Genes that share pathways with CYBA: view

Gene Ontology (GO) - Biological Process for CYBA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001938 positive regulation of endothelial cell proliferation IEA --
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I TAS --
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS --
GO:0003106 negative regulation of glomerular filtration by angiotensin IEA --
GO:0006801 superoxide metabolic process IMP 1763037
genes like me logo Genes that share ontologies with CYBA: view

Drugs for CYBA Gene

(1) Drugbank Compounds for CYBA Gene

Compound Status Synonyms Cas Number PubChem ID Type Actions PubMed IDs
  • d-Methorphan
125-71-3 Target inhibitor approved

(2) HMDB Compounds for CYBA Gene

Compound Synonyms Cas Number PubMed IDs
  • (protoporphyrinato)iron
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide

(27) Novoseek inferred chemical compound relationships for CYBA Gene

Compound -log(P) Hits PubMed IDs
nadph 93 140
superoxide 81.1 36
diphenyleneiodonium 77.5 3
apocynin 72.3 1
oxygen 65 16

(2) PharmGKB related drug/compound annotations for CYBA Gene

Drug/compound Annotation
doxorubicin Clinical Annotation
simvastatin Clinical Annotation
genes like me logo Genes that share compounds with CYBA: view

Transcripts for CYBA Gene

Unigene Clusters for CYBA Gene

Cytochrome b-245, alpha polypeptide:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CYBA

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CYBA Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8
SP1: - - - - - -
SP2: - - - - -
SP3: - - - -
SP4: - -
SP5: - -

Relevant External Links for CYBA Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CYBA Gene

mRNA expression in normal human tissues for CYBA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CYBA Gene

This gene is overexpressed in Whole Blood (19.7) and Spleen (5.6).

Protein differential expression in normal tissues for CYBA Gene

This gene is overexpressed in Nasal epithelium (24.0), Neutrophil (16.5), and Monocytes (10.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CYBA Gene

SOURCE GeneReport for Unigene cluster for CYBA Gene Hs.513803

genes like me logo Genes that share expressions with CYBA: view

Expression partners for CYBA Gene

* - Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for CYBA Gene

Orthologs for CYBA Gene

This gene was present in the common ancestor of chordates.

Orthologs for CYBA Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CYBA 35
  • 85.51 (n)
  • 89.01 (a)
  • 88 (a)
(Canis familiaris)
Mammalia CYBA 35
  • 83.42 (n)
  • 85.13 (a)
  • 85 (a)
(Mus musculus)
Mammalia Cyba 35
  • 82.81 (n)
  • 90.53 (a)
Cyba 16
Cyba 36
  • 88 (a)
(Pan troglodytes)
Mammalia CYBA 35
  • 98.8 (n)
  • 98.97 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Cyba 35
  • 84.2 (n)
  • 90.62 (a)
(Monodelphis domestica)
Mammalia CYBA 36
  • 74 (a)
(Ornithorhynchus anatinus)
Mammalia CYBA 36
  • 75 (a)
(Gallus gallus)
Aves CYBA 36
  • 77 (a)
(Anolis carolinensis)
Reptilia CYBA 36
  • 75 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cyba 35
  • 64.88 (n)
  • 72.19 (a)
Str.15394 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.5967 35
(Danio rerio)
Actinopterygii cyba 35
  • 58.67 (n)
  • 62.86 (a)
zgc66077 35
cyba 36
  • 58 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8225 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 37 (a)
Species with no ortholog for CYBA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CYBA Gene

Gene Tree for CYBA (if available)
Gene Tree for CYBA (if available)

Paralogs for CYBA Gene

No data available for Paralogs for CYBA Gene

Variants for CYBA Gene

Sequence variations from dbSNP and Humsavar for CYBA Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs4673 Benign, - 88,646,828(-) AGAAG(C/T)ACATG missense, reference
rs12123 -- 88,643,560(-) GTGCG(C/T)GGYGA synonymous-codon, reference
rs1049254 - 88,643,420(-) TGCGG(C/T)GGCGG missense, reference
rs1049255 -- 88,643,329(-) CTCCC(A/G)CCAGG utr-variant-3-prime
rs1804006 -- 88,648,088(-) TGGCC(A/G)CAGCT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for CYBA Gene

Variant ID Type Subtype PubMed ID
nsv907226 CNV Loss 21882294
nsv907255 CNV Loss 21882294
nsv907264 CNV Loss 21882294
nsv833325 CNV Loss 17160897
nsv907268 CNV Loss 21882294
dgv2977n71 CNV Loss 21882294
dgv2978n71 CNV Loss 21882294
dgv2979n71 CNV Loss 21882294
nsv907278 CNV Loss 21882294
nsv1926 CNV Insertion 18451855
dgv2980n71 CNV Loss 21882294
nsv907283 CNV Loss 21882294
dgv2981n71 CNV Loss 21882294
nsv907288 CNV Loss 21882294
nsv471113 CNV Loss 18288195

Relevant External Links for CYBA Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)
Locus Specific Mutation Databases (LSDB)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CYBA Gene

Disorders for CYBA Gene

(1) OMIM Diseases for CYBA Gene (608508)


  • Granulomatous disease, chronic, cytochrome-b-negative, autosomal recessive (ARCGD) [MIM:233690]: A disorder characterized by the inability of neutrophils and phagocytes to kill microbes that they have ingested. Patients suffer from life-threatening bacterial/fungal infections. {ECO:0000269 PubMed:10759707, ECO:0000269 PubMed:10910929, ECO:0000269 PubMed:10914676, ECO:0000269 PubMed:1415254, ECO:0000269 PubMed:1763037, ECO:0000269 PubMed:18422995, ECO:0000269 PubMed:2243141, ECO:0000269 PubMed:23910690, ECO:0000269 PubMed:8168815}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(3) University of Copenhagen DISEASES for CYBA Gene

(17) Novoseek inferred disease relationships for CYBA Gene

Disease -log(P) Hits PubMed IDs
granulomatous disease chronic 87.8 17
atherosclerosis 49.7 9
coronary artery disease 47.7 9
cardiovascular diseases 40.1 2
coronary heart disease 30.5 7

Genatlas disease for CYBA Gene

chronic granulomatous disease,autosomal (cypb558 deficiency)

Relevant External Links for CYBA

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with CYBA: view

Publications for CYBA Gene

  1. Three common polymorphisms in the CYBA gene form a haplotype associated with decreased ROS generation. (PMID: 19388116) Bedard K. … Krause K.-H. (Hum. Mutat. 2009) 3 4 23 48
  2. Association of p22phox gene C242T polymorphism with coronary artery disease: a meta-analysis. (PMID: 20100625) Fang S. … Jia C. (Thromb. Res. 2010) 3 23 48
  3. Human neutrophil cytochrome b light chain (p22-phox). Gene structure, chromosomal location, and mutations in cytochrome-negative autosomal recessive chronic granulomatous disease. (PMID: 2243141) Dinauer M.C. … Orkin S.H. (J. Clin. Invest. 1990) 2 3 4
  4. No association between a genetic variant of the p22PHOX component of NADPH oxidase C242T and ulcerative colitis. (PMID: 19102345) Tahara T. … Hirata I. (Hepatogastroenterology 2008) 3 23 48
  5. Exercise training, NADPH oxidase p22phox gene polymorphisms, and hypertension. (PMID: 19516159) Feairheller D.L. … Fenty-Stewart N.M. (Med Sci Sports Exerc 2009) 3 23 48

Products for CYBA Gene

Sources for CYBA Gene

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